{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:54:47Z","timestamp":1789008887635,"version":"build-2803163510"},"reference-count":197,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s12035-015-9123-4","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T03:32:17Z","timestamp":1424143937000},"page":"1679-1698","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer\u2019s Disease?"],"prefix":"10.1007","volume":"53","author":[{"given":"Golmaryam","family":"Sarlak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"9123_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/346245a0","volume":"346","author":"J Gubbay","year":"1990","unstructured":"Gubbay J, Collignon J, Koopman P, Capel B et al (1990) A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346:245\u2013250. doi: 10.1038\/346245a0","journal-title":"Nature"},{"key":"9123_CR2","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/346240a0","volume":"346","author":"AH Sinclair","year":"1990","unstructured":"Sinclair AH, Berta P, Palmer MS, Hawkins JR et al (1990) A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 346:240\u2013244. doi: 10.1038\/346240a0","journal-title":"Nature"},{"key":"9123_CR3","doi-asserted-by":"publisher","first-page":"7758","DOI":"10.1128\/MCB.14.12.7758","volume":"14","author":"L Dailey","year":"1994","unstructured":"Dailey L, Yuan H, Basilico C (1994) Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol 14:7758\u20137769. doi: 10.1128\/MCB.14.12.7758","journal-title":"Mol Cell Biol"},{"key":"9123_CR4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1095\/biolreprod.111.090886","volume":"85","author":"H Pan","year":"2011","unstructured":"Pan H, Schultz RM (2011) Sox2 modulates reprogramming of gene expression in two-cell mouse embryos. Biol Reprod 85:409\u2013416. doi: 10.1095\/biolreprod.111.090886","journal-title":"Biol Reprod"},{"key":"9123_CR5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1146\/annurev.cellbio.042308.113248","volume":"25","author":"S He","year":"2009","unstructured":"He S, Nakada D, Morrison SJ (2009) Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol 25:377\u2013406. doi: 10.1146\/annurev.cellbio.042308.113248","journal-title":"Annu Rev Cell Dev Biol"},{"key":"9123_CR6","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1242\/dev.01204","volume":"131","author":"ALM Ferri","year":"2004","unstructured":"Ferri ALM, Cavallaro M, Braida D, Di Cristofano A et al (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131:3805\u20133819. doi: 10.1242\/dev.01204","journal-title":"Development"},{"key":"9123_CR7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.stem.2007.09.002","volume":"1","author":"H Suh","year":"2007","unstructured":"Suh H, Consiglio A, Ray J, Sawai T et al (2007) In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell 1:515\u2013528. doi: 10.1016\/j.stem.2007.09.002","journal-title":"Cell Stem Cell"},{"key":"9123_CR8","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j. cell .2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblasts cultures by defined factors. Cell 126:663\u2013676. doi: 10.1016\/j. cell .2006.07.024","journal-title":"Cell"},{"key":"9123_CR9","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j. cell .2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M et al (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861\u2013872. doi: 10.1016\/j. cell .2007.11.019","journal-title":"Cell"},{"key":"9123_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.stem.2012.12.007","volume":"12","author":"A Sarkar","year":"2013","unstructured":"Sarkar A, Hochedlinger K (2013) The Sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell 12:15\u201330. doi: 10.1016\/j.stem.2012.12.007","journal-title":"Cell Stem Cell"},{"key":"9123_CR11","doi-asserted-by":"publisher","first-page":"e13952","DOI":"10.1371\/journal.pone.0013952","volume":"5","author":"M Keramari","year":"2010","unstructured":"Keramari M, Razavi J, Ingman KA, Patsch C et al (2010) Sox2 is essential for formation of trophectoderm in the preimplantation embryo. PLoS One 5:e13952. doi: 10.1371\/journal.pone.0013952","journal-title":"PLoS One"},{"key":"9123_CR12","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1101\/gad.224503","volume":"17","author":"AA Avilion","year":"2003","unstructured":"Avilion AA, Nicolis SK, Pevny LH, Perez L et al (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17:126\u2013140. doi: 10.1101\/gad.224503","journal-title":"Genes Dev"},{"key":"9123_CR13","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.devcel.2010.02.012","volume":"18","author":"G Guo","year":"2010","unstructured":"Guo G, Huss M, Tong GQ, Wang C et al (2010) Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell 18:675\u2013685. doi: 10.1016\/j.devcel.2010.02.012","journal-title":"Dev Cell"},{"key":"9123_CR14","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/ncb1589","volume":"9","author":"S Masui","year":"2007","unstructured":"Masui S, Nakatake Y, Toyooka Y, Shimosato D et al (2007) Pluripotency governed by Sox2 via regulation of Oct3\/4 expression in mouse embryonic stem cells. Nat Cell Biol 9:625\u2013635. doi: 10.1038\/ncb1589","journal-title":"Nat Cell Biol"},{"key":"9123_CR15","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.cell.2011.05.017","volume":"145","author":"M Thomson","year":"2011","unstructured":"Thomson M, Liu SJ, Zou LN, Smith Z et al (2011) Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 145:875\u2013889. doi: 10.1016\/j.cell.2011.05.017","journal-title":"Cell"},{"key":"9123_CR16","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S0896-6273(03)00497-5","volume":"39","author":"V Graham","year":"2003","unstructured":"Graham V, Khudyakov J, Ellis P, Pevny L (2003) SOX2 functions to maintain neural progenitor identity. Neuron 39:749\u2013765. doi: 10.1016\/S0896-6273(03)00497-5","journal-title":"Neuron"},{"key":"9123_CR17","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1634\/stemcells. 2007-0080","volume":"25","author":"HY Li","year":"2007","unstructured":"Li HY, Say EH, Zhou XF (2007) Isolation and characterization of neural crest progenitors from adult dorsal root ganglia. Stem Cells 25:2053\u20132065. doi: 10.1634\/stemcells. 2007-0080","journal-title":"Stem Cells"},{"key":"9123_CR18","doi-asserted-by":"publisher","first-page":"7939","DOI":"10.1523\/JNEUROSCI. 1203-07.2007","volume":"2730","author":"A Lagares","year":"2007","unstructured":"Lagares A, Li HY, Zhou XF, Avendano C (2007) Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation. J Neurosci 2730:7939\u20137953. doi: 10.1523\/JNEUROSCI. 1203-07.2007","journal-title":"J Neurosci"},{"key":"9123_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0896-6273(02)00827-9","volume":"35","author":"GM Kruger","year":"2002","unstructured":"Kruger GM, Mosher JT, Bixby S, Joseph N et al (2002) Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron 35:657\u2013669. doi: 10.1016\/S0896-6273(02)00827-9","journal-title":"Neuron"},{"key":"9123_CR20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.heares.2004.12.005","volume":"203","author":"H Rask-Andersen","year":"2005","unstructured":"Rask-Andersen H, Bostrom M, Gerdin B, Kinnefors A et al (2005) Regeneration of human auditory nerve. In vitro\/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion. Hear Res 203:180\u2013191. doi: 10.1016\/j.heares.2004.12.005","journal-title":"Hear Res"},{"key":"9123_CR21","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1523\/JNEUROSCI.21-18-07153.2001","volume":"21","author":"B Seri","year":"2001","unstructured":"Seri B, Garcia-Verdugo JM, McEwen BS, Alvarez-Buylla A (2001) Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci 21:7153\u20137160","journal-title":"J Neurosci"},{"key":"9123_CR22","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/glia.20407","volume":"54","author":"B Steiner","year":"2006","unstructured":"Steiner B, Klempin F, Wang L, Kott M et al (2006) Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Glia 54:805\u2013814. doi: 10.1002\/glia.20407","journal-title":"Glia"},{"key":"9123_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00441-007-0478-3","volume":"331","author":"D Ehninger","year":"2008","unstructured":"Ehninger D, Kempermann G (2008) Neurogenesis in the adult hippocampus. Cell Tissue Res 331:243\u2013250. doi: 10.1007\/s00441-007-0478-3","journal-title":"Cell Tissue Res"},{"key":"9123_CR24","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1002\/glia.20392","volume":"54","author":"X Liu","year":"2006","unstructured":"Liu X, Bolteus AJ, Balkin DM, Henschel O et al (2006) GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia 54:394\u2013410. doi: 10.1002\/glia.20392","journal-title":"Glia"},{"key":"9123_CR25","doi-asserted-by":"publisher","first-page":"6439","DOI":"10.1523\/JNEUROSCI. 0700-08","volume":"28","author":"MS Brill","year":"2008","unstructured":"Brill MS, Snapyan M, Wohlfrom H, Ninkovic J et al (2008) A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb. J Neurosci 28:6439\u20136452. doi: 10.1523\/JNEUROSCI. 0700-08","journal-title":"J Neurosci"},{"key":"9123_CR26","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1101\/gad.187336.112","volume":"26","author":"J Hsieh","year":"2012","unstructured":"Hsieh J (2012) Orchestrating transcriptional control of adult neurogenesis. Genes Dev 26:1010\u20131021. doi: 10.1101\/gad.187336.112","journal-title":"Genes Dev"},{"key":"9123_CR27","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","volume":"70","author":"GL Ming","year":"2011","unstructured":"Ming GL, Song H (2011) Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70:687\u2013702. doi: 10.1016\/j.neuron.2011.05.001","journal-title":"Neuron"},{"key":"9123_CR28","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1126\/science.271.5251.978","volume":"271","author":"C Lois","year":"1996","unstructured":"Lois C, Garcia-Verdugo JM, Alvarez-Buylla A (1996) Chain migration of neuronal precursors. Science 271:978\u2013981","journal-title":"Science"},{"key":"9123_CR29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fphys.2011.00016","volume":"2","author":"E Remboutsika","year":"2011","unstructured":"Remboutsika E, Elkouris M, Iulianella A, Andoniadou CL et al (2011) Flexibility of neural stem cells. Front Physiol 2:16. doi: 10.3389\/fphys.2011.00016","journal-title":"Front Physiol"},{"key":"9123_CR30","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.cell.2011.05.024","volume":"145","author":"MA Bonaguidi","year":"2011","unstructured":"Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP et al (2011) In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell 145:1142\u20131155. doi: 10.1016\/j.cell.2011.05.024","journal-title":"Cell"},{"key":"9123_CR31","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.stem.2011.03.011","volume":"8","author":"F Cimadamore","year":"2011","unstructured":"Cimadamore F, Fishwick K, Giusto E, Gnedeva K et al (2011) Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis. Cell Stem Cell 8:538\u2013551. doi: 10.1016\/j.stem.2011.03.011","journal-title":"Cell Stem Cell"},{"key":"9123_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ydbio.2012.01.012","volume":"366","author":"V Sasselli","year":"2012","unstructured":"Sasselli V, Pachnis V, Burns AJ (2012) The enteric nervous system. Dev Biol 366:64\u201373. doi: 10.1016\/j.ydbio.2012.01.012","journal-title":"Dev Biol"},{"key":"9123_CR33","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/stem.557","volume":"29","author":"TA Heanue","year":"2011","unstructured":"Heanue TA, Pachnis V (2011) Prospective identification and isolation of enteric nervous system progenitors using Sox2. Stem Cells 29:128\u2013140. doi: 10.1002\/stem.557","journal-title":"Stem Cells"},{"key":"9123_CR34","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.tins.2010.06.002","volume":"33","author":"MD Gershon","year":"2010","unstructured":"Gershon MD (2010) Developmental determinants of the independence and complexity of the enteric nervous system. Trends Neurosci 33:446\u2013456. doi: 10.1016\/j.tins.2010.06.002","journal-title":"Trends Neurosci"},{"key":"9123_CR35","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1242\/dev.02375","volume":"133","author":"N Bondurand","year":"2006","unstructured":"Bondurand N, Natarajan D, Barlow A, Thapar N et al (2006) Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling. Development 133:2075\u20132086. doi: 10.1242\/dev.02375","journal-title":"Development"},{"key":"9123_CR36","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1053\/j.gastro.2009.06.038","volume":"137","author":"M Metzger","year":"2009","unstructured":"Metzger M, Bareiss PM, Danker T, Wagner S et al (2009) Expansion and differentiation of neural progenitors derived from the human adult enteric nervous system. Gastroenterology 137:2063\u20132073. doi: 10.1053\/j.gastro.2009.06.038","journal-title":"Gastroenterology"},{"key":"9123_CR37","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1242\/dev.126.17.3781","volume":"126","author":"L Hagedorn","year":"1999","unstructured":"Hagedorn L, Suter U, Sommer L (1999) P0 and PMP22 mark a multipotent neural crest-derived cell type that displays community effects in response to TGF-beta family factors. Development 126:3781\u20133794","journal-title":"Development"},{"key":"9123_CR38","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1242\/dev.126.8.1715","volume":"126","author":"SE Perez","year":"1999","unstructured":"Perez SE, Rebelo S, Anderson DJ (1999) Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. Development 126:1715\u20131728","journal-title":"Development"},{"key":"9123_CR39","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nrn2057","volume":"8","author":"F Marmigere","year":"2007","unstructured":"Marmigere F, Ernfors P (2007) Specification and connectivity of neuronal subtypes in the sensory lineage. Nat Rev Neurosci 8:114\u2013127. doi: 10.1038\/nrn2057","journal-title":"Nat Rev Neurosci"},{"key":"9123_CR40","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neuron.2006.01.008","volume":"49","author":"I Kramer","year":"2006","unstructured":"Kramer I, Sigrist M, de Nooij JC, Taniuchi I et al (2006) A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron 49:379\u2013393. doi: 10.1016\/j.neuron.2006.01.008","journal-title":"Neuron"},{"key":"9123_CR41","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.stem.2011.03.013","volume":"8","author":"KM Loh","year":"2011","unstructured":"Loh KM, Lim B (2011) A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell 8:363\u2013369. doi: 10.1016\/j.stem.2011.03.013","journal-title":"Cell Stem Cell"},{"key":"9123_CR42","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.cell.2005.08.020","volume":"122","author":"LA Boyer","year":"2005","unstructured":"Boyer LA, Lee TI, Cole MF, Johnstone SE et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947\u2013956. doi: 10.1016\/j.cell.2005.08.020","journal-title":"Cell"},{"key":"9123_CR43","doi-asserted-by":"publisher","first-page":"e123","DOI":"10.1371\/journal.pcbi.0020123","volume":"2","author":"V Chickarmane","year":"2006","unstructured":"Chickarmane V, Troein C, Nuber UA, Sauro HM et al (2006) Transcriptional dynamics of the embryonic stem cell switch. PLoS Comput Biol 2:e123. doi: 10.1371\/journal.pcbi.0020123","journal-title":"PLoS Comput Biol"},{"key":"9123_CR44","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cell.2008.04.043","volume":"133","author":"X Chen","year":"2008","unstructured":"Chen X, Xu H, Yuan P, Fang F et al (2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106\u20131117. doi: 10.1016\/j.cell.2008.04.043","journal-title":"Cell"},{"key":"9123_CR45","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.cell.2008.02.039","volume":"132","author":"J Kim","year":"2008","unstructured":"Kim J, Chu J, Shen X, Wang J et al (2008) An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132:1049\u20131061. doi: 10.1016\/j.cell.2008.02.039","journal-title":"Cell"},{"key":"9123_CR46","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1634\/stemcells. 2007-0951","volume":"26","author":"JL Kopp","year":"2008","unstructured":"Kopp JL, Ormsbee BD, Desler M, Rizzino A (2008) Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells 26:903\u2013911. doi: 10.1634\/stemcells. 2007-0951","journal-title":"Stem Cells"},{"key":"9123_CR47","doi-asserted-by":"publisher","first-page":"e76345","DOI":"10.1371\/journal.pone.0076345","volume":"8","author":"BD Ormsbee Golden","year":"2013","unstructured":"Ormsbee Golden BD, Wuebben EL, Rizzino A (2013) Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1. PLoS One 8:e76345. doi: 10.1371\/journal.pone.0076345","journal-title":"PLoS One"},{"key":"9123_CR48","doi-asserted-by":"publisher","first-page":"11384","DOI":"10.1074\/jbc.M111.320143","volume":"287","author":"Z Gao","year":"2012","unstructured":"Gao Z, Cox JL, Gilmore JM, Ormsbee BD et al (2012) Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors. J Biol Chem 287:11384\u201311397. doi: 10.1074\/jbc.M111.320143","journal-title":"J Biol Chem"},{"key":"9123_CR49","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1101\/gad.1407906","volume":"20","author":"OV Taranova","year":"2006","unstructured":"Taranova OV, Magness ST, Fagan BM, Wu Y et al (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev 20:1187\u20131202. doi: 10.1101\/gad.1407906","journal-title":"Genes Dev"},{"key":"9123_CR50","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cell.2011.08.038","volume":"147","author":"YW Fong","year":"2011","unstructured":"Fong YW, Inouye C, Yamaguchi T, Cattoglio C et al (2011) A DNA repair complex functions as an Oct4\/Sox2 coactivator in embryonic stem cells. Cell 147:120\u2013131. doi: 10.1016\/j.cell.2011.08.038","journal-title":"Cell"},{"key":"9123_CR51","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/jcp.20978","volume":"211","author":"N Liu","year":"2007","unstructured":"Liu N, Lu M, Tian X, Han Z (2007) Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol 211:279\u2013286. doi: 10.1002\/jcp.20978","journal-title":"J Cell Physiol"},{"key":"9123_CR52","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nrn2189","volume":"8","author":"I Mason","year":"2007","unstructured":"Mason I (2007) Initiation to end point: the multiple roles of fibroblast growth factors in neural development. Nat Rev Neurosci 8:583\u2013596. doi: 10.1038\/nrn2189","journal-title":"Nat Rev Neurosci"},{"key":"9123_CR53","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.tcb.2011.11.004","volume":"22","author":"J Wray","year":"2012","unstructured":"Wray J, Hartmann C (2012) WNTing embryonic stem cells. Trends Cell Biol 22:159\u2013168. doi: 10.1016\/j.tcb.2011.11.004","journal-title":"Trends Cell Biol"},{"key":"9123_CR54","doi-asserted-by":"publisher","first-page":"6027","DOI":"10.1073\/pnas.0401367101","volume":"101","author":"X Qi","year":"2004","unstructured":"Qi X, Li TG, Hao J, Hu J et al (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A 101:6027\u20136032. doi: 10.1073\/pnas.0401367101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9123_CR55","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature08113","volume":"460","author":"H Niwa","year":"2009","unstructured":"Niwa H, Ogawa K, Shimosato D, Adachi K (2009) A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460:118\u2013122. doi: 10.1038\/nature08113","journal-title":"Nature"},{"key":"9123_CR56","doi-asserted-by":"publisher","first-page":"7772","DOI":"10.1128\/MCB. 00468-06","volume":"26","author":"Y Nakatake","year":"2006","unstructured":"Nakatake Y, Fukui N, Iwamatsu Y, Masui S et al (2006) Klf4 cooperates with Oct3\/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol 26:7772\u20137782. doi: 10.1128\/MCB. 00468-06","journal-title":"Mol Cell Biol"},{"key":"9123_CR57","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1152\/physrev.00030.2009","volume":"90","author":"B Ravikumar","year":"2010","unstructured":"Ravikumar B, Sarkar S, Davies JE, Futter M et al (2010) Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90:1383\u20131435. doi: 10.1152\/physrev.00030.2009","journal-title":"Physiol Rev"},{"key":"9123_CR58","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrn2474","volume":"9","author":"E Cohen","year":"2008","unstructured":"Cohen E, Dillin A (2008) The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9:759\u2013767. doi: 10.1038\/nrn2474","journal-title":"Nat Rev Neurosci"},{"key":"9123_CR59","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1089\/scd.2010.0130","volume":"20","author":"J Peltier","year":"2011","unstructured":"Peltier J, Conway A, Keung AJ, Schaffer DV (2011) Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. Stem Cells Dev 20:1153\u20131161. doi: 10.1089\/scd.2010.0130","journal-title":"Stem Cells Dev"},{"key":"9123_CR60","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1002\/stem.540","volume":"28","author":"CH Jeong","year":"2010","unstructured":"Jeong CH, Cho YY, Kim MO, Kim SH et al (2010) Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells 28:2141\u20132150. doi: 10.1002\/stem.540","journal-title":"Stem Cells"},{"key":"9123_CR61","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/ncb2293","volume":"13","author":"X Zhang","year":"2011","unstructured":"Zhang X, Yalcin S, Lee DF, Yeh TY et al (2011) FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat Cell Biol 13:1092\u20131099. doi: 10.1038\/ncb2293","journal-title":"Nat Cell Biol"},{"key":"9123_CR62","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","volume":"5","author":"JH Paik","year":"2009","unstructured":"Paik JH, Ding Z, Narurkar R, Ramkissoon S et al (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5:540\u2013553. doi: 10.1016\/j.stem.2009.09.013","journal-title":"Cell Stem Cell"},{"key":"9123_CR63","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.exger.2013.02.025","volume":"48","author":"C O\u2019Neill","year":"2013","unstructured":"O\u2019Neill C (2013) PI3-kinase\/Akt\/mTOR signaling: impaired on\/off switches in aging, cognitive decline and Alzheimer's disease. Exp Gerontol 48:647\u2013653. doi: 10.1016\/j.exger.2013.02.025","journal-title":"Exp Gerontol"},{"key":"9123_CR64","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ydbio.2005.11.011","volume":"290","author":"J Hao","year":"2006","unstructured":"Hao J, Li TG, Qi X, Zhao DF et al (2006) WNT\/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol 290:81\u201391. doi: 10.1016\/j.ydbio.2005.11.011","journal-title":"Dev Biol"},{"key":"9123_CR65","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1634\/stemcells. 2007-0177","volume":"25","author":"K Adachi","year":"2007","unstructured":"Adachi K, Mirzadeh Z, Sakaguchi M, Yamashita T et al (2007) Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone. Stem Cells 25:2827\u20132836. doi: 10.1634\/stemcells. 2007-0177","journal-title":"Stem Cells"},{"key":"9123_CR66","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/nature04108","volume":"437","author":"DC Lie","year":"2005","unstructured":"Lie DC, Colamarino SA, Song HJ, Desire L et al (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature 437:1370\u20131375. doi: 10.1038\/nature04108","journal-title":"Nature"},{"key":"9123_CR67","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1242\/jcs.080580","volume":"124","author":"YZ Wang","year":"2011","unstructured":"Wang YZ, Yamagami T, Gan Q, Wang Y et al (2011) Canonical Wnt signaling promotes the proliferation and neurogenesis of peripheral olfactory stem cells during postnatal development and adult regeneration. J Cell Sci 124:1553\u20131563. doi: 10.1242\/jcs.080580","journal-title":"J Cell Sci"},{"key":"9123_CR68","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1128\/MCB. 05798-11","volume":"31","author":"E Seo","year":"2011","unstructured":"Seo E, Basu-Roy U, Zavadil J, Basilico C et al (2011) Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Mol Cell Biol 31:4593\u20134608. doi: 10.1128\/MCB. 05798-11","journal-title":"Mol Cell Biol"},{"key":"9123_CR69","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1038\/onc.2011.405","volume":"31","author":"U Basu-Roy","year":"2012","unstructured":"Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB et al (2012) Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Oncogene 31:2270\u20132282. doi: 10.1038\/onc.2011.405","journal-title":"Oncogene"},{"key":"9123_CR70","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1242\/dev.040451","volume":"136","author":"M Agathocleous","year":"2009","unstructured":"Agathocleous M, Iordanova I, Willardsen MI, Xue XY et al (2009) A directional Wnt\/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. Development 136:3289\u20133299. doi: 10.1242\/dev.040451","journal-title":"Development"},{"key":"9123_CR71","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/nn.2360","volume":"12","author":"T Kuwabara","year":"2009","unstructured":"Kuwabara T, Hsieh J, Muotri A, Yeo G et al (2009) Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci 12:1097\u20131105. doi: 10.1038\/nn.2360","journal-title":"Nat Neurosci"},{"key":"9123_CR72","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1083\/jcb.200409182","volume":"168","author":"A Mansukhani","year":"2005","unstructured":"Mansukhani A, Ambrosetti D, Holmes G, Cornivelli L et al (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol 168:1065\u20131076. doi: 10.1083\/jcb.200409182","journal-title":"J Cell Biol"},{"key":"9123_CR73","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fnins.2011.00078","volume":"5","author":"H Shimojo","year":"2011","unstructured":"Shimojo H, Ohtsuka T, Kageyama R (2011) Dynamic expression of notch signaling genes in neural stem\/progenitor cells. Front Neurosci 5:78. doi: 10.3389\/fnins.2011.00078","journal-title":"Front Neurosci"},{"key":"9123_CR74","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12035-011-8186-0","volume":"44","author":"I Imayoshi","year":"2011","unstructured":"Imayoshi I, Kageyama R (2011) The role of Notch signaling in adult neurogenesis. Mol Neurobiol 44:7\u201312. doi: 10.1007\/s12035-011-8186-0","journal-title":"Mol Neurobiol"},{"key":"9123_CR75","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000090755","volume":"28","author":"MI Givogri","year":"2006","unstructured":"Givogri MI, de Planell M, Galbiati F, Superchi D et al (2006) Notch signaling in astrocytes and neuroblasts of the adult subventricular zone in health and after cortical injury. Dev Neurosci 28:81\u201391. doi: 10.1159\/000090755","journal-title":"Dev Neurosci"},{"key":"9123_CR76","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1111\/acel.12134","volume":"12","author":"F Sun","year":"2013","unstructured":"Sun F, Mao X, Xie L, Ding M et al (2013) Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia. Aging Cell 12:978\u2013987. doi: 10.1111\/acel.12134","journal-title":"Aging Cell"},{"key":"9123_CR77","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1111\/j.1460-9568.2006.04766.x","volume":"23","author":"M Guentchev","year":"2006","unstructured":"Guentchev M, McKay RD (2006) Notch controls proliferation and differentiation of stem cells in a dose-dependent manner. Eur J Neurosci 23:2289\u20132296. doi: 10.1111\/j.1460-9568.2006.04766.x","journal-title":"Eur J Neurosci"},{"key":"9123_CR78","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1242\/dev.060657","volume":"138","author":"J Neves","year":"2011","unstructured":"Neves J, Parada C, Chamizo M, Giraldez F (2011) Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification. Development 138:735\u2013744. doi: 10.1242\/dev.060657","journal-title":"Development"},{"key":"9123_CR79","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1093\/nar\/gkf435","volume":"30","author":"M Tomioka","year":"2002","unstructured":"Tomioka M, Nishimoto M, Miyagi S, Katayanagi T et al (2002) Identification of Sox-2 regulatory region which is under the control of Oct-3\/4-Sox-2 complex. Nucleic Acids Res 30:3202\u20133213. doi: 10.1093\/nar\/gkf435","journal-title":"Nucleic Acids Res"},{"key":"9123_CR80","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.1128\/MCB. 24.10.4207-4220.2004","volume":"24","author":"S Miyagi","year":"2004","unstructured":"Miyagi S, Saito T, Mizutani K, Masuyama N et al (2004) The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells. Mol Cell Biol 24:4207\u20134220. doi: 10.1128\/MCB. 24.10.4207-4220.2004","journal-title":"Mol Cell Biol"},{"key":"9123_CR81","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1002\/jnr.21635","volume":"86","author":"M Sikorska","year":"2008","unstructured":"Sikorska M, Sandhu JK, Deb-Rinker P, Jezierski A et al (2008) Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation. J Neurosci Res 86:1680\u20131693. doi: 10.1002\/jnr.21635","journal-title":"J Neurosci Res"},{"key":"9123_CR82","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.stem.2012.09.014","volume":"11","author":"H Li","year":"2012","unstructured":"Li H, Collado M, Villasante A, Matheu A et al (2012) p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation. Cell Stem Cell 11:845\u2013852. doi: 10.1016\/j.stem.2012.09.014","journal-title":"Cell Stem Cell"},{"key":"9123_CR83","doi-asserted-by":"publisher","first-page":"e1003288","DOI":"10.1371\/journal.pgen.1003288","volume":"9","author":"MA Lodato","year":"2013","unstructured":"Lodato MA, Ng CW, Wamstad JA, Cheng AW et al (2013) SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet 9:e1003288. doi: 10.1371\/journal.pgen.1003288","journal-title":"PLoS Genet"},{"key":"9123_CR84","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrg2485","volume":"10","author":"M Haberland","year":"2009","unstructured":"Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10:32\u201342. doi: 10.1038\/nrg2485","journal-title":"Nat Rev Genet"},{"key":"9123_CR85","doi-asserted-by":"publisher","first-page":"e15486","DOI":"10.1371\/journal.pone.0015486","volume":"5","author":"JL Cox","year":"2010","unstructured":"Cox JL, Mallanna SK, Luo X, Rizzino A (2010) Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes. PLoS One 5:e15486. doi: 10.1371\/journal.pone.0015486","journal-title":"PLoS One"},{"key":"9123_CR86","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1093\/nar\/gkr1151","volume":"40","author":"BL Kidder","year":"2012","unstructured":"Kidder BL, Palmer S (2012) HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells. Nucleic Acids Res 40:2925\u20132939. doi: 10.1093\/nar\/gkr1151","journal-title":"Nucleic Acids Res"},{"key":"9123_CR87","doi-asserted-by":"publisher","first-page":"6998","DOI":"10.1074\/jbc.M807670200","volume":"284","author":"GA Baltus","year":"2009","unstructured":"Baltus GA, Kowalski MP, Tutter AV, Kadam S (2009) A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2. J Biol Chem 284:6998\u20137006. doi: 10.1074\/jbc.M807670200","journal-title":"J Biol Chem"},{"key":"9123_CR88","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1128\/MCB. 25.6.2475-2485.2005","volume":"25","author":"T Kuroda","year":"2005","unstructured":"Kuroda T, Tada M, Kubota H, Kimura H et al (2005) Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol 25:2475\u20132485. doi: 10.1128\/MCB. 25.6.2475-2485.2005","journal-title":"Mol Cell Biol"},{"key":"9123_CR89","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0092-8674(03)00393-3","volume":"113","author":"K Mitsui","year":"2003","unstructured":"Mitsui K, Tokuzawa Y, Itoh H, Segawa K et al (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631\u2013642. doi: 10.1016\/S0092-8674(03)00393-3","journal-title":"Cell"},{"key":"9123_CR90","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/nn.2672","volume":"13","author":"DK Ma","year":"2010","unstructured":"Ma DK, Marchetto MC, Guo JU, Ming GL et al (2010) Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci 13:1338\u20131344. doi: 10.1038\/nn.2672","journal-title":"Nat Neurosci"},{"key":"9123_CR91","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nrm3230","volume":"12","author":"B Schuettengruber","year":"2011","unstructured":"Schuettengruber B, Martinez AM, Iovino N, Cavalli G (2011) Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol 12:799\u2013814. doi: 10.1038\/nrm3230","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9123_CR92","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.cell.2006.02.043","volume":"125","author":"TI Lee","year":"2006","unstructured":"Lee TI, Jenner RG, Boyer LA, Guenther MG et al (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125:301\u2013313. doi: 10.1016\/j.cell.2006.02.043","journal-title":"Cell"},{"key":"9123_CR93","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nrg2046","volume":"8","author":"M Spivakov","year":"2007","unstructured":"Spivakov M, Fisher AG (2007) Epigenetic signatures of stem-cell identity. Nat Rev Genet 8:263\u2013271. doi: 10.1038\/nrg2046","journal-title":"Nat Rev Genet"},{"key":"9123_CR94","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1038\/onc.2011.45","volume":"30","author":"EA Pollina","year":"2011","unstructured":"Pollina EA, Brunet A (2011) Epigenetic regulation of aging stem cells. Oncogene 30:3105\u20133126. doi: 10.1038\/onc.2011.45","journal-title":"Oncogene"},{"key":"9123_CR95","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.stem.2007.04.001","volume":"1","author":"CA Fasano","year":"2007","unstructured":"Fasano CA, Dimos JT, Ivanova NB, Lowry N et al (2007) shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell 1:87\u201399. doi: 10.1016\/j.stem.2007.04.001","journal-title":"Cell Stem Cell"},{"key":"9123_CR96","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ydbio.2009.01.020","volume":"328","author":"S He","year":"2009","unstructured":"He S, Iwashita T, Buchstaller J, Molofsky AV et al (2009) Bmi-1 over-expression in neural stem\/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol 328:257\u2013272. doi: 10.1016\/j.ydbio.2009.01.020","journal-title":"Dev Biol"},{"key":"9123_CR97","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1101\/gad.1299505","volume":"19","author":"AV Molofsky","year":"2005","unstructured":"Molofsky AV, He S, Bydon M, Morrison SJ et al (2005) Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19:1432\u20131437. doi: 10.1101\/gad.1299505","journal-title":"Genes Dev"},{"key":"9123_CR98","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1101\/gad.1299305","volume":"19","author":"SW Bruggeman","year":"2005","unstructured":"Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ et al (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19:1438\u20131443. doi: 10.1101\/gad.1299305","journal-title":"Genes Dev"},{"key":"9123_CR99","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrm2868","volume":"11","author":"M Inui","year":"2010","unstructured":"Inui M, Martello G, Piccolo S (2010) MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11:252\u2013263. doi: 10.1038\/nrm2868","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9123_CR100","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.cell.2009.02.038","volume":"137","author":"N Xu","year":"2009","unstructured":"Xu N, Papagiannakopoulos T, Pan G, Thomson JA et al (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137:647\u2013658. doi: 10.1016\/j.cell.2009.02.038","journal-title":"Cell"},{"key":"9123_CR101","doi-asserted-by":"publisher","first-page":"6426","DOI":"10.1128\/MCB. 00359-08","volume":"28","author":"DA Card","year":"2008","unstructured":"Card DA, Hebbar PB, Li L, Trotter KW et al (2008) Oct4\/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol 28:6426\u20136438. doi: 10.1128\/MCB. 00359-08","journal-title":"Mol Cell Biol"},{"key":"9123_CR102","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1128\/MCB. 00398-08","volume":"28","author":"A Barroso-delJesus","year":"2008","unstructured":"Barroso-delJesus A, Romero-Lopez C, Lucena-Aguilar G, Melen GJ et al (2008) Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. Mol Cell Biol 28:6609\u20136619. doi: 10.1128\/MCB. 00398-08","journal-title":"Mol Cell Biol"},{"key":"9123_CR103","doi-asserted-by":"publisher","first-page":"e16617","DOI":"10.1371\/journal.pone.0016617","volume":"6","author":"T Otsubo","year":"2011","unstructured":"Otsubo T, Akiyama Y, Hashimoto Y, Shimada S et al (2011) MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One 6:e16617. doi: 10.1371\/journal.pone.0016617","journal-title":"PLoS One"},{"key":"9123_CR104","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/nature07299","volume":"455","author":"Y Tay","year":"2008","unstructured":"Tay Y, Zhang J, Thomson AM, Lim B et al (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455:1124\u20131128. doi: 10.1038\/nature07299","journal-title":"Nature"},{"key":"9123_CR105","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1083\/jcb.200908151","volume":"189","author":"KE Szulwach","year":"2010","unstructured":"Szulwach KE, Li X, Smrt RD, Li Y et al (2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 189:127\u2013141. doi: 10.1083\/jcb.200908151","journal-title":"J Cell Biol"},{"key":"9123_CR106","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.135.3509.1127","volume":"135","author":"J Altman","year":"1962","unstructured":"Altman J (1962) Are new neurons formed in the brain of adult mammals? Science 135:1127\u20131128","journal-title":"Science"},{"key":"9123_CR107","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","volume":"124","author":"J Altman","year":"1965","unstructured":"Altman J, Das GD (1965) Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124:319\u2013335","journal-title":"J Comp Neurol"},{"key":"9123_CR108","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.cell.2014.02.029","volume":"156","author":"KC Vadodaria","year":"2014","unstructured":"Vadodaria KC, Gage FH (2014) Snapshot: Adult hippocampal neurogenesis. Cell 156:1114. doi: 10.1016\/j.cell.2014.02.029","journal-title":"Cell"},{"key":"9123_CR109","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.neuron.2013.10.037","volume":"80","author":"FH Gage","year":"2013","unstructured":"Gage FH, Temple S (2013) Neural stem cells: generating and regenerating the brain. Neuron 80:588\u2013601. doi: 10.1016\/j.neuron.2013.10.037","journal-title":"Neuron"},{"key":"9123_CR110","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0197-4580(03)00083-6","volume":"25","author":"L Bondolfi","year":"2004","unstructured":"Bondolfi L, Ermini F, Long JM, Ingram DK et al (2004) Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL\/6 mice. Neurobiol Aging 25:333\u2013340. doi: 10.1016\/S0197-4580(03)00083-6","journal-title":"Neurobiol Aging"},{"key":"9123_CR111","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neulet.2005.05.022","volume":"385","author":"HY McDonald","year":"2005","unstructured":"McDonald HY, Wojtowicz JM (2005) Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci Lett 385:70\u201375. doi: 10.1016\/j.neulet.2005.05.022","journal-title":"Neurosci Lett"},{"key":"9123_CR112","doi-asserted-by":"publisher","first-page":"17169","DOI":"10.1073\/pnas.0708228104","volume":"104","author":"B Leuner","year":"2007","unstructured":"Leuner B, Kozorovitskiy Y, Gross CG, Gould E (2007) Diminished adult neurogenesis in the marmoset brain precedes old age. Proc Natl Acad Sci U S A 104:17169\u201317173. doi: 10.1073\/pnas.0708228104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9123_CR113","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neurobiolaging.2006.09.015","volume":"29","author":"B Hattiangady","year":"2008","unstructured":"Hattiangady B, Shetty AK (2008) Aging does not alter the number or phenotype of putative stem\/progenitor cells in the neurogenic region of the hippocampus. Neurobiol Aging 29:129\u2013147. doi: 10.1016\/j.neurobiolaging.2006.09.015","journal-title":"Neurobiol Aging"},{"key":"9123_CR114","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrm2241","volume":"8","author":"NE Sharpless","year":"2007","unstructured":"Sharpless NE, DePinho RA (2007) How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8:703\u2013713. doi: 10.1038\/nrm2241","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9123_CR115","doi-asserted-by":"publisher","first-page":"14394","DOI":"10.1523\/JNEUROSCI. 3836-09.2009","volume":"29","author":"SR Ferron","year":"2009","unstructured":"Ferron SR, Marques-Torrejon MA, Mira H, Flores I et al (2009) Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci 29:14394\u201314407. doi: 10.1523\/JNEUROSCI. 3836-09.2009","journal-title":"J Neurosci"},{"key":"9123_CR116","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.stem.2011.03.010","volume":"8","author":"JM Encinas","year":"2011","unstructured":"Encinas JM, Michurina TV, Peunova N, Park JH et al (2011) Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell 8:566\u2013579. doi: 10.1016\/j.stem.2011.03.010","journal-title":"Cell Stem Cell"},{"key":"9123_CR117","doi-asserted-by":"crossref","first-page":"176","DOI":"10.18632\/aging.100446","volume":"4","author":"B Artegiani","year":"2012","unstructured":"Artegiani B, Calegari F (2012) Age-related cognitive decline: can neural stem cells help us? Aging 4:176\u2013186","journal-title":"Aging"},{"key":"9123_CR118","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1182\/blood-2007-05-087759","volume":"110","author":"YY Jang","year":"2007","unstructured":"Jang YY, Sharkis SJ (2007) A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 110:3056\u20133063. doi: 10.1182\/blood-2007-05-087759","journal-title":"Blood"},{"key":"9123_CR119","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","volume":"8","author":"JE Belle Le","year":"2011","unstructured":"Le Belle JE, Orozco NM, Paucar AA, Saxe JP et al (2011) Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner. Cell Stem Cell 8:59\u201371. doi: 10.1016\/j.stem.2010.11.028","journal-title":"Cell Stem Cell"},{"key":"9123_CR120","doi-asserted-by":"publisher","first-page":"e35264","DOI":"10.1371\/journal.pone.0035264","volume":"7","author":"NM Walton","year":"2012","unstructured":"Walton NM, Shin R, Tajinda K, Heusner CL et al (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One 7:e35264. doi: 10.1371\/journal.pone.0035264","journal-title":"PLoS One"},{"key":"9123_CR121","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1158\/1541-7786.MCR-08-0360","volume":"7","author":"AM McCord","year":"2009","unstructured":"McCord AM, Jamal M, Shankavaram UT, Lang FF et al (2009) Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro. Mol Cancer Res 7:489\u2013497. doi: 10.1158\/1541-7786.MCR-08-0360","journal-title":"Mol Cancer Res"},{"key":"9123_CR122","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1242\/dev.091777","volume":"140","author":"N Shyh-Chang","year":"2013","unstructured":"Shyh-Chang N, Daley GQ, Cantley LC (2013) Stem cell metabolism in tissue development and aging. Development 140:2535\u20132547. doi: 10.1242\/dev.091777","journal-title":"Development"},{"key":"9123_CR123","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1016\/j.bbamcr.2011.04.003","volume":"1813","author":"DE Kloet","year":"2011","unstructured":"Kloet DE, Burgering BM (2011) The PKB\/FOXO switch in aging and cancer. Biochim Biophys Acta 1813:1926\u20131937. doi: 10.1016\/j.bbamcr.2011.04.003","journal-title":"Biochim Biophys Acta"},{"key":"9123_CR124","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1002\/bies.10191","volume":"24","author":"JJ Tyson","year":"2002","unstructured":"Tyson JJ, Csikasz-Nagy A, Novak B (2002) The dynamics of cell cycle regulation. BioEssays 24:1095\u20131109. doi: 10.1002\/bies.10191","journal-title":"BioEssays"},{"key":"9123_CR125","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.biocel.2004.10.013","volume":"37","author":"I Ben-Porath","year":"2005","unstructured":"Ben-Porath I, Weinberg RA (2005) The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37:961\u2013976. doi: 10.1016\/j.biocel.2004.10.013","journal-title":"Int J Biochem Cell Biol"},{"key":"9123_CR126","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrm2233","volume":"8","author":"J Campisi","year":"2007","unstructured":"Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729\u2013740. doi: 10.1038\/nrm2233","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9123_CR127","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tig.2011.12.002","volume":"28","author":"HC Reinhardt","year":"2012","unstructured":"Reinhardt HC, Schumacher B (2012) The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet 28:128\u2013136. doi: 10.1016\/j.tig.2011.12.002","journal-title":"Trends Genet"},{"key":"9123_CR128","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1242\/dev.02208","volume":"133","author":"K Meletis","year":"2006","unstructured":"Meletis K, Wirta V, Hede SM, Nister M et al (2006) p53 suppresses the self-renewal of adult neural stem cells. Development 133:363\u2013369. doi: 10.1242\/dev.02208","journal-title":"Development"},{"key":"9123_CR129","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.stem.2012.12.001","volume":"12","author":"MA Marques-Torrejon","year":"2013","unstructured":"Marques-Torrejon MA, Porlan E, Banito A, Gomez-Ibarlucea E et al (2013) Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression. Cell Stem Cell 12:88\u2013100. doi: 10.1016\/j.stem.2012.12.001","journal-title":"Cell Stem Cell"},{"key":"9123_CR130","doi-asserted-by":"publisher","first-page":"15406","DOI":"10.1073\/pnas.95.26.15406","volume":"95","author":"DM Li","year":"1998","unstructured":"Li DM, Sun H (1998) PTEN\/MMAC1\/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci U S A 95:15406\u201315411. doi: 10.1073\/pnas.95.26.15406","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9123_CR131","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI22475","volume":"114","author":"J Krishnamurthy","year":"2004","unstructured":"Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI et al (2004) Ink4a\/Arf expression is a biomarker of aging. J Clin Invest 114:1299\u20131307. doi: 10.1172\/JCI22475","journal-title":"J Clin Invest"},{"key":"9123_CR132","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nature05091","volume":"443","author":"AV Molofsky","year":"2006","unstructured":"Molofsky AV, Slutsky SG, Joseph NM, He S et al (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443:448\u2013452. doi: 10.1038\/nature05091","journal-title":"Nature"},{"key":"9123_CR133","doi-asserted-by":"publisher","first-page":"e31870","DOI":"10.1371\/journal.pone.0031870","volume":"7","author":"M Abdouh","year":"2012","unstructured":"Abdouh M, Chatoo W, El Hajjar J, David J et al (2012) Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons. Plos One 7:e31870. doi: 10.1371\/journal.pone.0031870","journal-title":"Plos One"},{"key":"9123_CR134","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/nature08290","volume":"460","author":"H Li","year":"2009","unstructured":"Li H, Collado M, Villasante A, Strati K et al (2009) The Ink4\/Arf locus is a barrier for iPS cell reprogramming. Nature 460:1136\u20131139. doi: 10.1038\/nature08290","journal-title":"Nature"},{"key":"9123_CR135","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/ng.465","volume":"41","author":"AJ Bass","year":"2009","unstructured":"Bass AJ, Watanabe H, Mermel CH, Yu S et al (2009) SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 41:1238\u20131242. doi: 10.1038\/ng.465","journal-title":"Nat Genet"},{"key":"9123_CR136","doi-asserted-by":"publisher","first-page":"e8960","DOI":"10.1371\/journal.pone.0008960","volume":"5","author":"T Hussenet","year":"2010","unstructured":"Hussenet T, Dali S, Exinger J, Monga B et al (2010) SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS One 5:e8960. doi: 10.1371\/journal.pone.0008960","journal-title":"PLoS One"},{"key":"9123_CR137","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.stem.2012.05.018","volume":"11","author":"KL Ring","year":"2012","unstructured":"Ring KL, Tong LM, Balestra ME, Javier R et al (2012) Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 11:100\u2013109. doi: 10.1016\/j.stem.2012.05.018","journal-title":"Cell Stem Cell"},{"key":"9123_CR138","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","volume":"462","author":"I Kim","year":"2007","unstructured":"Kim I, Rodriguez-Enriquez S, Lemasters JJ (2007) Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462:245\u2013253. doi: 10.1016\/j.abb.2007.03.034","journal-title":"Arch Biochem Biophys"},{"key":"9123_CR139","doi-asserted-by":"publisher","first-page":"e57172","DOI":"10.1371\/journal.pone.0057172","volume":"8","author":"YY Cho","year":"2013","unstructured":"Cho YY, Kim DJ, Lee HS, Jeong CH et al (2013) Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PLoS One 8:e57172. doi: 10.1371\/journal.pone.0057172","journal-title":"PLoS One"},{"key":"9123_CR140","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/j.1474-9726.2012.00816.x","volume":"11","author":"CJ Miranda","year":"2012","unstructured":"Miranda CJ, Braun L, Jiang Y, Hester ME et al (2012) Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Aging Cell 11:542\u2013552. doi: 10.1111\/j.1474-9726.2012.00816.x","journal-title":"Aging Cell"},{"key":"9123_CR141","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nature12631","volume":"503","author":"MC Florian","year":"2013","unstructured":"Florian MC, Nattamai KJ, Dorr K, Marka G et al (2013) A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature 503:392\u2013396. doi: 10.1038\/nature12631","journal-title":"Nature"},{"key":"9123_CR142","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.1096\/fj.11-184697","volume":"25","author":"M Okamoto","year":"2011","unstructured":"Okamoto M, Inoue K, Iwamura H, Terashima K et al (2011) Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis. FASEB J 25:3570\u20133582. doi: 10.1096\/fj.11-184697","journal-title":"FASEB J"},{"key":"9123_CR143","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.mad.2010.03.008","volume":"131","author":"G St Laurent 3rd","year":"2010","unstructured":"St Laurent G 3rd, Hammell N, McCaffrey TA (2010) A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev 131:299\u2013305. doi: 10.1016\/j.mad.2010.03.008","journal-title":"Mech Ageing Dev"},{"key":"9123_CR144","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/nature08248","volume":"460","author":"NG Coufal","year":"2009","unstructured":"Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW et al (2009) L1 retrotransposition in human neural progenitor cells. Nature 460:1127\u20131131. doi: 10.1038\/nature08248","journal-title":"Nature"},{"key":"9123_CR145","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.jmb.2006.01.089","volume":"357","author":"SL Gasior","year":"2006","unstructured":"Gasior SL, Wakeman TP, Xu B, Deininger PL (2006) The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol 357:1383\u20131393. doi: 10.1016\/j.jmb.2006.01.089","journal-title":"J Mol Biol"},{"key":"9123_CR146","doi-asserted-by":"publisher","first-page":"20376","DOI":"10.1073\/pnas.1100271108","volume":"108","author":"PH Maxwell","year":"2011","unstructured":"Maxwell PH, Burhans WC, Curcio MJ (2011) Retrotransposition is associated with genome instability during chronological aging. Proc Natl Acad Sci U S A 108:20376\u201320381. doi: 10.1073\/pnas.1100271108","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9123_CR147","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.gene.2008.04.013","volume":"419","author":"NA Wallace","year":"2008","unstructured":"Wallace NA, Belancio VP, Deininger PL (2008) L1 mobile element expression causes multiple types of toxicity. Gene 419:75\u201381. doi: 10.1016\/j.gene.2008.04.013","journal-title":"Gene"},{"key":"9123_CR148","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1152\/physrev.00023.2009","volume":"90","author":"B Strooper De","year":"2010","unstructured":"De Strooper B (2010) Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol Rev 90:465\u2013494. doi: 10.1152\/physrev.00023.2009","journal-title":"Physiol Rev"},{"key":"9123_CR149","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.tips.2013.01.008","volume":"34","author":"H Wang","year":"2013","unstructured":"Wang H, Li R, Shen Y (2013) \u03b2-secretase: its biology as a therapeutic target in diseases. Trends Pharmacol Sci 34:215\u2013225. doi: 10.1016\/j.tips.2013.01.008","journal-title":"Trends Pharmacol Sci"},{"key":"9123_CR150","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.semcdb.2008.12.011","volume":"20","author":"MS Wolfe","year":"2009","unstructured":"Wolfe MS (2009) \u03b3-secretase in biology and medicine. Semin Cell Dev Biol 20:219\u2013224. doi: 10.1016\/j.semcdb.2008.12.011","journal-title":"Semin Cell Dev Biol"},{"key":"9123_CR151","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2174\/156720512799361646","volume":"9","author":"B Vincent","year":"2012","unstructured":"Vincent B, Checler F (2012) \u03b1-secretase in Alzheimer\u2019s disease and beyond: mechanistic, regulation and function in the shedding of membrane proteins. Curr Alzheimer Res 9:140\u2013156. doi: 10.2174\/156720512799361646","journal-title":"Curr Alzheimer Res"},{"key":"9123_CR152","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1073\/pnas.2634794100","volume":"101","author":"K Jin","year":"2004","unstructured":"Jin K, Peel AL, Mao XO, Xie L et al (2004) Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci U S A 101:343\u2013347. doi: 10.1073\/pnas.2634794100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9123_CR153","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/nrn2822","volume":"11","author":"W Deng","year":"2010","unstructured":"Deng W, Aimone JB, Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11:339\u2013350. doi: 10.1038\/nrn2822","journal-title":"Nat Rev Neurosci"},{"key":"9123_CR154","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2152\/jmi.53.61","volume":"53","author":"Q Wang","year":"2006","unstructured":"Wang Q, Matsumoto Y, Shindo T, Miyake K et al (2006) Neural stem cells transplantation in cortex in a mouse model of Alzheimer's disease. J Med Investig 53:61\u201369. doi: 10.2152\/jmi.53.61","journal-title":"J Med Investig"},{"key":"9123_CR155","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000124979","volume":"75","author":"S Wu","year":"2008","unstructured":"Wu S, Sasaki A, Yoshimoto R, Kawahara Y et al (2008) Neural stem cells improve learning and memory in rats with Alzheimer's disease. Pathobiology 75:186\u2013194. doi: 10.1159\/000124979","journal-title":"Pathobiology"},{"key":"9123_CR156","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.diff.2009.06.005","volume":"78","author":"FH Moghadam","year":"2009","unstructured":"Moghadam FH, Alaie H, Karbalaie K, Tanhaei S et al (2009) Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats. Differentiation 78:59\u201368. doi: 10.1016\/j.diff.2009.06.005","journal-title":"Differentiation"},{"key":"9123_CR157","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.expneurol.2011.12.040","volume":"234","author":"D Park","year":"2012","unstructured":"Park D, Lee HJ, Joo SS, Bae DK et al (2012) Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction. Exp Neurol 234:521\u2013526. doi: 10.1016\/j.expneurol.2011.12.040","journal-title":"Exp Neurol"},{"key":"9123_CR158","doi-asserted-by":"publisher","first-page":"R35","DOI":"10.1093\/hmg\/ddu302","volume":"23","author":"FJ Livesey","year":"2014","unstructured":"Livesey FJ (2014) Human stem cell models of dementia. Hum Mol Genet 23:R35\u2013R39. doi: 10.1093\/hmg\/ddu302","journal-title":"Hum Mol Genet"},{"key":"9123_CR159","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/cne.20840","volume":"495","author":"MH Donovan","year":"2006","unstructured":"Donovan MH, Yazdani U, Norris RD, Games D et al (2006) Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease. J Comp Neurol 495:70\u201383197. doi: 10.1002\/cne.20840","journal-title":"J Comp Neurol"},{"key":"9123_CR160","doi-asserted-by":"publisher","first-page":"e2935198","DOI":"10.1371\/journal.pone.0002935","volume":"3","author":"JJ Rodriguez","year":"2008","unstructured":"Rodriguez JJ, Jones VC, Tabuchi M, Allan SM et al (2008) Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS One 3:e2935198. doi: 10.1371\/journal.pone.0002935","journal-title":"PLoS One"},{"key":"9123_CR161","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.brainres.2012.02.015","volume":"1449","author":"A Hamilton","year":"2012","unstructured":"Hamilton A, Holscher C (2012) The effect of ageing on neurogenesis and oxidative stress in the APP(swe)\/PS1(deltaE9) mouse model of Alzheimer's disease. Brain Res 1449:83\u201393. doi: 10.1016\/j.brainres.2012.02.015","journal-title":"Brain Res"},{"key":"9123_CR162","doi-asserted-by":"publisher","first-page":"24264","DOI":"10.1074\/jbc.M111.227421","volume":"286","author":"KK Freude","year":"2011","unstructured":"Freude KK, Penjwini M, Davis JL, LaFerla FM et al (2011) Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem 286:24264\u201324274. doi: 10.1074\/jbc.M111.227421","journal-title":"J Biol Chem"},{"key":"9123_CR163","doi-asserted-by":"publisher","first-page":"10431","DOI":"10.1523\/JNEUROSCI. 1445-10.2010","volume":"30","author":"TL Young-Pearse","year":"2010","unstructured":"Young-Pearse TL, Suth S, Luth ES, Sawa A et al (2010) Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci 30:10431\u201310440. doi: 10.1523\/JNEUROSCI. 1445-10.2010","journal-title":"J Neurosci"},{"key":"9123_CR164","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1242\/jcs.122440","volume":"126","author":"SA Shariati","year":"2013","unstructured":"Shariati SA, Lau P, Hassan BA, Muller U et al (2013) APLP2 regulates neuronal stem cell differentiation during cortical development. J Cell Sci 126:1268\u20131277. doi: 10.1242\/jcs.122440","journal-title":"J Cell Sci"},{"key":"9123_CR165","doi-asserted-by":"publisher","first-page":"23806","DOI":"10.1074\/jbc.M109.026328","volume":"284","author":"P Porayette","year":"2009","unstructured":"Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL et al (2009) Differential processing of amyloid-\u03b2 precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. J Biol Chem 284:23806\u201323817. doi: 10.1074\/jbc.M109.026328","journal-title":"J Biol Chem"},{"key":"9123_CR166","doi-asserted-by":"publisher","first-page":"5439","DOI":"10.1523\/JNEUROSCI. 0974-04.2004","volume":"24","author":"MA Lopez-Toledano","year":"2004","unstructured":"Lopez-Toledano MA, Shelanski ML (2004) Neurogenic effects of \u03b2-amyloid peptide in the development of neural stem cells. J Neurosci 24:5439\u20135444. doi: 10.1523\/JNEUROSCI. 0974-04.2004","journal-title":"J Neurosci"},{"key":"9123_CR167","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.expneurol.2006.09.018","volume":"204","author":"C Zhang","year":"2007","unstructured":"Zhang C, McNeil E, Dressler L, Siman R (2007) Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Exp Neurol 204:77\u201387. doi: 10.1016\/j.expneurol.2006.09.018","journal-title":"Exp Neurol"},{"key":"9123_CR168","doi-asserted-by":"publisher","first-page":"6545","DOI":"10.1523\/JNEUROSCI. 0421-09.2009","volume":"29","author":"P He","year":"2009","unstructured":"He P, Shen Y (2009) Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci 29:6545\u20136557. doi: 10.1523\/JNEUROSCI. 0421-09.2009","journal-title":"J Neurosci"},{"key":"9123_CR169","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1242\/dev.01103","volume":"131","author":"I Caille","year":"2004","unstructured":"Caille I, Allinquant B, Dupont E, Bouillot C et al (2004) Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131:2173\u20132181. doi: 10.1242\/dev.01103","journal-title":"Development"},{"key":"9123_CR170","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1002\/hipo.20988","volume":"22","author":"S Baratchi","year":"2012","unstructured":"Baratchi S, Evans J, Tate WP, Abraham WC et al (2012) Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus 22:1517\u20131527. doi: 10.1002\/hipo.20988","journal-title":"Hippocampus"},{"key":"9123_CR171","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1111\/j.1460-9568.2008.06398.x","volume":"28","author":"N Gakhar-Koppole","year":"2008","unstructured":"Gakhar-Koppole N, Hundeshagen P, Mandl C, Weyer SW et al (2008) Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. Eur J Neurosci 28:871\u2013882. doi: 10.1111\/j.1460-9568.2008.06398.x","journal-title":"Eur J Neurosci"},{"key":"9123_CR172","doi-asserted-by":"publisher","first-page":"e11866","DOI":"10.1371\/journal.pone.0011866","volume":"5","author":"K Ghosal","year":"2010","unstructured":"Ghosal K, Stathopoulos A, Pimplikar SW (2010) APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. PLoS One 5:e11866. doi: 10.1371\/journal.pone.0011866","journal-title":"PLoS One"},{"key":"9123_CR173","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/WAD.0b013e3182163b62","volume":"26","author":"LG Apostolova","year":"2012","unstructured":"Apostolova LG, Green AE, Babakchanian S, Hwang KS et al (2012) Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease. Alzheimer Dis Assoc Disord 26:17\u201327. doi: 10.1097\/WAD.0b013e3182163b62","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"9123_CR174","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.celrep.2013.06.005","volume":"4","author":"X Hu","year":"2013","unstructured":"Hu X, He W, Luo X, Tsubota KE et al (2013) BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway. Cell Rep 4:40\u201349. doi: 10.1016\/j.celrep.2013.06.005","journal-title":"Cell Rep"},{"key":"9123_CR175","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.neuroscience.2004.03.048","volume":"126","author":"R Wang","year":"2004","unstructured":"Wang R, Dineley KT, Sweatt JD, Zheng H (2004) Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience 126:305\u2013312. doi: 10.1016\/j.neuroscience.2004.03.048","journal-title":"Neuroscience"},{"key":"9123_CR176","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.expneurol.2004.04.002","volume":"188","author":"PH Wen","year":"2004","unstructured":"Wen PH, Hof PR, Chen X, Gluck K et al (2004) The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol 188:224\u2013237. doi: 10.1016\/j.expneurol.2004.04.002","journal-title":"Exp Neurol"},{"key":"9123_CR177","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.neuron.2008.07.033","volume":"59","author":"SH Choi","year":"2008","unstructured":"Choi SH, Veeraraghavalu K, Lazarov O, Marler S et al (2008) Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron 59:568\u2013580. doi: 10.1016\/j.neuron.2008.07.033","journal-title":"Neuron"},{"key":"9123_CR178","doi-asserted-by":"publisher","first-page":"9148","DOI":"10.1073\/pnas.1302106110","volume":"110","author":"K Veeraraghavalu","year":"2013","unstructured":"Veeraraghavalu K, Sisodia SS (2013) Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proc Natl Acad Sci U S A 110:9148\u20139153. doi: 10.1073\/pnas.1302106110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9123_CR179","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3969\/j.issn. 1673-5374.2013.01.003","volume":"8","author":"Z Ma","year":"2013","unstructured":"Ma Z, Li Q, Zhang Z, Zheng Y (2013) A disintegrin and metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res 8:24\u201330. doi: 10.3969\/j.issn. 1673-5374.2013.01.003","journal-title":"Neural Regen Res"},{"key":"9123_CR180","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/sj.jcbfm.9600390","volume":"27","author":"M Katakowski","year":"2007","unstructured":"Katakowski M, Chen J, Zhang ZG, Santra M et al (2007) Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-\u03b1-converting enzyme protease activity. J Cereb Blood Flow Metab 27:669\u2013678. doi: 10.1038\/sj.jcbfm.9600390","journal-title":"J Cereb Blood Flow Metab"},{"key":"9123_CR181","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neulet.2013.01.021","volume":"537","author":"X Chen","year":"2013","unstructured":"Chen X, Chen L, Zhang R, Yi Y et al (2013) ADAM17 regulates self-renewal and differentiation of U87 glioblastoma stem cells. Neurosci Lett 537:44\u201349. doi: 10.1016\/j.neulet.2013.01.021","journal-title":"Neurosci Lett"},{"key":"9123_CR182","doi-asserted-by":"publisher","first-page":"12252","DOI":"10.1523\/JNEUROSCI. 1305-10.2010","volume":"30","author":"L Crews","year":"2010","unstructured":"Crews L, Adame A, Patrick C, Delaney A et al (2010) Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. J Neurosci 30:12252\u201312262. doi: 10.1523\/JNEUROSCI. 1305-10.2010","journal-title":"J Neurosci"},{"key":"9123_CR183","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1471-4159.2004.02949.x","volume":"93","author":"RJ Griffin","year":"2005","unstructured":"Griffin RJ, Moloney A, Kelliher M, Johnston JA et al (2005) Activation of Akt\/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem 93:105\u2013117. doi: 10.1111\/j.1471-4159.2004.02949.x","journal-title":"J Neurochem"},{"key":"9123_CR184","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.bbrc.2009.12.051","volume":"391","author":"N Aoyagi","year":"2010","unstructured":"Aoyagi N, Uemura K, Kuzuya A, Kihara T et al (2010) PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity. Biochem Biophys Res Commun 391:1240\u20131245. doi: 10.1016\/j.bbrc.2009.12.051","journal-title":"Biochem Biophys Res Commun"},{"key":"9123_CR185","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.neurobiolaging.2008.04.002","volume":"31","author":"AM Moloney","year":"2010","unstructured":"Moloney AM, Griffin RJ, Timmons S, O'Connor R et al (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1\/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 31:224\u2013243. doi: 10.1016\/j.neurobiolaging.2008.04.002","journal-title":"Neurobiol Aging"},{"key":"9123_CR186","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1172\/JCI59903","volume":"122","author":"K Talbot","year":"2012","unstructured":"Talbot K, Wang HY, Kazi H, Han LY et al (2012) Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122:1316\u20131338. doi: 10.1172\/JCI59903","journal-title":"J Clin Invest"},{"key":"9123_CR187","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nature01640","volume":"423","author":"CJ Phiel","year":"2003","unstructured":"Phiel CJ, Wilson CA, Lee VM, Klein PS (2003) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423:435\u2013439. doi: 10.1038\/nature01640","journal-title":"Nature"},{"key":"9123_CR188","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0002-9440(10)62962-8","volume":"167","author":"NL Chevallier","year":"2005","unstructured":"Chevallier NL, Soriano S, Kang DE, Masliah E et al (2005) Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol 167:151\u2013159. doi: 10.1016\/S0002-9440(10)62962-8","journal-title":"Am J Pathol"},{"key":"9123_CR189","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.yexcr.2004.02.028","volume":"297","author":"AR Alvarez","year":"2004","unstructured":"Alvarez AR, Godoy JA, Mullendorff K, Olivares GH et al (2004) Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res 297:186\u2013196. doi: 10.1016\/j.yexcr.2004.02.028","journal-title":"Exp Cell Res"},{"key":"9123_CR190","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fncel.2013.00097","volume":"7","author":"C Silva-Alvarez","year":"2013","unstructured":"Silva-Alvarez C, Arrazola MS, Godoy JA, Ordenes D et al (2013) Canonical Wnt signaling protects hippocampal neurons from Abeta oligomers: role of non-canonical Wnt-5a\/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci 7:97. doi: 10.3389\/fncel.2013.00097","journal-title":"Front Cell Neurosci"},{"key":"9123_CR191","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1750-1326-3-9","volume":"3","author":"NC Inestrosa","year":"2008","unstructured":"Inestrosa NC, Toledo EM (2008) The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease. Mol Neurodegener 3:9. doi: 10.1186\/1750-1326-3-9","journal-title":"Mol Neurodegener"},{"key":"9123_CR192","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1750-1326-5-3","volume":"5","author":"W Cerpa","year":"2010","unstructured":"Cerpa W, Farias GG, Godoy JA, Fuenzalida M et al (2010) Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener 5:3. doi: 10.1186\/1750-1326-5-3","journal-title":"Mol Neurodegener"},{"key":"9123_CR193","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1101\/gad.836900","volume":"14","author":"R Kopan","year":"2000","unstructured":"Kopan R, Goate A (2000) A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev 14:2799\u20132806. doi: 10.1101\/gad.836900","journal-title":"Genes Dev"},{"key":"9123_CR194","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.bbamcr.2007.02.001","volume":"1773","author":"SY Kim","year":"2007","unstructured":"Kim SY, Kim MY, Mo JS, Park HS (2007) Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction. Biochim Biophys Acta 1773:736\u2013746. doi: 10.1016\/j.bbamcr.2007.02.001","journal-title":"Biochim Biophys Acta"},{"key":"9123_CR195","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/ncb1690","volume":"10","author":"QH Ma","year":"2008","unstructured":"Ma QH, Futagawa T, Yang WL, Jiang XD et al (2008) A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol 10:283\u2013294. doi: 10.1038\/ncb1690","journal-title":"Nat Cell Biol"},{"key":"9123_CR196","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1002\/jnr.22387","volume":"88","author":"M Demars","year":"2010","unstructured":"Demars M, Hu YS, Gadadhar A, Lazarov O (2010) Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res 88:2103\u20132117. doi: 10.1002\/jnr.22387","journal-title":"J Neurosci Res"},{"key":"9123_CR197","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/neup.12020","volume":"33","author":"SU Kim","year":"2013","unstructured":"Kim SU, Lee HJ, Kim YB (2013) Neural stem cell-based treatment for neurodegenerative diseases. Neuropathology 33:491\u2013504. doi: 10.1111\/neup.12020","journal-title":"Neuropathology"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9123-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9123-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9123-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9123-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T21:29:23Z","timestamp":1651267763000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-015-9123-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,18]]},"references-count":197,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["9123"],"URL":"https:\/\/doi.org\/10.1007\/s12035-015-9123-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,18]]}}}