{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:08:36Z","timestamp":1787501316044,"version":"build-2736575974"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Project of Ningbo Key R&D Plan and \u201cUnveiling and Leading\u201d","award":["2023Z174"],"award-info":[{"award-number":["2023Z174"]}]},{"name":"Ningbo Clinical Research Center for Emergency and Critical Diseases","award":["2024L003"],"award-info":[{"award-number":["2024L003"]}]},{"name":"Zhejiang medicine and health science and technology project","award":["2025KY238"],"award-info":[{"award-number":["2025KY238"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biotechnol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12033-025-01521-6","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:51:43Z","timestamp":1761850303000},"page":"2560-2574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SMURF2-Mediated Ubiquitination and Degradation of HOXA5 Augments Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells Induced by LPS"],"prefix":"10.1007","volume":"68","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7714-834X","authenticated-orcid":false,"given":"Weijian","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"issue":"7","key":"1521_CR1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1161\/CIRCRESAHA.124.325855","volume":"136","author":"H Hong","year":"2025","unstructured":"Hong, H., Wu, Y., Li, Y., Han, Y., Cao, X., Wu, V. W. Y., et al. (2025). Endothelial PPARdelta ablation exacerbates vascular hyperpermeability via STAT1\/CXCL10 signaling in acute lung injury. Circulation Research, 136(7), 735\u2013751.","journal-title":"Circulation Research"},{"issue":"1","key":"1521_CR2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2024-1076","volume":"19","author":"K Zhou","year":"2024","unstructured":"Zhou, K., & Lu, J. (2024). Progress in cytokine research for ARDS: A comprehensive review. Open Medicine, 19(1), Article 20241076.","journal-title":"Open Medicine"},{"key":"1521_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116773","volume":"175","author":"J Zheng","year":"2024","unstructured":"Zheng, J., Li, Y., Kong, X., & Guo, J. (2024). Exploring immune-related pathogenesis in lung injury: Providing new insights into ALI\/ARDS. Biomedicine & Pharmacotherapy, 175, Article 116773.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"1521_CR4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","volume":"19","author":"J Li","year":"2021","unstructured":"Li, J., Lu, K., Sun, F., Tan, S., Zhang, X., Sheng, W., et al. (2021). Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway. Journal Of Translational Medicine, 19(1), 96.","journal-title":"Journal Of Translational Medicine"},{"issue":"12","key":"1521_CR5","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1074\/mcp.RA117.000072","volume":"16","author":"P Seddigh","year":"2017","unstructured":"Seddigh, P., Bracht, T., Molinier-Frenkel, V., Castellano, F., Kniemeyer, O., Schuster, M., et al. (2017). Quantitative Analysis of proteome modulations in alveolar epithelial type II cells in response to pulmonary aspergillus fumigatus infection. Molecular and Cellular Proteomics, 16(12), 2184\u20132198.","journal-title":"Molecular and Cellular Proteomics"},{"issue":"2","key":"1521_CR6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1124\/jpet.121.000712","volume":"379","author":"Q Yang","year":"2021","unstructured":"Yang, Q., Xu, H. R., Xiang, S. Y., Zhang, C., Ye, Y., Shen, C. X., et al. (2021). Resolvin conjugates in tissue regeneration 1 promote alveolar fluid clearance by activating alveolar epithelial sodium channels and Na, K-ATPase in lipopolysaccharide-induced acute lung injury. Journal of Pharmacology and Experimental Therapeutics, 379(2), 156\u2013165.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"1521_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen, X., Shi, C., He, M., Xiong, S., & Xia, X. (2023). Endoplasmic reticulum stress: Molecular mechanism and therapeutic targets. Signal Transduction and Targeted Therapy, 8(1), 352.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"2","key":"1521_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41573-021-00320-3","volume":"21","author":"SJ Marciniak","year":"2022","unstructured":"Marciniak, S. J., Chambers, J. E., & Ron, D. (2022). Pharmacological targeting of endoplasmic reticulum stress in disease. Nature Reviews Drug Discovery, 21(2), 115\u2013140.","journal-title":"Nature Reviews Drug Discovery"},{"issue":"20","key":"1521_CR9","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1182\/blood-2014-11-611046","volume":"125","author":"MS Njock","year":"2015","unstructured":"Njock, M. S., Cheng, H. S., Dang, L. T., Nazari-Jahantigh, M., Lau, A. C., Boudreau, E., et al. (2015). Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood, 125(20), 3202\u20133212.","journal-title":"Blood"},{"key":"1521_CR10","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/fmed.2020.00344","volume":"7","author":"N Barabutis","year":"2020","unstructured":"Barabutis, N. (2020). Unfolded protein response in lung health and disease. Front Med (Lausanne)., 7, 344.","journal-title":"Front Med (Lausanne)."},{"key":"1521_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113800","volume":"155","author":"F Fan","year":"2022","unstructured":"Fan, F., Mo, H., Zhang, H., Dai, Z., Wang, Z., Qu, C., et al. (2022). HOXA5: A crucial transcriptional factor in cancer and a potential therapeutic target. Biomedicine & Pharmacotherapy, 155, Article 113800.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"10","key":"1521_CR12","doi-asserted-by":"publisher","first-page":"7029","DOI":"10.1111\/jcmm.14600","volume":"23","author":"W Cao","year":"2019","unstructured":"Cao, W., Zhang, T., Feng, R., Xia, T., Huang, H., Liu, C., et al. (2019). Hoxa5 alleviates obesity-induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue. Journal of Cellular and Molecular Medicine, 23(10), 7029\u20137042.","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"2","key":"1521_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.4049\/jimmunol.1601826","volume":"199","author":"C Ptaschinski","year":"2017","unstructured":"Ptaschinski, C., Hrycaj, S. M., Schaller, M. A., Wellik, D. M., & Lukacs, N. W. (2017). Hox5 paralogous genes modulate Th2 cell function during chronic allergic inflammation via regulation of Gata3. Journal of Immunology (Baltimore, Md.\u202f: 1950), 199(2), 501\u2013509.","journal-title":"Journal of Immunology (Baltimore, Md. : 1950)"},{"key":"1521_CR14","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3389\/fimmu.2018.00647","volume":"9","author":"W Cao","year":"2018","unstructured":"Cao, W., Huang, H., Xia, T., Liu, C., Muhammad, S., & Sun, C. (2018). Homeobox a5 promotes white adipose tissue browning through inhibition of the Tenascin C\/Toll-like receptor 4\/Nuclear factor kappa B inflammatory signaling in mice. Frontiers in Immunology, 9, 647.","journal-title":"Frontiers in Immunology"},{"issue":"19","key":"1521_CR15","doi-asserted-by":"publisher","first-page":"9431","DOI":"10.7150\/thno.61902","volume":"11","author":"Y Ni","year":"2021","unstructured":"Ni, Y., Hu, B. C., Wu, G. H., Shao, Z. Q., Zheng, Y., Zhang, R., et al. (2021). Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI. Theranostics, 11(19), 9431\u20139451.","journal-title":"Theranostics"},{"key":"1521_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fmolb.2020.00128","volume":"7","author":"Y Bai","year":"2020","unstructured":"Bai, Y., & Ying, Y. (2020). The post-translational modifications of Smurf2 in TGF-beta signaling. Frontiers in Molecular Biosciences, 7, 128.","journal-title":"Frontiers in Molecular Biosciences"},{"issue":"4","key":"1521_CR17","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.bbrc.2008.07.103","volume":"374","author":"I Carpentier","year":"2008","unstructured":"Carpentier, I., Coornaert, B., & Beyaert, R. (2008). Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation. Biochemical and Biophysical Research Communications, 374(4), 752\u2013757.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"6","key":"1521_CR18","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.4049\/jimmunol.1402647","volume":"194","author":"JA Zepp","year":"2015","unstructured":"Zepp, J. A., Wu, L., Qian, W., Ouyang, W., Aronica, M., Erzurum, S., et al. (2015). TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation. Journal of Immunology (Baltimore, Md.\u202f: 1950), 194(6), 2826\u20132837.","journal-title":"Journal of Immunology (Baltimore, Md. : 1950)"},{"issue":"5","key":"1521_CR19","doi-asserted-by":"publisher","first-page":"C632","DOI":"10.1152\/ajpcell.00443.2018","volume":"316","author":"S Dong","year":"2019","unstructured":"Dong, S., Liu, J., Li, L., Wang, H., Ma, H., Zhao, Y., et al. (2019). The HECT ubiquitin E3 ligase Smurf2 degrades mu-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells. American Journal of Physiology. Cell Physiology, 316(5), C632\u2013C640.","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"3","key":"1521_CR20","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1159\/000487343","volume":"45","author":"W Cao","year":"2018","unstructured":"Cao, W., Xu, Y., Luo, D., Saeed, M., & Sun, C. (2018). Hoxa5 promotes adipose differentiation via increasing DNA methylation level and inhibiting PKA\/HSL signal pathway in mice. Cell Physiology and Biochemistry, 45(3), 1023\u20131033.","journal-title":"Cell Physiology and Biochemistry"},{"issue":"4","key":"1521_CR21","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.bbrc.2018.01.150","volume":"496","author":"Y Gong","year":"2018","unstructured":"Gong, Y., Yu, Z., Gao, Y., Deng, L., Wang, M., Chen, Y., et al. (2018). FABP4 inhibitors suppress inflammation and oxidative stress in murine and cell models of acute lung injury. Biochemical and Biophysical Research Communications, 496(4), 1115\u20131121.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"1521_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4103\/EJPI.EJPI-D-23-00027","volume":"67","author":"S Xu","year":"2024","unstructured":"Xu, S., Luo, J., Wang, Y., & Chen, X. (2024). Fatty acid binding protein-4 silencing inhibits ferroptosis to alleviate lipopolysaccharide-induced injury of renal tubular epithelial cells by blocking Janus kinase 2\/signal transducer and activator of transcription 3 signaling. Journal of Physiological Investigation, 67(1), 47\u201356.","journal-title":"Journal of Physiological Investigation"},{"issue":"4","key":"1521_CR23","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1007\/s11033-021-06379-w","volume":"48","author":"J Obradovic","year":"2021","unstructured":"Obradovic, J., Todosijevic, J., & Jurisic, V. (2021). Application of the conventional and novel methods in testing EGFR variants for NSCLC patients in the last 10 years through different regions: A systematic review. Molecular Biology Reports, 48(4), 3593\u20133604.","journal-title":"Molecular Biology Reports"},{"issue":"3","key":"1521_CR24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00232-010-9309-7","volume":"239","author":"V Jurisic","year":"2011","unstructured":"Jurisic, V., Srdic-Rajic, T., Konjevic, G., Bogdanovic, G., & Colic, M. (2011). TNF-alpha induced apoptosis is accompanied with rapid CD30 and slower CD45 shedding from K-562 cells. Journal of Membrane Biology, 239(3), 115\u2013122.","journal-title":"Journal of Membrane Biology"},{"key":"1521_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.103700","volume":"58","author":"D Arsenijevi\u0107","year":"2024","unstructured":"Arsenijevi\u0107, D., Jovanovi\u0107, M., Peci\u0107, K., Juri\u0161i\u0107, V., Virijevi\u0107, K., Miti\u0107, M., et al. (2024). Laetiporus sulphureus mushroom extract strongly enhances proapoptotic effect of probiotics Bifidobacterium lactis on HCT-116 cells in a co-culture system. Food Bioscience, 58, Article 103700.","journal-title":"Food Bioscience"},{"issue":"6","key":"1521_CR26","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.bbamcr.2016.11.026","volume":"1864","author":"BP Diercks","year":"2017","unstructured":"Diercks, B. P., Fliegert, R., & Guse, A. H. (2017). Mag-fluo4 in T cells: Imaging of intra-organelle free Ca(2+) concentrations. Biochimica Et Biophysica Acta, Molecular Cell Research, 1864(6), 977\u2013986.","journal-title":"Biochimica Et Biophysica Acta, Molecular Cell Research"},{"issue":"8","key":"1521_CR27","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s00210-023-02426-4","volume":"396","author":"MK Shahrestanaki","year":"2023","unstructured":"Shahrestanaki, M. K., Mirjani, A., Ghanadian, M., & Aghaei, M. (2023). Cycloartane triterpenoid from Euphorbia macrostegia modulates ER stress signaling pathways to induce apoptosis in MDA-MB231 and MCF-7 breast cancer cell lines. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology, 396(8), 1749\u20131758.","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"issue":"D1","key":"1521_CR28","doi-asserted-by":"publisher","first-page":"D719","DOI":"10.1093\/nar\/gkab962","volume":"50","author":"X Wang","year":"2022","unstructured":"Wang, X., Li, Y., He, M., Kong, X., Jiang, P., Liu, X., et al. (2022). Ubibrowser 2.0: A comprehensive resource for proteome-wide known and predicted ubiquitin ligase\/deubiquitinase-substrate interactions in eukaryotic species. Nucleic Acids Research, 50(D1), D719\u2013D728.","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"1521_CR29","doi-asserted-by":"publisher","first-page":"D174","DOI":"10.1093\/nar\/gkad1059","volume":"52","author":"I Rauluseviciute","year":"2024","unstructured":"Rauluseviciute, I., Riudavets-Puig, R., Blanc-Mathieu, R., Castro-Mondragon, J. A., Ferenc, K., Kumar, V., et al. (2024). JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Research, 52(D1), D174\u2013D182.","journal-title":"Nucleic Acids Research"},{"key":"1521_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2024.100196","volume":"7","author":"Y Hirata","year":"2024","unstructured":"Hirata, Y., Takemori, H., Furuta, K., Kamatari, Y. O., & Sawada, M. (2024). Ferroptosis induces nucleolar stress as revealed by live-cell imaging using thioflavin T. Current Research in Pharmacology and Drug Discovery, 7, Article 100196.","journal-title":"Current Research in Pharmacology and Drug Discovery"},{"issue":"11","key":"1521_CR31","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1002\/ajh.27054","volume":"98","author":"TM Kadia","year":"2023","unstructured":"Kadia, T. M., Ravandi, F., Molica, M., Bataller, A., Borthakur, G., Daver, N., et al. (2023). Phase II study of cladribine, idarubicin, and ara-C (CLIA) with or without sorafenib as initial therapy for patients with acute myeloid leukemia. American Journal of Hematology, 98(11), 1711\u20131720.","journal-title":"American Journal of Hematology"},{"issue":"4","key":"1521_CR32","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1111\/1750-3841.16985","volume":"89","author":"C Yang","year":"2024","unstructured":"Yang, C., Li, S., Li, C., Li, J., Shi, R., Cao, J., et al. (2024). Preparation of red jujube powder with high content of Amadori compounds and higher antioxidant activity by controlling the Maillard reaction. Journal of Food Science, 89(4), 2218\u20132231.","journal-title":"Journal of Food Science"},{"issue":"23","key":"1521_CR33","doi-asserted-by":"publisher","first-page":"5374","DOI":"10.12998\/wjcc.v12.i23.5374","volume":"12","author":"Y Liu","year":"2024","unstructured":"Liu, Y., & Chen, L. (2024). Impact of interleukin 6 levels on acute lung injury risk and disease severity in critically ill sepsis patients. World Journal of Clinical Cases, 12(23), 5374\u20135381.","journal-title":"World Journal of Clinical Cases"},{"key":"1521_CR34","unstructured":"Guido A, Santoro PE, DA DEC, Peruzzi L, Chieffo DP, Gualano MR, et al. Prevalence of burnout and psycho-emotional disorders among non-health workers: a single tertiary care pediatric oncology center experience. Minerva Pediatr (Torino). 2024."},{"issue":"7","key":"1521_CR35","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1601-0825.2007.01426.x","volume":"14","author":"V Jurisic","year":"2008","unstructured":"Jurisic, V., Terzic, T., Colic, S., & Jurisic, M. (2008). The concentration of TNF-alpha correlate with number of inflammatory cells and degree of vascularization in radicular cysts. Oral Diseases, 14(7), 600\u2013605.","journal-title":"Oral Diseases"},{"key":"1521_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156700","volume":"141","author":"Y Huang","year":"2025","unstructured":"Huang, Y., Li, G., Li, D., Liu, C., Chen, M., Cai, L., et al. (2025). Ethyl caffeate alleviates inflammatory response and promotes recovery in septic-acute lung injury via the TNF-alpha\/NF-kappaB\/MMP9 Axis. Phytomedicine, 141, Article 156700.","journal-title":"Phytomedicine"},{"issue":"9","key":"1521_CR37","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00011-020-01378-2","volume":"69","author":"X Chen","year":"2020","unstructured":"Chen, X., Tang, J., Shuai, W., Meng, J., Feng, J., & Han, Z. (2020). Macrophage polarization and its role in the pathogenesis of acute lung injury\/acute respiratory distress syndrome. Inflammation Research, 69(9), 883\u2013895.","journal-title":"Inflammation Research"},{"issue":"Suppl 3","key":"1521_CR38","first-page":"S353","volume":"69","author":"D Mokra","year":"2020","unstructured":"Mokra, D. (2020). Acute lung injury - from pathophysiology to treatment. Physiological Research, 69(Suppl 3), S353\u2013S366.","journal-title":"Physiological Research"},{"issue":"4","key":"1521_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1159\/000121471","volume":"40","author":"HM Wang","year":"2008","unstructured":"Wang, H. M., Bodenstein, M., & Markstaller, K. (2008). Overview of the pathology of three widely used animal models of acute lung injury. European Surgical Research, 40(4), 305\u2013316.","journal-title":"European Surgical Research"},{"key":"1521_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2022.116865","volume":"71","author":"L Jiang","year":"2022","unstructured":"Jiang, L., Xu, L., Zheng, L., Wang, Y., Zhuang, M., & Yang, D. (2022). Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. Bioorganic & Medicinal Chemistry, 71, Article 116865.","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"1521_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110398","volume":"97","author":"F Wang","year":"2022","unstructured":"Wang, F., Ma, J., Wang, J., Chen, M., Xia, H., Yao, S., et al. (2022). SIRT1 ameliorated septic associated-lung injury and macrophages apoptosis via inhibiting endoplasmic reticulum stress. Cellular Signalling, 97, Article 110398.","journal-title":"Cellular Signalling"},{"key":"1521_CR42","doi-asserted-by":"publisher","first-page":"1152336","DOI":"10.3389\/fimmu.2023.1152336","volume":"14","author":"S Liu","year":"2023","unstructured":"Liu, S., Fang, X., Zhu, R., Zhang, J., Wang, H., Lei, J., et al. (2023). Role of endoplasmic reticulum autophagy in acute lung injury. Frontiers in Immunology, 14, 1152336.","journal-title":"Frontiers in Immunology"},{"key":"1521_CR43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.toxlet.2017.02.023","volume":"271","author":"M Zeng","year":"2017","unstructured":"Zeng, M., Sang, W., Chen, S., Chen, R., Zhang, H., Xue, F., et al. (2017). 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models. Toxicology Letters, 271, 26\u201337.","journal-title":"Toxicology Letters"},{"key":"1521_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/cells12162090","author":"L Parrillo","year":"2023","unstructured":"Parrillo, L., Spinelli, R., Longo, M., Zatterale, F., Santamaria, G., Leone, A., et al. (2023). The transcription factor HOXA5: Novel insights into metabolic diseases and adipose tissue dysfunction. Cells. https:\/\/doi.org\/10.3390\/cells12162090","journal-title":"Cells"},{"issue":"2","key":"1521_CR45","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.bbrc.2011.05.139","volume":"410","author":"JY Lee","year":"2011","unstructured":"Lee, J. Y., Park, K. S., Cho, E. J., Joo, H. K., Lee, S. K., Lee, S. D., et al. (2011). Human HOXA5 homeodomain enhances protein transduction and its application to vascular inflammation. Biochemical and Biophysical Research Communications, 410(2), 312\u2013316.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"1521_CR46","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12915-024-02047-0","volume":"22","author":"Q Chen","year":"2024","unstructured":"Chen, Q., Ren, Z., Dang, L., Liu, Z., Wang, S., Chen, X., et al. (2024). Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC. BMC Biology, 22(1), 247.","journal-title":"BMC Biology"},{"key":"1521_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/jdb4020013","author":"L Jeannotte","year":"2016","unstructured":"Jeannotte, L., Gotti, F., & Landry-Truchon, K. (2016). Hoxa5: A key player in development and disease. Journal of Developmental Biology. https:\/\/doi.org\/10.3390\/jdb4020013","journal-title":"Journal of Developmental Biology"},{"issue":"5","key":"1521_CR48","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/stem.3332","volume":"39","author":"M Ma","year":"2021","unstructured":"Ma, M., Yang, W., Cai, Z., Wang, P., Li, H., Mi, R., et al. (2021). SMAD-specific E3 ubiquitin ligase 2 promotes angiogenesis by facilitating PTX3 degradation in MSCs from patients with ankylosing spondylitis. Stem Cells, 39(5), 581\u2013599.","journal-title":"Stem Cells"},{"issue":"1","key":"1521_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112002","volume":"42","author":"X Kong","year":"2023","unstructured":"Kong, X., Lu, X., Wang, S., Hao, J., Guo, D., Wu, H., et al. (2023). Type I interferon\/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner. Cell Reports, 42(1), Article 112002.","journal-title":"Cell Reports"},{"key":"1521_CR50","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.2147\/CMAR.S178111","volume":"11","author":"F Klupp","year":"2019","unstructured":"Klupp, F., Giese, C., Halama, N., Franz, C., Lasitschka, F., Warth, A., et al. (2019). E3 ubiquitin ligase Smurf2: A prognostic factor in microsatellite stable colorectal cancer. Cancer Manag Res., 11, 1795\u20131803.","journal-title":"Cancer Manag Res."},{"issue":"4","key":"1521_CR51","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1194\/jlr.S091793","volume":"60","author":"KJ Prentice","year":"2019","unstructured":"Prentice, K. J., Saksi, J., & Hotamisligil, G. S. (2019). Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. Journal of Lipid Research, 60(4), 734\u2013740.","journal-title":"Journal of Lipid Research"},{"issue":"1","key":"1521_CR52","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s00018-024-05474-y","volume":"81","author":"W Xuan","year":"2024","unstructured":"Xuan, W., Wu, X., Zheng, L., Jia, H., Zhang, X., Zhang, X., et al. (2024). Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4. Cellular and Molecular Life Sciences, 81(1), 438.","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"3","key":"1521_CR53","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3892\/etm.2021.9612","volume":"21","author":"XL Yang","year":"2021","unstructured":"Yang, X. L., Mi, J. H., & Dong, Q. (2021). FABP4 alleviates endoplasmic reticulum stress-mediated ischemia-reperfusion injury in PC12 cells via regulation of PPARgamma. Experimental and Therapeutic Medicine, 21(3), 181.","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"6","key":"1521_CR54","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1262\/jrd.2023-015","volume":"69","author":"M Song","year":"2023","unstructured":"Song, M., Hao, K., Qi, F., Zhao, W., Wang, Z., Wang, J., et al. (2023). FABP4 mediates endoplasmic reticulum stress and autophagy to regulate endometrial epithelial cell function during early sheep gestation. Journal of Reproduction and Development, 69(6), 298\u2013307.","journal-title":"Journal of Reproduction and Development"},{"issue":"19","key":"1521_CR55","doi-asserted-by":"publisher","first-page":"11188","DOI":"10.1111\/jcmm.15666","volume":"24","author":"F Sun","year":"2020","unstructured":"Sun, F., Du, J., Li, H., Hao, S., Zhao, G., & Lu, F. (2020). FABP4 inhibitor BMS309403 protects against hypoxia-induced H9c2 cardiomyocyte apoptosis through attenuating endoplasmic reticulum stress. Journal of Cellular and Molecular Medicine, 24(19), 11188\u201311197.","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"2","key":"1521_CR56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/14728222.2022.2035720","volume":"26","author":"AA Sunil","year":"2022","unstructured":"Sunil, A. A., & Skaria, T. (2022). Novel regulators of airway epithelial barrier function during inflammation: Potential targets for drug repurposing. Expert Opinion on Therapeutic Targets, 26(2), 119\u2013132.","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"1521_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/bios15060338","author":"G Caragnano","year":"2025","unstructured":"Caragnano, G., Monteduro, A. G., Rizzato, S., Giannelli, G., & Maruccio, G. (2025). Biological barrier models-on-chips: A novel tool for disease research and drug discovery. Biosensors. https:\/\/doi.org\/10.3390\/bios15060338","journal-title":"Biosensors"},{"key":"1521_CR58","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-94-017-7215-0_8","volume":"867","author":"V Jurisic","year":"2015","unstructured":"Jurisic, V., Radenkovic, S., & Konjevic, G. (2015). The actual role of LDH as tumor marker, biochemical and clinical aspects. Advances in Experimental Medicine and Biology, 867, 115\u2013124.","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"9","key":"1521_CR59","doi-asserted-by":"publisher","first-page":"541","DOI":"10.2298\/VSP240422050J","volume":"81","author":"V Jurisic","year":"2024","unstructured":"Jurisic, V., Todorovic-Balint, M., Jevtic, A., & Balint, B. (2024). The importance of determining lactate dehydrogenase in laboratory and experimental work in oncology. Vojnosanitetski Pregled, 81(9), 541\u2013546.","journal-title":"Vojnosanitetski Pregled"}],"container-title":["Molecular Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01521-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12033-025-01521-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12033-025-01521-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:02:28Z","timestamp":1779800548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12033-025-01521-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1521"],"URL":"https:\/\/doi.org\/10.1007\/s12033-025-01521-6","relation":{},"ISSN":["1073-6085","1559-0305"],"issn-type":[{"value":"1073-6085","type":"print"},{"value":"1559-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}