{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:27:54Z","timestamp":1791232074383,"version":"4.1.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s12035-012-8310-9","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T08:00:04Z","timestamp":1346400004000},"page":"588-604","source":"Crossref","is-referenced-by-count":86,"title":["Nerve Growth Factor and Alzheimer's Disease: New Facts for an Old Hypothesis"],"prefix":"10.1007","volume":"46","author":[{"given":"Antonino","family":"Cattaneo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Calissano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"8310_CR1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","volume":"217","author":"RT Bartus","year":"1982","unstructured":"Bartus RT, Dean RL 3rd, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408\u2013414","journal-title":"Science"},{"key":"8310_CR2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"A Goate","year":"1991","unstructured":"Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L et al (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704\u2013706","journal-title":"Nature"},{"key":"8310_CR3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","volume":"269","author":"E Levy-Lahad","year":"1995","unstructured":"Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K et al (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973\u2013977","journal-title":"Science"},{"key":"8310_CR4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","volume":"376","author":"EI Rogaev","year":"1995","unstructured":"Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T et al (1995) Familial Alzheimer's disease in kindreds with missesnse mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775\u2013778","journal-title":"Nature"},{"key":"8310_CR5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"R Sherrington","year":"1995","unstructured":"Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K et al (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754\u2013760","journal-title":"Nature"},{"key":"8310_CR6","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","volume":"393","author":"M Hutton","year":"1998","unstructured":"Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A et al (1998) Association of missense and 5\u2019-splice-site mutations in Tau with the inherited dementia FTDP-17. Nature 393:702\u2013705","journal-title":"Nature"},{"issue":"5580","key":"8310_CR7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353\u2013356","journal-title":"Science"},{"key":"8310_CR8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","volume":"120","author":"RE Tanzi","year":"2005","unstructured":"Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120:545\u2013555","journal-title":"Cell"},{"key":"8310_CR9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(08)70170-4","volume":"7","author":"T Wisniewski","year":"2008","unstructured":"Wisniewski T, Konietzko U (2008) Amyloid-beta immunization for Alzheimer's disease. Lancet Neurol 7:805\u2013811","journal-title":"Lancet Neurol"},{"issue":"9634","key":"8310_CR10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","volume":"372","author":"C Holmes","year":"2008","unstructured":"Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW et al (2008) Long term effects of Abeta 42 immunization in Alzheimer's disease: follow-up of a randomized placebo-controlled phase I trial. Lancet 372(9634):216\u2013223","journal-title":"Lancet"},{"key":"8310_CR11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(08)61047-8","volume":"372","author":"PH St George-Hyslop","year":"2008","unstructured":"St George-Hyslop PH, Morris JC (2008) Will anti-amyloid therapies work for Alzheimer's disease? Lancet 372:180\u2013182","journal-title":"Lancet"},{"issue":"9","key":"8310_CR12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nm.2460","volume":"17","author":"DJ Selkoe","year":"2011","unstructured":"Selkoe DJ (2011) Resolving controversies on the path to Alzheimer's therapeutics. Nat Med 17(9):1060\u20131065","journal-title":"Nat Med"},{"key":"8310_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nn.3028","volume":"15","author":"I Benilova","year":"2012","unstructured":"Benilova I, Karren E, De Strooper B (2012) The toxic A beta oligomers and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 15:1\u20139","journal-title":"Nat Neurosci"},{"key":"8310_CR14","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","volume":"298","author":"DJ Selkoe","year":"2002","unstructured":"Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298:789\u2013791","journal-title":"Science"},{"key":"8310_CR15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuron.2011.01.002","volume":"27","author":"TE Golde","year":"2011","unstructured":"Golde TE, Schneider LS, Koo EH (2011) Anti Abeta therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 27:203\u2013213","journal-title":"Neuron"},{"key":"8310_CR16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuron.2008.11.007","volume":"60","author":"SA Small","year":"2008","unstructured":"Small SA, Duff K (2008) Linking A\u03b2 and Tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 60:534\u2013542","journal-title":"Neuron"},{"key":"8310_CR17","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.3306916","volume":"237","author":"R Levi-Montalcini","year":"1987","unstructured":"Levi-Montalcini R (1987) The nerve growth factor 35 years later. Science 237:1154\u20131162","journal-title":"Science"},{"key":"8310_CR18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ana.410200302","volume":"20","author":"F Hefti","year":"1986","unstructured":"Hefti F, Weiner WJ (1986) Nerve growth factor and Alzheimer's disease. Ann Neurol 20:275\u2013281","journal-title":"Ann Neurol"},{"key":"8310_CR19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.20233","volume":"56","author":"SE Counts","year":"2004","unstructured":"Counts SE, Nadeem M, Wuu J, Ginsberg SD, Saragovi HU, Mufson EJ (2004) Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease. Ann Neurol 56:520\u2013531","journal-title":"Ann Neurol"},{"key":"8310_CR20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/1096-9861(20001106)427:1<19::AID-CNE2>3.0.CO;2-A","volume":"427","author":"EJ Mufson","year":"2000","unstructured":"Mufson EJ, Ma SY, Cochran EJ, Bennett DA, Beckett LA, Jaffar S, Saragovi HU, Kordower JH (2000) Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol 427:19\u201330","journal-title":"J Comp Neurol"},{"key":"8310_CR21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0169-328X(96)00193-3","volume":"42","author":"M Fahnestock","year":"1996","unstructured":"Fahnestock M, Scott SA, Jette N, Weingartner JA, Crutcher KA (1996) Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex. Brain Res Mol Brain Res 42:175\u2013178","journal-title":"Brain Res Mol Brain Res"},{"key":"8310_CR22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0166-2236(02)00038-3","volume":"26","author":"A Salehi","year":"2003","unstructured":"Salehi A, Delcroix JD, Mobley WC (2003) Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci 26:73\u201380","journal-title":"Trends Neurosci"},{"key":"8310_CR23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1601-183X.2007.00378.x","volume":"7","author":"K Schindowski","year":"2008","unstructured":"Schindowski K, Belarbi K, Buee L (2008) Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav 7:43\u201356","journal-title":"Genes Brain Behav"},{"key":"8310_CR24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.neuro.24.1.601","volume":"24","author":"EM Shooter","year":"2001","unstructured":"Shooter EM (2001) Early days of the nerve growth factor proteins. Annu Rev Neurosci 24:601\u2013629","journal-title":"Annu Rev Neurosci"},{"key":"8310_CR25","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1073\/pnas.0510645103","volume":"103","author":"MA Bruno","year":"2006","unstructured":"Bruno MA, Cuello AC (2006) Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. Proc Natl Acad Sci USA 103:6735\u20136740","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR26","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1126\/science.1065057","volume":"294","author":"R Lee","year":"2001","unstructured":"Lee R, Kermani P, Teng KK, Hempstead BL (2001) Regulation of cell survival by secreted proneurotrophins. Science 294:1945\u20131948","journal-title":"Science"},{"key":"8310_CR27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0079-6123(03)46007-X","volume":"146","author":"M Fahnestock","year":"2004","unstructured":"Fahnestock M, Yu G, Coughlin MD (2004) ProNGF: a neurotrophic or an apoptotic molecule? Prog Brain Res 146:101\u2013110","journal-title":"Prog Brain Res"},{"issue":"4","key":"8310_CR28","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/prot.22311","volume":"75","author":"F Paoletti","year":"2009","unstructured":"Paoletti F, Covaceuszach S, Konarev PV, Gonfloni S, Malerba F, Schwarz E, Svergun DI, Cattaneo A, Lamba D (2009) Intrinsic structural disorder of mouse proNGF. Proteins 75(4):990\u20131009","journal-title":"Proteins"},{"key":"8310_CR29","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature02319","volume":"427","author":"A Nykjaer","year":"2004","unstructured":"Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C et al (2004) Sortilin is essential for proNGFinduced neuronal cell death. Nature 427:843\u2013848","journal-title":"Nature"},{"key":"8310_CR30","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/mcne.2001.1016","volume":"18","author":"M Fahnestock","year":"2001","unstructured":"Fahnestock M, Michalski B, Xu B, Coughlin MD (2001) The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci 18:210\u2013220","journal-title":"Mol Cell Neurosci"},{"key":"8310_CR31","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/NEN.0b013e3181aed9e6","volume":"68","author":"MA Bruno","year":"2009","unstructured":"Bruno MA, Leon WC, Fragoso G, Mushynski WE, Almazan G, Cuello AC (2009) Amyloid \u03b2\u2013induced NGF dysmetabolism in Alzheimer disease. J Neuropathol Exp Neurol 68:857\u2013869","journal-title":"J Neuropathol Exp Neurol"},{"key":"8310_CR32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.conb.2005.01.004","volume":"15","author":"A Nykjaer","year":"2005","unstructured":"Nykjaer A, Willnow TE, Petersen CM (2005) p75NTR\u2014live or let die. Curr Opin Neurobiol 15:49\u201357","journal-title":"Curr Opin Neurobiol"},{"key":"8310_CR33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/156720506775697061","volume":"3","author":"BL Hempstead","year":"2006","unstructured":"Hempstead BL (2006) Dissecting the diverse actions of pro- and mature neurotrophins. Curr Alzheimer Res 3:19\u201324","journal-title":"Curr Alzheimer Res"},{"key":"8310_CR34","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1073\/pnas.97.12.6826","volume":"97","author":"S Capsoni","year":"2000","unstructured":"Capsoni S, Ugolini G, Comparini A, Ruberti F, Berardi N, Cattaneo A (2000) Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci USA 97:6826\u20136831","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR35","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1523\/JNEUROSCI.20-07-02589.2000","volume":"20","author":"F Ruberti","year":"2000","unstructured":"Ruberti F, Capsoni S, Comparini A, Di Daniel E, Franzot J, Gonfloni S, Rossi G, Berardi N, Cattaneo A (2000) Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. J Neurosci 20:2589\u20132601","journal-title":"J Neurosci"},{"key":"8310_CR36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-2007-11312","volume":"11","author":"N Berardi","year":"2007","unstructured":"Berardi N, Braschi C, Capsoni S, Cattaneo A, Maffei L (2007) Environmental enrichment delays the onset of memory deficits and reduces neuropathological hallmarks in a mouse model of Alzheimer-like neurodegeneration. J Alzheimers Dis 11:359\u2013370","journal-title":"J Alzheimers Dis"},{"key":"8310_CR37","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1073\/pnas.0500195102","volume":"102","author":"R Rosa De","year":"2005","unstructured":"De Rosa R, Garcia AA, Braschi C, Capsoni S, Maffei L, Berardi N, Cattaneo A (2005) Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci USA 102:3811\u20133816","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-2006-9106","volume":"9","author":"N Origlia","year":"2006","unstructured":"Origlia N, Capsoni S, Domenici L, Cattaneo A (2006) Time window in cholinomimetic ability to rescue long-term potentiation in neurodegenerating antinerve growth factor mice. J Alzheimers Dis 9:59\u201368","journal-title":"J Alzheimers Dis"},{"key":"8310_CR39","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1460-9568.2006.04996.x","volume":"24","author":"E Sola","year":"2006","unstructured":"Sola E, Capsoni S, Rosato-Siri M, Cattaneo A, Cherubini E (2006) Failure of nicotine-dependent enhancement of synaptic efficacy at Schaffer-collateral CA1 synapses of AD11 anti-nerve growth factor transgenic mice. Eur J Neurosci 24:1252\u20131264","journal-title":"Eur J Neurosci"},{"key":"8310_CR40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/mcne.2002.1163","volume":"21","author":"S Capsoni","year":"2002","unstructured":"Capsoni S, Giannotta S, Cattaneo A (2002) Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies. Mol Cell Neurosci 21:15\u201328","journal-title":"Mol Cell Neurosci"},{"key":"8310_CR41","doi-asserted-by":"crossref","first-page":"12432","DOI":"10.1073\/pnas.192442999","volume":"99","author":"S Capsoni","year":"2002","unstructured":"Capsoni S, Giannotta S, Cattaneo A (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci USA 99:12432\u201312437","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10571-006-9112-2","volume":"26","author":"S Capsoni","year":"2006","unstructured":"Capsoni S, Cattaneo A (2006) On the molecular basis linking nerve growth factor (NGF) to Alzheimer's disease. Cell Mol Neurobiol 26:619\u2013633","journal-title":"Cell Mol Neurobiol"},{"key":"8310_CR43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JAD-2008-15210","volume":"15","author":"A Cattaneo","year":"2008","unstructured":"Cattaneo A, Capsoni S, Paoletti F (2008) Towards noninvasive nerve growth factor therapies for Alzheimer's disease. J Alzheimers Dis 15:255\u2013283","journal-title":"J Alzheimers Dis"},{"key":"8310_CR44","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jmb.2008.06.008","volume":"381","author":"S Covaceuszach","year":"2008","unstructured":"Covaceuszach S, Cassetta A, Konarev PV, Gonfloni S, Rudolph R, Svergun DI, Lamba D, Cattaneo A (2008) Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J Mol Biol 381:881\u2013896","journal-title":"J Mol Biol"},{"issue":"27","key":"8310_CR45","doi-asserted-by":"crossref","first-page":"12299","DOI":"10.1073\/pnas.1007181107","volume":"107","author":"S Capsoni","year":"2010","unstructured":"Capsoni S, Tiveron C, Vignone D, Amato G, Cattaneo A (2010) Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci USA 107(27):12299\u201312304","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR46","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1523\/JNEUROSCI.3326-09.2010","volume":"30","author":"L Lagostena","year":"2010","unstructured":"Lagostena L, Rosato-Siri M, D'Onofrio M, Brandi R, Arisi I, Capsoni S, Franzot J, Cattaneo A, Cherubini E (2010) In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction. J Neurosci 30:885\u2013893","journal-title":"J Neurosci"},{"issue":"6","key":"8310_CR47","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neurobiolaging.2009.05.023","volume":"32","author":"M D'Onofrio","year":"2009","unstructured":"D'Onofrio M, Arisi I, Brandi R, Di Mambro A, Felsani A, Capsoni S, Cattaneo A (2009) Early inflammation and immune response mRNAs in the brain of AD11 anti\u2009\u2212\u2009NGF mice. Neurobiol Aging 32(6):1007\u20131022","journal-title":"Neurobiol Aging"},{"key":"8310_CR48","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.neurobiolaging.2006.08.014","volume":"28","author":"A Parachikova","year":"2007","unstructured":"Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW (2007) Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging 28:1821\u20131833","journal-title":"Neurobiol Aging"},{"key":"8310_CR49","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","volume":"131","author":"B Stevens","year":"2007","unstructured":"Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B et al (2007) The classical complement cascade mediates CNS synapse elimination. Cell 131:1164\u20131178","journal-title":"Cell"},{"issue":"5","key":"8310_CR50","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2174\/187152711796235032","volume":"10","author":"S Capsoni","year":"2011","unstructured":"Capsoni S, Brandi R, Arisi I, D'Onofrio M, Cattaneo A (2011) A dual mechanism linking NGF deprivation and early inflammation to Alzheimer's neurodegeneration in the AD11 anti-NGF mouse model. CNS Neurological Disorders Drug Targets 10(5):635\u2013647, Review","journal-title":"CNS Neurological Disorders Drug Targets"},{"key":"8310_CR51","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","volume":"57","author":"BV Zlokovic","year":"2008","unstructured":"Zlokovic BV (2008) The blood\u2013brain barrier in health and chronic neurodegenerative disorders. Neuron 57:178\u2013201","journal-title":"Neuron"},{"key":"8310_CR52","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1073\/pnas.90.23.10989","volume":"90","author":"S D'Mello","year":"1993","unstructured":"D'Mello S, Galli C, Ciotti MT, Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989\u201310993","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0306-4522(99)00397-8","volume":"95","author":"T Borsello","year":"2000","unstructured":"Borsello T, Di Luzio A, Ciotti MT, Calissano P, Galli C (2000) Granule neuron DNA damage following deafferentation in adult rats cerebellar cortex: a lesion model. Neuroscience 95:163\u2013171","journal-title":"Neuroscience"},{"key":"8310_CR54","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/156720506778249416","volume":"3","author":"S Cavallaro","year":"2006","unstructured":"Cavallaro S, Calissano P (2006) A genomic approach to investigate neuronal apoptosis. Current Alzheimer research 3:4\u201323","journal-title":"Current Alzheimer research"},{"key":"8310_CR55","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1523\/JNEUROSCI.15-02-01172.1995","volume":"15","author":"C Galli","year":"1995","unstructured":"Galli C, Meucci O, Scorziello A, Werge TM, Calissano P, Schettini G (1995) Apoptosis in cerebellar granule cells is blocked by high KCI, Forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J Neurosci 15:1172\u20131179","journal-title":"J Neurosci"},{"key":"8310_CR56","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1073\/pnas.95.3.1247","volume":"95","author":"C Galli","year":"1998","unstructured":"Galli C, Piccini A, Ciotti MT, Castellani L, Calissano P, Zaccheo D, Tabaton M (1998) Increased amyloidogenic secretion in cerebellar granule cells undergoing apoptosis. Proc Natl Acad Sci USA 95:1247\u20131252","journal-title":"Proc Natl Acad Sci USA"},{"issue":"18","key":"8310_CR57","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1523\/JNEUROSCI.18-18-07061.1998","volume":"18","author":"N Canu","year":"1998","unstructured":"Canu N, Dus L, Barbato C, Ciotti MT, Brancolini C, Rinaldi AM, Novak M, Cattaneo A, Bradbury A, Calissano P (1998) Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. J Neurosci 18(18):7061\u20137074","journal-title":"J Neurosci"},{"key":"8310_CR58","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.cdd.4401314","volume":"11","author":"G Amadoro","year":"2004","unstructured":"Amadoro G, Serafino AL, Barbato C, Ciotti MT, Sacco A, Calissano P, Canu N (2004) Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons. Cell Death and Differentiation 11:217\u2013230","journal-title":"Cell Death and Differentiation"},{"key":"8310_CR59","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1073\/pnas.0511065103","volume":"103","author":"G Amadoro","year":"2006","unstructured":"Amadoro G, Ciotti MT, Costanzi M, Cestari V, Calissano P, Canu N (2006) NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK\/MAPK activation. Proc Natl Acad Sci USA 103:2892\u20132897","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR60","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.bbabio.2008.07.004","volume":"1777","author":"A Atlante","year":"2008","unstructured":"Atlante A, Amadoro G, Bobba A, De Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S (2008) A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phoaphorylation acting at the level of the adenine nucleotide translocator. Biochim BiophisActa 1777:1289\u20131300","journal-title":"Biochim Biophis.Acta"},{"key":"8310_CR61","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0014-5793(99)01018-2","volume":"457","author":"A Bobba","year":"1999","unstructured":"Bobba A, Atlante A, Giannattasio S, Sgaramella G, Calissano P (1999) Marra E. Early release and subsequent caspase-mediated degradation of cytochrome c in apoptotic cerebellar granule cells. FEBS Lett 457:126\u2013130","journal-title":"FEBS Lett"},{"key":"8310_CR62","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1471-4159.2003.01863.x","volume":"86","author":"A Atlante","year":"2003","unstructured":"Atlante A, De Bari L, Bobba A, Marra E, Calissano P, Passarella S (2003) Cytochrome c, released from cerebellar granule cells undergoing apoptosis or excytotoxic death, can generate protonmotive force and drive ATP synthesis in isolated mitochondria. J Neurochem 86:591\u2013604","journal-title":"J Neurochem"},{"key":"8310_CR63","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1523\/JNEUROSCI.20-02-00589.2000","volume":"20","author":"N Canu","year":"2000","unstructured":"Canu N, Barbato C, Ciotti MT, Serafino A, Dus L, Calissano P (2000) Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. J Neurosci 20:589\u2013599","journal-title":"J Neurosci"},{"issue":"5","key":"8310_CR64","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1471-4159.2004.02956.x","volume":"92","author":"N Canu","year":"2005","unstructured":"Canu N, Tufi R, Serafino AL, Amadoro G, Ciotti MT, Calissano P (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J Neurochem 92(5):1228\u20131242","journal-title":"J Neurochem"},{"key":"8310_CR65","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1097\/00001756-200107200-00019","volume":"12","author":"MA Berardinis De","year":"2001","unstructured":"De Berardinis MA, Ciotti MT, Amadoro G, Galli C, Calissano P (2001) Transfer of the apoptotic message in sister cultures of cerebellar neurons. NeuroReport 12:2137\u20132140","journal-title":"NeuroReport"},{"issue":"7","key":"8310_CR66","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","volume":"73","author":"LA Greene","year":"1976","unstructured":"Greene LA (1976) Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73(7):2424\u20132428","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3233\/JAD-2008-13109","volume":"13","author":"C Matrone","year":"2008","unstructured":"Matrone C, Di Luzio A, Meli G, D'Aguanno S, Severini C, Ciotti MT, Cattaneo A, Calissano P (2008) Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells. J Alzheimers Dis 13:81\u201396","journal-title":"J Alzheimers Dis"},{"key":"8310_CR68","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0079-6123(02)36039-4","volume":"136","author":"JH Morrison","year":"2002","unstructured":"Morrison JH, Hof PR (2002) Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res 136:467\u2013486","journal-title":"Prog Brain Res"},{"key":"8310_CR69","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1073\/pnas.0806133105","volume":"105","author":"C Matrone","year":"2008","unstructured":"Matrone C, Ciotti MT, Mercanti D, Marolda R, Calissano P (2008) NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. Proc Natl Acad Sci USA 105:13139\u201313144","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"8310_CR70","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neurobiolaging.2009.06.005","volume":"32","author":"G Amadoro","year":"2009","unstructured":"Amadoro G, Corsetti V, Ciotti MT, Florenzano F, Capsoni S, Amato G, Calissano P (2009) Endogenous Ab causes cell death via early tau hyperphosphorylation. Neurobiology of Aging 32(6):969\u2013990","journal-title":"Neurobiology of Aging"},{"issue":"2","key":"8310_CR71","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jnr.1212","volume":"66","author":"SB Shelton","year":"2001","unstructured":"Shelton SB, Johnson GV (2001) Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells. J Neurosci Res 66(2):203\u2013213","journal-title":"J Neurosci Res"},{"key":"8310_CR72","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jnr.20734","volume":"83","author":"QL Ma","year":"2006","unstructured":"Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM (2006) Antibodies against amyloid reduce A oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res 83:374\u2013384","journal-title":"J Neurosci Res"},{"key":"8310_CR73","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuron.2004.07.003","volume":"43","author":"S Oddo","year":"2004","unstructured":"Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Ab immunotherapy leads to learance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43:321\u2013332","journal-title":"Neuron"},{"key":"8310_CR74","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1038\/sj.emboj.7601878","volume":"26","author":"E Magnani","year":"2007","unstructured":"Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos L, Splillantini MG (2007) Interaction of tau protein with the dynactin complex. EMBO J 26:4546\u20134554","journal-title":"EMBO J"},{"key":"8310_CR75","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1242\/jcs.01018","volume":"117","author":"Y Tatebayashi","year":"2004","unstructured":"Tatebayashi Y, Haque N, Tung YC, Iqbal K, Grundke-Iqbal I (2004) Role of tau phosphorylation by glycogen synthase kinase-3b in the regulation of organelle transport. J Cell Sci 117:1653\u20131663","journal-title":"J Cell Sci"},{"key":"8310_CR76","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1515\/REVNEURO.2006.17.6.581","volume":"17","author":"G Niewiadomska","year":"2006","unstructured":"Niewiadomska G, Baksalerska-Pazera M, Riedel G (2006) Cytoskeletal transport in the aging brain: focus on the cholinergic system. Rev Neurosci 17:581\u2013618","journal-title":"Rev Neurosci"},{"key":"8310_CR77","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1196\/annals.1342.026","volume":"1048","author":"G Niewiadomska","year":"2005","unstructured":"Niewiadomska G, Baksalerska-Pazera M, Riedel G (2005) Altered cellular distribution of phospho-tau proteins coincides with impaired retrograde axonal transport in neurons of aged rats. Ann N Y Acad Sci 1048:287\u2013295","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"8310_CR78","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","volume":"4","author":"MV Chao","year":"2003","unstructured":"Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signaling pathways. Nat Rev Neurosci 4(4):299\u2013309, Review","journal-title":"Nat Rev Neurosci"},{"key":"8310_CR79","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","volume":"72","author":"EJ Huang","year":"2003","unstructured":"Huang EJ, Reichardt LF (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72:609\u2013642","journal-title":"Annu Rev Biochem"},{"key":"8310_CR80","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1073\/pnas.0904998106","volume":"106","author":"C Matrone","year":"2009","unstructured":"Matrone C, Marolda R, Ciafr\u00e8 S, Ciotti MT, Mercanti D, Calissano P (2009) Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. Proc Natl Acad Sci USA 106:11358\u201311363","journal-title":"Proc Natl Acad Sci USA"},{"key":"8310_CR81","doi-asserted-by":"crossref","first-page":"18177","DOI":"10.1074\/jbc.M709715200","volume":"283","author":"CH Reynolds","year":"2008","unstructured":"Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM, Hanger DP, Anderton BH (2008) Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. J Biol Chem 283:18177\u201318186","journal-title":"J Biol Chem"},{"key":"8310_CR82","doi-asserted-by":"crossref","first-page":"35282","DOI":"10.1074\/jbc.M110785200","volume":"277","author":"C Russo","year":"2002","unstructured":"Russo C, Dolcini V, Salis S, Venezia V, Violani E, Carlo P, Zambrano N, Russo T, Schettini G (2002) Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc\/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. J Biol Chem 277:35282\u201335288","journal-title":"J Biol Chem"},{"issue":"9","key":"8310_CR83","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.molmed.2004.07.001","volume":"10","author":"JC Cruz","year":"2004","unstructured":"Cruz JC, Tsai LH (2004) Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med 10(9):452\u2013458, Review","journal-title":"Trends Mol Med"},{"issue":"1","key":"8310_CR84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1523\/JNEUROSCI.22-01-00010.2002","volume":"22","author":"R Williamson","year":"2002","unstructured":"Williamson R, Scales T, Clark BR, Gibb G, Reynolds CH, Kellie S, Bird IN, Varndell IM, Sheppard PW, Everall I, Anderton BH (2002) Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloidbeta peptide exposure: involvement of Src family protein kinases. J Neurosci 22(1):10\u201320","journal-title":"J Neurosci"},{"issue":"15","key":"8310_CR85","doi-asserted-by":"crossref","first-page":"14563","DOI":"10.1074\/jbc.M412957200","volume":"280","author":"N Zampieri","year":"2005","unstructured":"Zampieri N, Xu CF, Neubert TA, Chao MV (2005) Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. J Biol Chem 280(15):14563\u201314571","journal-title":"J Biol Chem"},{"issue":"3","key":"8310_CR86","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.str.2009.01.007","volume":"17","author":"H Li","year":"2009","unstructured":"Li H, Wolfe MS, Selkoe DJ (2009) Toward structural elucidation of the gammasecretase complex. Structure 17(3):326\u2013334, Review","journal-title":"Structure"},{"issue":"4","key":"8310_CR87","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/1073858408331376","volume":"15","author":"EJ Coulson","year":"2009","unstructured":"Coulson EJ, May LM, Sykes AM, Hamlin AS (2009) The Role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist 15(4):317\u2013323","journal-title":"Neuroscientist"},{"issue":"15","key":"8310_CR88","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1523\/JNEUROSCI.0350-08.2008","volume":"28","author":"A Sotthibundhu","year":"2009","unstructured":"Sotthibundhu A, Sykes AM, Fox B, Underwood CK, Thangnipon W, Coulson EJ (2009) Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci 28(15):3941\u20133946","journal-title":"J Neurosci"},{"issue":"3","key":"8310_CR89","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.mcn.2008.03.011","volume":"38","author":"V Corsetti","year":"2008","unstructured":"Corsetti V, Amadoro G, Gentile A, Capsoni S, Ciotti MT, Cencioni MT, Atlante A, Canu N, Rohn TT, Cattaneo A, Calissano P (2008) Identification of a caspasederived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Mol Cell Neurosci 38(3):381\u2013392","journal-title":"Mol Cell Neurosci"},{"issue":"2","key":"8310_CR90","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/1567205053585819","volume":"2","author":"FM Longo","year":"2005","unstructured":"Longo FM, Massa SM (2005) Neurotrophin receptor-based strategies for Alzheimer's disease. Curr Alzheimer Res 2(2):167\u2013169, Review","journal-title":"Curr Alzheimer Res"},{"key":"8310_CR91","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1523\/JNEUROSCI.1960-11.2011","volume":"31","author":"C Matrone","year":"2011","unstructured":"Matrone C, Barbagallo APM, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L (2011) APP is phosphorylated by TrkA and regulates NGF\/TrkA signaling. J Neurosci 31:11756\u201311761","journal-title":"J Neurosci"},{"key":"8310_CR92","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.2218531","volume":"250","author":"BA Yankner","year":"1990","unstructured":"Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of \u03b2A protein: reversal by tachykinin neuropeptides. Science 250:279\u2013282","journal-title":"Science"},{"key":"8310_CR93","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1523\/JNEUROSCI.23-13-05531.2003","volume":"23","author":"LD Plant","year":"2003","unstructured":"Plant LD, Boyle JP, Smith LF, Peers C, Pearson HA (2003) The production of \u03b2A peptide is a critical requirement for the visability of central neurons. J Neurosci 23:5531\u20135535","journal-title":"J Neurosci"},{"key":"8310_CR94","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1523\/JNEUROSCI.2692-08.2008","volume":"28","author":"D Puzzo","year":"2008","unstructured":"Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O (2008) pM \u03b2A positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 28:14537\u201314545","journal-title":"J Neurosci"},{"key":"8310_CR95","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1101\/lm.1310209","volume":"16","author":"A Garcia-Osta","year":"2009","unstructured":"Garcia-Osta A, Alberini C (2009) \u03b2A mediates memory formation. Learn Mem 16:267\u2013272","journal-title":"Learn Mem"},{"key":"8310_CR96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.molmed.2007.06.004","volume":"13","author":"MO Grimm","year":"2007","unstructured":"Grimm MO, Grimm HS, Hartmann T (2007) \u03b2A as a regulator of lipiod homeostasis. Trends Mol Med 13:337\u2013344","journal-title":"Trends Mol Med"},{"key":"8310_CR97","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nn.2433","volume":"12","author":"E Abramov","year":"2009","unstructured":"Abramov E, Dolev I, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) \u03b2A as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci 12:1567\u20131576","journal-title":"Nat Neurosci"},{"key":"8310_CR98","first-page":"83","volume":"212","author":"ML Giuffrida","year":"2010","unstructured":"Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A (2010) The moniomer state of \u03b2A: where the Alzheimer's disease protein meets physiology. Rev Neurosci 212:83\u201393","journal-title":"Rev Neurosci"},{"key":"8310_CR99","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1749-6632.1960.tb49963.x","volume":"85","author":"R Levi-Montalcini","year":"1960","unstructured":"Levi-Montalcini R, Cohen S (1960) Effects of the extract of the mouse submaxillary salivary glands on the sympathetic system of mammals. Ann N Y Acad Sci 85:324\u2013341","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"8310_CR100","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1523\/JNEUROSCI.04-12-02986.1984","volume":"4","author":"HK Yip","year":"1984","unstructured":"Yip HK, Rich KM, Lampe PA, Johnson EM Jr (1984) The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia. J Neurosci 4(12):2986\u20132992","journal-title":"J Neurosci"},{"key":"8310_CR101","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.neuro.29.051605.112929","volume":"29","author":"S Pezet","year":"2006","unstructured":"Pezet S, McMahon SB (2006) Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci 29:507\u2013538","journal-title":"Annu Rev Neurosci"},{"key":"8310_CR102","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000017069","volume":"9","author":"M Eriksdotter Jonhagen","year":"1998","unstructured":"Eriksdotter Jonhagen M, Nordberg A, Amberla K, Backman L, Ebendal T, Meyerson B, Olson L et al (1998) Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dement Geriatr Cogn Disord 9:246\u2013257","journal-title":"Dement Geriatr Cogn Disord"},{"key":"8310_CR103","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0074-7742(02)50083-0","volume":"50","author":"SC Apfel","year":"2002","unstructured":"Apfel SC (2002) Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? Int Rev Neurobiol 50:393\u2013413","journal-title":"Int Rev Neurobiol"},{"key":"8310_CR104","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","volume":"11","author":"MH Tuszynski","year":"2005","unstructured":"Tuszynski MH, Thal L, Pay M, HS U, Salmon DP, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J (2005) A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 11:551\u2013555","journal-title":"Nat Med"},{"key":"8310_CR105","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3233\/JAD-2009-0953","volume":"16","author":"S Capsoni","year":"2009","unstructured":"Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, Amato G, Cattaneo A (2009) Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice. J Alzheimers Dis 16:371\u2013388","journal-title":"J Alzheimers Dis"},{"key":"8310_CR106","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2174\/156720509787602870","volume":"6","author":"S Covaceuszach","year":"2009","unstructured":"Covaceuszach S, Capsoni S, Ugolini G, Spirito F, Vignone D, Cattaneo A (2009) Development of a noninvasive NGFbased therapy for Alzheimer's disease. Curr Alzheimer Res 6:158\u2013170","journal-title":"Curr Alzheimer Res"},{"key":"8310_CR107","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ng0896-485","volume":"13","author":"Y Indo","year":"1996","unstructured":"Indo Y, Tsuruta M, Hayashida Y, Karim MA, Ohta K, Kawano T, Mitsubuchi H, Tonoki H, Awaya Y, Matsuda I (1996) Mutations in the TRKA\/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet 13:485\u2013488","journal-title":"Nat Genet"},{"key":"8310_CR108","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/humu.1224","volume":"18","author":"Y Indo","year":"2001","unstructured":"Indo Y (2001) Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Hum Mutat 18:462\u2013471","journal-title":"Hum Mutat"},{"key":"8310_CR109","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/hmg\/ddh096","volume":"13","author":"E Einarsdottir","year":"2004","unstructured":"Einarsdottir E, Carlsson A, Minde J, Toolanen G, Svensson O, Solders G, Holmgren G, Holmberg D, Holmberg M (2004) A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Hum Mol Genet 13:799\u2013805","journal-title":"Hum Mol Genet"},{"key":"8310_CR110","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.bbrc.2009.11.146","volume":"391","author":"S Covaceuszach","year":"2010","unstructured":"Covaceuszach S, Capsoni S, Marinelli S, Pavone F, Ceci M, Ugolini G, Vignone D, Amato G, Paoletti F, Lamba D, Cattaneo A (2010) In vitro receptor binding properties of a \u201cpainless\u201d NGF mutein linked to hereditary sensory autonomic neuropathy type V. Biochem Biophys Res Commun 391:824\u2013829","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"8310_CR111","doi-asserted-by":"crossref","first-page":"e17321","DOI":"10.1371\/journal.pone.0017321","volume":"6","author":"S Capsoni","year":"2011","unstructured":"Capsoni S, Covaceuszach S, Marinelli S, Ceci M, Bernardo A, Minghetti L, Ugolini G, Pavone F, Cattaneo A (2011) Taking pain out of NGF: a \"painless\" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One 6(2):e17321","journal-title":"PLoS One"},{"key":"8310_CR112","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/35082088","volume":"411","author":"HH Chuang","year":"2001","unstructured":"Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411:957\u2013962","journal-title":"Nature"},{"key":"8310_CR113","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1083646","volume":"300","author":"ED Prescott","year":"2003","unstructured":"Prescott ED, Julius DA (2003) Modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300:1284\u20131288","journal-title":"Science"},{"issue":"5","key":"8310_CR114","doi-asserted-by":"crossref","first-page":"e37555","DOI":"10.1371\/journal.pone.0037555","volume":"7","author":"S Capsoni","year":"2012","unstructured":"Capsoni S et al (2012) Intranasal painless human nerve growth factor slows amyloid neurodegeneration and prevents memory deficits in APP x PS1 mice. PLoS One 7(5):e37555. doi: 10.1371\/journal.pone.0037555","journal-title":"PLoS One"},{"key":"8310_CR115","first-page":"371","volume":"16","author":"E Maria Di","year":"2012","unstructured":"Di Maria E, Giorgio E, Uliana V, Bonvicini C, Faravelli F, Cammarata S, Novello MC, Galimberti D, Scarpini E, Zanetti O, Gennarelli M, Tabaton M (2012) Possible influence of a non-synonimous polimorphism located in the NGF precursor on susceptibility to late-onset Alzheimer's disease and mild cognitive impairment. J Alzheimers Dis 16:371\u2013388","journal-title":"J Alzheimers Dis"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-012-8310-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-012-8310-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-012-8310-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T20:52:08Z","timestamp":1714337528000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-012-8310-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,1]]},"references-count":115,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["8310"],"URL":"https:\/\/doi.org\/10.1007\/s12035-012-8310-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,1]]}}}