{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:16:52Z","timestamp":1793146612092,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s12035-015-9156-8","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T05:52:31Z","timestamp":1429509151000},"page":"2894-2899","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["MicroRNA-29a Is a Candidate Biomarker for Alzheimer\u2019s Disease in Cell-Free Cerebrospinal Fluid"],"prefix":"10.1007","volume":"53","author":[{"given":"Mareike","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke","family":"J\u00e4kel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona B.","family":"Bruinsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen A.","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bea","family":"Kuiperij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel M.","family":"Verbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"9156_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fnagi.2014.00047","volume":"6","author":"D Ferreira","year":"2014","unstructured":"Ferreira D, Perestelo-Perez L, Westman E, Wahlund LO, Sarria A, Serrano-Aguilar P (2014) Meta-review of CSF core biomarkers in Alzheimer's disease: the state-of-the-art after the new revised diagnostic criteria. Front Aging Neurosci 6:47. doi: 10.3389\/fnagi.2014.00047","journal-title":"Front Aging Neurosci"},{"issue":"17","key":"9156_CR2","doi-asserted-by":"publisher","first-page":"6415","DOI":"10.1073\/pnas.0710263105","volume":"105","author":"SS Hebert","year":"2008","unstructured":"Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A et al (2008) Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer's disease correlates with increased BACE1\/beta-secretase expression. Proc Natl Acad Sci U S A 105(17):6415\u20136420. doi: 10.1073\/pnas.0710263105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"46","key":"9156_CR3","doi-asserted-by":"publisher","first-page":"31315","DOI":"10.1074\/jbc.M805371200","volume":"283","author":"WJ Lukiw","year":"2008","unstructured":"Lukiw WJ, Zhao Y, Cui JG (2008) An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem 283(46):31315\u201331322. doi: 10.1074\/jbc.M805371200","journal-title":"J Biol Chem"},{"issue":"5","key":"9156_CR4","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1523\/JNEUROSCI. 5065-07.2008","volume":"28","author":"WX Wang","year":"2008","unstructured":"Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT (2008) The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28(5):1213\u20131223. doi: 10.1523\/JNEUROSCI. 5065-07.2008","journal-title":"J Neurosci"},{"issue":"6","key":"9156_CR5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1517\/14712590902932889","volume":"9","author":"MA Cortez","year":"2009","unstructured":"Cortez MA, Calin GA (2009) MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin Biol Ther 9(6):703\u2013711. doi: 10.1517\/14712590902932889","journal-title":"Expert Opin Biol Ther"},{"issue":"10","key":"9156_CR6","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.7150\/ijbs.6100","volume":"9","author":"LL Lv","year":"2013","unstructured":"Lv LL, Cao Y, Liu D, Xu M, Liu H, Tang RN, Ma KL, Liu BC (2013) Isolation and quantification of microRNAs from urinary exosomes\/microvesicles for biomarker discovery. Int J Biol Sci 9(10):1021\u20131031. doi: 10.7150\/ijbs.6100","journal-title":"Int J Biol Sci"},{"issue":"2","key":"9156_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12031-012-9731-7","volume":"47","author":"JA Gallego","year":"2012","unstructured":"Gallego JA, Gordon ML, Claycomb K, Bhatt M, Lencz T, Malhotra AK (2012) In vivo microRNA detection and quantitation in cerebrospinal fluid. J Mol Neurosci 47(2):243\u2013248. doi: 10.1007\/s12031-012-9731-7","journal-title":"J Mol Neurosci"},{"issue":"24","key":"9156_CR8","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1212\/01.wnl.0000437306.37850.22","volume":"81","author":"C Sala Frigerio","year":"2013","unstructured":"Sala Frigerio C, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R, Wallin A, Bjerke M et al (2013) Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology 81(24):2103\u20132106. doi: 10.1212\/01.wnl.0000437306.37850.22","journal-title":"Neurology"},{"issue":"2","key":"9156_CR9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-130932","volume":"39","author":"T Kiko","year":"2014","unstructured":"Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T (2014) MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. J Alzheimers Dis 39(2):253\u2013259","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"9156_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","volume":"35","author":"M M\u00fcller","year":"2014","unstructured":"M\u00fcller M, Kuiperij HB, Claassen JA, Kusters B, Verbeek MM (2014) MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid. Neurobiol Aging 35(1):152\u2013158. doi: 10.1016\/j.neurobiolaging.2013.07.005","journal-title":"Neurobiol Aging"},{"issue":"7","key":"9156_CR11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34(7):939\u2013944","journal-title":"Neurology"},{"issue":"3","key":"9156_CR12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ et al (2011) The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7(3):263\u2013269. doi: 10.1016\/j.jalz.2011.03.005","journal-title":"Alzheimers Dement"},{"key":"9156_CR13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fgene.2013.00150","volume":"4","author":"L Cheng","year":"2013","unstructured":"Cheng L, Quek CY, Sun X, Bellingham SA, Hill AF (2013) The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies. Front Genet 4:150. doi: 10.3389\/fgene.2013.00150","journal-title":"Front Genet"},{"issue":"2","key":"9156_CR14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.nbd.2012.01.003","volume":"46","author":"C Delay","year":"2012","unstructured":"Delay C, Mandemakers W, Hebert SS (2012) MicroRNAs in Alzheimer's disease. Neurobiol Dis 46(2):285\u2013290. doi: 10.1016\/j.nbd.2012.01.003","journal-title":"Neurobiol Dis"},{"issue":"1","key":"9156_CR15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","volume":"14","author":"JP Cogswell","year":"2008","unstructured":"Cogswell JP, Ward J, Taylor IA, Waters M, Shi YL, Cannon B, Kelnar K, Kemppainen J et al (2008) Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14(1):27\u201341","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"9156_CR16","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1365-2990.2010.01076.x","volume":"36","author":"M Shioya","year":"2010","unstructured":"Shioya M, Obayashi S, Tabunoki H, Arima K, Saito Y, Ishida T, Satoh J (2010) Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. Neuropathol Appl Neurobiol 36(4):320\u2013330. doi: 10.1111\/j.1365-2990.2010.01076.x","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"9156_CR17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","volume":"459","author":"P Sethi","year":"2009","unstructured":"Sethi P, Lukiw WJ (2009) Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci Lett 459(2):100\u2013104. doi: 10.1016\/j.neulet.2009.04.052","journal-title":"Neurosci Lett"},{"issue":"2","key":"9156_CR18","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","volume":"235","author":"H Geekiyanage","year":"2012","unstructured":"Geekiyanage H, Jicha GA, Nelson PT, Chan C (2012) Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease. Exp Neurol 235(2):491\u2013496. doi: 10.1016\/j.expneurol.2011.11.026","journal-title":"Exp Neurol"},{"issue":"19","key":"9156_CR19","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.18632\/oncotarget.2419","volume":"5","author":"P Leidinger","year":"2014","unstructured":"Leidinger P, Backes C, Dahmke IN, Galata V, Huwer H, Stehle I, Bals R, Keller A et al (2014) What makes a blood cell based miRNA expression pattern disease specific?\u2014a miRNome analysis of blood cell subsets in lung cancer patients and healthy controls. Oncotarget 5(19):9484\u20139497","journal-title":"Oncotarget"},{"key":"9156_CR20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-1-60761-811-9_13","volume":"667","author":"C Sangokoya","year":"2010","unstructured":"Sangokoya C, LaMonte G, Chi JT (2010) Isolation and characterization of microRNAs of human mature erythrocytes. Methods Mol Biol 667:193\u2013203. doi: 10.1007\/978-1-60761-811-9_13","journal-title":"Methods Mol Biol"},{"key":"9156_CR21","first-page":"263","volume":"1","author":"HM Schipper","year":"2007","unstructured":"Schipper HM, Maes OC, Chertkow HM, Wang E (2007) MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regul Syst Biol 1:263\u2013274","journal-title":"Gene Regul Syst Biol"},{"key":"9156_CR22","doi-asserted-by":"crossref","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3 (7):RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"9156_CR23","doi-asserted-by":"publisher","unstructured":"Li J, Liu Y, Kim T, Min R, Zhang Z (2010) Gene expression variability within and between human populations and implications toward disease susceptibility. PLoS Comput Biol 6(8). doi: 10.1371\/journal.pcbi.1000910","DOI":"10.1371\/journal.pcbi.1000910"},{"key":"9156_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3389\/fncel.2013.00133","volume":"7","author":"WJ Lukiw","year":"2013","unstructured":"Lukiw WJ (2013) Variability in micro RNA (miRNA) abundance, speciation and complexity amongst different human populations and potential relevance to Alzheimer's disease (AD). Front Cell Neurosci 7:133. doi: 10.3389\/fncel.2013.00133","journal-title":"Front Cell Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9156-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9156-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9156-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9156-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T09:49:59Z","timestamp":1717840199000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-015-9156-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,21]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["9156"],"URL":"https:\/\/doi.org\/10.1007\/s12035-015-9156-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,21]]}}}