{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:35:06Z","timestamp":1759775706600,"version":"3.38.0"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:00:00Z","timestamp":1296172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s12035-011-8167-3","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T01:25:37Z","timestamp":1296091537000},"page":"192-206","source":"Crossref","is-referenced-by-count":16,"title":["Evolution of the VEGF-Regulated Vascular Network from a Neural Guidance System"],"prefix":"10.1007","volume":"43","author":[{"given":"Sreenivasan","family":"Ponnambalam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Alberghina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,28]]},"reference":[{"key":"8167_CR1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature03875","volume":"436","author":"P Carmeliet","year":"2005","unstructured":"Carmeliet P, Tessier-Lavigne M (2005) Common mechanisms of nerve and blood vessel wiring. Nature 436:193\u2013200","journal-title":"Nature"},{"key":"8167_CR2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.conb.2005.01.008","volume":"15","author":"A Eichmann","year":"2005","unstructured":"Eichmann A, Le Noble F, Autiero M, Carmeliet P (2005) Guidance of vascular and neural network formation. Curr Opin Neurobiol 15:108\u2013115","journal-title":"Curr Opin Neurobiol"},{"key":"8167_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(07)80001-9","volume":"80","author":"S Zacchigna","year":"2008","unstructured":"Zacchigna S, Ruiz de Almodovar C, Carmeliet P (2008) Similarities between angiogenesis and neural development: what small animal models can tell us. Curr Top Dev Biol 80:1\u201355","journal-title":"Curr Top Dev Biol"},{"key":"8167_CR4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1152\/physrev.00031.2008","volume":"89","author":"C Ruiz de Almodovar","year":"2009","unstructured":"Ruiz de Almodovar C, Lambrechts D, Mazzone M, Carmeliet P (2009) Role and therapeutic potential of VEGF in the nervous system. Physiol Rev 89:607\u2013648","journal-title":"Physiol Rev"},{"key":"8167_CR5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nrc2505","volume":"8","author":"SJ Harper","year":"2008","unstructured":"Harper SJ, Bates DO (2008) VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 8:880\u2013887","journal-title":"Nat Rev Cancer"},{"key":"8167_CR6","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1167\/iovs.09-4360","volume":"51","author":"J Hua","year":"2010","unstructured":"Hua J, Spee C, Kase S, Rennel ES, Magnussen AL, Qiu Y, Varey A, Dhayade S, Churchill AJ, Harper SJ, Bates DO, Hinton DR (2010) Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 51:4282\u20134288","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8167_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/dvdy.20139","volume":"231","author":"K Seipel","year":"2004","unstructured":"Seipel K, Eberhardt M, Muller P, Pescia E, Yanze N, Schmid V (2004) Homologs of vascular endothelial growth factor and receptor, VEGF and VEGFR, in the jellyfish Podocoryne carnea. Dev Dyn 231:303\u2013312","journal-title":"Dev Dyn"},{"key":"8167_CR8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1096\/fj.05-4147com","volume":"20","author":"M Tarsitano","year":"2006","unstructured":"Tarsitano M, De Falco S, Colonna V, McGhee JD, Persico MG (2006) The C. elegans pvf-1 gene encodes a PDGF\/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis. FASEB J 20:227\u2013233","journal-title":"FASEB J"},{"key":"8167_CR9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00502-5","volume":"107","author":"P Duchek","year":"2001","unstructured":"Duchek P, Somogyi K, Jekely G, Beccari S, Rorth P (2001) Guidance of cell migration by the Drosophila PDGF\/VEGF receptor. Cell 107:17\u201326","journal-title":"Cell"},{"key":"8167_CR10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0092-8674(02)00676-1","volume":"108","author":"NK Cho","year":"2002","unstructured":"Cho NK, Keyes L, Johnson E, Heller J, Ryner L, Karim F, Krasnow MA (2002) Developmental control of blood cell migration by the Drosophila VEGF pathway. Cell 108:865\u2013876","journal-title":"Cell"},{"key":"8167_CR11","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.1073\/pnas.94.14.7192","volume":"94","author":"YA Muller","year":"1997","unstructured":"Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, de Vos AM (1997) Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor-binding site. Proc Natl Acad Sci USA 94:7192\u20137197","journal-title":"Proc Natl Acad Sci USA"},{"key":"8167_CR12","doi-asserted-by":"crossref","first-page":"17114","DOI":"10.1074\/jbc.M301728200","volume":"278","author":"LJ Reigstad","year":"2003","unstructured":"Reigstad LJ, Sande HM, Fluge O, Bruland O, Muga A, Varhaug JE, Martinez A, Lillehaug JR (2003) Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. J Biol Chem 278:17114\u201317120","journal-title":"J Biol Chem"},{"key":"8167_CR13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","volume":"141","author":"MA Lemmon","year":"2010","unstructured":"Lemmon MA, Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141:1117\u20131134","journal-title":"Cell"},{"key":"8167_CR14","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1038\/sj.onc.1203957","volume":"19","author":"DR Robinson","year":"2000","unstructured":"Robinson DR, Wu YM, Lin SF (2000) The protein tyrosine kinase family of the human genome. Oncogene 19:5548\u20135557","journal-title":"Oncogene"},{"key":"8167_CR15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.yexcr.2005.11.012","volume":"312","author":"M Shibuya","year":"2006","unstructured":"Shibuya M, Claesson-Welsh L (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 312:549\u2013560","journal-title":"Exp Cell Res"},{"key":"8167_CR16","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.cub.2003.09.002","volume":"13","author":"RC Bates","year":"2003","unstructured":"Bates RC, Goldsmith JD, Bachelder RE, Brown C, Shibuya M, Oettgen P, Mercurio AM (2003) Flt-1-dependent survival characterizes the epithelial\u2013mesenchymal transition of colonic organoids. Curr Biol 13:1721\u20131727","journal-title":"Curr Biol"},{"key":"8167_CR17","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1167\/iovs.07-0354","volume":"48","author":"KM Nishiguchi","year":"2007","unstructured":"Nishiguchi KM, Nakamura M, Kaneko H, Kachi S, Terasaki H (2007) The role of VEGF and VEGFR2\/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration. Invest Ophthalmol Vis Sci 48:4315\u20134320","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8167_CR18","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1096\/fj.09-143180","volume":"24","author":"L Zentilin","year":"2010","unstructured":"Zentilin L, Puligadda U, Lionetti V, Zacchigna S, Collesi C, Pattarini L, Ruozi G, Camporesi S, Sinagra G, Pepe M, Recchia FA, Giacca M (2010) Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J 24:1467\u20131478","journal-title":"FASEB J"},{"key":"8167_CR19","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1182\/blood-2006-09-047704","volume":"109","author":"M Kennedy","year":"2007","unstructured":"Kennedy M, D\u2019Souza SL, Lynch-Kattman M, Schwantz S, Keller G (2007) Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 109:2679\u20132687","journal-title":"Blood"},{"key":"8167_CR20","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCRESAHA.107.150201","volume":"101","author":"LS Ferreira","year":"2007","unstructured":"Ferreira LS, Gerecht S, Shieh HF, Watson N, Rupnick MA, Dallabrida SM, Vunjak-Novakovic G, Langer R (2007) Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo. Circ Res 101:286\u2013294","journal-title":"Circ Res"},{"key":"8167_CR21","doi-asserted-by":"crossref","first-page":"15885","DOI":"10.1073\/pnas.0907622106","volume":"106","author":"C Bearzi","year":"2009","unstructured":"Bearzi C, Leri A, Lo Monaco F, Rota M, Gonzalez A, Hosoda T, Pepe M, Qanud K, Ojaimi C, Bardelli S, D\u2019Amario D, D\u2019Alessandro DA, Michler RE, Dimmeler S, Zeiher AM, Urbanek K, Hintze TH, Kajstura J, Anversa P (2009) Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci USA 106:15885\u201315890","journal-title":"Proc Natl Acad Sci USA"},{"key":"8167_CR22","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuint.2009.07.007","volume":"55","author":"S Kranich","year":"2009","unstructured":"Kranich S, Hattermann K, Specht A, Lucius R, Mentlein R (2009) VEGFR-3\/Flt-4 mediates proliferation and chemotaxis in glial precursor cells. Neurochem Int 55:747\u2013753","journal-title":"Neurochem Int"},{"key":"8167_CR23","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1042\/BST0371228","volume":"37","author":"A Fantin","year":"2009","unstructured":"Fantin A, Maden CH, Ruhrberg C (2009) Neuropilin ligands in vascular and neuronal patterning. Biochem Soc Trans 37:1228\u20131232","journal-title":"Biochem Soc Trans"},{"key":"8167_CR24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.conb.2009.06.001","volume":"19","author":"RJ Pasterkamp","year":"2009","unstructured":"Pasterkamp RJ, Giger RJ (2009) Semaphorin function in neural plasticity and disease. Curr Opin Neurobiol 19:263\u2013274","journal-title":"Curr Opin Neurobiol"},{"key":"8167_CR25","doi-asserted-by":"crossref","first-page":"12151","DOI":"10.1523\/JNEUROSCI.1494-10.2010","volume":"30","author":"L Yu","year":"2010","unstructured":"Yu L, Zhou Y, Cheng S, Rao Y (2010) Plexin a-semaphorin-1a reverse signaling regulates photoreceptor axon guidance in Drosophila. J Neurosci 30:12151\u201312156","journal-title":"J Neurosci"},{"key":"8167_CR26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1101\/gad.1644008","volume":"22","author":"A Nukazuka","year":"2008","unstructured":"Nukazuka A, Fujisawa H, Inada T, Oda Y, Takagi S (2008) Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans. Genes Dev 22:1025\u20131036","journal-title":"Genes Dev"},{"key":"8167_CR27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neuron.2010.04.006","volume":"66","author":"A Bellon","year":"2010","unstructured":"Bellon A, Luchino J, Haigh K, Rougon G, Haigh J, Chauvet S, Mann F (2010) VEGFR2 (KDR\/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain. Neuron 66:205\u2013219","journal-title":"Neuron"},{"key":"8167_CR28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/ATVBAHA.108.179663","volume":"29","author":"N Ferrara","year":"2009","unstructured":"Ferrara N (2009) Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 29:789\u2013791","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"8167_CR29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nrclinonc.2009.64","volume":"6","author":"P Carmeliet","year":"2009","unstructured":"Carmeliet P, De Smet F, Loges S, Mazzone M (2009) Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol 6:315\u2013326","journal-title":"Nat Rev Clin Oncol"},{"key":"8167_CR30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/380435a0","volume":"380","author":"P Carmeliet","year":"1996","unstructured":"Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435\u2013439","journal-title":"Nature"},{"key":"8167_CR31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","volume":"380","author":"N Ferrara","year":"1996","unstructured":"Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O\u2019Shea KS, Powell-Braxton L, Hillan KJ, Moore MW (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439\u2013442","journal-title":"Nature"},{"key":"8167_CR32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/376066a0","volume":"376","author":"GH Fong","year":"1995","unstructured":"Fong GH, Rossant J, Gertsenstein M, Breitman ML (1995) Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66\u201370","journal-title":"Nature"},{"key":"8167_CR33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/376062a0","volume":"376","author":"F Shalaby","year":"1995","unstructured":"Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376:62\u201366","journal-title":"Nature"},{"key":"8167_CR34","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1113\/jphysiol.2008.164384","volume":"587","author":"IM Olfert","year":"2009","unstructured":"Olfert IM, Howlett RA, Tang K, Dalton ND, Gu Y, Peterson KL, Wagner PD, Breen EC (2009) Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol 587:1755\u20131767","journal-title":"J Physiol"},{"key":"8167_CR35","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1152\/japplphysiol.00221.2004","volume":"97","author":"K Tang","year":"2004","unstructured":"Tang K, Rossiter HB, Wagner PD, Breen EC (2004) Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol 97:1559\u20131566","journal-title":"J Appl Physiol"},{"key":"8167_CR36","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1471-4159.2010.06573.x","volume":"112","author":"YZ Le","year":"2010","unstructured":"Le YZ, Bai Y, Zhu M, Zheng L (2010) Temporal requirement of RPE-derived VEGF in the development of choroidal vasculature. J Neurochem 112:1584\u20131592","journal-title":"J Neurochem"},{"key":"8167_CR37","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1042\/BST0371193","volume":"37","author":"AF Bruns","year":"2009","unstructured":"Bruns AF, Bao L, Walker JH, Ponnambalam S (2009) VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis. Biochem Soc Trans 37:1193\u20131197","journal-title":"Biochem Soc Trans"},{"key":"8167_CR38","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1074\/jbc.M109.074930","volume":"285","author":"DG Nowak","year":"2010","unstructured":"Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO (2010) Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem 285:5532\u20135540","journal-title":"J Biol Chem"},{"key":"8167_CR39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.200906044","volume":"188","author":"TT Chen","year":"2010","unstructured":"Chen TT, Luque A, Lee S, Anderson SM, Segura T, Iruela-Arispe ML (2010) Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188:595\u2013609","journal-title":"J Cell Biol"},{"key":"8167_CR40","doi-asserted-by":"crossref","first-page":"18751","DOI":"10.1073\/pnas.0905010106","volume":"106","author":"M Saint-Geniez","year":"2009","unstructured":"Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D\u2019Amore PA (2009) An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci USA 106:18751\u201318756","journal-title":"Proc Natl Acad Sci USA"},{"key":"8167_CR41","doi-asserted-by":"crossref","first-page":"26031","DOI":"10.1016\/S0021-9258(18)35712-0","volume":"267","author":"KA Houck","year":"1992","unstructured":"Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N (1992) Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267:26031\u201326037","journal-title":"J Biol Chem"},{"key":"8167_CR42","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1074\/jbc.271.13.7788","volume":"271","author":"BA Keyt","year":"1996","unstructured":"Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, Vandlen R, Ferrara N (1996) The carboxyl-terminal domain (111\u2013165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem 271:7788\u201377895","journal-title":"J Biol Chem"},{"key":"8167_CR43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1523-1747.2000.00036.x","volume":"115","author":"G Lauer","year":"2000","unstructured":"Lauer G, Sollberg S, Cole M, Flamme I, Sturzebecher J, Mann K, Krieg T, Eming SA (2000) Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol 115:12\u201318","journal-title":"J Invest Dermatol"},{"key":"8167_CR44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2353\/ajpath.2006.050372","volume":"168","author":"D Roth","year":"2006","unstructured":"Roth D, Piekarek M, Paulsson M, Christ H, Bloch W, Krieg T, Davidson JM, Eming SA (2006) Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair. Am J Pathol 168:670\u2013684","journal-title":"Am J Pathol"},{"key":"8167_CR45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-5793(02)03545-7","volume":"531","author":"G Lauer","year":"2002","unstructured":"Lauer G, Sollberg S, Cole M, Krieg T, Eming SA (2002) Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage site. FEBS Lett 531:309\u2013313","journal-title":"FEBS Lett"},{"key":"8167_CR46","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1083\/jcb.200703052","volume":"179","author":"P Mineur","year":"2007","unstructured":"Mineur P, Colige AC, Deroanne CF, Dubail J, Kesteloot F, Habraken Y, Noel A, Voo S, Waltenberger J, Lapiere CM, Nusgens BV, Lambert CA (2007) Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents. J Cell Biol 179:1261\u20131273","journal-title":"J Cell Biol"},{"key":"8167_CR47","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1242\/jcs.016410","volume":"121","author":"DG Nowak","year":"2008","unstructured":"Nowak DG, Woolard J, Amin EM, Konopatskaya O, Saleem MA, Churchill AJ, Ladomery MR, Harper SJ, Bates DO (2008) Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors. J Cell Sci 121:3487\u20133495","journal-title":"J Cell Sci"},{"key":"8167_CR48","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1101\/gad.322904","volume":"18","author":"Q Schwarz","year":"2004","unstructured":"Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C (2004) Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev 18:2822\u20132834","journal-title":"Genes Dev"},{"key":"8167_CR49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4248\/IJOS10006","volume":"2","author":"Z Zhang","year":"2010","unstructured":"Zhang Z, Helman JI, Li LJ (2010) Lymphangiogenesis, lymphatic endothelial cells and lymphatic metastasis in head and neck cancer\u2014a review of mechanisms. Int J Oral Sci 2:5\u201314","journal-title":"Int J Oral Sci"},{"key":"8167_CR50","doi-asserted-by":"crossref","first-page":"F1656","DOI":"10.1152\/ajprenal.00275.2009","volume":"297","author":"J Muller-Deile","year":"2009","unstructured":"Muller-Deile J, Worthmann K, Saleem M, Tossidou I, Haller H, Schiffer M (2009) The balance of autocrine VEGF-A and VEGF-C determines podocyte survival. Am J Physiol Renal Physiol 297:F1656\u2013F1667","journal-title":"Am J Physiol Renal Physiol"},{"key":"8167_CR51","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20100379","volume":"428","author":"ZG Wang","year":"2010","unstructured":"Wang ZG, Puri TS, Quigg RJ (2010) Characterization of novel VEGF (vascular endothelial growth factor)-C splicing isoforms from mouse. Biochem J 428:347\u2013354","journal-title":"Biochem J"},{"key":"8167_CR52","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/cne.22263","volume":"518","author":"JS Choi","year":"2010","unstructured":"Choi JS, Shin YJ, Lee JY, Yun H, Cha JH, Choi JY, Chun MH, Lee MY (2010) Expression of vascular endothelial growth factor receptor-3 mRNA in the rat developing forebrain and retina. J Comp Neurol 518:1064\u20131081","journal-title":"J Comp Neurol"},{"key":"8167_CR53","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nn1646","volume":"9","author":"B Bras Le","year":"2006","unstructured":"Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL (2006) VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci 9:340\u2013348","journal-title":"Nat Neurosci"},{"key":"8167_CR54","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ncb848","volume":"4","author":"TA Fulga","year":"2002","unstructured":"Fulga TA, Rorth P (2002) Invasive cell migration is initiated by guided growth of long cellular extensions. Nat Cell Biol 4:715\u2013719","journal-title":"Nat Cell Biol"},{"key":"8167_CR55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0925-4773(01)00510-X","volume":"109","author":"TI Heino","year":"2001","unstructured":"Heino TI, Karpanen T, Wahlstrom G, Pulkkinen M, Eriksson U, Alitalo K, Roos C (2001) The Drosophila VEGF receptor homolog is expressed in hemocytes. Mech Dev 109:69\u201377","journal-title":"Mech Dev"},{"key":"8167_CR56","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.devcel.2004.06.007","volume":"7","author":"K Bruckner","year":"2004","unstructured":"Bruckner K, Kockel L, Duchek P, Luque CM, Rorth P, Perrimon N (2004) The PDGF\/VEGF receptor controls blood cell survival in Drosophila. Dev Cell 7:73\u201384","journal-title":"Dev Cell"},{"key":"8167_CR57","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1387\/ijdb.041859am","volume":"48","author":"A Macias","year":"2004","unstructured":"Macias A, Romero NM, Martin F, Suarez L, Rosa AL, Morata G (2004) PVF1\/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia. Int J Dev Biol 48:1087\u20131094","journal-title":"Int J Dev Biol"},{"key":"8167_CR58","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1474-9726.2008.00380.x","volume":"7","author":"NH Choi","year":"2008","unstructured":"Choi NH, Kim JG, Yang DJ, Kim YS, Yoo MA (2008) Age-related changes in Drosophila midgut are associated with PVF2, a PDGF\/VEGF-like growth factor. Aging Cell 7:318\u2013334","journal-title":"Aging Cell"},{"key":"8167_CR59","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1073\/pnas.0915075107","volume":"107","author":"K Janssens","year":"2010","unstructured":"Janssens K, Sung HH, Rorth P (2010) Direct detection of guidance receptor activity during border cell migration. Proc Natl Acad Sci USA 107:7323\u20137328","journal-title":"Proc Natl Acad Sci USA"},{"key":"8167_CR60","first-page":"59","volume":"43","author":"X Wu","year":"2010","unstructured":"Wu X, Liu N (2010) The role of Ang\/Tie signaling in lymphangiogenesis. Lymphology 43:59\u201372","journal-title":"Lymphology"},{"key":"8167_CR61","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/ISB-00190","volume":"5","author":"A Dormer","year":"2005","unstructured":"Dormer A, Beck G (2005) Evolutionary analysis of human vascular endothelial growth factor, angiopoietin, and tyrosine endothelial kinase involved in angiogenesis and immunity. In Silico Biol 5:323\u2013339","journal-title":"In Silico Biol"},{"key":"8167_CR62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.neuro.30.051606.094345","volume":"30","author":"S Banerjee","year":"2007","unstructured":"Banerjee S, Bhat MA (2007) Neuron-glial interactions in blood\u2013brain barrier formation. Annu Rev Neurosci 30:235\u2013258","journal-title":"Annu Rev Neurosci"},{"key":"8167_CR63","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF01224761","volume":"21","author":"NJ Abbott","year":"1992","unstructured":"Abbott NJ, Bundgaard M (1992) Electron-dense tracer evidence for a blood\u2013brain barrier in the cuttlefish Sepia officinalis. J Neurocytol 21:276\u2013294","journal-title":"J Neurocytol"},{"key":"8167_CR64","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1525-142X.2005.05040.x","volume":"7","author":"R Munoz-Chapuli","year":"2005","unstructured":"Munoz-Chapuli R, Carmona R, Guadix JA, Macias D, Perez-Pomares JM (2005) The origin of the endothelial cells: an evo\u2013devo approach for the invertebrate\/vertebrate transition of the circulatory system. Evol Dev 7:351\u2013358","journal-title":"Evol Dev"},{"key":"8167_CR65","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1525-142X.2008.00274.x","volume":"10","author":"F Gasparini","year":"2008","unstructured":"Gasparini F, Burighel P, Manni L, Zaniolo G (2008) Vascular regeneration and angiogenic-like sprouting mechanism in a compound ascidian is similar to vertebrates. Evol Dev 10:591\u2013605","journal-title":"Evol Dev"},{"key":"8167_CR66","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ydbio.2007.12.035","volume":"315","author":"S Tiozzo","year":"2008","unstructured":"Tiozzo S, Voskoboynik A, Brown FD, De Tomaso AW (2008) A conserved role of the VEGF pathway in angiogenesis of an ectodermally-derived vasculature. Dev Biol 315:243\u2013255","journal-title":"Dev Biol"},{"key":"8167_CR67","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bst0270629","volume":"27","author":"MP Wymann","year":"1999","unstructured":"Wymann MP, Pirola L, Katanaev VL, Bulgarelli-Leva G (1999) Phosphoinositide 3-kinase signalling: no lipids. Biochem Soc Trans 27:629\u2013634","journal-title":"Biochem Soc Trans"},{"key":"8167_CR68","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1038\/sj.onc.1203739","volume":"19","author":"SE Scanga","year":"2000","unstructured":"Scanga SE, Ruel L, Binari RC, Snow B, Stambolic V, Bouchard D, Peters M, Calvieri B, Mak TW, Woodgett JR, Manoukian AS (2000) The conserved PI3\u2032K\/PTEN\/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19:3971\u20133977","journal-title":"Oncogene"},{"key":"8167_CR69","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1126\/science.1068094","volume":"295","author":"H Stocker","year":"2002","unstructured":"Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann MP, Hemmings BA, Hafen E (2002) Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt\/PKB. Science 295:2088\u20132091","journal-title":"Science"},{"key":"8167_CR70","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.gde.2006.06.003","volume":"16","author":"D Dormann","year":"2006","unstructured":"Dormann D, Weijer CJ (2006) Chemotactic cell movement during Dictyostelium development and gastrulation. Curr Opin Genet Dev 16:367\u2013373","journal-title":"Curr Opin Genet Dev"},{"key":"8167_CR71","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrg1879","volume":"7","author":"JA Engelman","year":"2006","unstructured":"Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7:606\u2013619","journal-title":"Nat Rev Genet"},{"key":"8167_CR72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1242\/dmm.000117","volume":"1","author":"NJ Oviedo","year":"2008","unstructured":"Oviedo NJ, Pearson BJ, Levin M, Sanchez Alvarado A (2008) Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. Dis Model Mech 1:131\u2013143","journal-title":"Dis Model Mech"},{"key":"8167_CR73","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gene.2010.08.006","volume":"469","author":"D Zhang","year":"2010","unstructured":"Zhang D, Aravind L (2010) Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. Gene 469:18\u201330","journal-title":"Gene"},{"key":"8167_CR74","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0167-4781(99)00172-4","volume":"1447","author":"A Smith","year":"1999","unstructured":"Smith A, Alrubaie S, Coehlo C, Leevers SJ, Ashworth A (1999) Alternative splicing of the Drosophila PTEN gene. Biochim Biophys Acta 1447:313\u2013317","journal-title":"Biochim Biophys Acta"},{"key":"8167_CR75","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00427-003-0323-y","volume":"213","author":"T Kawashima","year":"2003","unstructured":"Kawashima T, Tokuoka M, Awazu S, Satoh N, Satou Y (2003) A genomewide survey of developmentally relevant genes in Ciona intestinalis. VIII. Genes for PI3K signaling and cell cycle. Dev Genes Evol 213:284\u2013290","journal-title":"Dev Genes Evol"},{"key":"8167_CR76","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCRESAHA.108.181818","volume":"103","author":"A Horowitz","year":"2008","unstructured":"Horowitz A, Simons M (2008) Branching morphogenesis. Circ Res 103:784\u2013795","journal-title":"Circ Res"},{"key":"8167_CR77","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.devcel.2008.01.020","volume":"14","author":"L Centanin","year":"2008","unstructured":"Centanin L, Dekanty A, Romero N, Irisarri M, Gorr TA, Wappner P (2008) Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting. Dev Cell 14:547\u2013558","journal-title":"Dev Cell"},{"key":"8167_CR78","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1083\/jcb.200302047","volume":"161","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 161:1163\u20131177","journal-title":"J Cell Biol"},{"key":"8167_CR79","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/gb-2009-10-2-r20","volume":"10","author":"D Sims","year":"2009","unstructured":"Sims D, Duchek P, Baum B (2009) PDGF\/VEGF signaling controls cell size in Drosophila. Genome Biol 10:R20","journal-title":"Genome Biol"},{"key":"8167_CR80","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature04923","volume":"442","author":"M Kamei","year":"2006","unstructured":"Kamei M, Saunders WB, Bayless KJ, Dye L, Davis GE, Weinstein BM (2006) Endothelial tubes assemble from intracellular vacuoles in vivo. Nature 442:453\u2013456","journal-title":"Nature"},{"key":"8167_CR81","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1182\/blood-2009-11-252692","volume":"115","author":"A Sacharidou","year":"2010","unstructured":"Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE (2010) Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events. Blood 115:5259\u20135269","journal-title":"Blood"},{"key":"8167_CR82","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cub.2009.02.057","volume":"19","author":"S Abraham","year":"2009","unstructured":"Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E, Marshall CJ, Mavria G (2009) VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation. Curr Biol 19:668\u2013674","journal-title":"Curr Biol"},{"key":"8167_CR83","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(03)00407-5","volume":"344","author":"MH Maurer","year":"2003","unstructured":"Maurer MH, Tripps WK, Feldmann RE Jr, Kuschinsky W (2003) Expression of vascular endothelial growth factor and its receptors in rat neural stem cells. Neurosci Lett 344:165\u2013168","journal-title":"Neurosci Lett"},{"key":"8167_CR84","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1523\/JNEUROSCI.21-10-03332.2001","volume":"21","author":"D Bagnard","year":"2001","unstructured":"Bagnard D, Vaillant C, Khuth ST, Dufay N, Lohrum M, Puschel AW, Belin MF, Bolz J, Thomasset N (2001) Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci 21:3332\u20133341","journal-title":"J Neurosci"},{"key":"8167_CR85","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1074\/jbc.M406613200","volume":"280","author":"K Brusselmans","year":"2005","unstructured":"Brusselmans K, Bono F, Collen D, Herbert JM, Carmeliet P, Dewerchin M (2005) A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. J Biol Chem 280:3493\u20133499","journal-title":"J Biol Chem"},{"key":"8167_CR86","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2353\/ajpath.2007.061237","volume":"171","author":"K Nishijima","year":"2007","unstructured":"Nishijima K, Ng YS, Zhong L, Bradley J, Schubert W, Jo N, Akita J, Samuelsson SJ, Robinson GS, Adamis AP, Shima DT (2007) Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol 171:53\u201367","journal-title":"Am J Pathol"},{"key":"8167_CR87","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0306-4522(00)00207-4","volume":"99","author":"KL Jin","year":"2000","unstructured":"Jin KL, Mao XO, Nagayama T, Goldsmith PC, Greenberg DA (2000) Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain. Neuroscience 99:577\u2013585","journal-title":"Neuroscience"},{"key":"8167_CR88","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1073\/pnas.97.18.10242","volume":"97","author":"KL Jin","year":"2000","unstructured":"Jin KL, Mao XO, Greenberg DA (2000) Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci USA 97:10242\u201310247","journal-title":"Proc Natl Acad Sci USA"},{"key":"8167_CR89","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0306-4522(03)00399-3","volume":"120","author":"J Widenfalk","year":"2003","unstructured":"Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, Olson L (2003) Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120:951\u2013960","journal-title":"Neuroscience"},{"key":"8167_CR90","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/jnr.21087","volume":"84","author":"Q Li","year":"2006","unstructured":"Li Q, Ford MC, Lavik EB, Madri JA (2006) Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study. J Neurosci Res 84:1656\u20131668","journal-title":"J Neurosci Res"},{"key":"8167_CR91","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.brainres.2005.12.037","volume":"1073\u20131074","author":"KH Jung","year":"2006","unstructured":"Jung KH, Chu K, Lee ST, Kim SJ, Sinn DI, Kim SU, Kim M, Roh JK (2006) Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Res 1073\u20131074:190\u2013201","journal-title":"Brain Res"},{"key":"8167_CR92","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.200308040","volume":"163","author":"H Zhang","year":"2003","unstructured":"Zhang H, Vutskits L, Pepper MS, Kiss JZ (2003) VEGF is a chemoattractant for FGF-2-stimulated neural progenitors. J Cell Biol 163:1375\u20131384","journal-title":"J Cell Biol"},{"key":"8167_CR93","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1523\/JNEUROSCI.0526-06.2006","volume":"26","author":"T Wada","year":"2006","unstructured":"Wada T, Haigh JJ, Ema M, Hitoshi S, Chaddah R, Rossant J, Nagy A, van der Kooy D (2006) Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. J Neurosci 26:6803\u20136812","journal-title":"J Neurosci"},{"key":"8167_CR94","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1016\/j.febslet.2006.09.053","volume":"580","author":"BK Kim","year":"2006","unstructured":"Kim BK, Kim SE, Shim JH, Woo DH, Gil JE, Kim SK, Kim JH (2006) Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells. FEBS Lett 580:5869\u20135874","journal-title":"FEBS Lett"},{"key":"8167_CR95","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2009.02.065","volume":"1268","author":"NO Schmidt","year":"2009","unstructured":"Schmidt NO, Koeder D, Messing M, Mueller FJ, Aboody KS, Kim SU, Black PM, Carroll RS, Westphal M, Lamszus K (2009) Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Res 1268:24\u201337","journal-title":"Brain Res"},{"key":"8167_CR96","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/02688690903506077","volume":"24","author":"Y Guo","year":"2010","unstructured":"Guo Y, Shi D, Li W, Liang C, Wang H, Ye Z, Hu L, Li Y (2010) Effects of cerebral microvascular endothelial cells and vascular endothelial growth factor on the proliferation and differentiation of NSCs: a comparative study. Br J Neurosurg 24:62\u201368","journal-title":"Br J Neurosurg"},{"key":"8167_CR97","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.expneurol.2004.12.022","volume":"192","author":"N Mani","year":"2005","unstructured":"Mani N, Khaibullina A, Krum JM, Rosenstein JM (2005) Astrocyte growth effects of vascular endothelial growth factor (VEGF) application to perinatal neocortical explants: receptor mediation and signal transduction pathways. Exp Neurol 192:394\u2013406","journal-title":"Exp Neurol"},{"key":"8167_CR98","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jnr.20321","volume":"79","author":"FY Sun","year":"2005","unstructured":"Sun FY, Guo X (2005) Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. J Neurosci Res 79:180\u2013184","journal-title":"J Neurosci Res"},{"key":"8167_CR99","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3171\/jns.2005.103.5.0853","volume":"103","author":"MJ Merrill","year":"2005","unstructured":"Merrill MJ, Oldfield EH (2005) A reassessment of vascular endothelial growth factor in central nervous system pathology. J Neurosurg 103:853\u2013868","journal-title":"J Neurosurg"},{"key":"8167_CR100","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.bbadis.2006.04.005","volume":"1762","author":"D Lambrechts","year":"2006","unstructured":"Lambrechts D, Carmeliet P (2006) VEGF at the neurovascular interface: therapeutic implications for motor neuron disease. Biochim Biophys Acta 1762:1109\u20131121","journal-title":"Biochim Biophys Acta"},{"key":"8167_CR101","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1212\/01.WNL.0000129913.44351.A3","volume":"62","author":"D Devos","year":"2004","unstructured":"Devos D, Moreau C, Lassalle P, Perez T, De Seze J, Brunaud-Danel V, Destee A, Tonnel AB, Just N (2004) Low levels of the vascular endothelial growth factor in CSF from early ALS patients. Neurology 62:2127\u20132129","journal-title":"Neurology"},{"key":"8167_CR102","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1471-2164-11-203","volume":"11","author":"A Brockington","year":"2010","unstructured":"Brockington A, Heath PR, Holden H, Kasher P, Bender FL, Claes F, Lambrechts D, Sendtner M, Carmeliet P, Shaw PJ (2010) Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta\/delta mouse model of amyotrophic lateral sclerosis. BMC Genomics 11:203","journal-title":"BMC Genomics"},{"key":"8167_CR103","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/dneu.20747","volume":"69","author":"JS Lunn","year":"2009","unstructured":"Lunn JS, Sakowski SA, Kim B, Rosenberg AA, Feldman EL (2009) Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration. Dev Neurobiol 69:871\u2013884","journal-title":"Dev Neurobiol"},{"key":"8167_CR104","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1523\/JNEUROSCI.1877-07.2007","volume":"27","author":"L Lu","year":"2007","unstructured":"Lu L, Zheng L, Viera L, Suswam E, Li Y, Li X, Estevez AG, King PH (2007) Mutant Cu\/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression. J Neurosci 27:7929\u20137938","journal-title":"J Neurosci"},{"key":"8167_CR105","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1093\/hmg\/ddm193","volume":"16","author":"R Lemmens","year":"2007","unstructured":"Lemmens R, Van Hoecke A, Hersmus N, Geelen V, D\u2019Hollander I, Thijs V, Van Den Bosch L, Carmeliet P, Robberecht W (2007) Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish. Hum Mol Genet 16:2359\u20132365","journal-title":"Hum Mol Genet"},{"key":"8167_CR106","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1523\/JNEUROSCI.4433-06.2007","volume":"27","author":"Y Wang","year":"2007","unstructured":"Wang Y, Mao XO, Xie L, Banwait S, Marti HH, Greenberg DA, Jin K (2007) Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J Neurosci 27:304\u2013307","journal-title":"J Neurosci"},{"key":"8167_CR107","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neures.2008.06.008","volume":"62","author":"S Sathasivam","year":"2008","unstructured":"Sathasivam S (2008) VEGF and ALS. Neurosci Res 62:71\u201377","journal-title":"Neurosci Res"},{"key":"8167_CR108","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1212\/01.wnl.0000227926.42370.04","volume":"67","author":"W Chen","year":"2006","unstructured":"Chen W, Saeed M, Mao H, Siddique N, Dellefave L, Hung WY, Deng HX, Sufit RL, Heller SL, Haines JL, Pericak-Vance M, Siddique T (2006) Lack of association of VEGF promoter polymorphisms with sporadic ALS. Neurology 67:508\u2013510","journal-title":"Neurology"},{"key":"8167_CR109","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.05.027","volume":"1053","author":"T Yasuhara","year":"2005","unstructured":"Yasuhara T, Shingo T, Muraoka K, Kameda M, Agari T, Wen Ji Y, Hayase H, Hamada H, Borlongan CV, Date I (2005) Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain Res 1053:10\u201318","journal-title":"Brain Res"},{"key":"8167_CR110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neulet.2007.05.033","volume":"421","author":"YY Tian","year":"2007","unstructured":"Tian YY, Tang CJ, Wang JN, Feng Y, Chen XW, Wang L, Qiao X, Sun SG (2007) Favorable effects of VEGF gene transfer on a rat model of Parkinson disease using adeno-associated viral vectors. Neurosci Lett 421:239\u2013244","journal-title":"Neurosci Lett"},{"key":"8167_CR111","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12640-009-9079-0","volume":"17","author":"DF Emerich","year":"2010","unstructured":"Emerich DF, Mooney DJ, Storrie H, Babu RS, Kordower JH (2010) Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington\u2019s disease. Neurotox Res 17:66\u201374","journal-title":"Neurotox Res"},{"key":"8167_CR112","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-0404.2006.00775.x","volume":"116","author":"I Mateo","year":"2007","unstructured":"Mateo I, Llorca J, Infante J, Rodriguez-Rodriguez E, Fernandez-Viadero C, Pena N, Berciano J, Combarros O (2007) Low serum VEGF levels are associated with Alzheimer\u2019s disease. Acta Neurol Scand 116:56\u201358","journal-title":"Acta Neurol Scand"},{"key":"8167_CR113","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0197-4580(01)00285-8","volume":"23","author":"E Tarkowski","year":"2002","unstructured":"Tarkowski E, Issa R, Sjogren M, Wallin A, Blennow K, Tarkowski A, Kumar P (2002) Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer\u2019s disease and vascular dementia. Neurobiol Aging 23:237\u2013243","journal-title":"Neurobiol Aging"},{"key":"8167_CR114","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1471-4159.2009.06426.x","volume":"112","author":"NS Patel","year":"2010","unstructured":"Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D (2010) Alzheimer\u2019s beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. J Neurochem 112:66\u201376","journal-title":"J Neurochem"},{"key":"8167_CR115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0197-4580(03)00111-8","volume":"25","author":"SP Yang","year":"2004","unstructured":"Yang SP, Bae DG, Kang HJ, Gwag BJ, Gho YS, Chae CB (2004) Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer\u2019s disease. Neurobiol Aging 25:283\u2013290","journal-title":"Neurobiol Aging"},{"key":"8167_CR116","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jns.2009.02.318","volume":"283","author":"R Bo Del","year":"2009","unstructured":"Del Bo R, Ghezzi S, Scarpini E, Bresolin N, Comi GP (2009) VEGF genetic variability is associated with increased risk of developing Alzheimer\u2019s disease. J Neurol Sci 283:66\u201368","journal-title":"J Neurol Sci"},{"key":"8167_CR117","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12017-009-8096-8","volume":"12","author":"S Landgren","year":"2010","unstructured":"Landgren S, Palmer MS, Skoog I, Minthon L, Wallin A, Andreasen N, Zetterberg M, Blennow K, Zetterberg H (2010) No association of VEGF polymorphims with Alzheimer\u2019s disease. Neuromolecular Med 12:224\u2013228","journal-title":"Neuromolecular Med"},{"key":"8167_CR118","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1161\/STROKEAHA.109.554394","volume":"40","author":"W Zhang","year":"2009","unstructured":"Zhang W, Sun K, Zhen Y, Wang D, Wang Y, Chen J, Xu J, Hu FB, Hui R (2009) VEGF receptor-2 variants are associated with susceptibility to stroke and recurrence. Stroke 40:2720\u20132726","journal-title":"Stroke"},{"key":"8167_CR119","first-page":"417","volume":"79","author":"R Issa","year":"1999","unstructured":"Issa R, Krupinski J, Bujny T, Kumar S, Kaluza J, Kumar P (1999) Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke. Lab Invest 79:417\u2013425","journal-title":"Lab Invest"},{"key":"8167_CR120","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1093\/brain\/awm118","volume":"130","author":"V Rigau","year":"2007","unstructured":"Rigau V, Morin M, Rousset MC, de Bock F, Lebrun A, Coubes P, Picot MC, Baldy-Moulinier M, Bockaert J, Crespel A, Lerner-Natoli M (2007) Angiogenesis is associated with blood\u2013brain barrier permeability in temporal lobe epilepsy. Brain 130:1942\u20131956","journal-title":"Brain"},{"key":"8167_CR121","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.nbd.2008.12.018","volume":"34","author":"J Marcon","year":"2009","unstructured":"Marcon J, Gagliardi B, Balosso S, Maroso M, Noe F, Morin M, Lerner-Natoli M, Vezzani A, Ravizza T (2009) Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis. Neurobiol Dis 34:121\u2013132","journal-title":"Neurobiol Dis"},{"key":"8167_CR122","first-page":"913","volume":"118","author":"Y Li","year":"2008","unstructured":"Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X (2008) VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest 118:913\u2013923","journal-title":"J Clin Invest"},{"key":"8167_CR123","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1096\/fj.05-4829fje","volume":"20","author":"E Kilic","year":"2006","unstructured":"Kilic E, Kilic U, Wang Y, Bassetti CL, Marti HH, Hermann DM (2006) The phosphatidylinositol-3 kinase\/Akt pathway mediates VEGF\u2019s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J 20:1185\u20131187","journal-title":"FASEB J"},{"key":"8167_CR124","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/00001756-200409150-00024","volume":"15","author":"RR Islamov","year":"2004","unstructured":"Islamov RR, Chintalgattu V, Pak ES, Katwa LC, Murashov AK (2004) Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury. Neuroreport 15:2117\u20132121","journal-title":"Neuroreport"},{"key":"8167_CR125","doi-asserted-by":"crossref","first-page":"e4987","DOI":"10.1371\/journal.pone.0004987","volume":"4","author":"HM Kim","year":"2009","unstructured":"Kim HM, Hwang DH, Lee JE, Kim SU, Kim BG (2009) Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury. PLoS One 4:e4987","journal-title":"PLoS One"},{"key":"8167_CR126","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2005.11.006","volume":"243","author":"JJ Su","year":"2006","unstructured":"Su JJ, Osoegawa M, Matsuoka T, Minohara M, Tanaka M, Ishizu T, Mihara F, Taniwaki T, Kira J (2006) Upregulation of vascular growth factors in multiple sclerosis: correlation with MRI findings. J Neurol Sci 243:21\u201330","journal-title":"J Neurol Sci"},{"key":"8167_CR127","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/glia.21026","volume":"58","author":"M Sasaki","year":"2010","unstructured":"Sasaki M, Lankford KL, Brown RJ, Ruddle NH, Kocsis JD (2010) Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor. Glia 58:1523\u20131531","journal-title":"Glia"},{"key":"8167_CR128","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1097-4652(199905)179:2<149::AID-JCP5>3.0.CO;2-2","volume":"179","author":"H Yamada","year":"1999","unstructured":"Yamada H, Yamada E, Hackett SF, Ozaki H, Okamoto N, Campochiaro PA (1999) Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina. J Cell Physiol 179:149\u2013156","journal-title":"J Cell Physiol"},{"key":"8167_CR129","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1242\/dev.02385","volume":"133","author":"T Hashimoto","year":"2006","unstructured":"Hashimoto T, Zhang XM, Chen BY, Yang XJ (2006) VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation. Development 133:2201\u20132210","journal-title":"Development"},{"key":"8167_CR130","doi-asserted-by":"crossref","first-page":"e3554","DOI":"10.1371\/journal.pone.0003554","volume":"3","author":"M Saint-Geniez","year":"2008","unstructured":"Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D\u2019Amore PA (2008) Endogenous VEGF is required for visual function: evidence for a survival role on muller cells and photoreceptors. PLoS One 3:e3554","journal-title":"PLoS One"},{"key":"8167_CR131","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1167\/iovs.08-2332","volume":"50","author":"M Rehak","year":"2009","unstructured":"Rehak M, Hollborn M, Iandiev I, Pannicke T, Karl A, Wurm A, Kohen L, Reichenbach A, Wiedemann P, Bringmann A (2009) Retinal gene expression and Muller cell responses after branch retinal vein occlusion in the rat. Invest Ophthalmol Vis Sci 50:2359\u20132367","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8167_CR132","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1167\/iovs.09-3691","volume":"51","author":"JM Barnett","year":"2010","unstructured":"Barnett JM, McCollum GW, Penn JS (2010) Role of cytosolic phospholipase A(2) in retinal neovascularization. Invest Ophthalmol Vis Sci 51:1136\u20131142","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8167_CR133","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2010.03.019","volume":"91","author":"SE Yanni","year":"2010","unstructured":"Yanni SE, McCollum GW, Penn JS (2010) Genetic deletion of COX-2 diminishes VEGF production in mouse retinal Muller cells. Exp Eye Res 91:34\u201341","journal-title":"Exp Eye Res"},{"key":"8167_CR134","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1093\/hmg\/ddn142","volume":"17","author":"BM Hogan","year":"2008","unstructured":"Hogan BM, Bussmann J, Wolburg H, Schulte-Merker S (2008) ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet 17:2424\u20132432","journal-title":"Hum Mol Genet"},{"key":"8167_CR135","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1242\/dmm.000513","volume":"1","author":"AV Gore","year":"2008","unstructured":"Gore AV, Lampugnani MG, Dye L, Dejana E, Weinstein BM (2008) Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Dis Model Mech 1:275\u2013281","journal-title":"Dis Model Mech"},{"key":"8167_CR136","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1242\/jcs.059329","volume":"123","author":"MG Lampugnani","year":"2010","unstructured":"Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci 123:1073\u20131080","journal-title":"J Cell Sci"},{"key":"8167_CR137","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1750-1326-4-49","volume":"4","author":"T Falk","year":"2009","unstructured":"Falk T, Zhang S, Sherman SJ (2009) Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson\u2019s disease. Mol Neurodegener 4:49","journal-title":"Mol Neurodegener"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-011-8167-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-011-8167-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-011-8167-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:20:33Z","timestamp":1740892833000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-011-8167-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,28]]},"references-count":137,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["8167"],"URL":"https:\/\/doi.org\/10.1007\/s12035-011-8167-3","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"type":"print","value":"0893-7648"},{"type":"electronic","value":"1559-1182"}],"subject":[],"published":{"date-parts":[[2011,1,28]]}}}