{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:28:39Z","timestamp":1793467719144,"version":"4.5.0"},"reference-count":232,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T00:00:00Z","timestamp":1380153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s12035-013-8553-0","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T15:53:58Z","timestamp":1380124438000},"page":"741-756","source":"Crossref","is-referenced-by-count":88,"title":["The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/cfs)"],"prefix":"10.1007","volume":"49","author":[{"given":"Gerwyn","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Galecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"8553_CR1","unstructured":"Morris G, Maes M (2012) A neuro\u2010immune model of myalgic encephalomyelitis\/chronic fatigue syndrome. Metab Brain Dis. 0885\u20107490"},{"key":"8553_CR2","volume-title":"ICD-10 classifications of mental and behavioural disorder: clinical descriptions and diagnostic guidelines","author":"World Health Organisation","year":"1992","unstructured":"World Health Organisation (1992) ICD-10 classifications of mental and behavioural disorder: clinical descriptions and diagnostic guidelines. World Health Organisation, Geneva"},{"key":"8553_CR3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2796.2011.02428.x","volume":"270","author":"BM Carruthers","year":"2011","unstructured":"Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles AC, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell DS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisbik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S (2011) Myalgic encephalomyelitis: international consensus criteria. J Intern Med 270:327\u2013338","journal-title":"J Intern Med"},{"key":"8553_CR4","first-page":"7","volume":"11","author":"BM Carruthers","year":"2003","unstructured":"Carruthers BM, Kumar Jain A, De Meirleir KL, Peterson DL, Klimas NG, Lerner AM, Bested AC, Flor-Henry P, Joshi P, Powles ACP, Sherkey JA, van de Sande MI (2003) Myalgic encephalomyelitis\/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. JCFS 11:7\u201397","journal-title":"JCFS"},{"key":"8553_CR5","doi-asserted-by":"crossref","first-page":"SC11","DOI":"10.12659\/MSM.881699","volume":"17","author":"M Maes","year":"2011","unstructured":"Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2011) Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Med Sci Monit 17:SC11\u2013SC15","journal-title":"Med Sci Monit"},{"key":"8553_CR6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.mehy.2012.07.034","volume":"79","author":"G Morris","year":"2012","unstructured":"Morris G, Maes M (2012) Increased nuclear factor-\u03baB and loss of p53 are key mechanisms in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Med Hypotheses 79:607\u2013613","journal-title":"Med Hypotheses"},{"key":"8553_CR7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000116723","volume":"216","author":"M Seishima","year":"2008","unstructured":"Seishima M, Mizutani Y, Shibuya Y, Arakawa C (2008) Chronic fatigue syndrome after human parvovirus B19 infection without persistent viremia. Dermatology 216:341\u2013346","journal-title":"Dermatology"},{"key":"8553_CR8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/jcp.2007.050054","volume":"61","author":"JK Chia","year":"2008","unstructured":"Chia JK, Chia AY (2008) Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach. J Clin Pathol 61:43\u201348","journal-title":"J Clin Pathol"},{"key":"8553_CR9","first-page":"5","volume":"14","author":"GL Nicolson","year":"2008","unstructured":"Nicolson GL, Nicolson NL, Haier J (2008) Chronic fatigue syndrome patients subsequently diagnosed with Lyme disease Borrelia burgdorferi: evidence for mycoplasma species co-infections. JCFS 14:5\u201317","journal-title":"JCFS"},{"key":"8553_CR10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1034\/j.1600-0463.2003.1110504.x","volume":"111","author":"GL Nicolson","year":"2003","unstructured":"Nicolson GL, Gan R, Haier J (2003) Multiple co-infections (Mycoplasma, Chlamydia, human herpesvirus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. APMIS 111:557\u2013566","journal-title":"APMIS"},{"key":"8553_CR11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF03257157","volume":"1","author":"KM Sleigh","year":"2002","unstructured":"Sleigh KM, Marra FH, Stiver HG (2002) Influenza vaccination: is it appropriate in chronic fatigue syndrome? Am J Respir Med 1:3\u20139","journal-title":"Am J Respir Med"},{"key":"8553_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-8-1","volume":"8","author":"EW Brenu","year":"2010","unstructured":"Brenu EW, Staines DR, Baskurt OK, Ashton KJ, Ramos SB, Christy RM, Marshall-Gradisnik SM (2010) Immune and hemorheological changes in chronic fatigue syndrome. J Transl Med 8:1","journal-title":"J Transl Med"},{"key":"8553_CR13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1479-5876-9-81","volume":"9","author":"EW Brenu","year":"2011","unstructured":"Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J, Klimas NG, Marshall-Gradisnik SM (2011) Immunological abnormalities as potential biomarkers in chronic fatigue syndrome\/myalgic encephalomyelitis. J Transl Med 9:81","journal-title":"J Transl Med"},{"key":"8553_CR14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1479-5876-10-88","volume":"10","author":"EW Brenu","year":"2012","unstructured":"Brenu EW, van Driel ML, Staines DR, Ashton KJ, Hardcastle SL, Keane J, Tajouri L, Peterson D, Ramos SB, Marshall-Gradisnik SM (2012) Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome\/myalgic encephalomyelitis. J Transl Med 10:88","journal-title":"J Transl Med"},{"key":"8553_CR15","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/JCM.28.6.1403-1410.1990","volume":"28","author":"N Klimas","year":"1990","unstructured":"Klimas N, Salvato F, Morgan R, Fletcher MA (1990) Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol 28:1403\u20131410","journal-title":"J Clin Microbiol"},{"key":"8553_CR16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/clin.1997.4512","volume":"87","author":"IS Hassan","year":"1998","unstructured":"Hassan IS, Bannister BA, Akbar A, Weir W, Bofill M (1998) A study of the immunology of the chronic fatigue syndrome: correlation of immunologic markers to health dysfunction. Clin Immunol Immunopathol 87:60\u201367","journal-title":"Clin Immunol Immunopathol"},{"key":"8553_CR17","first-page":"615","volume":"27","author":"M Maes","year":"2006","unstructured":"Maes M, Mihaylova I, Leunis JC (2006) Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins. Neuro Endocrinol Lett 27:615\u2013621","journal-title":"Neuro Endocrinol Lett"},{"key":"8553_CR18","first-page":"861","volume":"28","author":"M Maes","year":"2007","unstructured":"Maes M, Mihaylova I, Leunis JC (2007) Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression. Neuro Endocrinol Lett 28:861\u2013867","journal-title":"Neuro Endocrinol Lett"},{"issue":"9","key":"8553_CR19","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/nbm.2772","volume":"25","author":"DC Shungu","year":"2012","unstructured":"Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ (2012) Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 25(9):1073\u20131087","journal-title":"NMR Biomed"},{"key":"8553_CR20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.freeradbiomed.2005.04.020","volume":"39","author":"G Kennedy","year":"2005","unstructured":"Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 39:584\u2013589","journal-title":"Free Radic Biol Med"},{"key":"8553_CR21","first-page":"470","volume":"30","author":"M Maes","year":"2009","unstructured":"Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2009) Coenzyme Q10 deficiency in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME\/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 30:470\u2013476","journal-title":"Neuro Endocrinol Lett"},{"key":"8553_CR22","first-page":"677","volume":"30","author":"M Maes","year":"2009","unstructured":"Maes M, Twisk FN (2009) Why myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME\/CFS. Neuro Endocrinol Lett 30:677\u2013693","journal-title":"Neuro Endocrinol Lett"},{"key":"8553_CR23","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jad.2011.09.004","volume":"136","author":"M Maes","year":"2011","unstructured":"Maes M, Twisk FNM, Kubera M, Ringel K (2011) Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS): increased interleukin-1, tumor necrosis factor-\u03b1, PMN-elastase, lysozyme and neopterin. J Affect Disord 136:933\u2013939","journal-title":"J Affect Disord"},{"key":"8553_CR24","first-page":"463","volume":"28","author":"M Maes","year":"2007","unstructured":"Maes M, Mihaylova I, Kubera M, Bosmans E (2007) Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett 28:463\u2013469","journal-title":"Neuro Endocrinol Lett"},{"key":"8553_CR25","first-page":"456","volume":"28","author":"M Maes","year":"2007","unstructured":"Maes M, Mihaylova I, Bosmans E (2007) Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. Neuro Endocrinol Lett 28:456\u2013462","journal-title":"Neuro Endocrinol Lett"},{"key":"8553_CR26","first-page":"4717","volume":"29","author":"M Meeus","year":"2011","unstructured":"Meeus M, Mistiaen W, Lambrecht L, Nijs J (2011) Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue? Anticancer Res 29:4717\u20134726","journal-title":"Anticancer Res"},{"issue":"4","key":"8553_CR27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11011-012-9316-8","volume":"27","author":"M Maes","year":"2012","unstructured":"Maes M, Mihaylova I, Kubera M, Leunis JC, Twisk FN, Geffard M (2012) IgM-mediated autoimmune responses directed against anchorage epitopes are greater in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) than in major depression. Metab Brain Dis 27(4):415\u2013423","journal-title":"Metab Brain Dis"},{"key":"8553_CR28","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.psychres.2012.03.031","volume":"200","author":"M Maes","year":"2012","unstructured":"Maes M, Twisk FN, Johnson C (2012) Myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data. Psychiatry Res 200:754\u2013760","journal-title":"Psychiatry Res"},{"key":"8553_CR29","first-page":"307","volume":"25","author":"V Lombardi","year":"2011","unstructured":"Lombardi V, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA (2011) Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature. In Vivo 25:307\u2013314","journal-title":"In Vivo"},{"key":"8553_CR30","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jad.2011.09.010","volume":"136","author":"M Maes","year":"2012","unstructured":"Maes M, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M (2012) Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome. J Affect Disord 136:909\u2013917","journal-title":"J Affect Disord"},{"key":"8553_CR31","first-page":"745","volume":"26","author":"M Maes","year":"2005","unstructured":"Maes M, Mihaylova I, Leunis JC (2005) In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett 26:745\u2013751","journal-title":"Neuro Endocrinol Lett"},{"key":"8553_CR32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1479-5876-8-93","volume":"8","author":"RCW Vermuelen","year":"2010","unstructured":"Vermuelen RCW, Kurt RM, Visser FC, Sluiter W, Scholte HR (2010) Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med 8:93","journal-title":"J Transl Med"},{"key":"8553_CR33","first-page":"1","volume":"2","author":"S Myhill","year":"2009","unstructured":"Myhill S, Booth NE, McLaren-Howard J (2009) Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med 2:1\u201316","journal-title":"Int J Clin Exp Med"},{"key":"8553_CR34","first-page":"208","volume":"5","author":"NE Booth","year":"2012","unstructured":"Booth NE, Myhill S, McLaren-Howard J (2012) Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Int J Clin Exp Med 5:208\u2013220","journal-title":"Int J Clin Exp Med"},{"key":"8553_CR35","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1378\/chest.102.6.1716","volume":"102","author":"R Wong","year":"1992","unstructured":"Wong R, Lopaschuk G, Zhu G, Walker D, Catellier D, Burton D, Teo K, Collins-Nakai R, Montague T (1992) Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy. Chest 102:1716\u20131722","journal-title":"Chest"},{"key":"8553_CR36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000119233","volume":"32","author":"AV Plioplys","year":"1995","unstructured":"Plioplys AV, Plioplys S (1995) Electron-microscopic Investigation of muscle mitochondria in chronic fatigue syndrome. Neuropsychobiol 32:175\u2013181","journal-title":"Neuropsychobiol"},{"key":"8553_CR37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/014107689108400224","volume":"84","author":"MC Sharpe","year":"1991","unstructured":"Sharpe MC, Archard LC, Banatvala JE, Borysiewicz LK, Clare AW, David A, Edwards RH, Hawton KE, Lambert HP, Lane RJ, McDonald EM, Mowbray JF, Pearson DJ, Peto TEA, Preedy VR, Smith AP, Smith DG, Taylor DJ, Tyrrell AJ, Wessely S, White PD (1991) A report\u2014chronic fatigue syndrome: guidelines for research. JR Soc Med 84:118\u2013121","journal-title":"JR Soc Med"},{"key":"8553_CR38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2265.2001.01341.x","volume":"55","author":"AJ Cleare","year":"2001","unstructured":"Cleare AJ, O\u2019Keane V, Miell J (2001) Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion. Clin Endocrinol (Oxf) 55:113\u2013119","journal-title":"Clin Endocrinol (Oxf)"},{"key":"8553_CR39","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.coph.2007.10.010","volume":"7","author":"XY Lu","year":"2007","unstructured":"Lu XY (2007) The leptin hypothesis of depression: a potential link between mood disorders and obesity? Curr Opin Pharmacol 7:648\u2013652","journal-title":"Curr Opin Pharmacol"},{"issue":"1\u20133","key":"8553_CR40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jad.2007.07.024","volume":"107","author":"JA Pasco","year":"2008","unstructured":"Pasco JA, Jacka FN, Williams LJ, Henry MJ, Nicholson GC, Kotowicz MA, Berk M (2008) Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study. J Affect Disord 107(1\u20133):221\u2013225","journal-title":"J Affect Disord"},{"key":"8553_CR41","first-page":"117","volume":"11","author":"J Nijs","year":"2003","unstructured":"Nijs J, McGregor NR, De Becker P, Verhas M, Englebienne P, De Meirleir K (2003) Monitoring a hypothetical channelopathy in chronic fatigue syndrome: preliminary observations. JCFS 11:117\u2013133","journal-title":"JCFS"},{"key":"8553_CR42","first-page":"51","volume":"11","author":"J Nijs","year":"2003","unstructured":"Nijs J, Coomans D, Nicolson GL, De Becker P, Christian D, De Meirleir K (2003) Immunophenotyping predictive of Mycoplasma infection in patients with chronic fatigue syndrome. JCFS 11:51\u201369","journal-title":"JCFS"},{"key":"8553_CR43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1365-3083.1994.tb03511.x","volume":"40","author":"U Tirelli","year":"1994","unstructured":"Tirelli U, Marotta G, Improta S, Pinto A (1994) Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol 40:601\u2013608","journal-title":"Scand J Immunol"},{"key":"8553_CR44","doi-asserted-by":"crossref","unstructured":"Bradley AS, Ford B, Bansal AS (2013) Altered functional B-cell subset populations in patients with chronic fatigue syndrome compared to healthy controls. 172(1):73\u201380. doi: 10.1111\/cei.12043","DOI":"10.1111\/cei.12043"},{"key":"8553_CR45","first-page":"225","volume":"12","author":"S Tanaka","year":"2003","unstructured":"Tanaka S, Kuratsune H, Hidaka Y, Hakariya Y, Tatsumi KI, Takano T, Kanakura Y, Amino N (2003) Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome. Int J Mol Med 12:225\u2013230","journal-title":"Int J Mol Med"},{"key":"8553_CR46","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/art.1780341123","volume":"34","author":"MD Buchwald","year":"1991","unstructured":"Buchwald MD, Wener MH, Komaroff AL (1991) Antineuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities. Arthritis Rheum 34:1485\u20131486","journal-title":"Arthritis Rheum"},{"key":"8553_CR47","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1212\/WNL.48.6.1717","volume":"48","author":"AV Plioplys","year":"1997","unstructured":"Plioplys AV (1997) Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome. Neurology 48:1717\u20131719","journal-title":"Neurology"},{"key":"8553_CR48","first-page":"79","volume":"10","author":"N Bassi","year":"2008","unstructured":"Bassi N, Amital D, Amital H, Doria A, Shoenfeld Y (2008) Chronic fatigue syndrome: characteristics and possible causes for its pathogenesis. Isr Med Assoc J 10:79\u201382","journal-title":"Isr Med Assoc J"},{"key":"8553_CR49","first-page":"1067","volume":"65","author":"M Nishikai","year":"2007","unstructured":"Nishikai M (2007) Antinuclear antibodies in patients with chronic fatigue syndrome. Nippon Rinsho 65:1067\u20131070","journal-title":"Nippon Rinsho"},{"key":"8553_CR50","first-page":"784","volume":"35","author":"M Maes","year":"2010","unstructured":"Maes M (2010) An intriguing and hitherto unexplained co-occurrence: depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways. Prog Neuropsychopharmacol. Biol Psychiatry 35:784\u2013794","journal-title":"Biol Psychiatry"},{"key":"8553_CR51","first-page":"21","volume":"1","author":"R Klein","year":"1995","unstructured":"Klein R, Berg PA (1995) High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders. Eur J Med Res 1:21\u201326","journal-title":"Eur J Med Res"},{"key":"8553_CR52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, Karre K (1990) In search of the \u2018missing self\u2019: MHC molecules and NK cell recognition. Immunol Today 11:237\u2013244","journal-title":"Immunol Today"},{"key":"8553_CR53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.immunol.22.012703.104711","volume":"22","author":"WM Yokoyama","year":"2004","unstructured":"Yokoyama WM, Kim S, French AR (2004) The dynamic life of natural killer cells. Annu Rev Immunol 22:405\u2013429","journal-title":"Annu Rev Immunol"},{"key":"8553_CR54","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2119\/molmed.2009.00035","volume":"15","author":"A Lunemann","year":"2009","unstructured":"Lunemann A, Lunemann JD, Munz C (2009) Regulatory NK-cell functions in inflammation and autoimmunity. Mol Med 15:352\u2013358","journal-title":"Mol Med"},{"key":"8553_CR55","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.4049\/jimmunol.180.12.7785","volume":"180","author":"T Strowig","year":"2008","unstructured":"Strowig T, Brilot F, Munz C (2008) Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 180:7785\u20137791","journal-title":"J Immunol"},{"key":"8553_CR56","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1471-4906(01)01923-8","volume":"22","author":"J Zimmer","year":"2001","unstructured":"Zimmer J, Bausinger H, de la Salle H (2001) Autoimmunity mediated by innate immune effector cells. Trends Immunol 22:300\u2013301","journal-title":"Trends Immunol"},{"key":"8553_CR57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1471-4906(00)01821-4","volume":"22","author":"F Shi","year":"2001","unstructured":"Shi F, Ljunggren HG, Sarvetnick N (2001) Innate immunity and autoimmunity: from self-protection to self-destruction. Trends Immunol 22:97\u2013101","journal-title":"Trends Immunol"},{"key":"8553_CR58","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.4049\/jimmunol.163.3.1390","volume":"163","author":"RB Smeltz","year":"1999","unstructured":"Smeltz RB, Wolf NA, Swanborg RH (1999) Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: implications for autoimmunity. J Immunol 163:1390\u20131397","journal-title":"J Immunol"},{"key":"8553_CR59","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1681::AID-IMMU1681>3.0.CO;2-T","volume":"28","author":"Y Matsumoto","year":"1998","unstructured":"Matsumoto Y, Kohyama K, Aikawa Y, Shin T, Kawazoe Y, Suzuki Y, Tanuma N (1998) Role of natural killer cells and TCR\u03b3\u03b4 T cells in acute autoimmune encephalomyelitis. Eur J Immunol 28:1681\u20131688","journal-title":"Eur J Immunol"},{"key":"8553_CR60","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.4049\/jimmunol.165.6.3099","volume":"165","author":"FD Shi","year":"2000","unstructured":"Shi FD, Takeda K, Akira S, Sarvetnick N, Ljunggren HG (2000) IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-\u03b3 by NK cells. J Immunol 165:3099\u20133104","journal-title":"J Immunol"},{"key":"8553_CR61","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/79792","volume":"1","author":"FD Shi","year":"2000","unstructured":"Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG (2000) Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol 1:245\u2013251","journal-title":"Nat Immunol"},{"key":"8553_CR62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0065-2776(08)60664-1","volume":"47","author":"G Trinchieri","year":"1989","unstructured":"Trinchieri G (1989) Biology of natural killer cells. Adv Immunol 47:187\u2013376","journal-title":"Adv Immunol"},{"key":"8553_CR63","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.4049\/jimmunol.176.9.5247","volume":"176","author":"R Liu","year":"2006","unstructured":"Liu R, Van Kaer L, La Cava A, Price M, Campagnolo DI, Collins M, Young DA, Vollmer TL, Shi FD (2006) Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol 176:5247\u20135254","journal-title":"J Immunol"},{"key":"8553_CR64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1074-7613(02)00295-9","volume":"16","author":"MT Kasaian","year":"2002","unstructured":"Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ (2002) IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16:559\u2013569","journal-title":"Immunity"},{"key":"8553_CR65","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.4049\/jimmunol.174.5.2696","volume":"174","author":"TL Vollmer","year":"2005","unstructured":"Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, Shi FD (2005) Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 174:2696\u20132701","journal-title":"J Immunol"},{"key":"8553_CR66","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1182\/blood-2002-09-2876","volume":"101","author":"TA Fehniger","year":"2003","unstructured":"Fehniger TA, Cooper MA, Nuovo GJ, Cella M, Facchetti F, Colonna M, Caligiuri MA (2003) CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 101:3052\u20133057","journal-title":"Blood"},{"key":"8553_CR67","doi-asserted-by":"crossref","first-page":"16606","DOI":"10.1073\/pnas.0407522101","volume":"101","author":"G Ferlazzo","year":"2004","unstructured":"Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C (2004) Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci U S A 101:16606\u201316611","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8553_CR68","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.4049\/jimmunol.173.6.3716","volume":"173","author":"A Zingoni","year":"2004","unstructured":"Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL (2004) Cross-talk between activated human NK cells and CD4+ T cells via OX40\u2013OX40 ligand interactions. J Immunol 173:3716\u20133724","journal-title":"J Immunol"},{"key":"8553_CR69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0022-510X(89)90222-0","volume":"94","author":"Z Vranes","year":"1989","unstructured":"Vranes Z, Poljakovic Z, Marusic M (1989) Natural killer cell number and activity in multiple sclerosis. J Neurol Sci 94:115\u2013123","journal-title":"J Neurol Sci"},{"key":"8553_CR70","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1096\/fj.05-3832fje","volume":"19","author":"C Infante-Duarte","year":"2005","unstructured":"Infante-Duarte C, Weber A, Kratzschmar J, Prozorovski T, Pikol S, Hamann I, Bellmann-Strobl J, Aktas O, Dorr J, Wuerfel J, Sturzebecher CS, Zipp F (2005) Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients. FASEB J 19:1902\u20131904","journal-title":"FASEB J"},{"key":"8553_CR71","first-page":"94","volume":"15","author":"DS Schippling","year":"2008","unstructured":"Schippling DS, Martin R (2008) Spotlight on anti-CD25: daclizumab in MS. Int MS J 15:94\u201398","journal-title":"Int MS J"},{"key":"8553_CR72","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1073\/pnas.0601335103","volume":"103","author":"B Bielekova","year":"2006","unstructured":"Bielekova B, Catalfamo M, Reichert-Scrivner S, Packer A, Cerna M, Waldmann TA, McFarland H, Henkart PA, Martin R (2006) Regulatory CD56z(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A 103:5941\u20135946","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8553_CR73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","volume":"17","author":"CA Biron","year":"1999","unstructured":"Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP (1999) Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17:189\u2013220","journal-title":"Annu Rev Immunol"},{"key":"8553_CR74","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1002\/1521-4141(2001010)31:10<3048::AID-IMMU3048>3.0.CO;2-1","volume":"31","author":"HC Su","year":"2001","unstructured":"Su HC, Nguyen KB, Salazar-Mather TP, Ruzek MC, Dalod MY, Biron CA (2001) NK cell functions restrain T cell responses during viral infections. Eur J Immunol 31:3048\u20133055","journal-title":"Eur J Immunol"},{"key":"8553_CR75","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1073\/pnas.80.8.2346","volume":"80","author":"RS Fujinami","year":"1983","unstructured":"Fujinami RS, Oldstone MB, Wroblewska Z, Frankel ME, Koprowski H (1983) Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proc Natl Acad Sci U S A 80:2346\u20132350","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8553_CR76","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/heart.83.6.696","volume":"83","author":"Y Li","year":"2000","unstructured":"Li Y, Peng T, Yang Y, Niu C, Archard LC, Zhang H (2000) High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. Heart 83:696\u2013701","journal-title":"Heart"},{"key":"8553_CR77","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.19.1.80-94.2006","volume":"19","author":"RS Fujinami","year":"2006","unstructured":"Fujinami RS, von Herrath MG, Christen U, Whitton JL (2006) Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev 19:80\u201394","journal-title":"Clin Microbiol Rev"},{"key":"8553_CR78","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00867354","volume":"240","author":"O Andersen","year":"1993","unstructured":"Andersen O, Lygner PE, Bergstrom T, Andersson M, Vahlne A (1993) Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study. J Neurol 240:417\u2013422","journal-title":"J Neurol"},{"key":"8553_CR79","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/jnnp.64.6.736","volume":"64","author":"S Edwards","year":"1998","unstructured":"Edwards S, Zvartau M, Clarke H, Irving W, Blumhardt LD (1998) Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. J Neurol Neurosurg Psychiatry 64:736\u2013741","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"8553_CR80","unstructured":"Johnson RT (1998) Chronic inflammatory and demyelinating diseases. In: Viral infections of the nervous system. 2nd Ed. Lippincott-Raven, Philadelphia, pp. 227\u2013263"},{"key":"8553_CR81","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.1693015","volume":"248","author":"KW Wucherpfennig","year":"1990","unstructured":"Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA (1990) Shared human T cell receptor Vb usage to immunodominant regions of myelin basic protein. Science 248:1016\u20131019","journal-title":"Science"},{"key":"8553_CR82","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/08916930500484799","volume":"39","author":"L McCoy","year":"2006","unstructured":"McCoy L, Tsunoda I, Fujinami RS (2006) Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity 39:9\u201319","journal-title":"Autoimmunity"},{"key":"8553_CR83","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.it.2006.09.006","volume":"27","author":"SC Bangs","year":"2006","unstructured":"Bangs SC, McMichael AJ, Xu XN (2006) Bystander T cell activation\u2014implications for HIV infection and other diseases. Trends Immunol 27:518\u2013524","journal-title":"Trends Immunol"},{"key":"8553_CR84","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/smim.1993.1029","volume":"5","author":"BE Bierer","year":"1993","unstructured":"Bierer BE, Hahn WC (1993) T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2. Semin Immunol 5:249\u2013261","journal-title":"Semin Immunol"},{"key":"8553_CR85","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1084\/jem.180.3.1159","volume":"180","author":"D Unutmaz","year":"1994","unstructured":"Unutmaz D, Pilri P, Abrignani S (1994) Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 180:1159\u20131164","journal-title":"J Exp Med"},{"key":"8553_CR86","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.4049\/jimmunol.162.9.5609","volume":"162","author":"A Mathew","year":"1999","unstructured":"Mathew A, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL (1999) Impaired T cell proliferation in acute dengue infection. J Immunol 162:5609\u20135615","journal-title":"J Immunol"},{"key":"8553_CR87","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.4049\/jimmunol.168.11.5959","volume":"168","author":"I Zivna","year":"2002","unstructured":"Zivna I, Green S, Vaughn DW, Kalayanarooj S, Stephens HA, Chandanayingyong D, Nisalak A, Ennis FA, Rothman AL (2002) T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity. J Immunol 168:5959\u20135965","journal-title":"J Immunol"},{"key":"8553_CR88","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1128\/IAI.02046-05","volume":"74","author":"CA Rowland","year":"2006","unstructured":"Rowland CA, Lertmemongkolchai G, Bancroft A, Haque A, Lever MS, Griffin KF, Jackson MC, Nelson M, O\u2019Garra A, Grencis R, Bancroft GJ, Lukaszewski RA (2006) Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei. Infect Immun 74:5333\u20135340","journal-title":"Infect Immun"},{"key":"8553_CR89","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev.immunol.21.120601.141053","volume":"21","author":"DC Douek","year":"2003","unstructured":"Douek DC, Picker LJ, Koup RA (2003) T cell dynamics in HIV-1 infection. Annu Rev Immunol 21:265\u2013304","journal-title":"Annu Rev Immunol"},{"key":"8553_CR90","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI19799","volume":"112","author":"G Silvestri","year":"2003","unstructured":"Silvestri G, Feinberg MB (2003) Turnover of lymphocytes and conceptual paradigms in HIV infection. J Clin Invest 112:821\u2013824","journal-title":"J Clin Invest"},{"key":"8553_CR91","doi-asserted-by":"crossref","first-page":"R693","DOI":"10.1016\/S0960-9822(98)70438-5","volume":"8","author":"VA Fadok","year":"1998","unstructured":"Fadok VA, Henson PM (1998) Apoptosis: getting rid of the bodies. Curr Biol 8:R693\u2013R695","journal-title":"Curr Biol"},{"key":"8553_CR92","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.immuni.2007.11.014","volume":"27","author":"EY Chung","year":"2007","unstructured":"Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X (2007) Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity 27:952\u2013964","journal-title":"Immunity"},{"key":"8553_CR93","doi-asserted-by":"crossref","first-page":"880","DOI":"10.4049\/jimmunol.172.2.880","volume":"172","author":"M Cvetanovic","year":"2004","unstructured":"Cvetanovic M, Ucker DS (2004) Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition. J Immunol 172:880\u2013889","journal-title":"J Immunol"},{"key":"8553_CR94","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1126\/science.1094359","volume":"304","author":"R Hanayama","year":"2004","unstructured":"Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304:1147\u20131150","journal-title":"Science"},{"key":"8553_CR95","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2353\/ajpath.2007.070135","volume":"171","author":"LP Erwig","year":"2007","unstructured":"Erwig LP, Henson PM (2007) Immunological consequences of apoptotic cell phagocytosis. Am J Pathol 171:2\u20138","journal-title":"Am J Pathol"},{"key":"8553_CR96","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cell.2010.02.014","volume":"140","author":"S Nagata","year":"2010","unstructured":"Nagata S, Hanayama R, Kawane K (2010) Autoimmunity and the clearance of dead cells. Cell 140:619\u2013630","journal-title":"Cell"},{"key":"8553_CR97","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11926-004-0016-1","volume":"6","author":"US Gaipl","year":"2004","unstructured":"Gaipl US, Franz S, Voll RE, Sheriff A, Kalden JR, Herrmann M (2004) Defects in the disposal of dying cells lead to autoimmunity. Curr Rheumatol Rep 6:401\u2013407","journal-title":"Curr Rheumatol Rep"},{"key":"8553_CR98","first-page":"223","volume":"32","author":"MJ Arends","year":"1991","unstructured":"Arends MJ, Wyllie AH (1991) Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp Pathol 32:223\u2013254","journal-title":"Exp Pathol"},{"key":"8553_CR99","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/emboj\/17.6.1675","volume":"17","author":"C Scaffidi","year":"1998","unstructured":"Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME (1998) Two CD95 (APO-1\/Fas) signaling pathways. EMBO J 17:1675\u20131687","journal-title":"EMBO J"},{"key":"8553_CR100","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/emboj\/16.10.2794","volume":"16","author":"JP Medema","year":"1997","unstructured":"Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16:2794\u20132804","journal-title":"EMBO J"},{"key":"8553_CR101","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)80430-4","volume":"91","author":"GS Salvesen","year":"1997","unstructured":"Salvesen GS, Dixit VM (1997) Caspases: intracellular signaling by proteolysis. Cell 91:443\u2013446","journal-title":"Cell"},{"key":"8553_CR102","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1155\/2009\/214216","volume":"2009","author":"UR Goonetilleke","year":"2009","unstructured":"Goonetilleke UR, Ward SA, Gordon SB (2009) Could proteomic research deliver the next generation of treatments for pneumococcal meningitis? Interdiscip Perspect Infect Dis 2009:214\u2013216","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"8553_CR103","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","volume":"281","author":"NA Thornberry","year":"1998","unstructured":"Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312\u20131316","journal-title":"Science"},{"key":"8553_CR104","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","volume":"91","author":"P Li","year":"1997","unstructured":"Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479\u2013489","journal-title":"Cell"},{"key":"8553_CR105","first-page":"1835","volume":"57","author":"Y Eguchi","year":"1997","unstructured":"Eguchi Y, Shimizu S, Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57:1835\u20131840","journal-title":"Cancer Res"},{"key":"8553_CR106","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0955-0674(95)80084-0","volume":"7","author":"F Melchior","year":"1995","unstructured":"Melchior F, Gerace L (1995) Mechanisms of nuclear protein import. Curr Opin Cell Biol 7:310\u2013318","journal-title":"Curr Opin Cell Biol"},{"key":"8553_CR107","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2443.1997.1010302.x","volume":"2","author":"N Yasuhara","year":"1997","unstructured":"Yasuhara N, Eguchi Y, Tachibana T, Imamoto N, Yoneda Y, Tsujimoto Y (1997) Essential role of active nuclear transport in apoptosis. Genes Cells 2:55\u201364","journal-title":"Genes Cells"},{"key":"8553_CR108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1376506","volume":"20","author":"WX Zong","year":"2006","unstructured":"Zong WX, Thompson CB (2006) Necrotic death as a cell fate. Genes Dev 20:1\u201315","journal-title":"Genes Dev"},{"key":"8553_CR109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4827(02)00027-7","volume":"283","author":"SY Proskuryakov","year":"2003","unstructured":"Proskuryakov SY, Konoplyannikov AG, Gabai VL (2003) Necrosis: a specific form of programmed cell death? Exp Cell Res 283:1\u201316","journal-title":"Exp Cell Res"},{"key":"8553_CR110","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1074\/jbc.M508135200","volume":"281","author":"Y Xu","year":"2006","unstructured":"Xu Y, Huang S, Liu ZG, Han J (2006) Poly(ADP-ribose) polymerase-1 signalling to mitochondria in necrotic cell death requires RIP1\/TRAF2-mediated JNK1 activation. J Biol Chem 281:8788\u20138795","journal-title":"J Biol Chem"},{"key":"8553_CR111","first-page":"110","volume":"86","author":"Y Chen","year":"2009","unstructured":"Chen Y (2009) Necrosis: an energy-dependent programmed cell death? UTMJ 86:110\u2013112","journal-title":"UTMJ"},{"key":"8553_CR112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","volume":"17","author":"TS Blackwell","year":"1997","unstructured":"Blackwell TS, Christman JW (1997) The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 17:3\u20139","journal-title":"Am J Respir Cell Mol Biol"},{"key":"8553_CR113","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1179\/096805100101532414","volume":"6","author":"G Zhang","year":"2000","unstructured":"Zhang G, Ghosh S (2000) Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J Endotoxin Res 6:453\u2013457","journal-title":"J Endotoxin Res"},{"key":"8553_CR114","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","volume":"10","author":"U Siebenlist","year":"1994","unstructured":"Siebenlist U, Franzoso G, Brown K (1994) Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol 10:405\u2013455","journal-title":"Annu Rev Cell Biol"},{"key":"8553_CR115","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","volume":"72","author":"G Gloire","year":"2006","unstructured":"Gloire G, Legrand-Poels S, Piette J (2006) NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72:1493\u20131505","journal-title":"Biochem Pharmacol"},{"key":"8553_CR116","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1476-9255-4-23","volume":"4","author":"E Jones","year":"2007","unstructured":"Jones E, Adcock IM, Ahmed BY, Punchard NA (2007) Modulation of LPS stimulated NF-kappaB mediated nitric oxide production by PKCepsilon and JAK2 in RAW macrophages. J Inflamm (Lond) 4:23","journal-title":"J Inflamm (Lond)"},{"key":"8553_CR117","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.immuni.2006.07.010","volume":"25","author":"T Enzler","year":"2006","unstructured":"Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M (2006) Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25:403\u2013415","journal-title":"Immunity"},{"key":"8553_CR118","doi-asserted-by":"crossref","first-page":"35478","DOI":"10.1074\/jbc.M005224200","volume":"275","author":"Y Wu","year":"2000","unstructured":"Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP (2000) Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. J Biol Chem 275:35478\u201335485","journal-title":"J Biol Chem"},{"key":"8553_CR119","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1084\/jem.20030495","volume":"198","author":"ZS Rahman","year":"2003","unstructured":"Rahman ZS, Rao SP, Kalled SL, Manser T (2003) Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med 198:1157\u20131169","journal-title":"J Exp Med"},{"key":"8553_CR120","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.it.2011.06.004","volume":"32","author":"Z Liu","year":"2011","unstructured":"Liu Z, Davidson A (2011) BAFF and selection of autoreactive B cells. Trends Immunol 32:388\u2013394","journal-title":"Trends Immunol"},{"key":"8553_CR121","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1097\/00003246-200201001-00003","volume":"30","author":"U Senftleben","year":"2002","unstructured":"Senftleben U, Karin M (2002) The IKK\/NF-kappa B pathway. Crit Care Med 30:S18\u2013S26","journal-title":"Crit Care Med"},{"key":"8553_CR122","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1084\/jem.189.11.1839","volume":"189","author":"ZW Li","year":"1999","unstructured":"Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189:1839\u20131845","journal-title":"J Exp Med"},{"key":"8553_CR123","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","volume":"3","author":"M Karin","year":"2002","unstructured":"Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3:221\u2013227","journal-title":"Nat Immunol"},{"key":"8553_CR124","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/smim.2000.0210","volume":"12","author":"M Karin","year":"2000","unstructured":"Karin M, Delhase M (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 12:85\u201398","journal-title":"Semin Immunol"},{"key":"8553_CR125","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1126\/science.1062677","volume":"293","author":"U Senftleben","year":"2001","unstructured":"Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M (2001) Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293:1495\u20131499","journal-title":"Science"},{"key":"8553_CR126","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","volume":"25","author":"G Bonizzi","year":"2004","unstructured":"Bonizzi G, Karin M (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25:280\u2013288","journal-title":"Trends Immunol"},{"key":"8553_CR127","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1172\/JCI26322","volume":"115","author":"JL Luo","year":"2005","unstructured":"Luo JL, Kamata H, Karin M (2005) IKK\/NF-kappaB signaling: balancing life and death\u2014a new approach to cancer therapy. J Clin Invest 115:2625\u20132632","journal-title":"J Clin Invest"},{"key":"8553_CR128","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","volume":"116","author":"NN Danial","year":"2004","unstructured":"Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205\u2013219","journal-title":"Cell"},{"key":"8553_CR129","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770\u2013776","journal-title":"Nature"},{"key":"8553_CR130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/376167a0","volume":"376","author":"AA Beg","year":"1995","unstructured":"Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167\u2013170","journal-title":"Nature"},{"key":"8553_CR131","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1073\/pnas.96.6.2994","volume":"96","author":"TS Doi","year":"1999","unstructured":"Doi TS, Marino MW, Takahashi T, Yoshida T, Sakakura T, Old LJ, Obata Y (1999) Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc Natl Acad Sci U S A 96:2994\u20132999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8553_CR132","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.1038\/sj.onc.1207230","volume":"22","author":"J Kucharczak","year":"2003","unstructured":"Kucharczak J, Simmons MJ, Fan Y, Gelinas C (2003) To be, or not to be: NF-kappaB is the answer\u2014role of Rel\/NF-kappaB in the regulation of apoptosis. Oncogene 22:8961\u20138982","journal-title":"Oncogene"},{"key":"8553_CR133","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1158\/0008-5472.CAN-03-3361","volume":"64","author":"Y Zhang","year":"2004","unstructured":"Zhang Y, Chen F (2004) Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK). Cancer Res 64:1902\u20131905","journal-title":"Cancer Res"},{"key":"8553_CR134","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.bcp.2006.07.003","volume":"72","author":"A Wullaert","year":"2006","unstructured":"Wullaert A, Heyninck K, Beyaert R (2006) Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol 72:1090\u20131101","journal-title":"Biochem Pharmacol"},{"key":"8553_CR135","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1093\/emboj\/cdg379","volume":"22","author":"S Sakon","year":"2003","unstructured":"Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Piao JH, Yagita H, Okumura K, Doi T, Nakano H (2003) NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22:3898\u20133909","journal-title":"EMBO J"},{"key":"8553_CR136","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0213-9626(09)70025-3","volume":"28","author":"C Gonzales-Garcia","year":"2009","unstructured":"Gonzales-Garcia C, Martin-Saavedra FM, Ballestar A, Ballestar S (2009) The Th17 lineage: answers to some immunological questions. Inmunologia 28:32\u201345","journal-title":"Inmunologia"},{"key":"8553_CR137","doi-asserted-by":"crossref","first-page":"819467","DOI":"10.1155\/2012\/819467","volume":"2012","author":"JC Waite","year":"2012","unstructured":"Waite JC, Skokos D (2012) Th17 response and inflammatory autoimmune diseases. Int J Inflamm 2012:819467","journal-title":"Int J Inflamm"},{"key":"8553_CR138","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","volume":"8","author":"L Zhou","year":"2007","unstructured":"Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8:967\u2013974","journal-title":"Nat Immunol"},{"key":"8553_CR139","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/BOR.0b013e3282fa13b4","volume":"20","author":"A Finckh","year":"2008","unstructured":"Finckh A, Gabay C (2008) At the horizon of innovative therapy in rheumatology: new biologic agents. Curr Opin Rheumatol 20:269\u2013275","journal-title":"Curr Opin Rheumatol"},{"key":"8553_CR140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3083.2011.02536.x","volume":"74","author":"F Jadidi-Niaragh","year":"2011","unstructured":"Jadidi-Niaragh F, Mirshafiey A (2011) Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol 74:1\u201313","journal-title":"Scand J Immunol"},{"key":"8553_CR141","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.179.3.1423","volume":"179","author":"I Kryczek","year":"2007","unstructured":"Kryczek I, Wei S, Vatan L, Escara-Wilke J, Szeliga W, Keller ET, Zou W (2007) Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression. J Immunol 179:1423\u20131426","journal-title":"J Immunol"},{"key":"8553_CR142","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/art.27242","volume":"62","author":"LAB Joosten","year":"2010","unstructured":"Joosten LAB (2010) Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammation. Arthr Rheumatism 62:320\u2013322","journal-title":"Arthr Rheumatism"},{"key":"8553_CR143","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.clim.2008.12.008","volume":"131","author":"F Deknuydt","year":"2009","unstructured":"Deknuydt F, Bioley G, Valmon D, Ayyoub M (2009) IL-1\u03b2 and IL-2 convert human Treg into TH17 cells. Clin Immunol 131:298\u2013307","journal-title":"Clin Immunol"},{"key":"8553_CR144","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.micinf.2009.04.002","volume":"11","author":"SF Ziegler","year":"2009","unstructured":"Ziegler SF, Buckner JH (2009) FOXP3 and the regulation of Treg\/Th17 differentiation. Microbes Infect 11:594\u2013598","journal-title":"Microbes Infect"},{"key":"8553_CR145","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","volume":"13","author":"H Kebir","year":"2007","unstructured":"Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A (2007) Human TH17 lymphocytes promote blood\u2013brain barrier disruption and central nervous system inflammation. Nat Med 13:1173\u20131175","journal-title":"Nat Med"},{"key":"8553_CR146","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1523\/JNEUROSCI.2674-08.2008","volume":"28","author":"BW McColl","year":"2008","unstructured":"McColl BW, Rothwell NJ, Allan SM (2008) Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 28:9451\u20139462","journal-title":"J Neurosci"},{"key":"8553_CR147","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1155\/S0962935192000292","volume":"1","author":"MK Sharief","year":"1992","unstructured":"Sharief MK, Ciardi M, Thompson EJ, Sorice F, Rossi F, Vullo V, Cirelli A (1992) Tumour necrosis factor-alpha mediates blood\u2013brain barrier damage in HIV-1 infection of the central nervous system. Mediators Inflamm 1:191\u2013196","journal-title":"Mediators Inflamm"},{"key":"8553_CR148","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","volume":"286","author":"TY Ma","year":"2004","unstructured":"Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, Said HM (2004) TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol 286:G367\u2013G376","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"8553_CR149","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","volume":"178","author":"RM Al-Sadi","year":"2007","unstructured":"Al-Sadi RM, Ma TY (2007) IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol 178:4641\u20134649","journal-title":"J Immunol"},{"key":"8553_CR150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1743-7075-7-79","volume":"7","author":"SE Lakhan","year":"2010","unstructured":"Lakhan SE, Kirchgessner A (2010) Gut inflammation in chronic fatigue syndrome. Nutr Metab (Lond) 7:79","journal-title":"Nutr Metab (Lond)"},{"key":"8553_CR151","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1128\/JVI.00768-08","volume":"82","author":"H Wang","year":"2008","unstructured":"Wang H, Sun J, Goldstein H (2008) Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood\u2013brain barrier into the brain and the in vivo sensitivity of the blood\u2013brain barrier to disruption by lipopolysaccharide. J Virol 82:7591\u20137600","journal-title":"J Virol"},{"key":"8553_CR152","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1750-1326-6-84","volume":"6","author":"B Xing","year":"2011","unstructured":"Xing B, Bachstetter AD, Eldik LJ (2011) Microglial p38\u03b1 MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNF\u03b1. Mol Neurodegener 6:84","journal-title":"Mol Neurodegener"},{"key":"8553_CR153","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/157339507780655496","volume":"3","author":"VS Chauhan","year":"2007","unstructured":"Chauhan VS, Marriott I (2007) Bacterial infections of the central nervous system: a critical role for resident glial cells in the initiation and progression of inflammation. Curr Immunol 3:133\u2013143","journal-title":"Curr Immunol"},{"key":"8553_CR154","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1128\/CMR.17.4.942-964.2004","volume":"17","author":"RB Rock","year":"2004","unstructured":"Rock RB, Gekker G, Hu S, Sheng WS, Cheeran M, Lokensgard JR, Peterson PK (2004) Role of microglia in central nervous system infections. Clin Microbiol Rev 17:942\u2013964","journal-title":"Clin Microbiol Rev"},{"key":"8553_CR155","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1128\/IAI.00967-06","volume":"74","author":"RK Yu","year":"2006","unstructured":"Yu RK, Usuki S, Ariga T (2006) Ganglioside molecular mimicry and its pathological roles in Guillain\u2013Barr\u00e9 syndrome and related diseases. Infect Immun 74:6517\u20136527","journal-title":"Infect Immun"},{"key":"8553_CR156","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1128\/IAI.70.9.5081-5085.2002","volume":"70","author":"CW Ang","year":"2002","unstructured":"Ang CW, Noordzij PG, de Klerk MA, Endtz HP, van Doorn PA, Laman JD (2002) Ganglioside mimicry of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity in rabbits. Infect Immun 70:5081\u20135085","journal-title":"Infect Immun"},{"key":"8553_CR157","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1046\/j.1471-4159.1999.0720652.x","volume":"72","author":"YS Wang","year":"1999","unstructured":"Wang YS, White TD (1999) The bacterial endotoxin lipopolysaccharide causes rapid inappropriate excitation in rat cortex. J Neurochem 72:652\u2013660","journal-title":"J Neurochem"},{"key":"8553_CR158","first-page":"6","volume":"2","author":"G Sherbet","year":"2009","unstructured":"Sherbet G (2009) Bacterial infections and the pathogenesis of autoimmune conditions. BJMP 2:6\u201313","journal-title":"BJMP"},{"key":"8553_CR159","first-page":"487450","volume":"2011","author":"KU Tufekci","year":"2011","unstructured":"Tufekci KU, Genc S, Genc K (2011) The endotoxin-induced neuroinflammation model of Parkinson\u2019s disease. Parkinsons Dis 2011:487450","journal-title":"Parkinsons Dis"},{"key":"8553_CR160","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/BF02100148","volume":"41","author":"B Yacyshyn","year":"1996","unstructured":"Yacyshyn B, Meddings J, Sadowski D, Bowen-Yacyshyn MB (1996) Multiple sclerosis patients have peripheral blood CD45RO + B cells and increased intestinal permeability. Dig Dis Sci 41:2493\u20132498","journal-title":"Dig Dis Sci"},{"key":"8553_CR161","doi-asserted-by":"crossref","first-page":"e28032","DOI":"10.1371\/journal.pone.0028032","volume":"6","author":"CB Forsyth","year":"2011","unstructured":"Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, Estes JD, Dodiya HB, Keshavarzian A (2011) Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson\u2019s disease. PLoS One 6:e28032","journal-title":"PLoS One"},{"key":"8553_CR162","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0891-5849(96)00586-2","volume":"23","author":"T Grune","year":"1997","unstructured":"Grune T, Michel P, Sitte N, Eggert W, Albrecht-Nebe H, Esterbauer H, Siems WG (1997) Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic Biol Med 23:357\u2013360","journal-title":"Free Radic Biol Med"},{"key":"8553_CR163","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.autrev.2008.04.019","volume":"7","author":"BT Kurien","year":"2008","unstructured":"Kurien BT, Scofield RH (2008) Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 7:567\u2013573","journal-title":"Autoimmun Rev"},{"key":"8553_CR164","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-4274(97)00032-5","volume":"92","author":"MF Khan","year":"1997","unstructured":"Khan MF, Wu X, Kaphalia BS, Boor PJ, Ansari GA (1997) Acute hematopoietic toxicity of aniline in rats. Toxicol Lett 92:31\u201337","journal-title":"Toxicol Lett"},{"key":"8553_CR165","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.179.2.651","volume":"179","author":"JB Weinberg","year":"1994","unstructured":"Weinberg JB, Granger DL, Pisetsky DS, Seldin MF, Misukonis MA, Mason SN, Pippen AM, Ruiz P, Wood ER, Gilkeson GS (1994) The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr\/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-l-arginine. J Exp Med 179:651\u2013660","journal-title":"J Exp Med"},{"key":"8553_CR166","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-3083.2006.01794.x","volume":"64","author":"F Khan","year":"2006","unstructured":"Khan F, Siddiqui AA, Ali R (2006) Measurement and significance of 3-nitrotyrosine in systemic lupus erythematosus. Scand J Immunol 64:507\u2013514","journal-title":"Scand J Immunol"},{"key":"8553_CR167","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5483\/BMBRep.2006.39.2.189","volume":"39","author":"F Khan","year":"2006","unstructured":"Khan F, Ali R (2006) Antibodies against nitric oxide damaged poly l-tyrosine and 3-nitrotyrosine levels in systemic lupus erythematosus. J Biochem Mol Biol 39:189\u2013196","journal-title":"J Biochem Mol Biol"},{"key":"8553_CR168","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.freeradbiomed.2006.05.020","volume":"41","author":"BT Kurien","year":"2006","unstructured":"Kurien BT, Hensley K, Bachmann M, Scofield RH (2006) Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 41:549\u2013556","journal-title":"Free Radic Biol Med"},{"key":"8553_CR169","first-page":"1096","volume":"261","author":"B Christensen","year":"1992","unstructured":"Christensen B, Refsum H, Garras A, Ueland PM (1992) Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates. J Pharmacol Exp Ther 261:1096\u20131105","journal-title":"J Pharmacol Exp Ther"},{"key":"8553_CR170","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1373\/49.8.1292","volume":"49","author":"R Castro","year":"2003","unstructured":"Castro R, Rivera I, Struys EA, Jansen EE, Ravasco P, Camilo ME, Blom HJ, Jakobs C, Tavares de Almeida I (2003) Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem 49:1292\u20131296","journal-title":"Clin Chem"},{"key":"8553_CR171","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.exger.2009.12.008","volume":"45","author":"Y Li","year":"2010","unstructured":"Li Y, Liu Y, Strickland FM, Richardson B (2010) Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes. Exp Gerontol 45:312\u2013322","journal-title":"Exp Gerontol"},{"key":"8553_CR172","first-page":"931018","volume":"2010","author":"M Zhao","year":"2010","unstructured":"Zhao M, Tang J, Gao F, Wu X, Liang Y, Yin H, Lu Q (2010) Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus. J Biomed Biotechnol 2010:931018","journal-title":"J Biomed Biotechnol"},{"key":"8553_CR173","volume-title":"Gene discovery for disease models","author":"X Xu","year":"2012","unstructured":"Xu X, Yang P, Shu Z, Bai Y, Wang CY (2012) DNA methylation in the pathogenesis of autoimmunity. In: Gu W, Wang Y (eds) Gene discovery for disease models. Wiley, Hoboken"},{"key":"8553_CR174","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1002\/art.25018","volume":"60","author":"E Karouzakis","year":"2009","unstructured":"Karouzakis E, Gay RE, Michel BA, Gay S, Neidhart M (2009) DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 60:3613\u20133622","journal-title":"Arthritis Rheum"},{"key":"8553_CR175","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0022-2143(96)90008-6","volume":"128","author":"YI Kim","year":"1996","unstructured":"Kim YI, Logan JW, Mason JB, Roubenoff R (1996) DNA hypomethylation in inflammatory arthritis: reversal with methotrexate. J Lab Clin Med 128:165\u2013172","journal-title":"J Lab Clin Med"},{"key":"8553_CR176","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/art.1780331109","volume":"33","author":"B Richardson","year":"1990","unstructured":"Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M (1990) Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 33:1665\u20131673","journal-title":"Arthritis Rheum"},{"key":"8553_CR177","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0198-8859(86)90304-6","volume":"17","author":"B Richardson","year":"1986","unstructured":"Richardson B (1986) Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells. Hum Immunol 17:456\u2013470","journal-title":"Hum Immunol"},{"key":"8553_CR178","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1073\/pnas.092259799","volume":"99","author":"B Beltran","year":"2002","unstructured":"Beltran B, Quintero M, Garcia-Zaragoza E, O\u2019Connor E, Esplugues JV, Moncada S (2002) Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling. Proc Natl Acad Sci U S A 99:8892\u20138897","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8553_CR179","first-page":"93","volume":"184","author":"A Perl","year":"2010","unstructured":"Perl A, Telarico T, Singh R, Fernandez D (2010) Activation of the nitric oxide\u2013mitochondrial hyperpolarization\u2013mTOR\u2013Rab4 signaling pathway precedes disease development in lupus T cells. J Immunol 184:93.36","journal-title":"J Immunol"},{"key":"8553_CR180","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3045","volume":"12","author":"G Nagy","year":"2010","unstructured":"Nagy G, Koncz A, Telarico T, Fernandez D, Ersek B, Buzas E, Perl A (2010) Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 12:210","journal-title":"Arthritis Res Ther"},{"key":"8553_CR181","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","volume":"18","author":"N Hay","year":"2004","unstructured":"Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926\u20131945","journal-title":"Genes Dev"},{"key":"8553_CR182","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.2174\/138161211798357809","volume":"17","author":"M Pierdominici","year":"2011","unstructured":"Pierdominici M, Vacirca D, Delunardo F, Ortona E (2011) mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases. Curr Pharm Des 17:3888\u20133897","journal-title":"Curr Pharm Des"},{"key":"8553_CR183","doi-asserted-by":"crossref","first-page":"568343","DOI":"10.1155\/2010\/568343","volume":"2010","author":"P Fernandez-Riejos","year":"2010","unstructured":"Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, Sanchez-Margalet V (2010) Role of leptin in the activation of immune cells. Mediators Inflamm 2010:568343","journal-title":"Mediators Inflamm"},{"key":"8553_CR184","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2567.2009.03125.x","volume":"127","author":"GM Delgoffe","year":"2009","unstructured":"Delgoffe GM, Powell JD (2009) mTOR: taking cues from the immune microenvironment. Immunology 127:459\u2013465","journal-title":"Immunology"},{"key":"8553_CR185","doi-asserted-by":"crossref","first-page":"e35572","DOI":"10.1371\/journal.pone.0035572","volume":"7","author":"E Yurchenko","year":"2012","unstructured":"Yurchenko E, Shio MT, Huang TC, Da Silva Martins M, Szyf M, Levings MK, Oliver M, Piccirillo CA (2012) Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1\/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS ONE 7:e35572","journal-title":"PLoS ONE"},{"key":"8553_CR186","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.20071477","volume":"205","author":"S Haxhinasto","year":"2008","unstructured":"Haxhinasto S, Mathis D, Benoist C (2008) The AKT-mTOR axis regulates de novo differentiation of CD4 + Foxp3+ cells. J Exp Med 205:565\u2013574","journal-title":"J Exp Med"},{"key":"8553_CR187","first-page":"173","volume":"9","author":"D Fernandez","year":"2010","unstructured":"Fernandez D, Perl A (2010) mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus? Discov Med 9:173\u2013178","journal-title":"Discov Med"},{"key":"8553_CR188","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.4049\/jimmunol.1200935","volume":"189","author":"C Procaccini","year":"2012","unstructured":"Procaccini C, De Rosa V, Galgani M, Carbone F, Cassano S, Greco D, Qian K, Auvinen P, Cal\u00ec G, Stallone G, Formisano L, La Cava A, Matarese G (2012) Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J Immunol 189:2941\u20132953","journal-title":"J Immunol"},{"key":"8553_CR189","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1399-0039.2007.00886.x","volume":"70","author":"G Matarese","year":"2007","unstructured":"Matarese G, Leiter EH, La Cava A (2007) Leptin in autoimmunity: many questions, some answers. Tissue Antigens 70:87\u201395","journal-title":"Tissue Antigens"},{"key":"8553_CR190","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1096\/fj.01-0431rev","volume":"15","author":"R Faggioni","year":"2001","unstructured":"Faggioni R, Feingold KR, Grunfeld C (2001) Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 15:2565\u20132571","journal-title":"FASEB J"},{"key":"8553_CR191","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1038\/oby.2003.209","volume":"11","author":"J Bettowski","year":"2003","unstructured":"Bettowski J, Wojcicka G, Jamroz A (2003) Stimulatory effect of leptin on nitric oxide production is impaired in dietary-induced obesity. Obes Res 11:1571\u20131580","journal-title":"Obes Res"},{"key":"8553_CR192","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1096\/fasebj.12.1.57","volume":"12","author":"S Loffreda","year":"1998","unstructured":"Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM (1998) Leptin regulates proinflammatory immune responses. FASEB J 12:57\u201365","journal-title":"FASEB J"},{"key":"8553_CR193","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/j.1538-7836.2007.02578.x","volume":"5","author":"E Napoleone","year":"2007","unstructured":"Napoleone E, DI Santo A, Amore C, Baccante G, di Febbo C, Porreca E, de Gaetano G, Donati MB, Lorenzet R (2007) Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk? J Thromb Haemost 5:1462\u20131468","journal-title":"J Thromb Haemost"},{"key":"8553_CR194","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/cimm.1999.1594","volume":"199","author":"C Martin-Romero","year":"2000","unstructured":"Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V (2000) Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 199:15\u201324","journal-title":"Cell Immunol"},{"key":"8553_CR195","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2249.2007.03563.x","volume":"151","author":"P Fernandez-Riejos","year":"2008","unstructured":"Fernandez-Riejos P, Goberna R, Sanchez-Margalet V (2008) Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase. Clin Exp Immunol 151:505\u2013518","journal-title":"Clin Exp Immunol"},{"key":"8553_CR196","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-2249.2002.01900.x","volume":"129","author":"V Sanchez-Margalet","year":"2002","unstructured":"Sanchez-Margalet V, Martin-Romero C, Gonzalez-Yanes C, Goberna R, Rodriguez-Bano J, Muniain MA (2002) Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clin Exp Immunol 129:119\u2013124","journal-title":"Clin Exp Immunol"},{"key":"8553_CR197","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.4049\/jimmunol.167.8.4593","volume":"167","author":"H Zarkesh-Esfahani","year":"2001","unstructured":"Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, Weetman AP, Strasburger CJ, Ross RJ (2001) High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 167:4593\u20134599","journal-title":"J Immunol"},{"key":"8553_CR198","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbrc.2009.04.121","volume":"384","author":"N Kiguchi","year":"2009","unstructured":"Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S (2009) Leptin enhances CC-chemokine ligand expression in cultured murine macrophage. Biochem Biophys Res Commun 384:311\u2013315","journal-title":"Biochem Biophys Res Commun"},{"key":"8553_CR199","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/eji.200636866","volume":"37","author":"CK Wong","year":"2007","unstructured":"Wong CK, Cheung PF, Lam CW (2007) Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur J Immunol 37:2337\u20132348","journal-title":"Eur J Immunol"},{"key":"8553_CR200","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.febslet.2009.02.029","volume":"583","author":"B Mattioli","year":"2009","unstructured":"Mattioli B, Giordani L, Quaranta MG, Viora M (2009) Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K\u2013Akt signaling pathway. FEBS Lett 583:1102\u20131106","journal-title":"FEBS Lett"},{"key":"8553_CR201","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.coi.2008.03.003","volume":"20","author":"FE Lund","year":"2008","unstructured":"Lund FE (2008) Cytokine-producing B lymphocytes\u2014key regulators of immunity. Curr Opin Immunol 20:332\u2013338","journal-title":"Curr Opin Immunol"},{"key":"8553_CR202","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0167-5699(97)01080-3","volume":"18","author":"V Pistoia","year":"1997","unstructured":"Pistoia V (1997) Production of cytokines by human B cells in health and disease. Immunol Today 18:343\u2013350","journal-title":"Immunol Today"},{"key":"8553_CR203","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.176.2.705","volume":"176","author":"A Mizoguchi","year":"2006","unstructured":"Mizoguchi A, Bhan AK (2006) A case for regulatory B cells. J Immunol 176:705\u2013710","journal-title":"J Immunol"},{"key":"8553_CR204","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nri2729","volume":"10","author":"FE Lund","year":"2010","unstructured":"Lund FE, Randall TD (2010) Effector and regulatory B cells: modulators of CD4(+) T cell immunity. Nat Rev Immunol 10:236\u2013247","journal-title":"Nat Rev Immunol"},{"key":"8553_CR205","doi-asserted-by":"crossref","first-page":"e19366","DOI":"10.1371\/journal.pone.0019366","volume":"6","author":"MG de Goer de Herve","year":"2011","unstructured":"de Goer de Herve MG, Durali D, Dembele B, Giuliani M, Tran TA, Azzarone B, Eid P, Tardieu M, Delfraissy JF, Taoufik Y (2011) Interferon-alpha triggers B cell effector 1 (Be1) commitment. PLoS One 6:e19366","journal-title":"PLoS One"},{"key":"8553_CR206","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.2741\/2254","volume":"12","author":"I Sanz","year":"2007","unstructured":"Sanz I, Anolik JH, Looney RJ (2007) B cell depletion therapy in autoimmune diseases. Front Biosci 12:2546\u20132567","journal-title":"Front Biosci"},{"key":"8553_CR207","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/j.seminhematol.2010.01.010","volume":"47","author":"R Stasi","year":"2010","unstructured":"Stasi R (2010) Rituximab in autoimmune hematologic diseases: not just a matter of B cells. Semin Hematol 47:170\u2013179","journal-title":"Semin Hematol"},{"key":"8553_CR208","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.4049\/jimmunol.174.11.6781","volume":"174","author":"DP Harris","year":"2005","unstructured":"Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE (2005) Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174:6781\u20136790","journal-title":"J Immunol"},{"key":"8553_CR209","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.4049\/jimmunol.175.11.7103","volume":"175","author":"DP Harris","year":"2005","unstructured":"Harris DP, Goodrich S, Mohrs K, Mohrs M, Lund FE (2005) Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol 175:7103\u20137107","journal-title":"J Immunol"},{"key":"8553_CR210","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/82717","volume":"1","author":"DP Harris","year":"2000","unstructured":"Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, Johnson LL, Swain SL, Lund FE (2000) Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol 1:475\u2013482","journal-title":"Nat Immunol"},{"key":"8553_CR211","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.4049\/jimmunol.172.6.3422","volume":"172","author":"ME Duddy","year":"2004","unstructured":"Duddy ME, Alter A, Bar-Or A (2004) Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol 172:3422\u20133427","journal-title":"J Immunol"},{"key":"8553_CR212","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","volume":"32","author":"PA Blair","year":"2010","unstructured":"Blair PA, Norena LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C (2010) CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 32:129\u2013140","journal-title":"Immunity"},{"key":"8553_CR213","first-page":"A59","volume":"70","author":"JO Pers","year":"2011","unstructured":"Pers JO, Lemoine S, Morva A, Saraux A, Jamin C, Youinou P (2011) Impaired regulatory capacities of B lymphocytes in systemic lupus erytematosus. Ann Rheum Dis 70:A59","journal-title":"Ann Rheum Dis"},{"key":"8553_CR214","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.4049\/jimmunol.180.12.8153","volume":"180","author":"MJ Gros","year":"2008","unstructured":"Gros MJ, Naquet P, Guinamard RR (2008) Intrinsic TGF-beta 1 regulation of B cells. J Immunol 180:8153\u20138158","journal-title":"J Immunol"},{"key":"8553_CR215","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.immuni.2008.03.017","volume":"28","author":"K Yanaba","year":"2008","unstructured":"Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF (2008) A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28:639\u2013650","journal-title":"Immunity"},{"key":"8553_CR216","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.it.2007.10.004","volume":"29","author":"C Mauri","year":"2008","unstructured":"Mauri C, Ehrenstein MR (2008) The \u2018short\u2019 history of regulatory B cells. Trends Immunol 29:34\u201340","journal-title":"Trends Immunol"},{"key":"8553_CR217","doi-asserted-by":"crossref","first-page":"e26358","DOI":"10.1371\/journal.pone.0026358","volume":"6","author":"O Fluge","year":"2011","unstructured":"Fluge O, Bruland O, Risa K, Storstein A, Kristoffersen EK, Sapkota D, N\u00e6ss H, Dahl O, Nyland H, Mella O (2011) Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS ONE 6:e26358","journal-title":"PLoS ONE"},{"key":"8553_CR218","doi-asserted-by":"crossref","first-page":"iv55","DOI":"10.1136\/ard.2005.042648","volume":"64","author":"R Eisenberg","year":"2005","unstructured":"Eisenberg R (2005) Update on rituximab. Ann Rheum Dis 64:iv55\u2013iv57","journal-title":"Ann Rheum Dis"},{"key":"8553_CR219","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.intimp.2008.10.004","volume":"9","author":"HM Gurcan","year":"2009","unstructured":"Gurcan HM, Keskin DB, Stern JN, Nitzberg MA, Shekhani H, Ahmed AR (2009) A review of the current use of rituximab in autoimmune diseases. Int Immunopharmacol 9:10\u201325","journal-title":"Int Immunopharmacol"},{"key":"8553_CR220","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1056\/NEJMoa032534","volume":"350","author":"JC Edwards","year":"2004","unstructured":"Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350:2572\u20132581","journal-title":"N Engl J Med"},{"key":"8553_CR221","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/ard.2006.057885","volume":"66","author":"M Tokunaga","year":"2007","unstructured":"Tokunaga M, Saito K, Kawabata D, Imura Y, Fujii T, Nakayamada S, Tsujimura S, Nawata M, Iwata S, Azuma T, Mimori T, Tanaka Y (2007) Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system. Ann Rheum Dis 66:470\u2013475","journal-title":"Ann Rheum Dis"},{"key":"8553_CR222","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/art.22536","volume":"57","author":"V Devauchelle-Pensec","year":"2007","unstructured":"Devauchelle-Pensec V, Pennec Y, Morvan J, Pers JO, Daridon C, Jousse-Joulin S, Roudaut A, Jamin C, Renaudineau Y, Roue IQ, Cochener B, Youinou P, Saraux A (2007) Improvement of Sjogren\u2019s syndrome after two infusions of rituximab (anti-CD20). Arthritis Rheum 57:310\u2013317","journal-title":"Arthritis Rheum"},{"key":"8553_CR223","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jneuroim.2006.06.029","volume":"180","author":"AH Cross","year":"2006","unstructured":"Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA (2006) Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 180:63\u201370","journal-title":"J Neuroimmunol"},{"key":"8553_CR224","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1600-0404.2007.00958.x","volume":"117","author":"HF Petereit","year":"2008","unstructured":"Petereit HF, Moeller-Hartmann W, Reske D, Rubbert A (2008) Rituximab in a patient with multiple sclerosis\u2014effect on B cells, plasma cells and intrathecal IgG synthesis. Acta Neurol Scand 117:399\u2013403","journal-title":"Acta Neurol Scand"},{"key":"8553_CR225","first-page":"423971","volume":"2011","author":"S Ireland","year":"2011","unstructured":"Ireland S, Monson N (2011) Potential impact of B cells on T cell function in multiple sclerosis. Mult Scler Int 2011:423971","journal-title":"Mult Scler Int"},{"key":"8553_CR226","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4049\/jimmunol.156.1.56","volume":"156","author":"JA Lederer","year":"1996","unstructured":"Lederer JA, Liou JS, Kim S, Rice N, Lichtman AH (1996) Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells. J Immunol 156:56\u201363","journal-title":"J Immunol"},{"key":"8553_CR227","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/0008-5472.264.65.1","volume":"65","author":"AR Jazirehi","year":"2005","unstructured":"Jazirehi AR, Huerta-Yepez S, Cheng G, Bonavida B (2005) Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-{kappa}B signaling pathway in non-Hodgkin\u2019s lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res 65:264\u2013276","journal-title":"Cancer Res"},{"key":"8553_CR228","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar1954","volume":"8","author":"M Vigna-Perez","year":"2006","unstructured":"Vigna-Perez M, Hernandez-Castro B, Paredes-Saharopulos O, Portales-Perez D, Baranda L, Abud-Mendoza C, Gonzalez-Amaro R (2006) Clinical and immunological effects of rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study. Arthritis Res Ther 8:R83","journal-title":"Arthritis Res Ther"},{"key":"8553_CR229","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMp0708143","volume":"358","author":"HF McFarland","year":"2008","unstructured":"McFarland HF (2008) The B cell\u2014old player, new position on the team. N Engl J Med 358:664\u2013665","journal-title":"N Engl J Med"},{"key":"8553_CR230","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/ana.21939","volume":"67","author":"A Bar-Or","year":"2010","unstructured":"Bar-Or A, Fawaz L, Fan B, Darlington PJ, Rieger A, Ghorayeb C, Calabresi PA, Waubant E, Hauser SL, Zhang J, Smith CH (2010) Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol 67:452\u2013461","journal-title":"Ann Neurol"},{"key":"8553_CR231","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/archneur.62.2.258","volume":"62","author":"NL Monson","year":"2005","unstructured":"Monson NL, Cravens PD, Frohman EM, Hawker K, Racke MK (2005) Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis. Arch Neurol 62:258\u2013264","journal-title":"Arch Neurol"},{"key":"8553_CR232","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2174\/187152412802430110","volume":"12","author":"M Geffard","year":"2012","unstructured":"Geffard M, Duleu S, Bessede A, Vigier V, Bodet D, Mangas A, Covenas R (2012) GEMSP: a new therapeutic approach to multiple sclerosis. Cent Nerv Syst Agents Med Chem 12:173\u2013181","journal-title":"Cent Nerv Syst Agents Med Chem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-013-8553-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-013-8553-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-013-8553-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T20:53:08Z","timestamp":1688503988000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-013-8553-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,26]]},"references-count":232,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["8553"],"URL":"https:\/\/doi.org\/10.1007\/s12035-013-8553-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,26]]}}}