{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:32:40Z","timestamp":1790015560764,"version":"4.0.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T00:00:00Z","timestamp":1449878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"UH-SGP","award":["2014"],"award-info":[{"award-number":["2014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s12035-015-9612-5","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T01:20:24Z","timestamp":1449883224000},"page":"6859-6868","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer\u2019s Disease Model"],"prefix":"10.1007","volume":"53","author":[{"given":"An T.","family":"Dao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munder A.","family":"Zagaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber T.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim A.","family":"Alkadhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,12]]},"reference":[{"key":"9612_CR1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.arcmed.2012.09.008","volume":"43","author":"KI Erickson","year":"2012","unstructured":"Erickson KI, Weinstein AM, Lopez OL (2012) Physical activity, brain plasticity, and Alzheimer\u2019s disease. Arch Med Res 43:615\u2013621","journal-title":"Arch Med Res"},{"key":"9612_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4236\/ami.2014.44006","volume":"4","author":"DC Matthews","year":"2014","unstructured":"Matthews DC, Davies M, Murray J, Williams S, Tsui WH, Li Y, Andrews RD, Lukic A, McHugh P, Vallabhajosula S, de Leon MJ, Mosconi L (2014) Physical activity, Mediterranean diet and biomarkers-assessed risk of Alzheimer\u2019s: a multi-modality brain imaging study. Adv J Mol Imaging 4:43\u201357","journal-title":"Adv J Mol Imaging"},{"key":"9612_CR3","doi-asserted-by":"crossref","first-page":"563160","DOI":"10.1155\/2014\/563160","volume":"2014","author":"T Murphy","year":"2014","unstructured":"Murphy T, Dias GP, Thuret S (2014) Effects of diet on brain plasticity in animal and human studies: mind the gap. Neural Plast 2014:563160","journal-title":"Neural Plast"},{"key":"9612_CR4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/1567205011310050006","volume":"10","author":"AT Dao","year":"2013","unstructured":"Dao AT, Zagaar MA, Levine AT, Salim S, Eriksen JL, Alkadhi KA (2013) Treadmill exercise prevents learning and memory impairment in Alzheimer\u2019s disease-like pathology. Curr Alzheimer Res 10:507\u2013515","journal-title":"Curr Alzheimer Res"},{"key":"9612_CR5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1017\/S1461145713001351","volume":"17","author":"AT Dao","year":"2014","unstructured":"Dao AT, Zagaar MA, Salim S, Eriksen JL, Alkadhi KA (2014) Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer\u2019s disease. Int J Neuropsychopharmacol 17:593\u2013602","journal-title":"Int J Neuropsychopharmacol"},{"key":"9612_CR6","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s12035-014-8916-1","volume":"52","author":"AT Dao","year":"2015","unstructured":"Dao AT, Zagaar MA, Alkadhi KA (2015) Moderate treadmill exercise protects synaptic plasticity of the dentate gyrus and related signaling cascade in a rat model of Alzheimer\u2019s disease. Mol Neurobiol 52:1067\u20131076","journal-title":"Mol Neurobiol"},{"key":"9612_CR7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0006-8993(78)90930-7","volume":"139","author":"DS Olton","year":"1978","unstructured":"Olton DS, Walker JA, Gage FH (1978) Hippocampal connections and spatial discrimination. Brain Res 139:295\u2013308","journal-title":"Brain Res"},{"key":"9612_CR8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1022519632041","volume":"31","author":"A Baba","year":"2002","unstructured":"Baba A, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y (2002) Different Ca2+ dynamics between isolated hippocampal pyramidal cells and dentate granule cells. J Neurocytol 31:41\u201348","journal-title":"J Neurocytol"},{"key":"9612_CR9","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.2174\/1871527313666140917115741","volume":"13","author":"F Bibi","year":"2014","unstructured":"Bibi F, Yasir M, Sohrab SS, Azhar EI, Al-Qahtani MH, Abuzenadah AM, Kamal MA, Naseer MI (2014) Link between chronic bacterial inflammation and Alzheimer disease. CNS Neurol Disord Drug Targets 13:1140\u20131147","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"9612_CR10","first-page":"152","volume":"24","author":"M Padurariu","year":"2012","unstructured":"Padurariu M, Ciobica A, Mavroudis I, Fotiou D, Baloyannis S (2012) Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer\u2019s disease patients. Psychiatr Danub 24:152\u2013158","journal-title":"Psychiatr Danub"},{"key":"9612_CR11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1471-4159.2011.07581.x","volume":"120","author":"B Sheng","year":"2012","unstructured":"Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X (2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer\u2019s disease. J Neurochem 120:419\u2013429","journal-title":"J Neurochem"},{"key":"9612_CR12","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","volume":"108","author":"KI Erickson","year":"2011","unstructured":"Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF (2011) Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 108:3017\u20133022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9612_CR13","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1038\/srep03457","volume":"3","author":"WD Killgore","year":"2013","unstructured":"Killgore WD, Olson EA, Weber M (2013) Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans. Sci Rep 3:3457","journal-title":"Sci Rep"},{"key":"9612_CR14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/83941","volume":"4","author":"J Mellor","year":"2001","unstructured":"Mellor J, Nicoll R (2001) Hippocampal mossy fiber LTP is independent of postsynaptic calcium. Nat Neurosci 4:125\u2013126","journal-title":"Nat Neurosci"},{"key":"9612_CR15","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neuro.2005.02.004","volume":"26","author":"ZA Bortolotto","year":"2005","unstructured":"Bortolotto ZA, Nistico R, More JC, Jane DE, Collingridge GL (2005) Kainate receptors and mossy fiber LTP. Neurotoxicology 26:769\u2013777","journal-title":"Neurotoxicology"},{"key":"9612_CR16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)61253-4","volume":"83","author":"G Lynch","year":"1990","unstructured":"Lynch G, Kessler M, Arai A, Larson J (1990) The nature and causes of hippocampal long-term potentiation. Prog Brain Res 83:233\u2013250","journal-title":"Prog Brain Res"},{"key":"9612_CR17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/345807a0","volume":"345","author":"WG Regehr","year":"1990","unstructured":"Regehr WG, Tank DW (1990) Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CA1 pyramidal cell dendrites. Nature 345:807\u2013810","journal-title":"Nature"},{"key":"9612_CR18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1101\/lm.6.5.399","volume":"6","author":"JD Sweatt","year":"1999","unstructured":"Sweatt JD (1999) Toward a molecular explanation for long-term potentiation. Learn Mem 6:399\u2013416","journal-title":"Learn Mem"},{"key":"9612_CR19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.nbd.2011.12.039","volume":"45","author":"M Zagaar","year":"2012","unstructured":"Zagaar M, Alhaider I, Dao A, Levine A, Alkarawi A, Alzubaidy M, Alkadhi K (2012) The beneficial effects of regular exercise on cognition in REM sleep deprivation: behavioral, electrophysiological and molecular evidence. Neurobiol Dis 45:1153\u20131162","journal-title":"Neurobiol Dis"},{"key":"9612_CR20","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neurobiolaging.2009.04.015","volume":"32","author":"M Srivareerat","year":"2011","unstructured":"Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA (2011) Chronic nicotine restores normal A\u03b2 levels and prevents short-term memory and E-LTP impairment in A\u03b2 rat model of Alzheimer\u2019s disease. Neurobiol Aging 32:834\u2013844","journal-title":"Neurobiol Aging"},{"key":"9612_CR21","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.nbd.2009.12.016","volume":"37","author":"TT Tran","year":"2010","unstructured":"Tran TT, Srivareerat M, Alkadhi KA (2010) Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer\u2019s disease. Neurobiol Dis 37:756\u2013763","journal-title":"Neurobiol Dis"},{"key":"9612_CR22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0304-3940(99)01002-2","volume":"279","author":"C Papatheodoropoulos","year":"2000","unstructured":"Papatheodoropoulos C, Kostopoulos G (2000) Decreased ability of rat temporal hippocampal CA1 region to produce long-term potentiation. Neurosci Lett 279:177\u2013180","journal-title":"Neurosci Lett"},{"key":"9612_CR23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-3-7091-0932-8_17","volume":"970","author":"CP Bengtson","year":"2012","unstructured":"Bengtson CP, Bading H (2012) Nuclear calcium signaling. Adv Exp Med Biol 970:377\u2013405","journal-title":"Adv Exp Med Biol"},{"key":"9612_CR24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/A:1009276932076","volume":"11","author":"KA Anderson","year":"1998","unstructured":"Anderson KA, Kane CD (1998) Ca2+\/calmodulin-dependent protein kinase IV and calcium signaling. Biometals 11:331\u2013343","journal-title":"Biometals"},{"key":"9612_CR25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2174\/157015909790031210","volume":"7","author":"K Ohira","year":"2009","unstructured":"Ohira K, Hayashi M (2009) A new aspect of the TrkB signaling pathway in neural plasticity. Curr Neuropharmacol 7:276\u2013285","journal-title":"Curr Neuropharmacol"},{"key":"9612_CR26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1254\/jjp.73.51","volume":"73","author":"A Nitta","year":"1997","unstructured":"Nitta A, Fukuta T, Hasegawa T, Nabeshima T (1997) Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration. Jpn J Pharmacol 73:51\u201357","journal-title":"Jpn J Pharmacol"},{"key":"9612_CR27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0304-3940(94)90239-9","volume":"170","author":"A Nitta","year":"1994","unstructured":"Nitta A, Itoh A, Hasegawa T, Nabeshima T (1994) Beta-amyloid protein-induced Alzheimer\u2019s disease animal model. Neurosci Lett 170:63\u201366","journal-title":"Neurosci Lett"},{"key":"9612_CR28","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1046\/j.1471-4159.1996.66031113.x","volume":"66","author":"A Itoh","year":"1996","unstructured":"Itoh A, Nitta A, Nadai M, Nishimura K, Hirose M, Hasegawa T, Nabeshima T (1996) Dysfunction of cholinergic and dopaminergic neuronal systems in beta-amyloid protein-infused rats. J Neurochem 66:1113\u20131117","journal-title":"J Neurochem"},{"key":"9612_CR29","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.biopsych.2008.08.021","volume":"65","author":"M Srivareerat","year":"2009","unstructured":"Srivareerat M, Tran TT, Alzoubi KH, Alkadhi KA (2009) Chronic psychosocial stress exacerbates impairment of cognition and long-term potentiation in beta-amyloid rat model of Alzheimer\u2019s disease. Biol Psychiatry 65:918\u2013926","journal-title":"Biol Psychiatry"},{"key":"9612_CR30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1089\/scd.2012.0345","volume":"22","author":"D Darlington","year":"2013","unstructured":"Darlington D, Deng J, Giunta B, Hou H, Sanberg CD, Kuzmin-Nichols N, Zhou HD, Mori T, Ehrhart J, Sanberg PR, Tan J (2013) Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-beta-associated neuropathology in Alzheimer mice. Stem Cells Dev 22:412\u2013421","journal-title":"Stem Cells Dev"},{"key":"9612_CR31","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1007\/s12035-013-8401-2","volume":"47","author":"RL Frozza","year":"2013","unstructured":"Frozza RL, Bernardi A, Hoppe JB, Meneghetti AB, Matte A, Battastini AM, Pohlmann AR, Guterres SS, Salbego C (2013) Neuroprotective effects of resveratrol against Abeta administration in rats are improved by lipid-core nanocapsules. Mol Neurobiol 47:1066\u20131080","journal-title":"Mol Neurobiol"},{"key":"9612_CR32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1471-4159.2009.06450.x","volume":"112","author":"X Sun","year":"2010","unstructured":"Sun X, Yao H, Douglas RM, Gu XQ, Wang J, Haddad GG (2010) Insulin\/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic slice cultures. J Neurochem 112:377\u2013388","journal-title":"J Neurochem"},{"key":"9612_CR33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2302\/kjm.2012-0005-RE","volume":"62","author":"M Sawada","year":"2013","unstructured":"Sawada M, Sawamoto K (2013) Mechanisms of neurogenesis in the normal and injured adult brain. Keio J Med 62:13\u201328","journal-title":"Keio J Med"},{"key":"9612_CR34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5483\/BMBRep.2009.42.5.239","volume":"42","author":"E Lee","year":"2009","unstructured":"Lee E, Son H (2009) Adult hippocampal neurogenesis and related neurotrophic factors. BMB Rep 42:239\u2013244","journal-title":"BMB Rep"},{"key":"9612_CR35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuroscience.2015.03.006","volume":"309","author":"EJ Mufson","year":"2015","unstructured":"Mufson EJ, Mahady L, Waters D, Counts SE, Perez SE, DeKosky S, Ginsberg SD, Ikonomovic MD, Scheff S, Binder L (2015) Hippocampal plasticity during the progression of Alzheimer\u2019s disease. Neuroscience 309:51\u201367","journal-title":"Neuroscience"},{"key":"9612_CR36","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1093\/brain\/awn174","volume":"131","author":"NW Hu","year":"2008","unstructured":"Hu NW, Smith IM, Walsh DM, Rowan MJ (2008) Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain 131:2414\u20132424","journal-title":"Brain"},{"key":"9612_CR37","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1523\/JNEUROSCI.0204-08.2008","volume":"28","author":"N Origlia","year":"2008","unstructured":"Origlia N, Righi M, Capsoni S, Cattaneo A, Fang F, Stern DM, Chen JX, Schmidt AM, Arancio O, Yan SD, Domenici L (2008) Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. J Neurosci 28:3521\u20133530","journal-title":"J Neurosci"},{"key":"9612_CR38","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.neurobiolaging.2007.03.018","volume":"29","author":"Q Wang","year":"2008","unstructured":"Wang Q, Klyubin I, Wright S, Griswold-Prenner I, Rowan MJ, Anwyl R (2008) Alpha v integrins mediate beta-amyloid induced inhibition of long-term potentiation. Neurobiol Aging 29:1485\u20131493","journal-title":"Neurobiol Aging"},{"key":"9612_CR39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neures.2013.08.005","volume":"77","author":"T Isono","year":"2013","unstructured":"Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y (2013) Amyloid-beta 25-35 induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2. Neurosci Res 77:180\u2013185","journal-title":"Neurosci Res"},{"key":"9612_CR40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-2012-120394","volume":"32","author":"M Kervern","year":"2012","unstructured":"Kervern M, Angeli A, Nicole O, Leveille F, Parent B, Villette V, Buisson A, Dutar P (2012) Selective impairment of some forms of synaptic plasticity by oligomeric amyloid-beta peptide in the mouse hippocampus: implication of extrasynaptic NMDA receptors. J Alzheimers Dis 32:183\u2013196","journal-title":"J Alzheimers Dis"},{"key":"9612_CR41","doi-asserted-by":"crossref","first-page":"17941","DOI":"10.1074\/jbc.M601372200","volume":"281","author":"SM Huang","year":"2006","unstructured":"Huang SM, Mouri A, Kokubo H, Nakajima R, Suemoto T, Higuchi M, Staufenbiel M, Noda Y, Yamaguchi H, Nabeshima T, Saido TC, Iwata N (2006) Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem 281:17941\u201317951","journal-title":"J Biol Chem"},{"key":"9612_CR42","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/jnc.12728","volume":"130","author":"Y Kuwabara","year":"2014","unstructured":"Kuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima T (2014) Impairments of long-term depression induction and motor coordination precede Abeta accumulation in the cerebellum of APPswe\/PS1dE9 double transgenic mice. J Neurochem 130:432\u2013443","journal-title":"J Neurochem"},{"key":"9612_CR43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbr.2013.02.018","volume":"245","author":"RG Bechara","year":"2013","unstructured":"Bechara RG, Kelly AM (2013) Exercise improves object recognition memory and induces BDNF expression and cell proliferation in cognitively enriched rats. Behav Brain Res 245:96\u2013100","journal-title":"Behav Brain Res"},{"key":"9612_CR44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuroscience.2011.11.029","volume":"202","author":"RC Cassilhas","year":"2012","unstructured":"Cassilhas RC, Lee KS, Fernandes J, Oliveira MG, Tufik S, Meeusen R, de Mello MT (2012) Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience 202:309\u2013317","journal-title":"Neuroscience"},{"key":"9612_CR45","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuropharm.2013.04.002","volume":"76 Pt C","author":"NN Karpova","year":"2014","unstructured":"Karpova NN (2014) Role of BDNF epigenetics in activity-dependent neuronal plasticity. Neuropharmacology 76 Pt C:709\u2013718","journal-title":"Neuropharmacology"},{"key":"9612_CR46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pbb.2014.09.009","volume":"126","author":"BY Wang","year":"2014","unstructured":"Wang BY, Zhong Y, Zhao Z, Miao Y (2014) Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacol Biochem Behav 126:83\u201389","journal-title":"Pharmacol Biochem Behav"},{"key":"9612_CR47","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijdevneu.2012.11.002","volume":"31","author":"JL Abel","year":"2013","unstructured":"Abel JL, Rissman EF (2013) Running-induced epigenetic and gene expression changes in the adolescent brain. Int J Dev Neurosci 31:382\u2013390","journal-title":"Int J Dev Neurosci"},{"key":"9612_CR48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1460-9568.2010.07508.x","volume":"33","author":"F Gomez-Pinilla","year":"2011","unstructured":"Gomez-Pinilla F, Zhuang Y, Feng J, Ying Z, Fan G (2011) Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. Eur J Neurosci 33:383\u2013390","journal-title":"Eur J Neurosci"},{"key":"9612_CR49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","volume":"35","author":"BE Lonze","year":"2002","unstructured":"Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605\u2013623","journal-title":"Neuron"},{"key":"9612_CR50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1750-1326-6-60","volume":"6","author":"S Pugazhenthi","year":"2011","unstructured":"Pugazhenthi S, Wang M, Pham S, Sze CI, Eckman CB (2011) Downregulation of CREB expression in Alzheimer\u2019s brain and in Abeta-treated rat hippocampal neurons. Mol Neurodegener 6:60","journal-title":"Mol Neurodegener"},{"issue":"2","key":"9612_CR51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/hmg\/ddr492","volume":"21","author":"MC Ljungberg","year":"2012","unstructured":"Ljungberg MC, Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC (2012) CREB-activity and NMNAT2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 21(2):251\u2013267","journal-title":"Hum Mol Genet"},{"key":"9612_CR52","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1093\/nar\/gks1227","volume":"41","author":"N Jin","year":"2013","unstructured":"Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F (2013) CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer\u2019s disease. Nucleic Acids Res 41:3240\u20133256","journal-title":"Nucleic Acids Res"},{"key":"9612_CR53","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/jcp.21902","volume":"221","author":"MS Arrazola","year":"2009","unstructured":"Arrazola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, Gonzalez M, Montecino M, Maass A, Martinez S, Inestrosa NC (2009) Calcium\/calmodulin-dependent protein kinase type IV is a target gene of the Wnt\/beta-catenin signaling pathway. J Cell Physiol 221:658\u2013667","journal-title":"J Cell Physiol"},{"key":"9612_CR54","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nlm.2014.12.005","volume":"118","author":"TW Lin","year":"2015","unstructured":"Lin TW, Shih YH, Chen SJ, Lien CH, Chang CY, Huang TY, Chen SH, Jen CJ, Kuo YM (2015) Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer\u2019s disease (APP\/PS1) transgenic mice. Neurobiol Learn Mem 118:189\u2013197","journal-title":"Neurobiol Learn Mem"}],"updated-by":[{"DOI":"10.1007\/s12035-017-0790-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000}}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9612-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9612-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9612-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9612-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T11:14:54Z","timestamp":1567422894000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-015-9612-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,12]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["9612"],"URL":"https:\/\/doi.org\/10.1007\/s12035-015-9612-5","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12035-017-0790-1","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,12]]}}}