{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:37:59Z","timestamp":1790786279281,"version":"4.1.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T00:00:00Z","timestamp":1434758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s12035-015-9242-y","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T04:29:49Z","timestamp":1434688189000},"page":"3462-3476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-\u03baB Pathway and NLRP3 Inflammasome"],"prefix":"10.1007","volume":"53","author":[{"given":"Anwen","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,20]]},"reference":[{"issue":"11","key":"9242_CR1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/cns.12001","volume":"18","author":"LH Bian","year":"2012","unstructured":"Bian LH, Liu YF, Nichols LT, Wang CX, Wang YL, Liu GF, Wang WJ, Zhao XQ (2012) Epidemiology of subarachnoid hemorrhage, patterns of management, and outcomes in China: a hospital-based multicenter prospective study. CNS Neurosci Ther 18(11):895\u2013902. doi: 10.1111\/cns.12001","journal-title":"CNS Neurosci Ther"},{"issue":"9558","key":"9242_CR2","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S0140-6736(07)60153-6","volume":"369","author":"J Gijn van","year":"2007","unstructured":"van Gijn J, Kerr RS, Rinkel GJ (2007) Subarachnoid haemorrhage. Lancet 369(9558):306\u2013318. doi: 10.1016\/S0140-6736(07)60153-6","journal-title":"Lancet"},{"key":"9242_CR3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1159\/000333625","volume":"30","author":"M Venti","year":"2012","unstructured":"Venti M (2012) Subarachnoid and intraventricular hemorrhage. Front Neurol Neurosci 30:149\u2013153. doi: 10.1159\/000333625","journal-title":"Front Neurol Neurosci"},{"issue":"9","key":"9242_CR4","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1038\/jcbfm.2012.57","volume":"32","author":"T Zoerle","year":"2012","unstructured":"Zoerle T, Ilodigwe DC, Wan H, Lakovic K, Sabri M, Ai J, Macdonald RL (2012) Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: systematic review and meta-analysis. J Cereb Blood Flow Metab 32(9):1645\u20131658. doi: 10.1038\/jcbfm.2012.57","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"9242_CR5","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1161\/STROKEAHA.110.597005","volume":"42","author":"RW Crowley","year":"2011","unstructured":"Crowley RW, Medel R, Dumont AS, Ilodigwe D, Kassell NF, Mayer SA, Ruefenacht D, Schmiedek P et al (2011) Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage. Stroke 42(4):919\u2013923. doi: 10.1161\/STROKEAHA.110.597005","journal-title":"Stroke"},{"issue":"5","key":"9242_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/ncpneuro0490","volume":"3","author":"RL Macdonald","year":"2007","unstructured":"Macdonald RL, Pluta RM, Zhang JH (2007) Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution. Nat Clin Pract Neurol 3(5):256\u2013263. doi: 10.1038\/ncpneuro0490","journal-title":"Nat Clin Pract Neurol"},{"issue":"11","key":"9242_CR7","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1161\/01.STR.0000144654.79393.cf","volume":"35","author":"ME Baldwin","year":"2004","unstructured":"Baldwin ME, Macdonald RL, Huo D, Novakovic RL, Goldenberg FD, Frank JI, Rosengart AJ (2004) Early vasospasm on admission angiography in patients with aneurysmal subarachnoid hemorrhage is a predictor for in-hospital complications and poor outcome. Stroke 35(11):2506\u20132511. doi: 10.1161\/01.STR.0000144654.79393.cf","journal-title":"Stroke"},{"issue":"5\u20136","key":"9242_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.drudis.2007.11.010","volume":"13","author":"RW Crowley","year":"2008","unstructured":"Crowley RW, Medel R, Kassell NF, Dumont AS (2008) New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage. Drug Discov Today 13(5\u20136):254\u2013260. doi: 10.1016\/j.drudis.2007.11.010","journal-title":"Drug Discov Today"},{"issue":"10","key":"9242_CR9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(03)00531-3","volume":"2","author":"J Sen","year":"2003","unstructured":"Sen J, Belli A, Albon H, Morgan L, Petzold A, Kitchen N (2003) Triple-H therapy in the management of aneurysmal subarachnoid haemorrhage. Lancet Neurol 2(10):614\u2013621","journal-title":"Lancet Neurol"},{"issue":"7","key":"9242_CR10","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S1474-4422(11)70108-9","volume":"10","author":"RL Macdonald","year":"2011","unstructured":"Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I et al (2011) Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol 10(7):618\u2013625. doi: 10.1016\/S1474-4422(11)70108-9","journal-title":"Lancet Neurol"},{"issue":"6","key":"9242_CR11","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1161\/STROKEAHA.111.648980","volume":"43","author":"RL Macdonald","year":"2012","unstructured":"Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I et al (2012) Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke 43(6):1463\u20131469. doi: 10.1161\/STROKEAHA.111.648980","journal-title":"Stroke"},{"issue":"1","key":"9242_CR12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3171\/2013.3.JNS121436","volume":"119","author":"J Shen","year":"2013","unstructured":"Shen J, Pan JW, Fan ZX, Xiong XX, Zhan RY (2013) Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials. J Neurosurg 119(1):180\u2013189. doi: 10.3171\/2013.3.JNS121436","journal-title":"J Neurosurg"},{"issue":"4","key":"9242_CR13","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12975-013-0257-2","volume":"4","author":"M Fujii","year":"2013","unstructured":"Fujii M, Yan J, Rolland WB, Soejima Y, Caner B, Zhang JH (2013) Early brain injury, an evolving frontier in subarachnoid hemorrhage research. Transl Stroke Res 4(4):432\u2013446. doi: 10.1007\/s12975-013-0257-2","journal-title":"Transl Stroke Res"},{"issue":"Suppl 2","key":"9242_CR14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1471-4159.2012.07939.x","volume":"123","author":"B Caner","year":"2012","unstructured":"Caner B, Hou J, Altay O, Fujii M, Zhang JH (2012) Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage. J Neurochem 123(Suppl 2):12\u201321. doi: 10.1111\/j.1471-4159.2012.07939.x","journal-title":"J Neurochem"},{"issue":"1","key":"9242_CR15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pneurobio.2012.02.003","volume":"97","author":"FA Sehba","year":"2012","unstructured":"Sehba FA, Hou J, Pluta RM, Zhang JH (2012) The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol 97(1):14\u201337. doi: 10.1016\/j.pneurobio.2012.02.003","journal-title":"Prog Neurobiol"},{"issue":"1","key":"9242_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12035-010-8155-z","volume":"43","author":"FA Sehba","year":"2011","unstructured":"Sehba FA, Pluta RM, Zhang JH (2011) Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol 43(1):27\u201340. doi: 10.1007\/s12035-010-8155-z","journal-title":"Mol Neurobiol"},{"issue":"4","key":"9242_CR17","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/jcbfm.2009.278","volume":"30","author":"AF Ducruet","year":"2010","unstructured":"Ducruet AF, Gigante PR, Hickman ZL, Zacharia BE, Arias EJ, Grobelny BT, Gorski JW, Mayer SA et al (2010) Genetic determinants of cerebral vasospasm, delayed cerebral ischemia, and outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab 30(4):676\u2013688. doi: 10.1038\/jcbfm.2009.278","journal-title":"J Cereb Blood Flow Metab"},{"key":"9242_CR18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-211-75718-5_7","volume":"104","author":"RE Ayer","year":"2008","unstructured":"Ayer RE, Zhang JH (2008) Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir Suppl 104:33\u201341","journal-title":"Acta Neurochir Suppl"},{"issue":"1","key":"9242_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3171\/2014.2.JNS13730","volume":"121","author":"XS Zhang","year":"2014","unstructured":"Zhang XS, Zhang X, Zhou ML, Zhou XM, Li N, Li W, Cong ZX, Sun Q et al (2014) Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage. J Neurosurg 121(1):42\u201354. doi: 10.3171\/2014.2.JNS13730","journal-title":"J Neurosurg"},{"issue":"4","key":"9242_CR20","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3171\/2013.4.JNS121919","volume":"119","author":"CP Kuo","year":"2013","unstructured":"Kuo CP, Wen LL, Chen CM, Huh B, Cherng CH, Wong CS, Liaw WJ, Yeh CC et al (2013) Attenuation of neurological injury with early baicalein treatment following subarachnoid hemorrhage in rats. J Neurosurg 119(4):1028\u20131037. doi: 10.3171\/2013.4.JNS121919","journal-title":"J Neurosurg"},{"issue":"2","key":"9242_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1600-079X.2012.00978.x","volume":"53","author":"Z Wang","year":"2012","unstructured":"Wang Z, Ma C, Meng CJ, Zhu GQ, Sun XB, Huo L, Zhang J, Liu HX et al (2012) Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res 53(2):129\u2013137. doi: 10.1111\/j.1600-079X.2012.00978.x","journal-title":"J Pineal Res"},{"key":"9242_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/1742-2094-10-157","volume":"10","author":"X Sun","year":"2013","unstructured":"Sun X, Ji C, Hu T, Wang Z, Chen G (2013) Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling. J Neuroinflammation 10:157. doi: 10.1186\/1742-2094-10-157","journal-title":"J Neuroinflammation"},{"key":"9242_CR23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.nbd.2013.06.011","volume":"58","author":"S Chen","year":"2013","unstructured":"Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J et al (2013) P2X7R\/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis 58:296\u2013307. doi: 10.1016\/j.nbd.2013.06.011","journal-title":"Neurobiol Dis"},{"issue":"9","key":"9242_CR24","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/cns.12122","volume":"19","author":"N Zhou","year":"2013","unstructured":"Zhou N, Xu T, Bai Y, Prativa S, Xu JZ, Li K, Han HB, Yan JH (2013) Protective effects of urinary trypsin inhibitor on vascular permeability following subarachnoid hemorrhage in a rat model. CNS Neurosci Ther 19(9):659\u2013666. doi: 10.1111\/cns.12122","journal-title":"CNS Neurosci Ther"},{"key":"9242_CR25","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1479-5876-10-80","volume":"10","author":"R Echigo","year":"2012","unstructured":"Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y et al (2012) Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med 10:80. doi: 10.1186\/1479-5876-10-80","journal-title":"J Transl Med"},{"key":"9242_CR26","doi-asserted-by":"publisher","first-page":"848309","DOI":"10.1155\/2011\/848309","volume":"2011","author":"Z Wang","year":"2011","unstructured":"Wang Z, Zuo G, Shi XY, Zhang J, Fang Q, Chen G (2011) Progesterone administration modulates cortical TLR4\/NF-kappaB signaling pathway after subarachnoid hemorrhage in male rats. Mediat Inflamm 2011:848309. doi: 10.1155\/2011\/848309","journal-title":"Mediat Inflamm"},{"issue":"2","key":"9242_CR27","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1097\/CCM.0b013e3181c027ae","volume":"38","author":"H Suzuki","year":"2010","unstructured":"Suzuki H, Ayer R, Sugawara T, Chen W, Sozen T, Hasegawa Y, Kanamaru K, Zhang JH (2010) Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats. Crit Care Med 38(2):612\u2013618. doi: 10.1097\/CCM.0b013e3181c027ae","journal-title":"Crit Care Med"},{"issue":"2","key":"9242_CR28","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/ana.24070","volume":"75","author":"Q Ma","year":"2014","unstructured":"Ma Q, Chen S, Hu Q, Feng H, Zhang JH, Tang J (2014) NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol 75(2):209\u2013219. doi: 10.1002\/ana.24070","journal-title":"Ann Neurol"},{"issue":"4","key":"9242_CR29","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","volume":"34","author":"F Yang","year":"2014","unstructured":"Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F et al (2014) NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab 34(4):660\u2013667. doi: 10.1038\/jcbfm.2013.242","journal-title":"J Cereb Blood Flow Metab"},{"issue":"10","key":"9242_CR30","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1007\/s11064-013-1115-z","volume":"38","author":"HD Liu","year":"2013","unstructured":"Liu HD, Li W, Chen ZR, Hu YC, Zhang DD, Shen W, Zhou ML, Zhu L et al (2013) Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model. Neurochem Res 38(10):2072\u20132083. doi: 10.1007\/s11064-013-1115-z","journal-title":"Neurochem Res"},{"issue":"7","key":"9242_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103432","volume":"9","author":"L Tarassishin","year":"2014","unstructured":"Tarassishin L, Casper D, Lee SC (2014) Aberrant expression of interleukin-1beta and inflammasome activation in human malignant gliomas. PLoS One 9(7), e103432. doi: 10.1371\/journal.pone.0103432","journal-title":"PLoS One"},{"key":"9242_CR32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","volume":"36","author":"E Alcocer-Gomez","year":"2014","unstructured":"Alcocer-Gomez E, de Miguel M, Casas-Barquero N, Nunez-Vasco J, Sanchez-Alcazar JA, Fernandez-Rodriguez A, Cordero MD (2014) NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav Immun 36:111\u2013117. doi: 10.1016\/j.bbi.2013.10.017","journal-title":"Brain Behav Immun"},{"issue":"4","key":"9242_CR33","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1042\/AN20130021","volume":"5","author":"GE Bigford","year":"2013","unstructured":"Bigford GE, Bracchi-Ricard VC, Keane RW, Nash MS, Bethea JR (2013) Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse. ASN Neuro 5(4):243\u2013255. doi: 10.1042\/AN20130021","journal-title":"ASN Neuro"},{"issue":"3","key":"9242_CR34","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s12035-013-8475-x","volume":"48","author":"MS Tan","year":"2013","unstructured":"Tan MS, Yu JT, Jiang T, Zhu XC, Tan L (2013) The NLRP3 inflammasome in Alzheimer\u2019s disease. Mol Neurobiol 48(3):875\u2013882. doi: 10.1007\/s12035-013-8475-x","journal-title":"Mol Neurobiol"},{"issue":"10","key":"9242_CR35","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.4049\/jimmunol.1100790","volume":"187","author":"T Hoegen","year":"2011","unstructured":"Hoegen T, Tremel N, Klein M, Angele B, Wagner H, Kirschning C, Pfister HW, Fontana A et al (2011) The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. J Immunol 187(10):5440\u20135451. doi: 10.4049\/jimmunol.1100790","journal-title":"J Immunol"},{"key":"9242_CR36","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5868","author":"X Zhang","year":"2015","unstructured":"Zhang X, Zhang JH, Chen XY, Hu QH, Wang MX, Jin R, Zhang QY, Wang W et al (2015) ROS-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal. doi: 10.1089\/ars.2014.5868","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"9242_CR37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1254\/jjp.88.227","volume":"88","author":"R Sercombe","year":"2002","unstructured":"Sercombe R, Dinh YR, Gomis P (2002) Cerebrovascular inflammation following subarachnoid hemorrhage. Jpn J Pharmacol 88(3):227\u2013249","journal-title":"Jpn J Pharmacol"},{"key":"9242_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1471-2202-13-47","volume":"13","author":"Z Zhuang","year":"2012","unstructured":"Zhuang Z, Zhou ML, You WC, Zhu L, Ma CY, Sun XJ, Shi JX (2012) Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci 13:47. doi: 10.1186\/1471-2202-13-47","journal-title":"BMC Neurosci"},{"issue":"12","key":"9242_CR39","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1002\/jnr.23281","volume":"91","author":"Z Zhuang","year":"2013","unstructured":"Zhuang Z, Sun XJ, Zhang X, Liu HD, You WC, Ma CY, Zhu L, Zhou ML et al (2013) Nuclear factor-kappaB\/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res 91(12):1599\u20131608. doi: 10.1002\/jnr.23281","journal-title":"J Neurosci Res"},{"issue":"4","key":"9242_CR40","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1097\/CCM.0b013e31823da96d","volume":"40","author":"Y Zhan","year":"2012","unstructured":"Zhan Y, Chen C, Suzuki H, Hu Q, Zhi X, Zhang JH (2012) Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med 40(4):1291\u20131296. doi: 10.1097\/CCM.0b013e31823da96d","journal-title":"Crit Care Med"},{"issue":"2","key":"9242_CR41","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","volume":"167","author":"T Sugawara","year":"2008","unstructured":"Sugawara T, Ayer R, Jadhav V, Zhang JH (2008) A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods 167(2):327\u2013334. doi: 10.1016\/j.jneumeth.2007.08.004","journal-title":"J Neurosci Methods"},{"issue":"4","key":"9242_CR42","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1097\/CCM.0b013e318206bf44","volume":"39","author":"Q Sun","year":"2011","unstructured":"Sun Q, Cai J, Zhou J, Tao H, Zhang JH, Zhang W, Sun XJ (2011) Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Crit Care Med 39(4):765\u2013769. doi: 10.1097\/CCM.0b013e318206bf44","journal-title":"Crit Care Med"},{"issue":"6","key":"9242_CR43","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nm1577","volume":"13","author":"I Ohsawa","year":"2007","unstructured":"Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y et al (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13(6):688\u2013694. doi: 10.1038\/nm1577","journal-title":"Nat Med"},{"issue":"4","key":"9242_CR44","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","volume":"26","author":"JH Garcia","year":"1995","unstructured":"Garcia JH, Wagner S, Liu KF, Hu XJ (1995) Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke 26(4):627\u2013634, discussion 635","journal-title":"Stroke"},{"issue":"10","key":"9242_CR45","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.7150\/ijms.9282","volume":"11","author":"A Shao","year":"2014","unstructured":"Shao A, Guo S, Tu S, Ammar AB, Tang J, Hong Y, Wu H, Zhang J (2014) Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats. Int J Med Sci 11(10):1073\u20131081. doi: 10.7150\/ijms.9282","journal-title":"Int J Med Sci"},{"key":"9242_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8986-0","author":"A Shao","year":"2014","unstructured":"Shao A, Wang Z, Wu H, Dong X, Li Y, Tu S, Tang J, Zhao M et al (2014) Enhancement of autophagy by histone deacetylase inhibitor trichostatin a ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats. Mol Neurobiol. doi: 10.1007\/s12035-014-8986-0","journal-title":"Mol Neurobiol"},{"issue":"2","key":"9242_CR47","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1227\/01.NEU.0000345649.78556.26","volume":"65","author":"JY Lee","year":"2009","unstructured":"Lee JY, Sagher O, Keep R, Hua Y, Xi G (2009) Comparison of experimental rat models of early brain injury after subarachnoid hemorrhage. Neurosurgery 65(2):331\u2013343. doi: 10.1227\/01.NEU.0000345649.78556.26 , discussion 343","journal-title":"Neurosurgery"},{"issue":"19","key":"9242_CR48","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1016\/S0021-9258(17)39909-X","volume":"252","author":"EW Kellogg 3rd","year":"1977","unstructured":"Kellogg EW 3rd, Fridovich I (1977) Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide. J Biol Chem 252(19):6721\u20136728","journal-title":"J Biol Chem"},{"issue":"21","key":"9242_CR49","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1016\/S0021-9258(19)44679-6","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I (1972) The generation of superoxide radical during the autoxidation of hemoglobin. J Biol Chem 247(21):6960\u20136962","journal-title":"J Biol Chem"},{"issue":"5","key":"9242_CR50","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.neuint.2012.10.013","volume":"62","author":"M Skowronska","year":"2013","unstructured":"Skowronska M, Albrecht J (2013) Oxidative and nitrosative stress in ammonia neurotoxicity. Neurochem Int 62(5):731\u2013737. doi: 10.1016\/j.neuint.2012.10.013","journal-title":"Neurochem Int"},{"issue":"10","key":"9242_CR51","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1089\/ARS.2009.2578","volume":"11","author":"S Sorce","year":"2009","unstructured":"Sorce S, Krause KH (2009) NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal 11(10):2481\u20132504. doi: 10.1089\/ARS.2009.2578","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"9242_CR52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biopha.2003.11.004","volume":"58","author":"J Emerit","year":"2004","unstructured":"Emerit J, Edeas M, Bricaire F (2004) Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 58(1):39\u201346","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"9242_CR53","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.intimp.2014.04.011","volume":"21","author":"J Zhang","year":"2014","unstructured":"Zhang J, Wu Q, Song S, Wan Y, Zhang R, Tai M, Liu C (2014) Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol 21(1):94\u2013101. doi: 10.1016\/j.intimp.2014.04.011","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"9242_CR54","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1002\/mds.25375","volume":"28","author":"A Yoritaka","year":"2013","unstructured":"Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N (2013) Pilot study of H(2) therapy in Parkinson\u2019s disease: a randomized double-blind placebo-controlled trial. Mov Disord 28(6):836\u2013839. doi: 10.1002\/mds.25375","journal-title":"Mov Disord"},{"issue":"7","key":"9242_CR55","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1464-5491.1990.tb01457.x","volume":"7","author":"CF Finch","year":"1990","unstructured":"Finch CF, Zimmet PZ, Alberti KG (1990) Determining diabetes prevalence: a rational basis for the use of fasting plasma glucose concentrations? Diabet Med 7(7):603\u2013610","journal-title":"Diabet Med"},{"issue":"5","key":"9242_CR56","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1097\/CCM.0b013e31827711c9","volume":"41","author":"A Manaenko","year":"2013","unstructured":"Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J (2013) Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Crit Care Med 41(5):1266\u20131275. doi: 10.1097\/CCM.0b013e31827711c9","journal-title":"Crit Care Med"},{"issue":"2","key":"9242_CR57","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.neulet.2008.05.077","volume":"441","author":"J Cai","year":"2008","unstructured":"Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X et al (2008) Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett 441(2):167\u2013172. doi: 10.1016\/j.neulet.2008.05.077","journal-title":"Neurosci Lett"},{"key":"9242_CR58","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.brainres.2010.07.038","volume":"1354","author":"X Ji","year":"2010","unstructured":"Ji X, Liu W, Xie K, Liu W, Qu Y, Chao X, Chen T, Zhou J et al (2010) Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Res 1354:196\u2013205. doi: 10.1016\/j.brainres.2010.07.038","journal-title":"Brain Res"},{"issue":"8","key":"9242_CR59","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/cns.12258","volume":"20","author":"FT Liu","year":"2014","unstructured":"Liu FT, Xu SM, Xiang ZH, Li XN, Li J, Yuan HB, Sun XJ (2014) Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats. CNS Neurosci Ther 20(8):778\u2013786. doi: 10.1111\/cns.12258","journal-title":"CNS Neurosci Ther"},{"key":"9242_CR60","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000316","author":"H Liu","year":"2015","unstructured":"Liu H, Liang X, Wang D, Zhang H, Liu L, Chen H, Li Y, Duan Q et al (2015) Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock. doi: 10.1097\/SHK.0000000000000316","journal-title":"Shock"},{"issue":"2","key":"9242_CR61","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.burns.2014.07.012","volume":"41","author":"X Wang","year":"2015","unstructured":"Wang X, Yu P, YongYang LX, Jiang J, Liu D, Xue G (2015) Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. Burns 41(2):379\u2013385. doi: 10.1016\/j.burns.2014.07.012","journal-title":"Burns"},{"key":"9242_CR62","doi-asserted-by":"publisher","first-page":"930894","DOI":"10.1155\/2014\/930894","volume":"2014","author":"JD Ren","year":"2014","unstructured":"Ren JD, Ma J, Hou J, Xiao WJ, Jin WH, Wu J, Fan KH (2014) Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediat Inflamm 2014:930894. doi: 10.1155\/2014\/930894","journal-title":"Mediat Inflamm"},{"key":"9242_CR63","doi-asserted-by":"publisher","first-page":"786242","DOI":"10.1155\/2012\/786242","volume":"2012","author":"WC You","year":"2012","unstructured":"You WC, Li W, Zhuang Z, Tang Y, Lu HC, Ji XJ, Shen W, Shi JX et al (2012) Biphasic activation of nuclear factor-kappa B in experimental models of subarachnoid hemorrhage in vivo and in vitro. Mediat Inflamm 2012:786242. doi: 10.1155\/2012\/786242","journal-title":"Mediat Inflamm"},{"issue":"3","key":"9242_CR64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060290","volume":"8","author":"WC You","year":"2013","unstructured":"You WC, Wang CX, Pan YX, Zhang X, Zhou XM, Zhang XS, Shi JX, Zhou ML (2013) Activation of nuclear factor-kappaB in the brain after experimental subarachnoid hemorrhage and its potential role in delayed brain injury. PLoS One 8(3), e60290. doi: 10.1371\/journal.pone.0060290","journal-title":"PLoS One"},{"issue":"9","key":"9242_CR65","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/sj.jcbfm.9600456","volume":"27","author":"ML Zhou","year":"2007","unstructured":"Zhou ML, Shi JX, Hang CH, Cheng HL, Qi XP, Mao L, Chen KF, Yin HX (2007) Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits. J Cereb Blood Flow Metab 27(9):1583\u20131592. doi: 10.1038\/sj.jcbfm.9600456","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"9242_CR66","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s12035-013-8509-4","volume":"49","author":"W Li","year":"2014","unstructured":"Li W, Ling HP, You WC, Liu HD, Sun Q, Zhou ML, Shen W, Zhao JB et al (2014) Elevated cerebral cortical CD24 levels in patients and mice with traumatic brain injury: a potential negative role in nuclear factor kappaB\/inflammatory factor pathway. Mol Neurobiol 49(1):187\u2013198. doi: 10.1007\/s12035-013-8509-4","journal-title":"Mol Neurobiol"},{"issue":"3","key":"9242_CR67","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s12035-014-8697-6","volume":"49","author":"H Dong","year":"2014","unstructured":"Dong H, Zhang W, Zeng X, Hu G, Zhang H, He S, Zhang S (2014) Histamine induces upregulated expression of histamine receptors and increases release of inflammatory mediators from microglia. Mol Neurobiol 49(3):1487\u20131500. doi: 10.1007\/s12035-014-8697-6","journal-title":"Mol Neurobiol"},{"issue":"10","key":"9242_CR68","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.1096\/fj.14-253625","volume":"28","author":"S Zhang","year":"2014","unstructured":"Zhang S, Zis O, Ly PT, Wu Y, Zhang S, Zhang M, Cai F, Bucala R et al (2014) Down-regulation of MIF by NFkappaB under hypoxia accelerated neuronal loss during stroke. FASEB J 28(10):4394\u20134407. doi: 10.1096\/fj.14-253625","journal-title":"FASEB J"},{"issue":"2","key":"9242_CR69","first-page":"205","volume":"19","author":"RO Dantas","year":"1986","unstructured":"Dantas RO, Godoy RA, Oliveira RB, Villanova MG, Meneghelli UG, Troncon LE (1986) Effect of nifedipine on the lower esophageal sphincter pressure in chagasic patients. Braz J Med Biol Res 19(2):205\u2013209","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"9242_CR70","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/cns.12194","volume":"20","author":"AW Shao","year":"2014","unstructured":"Shao AW, Wu HJ, Chen S, Ammar AB, Zhang JM, Hong Y (2014) Resveratrol attenuates early brain injury after subarachnoid hemorrhage through inhibition of NF-kappaB-dependent inflammatory\/MMP-9 pathway. CNS Neurosci Ther 20(2):182\u2013185. doi: 10.1111\/cns.12194","journal-title":"CNS Neurosci Ther"},{"issue":"4","key":"9242_CR71","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/jnnp.70.4.534","volume":"70","author":"K Fassbender","year":"2001","unstructured":"Fassbender K, Hodapp B, Rossol S, Bertsch T, Schmeck J, Schutt S, Fritzinger M, Horn P et al (2001) Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J Neurol Neurosurg Psychiatry 70(4):534\u2013537","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"9242_CR72","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/156720212801619045","volume":"9","author":"M Larysz-Brysz","year":"2012","unstructured":"Larysz-Brysz M, Lewin-Kowalik J, Czuba Z, Kotulska K, Olakowska E, Marcol W, Liskiewicz A, Jedrzejowska-Szypulka H (2012) Interleukin-1beta increases release of endothelin-1 and tumor necrosis factor as well as reactive oxygen species by peripheral leukocytes during experimental subarachnoid hemorrhage. Curr Neurovasc Res 9(3):159\u2013166","journal-title":"Curr Neurovasc Res"},{"issue":"2","key":"9242_CR73","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.nec.2009.10.008","volume":"21","author":"G Pradilla","year":"2010","unstructured":"Pradilla G, Chaichana KL, Hoang S, Huang J, Tamargo RJ (2010) Inflammation and cerebral vasospasm after subarachnoid hemorrhage. Neurosurg Clin N Am 21(2):365\u2013379. doi: 10.1016\/j.nec.2009.10.008","journal-title":"Neurosurg Clin N Am"},{"issue":"6","key":"9242_CR74","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.12.004","volume":"23","author":"K Uekawa","year":"2014","unstructured":"Uekawa K, Hasegawa Y, Ma M, Nakagawa T, Katayama T, Sueta D, Toyama K, Kataoka K et al (2014) Rosuvastatin ameliorates early brain injury after subarachnoid hemorrhage via suppression of superoxide formation and nuclear factor-kappa B activation in rats. J Stroke Cerebrovasc Dis 23(6):1429\u20131439. doi: 10.1016\/j.jstrokecerebrovasdis.2013.12.004","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"4","key":"9242_CR75","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/jpi.12087","volume":"55","author":"Z Wang","year":"2013","unstructured":"Wang Z, Wu L, You W, Ji C, Chen G (2013) Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway. J Pineal Res 55(4):399\u2013408. doi: 10.1111\/jpi.12087","journal-title":"J Pineal Res"},{"issue":"7","key":"9242_CR76","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/01.STR.32.7.1652","volume":"32","author":"A Saito","year":"2001","unstructured":"Saito A, Kamii H, Kato I, Takasawa S, Kondo T, Chan PH, Okamoto H, Yoshimoto T (2001) Transgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage. Stroke 32(7):1652\u20131657","journal-title":"Stroke"},{"issue":"3","key":"9242_CR77","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","volume":"10","author":"J Tschopp","year":"2010","unstructured":"Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10(3):210\u2013215. doi: 10.1038\/nri2725","journal-title":"Nat Rev Immunol"},{"issue":"7329","key":"9242_CR78","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469(7329):221\u2013225. doi: 10.1038\/nature09663","journal-title":"Nature"},{"key":"9242_CR79","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ejphar.2014.09.046","volume":"745","author":"J Wu","year":"2014","unstructured":"Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, Liu K (2014) Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol 745:59\u201368. doi: 10.1016\/j.ejphar.2014.09.046","journal-title":"Eur J Pharmacol"},{"key":"9242_CR80","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijbiomac.2014.05.034","volume":"69","author":"J Xiao","year":"2014","unstructured":"Xiao J, Zhu Y, Liu Y, Tipoe GL, Xing F, So KF (2014) Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. Int J Biol Macromol 69:73\u201378. doi: 10.1016\/j.ijbiomac.2014.05.034","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"9242_CR81","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s00125-013-3115-6","volume":"57","author":"SM Yang","year":"2014","unstructured":"Yang SM, Ka SM, Wu HL, Yeh YC, Kuo CH, Hua KF, Shi GY, Hung YJ et al (2014) Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kappaB\/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis. Diabetologia 57(2):424\u2013434. doi: 10.1007\/s00125-013-3115-6","journal-title":"Diabetologia"},{"issue":"39","key":"9242_CR82","doi-asserted-by":"publisher","first-page":"27159","DOI":"10.1074\/jbc.M114.567537","volume":"289","author":"JM Abais","year":"2014","unstructured":"Abais JM, Xia M, Li G, Chen Y, Conley SM, Gehr TW, Boini KM, Li PL (2014) Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia. J Biol Chem 289(39):27159\u201327168. doi: 10.1074\/jbc.M114.567537","journal-title":"J Biol Chem"},{"issue":"4","key":"9242_CR83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096212","volume":"9","author":"Y Hong","year":"2014","unstructured":"Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, Wu Q, Sun X et al (2014) Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt\/GSK3beta signaling pathway. PLoS One 9(4), e96212. doi: 10.1371\/journal.pone.0096212","journal-title":"PLoS One"},{"issue":"26","key":"9242_CR84","doi-asserted-by":"publisher","first-page":"5398","DOI":"10.1182\/blood-2009-10-250803","volume":"115","author":"R Bruggen van","year":"2010","unstructured":"van Bruggen R, K\u00f6ker MY, Jansen M, van Houdt M, Roos D, Kuijpers TW, van den Berg TK (2010) Human NLRP3 inflammasome activation is Nox1-4 independent. Blood 115(26):5398\u20135400. doi: 10.1182\/blood-2009-10-250803","journal-title":"Blood"},{"issue":"8","key":"9242_CR85","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/ni.1631","volume":"9","author":"V Hornung","year":"2008","unstructured":"Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9(8):847\u2013856. doi: 10.1038\/ni.1631","journal-title":"Nat Immunol"},{"issue":"12","key":"9242_CR86","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1002\/eji.201243089","volume":"43","author":"ML Gabelloni","year":"2013","unstructured":"Gabelloni ML, Sabbione F, Jancic C, Fuxman Bass J, Keitelman I, Iula L, Oleastro M, Geffner JR et al (2013) NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1\u03b2 secretion but not in inflammasome activation. Eur J Immunol 43(12):3324\u20133335. doi: 10.1002\/eji.201243089","journal-title":"Eur J Immunol"},{"issue":"10","key":"9242_CR87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077794","volume":"8","author":"KF Hua","year":"2013","unstructured":"Hua KF, Yang SM, Kao TY, Chang JM, Chen HL, Tsai YJ, Chen A, Yang SS et al (2013) Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kappaB\/NLRP3 pathway. PLoS One 8(10), e77794. doi: 10.1371\/journal.pone.0077794","journal-title":"PLoS One"},{"issue":"4","key":"9242_CR88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002026","volume":"7","author":"Y Zheng","year":"2011","unstructured":"Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB (2011) A Yersinia effector with enhanced inhibitory activity on the NF-kappaB pathway activates the NLRP3\/ASC\/caspase-1 inflammasome in macrophages. PLoS Pathog 7(4), e1002026. doi: 10.1371\/journal.ppat.1002026","journal-title":"PLoS Pathog"},{"key":"9242_CR89","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fmicb.2011.00012","volume":"2","author":"PK Anand","year":"2011","unstructured":"Anand PK, Malireddi RK, Kanneganti TD (2011) Role of the NLRP3 inflammasome in microbial infection. Front Microbiol 2:12. doi: 10.3389\/fmicb.2011.00012","journal-title":"Front Microbiol"},{"issue":"4","key":"9242_CR90","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/ni.2231","volume":"13","author":"L Franchi","year":"2012","unstructured":"Franchi L, Munoz-Planillo R, Nunez G (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13(4):325\u2013332. doi: 10.1038\/ni.2231","journal-title":"Nat Immunol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9242-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9242-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9242-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9242-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T04:54:26Z","timestamp":1652504066000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-015-9242-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,20]]},"references-count":90,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["9242"],"URL":"https:\/\/doi.org\/10.1007\/s12035-015-9242-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,20]]}}}