{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:57:15Z","timestamp":1780405035217,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Yunnan Provincial Clinical Research Center for Cardiovascular Diseases - Research Platform and Key Technologies for Diagnosis and Treatment of Cardiovascular Diseases","award":["202102AA310003"],"award-info":[{"award-number":["202102AA310003"]}]},{"name":"Yunnan Provincial Science and Technology Department-Key Project of Joint Special Fund for Applied Basic Research of Kunming Medical University","award":["2017FE468 (-008)"],"award-info":[{"award-number":["2017FE468 (-008)"]}]},{"name":"Yunnan Provincial Key Science and Technology Special Project","award":["2017ZF027"],"award-info":[{"award-number":["2017ZF027"]}]},{"name":"Kunming Health Science and Technology Talent Training Program","award":["2022-SW (Reserve)-38"],"award-info":[{"award-number":["2022-SW (Reserve)-38"]}]},{"name":"Yunnan Provincial Academician Expert Workstation Project","award":["202205AF150033"],"award-info":[{"award-number":["202205AF150033"]}]},{"name":"Yunnan Provincial Key Laboratory of Cardiovascular Diseases","award":["2018DG008"],"award-info":[{"award-number":["2018DG008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12033-025-01499-1","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T08:19:57Z","timestamp":1756973997000},"page":"2352-2368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exosomal LncRNA MALAT1 Derived from Hepatocytes in Nonalcoholic Fatty Liver Disease Regulates the miR-579-3p\/Keap1\/Nrf2 Pathway to Exacerbate Obstructive Sleep Apnea Syndrome"],"prefix":"10.1007","volume":"68","author":[{"given":"Lulu","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-6703","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"issue":"1","key":"1499_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41392-023-01496-3","volume":"8","author":"R Lv","year":"2023","unstructured":"Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023). Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome. Signal Transduction and Targeted Therapy, 8(1), 218.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"1499_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12974-020-01905-2","volume":"17","author":"X Liu","year":"2020","unstructured":"Liu, X., Ma, Y., Ouyang, R., Zeng, Z., Zhan, Z., Lu, H., Cui, Y., Dai, Z., Luo, L., He, C., Li, H., Zong, D., & Chen, Y. (2020). The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome. Journal of Neuroinflammation, 17(1), 229.","journal-title":"Journal of Neuroinflammation"},{"key":"1499_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2025.105997","volume":"188","author":"Y Huang","year":"2025","unstructured":"Huang, Y., Xie, H., Liu, L., Zhao, H., Li, B., & Zhang, F. (2025). Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2\/KEAP1\/HO-1 signaling. Neurochemistry International, 188, Article 105997.","journal-title":"Neurochemistry International"},{"issue":"2","key":"1499_CR4","doi-asserted-by":"publisher","first-page":"586","DOI":"10.14336\/AD.2020.0723","volume":"12","author":"L Yayong","year":"2021","unstructured":"Yayong, L., & Yina, W. (2021). Obstructive sleep apnea-hypopnea syndrome as a novel potential risk for aging. Aging Disease, 12(2), 586.","journal-title":"Aging Disease"},{"issue":"4","key":"1499_CR5","first-page":"425","volume":"14","author":"L Salvatore","year":"2024","unstructured":"Salvatore, L., Edoardo, M., Giannicola, I., Giuseppe, M., Annalisa, P., Jerome Rene, L., Christian, C.-H., Salvatore, C., Federica Maria, P., Valentin, F., Ahmed Yassin, B., Giovanni, C., Luigi, L. V., Caterina, G., Alberto, C., Claudio, V., & Antonino, M. (2024). Unraveling the complexities of oxidative stress and inflammation biomarkers in obstructive sleep apnea syndrome: A comprehensive review. Life (Basel), 14(4), 425.","journal-title":"Life (Basel)"},{"issue":"8","key":"1499_CR6","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1097\/MEG.0000000000001920","volume":"33","author":"GK Krolow","year":"2021","unstructured":"Krolow, G. K., Garcia, E., Schoor, F., Araujo, F. B. S., & Coral, G. P. (2021). Obstructive sleep apnea and severity of nonalcoholic fatty liver disease. European Journal of Gastroenterology & Hepatology, 33(8), 1104\u20131109.","journal-title":"European Journal of Gastroenterology & Hepatology"},{"issue":"1","key":"1499_CR7","doi-asserted-by":"publisher","first-page":"13473","DOI":"10.1038\/s41598-021-92703-0","volume":"11","author":"GE Chung","year":"2021","unstructured":"Chung, G. E., Cho, E. J., Yoo, J. J., Chang, Y., Cho, Y., Park, S. H., Shin, D. W., Han, K., & Yu, S. J. (2021). Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea. Scientific Reports, 11(1), 13473.","journal-title":"Scientific Reports"},{"issue":"43","key":"1499_CR8","doi-asserted-by":"publisher","first-page":"6099","DOI":"10.3748\/wjg.v28.i43.6099","volume":"28","author":"W Sheng","year":"2022","unstructured":"Sheng, W., Ji, G., & Zhang, L. (2022). Management of non-alcoholic fatty liver disease patients with sleep apnea syndrome. World Journal of Gastroenterology, 28(43), 6099\u20136108.","journal-title":"World Journal of Gastroenterology"},{"issue":"1","key":"1499_CR9","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s42003-024-06171-z","volume":"7","author":"L Yang","year":"2024","unstructured":"Yang, L., He, Y., Liu, S., Gan, L., Ni, Q., Dai, A., Mu, C., Liu, Q., Chen, H., Lu, H., & Sun, R. (2024). Adipocyte-derived exosomes from obstructive sleep apnoea rats aggravate MASLD by TCONS_00039830\/miR-455-3p\/Smad2 axis. Communications Biology, 7(1), 492.","journal-title":"Communications Biology"},{"key":"1499_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122028","author":"X Yu","year":"2016","unstructured":"Yu, X., Odenthal, M., & Fries, J. W. (2016). Exosomes as miRNA carriers: Formation-function-future. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms17122028","journal-title":"International Journal of Molecular Sciences"},{"issue":"39","key":"1499_CR11","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.2174\/0929867330666230123144602","volume":"30","author":"X Qiu","year":"2023","unstructured":"Qiu, X., & Chen, J. (2023). LSINCT5: A novel lncRNA in cancers. Current Medicinal Chemistry, 30(39), 4409\u20134420.","journal-title":"Current Medicinal Chemistry"},{"issue":"1","key":"1499_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12094-022-02876-x","volume":"25","author":"M Farzaneh","year":"2023","unstructured":"Farzaneh, M., Najafi, S., Anbiyaee, O., Azizidoost, S., & Khoshnam, S. E. (2023). LncRNA MALAT1-related signaling pathways in osteosarcoma. Clinical and Translational Oncology, 25(1), 21\u201332.","journal-title":"Clinical and Translational Oncology"},{"issue":"6","key":"1499_CR13","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/hep4.1184","volume":"2","author":"S Sookoian","year":"2018","unstructured":"Sookoian, S., Flichman, D., Garaycoechea, M. E., San Martino, J., Casta\u00f1o, G. O., & Pirola, C. J. (2018). Metastasis-associated lung adenocarcinoma transcript 1 as a common molecular driver in the pathogenesis of nonalcoholic steatohepatitis and chronic immune-mediated liver damage. Hepatology Communications, 2(6), 654\u2013665.","journal-title":"Hepatology Communications"},{"key":"1499_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.858558","volume":"10","author":"J Xiang","year":"2022","unstructured":"Xiang, J., Deng, Y. Y., Liu, H. X., & Pu, Y. (2022). LncRNA MALAT1 promotes PPAR\u03b1\/CD36-mediated hepatic lipogenesis in nonalcoholic fatty liver disease by modulating miR-206\/ARNT axis. Frontiers in Bioengineering and Biotechnology, 10, Article 858558.","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"1499_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101477","volume":"34","author":"C Mou","year":"2023","unstructured":"Mou, C., Li, Z., Liu, N., Ni, L., & Xu, Y. (2023). Low level TGF-\u03b21-treated umbilical mesenchymal stem cells attenuates microgliosis and neuropathic pain in chronic constriction injury by exosomes\/lncRNA UCA1\/miR-96-5p\/FOXO3a. Biochemistry and Biophysics Reports, 34, Article 101477.","journal-title":"Biochemistry and Biophysics Reports"},{"key":"1499_CR16","doi-asserted-by":"publisher","first-page":"9626831","DOI":"10.1155\/2016\/9626831","volume":"2016","author":"L Zhou","year":"2016","unstructured":"Zhou, L., Chen, P., Peng, Y., & Ouyang, R. (2016). Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome. Oxidative Medicine and Cellular Longevity, 2016, 9626831.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"1499_CR17","doi-asserted-by":"publisher","first-page":"1675957","DOI":"10.1155\/2020\/1675957","volume":"2020","author":"EHM Hassanein","year":"2020","unstructured":"Hassanein, E. H. M., Sayed, A. M., Hussein, O. E., & Mahmoud, A. M. (2020). Coumarins as modulators of the Keap1\/Nrf2\/ARE signaling pathway. Oxidative Medicine and Cellular Longevity, 2020, 1675957.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"Pt B","key":"1499_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113222","volume":"142","author":"R Lv","year":"2024","unstructured":"Lv, R., Zhao, Y., Wang, X., He, Y., Dong, N., Min, X., Liu, X., Yu, Q., Yuan, K., Yue, H., & Yin, Q. (2024). GLP-1 analogue liraglutide attenuates CIH-induced cognitive deficits by inhibiting oxidative stress, neuroinflammation, and apoptosis by the Nrf2\/HO-1 and MAPK\/NF-\u03baB signaling pathways. International Immunopharmacology, 142(Pt B), Article 113222.","journal-title":"International Immunopharmacology"},{"key":"1499_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116677","volume":"315","author":"J Si","year":"2023","unstructured":"Si, J., Liu, B., Qi, K., Chen, X., Li, D., Yang, S., & Ji, E. (2023). Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway. Journal of Ethnopharmacology, 315, Article 116677.","journal-title":"Journal of Ethnopharmacology"},{"key":"1499_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.115966","volume":"271","author":"H Li","year":"2024","unstructured":"Li, H., Liu, Y., Wang, X., Xu, C., Zhang, X., Zhang, J., Lin, L., & Niu, Q. (2024). MiR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1\/Nrf2 pathway. Ecotoxicology and Environmental Safety, 271, Article 115966.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"1499_CR21","doi-asserted-by":"publisher","first-page":"4825949","DOI":"10.1155\/2019\/4825949","volume":"2019","author":"Q Chu","year":"2019","unstructured":"Chu, Q., Zhang, S., Chen, M., Han, W., Jia, R., Chen, W., & Zheng, X. (2019). Cherry anthocyanins regulate NAFLD by promoting autophagy pathway. Oxidative Medicine and Cellular Longevity, 2019, 4825949.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"1499_CR22","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.2147\/NSS.S489232","volume":"16","author":"K Zhang","year":"2024","unstructured":"Zhang, K., Ma, D., Wu, Y., & Xu, Z. (2024). Impact of chronic intermittent hypoxia on cognitive function and hippocampal neurons in mice: A study of inflammatory and oxidative stress pathways. Nature and Science of Sleep, 16, 2029\u20132043.","journal-title":"Nature and Science of Sleep"},{"issue":"2","key":"1499_CR23","doi-asserted-by":"publisher","first-page":"704","DOI":"10.7150\/thno.80184","volume":"13","author":"K Xu","year":"2023","unstructured":"Xu, K., Ma, J., Hall, S. R. R., Peng, R. W., Yang, H., & Yao, F. (2023). Battles against aberrant KEAP1-NRF2 signaling in lung cancer: Intertwined metabolic and immune networks. Theranostics, 13(2), 704\u2013723.","journal-title":"Theranostics"},{"key":"1499_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna4030018","author":"A Hanson","year":"2018","unstructured":"Hanson, A., Wilhelmsen, D., & DiStefano, J. K. (2018). The role of long non-coding RNAs (lncRNAs) in the development and progression of fibrosis associated with nonalcoholic fatty liver disease (NAFLD). Non-Coding Rna. https:\/\/doi.org\/10.3390\/ncrna4030018","journal-title":"Non-Coding Rna"},{"issue":"2","key":"1499_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117990","volume":"10","author":"CS Lam","year":"2015","unstructured":"Lam, C. S., Tipoe, G. L., So, K. F., & Fung, M. L. (2015). Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PLoS One, 10(2), Article e0117990.","journal-title":"PLoS One"},{"issue":"17","key":"1499_CR26","doi-asserted-by":"publisher","first-page":"936","DOI":"10.21037\/atm-22-3818","volume":"10","author":"X Chen","year":"2022","unstructured":"Chen, X., Liu, H., Huang, R., Wei, R., Zhao, Y., & Li, T. (2022). Screening of plasma exosomal lncRNAs to identify potential biomarkers for obstructive sleep apnea. Annals of Translational Medicine, 10(17), 936.","journal-title":"Annals of Translational Medicine"},{"key":"1499_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061419","author":"CS Huang","year":"2020","unstructured":"Huang, C. S., Ho, J. Y., Chiang, J. H., Yu, C. P., & Yu, D. S. (2020). Exosome-derived LINC00960 and LINC02470 promote the epithelial-mesenchymal transition and aggressiveness of bladder cancer cells. Cells. https:\/\/doi.org\/10.3390\/cells9061419","journal-title":"Cells"},{"issue":"4","key":"1499_CR28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/cbic.201800470","volume":"20","author":"H Bu","year":"2019","unstructured":"Bu, H., He, D., He, X., & Wang, K. (2019). Exosomes: Isolation, analysis, and applications in cancer detection and therapy. ChemBioChem, 20(4), 451\u2013461.","journal-title":"ChemBioChem"},{"issue":"4","key":"1499_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.5664\/jcsm.10412","volume":"19","author":"M Li","year":"2023","unstructured":"Li, M., Sun, C., Xue, S., Leng, B., Sun, H., Shen, T., Liu, X., Li, Z., Shang, X., & Zhang, J. (2023). Complement protein levels in serum astrocyte-derived exosomes are associated with cognitive impairment in obstructive sleep apnea. Journal of Clinical Sleep Medicine, 19(4), 727\u2013739.","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"1499_CR30","doi-asserted-by":"publisher","DOI":"10.2174\/0113862073355701250512034857","author":"Z Wu","year":"2025","unstructured":"Wu, Z., Lai, X., Zhao, Y., Hong, J., Liu, Y., Liang, H., Wei, R., Chen, X., & Liu, W. (2025). Exosomal lncRNA ENST00000592016 rescues the weakened viability of HUVEC Cells caused by intermittent hypoxia. Combinatorial Chemistry & High Throughput Screening. https:\/\/doi.org\/10.2174\/0113862073355701250512034857","journal-title":"Combinatorial Chemistry & High Throughput Screening"},{"issue":"5","key":"1499_CR31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.14715\/cmb\/2021.67.5.45","volume":"67","author":"L Li","year":"2022","unstructured":"Li, L., Wang, Q., Xin, W., Wen, K., & Hang, Y. Z. (2022). The affection of plasma exosomes on airway obstruction and endothelial function in OSA patients. Cellular and Molecular Biology (Noisy-Le-Grand), 67(5), 332\u2013339.","journal-title":"Cellular and Molecular Biology (Noisy-Le-Grand)"},{"issue":"1","key":"1499_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s12967-024-05283-8","volume":"22","author":"L Yang","year":"2024","unstructured":"Yang, L., Liu, S., He, Y., Gan, L., Ni, Q., Dai, A., Mu, C., Liu, Q., Chen, H., Lu, H., & Sun, R. (2024). Exosomes regulate SIRT3-related autophagy by delivering miR-421 to regulate macrophage polarization and participate in OSA-related NAFLD. Journal of Translational Medicine, 22(1), 475.","journal-title":"Journal of Translational Medicine"},{"key":"1499_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112615","author":"PK Puvvula","year":"2019","unstructured":"Puvvula, P. K. (2019). LncRNAs regulatory networks in cellular senescence. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms20112615","journal-title":"International Journal of Molecular Sciences"},{"issue":"39","key":"1499_CR34","doi-asserted-by":"publisher","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","volume":"22","author":"P Ji","year":"2003","unstructured":"Ji, P., Diederichs, S., Wang, W., B\u00f6ing, S., Metzger, R., Schneider, P. M., Tidow, N., Brandt, B., Buerger, H., Bulk, E., Thomas, M., Berdel, W. E., Serve, H., & M\u00fcller-Tidow, C. (2003). MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene, 22(39), 8031\u201341.","journal-title":"Oncogene"},{"issue":"10","key":"1499_CR35","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1007\/s00018-019-03053-0","volume":"76","author":"S Mishra","year":"2019","unstructured":"Mishra, S., Verma, S. S., Rai, V., Awasthee, N., Chava, S., Hui, K. M., Kumar, A. P., Challagundla, K. B., Sethi, G., & Gupta, S. C. (2019). Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. Cellular and Molecular Life Sciences, 76(10), 1947\u20131966.","journal-title":"Cellular and Molecular Life Sciences"},{"key":"1499_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198405","volume":"298","author":"JZ Li","year":"2021","unstructured":"Li, J. Z., Ye, L. H., Wang, D. H., Zhang, H. C., Li, T. Y., Liu, Z. Q., Dai, E. H., & Li, M. R. (2021). The identify role and molecular mechanism of the MALAT1\/hsa-mir-20b-5p\/TXNIP axis in liver inflammation caused by CHB in patients with chronic HBV infection complicated with NAFLD. Virus Research, 298, Article 198405.","journal-title":"Virus Research"},{"key":"1499_CR37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fncel.2020.00097","volume":"14","author":"P Du","year":"2020","unstructured":"Du, P., Wang, J., Han, Y., & Feng, J. (2020). Blocking the lncRNA MALAT1\/miR-224-5p\/NLRP3 axis inhibits the hippocampal inflammatory response in T2DM with OSA. Frontiers in Cellular Neuroscience, 14, 97.","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"3","key":"1499_CR38","doi-asserted-by":"publisher","first-page":"637","DOI":"10.14336\/AD.2018.0513","volume":"10","author":"W Tu","year":"2019","unstructured":"Tu, W., Wang, H., Li, S., Liu, Q., & Sha, H. (2019). The anti-inflammatory and anti-oxidant mechanisms of the Keap1\/Nrf2\/ARE signaling pathway in chronic diseases. Aging and Disease, 10(3), 637\u2013651.","journal-title":"Aging and Disease"},{"issue":"9","key":"1499_CR39","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1007\/s11064-023-03942-8","volume":"48","author":"Y Huang","year":"2023","unstructured":"Huang, Y., Liu, Z., Wang, X., Li, Y., Liu, L., & Li, B. (2023). TGF-\u03b23 protects neurons against intermittent hypoxia-induced oxidative stress and apoptosis through activation of the Nrf-2\/KEAP1\/HO-1 pathway via binding to TGF-\u03b2RI. Neurochemical Research, 48(9), 2808\u20132825.","journal-title":"Neurochemical Research"},{"key":"1499_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.mito.2021.04.012","volume":"59","author":"Y Lu","year":"2021","unstructured":"Lu, Y., Bian, J., Kan, H., Ding, W., Wang, D., Wang, X., Luo, Q., Wu, X., & Zhu, L. (2021). Intermittent hypoxia preconditioning protects WRL68 cells against oxidative injury: Involvement of the PINK1\/Parkin-mediated mitophagy regulated by nuclear respiratory factor 1. Mitochondrion, 59, 113\u2013122.","journal-title":"Mitochondrion"},{"issue":"1","key":"1499_CR41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2337\/db20-0375","volume":"70","author":"R Radhakrishnan","year":"2021","unstructured":"Radhakrishnan, R., & Kowluru, R. A. (2021). Long noncoding RNA MALAT1 and regulation of the antioxidant defense system in diabetic retinopathy. Diabetes, 70(1), 227\u2013239.","journal-title":"Diabetes"},{"key":"1499_CR42","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.redox.2018.07.002","volume":"18","author":"XJ Zhao","year":"2018","unstructured":"Zhao, X. J., Yu, H. W., Yang, Y. Z., Wu, W. Y., Chen, T. Y., Jia, K. K., Kang, L. L., Jiao, R. Q., & Kong, L. D. (2018). Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1\/Nrf2 pathway. Redox Biology, 18, 124\u2013137.","journal-title":"Redox Biology"},{"issue":"21","key":"1499_CR43","first-page":"9464","volume":"23","author":"R-R W","year":"2019","unstructured":"W, R.-R., Z, Q., L, H.-F., & L, S.-B. (2019). Role of miR-579-3p in the development of squamous cell lung carcinoma and the regulatory mechanisms. European Review Medical Pharmacological Sciences, 23(21), 9464\u20139470.","journal-title":"European Review Medical Pharmacological Sciences"},{"key":"1499_CR44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607753113","author":"F Luigi","year":"2016","unstructured":"Luigi, F., Rita, M., Mario, A., Giulia, R., Alessandro, L., Maria Elena, P., Debora, M., Gabriele, M., Domenico, M., Marilena, C., Franco, F., Luca, M., Gerardo, B., Carlo, M., & Paolo AntonioGennaro, C. A. C. (2016). miR-579-3p controls melanoma progression and resistance to target therapy. Proceedings of the National Academy Sciences. https:\/\/doi.org\/10.1073\/pnas.1607753113","journal-title":"Proceedings of the National Academy Sciences"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01499-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-025-01499-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01499-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:45:24Z","timestamp":1779795924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-025-01499-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1499"],"URL":"https:\/\/doi.org\/10.1007\/s12033-025-01499-1","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"assertion":[{"value":"10 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental rat protocols were approved by the Animal Ethics Committee. All methods were performed in accordance with the relevant guidelines and regulations and in accordance with ARRIVE\u00a0guidelines. All participants were provided with information regarding the study and gave their written informed consent prior to participation. This study was conducted in compliance with the Declaration of Helsinki and all applicable ethical guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}