{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:02:16Z","timestamp":1760853736942},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T00:00:00Z","timestamp":1375228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s12035-013-8517-4","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T07:25:12Z","timestamp":1375169112000},"page":"262-275","source":"Crossref","is-referenced-by-count":18,"title":["Does Restraining Nitric Oxide Biosynthesis Rescue from Toxins-Induced Parkinsonism and Sporadic Parkinson's Disease?"],"prefix":"10.1007","volume":"49","author":[{"given":"Satya Prakash","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharawan","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen Kumar","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manindra Nath","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarad Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendra Pratap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,31]]},"reference":[{"key":"8517_CR1","first-page":"69","volume":"43","author":"MP Singh","year":"2006","unstructured":"Singh MP, Patel S, Dikshit M, Gupta YK (2006) Contribution of genomics and proteomics in understanding the role of modifying factors in Parkinson's disease. Indian J Biochem Biophys 43:69\u201381","journal-title":"Indian J Biochem Biophys"},{"key":"8517_CR2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12035-012-8291-8","volume":"46","author":"S Yadav","year":"2012","unstructured":"Yadav S, Dixit A, Agrawal S, Singh A, Srivastava G, Singh AK, Srivastava PK, Prakash O, Singh MP (2012) Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis. Mol Neurobiol 46:495\u2013512","journal-title":"Mol Neurobiol"},{"key":"8517_CR3","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.bbadis.2013.03.019","volume":"1832","author":"A Dixit","year":"2013","unstructured":"Dixit A, Srivastava G, Verma D, Mishra M, Singh PK, Prakash O, Singh MP (2013) Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease. Biochim Biophys Acta 1832:1227\u20131240","journal-title":"Biochim Biophys Acta"},{"key":"8517_CR4","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1038\/sj.bjp.0706458","volume":"147","author":"S Moncada","year":"2006","unstructured":"Moncada S, Higgs EA (2006) The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147:S193\u2013S201","journal-title":"Br J Pharmacol"},{"key":"8517_CR5","first-page":"526","volume":"145","author":"M Jachymova","year":"2006","unstructured":"Jachymova M, Masters BS, Horky K, Zima T, Martasek P (2006) Nitric oxide synthase, typical flavohemoproteins and their complicated enzymology. Cas Lek Cesk 145:526\u2013531","journal-title":"Cas Lek Cesk"},{"key":"8517_CR6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.niox.2009.03.001","volume":"20","author":"L Zhou","year":"2009","unstructured":"Zhou L, Zhu DY (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 20:223\u2013230","journal-title":"Nitric Oxide"},{"issue":"5090","key":"8517_CR7","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1126\/science.1361684","volume":"258","author":"E Culotta","year":"1992","unstructured":"Culotta E, Koshland DE Jr (1992) NO news is good news. (nitric oxide; includes information about other significant advances & discoveries of 1992) (Molecule of the Year). Science 258(5090):1862\u20131864","journal-title":"Science"},{"key":"8517_CR8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.niox.2006.07.003","volume":"15","author":"R Kavya","year":"2006","unstructured":"Kavya R, Saluja R, Singh S, Dikshit M (2006) Nitric oxide synthase regulation and diversity: implications in Parkinson's disease. Nitric Oxide 15:280\u2013294","journal-title":"Nitric Oxide"},{"key":"8517_CR9","first-page":"61","volume":"32","author":"EC Chinje","year":"1997","unstructured":"Chinje EC, Stratford IJ (1997) Role of nitric oxide in growth of solid tumours: a balancing act. Essays Biochem 32:61\u201372","journal-title":"Essays Biochem"},{"key":"8517_CR10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0076-6879(96)68033-1","volume":"268","author":"Q Liu","year":"1996","unstructured":"Liu Q, Gross SS (1996) Binding sites of nitric oxide synthases. Methods Enzymol 268:311\u2013324","journal-title":"Methods Enzymol"},{"key":"8517_CR11","doi-asserted-by":"crossref","first-page":"31020","DOI":"10.1074\/jbc.M203749200","volume":"277","author":"K Panda","year":"2002","unstructured":"Panda K, Rosenfeld RJ, Ghosh S, Meade AL, Getzoff ED, Stuehr DJ (2002) Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. J Biol Chem 277:31020\u201331030","journal-title":"J Biol Chem"},{"key":"8517_CR12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0968-0004(00)88973-2","volume":"20","author":"CP Ponting","year":"1995","unstructured":"Ponting CP, Phillips C (1995) DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. Trends Biochem Sci 20:102\u2013103","journal-title":"Trends Biochem Sci"},{"key":"8517_CR13","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1007\/s11064-008-9697-6","volume":"33","author":"K Aquilano","year":"2008","unstructured":"Aquilano K, Baldelli S, Rotilio G, Ciriolo MR (2008) Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res 33:2416\u20132426","journal-title":"Neurochem Res"},{"key":"8517_CR14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","volume":"298","author":"RG Knowles","year":"1994","unstructured":"Knowles RG, Moncada S (1994) Nitric oxide synthases in mammals. Biochem J 298:249\u2013258","journal-title":"Biochem J"},{"key":"8517_CR15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s13238-013-2116-z","volume":"4","author":"W Duan","year":"2013","unstructured":"Duan W, Zhou J, Li W, Zhou T, Chen Q, Yang F, Wei T (2013) Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase. Protein Cell 4:286\u2013298","journal-title":"Protein Cell"},{"key":"8517_CR16","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s11064-010-0176-5","volume":"35","author":"SP Gupta","year":"2010","unstructured":"Gupta SP, Patel S, Yadav S, Singh AK, Singh S, Singh MP (2010) Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation? Neurochem Res 35:1206\u20131213","journal-title":"Neurochem Res"},{"key":"8517_CR17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-079X.2010.00819.x","volume":"50","author":"NK Singhal","year":"2011","unstructured":"Singhal NK, Srivastava G, Patel DK, Jain SK, Singh MP (2011) Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. J Pineal Res 50:97\u2013109","journal-title":"J Pineal Res"},{"key":"8517_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5214\/ans.0972.7531.2005.120201","volume":"12","author":"R Kavya","year":"2005","unstructured":"Kavya R, Dikshit M (2005) Role of nitric oxide\/nitric oxide synthase in Parkinson's disease. Ann Neurosci 12:1\u20135","journal-title":"Ann Neurosci"},{"key":"8517_CR19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0248-4900(03)00004-2","volume":"95","author":"EJ Nelson","year":"2003","unstructured":"Nelson EJ, Connolly J, McArthur P (2003) Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism. Biol Cell 95:3\u20138","journal-title":"Biol Cell"},{"key":"8517_CR20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11064-006-9167-y","volume":"32","author":"KS Madhusoodanan","year":"2007","unstructured":"Madhusoodanan KS, Murad F (2007) NO-cGMP signaling and regenerative medicine involving stem cells. Neurochem Res 32:681\u2013694","journal-title":"Neurochem Res"},{"key":"8517_CR21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.expneurol.2012.08.024","volume":"238","author":"ED Hall","year":"2012","unstructured":"Hall ED, Wang JA, Miller DM (2012) Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury. Exp Neurol 238:176\u2013182","journal-title":"Exp Neurol"},{"key":"8517_CR22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbrc.2004.09.028","volume":"324","author":"M Chalimoniuk","year":"2004","unstructured":"Chalimoniuk M, Langfort J, Lukacova N, Marsala J (2004) Upregulation of guanylyl cyclase expression and activity in striatum of MPTP-induced parkinsonism in mice. Biochem Biophys Res Commun 324:118\u2013126","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"8517_CR23","doi-asserted-by":"crossref","first-page":"e30958","DOI":"10.1371\/journal.pone.0030958","volume":"7","author":"T Kanao","year":"2012","unstructured":"Kanao T, Sawada T, Davies SA, Ichinose H, Hasegawa K, Takahashi R, Hattori N, Imai Y (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS One 7(2):e30958","journal-title":"PLoS One"},{"key":"8517_CR24","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1523\/JNEUROSCI.3659-12.2013","volume":"33","author":"RM Cooke","year":"2013","unstructured":"Cooke RM, Mistry R, Challiss RA, Straub VA (2013) Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy. J Neurosci 33:5626\u20135637","journal-title":"J Neurosci"},{"key":"8517_CR25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1471-4159.2009.06147.x","volume":"110","author":"M Chalimoniuk","year":"2009","unstructured":"Chalimoniuk M, Stolecka A, Ziemi\u0144ska E, Stepie\u0144 A, Langfort J, Strosznajder JB (2009) Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism\u2014the possible key role of PKG. J Neurochem 110:307\u2013317","journal-title":"J Neurochem"},{"key":"8517_CR26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrm762","volume":"3","author":"S Moncada","year":"2002","unstructured":"Moncada S, Erusalimsky JD (2002) Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3:214\u2013220","journal-title":"Nat Rev Mol Cell Biol"},{"key":"8517_CR27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2013.03.008","volume":"32","author":"S Singh","year":"2013","unstructured":"Singh S, Zhuo M, Gorgun M, Englander EW (2013) Overexpressed neuroglobin raises threshold for nitric oxide-induced impairment of mitochondrial respiratory activities and stress signaling in primary cortical neurons. Nitric Oxide 32:21\u201328","journal-title":"Nitric Oxide"},{"key":"8517_CR28","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1161\/ATVBAHA.107.151167","volume":"27","author":"JD Erusalimsky","year":"2007","unstructured":"Erusalimsky JD, Moncada S (2007) Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol 27:2524\u20132531","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"8517_CR29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5607\/en.2013.22.1.11","volume":"22","author":"O Hwang","year":"2013","unstructured":"Hwang O (2013) Role of oxidative stress in Parkinson's disease. Exp Neurobiol 22:11\u201317","journal-title":"Exp Neurobiol"},{"key":"8517_CR30","doi-asserted-by":"crossref","first-page":"463756","DOI":"10.1155\/2012\/463756","volume":"2012","author":"MW Akhtar","year":"2012","unstructured":"Akhtar MW, Sunico CR, Nakamura T, Lipton SA (2012) Redox regulation of protein function via cysteine S-nitrosylation and its relevance to neurodegenerative diseases. Int J Cell Biol 2012:463756","journal-title":"Int J Cell Biol"},{"key":"8517_CR31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/bbrc.1996.1656","volume":"12","author":"JK Shergill","year":"1996","unstructured":"Shergill JK, Cammack R, Cooper CE, Cooper JM, Mann VM, Schapira AH (1996) Detection of nitrosyl complexes in human substantia nigra, in relation to Parkinson's disease. Biochem Biophys Res Commun 12:298\u2013305","journal-title":"Biochem Biophys Res Commun"},{"key":"8517_CR32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12640-009-9140-z","volume":"19","author":"W Zhang","year":"2011","unstructured":"Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, Hong JS, Sulzer D, Zecca L (2011) Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox Res 19:63\u201372","journal-title":"Neurotox Res"},{"key":"8517_CR33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1742-2094-9-241","volume":"9","author":"A Ghosh","year":"2012","unstructured":"Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka BP, Kalyanaraman B, Kanthasamy AG (2012) Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. J Neuroinflammation 9:241","journal-title":"J Neuroinflammation"},{"key":"8517_CR34","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.lfs.2012.10.003","volume":"91","author":"YH Sung","year":"2012","unstructured":"Sung YH, Kim SC, Hong HP, Park CY, Shin MS, Kim CJ, Seo JH, Kim DY, Kim DJ, Cho HJ (2012) Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice. Life Sci 91:1309\u20131316","journal-title":"Life Sci"},{"key":"8517_CR35","doi-asserted-by":"crossref","first-page":"436263","DOI":"10.1155\/2013\/436263","volume":"2013","author":"T Matsui","year":"2013","unstructured":"Matsui T, Motoki Y, Yoshida Y (2013) Hypothermia reduces toll-like receptor 3-activated microglial interferon-\u03b2 and nitric oxide production. Mediat Inflamm 2013:436263","journal-title":"Mediat Inflamm"},{"key":"8517_CR36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.20110698","volume":"209","author":"E Colombo","year":"2012","unstructured":"Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada LF, Medico E, Hohlfeld R, Meinl E, Farina C (2012) Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med 209:521\u2013535","journal-title":"J Exp Med"},{"key":"8517_CR37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneuroim.2013.03.006","volume":"259","author":"SU Kim","year":"2013","unstructured":"Kim SU, Park YH, Min JS, Sun HN, Han YH, Hua JM, Lee TH, Lee SR, Chang KT, Kang SW, Kim JM, Yu DY, Lee SH, Lee DS (2013) Peroxiredoxin I is a ROS\/p38 MAPK-dependent inducible antioxidant that regulates NF-\u03baB-mediated iNOS induction and microglial activation. J Neuroimmunol 259:26\u201336","journal-title":"J Neuroimmunol"},{"key":"8517_CR38","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.freeradbiomed.2009.07.013","volume":"47","author":"T Hoang","year":"2009","unstructured":"Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S (2009) Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radic Biol Med 47:1049\u20131056","journal-title":"Free Radic Biol Med"},{"key":"8517_CR39","first-page":"411","volume":"383","author":"CS Boyd","year":"2002","unstructured":"Boyd CS, Cadenas E (2002) Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem 383:411\u2013423","journal-title":"Biol Chem"},{"key":"8517_CR40","doi-asserted-by":"crossref","first-page":"19126","DOI":"10.1073\/pnas.0508215102","volume":"102","author":"C Perier","year":"2005","unstructured":"Perier C, Tieu K, Guegan C, Caspersen C, Jakson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S, Vila M (2005) Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci U S A 102:19126\u201319131","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8517_CR41","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.biopsych.2007.04.020","volume":"62","author":"S Guo","year":"2007","unstructured":"Guo S, Yan J, Yang T, Yang X, Bezard E, Zhao B (2007) Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway. Biol Psychiatry 62:1353\u20131362","journal-title":"Biol Psychiatry"},{"key":"8517_CR42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10048-008-0137-1","volume":"9","author":"DB Hancock","year":"2008","unstructured":"Hancock DB, Martin ER, Vance JM, Scott WK (2008) Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. Neurogenetics 9:249\u2013262","journal-title":"Neurogenetics"},{"key":"8517_CR43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10522-013-9421-z","volume":"14","author":"A Montesanto","year":"2013","unstructured":"Montesanto A, Crocco P, Tallaro F, Pisani F, Mazzei B, Mari V, Corsonello A, Lattanzio F, Passarino G, Rose G (2013) Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. Biogerontology 14:177\u2013186","journal-title":"Biogerontology"},{"key":"8517_CR44","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1212\/01.wnl.0000247672.41736.bd","volume":"67","author":"C Schulte","year":"2006","unstructured":"Schulte C, Sharma M, Mueller JC, Lichtner P, Prestel J, Berg D, Gasser T (2006) Comprehensive association analysis of the NOS2A gene with Parkinson disease. Neurology 67:2080\u20132082","journal-title":"Neurology"},{"key":"8517_CR45","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neulet.2006.11.044","volume":"413","author":"C Huerta","year":"2007","unstructured":"Huerta C, S\u00e1nchez-Ferrero E, Coto E, Bl\u00e1zquez M, Ribacoba R, Guisasola LM, Salvador C, Alvarez V (2007) No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes. Neurosci Lett 413:202\u2013205","journal-title":"Neurosci Lett"},{"key":"8517_CR46","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jnr.22045","volume":"87","author":"T Rife","year":"2009","unstructured":"Rife T, Rasoul B, Pullen N, Mitchell D, Grathwol K, Kurth J (2009) The effect of a promoter polymorphism on the transcription of nitric oxide synthase 1 and its relevance to Parkinson's disease. J Neurosci Res 87:2319\u20132325","journal-title":"J Neurosci Res"},{"key":"8517_CR47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-510X(01)00666-9","volume":"194","author":"HS Lo","year":"2002","unstructured":"Lo HS, Hogan EL, Soong BW (2002) 5\u2032-Flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan. J Neurol Sci 194:11\u201313","journal-title":"J Neurol Sci"},{"key":"8517_CR48","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ana.20915","volume":"60","author":"DB Hancock","year":"2006","unstructured":"Hancock DB, Martin ER, Fujiwara K, Stacy MA, Scott BL, Stajich JM, Jewett R, Li YJ, Hauser MA, Vance JM, Scott WK (2006) NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. Ann Neurol 60:366\u2013373","journal-title":"Ann Neurol"},{"key":"8517_CR49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/hmg\/ddg009","volume":"12","author":"C Levecque","year":"2003","unstructured":"Levecque C, Elbaz A, Clavel J, Richard F, Vidal JS, Amouyel P, Tzourio C, Alp\u00e9rovitch A, Chartier-Harlin MC (2003) Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case\u2013control study. Hum Mol Genet 12:79\u201386","journal-title":"Hum Mol Genet"},{"key":"8517_CR50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2008.09.026","volume":"400","author":"A Sinha","year":"2009","unstructured":"Sinha A, Srivastava N, Singh S, Singh AK, Bhushan S, Shukla R, Singh MP (2009) Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach. Clin Chim Acta 400:14\u201320","journal-title":"Clin Chim Acta"},{"key":"8517_CR51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12013-007-0014-9","volume":"47","author":"K Beyer","year":"2007","unstructured":"Beyer K (2007) Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane. Cell Biochem Biophys 47:285\u2013299","journal-title":"Cell Biochem Biophys"},{"key":"8517_CR52","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0003-9861(90)90680-W","volume":"283","author":"DW Reif","year":"1990","unstructured":"Reif DW, Simmons RD (1990) Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys 283:537\u2013541","journal-title":"Arch Biochem Biophys"},{"key":"8517_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2012.02.008","volume":"316","author":"KV Luong","year":"2012","unstructured":"Luong KV, Nguyen LT (2012) Thiamine and Parkinson's disease. J Neurol Sci 316:1\u20138","journal-title":"J Neurol Sci"},{"key":"8517_CR54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12035-010-8113-9","volume":"41","author":"Z Gu","year":"2010","unstructured":"Gu Z, Nakamura T, Lipton SA (2010) Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol 41:55\u201372","journal-title":"Mol Neurobiol"},{"key":"8517_CR55","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.1093891","volume":"304","author":"KK Chung","year":"2004","unstructured":"Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304:1328\u20131331","journal-title":"Science"},{"key":"8517_CR56","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1073\/pnas.0404161101","volume":"101","author":"D Yao","year":"2004","unstructured":"Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA (2004) Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A 101:10810\u201310814","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8517_CR57","doi-asserted-by":"crossref","first-page":"18742","DOI":"10.1073\/pnas.0705904104","volume":"104","author":"J Fang","year":"2007","unstructured":"Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA (2007) S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A 104:18742\u20131847","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8517_CR58","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/bies.10067","volume":"24","author":"R Betarbet","year":"2002","unstructured":"Betarbet R, Sherer TB, Greenamyre JT (2002) Animal models of Parkinson's disease. Bioessays 24:308\u2013318","journal-title":"Bioessays"},{"key":"8517_CR59","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/jnr.20012","volume":"75","author":"HJ Choi","year":"2004","unstructured":"Choi HJ, Lee SY, Cho Y, Hwang O (2004) JNK activation by tetrahydrobiopterin: implication for Parkinson's disease. J Neurosci Res 75:715\u2013721","journal-title":"J Neurosci Res"},{"key":"8517_CR60","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2008.12.081","volume":"1261","author":"I Joniec","year":"2009","unstructured":"Joniec I, Ciesielska A, Kurkowska-Jastrzebska I, Przybylkowski A, Czlonkowska A, Czlonkowski A (2009) Age and sex-differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res 1261:7\u201319","journal-title":"Brain Res"},{"key":"8517_CR61","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1089\/ars.2010.3570","volume":"14","author":"T Nakamura","year":"2011","unstructured":"Nakamura T, Lipton SA (2011) S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal 14:1479\u20131492","journal-title":"Antioxid Redox Signal"},{"key":"8517_CR62","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1073\/pnas.0511321103","volume":"103","author":"MR Hara","year":"2006","unstructured":"Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, Dawson TM, Sawa A, Snyder SH (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A 103:3887\u20133889","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8517_CR63","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1248\/bpb.b12-00127","volume":"35","author":"HG Kim","year":"2012","unstructured":"Kim HG, Ju MS, Ha SK, Lee H, Lee H, Kim SY, Oh MS (2012) Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biol Pharm Bull 35:1287\u20131294","journal-title":"Biol Pharm Bull"},{"key":"8517_CR64","doi-asserted-by":"crossref","first-page":"e38113","DOI":"10.1371\/journal.pone.0038113","volume":"7","author":"A Roy","year":"2012","unstructured":"Roy A, Ghosh A, Jana A, Liu X, Brahmachari S, Gendelman HE, Pahan K (2012) Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PLoS One 7:e38113","journal-title":"PLoS One"},{"key":"8517_CR65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1749-6632.2008.03678.x","volume":"1155","author":"V Matteo Di","year":"2009","unstructured":"Di Matteo V, Pierucci M, Benigno A, Crescimanno G, Esposito E, Di Giovanni G (2009) Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study. Ann N Y Acad Sci 1155:309\u2013315","journal-title":"Ann N Y Acad Sci"},{"key":"8517_CR66","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.neuropharm.2012.07.031","volume":"63","author":"JE Yuste","year":"2012","unstructured":"Yuste JE, Echeverry MB, Ros-Bernal F, Gomez A, Ros CM, Campuzano CM, Fernandez-Villalba E, Herrero MT (2012) 7-Nitroindazole down-regulates dopamine\/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease. Neuropharmacology 63:1258\u20131267","journal-title":"Neuropharmacology"},{"key":"8517_CR67","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1179\/174329210X12650506623447","volume":"15","author":"S Singh","year":"2010","unstructured":"Singh S, Kumar S, Dikshit M (2010) Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide. Redox Rep 15:115\u2013122","journal-title":"Redox Rep"},{"key":"8517_CR68","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1179\/135100005X38842","volume":"10","author":"S Singh","year":"2005","unstructured":"Singh S, Das T, Ravindran A, Chaturvedi RK, Shukla Y, Agarwal AK, Dikshit M (2005) Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson's disease. Redox Rep 10:103\u2013109","journal-title":"Redox Rep"},{"key":"8517_CR69","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12031-012-9814-5","volume":"48","author":"M Li","year":"2012","unstructured":"Li M, Dai FR, Du XP, Yang QD, Chen Y (2012) Neuroprotection by silencing iNOS expression in a 6-OHDA model of Parkinson's disease. J Mol Neurosci 48:225\u2013233","journal-title":"J Mol Neurosci"},{"key":"8517_CR70","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.freeradbiomed.2010.12.026","volume":"50","author":"L Broom","year":"2011","unstructured":"Broom L, Marinova-Mutafchieva L, Sadeghian M, Davis JB, Medhurst AD, Dexter DT (2011) Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free Radic Biol Med 50:633\u2013640","journal-title":"Free Radic Biol Med"},{"key":"8517_CR71","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11064-008-9656-2","volume":"34","author":"RL Miller","year":"2009","unstructured":"Miller RL, James-Kracke M, Sun GY, Sun AY (2009) Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res 34:55\u201365","journal-title":"Neurochem Res"},{"key":"8517_CR72","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2741\/2128","volume":"12","author":"C Gomez","year":"2007","unstructured":"Gomez C, Bandez MJ, Navarro A (2007) Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci 12:1079\u20131093","journal-title":"Front Biosci"},{"key":"8517_CR73","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3109\/10408444.2012.680431","volume":"42","author":"N Xiong","year":"2012","unstructured":"Xiong N, Long X, Xiong J, Jia M, Chen C, Huang J, Ghoorah D, Kong X, Lin Z, Wang T (2012) Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models. Crit Rev Toxicol 42:613\u2013632","journal-title":"Crit Rev Toxicol"},{"key":"8517_CR74","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neures.2011.08.008","volume":"71","author":"AA Abdin","year":"2011","unstructured":"Abdin AA, Sarhan NI (2011) Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of \u03b1-lipoic acid against rotenone-induced parkinsonism and l-dopa toxicity. Neurosci Res 71:387\u2013395","journal-title":"Neurosci Res"},{"key":"8517_CR75","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1016\/j.lfs.2003.06.013","volume":"73","author":"S Tada-Oikawa","year":"2003","unstructured":"Tada-Oikawa S, Hiraku Y, Kawanishi M, Kawanishi S (2003) Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis. Life Sci 73:3277\u20133288","journal-title":"Life Sci"},{"key":"8517_CR76","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1046\/j.1471-4159.2003.01938.x","volume":"86","author":"Y He","year":"2003","unstructured":"He Y, Imam SZ, Dong Z, Jankovic J, Ali SF, Appel SH, Le W (2003) Role of nitric oxide in rotenone-induced nigro-striatal injury. J Neurochem 86:1338\u20131345","journal-title":"J Neurochem"},{"key":"8517_CR77","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.expneurol.2003.12.005","volume":"186","author":"V Bashkatova","year":"2004","unstructured":"Bashkatova V, Alam M, Vanin A, Schmidt WJ (2004) Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain. Exp Neurol 186:235\u2013241","journal-title":"Exp Neurol"},{"key":"8517_CR78","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2010.11.117","volume":"404","author":"R Pal","year":"2011","unstructured":"Pal R, Miranda M, Narayan M (2011) Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention. Biochem Biophys Res Commun 404:324\u2013329","journal-title":"Biochem Biophys Res Commun"},{"key":"8517_CR79","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.nbd.2009.01.016","volume":"34","author":"JR Cannon","year":"2009","unstructured":"Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, Greenamyre JT (2009) A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis 34:279\u2013290","journal-title":"Neurobiol Dis"},{"key":"8517_CR80","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","volume":"9","author":"LF Hu","year":"2010","unstructured":"Hu LF, Lu M, Tiong CX, Dawe GS, Hu G, Bian JS (2010) Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging Cell 9:135\u2013146","journal-title":"Aging Cell"},{"key":"8517_CR81","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuint.2009.04.001","volume":"55","author":"R Verma","year":"2009","unstructured":"Verma R, Nehru B (2009) Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease. Neurochem Int 55:369\u2013375","journal-title":"Neurochem Int"},{"key":"8517_CR82","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuint.2008.12.003","volume":"54","author":"J Bi","year":"2009","unstructured":"Bi J, Jiang B, Hao S, Zhang A, Dong Y, Jiang T, An L (2009) Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons. Neurochem Int 54:264\u2013270","journal-title":"Neurochem Int"},{"key":"8517_CR83","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s11064-011-0682-0","volume":"37","author":"S Yadav","year":"2012","unstructured":"Yadav S, Gupta SP, Srivastava G, Srivastava PK, Singh MP (2012) Role of secondary mediators in caffeine-mediated neuroprotection in maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Neurochem Res 37:875\u2013884","journal-title":"Neurochem Res"},{"key":"8517_CR84","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/aje\/kwp006","volume":"169","author":"S Costello","year":"2009","unstructured":"Costello S, Cockburn M, Bronstein J, Zhang X, Ritz B (2009) Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. Am J Epidemiol 169:919\u2013926","journal-title":"Am J Epidemiol"},{"key":"8517_CR85","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.neurobiolaging.2011.02.016","volume":"33","author":"EN Mangano","year":"2012","unstructured":"Mangano EN, Litteljohn D, So R, Nelson E, Peters S, Bethune C, Bobyn J, Hayley S (2012) Interferon-\u03b3 plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways. Neurobiol Aging 33:1411\u20131426","journal-title":"Neurobiol Aging"},{"key":"8517_CR86","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1093\/hmg\/ddi413","volume":"14","author":"C Wang","year":"2005","unstructured":"Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL (2005) Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Hum Mol Genet 14:3885\u20133897","journal-title":"Hum Mol Genet"},{"key":"8517_CR87","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0168-0102(03)00163-9","volume":"46","author":"K Shimizu","year":"2003","unstructured":"Shimizu K, Matsubara K, Ohtaki K, Shiono H (2003) Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neurosci Res 46:523\u2013532","journal-title":"Neurosci Res"},{"key":"8517_CR88","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(03)02750-1","volume":"976","author":"K Shimizu","year":"2003","unstructured":"Shimizu K, Matsubara K, Ohtaki K, Fujimaru S, Saito O, Shiono H (2003) Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain Res 976:243\u2013252","journal-title":"Brain Res"},{"key":"8517_CR89","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/10715760802513733","volume":"42","author":"I Ahmad","year":"2008","unstructured":"Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C (2008) The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res 42:849\u2013862","journal-title":"Free Radic Res"},{"key":"8517_CR90","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.20-16-06309.2000","volume":"20","author":"WG Kim","year":"2000","unstructured":"Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20:6309\u20136316","journal-title":"J Neurosci"},{"key":"8517_CR91","doi-asserted-by":"crossref","first-page":"9820","DOI":"10.3390\/ijms14059820","volume":"14","author":"YY Lee","year":"2013","unstructured":"Lee YY, Park JS, Jung JS, Kim DH, Kim HS (2013) Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells. Int J Mol Sci 14:9820\u20139833","journal-title":"Int J Mol Sci"},{"key":"8517_CR92","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0969-9961(02)00017-7","volume":"12","author":"T Arimoto","year":"2003","unstructured":"Arimoto T, Bing G (2003) Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiol Dis 12:35\u201345","journal-title":"Neurobiol Dis"},{"key":"8517_CR93","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/sj.bjp.0705315","volume":"139","author":"G Girolamo Di","year":"2003","unstructured":"Di Girolamo G, Farina M, Riberio ML, Ogando D, Aisemberg J, De los Santos AR, Mart\u00ed ML, Franchi AM (2003) Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum. Br J Pharmacol 139:1164\u20131170","journal-title":"Br J Pharmacol"},{"key":"8517_CR94","doi-asserted-by":"crossref","first-page":"e5482","DOI":"10.1371\/journal.pone.0005482","volume":"4","author":"DY Choi","year":"2009","unstructured":"Choi DY, Liu M, Hunter RL, Cass WA, Pandya JD, Sullivan PG, Shin EJ, Kim HC, Gash DM, Bing G (2009) Striatal neuroinflammation promotes parkinsonism in rats. PLoS One 4:e5482","journal-title":"PLoS One"},{"key":"8517_CR95","doi-asserted-by":"crossref","first-page":"a009316","DOI":"10.1101\/cshperspect.a009316","volume":"1","author":"K Tieu","year":"2011","unstructured":"Tieu K (2011) A guide to neurotoxic animal models of Parkinson's disease. Cold Spring Harb Perspect Med 1:a009316","journal-title":"Cold Spring Harb Perspect Med"},{"key":"8517_CR96","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2004.08.008","volume":"204","author":"D Pubill","year":"2005","unstructured":"Pubill D, Chipana C, Camins A, Pall\u00e0s M, Camarasa J, Escubedo E (2005) Free radical production induced by methamphetamine in rat striatal synaptosomes. Toxicol Appl Pharmacol 204:57\u201368","journal-title":"Toxicol Appl Pharmacol"},{"key":"8517_CR97","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3727\/000000007783464975","volume":"16","author":"B Rajakumar","year":"2007","unstructured":"Rajakumar B, Flumerfelt BA, Hrycyshyn AW, Rajakumar N (2007) Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease. Cell Transplant 16:449\u2013459","journal-title":"Cell Transplant"},{"key":"8517_CR98","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1749-6632.1998.tb08227.x","volume":"844","author":"SF Ali","year":"1998","unstructured":"Ali SF, Itzhak Y (1998) Effects of 7-nitroindazole, an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice. Ann N Y Acad Sci 844:122\u2013130","journal-title":"Ann N Y Acad Sci"},{"key":"8517_CR99","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1177\/0269881110379282","volume":"25","author":"C Salum","year":"2011","unstructured":"Salum C, Issy AC, Brand\u00e3o ML, Guimar\u00e3es FS, Bel EA (2011) Nitric oxide modulates dopaminergic regulation of prepulse inhibition in the basolateral amygdala. J Psychopharmacol 25:1639\u20131648","journal-title":"J Psychopharmacol"},{"key":"8517_CR100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","volume":"20","author":"H Bernheimer","year":"1973","unstructured":"Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20:415\u2013455","journal-title":"J Neurol Sci"},{"key":"8517_CR101","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.neuroscience.2007.04.002","volume":"146","author":"A Bilska","year":"2007","unstructured":"Bilska A, Dubiel M, Soko\u0142owska-Jezewicz M, Lorenc-Koci E, W\u0142odek L (2007) Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience 146:1758\u20131771","journal-title":"Neuroscience"},{"key":"8517_CR102","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejphar.2006.02.004","volume":"535","author":"MT Tadaiesky","year":"2006","unstructured":"Tadaiesky MT, Andreatini R, Vital MA (2006) Different effects of 7-nitroindazole in reserpine-induced hypolocomotion in two strains of mice. Eur J Pharmacol 535:199\u2013207","journal-title":"Eur J Pharmacol"},{"key":"8517_CR103","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.neuroscience.2006.04.022","volume":"141","author":"M Chalimoniuk","year":"2006","unstructured":"Chalimoniuk M, Lukacova N, Marsala J, Langfort J (2006) Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience 141:1033\u20131046","journal-title":"Neuroscience"},{"key":"8517_CR104","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nm0996-1017","volume":"2","author":"P Hantraye","year":"1996","unstructured":"Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2:1017\u20131021","journal-title":"Nat Med"},{"issue":"12","key":"8517_CR105","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","volume":"5","author":"GT Liberatore","year":"1999","unstructured":"Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S (1999) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 5(12):1403\u20131409","journal-title":"Nat Med"},{"issue":"5","key":"8517_CR106","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1046\/j.1471-4159.2000.0742213.x","volume":"74","author":"T Dehmer","year":"2000","unstructured":"Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB (2000) Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74(5):2213\u20132216","journal-title":"J Neurochem"},{"key":"8517_CR107","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1073\/pnas.0810595106","volume":"106","author":"AH Tsang","year":"2009","unstructured":"Tsang AH, Lee YI, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KK (2009) S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease. Proc Natl Acad Sci U S A 106:4900\u20134905","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8517_CR108","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2012.06.070","volume":"523","author":"DK Stone","year":"2012","unstructured":"Stone DK, Kiyota T, Mosley RL, Gendelman HE (2012) A model of nitric oxide induced \u03b1-synuclein misfolding in Parkinson's disease. Neurosci Lett 523:167\u2013173","journal-title":"Neurosci Lett"},{"key":"8517_CR109","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1742-2094-8-44","volume":"8","author":"L Rojanathammanee","year":"2011","unstructured":"Rojanathammanee L, Murphy EJ, Combs CK (2011) Expression of mutant alpha-synuclein modulates microglial phenotype in vitro. J Neuroinflammation 8:44","journal-title":"J Neuroinflammation"},{"key":"8517_CR110","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1289\/ehp.1003013","volume":"119","author":"HM Gao","year":"2011","unstructured":"Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS (2011) Neuroinflammation and \u03b1-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect 119:807\u2013814","journal-title":"Environ Health Perspect"},{"key":"8517_CR111","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuroscience.2008.02.074","volume":"153","author":"RJ Phillips","year":"2008","unstructured":"Phillips RJ, Walter GC, Wilder SL, Baronowsky EA, Powley TL (2008) Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease? Neuroscience 153:733\u2013750","journal-title":"Neuroscience"},{"key":"8517_CR112","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST20120126","volume":"40","author":"C Manzoni","year":"2012","unstructured":"Manzoni C (2012) LRRK2 and autophagy: a common pathway for disease. Biochem Soc Trans 40:1147\u20131151","journal-title":"Biochem Soc Trans"},{"key":"8517_CR113","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuroscience.2012.02.001","volume":"208","author":"F Gillardon","year":"2012","unstructured":"Gillardon F, Schmid R, Draheim H (2012) Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity. Neuroscience 208:41\u201348","journal-title":"Neuroscience"},{"key":"8517_CR114","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ajpath.2012.10.027","volume":"182","author":"SJ Cherra 3rd","year":"2013","unstructured":"Cherra SJ 3rd, Steer E, Gusdon AM, Kiselyov K, Chu CT (2013) Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol 182:474\u2013484","journal-title":"Am J Pathol"},{"key":"8517_CR115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.nbd.2006.10.007","volume":"25","author":"HH Hoepken","year":"2007","unstructured":"Hoepken HH, Gispert S, Morales B, Wingerter O, Del Turco D, M\u00fclsch A, Nussbaum RL, M\u00fcller K, Dr\u00f6se S, Brandt U, Deller T, Wirth B, Kudin AP, Kunz WS, Auburger G (2007) Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 25:401\u2013411","journal-title":"Neurobiol Dis"},{"key":"8517_CR116","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2011.05.063","volume":"1404","author":"MJ Brzozowski","year":"2011","unstructured":"Brzozowski MJ, Alcantara SL, Iravani MM, Rose S, Jenner P (2011) The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression. Brain Res 1404:21\u201330","journal-title":"Brain Res"},{"key":"8517_CR117","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.0022-3042.2001.00710.x","volume":"80","author":"G Zorzi","year":"2002","unstructured":"Zorzi G, Thony B, Blau N (2002) Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency. J Neurochem 80:362\u2013644","journal-title":"J Neurochem"},{"key":"8517_CR118","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.brainres.2008.01.088","volume":"1203","author":"MZ Gomes","year":"2008","unstructured":"Gomes MZ, Raisman-Vozari R, Del Bel EA (2008) A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain Res 1203:160\u2013169","journal-title":"Brain Res"},{"key":"8517_CR119","first-page":"60","volume":"29","author":"C Shi","year":"2009","unstructured":"Shi C, Zhang YX, Zhang ZF (2009) Effect of phosphorylated-ERK1\/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease. Nan Fang Yi Ke Da Xue Xue Bao 29:60\u201363","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"8517_CR120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/138161211795164176","volume":"17","author":"E Del-Bel","year":"2011","unstructured":"Del-Bel E, Padovan-Neto FE, Raisman-Vozari R, Lazzarini M (2011) Role of nitric oxide in motor control: implications for Parkinson's disease pathophysiology and treatment. Curr Pharm Des 17:471\u2013488","journal-title":"Curr Pharm Des"},{"key":"8517_CR121","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2013.02.015","volume":"541","author":"FE Padovan-Neto","year":"2013","unstructured":"Padovan-Neto FE, Ferreira NR, Tavares D, de Aguiar D, Silva CA, Raisman-Vozari R, Del Bel E (2013) Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB\/DeltaFosB expression. Neurosci Lett 541:126\u2013131","journal-title":"Neurosci Lett"},{"key":"8517_CR122","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejphar.2012.03.008","volume":"683","author":"K Takuma","year":"2012","unstructured":"Takuma K, Tanaka T, Takahashi T, Hiramatsu N, Ota Y, Ago Y, Matsuda T (2012) Neuronal nitric oxide synthase inhibition attenuates the development of l-DOPA-induced dyskinesia in hemi-parkinsonian rats. Eur J Pharmacol 683:166\u2013173","journal-title":"Eur J Pharmacol"},{"key":"8517_CR123","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2174\/138955712800626674","volume":"12","author":"ME Camacho","year":"2012","unstructured":"Camacho ME, Carrion MD, Lopez-Cara LC, Entrena A, Gallo MA, Espinosa A, Escames G, Acuna-Castroviejo D (2012) Melatonin synthetic analogs as nitric oxide synthase inhibitors. Mini-Rev Med Chem 12:600\u2013617","journal-title":"Mini-Rev Med Chem"},{"key":"8517_CR124","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2010.04.020","volume":"39","author":"KD Dijk Van","year":"2010","unstructured":"Van Dijk KD, Teunissen CE, Drukarch B, Jimenez CR, Groenewegen HJ, Berendse HW, van de Berg WD (2010) Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approach. Neurobiol Dis 39:229\u2013241","journal-title":"Neurobiol Dis"},{"key":"8517_CR125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00335-011-9330-x","volume":"22","author":"PM Antony","year":"2011","unstructured":"Antony PM, Diederich NJ, Balling R (2011) Parkinson's disease mouse models in translational research. Mamm Genome 22:401\u2013419","journal-title":"Mamm Genome"},{"key":"8517_CR126","first-page":"658083","volume":"2011","author":"JA Potashkin","year":"2010","unstructured":"Potashkin JA, Blume SR, Runkle NK (2010) Limitations of animal models of Parkinson's disease. Park Dis 2011:658083","journal-title":"Park Dis"},{"key":"8517_CR127","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3164\/jcbn.11-28","volume":"50","author":"Z Luo","year":"2012","unstructured":"Luo Z, Zhao Y, Wang Y, Yang X, Zhao B (2012) Protective effect of theaflavins on neuron against 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells. J Clin Biochem Nutr 50:133\u2013138","journal-title":"J Clin Biochem Nutr"},{"key":"8517_CR128","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11481-012-9363-2","volume":"7","author":"RP Ojha","year":"2012","unstructured":"Ojha RP, Rastogi M, Devi BP, Agrawal A, Dubey GP (2012) Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Neuroimmune Pharmacol 7:609\u2013618","journal-title":"J Neuroimmune Pharmacol"},{"key":"8517_CR129","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00024382-199704000-00001","volume":"7","author":"RG Kilbourn","year":"1997","unstructured":"Kilbourn RG, Szab\u00f3 C, Traber DL (1997) Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons learned from experimental and clinical studies. Shock 7:235\u2013246","journal-title":"Shock"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-013-8517-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-013-8517-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-013-8517-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T17:16:22Z","timestamp":1715793382000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-013-8517-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,31]]},"references-count":129,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["8517"],"URL":"https:\/\/doi.org\/10.1007\/s12035-013-8517-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,31]]}}}