{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:38:22Z","timestamp":1791185902607,"version":"4.1.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s12035-014-8957-5","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T15:58:25Z","timestamp":1415980705000},"page":"1670-1679","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 Receptor Antagonists"],"prefix":"10.1007","volume":"52","author":[{"given":"Gohar","family":"Fakhfouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Mousavizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharam Ejtemaei","family":"Mehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Zirak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Eric","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rahimian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"issue":"1","key":"8957_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2174\/157339506775471893","volume":"2","author":"I Cloez-Tayarani","year":"2006","unstructured":"Cloez-Tayarani I (2006) Serotonin as a modulator of immune function: an overview. Curr Immunol Rev 2(1):27\u201335. doi: 10.2174\/157339506775471893","journal-title":"Curr Immunol Rev"},{"issue":"5030","key":"8957_CR2","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1126\/science.1718042","volume":"254","author":"AV Maricq","year":"1991","unstructured":"Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D (1991) Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science 254(5030):432\u2013437. doi: 10.1126\/science.1718042","journal-title":"Science"},{"issue":"4","key":"8957_CR3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1517\/14728222.11.4.527","volume":"11","author":"AJ Thompson","year":"2007","unstructured":"Thompson AJ, Lummis SCR (2007) The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets 11(4):527\u2013540. doi: 10.1517\/14728222.11.4.527","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"8957_CR4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.neuropharm.2008.08.003","volume":"56","author":"NM Barnes","year":"2009","unstructured":"Barnes NM, Hales TG, Lummis SCR, Peters JA (2009) The 5-HT3 receptor\u2014the relationship between structure and function. Neuropharmacology 56(1):273\u2013284. doi: 10.1016\/j.neuropharm.2008.08.003","journal-title":"Neuropharmacology"},{"key":"8957_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/03009740410006952","volume":"119","author":"BL Fiebich","year":"2004","unstructured":"Fiebich BL, Akundi RS, Seidel M, Geyer V, Haus U, Muller W, Stratz T, Candelario-Jalil E (2004) Expression of 5-HT3A receptors in cells of the immune system. Scand J Rheumatol Suppl 119:9\u201311. doi: 10.1080\/03009740410006952","journal-title":"Scand J Rheumatol Suppl"},{"issue":"4","key":"8957_CR6","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1073\/pnas.90.4.1430","volume":"90","author":"LH Tecott","year":"1993","unstructured":"Tecott LH, Maricq AV, Julius D (1993) Nervous system distribution of the serotonin 5-HT3 receptor mRNA. Proc Natl Acad Sci U S A 90(4):1430\u20131434. doi: 10.1073\/pnas.90.4.1430","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"28","key":"8957_CR7","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.2174\/138161206778522029","volume":"12","author":"AJ Thompson","year":"2006","unstructured":"Thompson AJ, Lummis SC (2006) 5-HT3 receptors. Curr Pharm Des 12(28):3615\u20133630","journal-title":"Curr Pharm Des"},{"issue":"1","key":"8957_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2007.01.028","volume":"560","author":"L Faerber","year":"2007","unstructured":"Faerber L, Drechsler S, Ladenburger S, Gschaidmeier H, Fischer W (2007) The neuronal 5-HT3 receptor network after 20 years of research\u2014evolving concepts in management of pain and inflammation. Eur J Pharmacol 560(1):1\u20138. doi: 10.1016\/j.ejphar.2007.01.028","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"8957_CR9","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1212\/WNL.59.6.880","volume":"59","author":"PP Zandi","year":"2002","unstructured":"Zandi PP, Anthony JC, Hayden KM, Mehta K, Mayer L, Breitner JC, Cache County Study I (2002) Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology 59(6):880\u2013886. doi: 10.1212\/WNL.59.6.880","journal-title":"Neurology"},{"issue":"1","key":"8957_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.yexcr.2004.09.032","volume":"304","author":"NC Inestrosa","year":"2005","unstructured":"Inestrosa NC, Godoy JA, Quintanilla RA, Koenig CS, Bronfman M (2005) Peroxisome proliferator-activated receptor \u03b3 is expressed in hippocampal neurons and its activation prevents \u03b2-amyloid neurodegeneration: role of Wnt signaling. Exp Cell Res 304(1):91\u2013104. doi: 10.1016\/j.yexcr.2004.09.032","journal-title":"Exp Cell Res"},{"issue":"5","key":"8957_CR11","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/sj.bjp.0707446","volume":"152","author":"VA Campbell","year":"2007","unstructured":"Campbell VA, Gowran A (2007) Alzheimer\u2019s disease; taking the edge off with cannabinoids? Br J Pharmacol 152(5):655\u2013662. doi: 10.1038\/sj.bjp.0707446","journal-title":"Br J Pharmacol"},{"issue":"1","key":"8957_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0304-3940(92)90322-X","volume":"141","author":"H Tohgi","year":"1992","unstructured":"Tohgi H, Abe T, Takahashi S, Kimura M, Takahashi J, Kikuchi T (1992) Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia. Neurosci Lett 141(1):9\u201312. doi: 10.1016\/0304-3940(92)90322-X","journal-title":"Neurosci Lett"},{"issue":"6","key":"8957_CR13","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1111\/j.1471-4159.1992.tb10983.x","volume":"58","author":"G Maura","year":"1992","unstructured":"Maura G, Andrioli GC, Cavazzani P, Raiteri M (1992) 5-Hydroxytryptamine3 receptors sited on cholinergic axon terminals of human cerebral cortex mediate inhibition of acetylcholine release. J Neurochem 58(6):2334\u20132337. doi: 10.1111\/j.1471-4159.1992.tb10983.x","journal-title":"J Neurochem"},{"issue":"4","key":"8957_CR14","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1124\/pr.59.07103","volume":"59","author":"KB Fink","year":"2007","unstructured":"Fink KB, G\u00f6thert M (2007) 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev 59(4):360\u2013417. doi: 10.1124\/pr.59.07103","journal-title":"Pharmacol Rev"},{"issue":"1\u20132","key":"8957_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0006-8993(97)00448-4","volume":"762","author":"M Ohno","year":"1997","unstructured":"Ohno M, Watanabe S (1997) Differential effects of 5-HT3 receptor antagonism on working memory failure due to deficiency of hippocampal cholinergic and glutamatergic transmission in rats. Brain Res 762(1\u20132):211\u2013215. doi: 10.1016\/S0006-8993(97)00448-4","journal-title":"Brain Res"},{"issue":"2","key":"8957_CR16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0166-4328(97)80988-6","volume":"82","author":"M Carli","year":"1997","unstructured":"Carli M, Luschi R, Samanin R (1997) Dose-related impairment of spatial learning by intrahippocampal scopolamine: antagonism by ondansetron, a 5-HT3 receptor antagonist. Behav Brain Res 82(2):185\u2013194. doi: 10.1016\/S0166-4328(97)80988-6","journal-title":"Behav Brain Res"},{"issue":"2","key":"8957_CR17","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0306-4522(89)90382-5","volume":"31","author":"C Waeber","year":"1989","unstructured":"Waeber C, Hoyer D, Palacios JM (1989) 5-Hydroxytryptamine3 receptors in the human brain: autoradiographic visualization using [3H]ICS 205-930. Neuroscience 31(2):393\u2013400. doi: 10.1016\/0306-4522(89)90382-5","journal-title":"Neuroscience"},{"issue":"3","key":"8957_CR18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1006\/nlme.1998.3886","volume":"71","author":"C Boast","year":"1999","unstructured":"Boast C, Bartolomeo AC, Morris H, Moyer JA (1999) 5HT antagonists attenuate MK801-impaired radial arm maze performance in rats. Neurobiol Learn Mem 71(3):259\u2013271. doi: 10.1006\/nlme.1998.3886","journal-title":"Neurobiol Learn Mem"},{"issue":"1\u20133","key":"8957_CR19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.brainresrev.2004.07.018","volume":"47","author":"RA Fuentealba","year":"2004","unstructured":"Fuentealba RA, Farias G, Scheu J, Bronfman M, Marzolo MP, Inestrosa NC (2004) Signal transduction during amyloid-\u03b2-peptide neurotoxicity: role in Alzheimer disease. Brain Res Rev 47(1\u20133):275\u2013289. doi: 10.1016\/j.brainresrev.2004.07.018","journal-title":"Brain Res Rev"},{"issue":"1\u20133","key":"8957_CR20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejphar.2005.07.021","volume":"520","author":"B Ju Yeon","year":"2005","unstructured":"Ju Yeon B, Yeon Hee S (2005) Blockade of 5-HT3 receptor with MDL72222 and Y25130 reduces \u03b2-amyloid protein (25\u201335)-induced neurotoxicity in cultured rat cortical neurons. Eur J Pharmacol 520(1\u20133):12\u201321. doi: 10.1016\/j.ejphar.2005.07.021","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"8957_CR21","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/eci.12141","volume":"43","author":"R Rahimian","year":"2013","unstructured":"Rahimian R, Fakhfouri G, Ejtemaei Mehr S, Ghia J-E, Genazzani AA, Payandemehr B, Dehpour AR, Mousavizadeh K, Lim D (2013) Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Investig 43(10):1039\u20131051. doi: 10.1111\/eci.12141","journal-title":"Eur J Clin Investig"},{"issue":"20","key":"8957_CR22","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.1523\/jneurosci. 5047-06.2007","volume":"27","author":"R Medeiros","year":"2007","unstructured":"Medeiros R, Prediger RDS, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB (2007) Connecting TNF-\u03b1 signaling pathways to inos expression in a mouse model of alzheimer\u2019s disease: relevance for the behavioral and synaptic deficits induced by amyloid \u03b2 protein. J Neurosci 27(20):5394\u20135404. doi: 10.1523\/jneurosci. 5047-06.2007","journal-title":"J Neurosci"},{"issue":"1","key":"8957_CR23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.bbr.2010.01.040","volume":"209","author":"R Medeiros","year":"2010","unstructured":"Medeiros R, Figueiredo CP, Pandolfo P, Duarte FS, Prediger RDS, Passos GF, Calixto JB (2010) The role of TNF-\u03b1 signaling pathway on COX-2 upregulation and cognitive decline induced by \u03b2-amyloid peptide. Behav Brain Res 209(1):165\u2013173. doi: 10.1016\/j.bbr.2010.01.040","journal-title":"Behav Brain Res"},{"issue":"4","key":"8957_CR24","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.bbrc.2003.10.046","volume":"311","author":"IM Mansuy","year":"2003","unstructured":"Mansuy IM (2003) Calcineurin in memory and bidirectional plasticity. Biochem Biophys Res Commun 311(4):1195\u20131208. doi: 10.1016\/j.bbrc.2003.10.046","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"8957_CR25","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1523\/jneurosci. 4456-09.2010","volume":"30","author":"H-Y Wu","year":"2010","unstructured":"Wu H-Y, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT (2010) Amyloid \u03b2 induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J Neurosci 30(7):2636\u20132649. doi: 10.1523\/jneurosci. 4456-09.2010","journal-title":"J Neurosci"},{"issue":"1","key":"8957_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0092-8674(00)80897-1","volume":"92","author":"IM Mansuy","year":"1998","unstructured":"Mansuy IM, Mayford M, Jacob B, Kandel ER, Bach ME (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92(1):39\u201349. doi: 10.1016\/S0092-8674(00)80897-1","journal-title":"Cell"},{"issue":"2","key":"8957_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0896-6273(00)80533-4","volume":"21","author":"IM Mansuy","year":"1998","unstructured":"Mansuy IM, Winder DG, Moallem TM, Osman M, Mayford M, Hawkins RD, Kandel ER (1998) Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron 21(2):257\u2013265. doi: 10.1016\/S0896-6273(00)80533-4","journal-title":"Neuron"},{"issue":"1","key":"8957_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0165-3806(91)90071-P","volume":"63","author":"JW Polli","year":"1991","unstructured":"Polli JW, Billingsley ML, Kincaid RL (1991) Expression of the calmodulin-dependent protein phosphatase, calcineurin, in rat brain: developmental patterns and the role of nigrostriatal innervation. Dev Brain Res 63(1):105\u2013119. doi: 10.1016\/0165-3806(91)90071-P","journal-title":"Dev Brain Res"},{"issue":"1","key":"8957_CR29","first-page":"7","volume":"2","author":"HM Abdul","year":"2010","unstructured":"Abdul HM, Furman JL, Sama MA, Mathis DM, Norris CM (2010) NFATs and Alzheimer\u2019s disease. Mol Cell Pharmacol 2(1):7","journal-title":"Mol Cell Pharmacol"},{"issue":"4","key":"8957_CR30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.intimp.2012.05.013","volume":"13","author":"C Stratz","year":"2012","unstructured":"Stratz C, Bhatia HS, Akundi RS, N\u00fchrenberg T, Trenk D, Mu\u00f1oz E, Fiebich BL (2012) The anti-inflammatory effects of the 5-HT3 receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes. Int Immunopharmacol 13(4):398\u2013402. doi: 10.1016\/j.intimp.2012.05.013","journal-title":"Int Immunopharmacol"},{"key":"8957_CR31","doi-asserted-by":"publisher","first-page":"S177","DOI":"10.3233\/JAD-132621","volume":"42","author":"D Z\u00e1dori","year":"2014","unstructured":"Z\u00e1dori D, Veres G, Szal\u00e1rdy L, Kliv\u00e9nyi P, Toldi J, V\u00e9csei L (2014) Glutamatergic dysfunctioning in Alzheimer\u2019s disease and related therapeutic targets. J Alzheimers Dis 42:S177\u2013S187. doi: 10.3233\/JAD-132621","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"8957_CR32","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1165\/rcmb.2006-0151OC","volume":"36","author":"H Bayer","year":"2007","unstructured":"Bayer H, M\u00fcller T, Myrtek D, Sorichter S, Ziegenhagen M, Norgauer J, Zissel G, Idzko M (2007) Serotoninergic receptors on human airway epithelial cells. Am J Respir Cell Mol Biol 36(1):85\u201393. doi: 10.1165\/rcmb.2006-0151OC","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"8957_CR33","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/intimm\/dxh242","volume":"17","author":"T D\u00fcrk","year":"2005","unstructured":"D\u00fcrk T, Panther E, M\u00fcller T, Sorichter S, Ferrari D, Pizzirani C, Di Virgilio F, Myrtek D, Norgauer J, Idzko M (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int Immunol 17(5):599\u2013606. doi: 10.1093\/intimm\/dxh242","journal-title":"Int Immunol"},{"issue":"8","key":"8957_CR34","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1182\/blood-2006-10-052787","volume":"109","author":"M Le\u00f3n-Ponte","year":"2007","unstructured":"Le\u00f3n-Ponte M, Ahern GP, O\u2019Connell PJ (2007) Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood 109(8):3139\u20133146. doi: 10.1182\/blood-2006-10-052787","journal-title":"Blood"},{"issue":"3","key":"8957_CR35","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1182\/blood-2005-07-2903","volume":"107","author":"PJ O\u2019Connell","year":"2006","unstructured":"O\u2019Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP (2006) A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood 107(3):1010\u20131017. doi: 10.1182\/blood-2005-07-2903","journal-title":"Blood"},{"issue":"7","key":"8957_CR36","doi-asserted-by":"publisher","first-page":"e6453","DOI":"10.1371\/journal.pone.0006453","volume":"4","author":"T M\u00fcller","year":"2009","unstructured":"M\u00fcller T, D\u00fcrk T, Blumenthal B, Grimm M, Cicko S, Panther E, Sorichter S, Herouy Y, Di Virgilio F, Ferrari D, Norgauer J, Idzko M (2009) 5-Hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4(7):e6453. doi: 10.1371\/journal.pone.0006453","journal-title":"PLoS One"},{"issue":"1","key":"8957_CR37","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0165-5728(99)00101-0","volume":"99","author":"N-A Khan","year":"1999","unstructured":"Khan N-A, Poisson J-P (1999) 5-HT3 receptor-channels coupled with Na\u2009+\u2009influx in human T cells: role in T cell activation. J Neuroimmunol 99(1):53\u201360. doi: 10.1016\/S0165-5728(99)00101-0","journal-title":"J Neuroimmunol"},{"issue":"1","key":"8957_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1742-2094-10-35","volume":"10","author":"D Vogel","year":"2013","unstructured":"Vogel D, Vereyken E, Glim JE, Heijnen P, Moeton M, van der Valk P, Amor S, Teunissen CE, van Horssen J, Dijkstra CD (2013) Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J Neuroinflammation 10(1):35. doi: 10.1186\/1742-2094-10-35","journal-title":"J Neuroinflammation"},{"issue":"3","key":"8957_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s001090050101","volume":"75","author":"EN Benveniste","year":"1997","unstructured":"Benveniste EN (1997) Role of macrophages\/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 75(3):165\u2013173. doi: 10.1007\/s001090050101","journal-title":"J Mol Med"},{"issue":"6","key":"8957_CR40","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/eji.1830210620","volume":"21","author":"J-B Sun","year":"1991","unstructured":"Sun J-B, Olsson T, Wang W-Z, Xiao B-G, Kostulas V, Fredrikson S, Ekre H-P, Link H (1991) Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 21(6):1461\u20131468. doi: 10.1002\/eji.1830210620","journal-title":"Eur J Immunol"},{"issue":"1","key":"8957_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00415-008-1002-8","volume":"255","author":"H Weiner","year":"2008","unstructured":"Weiner H (2008) A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J Neurol 255(1):3\u201311. doi: 10.1007\/s00415-008-1002-8","journal-title":"J Neurol"},{"key":"8957_CR42","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.neuroscience.2013.06.009","volume":"248","author":"A Aminian","year":"2013","unstructured":"Aminian A, Noorbakhsh F, Ghazi-Khansari M, Kafami L, Javadi S, Hassanzadeh G, Rahimian R, Dehpour AR, Mehr SE (2013) Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. Neuroscience 248:299\u2013306. doi: 10.1016\/j.neuroscience.2013.06.009","journal-title":"Neuroscience"},{"issue":"13\u201314","key":"8957_CR43","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.drudis.2012.02.009","volume":"17","author":"G Fakhfouri","year":"2012","unstructured":"Fakhfouri G, Rahimian R, Ghia J-E, Khan WI, Dehpour AR (2012) Impact of 5-HT3 receptor antagonists on peripheral and central diseases. Drug Discov Today 17(13\u201314):741\u2013747. doi: 10.1016\/j.drudis.2012.02.009","journal-title":"Drug Discov Today"},{"issue":"4","key":"8957_CR44","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri1807","volume":"6","author":"C Dong","year":"2006","unstructured":"Dong C (2006) Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6(4):329\u2013334. doi: 10.1038\/nri1807","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"8957_CR45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11481-009-9188-9","volume":"5","author":"M El-behi","year":"2010","unstructured":"El-behi M, Rostami A, Ciric B (2010) Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol Off J Soc NeuroImmune Pharmacol 5(2):189\u2013197. doi: 10.1007\/s11481-009-9188-9","journal-title":"J Neuroimmune Pharmacol Off J Soc NeuroImmune Pharmacol"},{"key":"8957_CR46","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.brainres.2010.07.037","volume":"1353","author":"S Kohnomi","year":"2010","unstructured":"Kohnomi S, Suemaru K, Goda M, Choshi T, Hibino S, Kawasaki H, Araki H (2010) Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the \u03b17 nicotinic acetylcholine receptor in Wistar rats. Brain Res 1353:152\u2013158. doi: 10.1016\/j.brainres.2010.07.037","journal-title":"Brain Res"},{"issue":"3","key":"8957_CR47","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/art.37809","volume":"65","author":"A Stegemann","year":"2013","unstructured":"Stegemann A, Sindrilaru A, Eckes B, del Rey A, Heinick A, Schulte JS, M\u00fcller FU, Grando SA, Fiebich BL, Scharffetter-Kochanek K, Luger TA, B\u00f6hm M (2013) Tropisetron suppresses collagen synthesis in skin fibroblasts via \u03b17 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. Arthritis Rheum 65(3):792\u2013804. doi: 10.1002\/art.37809","journal-title":"Arthritis Rheum"},{"issue":"7","key":"8957_CR48","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/sj.bjp.0707264","volume":"151","author":"WJ Jonge de","year":"2007","unstructured":"de Jonge WJ, Ulloa L (2007) The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol 151(7):915\u2013929. doi: 10.1038\/sj.bjp.0707264","journal-title":"Br J Pharmacol"},{"issue":"5","key":"8957_CR49","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1034\/j.1600-0404.2001.00075.x","volume":"104","author":"J Gbadamosi","year":"2001","unstructured":"Gbadamosi J, Buhmann C, Moench A, Heesen C (2001) Failure of ondansetron in treating cerebellar tremor in MS patients\u2014an open-label pilot study. Acta Neurol Scand 104(5):308\u2013311. doi: 10.1034\/j.1600-0404.2001.00075.x","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"8957_CR50","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1136\/jnnp.62.3.282","volume":"62","author":"GP Rice","year":"1997","unstructured":"Rice GP, Lesaux J, Vandervoort P, Macewan L, Ebers GC (1997) Ondansetron, a 5-HT3 antagonist, improves cerebellar tremor. J Neurol Neurosurg Psychiatry 62(3):282\u2013284. doi: 10.1136\/jnnp.62.3.282","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Suppl 3","key":"8957_CR51","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1017\/S0317167100048575","volume":"20","author":"P Trouillas","year":"1993","unstructured":"Trouillas P (1993) The cerebellar serotoninergic system and its possible involvement in cerebellar ataxia. Can J Neurol Sci J Can Sci Neurol 20(Suppl 3):S78\u201382","journal-title":"Can J Neurol Sci J Can Sci Neurol"},{"issue":"1","key":"8957_CR52","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0006-8993(79)90494-3","volume":"179","author":"MH Woert Van","year":"1979","unstructured":"Van Woert MH, Plaitakis A, Chung Hwang E, Berl S (1979) Effect of thiamine deficiency on brain serotonin turnover. Brain Res 179(1):103\u2013110. doi: 10.1016\/0006-8993(79)90494-3","journal-title":"Brain Res"},{"issue":"1","key":"8957_CR53","first-page":"70","volume":"66","author":"T Haenel","year":"1995","unstructured":"Haenel T, Stockli HR, Truog P (1995) A case of rare side effects of certain antidepressive drugs. Nervenarzt 66(1):70\u201372","journal-title":"Nervenarzt"},{"issue":"10","key":"8957_CR54","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1474-4422(05)70193-9","volume":"4","author":"J Kesselring","year":"2005","unstructured":"Kesselring J, Beer S (2005) Symptomatic therapy and neurorehabilitation in multiple sclerosis. Lancet Neurol 4(10):643\u2013652. doi: 10.1016\/S1474-4422(05)70193-9","journal-title":"Lancet Neurol"},{"issue":"5","key":"8957_CR55","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1213\/01.ANE.0000085640.69855.51","volume":"97","author":"GJ McCleane","year":"2003","unstructured":"McCleane GJ, Suzuki R, Dickenson AH (2003) Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth Analg 97(5):1474\u20131478. doi: 10.1213\/01.ANE.0000085640.69855.51","journal-title":"Anesth Analg"},{"issue":"4","key":"8957_CR56","first-page":"225","volume":"50","author":"A Norouzi","year":"2012","unstructured":"Norouzi A, Fakhfouri G, Rahimian R (2012) How can 5-HT3 receptor antagonists exert analgesic properties? Acta Med Iran 50(4):225","journal-title":"Acta Med Iran"},{"issue":"S1","key":"8957_CR57","doi-asserted-by":"publisher","first-page":"S232","DOI":"10.1038\/sj.bjp.0706400","volume":"147","author":"S-M Lucas","year":"2006","unstructured":"Lucas S-M, Rothwell NJ, Gibson RM (2006) The role of inflammation in CNS injury and disease. Br J Pharmacol 147(S1):S232\u2013S240. doi: 10.1038\/sj.bjp.0706400","journal-title":"Br J Pharmacol"},{"issue":"9","key":"8957_CR58","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","volume":"22","author":"U Dirnagl","year":"1999","unstructured":"Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22(9):391\u2013397. doi: 10.1016\/S0166-2236(99)01401-0","journal-title":"Trends Neurosci"},{"key":"8957_CR59","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.brainres.2011.03.053","volume":"1392","author":"R Rahimian","year":"2011","unstructured":"Rahimian R, Daneshmand A, Mehr SE, Barzegar-Fallah A, Mohammadi-Rick S, Fakhfouri G, Shabanzadeh AP, Dehpour AR (2011) Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. Brain Res 1392:101\u2013109. doi: 10.1016\/j.brainres.2011.03.053","journal-title":"Brain Res"},{"issue":"3","key":"8957_CR60","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.lfs.2005.04.043","volume":"78","author":"HJ Lee","year":"2005","unstructured":"Lee HJ, Ban JY, Seong YH (2005) Blockade of 5-HT3 receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci 78(3):294\u2013300. doi: 10.1016\/j.lfs.2005.04.043","journal-title":"Life Sci"},{"issue":"1","key":"8957_CR61","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0014-2999(92)94817-F","volume":"224","author":"Y Kagami-ishi","year":"1992","unstructured":"Kagami-ishi Y, Shibata S, Watanabe S (1992) Neuroprotective effect of 5-HT3 receptor antagonist on ischemia-induced decrease in CA1 field potential in rat hippocampal slices. Eur J Pharmacol 224(1):51\u201356. doi: 10.1016\/0014-2999(92)94817-F","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"8957_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2202-9-19","volume":"9","author":"E Candelario-Jalil","year":"2008","unstructured":"Candelario-Jalil E, Mu\u00f1oz E, Fiebich B (2008) Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neurosci 9(1):1\u20136. doi: 10.1186\/1471-2202-9-19","journal-title":"BMC Neurosci"},{"key":"8957_CR63","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuropharm.2013.05.020","volume":"73","author":"MM Swartz","year":"2013","unstructured":"Swartz MM, Linn DM, Linn CL (2013) Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology 73:111\u2013121. doi: 10.1016\/j.neuropharm.2013.05.020","journal-title":"Neuropharmacology"},{"key":"8957_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2011.08.050","volume":"1417","author":"R Rahimian","year":"2011","unstructured":"Rahimian R, Dehpour AR, Fakhfouri G, Khorramizadeh MR, Ghia J-E, Seyedabadi M, Caldarelli A, Mousavizadeh K, Forouzandeh M, Mehr SE (2011) Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res 1417:1\u20138. doi: 10.1016\/j.brainres.2011.08.050","journal-title":"Brain Res"},{"issue":"8","key":"8957_CR65","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10822-011-9447-8","volume":"25","author":"G Maggiora","year":"2011","unstructured":"Maggiora G (2011) The reductionist paradox: are the laws of chemistry and physics sufficient for the discovery of new drugs? J Comput Aided Mol Des 25(8):699\u2013708. doi: 10.1007\/s10822-011-9447-8","journal-title":"J Comput Aided Mol Des"},{"issue":"9\u201310","key":"8957_CR66","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.drudis.2013.01.008","volume":"18","author":"JL Medina-Franco","year":"2013","unstructured":"Medina-Franco JL, Giulianotti MA, Welmaker GS, Houghten RA (2013) Shifting from the single to the multitarget paradigm in drug discovery. Drug Discov Today 18(9\u201310):495\u2013501. doi: 10.1016\/j.drudis.2013.01.008","journal-title":"Drug Discov Today"},{"issue":"10","key":"8957_CR67","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1021\/jm0493461","volume":"48","author":"A Cappelli","year":"2005","unstructured":"Cappelli A, Gallelli A, Manini M, Anzini M, Mennuni L, Makovec F, Menziani MC, Alcaro S, Ortuso F, Vomero S (2005) Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties. J Med Chem 48(10):3564\u20133575. doi: 10.1021\/jm0493461","journal-title":"J Med Chem"},{"issue":"11","key":"8957_CR68","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1089\/ars.2012.4671","volume":"19","author":"E Parada","year":"2013","unstructured":"Parada E, Egea J, Buendia I, Negredo P, Cunha AC, Cardoso S, Soares MP, Lopez MG (2013) The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2. Antioxid Redox Signal 19(11):1135\u20131148. doi: 10.1089\/ars.2012.4671","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"8957_CR69","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.pnpbp.2008.11.018","volume":"33","author":"AH Rezvani","year":"2009","unstructured":"Rezvani AH, Kholdebarin E, Brucato FH, Callahan PM, Lowe DA, Levin ED (2009) Effect of R3487\/MEM3454, a novel nicotinic \u03b17 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 33(2):269\u2013275. doi: 10.1016\/j.pnpbp.2008.11.018","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"3","key":"8957_CR70","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0960-894X(00)00670-3","volume":"11","author":"JE Macor","year":"2001","unstructured":"Macor JE, Gurley D, Lanthorn T, Loch J, Mack RA, Mullen G, Tran O, Wright N, Gordon JC (2001) The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective \u03b17 nicotinic receptor partial agonist. Bioorg Med Chem Lett 11(3):319\u2013321. doi: 10.1016\/S0960-894X(00)00670-3","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"8957_CR71","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neulet.2004.12.025","volume":"378","author":"RL Papke","year":"2005","unstructured":"Papke RL, Schiff HC, Jack BA, Horenstein NA (2005) Molecular dissection of tropisetron, an \u03b17 nicotinic acetylcholine receptor-selective partial agonist. Neurosci Lett 378(3):140\u2013144. doi: 10.1016\/j.neulet.2004.12.025","journal-title":"Neurosci Lett"},{"issue":"1","key":"8957_CR72","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.coph.2011.01.010","volume":"11","author":"PA Davies","year":"2011","unstructured":"Davies PA (2011) Allosteric modulation of the 5-HT3 receptor. Curr Opin Pharmacol 11(1):75\u201380. doi: 10.1016\/j.coph.2011.01.010","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"8957_CR73","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.bcp.2005.04.031","volume":"70","author":"V Ldl","year":"2005","unstructured":"Ldl V, Mu\u00f1oz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, F\u00e4rber L, Mueller W, Stratz T, Fiebich BL (2005) The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol 70(3):369\u2013380. doi: 10.1016\/j.bcp.2005.04.031","journal-title":"Biochem Pharmacol"},{"issue":"12","key":"8957_CR74","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/j.intimp.2011.08.022","volume":"11","author":"D Setoguchi","year":"2011","unstructured":"Setoguchi D, Nakamura M, Yatsuki H, Watanabe E, Tateishi Y, Kuwaki T, Oda S (2011) Experimental examination of anti-inflammatory effects of a 5-HT3 receptor antagonist, tropisetron, and concomitant effects on autonomic nervous function in a rat sepsis model. Int Immunopharmacol 11(12):2073\u20132078. doi: 10.1016\/j.intimp.2011.08.022","journal-title":"Int Immunopharmacol"},{"key":"8957_CR75","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.brainres.2013.12.029","volume":"1551","author":"P Spilman","year":"2014","unstructured":"Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE (2014) The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer\u2019s model. Brain Res 1551:25\u201344. doi: 10.1016\/j.brainres.2013.12.029","journal-title":"Brain Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-014-8957-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-014-8957-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-014-8957-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-014-8957-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:42:12Z","timestamp":1559428932000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-014-8957-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,7]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["8957"],"URL":"https:\/\/doi.org\/10.1007\/s12035-014-8957-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,7]]}}}