{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:57:48Z","timestamp":1792684668860,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T00:00:00Z","timestamp":1400284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s12035-014-8743-4","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T04:06:38Z","timestamp":1400213198000},"page":"661-671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Pan-PPAR Modulation Effectively Protects APP\/PS1 Mice from Amyloid Deposition and Cognitive Deficits"],"prefix":"10.1007","volume":"51","author":[{"given":"Markus P.","family":"Kummer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Schwarzenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakina","family":"Sayah-Jeanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Dubernet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean W.","family":"Hum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Axt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Heneka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,17]]},"reference":[{"key":"8743_CR1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"HW Querfurth","year":"2010","unstructured":"Querfurth HW, LaFerla FM (2010) Alzheimer\u2019s disease. N Engl J Med 362:329\u2013344. doi: 10.1056\/NEJMra0909142","journal-title":"N Engl J Med"},{"key":"8743_CR2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","volume":"12","author":"CR Jack Jr","year":"2013","unstructured":"Jack CR Jr, Knopman DS, Jagust WJ et al (2013) Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12:207\u2013216. doi: 10.1016\/S1474-4422(12)70291-0","journal-title":"Lancet Neurol"},{"key":"8743_CR3","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","volume":"13","author":"JJ Palop","year":"2010","unstructured":"Palop JJ, Mucke L (2010) Amyloid-\u03b2 induced neuronal dysfunction in Alzheimer\u2019s disease: from synapses toward neural networks. Nat Neurosci 13:812\u2013818. doi: 10.1038\/nn.2583","journal-title":"Nat Neurosci"},{"key":"8743_CR4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nn.3028","volume":"15","author":"I Benilova","year":"2012","unstructured":"Benilova I, Karran E, De Strooper B (2012) The toxic A\u03b2 oligomer and Alzheimer\u2019s disease: an emperor in need of clothes. Nat Neurosci 15:349\u2013357. doi: 10.1038\/nn.3028","journal-title":"Nat Neurosci"},{"key":"8743_CR5","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMoa010178","volume":"345","author":"BA In t\u2019 Veld","year":"2001","unstructured":"In t\u2019 Veld BA, Ruitenberg A, Hofman A et al (2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer\u2019s disease. N Engl J Med 345:1515\u20131521. doi: 10.1056\/NEJMoa010178","journal-title":"N Engl J Med"},{"key":"8743_CR6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/1531-8249(20010201)49:2<276::AID-ANA53>3.0.CO;2-5","volume":"49","author":"MT Heneka","year":"2001","unstructured":"Heneka MT, Landreth GE, Feinstein DL (2001) Role for peroxisome proliferator-activated receptor-gamma in Alzheimer\u2019s disease. Ann Neurol 49:276","journal-title":"Ann Neurol"},{"key":"8743_CR7","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1074\/jbc.272.6.3406","volume":"272","author":"JM Lehmann","year":"1997","unstructured":"Lehmann JM, Lenhard JM, Oliver BB et al (1997) Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406\u20133410","journal-title":"J Biol Chem"},{"key":"8743_CR8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/35154","volume":"391","author":"C Jiang","year":"1998","unstructured":"Jiang C, Ting AT, Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82\u201386. doi: 10.1038\/34184","journal-title":"Nature"},{"key":"8743_CR9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","volume":"391","author":"M Ricote","year":"1998","unstructured":"Ricote M, Li AC, Willson TM et al (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79\u201382. doi: 10.1038\/34178","journal-title":"Nature"},{"key":"8743_CR10","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.bbalip.2007.04.016","volume":"1771","author":"MT Heneka","year":"2007","unstructured":"Heneka MT, Landreth GE (2007) PPARs in the brain. Biochim Biophys Acta 1771:1031\u20131045. doi: 10.1016\/j.bbalip.2007.04.016","journal-title":"Biochim Biophys Acta"},{"key":"8743_CR11","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1523\/JNEUROSCI.23-20-07504.2003","volume":"23","author":"Q Yan","year":"2003","unstructured":"Yan Q, Zhang J, Liu H et al (2003) Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer\u2019s disease. J Neurosci Off J Soc Neurosci 23:7504\u20137509","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR12","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/brain\/awh452","volume":"128","author":"MT Heneka","year":"2005","unstructured":"Heneka MT, Sastre M, Dumitrescu-Ozimek L et al (2005) Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain J Neurol 128:1442\u20131453. doi: 10.1093\/brain\/awh452","journal-title":"Brain J Neurol"},{"key":"8743_CR13","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1523\/JNEUROSCI.20-02-00558.2000","volume":"20","author":"CK Combs","year":"2000","unstructured":"Combs CK, Johnson DE, Karlo JC et al (2000) Inflammatory mechanisms in Alzheimer\u2019s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci Off J Soc Neurosci 20:558\u2013567","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)02480-0","volume":"941","author":"EJ Kim","year":"2002","unstructured":"Kim EJ, Kwon KJ, Park JY et al (2002) Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2. Brain Res 941:1\u201310","journal-title":"Brain Res"},{"key":"8743_CR15","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1074\/jbc.M414390200","volume":"280","author":"R Luna-Medina","year":"2005","unstructured":"Luna-Medina R, Cortes-Canteli M, Alonso M et al (2005) Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. J Biol Chem 280:21453\u201321462. doi: 10.1074\/jbc.M414390200","journal-title":"J Biol Chem"},{"key":"8743_CR16","doi-asserted-by":"crossref","first-page":"9796","DOI":"10.1523\/JNEUROSCI.23-30-09796.2003","volume":"23","author":"M Sastre","year":"2003","unstructured":"Sastre M, Dewachter I, Landreth GE et al (2003) Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci Off J Soc Neurosci 23:9796\u20139804","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","volume":"103","author":"M Sastre","year":"2006","unstructured":"Sastre M, Dewachter I, Rossner S et al (2006) Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A 103:443\u2013448. doi: 10.1073\/pnas.0503839103","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8743_CR18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3233\/JAD-2006-10113","volume":"10","author":"SM Monte De la","year":"2006","unstructured":"De la Monte SM, Tong M, Lester-Coll N et al (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer\u2019s disease. J Alzheimers Dis JAD 10:89\u2013109","journal-title":"J Alzheimers Dis JAD"},{"key":"8743_CR19","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nrendo.2010.89","volume":"6","author":"A Hiukka","year":"2010","unstructured":"Hiukka A, Maranghi M, Matikainen N, Taskinen M-R (2010) PPARalpha: an emerging therapeutic target in diabetic microvascular damage. Nat Rev Endocrinol 6:454\u2013463. doi: 10.1038\/nrendo.2010.89","journal-title":"Nat Rev Endocrinol"},{"key":"8743_CR20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/ATVBAHA.110.221267","volume":"31","author":"K-J Yin","year":"2011","unstructured":"Yin K-J, Deng Z, Hamblin M et al (2011) Vascular PPAR\u03b4 protects against stroke-induced brain injury. Arterioscler Thromb Vasc Biol 31:574\u2013581. doi: 10.1161\/ATVBAHA.110.221267","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"8743_CR21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneuroim.2005.07.006","volume":"168","author":"PE Polak","year":"2005","unstructured":"Polak PE, Kalinin S, Dello Russo C et al (2005) Protective effects of a peroxisome proliferator-activated receptor-beta\/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol 168:65\u201375. doi: 10.1016\/j.jneuroim.2005.07.006","journal-title":"J Neuroimmunol"},{"key":"8743_CR22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2174\/156720509789207949","volume":"6","author":"S Kalinin","year":"2009","unstructured":"Kalinin S, Richardson JC, Feinstein DL (2009) A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer\u2019s disease. Curr Alzheimer Res 6:431\u2013437","journal-title":"Curr Alzheimer Res"},{"key":"8743_CR23","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1124\/jpet.106.115758","volume":"320","author":"A Iwashita","year":"2007","unstructured":"Iwashita A, Muramatsu Y, Yamazaki T et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo. J Pharmacol Exp Ther 320:1087\u20131096. doi: 10.1124\/jpet.106.115758","journal-title":"J Pharmacol Exp Ther"},{"key":"8743_CR24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1124\/jpet.110.165605","volume":"333","author":"I Paterniti","year":"2010","unstructured":"Paterniti I, Esposito E, Mazzon E et al (2010) Evidence for the role of peroxisome proliferator-activated receptor-beta\/delta in the development of spinal cord injury. J Pharmacol Exp Ther 333:465\u2013477. doi: 10.1124\/jpet.110.165605","journal-title":"J Pharmacol Exp Ther"},{"key":"8743_CR25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","volume":"17","author":"JL Jankowsky","year":"2001","unstructured":"Jankowsky JL, Slunt HH, Ratovitski T et al (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17:157\u2013165","journal-title":"Biomol Eng"},{"key":"8743_CR26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuint.2010.02.001","volume":"57","author":"D Jardanhazi-Kurutz","year":"2010","unstructured":"Jardanhazi-Kurutz D, Kummer MP, Terwel D et al (2010) Induced LC degeneration in APP\/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem Int 57:375\u2013382. doi: 10.1016\/j.neuint.2010.02.001","journal-title":"Neurochem Int"},{"key":"8743_CR27","author":"S J\u00e4ger","year":"2009","unstructured":"J\u00e4ger S, Leuchtenberger S, Martin A et al (2009) Alpha-secretase mediated conversion of the Amyloid Precursor Protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem. doi: 10.1111\/j.1471-4159.2009.06420.x","journal-title":"J Neurochem"},{"key":"8743_CR28","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/jnen\/61.9.797","volume":"61","author":"WE Klunk","year":"2002","unstructured":"Klunk WE, Bacskai BJ, Mathis CA et al (2002) Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol 61:797\u2013805","journal-title":"J Neuropathol Exp Neurol"},{"key":"8743_CR29","doi-asserted-by":"crossref","first-page":"12838","DOI":"10.1523\/JNEUROSCI.1982-06.2006","volume":"26","author":"T Wahle","year":"2006","unstructured":"Wahle T, Thal DR, Sastre M et al (2006) GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J Neurosci Off J Soc Neurosci 26:12838\u201312846. doi: 10.1523\/JNEUROSCI.1982-06.2006","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR30","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1523\/JNEUROSCI.6546-10.2011","volume":"31","author":"D Terwel","year":"2011","unstructured":"Terwel D, Steffensen KR, Verghese PB et al (2011) Critical role of astroglial apolipoprotein E and liver X receptor-\u03b1 expression for microglial A\u03b2 phagocytosis. J Neurosci Off J Soc Neurosci 31:7049\u20137059. doi: 10.1523\/JNEUROSCI.6546-10.2011","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR31","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1217697","volume":"335","author":"PE Cramer","year":"2012","unstructured":"Cramer PE, Cirrito JR, Wesson DW et al (2012) ApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models. Science 335:1503\u20131506. doi: 10.1126\/science.1217697","journal-title":"Science"},{"key":"8743_CR32","first-page":"2508","volume":"168","author":"A Diab","year":"1950","unstructured":"Diab A, Deng C, Smith JD et al (1950) (2002) Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. J Immunol Baltim Md 168:2508\u20132515","journal-title":"J Immunol Baltim Md"},{"key":"8743_CR33","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1471-4159.2003.02210.x","volume":"88","author":"T Dehmer","year":"2004","unstructured":"Dehmer T, Heneka MT, Sastre M et al (2004) Protection by pioglitazone in the MPTP model of Parkinson\u2019s disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem 88:494\u2013501","journal-title":"J Neurochem"},{"key":"8743_CR34","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJMp1309610","volume":"369","author":"WR Hiatt","year":"2013","unstructured":"Hiatt WR, Kaul S, Smith RJ (2013) The cardiovascular safety of diabetes drugs\u2014insights from the rosiglitazone experience. N Engl J Med 369:1285\u20131287. doi: 10.1056\/NEJMp1309610","journal-title":"N Engl J Med"},{"key":"8743_CR35","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0197-0186(01)00052-3","volume":"39","author":"CK Combs","year":"2001","unstructured":"Combs CK, Bates P, Karlo JC, Landreth GE (2001) Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha. Neurochem Int 39:449\u2013457","journal-title":"Neurochem Int"},{"key":"8743_CR36","doi-asserted-by":"crossref","first-page":"17321","DOI":"10.1523\/JNEUROSCI.1569-12.2012","volume":"32","author":"M Yamanaka","year":"2012","unstructured":"Yamanaka M, Ishikawa T, Griep A et al (2012) PPAR\u03b3\/RXR\u03b1-induced and CD36-mediated microglial amyloid-\u03b2 phagocytosis results in cognitive improvement in amyloid precursor protein\/presenilin 1 mice. J Neurosci Off J Soc Neurosci 32:17321\u201317331. doi: 10.1523\/JNEUROSCI.1569-12.2012","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR37","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","volume":"330","author":"KG Mawuenyega","year":"2010","unstructured":"Mawuenyega KG, Sigurdson W, Ovod V et al (2010) Decreased clearance of CNS \u03b2-amyloid in Alzheimer\u2019s disease. Science 330:1774. doi: 10.1126\/science.1197623","journal-title":"Science"},{"key":"8743_CR38","doi-asserted-by":"crossref","first-page":"11982","DOI":"10.1523\/JNEUROSCI.3158-09.2009","volume":"29","author":"EG Reed-Geaghan","year":"2009","unstructured":"Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE (2009) CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci Off J Soc Neurosci 29:11982\u201311992. doi: 10.1523\/JNEUROSCI.3158-09.2009","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"8743_CR39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1742-2094-2-22","volume":"2","author":"MT Heneka","year":"2005","unstructured":"Heneka MT, Sastre M, Dumitrescu-Ozimek L et al (2005) Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J Neuroinflammation 2:22. doi: 10.1186\/1742-2094-2-22","journal-title":"J Neuroinflammation"},{"key":"8743_CR40","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuron.2011.07.001","volume":"71","author":"MP Kummer","year":"2011","unstructured":"Kummer MP, Hermes M, Delekarte A et al (2011) Nitration of tyrosine 10 critically enhances amyloid \u03b2 aggregation and plaque formation. Neuron 71:833\u2013844. doi: 10.1016\/j.neuron.2011.07.001","journal-title":"Neuron"},{"key":"8743_CR41","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nri912","volume":"2","author":"RA Daynes","year":"2002","unstructured":"Daynes RA, Jones DC (2002) Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2:748\u2013759. doi: 10.1038\/nri912","journal-title":"Nat Rev Immunol"},{"key":"8743_CR42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/384039a0","volume":"384","author":"PR Devchand","year":"1996","unstructured":"Devchand PR, Keller H, Peters JM et al (1996) The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384:39\u201343. doi: 10.1038\/384039a0","journal-title":"Nature"},{"key":"8743_CR43","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cardiores.2005.10.019","volume":"69","author":"M Pesant","year":"2006","unstructured":"Pesant M, Sueur S, Dutartre P et al (2006) Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovasc Res 69:440\u2013449. doi: 10.1016\/j.cardiores.2005.10.019","journal-title":"Cardiovasc Res"},{"key":"8743_CR44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/cvr\/cvs266","volume":"96","author":"LV D\u2019 Uscio","year":"2012","unstructured":"D\u2019 Uscio LV, Das P, Santhanam AVR et al (2012) Activation of PPAR\u03b4 prevents endothelial dysfunction induced by overexpression of amyloid-\u03b2 precursor protein. Cardiovasc Res 96:504\u2013512. doi: 10.1093\/cvr\/cvs266","journal-title":"Cardiovasc Res"},{"key":"8743_CR45","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/387500a0","volume":"387","author":"J Nalbantoglu","year":"1997","unstructured":"Nalbantoglu J, Tirado-Santiago G, Lahsaini A et al (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387:500\u2013505. doi: 10.1038\/387500a0","journal-title":"Nature"},{"key":"8743_CR46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","volume":"416","author":"DM Walsh","year":"2002","unstructured":"Walsh DM, Klyubin I, Fadeeva JV et al (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535\u2013539. doi: 10.1038\/416535a","journal-title":"Nature"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-014-8743-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-014-8743-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-014-8743-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T10:30:34Z","timestamp":1565433034000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-014-8743-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,17]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["8743"],"URL":"https:\/\/doi.org\/10.1007\/s12035-014-8743-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,17]]}}}