{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:11:03Z","timestamp":1791198663149,"version":"4.1.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"CNPq (Casadinho\/PROCAD).","award":["479526\/2012-5"],"award-info":[{"award-number":["479526\/2012-5"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s12035-015-9617-0","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T07:06:28Z","timestamp":1450163188000},"page":"6997-7009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Indoleamine-2,3-Dioxygenase\/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes"],"prefix":"10.1007","volume":"53","author":[{"given":"Isabella Caroline","family":"da Silva Dias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Carabelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Kaori","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"de Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene Cristina","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz E.","family":"Rizzo de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio M.","family":"Zanata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Lira","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Mattar","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anete Curte","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joice Maria","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaina Menezes","family":"Zanoveli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"issue":"3","key":"9617_CR1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11011-010-9211-0","volume":"25","author":"CA Wayhs","year":"2010","unstructured":"Wayhs CA, Manfredini V, Sitta A, Deon M, Ribas G, Vanzin C, Biancini G, Ferri M et al (2010) Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect. Metab Brain Dis 25(3):297\u2013304","journal-title":"Metab Brain Dis"},{"issue":"5","key":"9617_CR2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0031-9384(91)90424-M","volume":"50","author":"LL Bellush","year":"1991","unstructured":"Bellush LL, Reid SG, North D (1991) The functional significance of biochemical alterations in streptozotocin-induced diabetes. Physiol Behav 50(5):973\u201381","journal-title":"Physiol Behav"},{"issue":"Suppl 1","key":"9617_CR3","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1002\/dmrr.848","volume":"24","author":"J Apelqvist","year":"2008","unstructured":"Apelqvist J, Bakker K, van Houtum WH, Schaper NC (2008) International Working Group on the Diabetic Foot (IWGDF) Editorial Board. Practical guidelines on the management and prevention of the diabetic foot: based upon the International Consensus on the Diabetic Foot (2007) Prepared by the International Working Group on the Diabetic Foot. Diabetes Metab Res Rev 24(Suppl 1):S181\u20137","journal-title":"Diabetes Metab Res Rev"},{"key":"9617_CR4","unstructured":"International Diabetes Federation (2014) Diabetes: facts and figures http:\/\/www.idf.org\/worlddiabetesday\/toolkit\/gp\/facts-figures . Accessed 30 May 2015"},{"issue":"2","key":"9617_CR5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jchf.2014.08.004","volume":"3","author":"A Dei Cas","year":"2015","unstructured":"Dei Cas A, Khan SS, Butler J, Mentz RJ, Bonow RO, Avogaro A, Tschoepe D, Doehner W et al (2015) Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure. JACC Heart Fail 3(2):136\u201345","journal-title":"JACC Heart Fail"},{"issue":"6","key":"9617_CR6","doi-asserted-by":"crossref","first-page":"e0128359","DOI":"10.1371\/journal.pone.0128359","volume":"10","author":"K Monaghan","year":"2015","unstructured":"Monaghan K, McNaughten J, McGahon MK, Kelly C, Kyle D, Yong PH, McGeown JG, Curtis TM (2015) Hyperglycemia and diabetes downregulate the functional expression of TRPV4 channels in retinal microvascular endothelium. PLoS One 10(6):e0128359","journal-title":"PLoS One"},{"issue":"3","key":"9617_CR7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4239\/wjd.v6.i3.432","volume":"6","author":"AK Schreiber","year":"2015","unstructured":"Schreiber AK, Nones CF, Reis RC, Chichorro JG, Cunha JM (2015) Diabetic neuropathic pain: physiopathology and treatment. World J Diabetes 6(3):432\u201344","journal-title":"World J Diabetes"},{"issue":"6","key":"9617_CR8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S2213-8587(15)00134-5","volume":"3","author":"CD Moulton","year":"2015","unstructured":"Moulton CD, Pickup JC, Ismail K (2015) The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol 3(6):461\u2013471","journal-title":"Lancet Diabetes Endocrinol"},{"key":"9617_CR9","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2337\/diacare.24.6.1069","volume":"24","author":"RJ Anderson","year":"2001","unstructured":"Anderson RJ, Freedland KE, Clouse RE, Lustman PJ (2001) The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 24:1069\u201378","journal-title":"Diabetes Care"},{"issue":"23","key":"9617_CR10","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1001\/jama.299.23.2751","volume":"299","author":"SH Golden","year":"2008","unstructured":"Golden SH, Lazo M, Carnethon M, Bertoni AG, Schreiner PJ, Diez Roux AV, Lee HB, Lyketsos C (2008) Examining a bidirectional association between depressive symptoms and diabetes. JAMA 299(23):2751\u20139","journal-title":"JAMA"},{"issue":"1","key":"9617_CR11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4088\/JCP.12r07922","volume":"74","author":"F Rotella","year":"2013","unstructured":"Rotella F, Mannucci E (2013) Depression as a risk factor for diabetes: a meta-analysis of longitudinal studies. J Clin Psychiatry 74(1):31\u20137","journal-title":"J Clin Psychiatry"},{"key":"9617_CR12","unstructured":"Zanoveli JM, de Morais H, da Silva Dias IC, Schreiber AK, de Souza CP, da Cunha JM (2015) Depression associated with diabetes: from pathophysiology to treatment. Curr Diabetes Rev"},{"key":"9617_CR13","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington","edition":"5"},{"issue":"Suppl","key":"9617_CR14","first-page":"18","volume":"55","author":"LL Judd","year":"1994","unstructured":"Judd LL, Rapaport MH, Paulus MP, Brown JL (1994) Subsyndromal symptomatic depression: a new mood disorder? J Clin Psychiatry 55(Suppl):18\u201328","journal-title":"J Clin Psychiatry"},{"issue":"2","key":"9617_CR15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0091-3057(00)00221-5","volume":"66","author":"R Gomez","year":"2000","unstructured":"Gomez R, Barros HM (2000) Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats. Pharmacol Biochem Behav 66(2):329\u201335","journal-title":"Pharmacol Biochem Behav"},{"key":"9617_CR16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2007.03.088","volume":"1154","author":"HA Silva da","year":"2007","unstructured":"da Silva HA, Sitta A, Barschak AG, Deon M, Barden AT, Schmitt GO, Landgraff S, Gomez R et al (2007) Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. Brain Res 1154:137\u201343","journal-title":"Brain Res"},{"issue":"4","key":"9617_CR17","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11011-013-9397-z","volume":"28","author":"CA Wayhs","year":"2013","unstructured":"Wayhs CA, Mescka CP, Vanzin CS, Ribas GS, Guerreiro G, Nin MS, Manfredini V, Barros HM et al (2013) Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior. Metab Brain Dis 28(4):563\u201370","journal-title":"Metab Brain Dis"},{"key":"9617_CR18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbr.2013.10.011","volume":"258","author":"H Morais de","year":"2014","unstructured":"de Morais H, de Souza CP, da Silva LM, Ferreira DM, Werner MF, Andreatini R, da Cunha JM, Zanoveli JM (2014) Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats. Behav Brain Res 258:52\u201364","journal-title":"Behav Brain Res"},{"issue":"8","key":"9617_CR19","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cpr.2011.08.001","volume":"31","author":"BN Renn","year":"2011","unstructured":"Renn BN, Feliciano L, Segal DL (2011) The bidirectional relationship of depression and diabetes: a systematic review. Clin Psychol Rev 31(8):1239\u201346","journal-title":"Clin Psychol Rev"},{"issue":"7","key":"9617_CR20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/PSY.0000000000000082","volume":"76","author":"P Demakakos","year":"2014","unstructured":"Demakakos P, Zaninotto P, Nouwen A (2014) Is the association between depressive symptoms and glucose metabolism bidirectional? Evidence from the English Longitudinal Study of Ageing. Psychosom Med 76(7):555\u201361","journal-title":"Psychosom Med"},{"issue":"2","key":"9617_CR21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbi.2006.09.006","volume":"21","author":"R Dantzer","year":"2007","unstructured":"Dantzer R, Kelley KW (2007) Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 21(2):153\u201360","journal-title":"Brain Behav Immun"},{"issue":"1","key":"9617_CR22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","volume":"37","author":"E Haroon","year":"2012","unstructured":"Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37(1):137\u201362","journal-title":"Neuropsychopharmacology"},{"key":"9617_CR23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pnpbp.2013.10.018","volume":"48","author":"BE Leonard","year":"2014","unstructured":"Leonard BE (2014) Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 48:261\u20137","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"12","key":"9617_CR24","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.2337\/dc11-2329","volume":"35","author":"KK Hood","year":"2012","unstructured":"Hood KK, Lawrence JM, Anderson A, Bell R, Dabelea D, Daniels S, Rodriguez B, Dolan LM (2012) Metabolic and inflammatory links to depression in youth with diabetes. Diabetes Care 35(12):2443\u20136","journal-title":"Diabetes Care"},{"issue":"6","key":"9617_CR25","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4239\/wjd.v5.i6.796","volume":"5","author":"BH Chew","year":"2014","unstructured":"Chew BH, Shariff-Ghazali S, Fernandez A (2014) Psychological aspects of diabetes care: effecting behavioral change in patients. World J Diabetes 5(6):796\u2013808","journal-title":"World J Diabetes"},{"issue":"4","key":"9617_CR26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4239\/wjd.v6.i4.554","volume":"6","author":"CA Downs","year":"2015","unstructured":"Downs CA, Faulkner MS (2015) Toxic stress, inflammation and symptomatology of chronic complications in diabetes. World J Diabetes 6(4):554\u201365","journal-title":"World J Diabetes"},{"issue":"1","key":"9617_CR27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, O\u2019Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46\u201356","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"9617_CR28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrneurol.2011.137","volume":"7","author":"AM Vincent","year":"2011","unstructured":"Vincent AM, Callaghan BC, Smith AL, Feldman EL (2011) Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol 7(10):573\u201383","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"9617_CR29","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3233\/JAD-2011-111097","volume":"28","author":"N Dobos","year":"2012","unstructured":"Dobos N, de Vries EF, Kema IP, Patas K, Prins M, Nijholt IM, Dierckx RA, Korf J et al (2012) The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. J Alzheimers Dis 28(4):905\u201315","journal-title":"J Alzheimers Dis"},{"issue":"2\u20133","key":"9617_CR30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.psychres.2011.09.029","volume":"196","author":"M Maes","year":"2012","unstructured":"Maes M, Rief W (2012) Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway. Psychiatry Res 196(2\u20133):243\u20139","journal-title":"Psychiatry Res"},{"issue":"3","key":"9617_CR31","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.pnpbp.2010.06.014","volume":"35","author":"M Maes","year":"2011","unstructured":"Maes M (2011) Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry 35(3):664\u201375","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"9617_CR32","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.pnpbp.2010.12.017","volume":"35","author":"M Maes","year":"2011","unstructured":"Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R (2011) The new \u20185-HT\u2019 hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry 35(3):702\u201321","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"9617_CR33","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pnpbp.2007.09.004","volume":"32","author":"M Molina-Hern\u00e1ndez","year":"2008","unstructured":"Molina-Hern\u00e1ndez M, Tellez-Alc\u00e1ntara NP, P\u00e9rez-Garc\u00eda J, Olivera-Lopez JI, Jaramillo-Jaimes MT (2008) Antidepressant-like actions of minocycline combined with several glutamate antagonists. Prog Neuropsychopharmacol Biol Psychiatry 32(2):380\u20136","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"9617_CR34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pbb.2014.07.002","volume":"124","author":"XT Guan","year":"2014","unstructured":"Guan XT, Shao F, Xie X, Chen L, Wang W (2014) Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: comparison to fluoxetine and imipramine. Pharmacol Biochem Behav 124:361\u20136","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"9617_CR35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12640-014-9467-y","volume":"26","author":"T Zaminelli","year":"2014","unstructured":"Zaminelli T, Gradowski RW, Bassani TB, Barbiero JK, Santiago RM, Maria-Ferreira D, Baggio CH, Vital MA (2014) Antidepressant and antioxidative effect of Ibuprofen in the rotenone model of Parkinson\u2019s disease. Neurotox Res 26(4):351\u201362","journal-title":"Neurotox Res"},{"issue":"5604","key":"9617_CR36","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266(5604):730\u20132","journal-title":"Nature"},{"issue":"1","key":"9617_CR37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","volume":"121","author":"MJ Detke","year":"1995","unstructured":"Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 121(1):66\u201372","journal-title":"Psychopharmacology (Berl)"},{"issue":"4\u20135","key":"9617_CR38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","volume":"29","author":"JF Cryan","year":"2005","unstructured":"Cryan JF, Valentino RJ, Lucki I (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29(4\u20135):547\u201369","journal-title":"Neurosci Biobehav Rev"},{"issue":"12","key":"9617_CR39","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1590\/S0100-879X2005001200014","volume":"38","author":"MC Carvalho","year":"2005","unstructured":"Carvalho MC, Albrechet-Souza L, Masson S, Brand\u00e3o ML (2005) Changes in the biogenic amine content of the prefrontal cortex, amygdala, dorsal hippocampus, and nucleus accumbens of rats submitted to single and repeated sessions of the elevated plus-maze test. Braz J Med Biol Res 38(12):1857\u201366","journal-title":"Braz J Med Biol Res"},{"key":"9617_CR40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u201354","journal-title":"Anal Biochem"},{"issue":"5","key":"9617_CR41","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.3390\/ijms15057667","volume":"15","author":"XY Mao","year":"2014","unstructured":"Mao XY, Cao DF, Li X, Yin JY, Wang ZB, Zhang Y, Mao CX, Zhou HH et al (2014) Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Int J Mol Sci 15(5):7667\u201383","journal-title":"Int J Mol Sci"},{"issue":"1\u20132","key":"9617_CR42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jneuroim.2014.01.013","volume":"269","author":"A Dey","year":"2014","unstructured":"Dey A, Hao S, Erion JR, Wosiski-Kuhn M, Stranahan AM (2014) Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes.J. Neuroimmunol 269(1\u20132):20\u20137","journal-title":"Neuroimmunol"},{"key":"9617_CR43","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuroscience.2014.05.042","volume":"274","author":"RH Yang","year":"2014","unstructured":"Yang RH, Lin J, Hou XH, Cao R, Yu F, Liu HQ, Ji AL, Xu XN et al (2014) Effect of docosahexaenoic acid on hippocampal neurons in high-glucose condition: involvement of PI3K\/AKT\/nuclear factor-\u03baB-mediated inflammatory pathways. Neuroscience 274:218\u201328","journal-title":"Neuroscience"},{"issue":"9","key":"9617_CR44","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1179\/1743132814Y.0000000330","volume":"36","author":"IK Hwang","year":"2014","unstructured":"Hwang IK, Choi JH, Nam SM, Park OK, Yoo DY, Kim W, Yi SS, Won MH et al (2014) Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats. Neurol Res 36(9):824\u201332","journal-title":"Neurol Res"},{"issue":"6","key":"9617_CR45","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","volume":"110","author":"K Maedler","year":"2002","unstructured":"Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA et al (2002) Glucose-induced \u03b2 cell production of IL-1\u03b2 contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110(6):851\u201360","journal-title":"J Clin Invest"},{"issue":"12","key":"9617_CR46","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1073\/pnas.122686299","volume":"99","author":"K Maedler","year":"2002","unstructured":"Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F et al (2002) FLIP switches Fas-mediated glucose signaling in human pancreatic \u03b2 cells from apoptosis to cell replication. Proc Natl Acad Sci U S A 99(12):8236\u201341","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl 3","key":"9617_CR47","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.2337\/diabetes.53.suppl_3.S97","volume":"53","author":"B Emanuelli","year":"2004","unstructured":"Emanuelli B, Glondu M, Filloux C, Peraldi P, Van Obberghen E (2004) The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells. Diabetes 53(Suppl 3):S97\u2013S103","journal-title":"Diabetes"},{"key":"9617_CR48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-511X-8-25","volume":"8","author":"EK Vassiliou","year":"2009","unstructured":"Vassiliou EK, Gonzalez A, Garcia C, Tadros JH, Chakraborty G, Toney JH (2009) Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-alpha both in vitro and in vivo systems. Lipids Health Dis 8:25","journal-title":"Lipids Health Dis"},{"issue":"9","key":"9617_CR49","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1074\/jbc.M114.624759","volume":"290","author":"Y Ando","year":"2015","unstructured":"Ando Y, Shinozawa Y, Iijima Y, Yu BC, Sone M, Ooi Y, Watanaka Y, Chida K et al (2015) Tumor necrosis factor (TNF)-\u03b1-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-I\u03b1 causes insulin resistance in 3T3-L1 adipocytes. J Biol Chem 290(9):5881\u201392","journal-title":"J Biol Chem"},{"issue":"6","key":"9617_CR50","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/pr.2012.24","volume":"71","author":"EK Grishman","year":"2012","unstructured":"Grishman EK, White PC, Savani RC (2012) Toll-like receptors, the NLRP3 inflammasome, and interleukin-1\u03b2 in the development and progression of type 1 diabetes. Pediatr Res 71(6):626\u201332","journal-title":"Pediatr Res"},{"issue":"5","key":"9617_CR51","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","volume":"23","author":"JF Cryan","year":"2002","unstructured":"Cryan JF, Markou A, Lucki I (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23(5):238\u201345","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"9617_CR52","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","volume":"7","author":"DA Slattery","year":"2012","unstructured":"Slattery DA, Cryan JF (2012) Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc 7(6):1009\u201314","journal-title":"Nat Protoc"},{"issue":"1\u20132","key":"9617_CR53","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresbull.2005.06.001","volume":"67","author":"R Ramakrishnan","year":"2005","unstructured":"Ramakrishnan R, Sheeladevi R, Suthanthirarajan N, Namasivayam A (2005) An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-\u03b1 expression in rat brain. Brain Res Bull 67(1\u20132):46\u201352","journal-title":"Brain Res Bull"},{"key":"9617_CR54","doi-asserted-by":"crossref","first-page":"238780","DOI":"10.1155\/2014\/238780","volume":"2014","author":"E Ezzeldin","year":"2014","unstructured":"Ezzeldin E, Souror WA, El-Nahhas T, Soudi AN, Shahat AA (2014) Biochemical and neurotransmitters changes associated with tramadol in streptozotocin-induced diabetes in rats. Biomed Res Int 2014:238780","journal-title":"Biomed Res Int"},{"issue":"4","key":"9617_CR55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/FBP.0b013e328308f1d6","volume":"19","author":"JX Li","year":"2008","unstructured":"Li JX, France CP (2008) Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats. Behav Pharmacol 19(4):292\u20137","journal-title":"Behav Pharmacol"},{"issue":"6","key":"9617_CR56","first-page":"311","volume":"61","author":"Y Umeda","year":"2007","unstructured":"Umeda Y, Amano M, Suemaru K, Yamaguchi T, Kitamura Y, Gomita Y, Kawasaki H, Araki H (2007) The Influence of hyperactivity of the hypothalamic-pituitary-adrenal axis and hyperglycemia on the 5-HT2A receptor-mediated wet-dog shake responses in rats. Acta Med Okayama 61(6):311\u20137","journal-title":"Acta Med Okayama"},{"issue":"6","key":"9617_CR57","first-page":"805","volume":"106","author":"C Montigny de","year":"1977","unstructured":"de Montigny C (1977) Neurophysiology and current trends in research on depression. Remarks on the monoaminergic hypothesis of depression. Union Med Can 106(6):805\u201310","journal-title":"Union Med Can"},{"issue":"Suppl 6","key":"9617_CR58","first-page":"7","volume":"61","author":"PL Delgado","year":"2000","unstructured":"Delgado PL (2000) Depression: the case for a monoamine deficiency. J Clin Psychiatry 61(Suppl 6):7\u201311","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"9617_CR59","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/0253-7613.150305","volume":"47","author":"V Prabhakar","year":"2015","unstructured":"Prabhakar V, Gupta D, Kanade P, Radhakrishnan M (2015) Diabetes-associated depression: the serotonergic system as a novel multifunctional target. Indian J Pharmacol 47(1):4\u201310","journal-title":"Indian J Pharmacol"},{"key":"9617_CR60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbi.2012.08.008","volume":"31","author":"AW Corona","year":"2013","unstructured":"Corona AW, Norden DM, Skendelas JP, Huang Y, O\u2019Connor JC, Lawson M, Dantzer R, Kelley KW et al (2013) Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice. Brain Behav Immun 31:134\u201342","journal-title":"Brain Behav Immun"},{"issue":"3","key":"9617_CR61","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.yhbeh.2012.03.010","volume":"62","author":"A Salazar","year":"2012","unstructured":"Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O\u2019Connor JC (2012) Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge. Horm Behav 62(3):202\u20139","journal-title":"Horm Behav"},{"issue":"10","key":"9617_CR62","first-page":"87","volume":"18","author":"MA Lawson","year":"2013","unstructured":"Lawson MA, Parrott JM, McCusker RH, Dantzer R, Kelley KW, O\u2019Connor JC (2013) Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors. J Neuroinflammation 18(10):87","journal-title":"J Neuroinflammation"},{"key":"9617_CR63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1742-2094-11-41","volume":"11","author":"W Xie","year":"2014","unstructured":"Xie W, Cai L, Yu Y, Gao L, Xiao L, He Q, Ren Z, Liu Y (2014) Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy. J Neuroinflammation 11:41","journal-title":"J Neuroinflammation"},{"key":"9617_CR64","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF02980066","volume":"27","author":"SS Kim","year":"2004","unstructured":"Kim SS, Kong PJ, Kim BS, Sheen DH, Nam SY, Chun W (2004) Inhibitory action of minocycline on lipopolysaccharide induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Arch Pharm Res 27:314\u2013318","journal-title":"Arch Pharm Res"},{"key":"9617_CR65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainres.2005.02.062","volume":"1044","author":"N Morimoto","year":"2005","unstructured":"Morimoto N, Shimazawa M, Yamashima T, Nagai H, Hara H (2005) Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res 1044:8\u201315","journal-title":"Brain Res"},{"key":"9617_CR66","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tox.2007.11.003","volume":"244","author":"M Ahuja","year":"2008","unstructured":"Ahuja M, Bishnoi M, Chopra K (2008) Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology 244:111\u2013122","journal-title":"Toxicology"},{"key":"9617_CR67","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2009.07.031","volume":"1291","author":"S Homsi","year":"2009","unstructured":"Homsi S, Federico F, Croci N, Palmier B, Plotkine M, Marchand-Leroux C, Jafarian-Tehrani M (2009) Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice. Brain Res 1291:122\u201332","journal-title":"Brain Res"},{"key":"9617_CR68","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12640-009-9120-3","volume":"18","author":"L Orio","year":"2010","unstructured":"Orio L, Llopis N, Torres E, Izco M, O\u2019Shea E, Colado MI (2010) A study on the mechanisms by which minocycline protects against MDMA (\u2018ecstasy\u2019)-induced neurotoxicity of 5-HT cortical neurons. Neurotox Res 18:187\u2013199","journal-title":"Neurotox Res"},{"key":"9617_CR69","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2165\/11632000-000000000-00000","volume":"26","author":"OM Dean","year":"2012","unstructured":"Dean OM, Data-Franco J, Giorlando F, Berk M (2012) Minocycline: therapeutic potential in psychiatry. CNS Drugs 26:391\u2013401","journal-title":"CNS Drugs"},{"key":"9617_CR70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-2094-5-15","volume":"5","author":"CJ Henry","year":"2008","unstructured":"Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, Sheridan JF, Godbout JP (2008) Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior and anhedonia. J Neuroinflammation 5:15","journal-title":"J Neuroinflammation"},{"issue":"3","key":"9617_CR71","doi-asserted-by":"crossref","first-page":"180","DOI":"10.9758\/cpn.2014.12.3.180","volume":"12","author":"OM Dean","year":"2014","unstructured":"Dean OM, Maes M, Ashton M, Berk L, Kanchanatawan B, Sughondhabirom A, Tangwongchai S, Ng C et al (2014) Protocol and rationale\u2014the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial. Clin Psychopharmacol Neurosci 12(3):180\u2013188","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"9617_CR72","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pbb.2013.11.027","volume":"117","author":"YW Liu","year":"2014","unstructured":"Liu YW, Zhu X, Zhang L, Lu Q, Zhang F, Guo H, Yin XX (2014) Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. Pharmacol Biochem Behav 117:128\u201336","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"9617_CR73","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.neuropharm.2011.04.033","volume":"61","author":"D Liu","year":"2011","unstructured":"Liu D, Wang Z, Liu S, Wang F, Zhao S, Hao A (2011) Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells. Neuropharmacology 61(4):592\u20139","journal-title":"Neuropharmacology"},{"issue":"1","key":"9617_CR74","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pharep.2013.08.002","volume":"66","author":"E Obuchowicz","year":"2014","unstructured":"Obuchowicz E, Bielecka AM, Paul-Samojedny M, Pude\u0142ko A, Kowalski J (2014) Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture. Pharmacol Rep 66(1):34\u201343","journal-title":"Pharmacol Rep"},{"key":"9617_CR75","doi-asserted-by":"crossref","unstructured":"Oxenkrug G, Ratner R, Summergrad P (2013) Kynurenines and vitamin B6: link between diabetes and depression. J Bioinform Diabetes. 1(1).","DOI":"10.14302\/issn.2374-9431.jbd-13-218"},{"issue":"1","key":"9617_CR76","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","volume":"32","author":"P Belenky","year":"2007","unstructured":"Belenky P, Bogan KL, Brenner C (2007) NAD+ metabolism in health and disease. Trends Biochem Sci 32(1):12\u20139","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"9617_CR77","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0885-4505(86)90111-8","volume":"36","author":"KS Rogers","year":"1986","unstructured":"Rogers KS, Higgins ES, Kline ES (1986) Experimental diabetes causes mitochondrial loss and cytoplasmic enrichment of pyridoxal phosphate and aspartate aminotransferase activity. Biochem Med Metab Biol 36(1):91\u20137","journal-title":"Biochem Med Metab Biol"},{"issue":"2","key":"9617_CR78","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11011-010-9194-x","volume":"25","author":"B Tagliari","year":"2010","unstructured":"Tagliari B, Noschang CG, Ferreira AG, Ferrari OA, Feksa LR, Wannmacher CM, Dalmaz C, Wyse AT (2010) Chronic variable stress impairs energy metabolism in prefrontal cortex and hippocampus of rats: prevention by chronic antioxidant treatment. Metab Brain Dis 25(2):169\u201376","journal-title":"Metab Brain Dis"},{"issue":"1","key":"9617_CR79","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpsychires.2011.09.018","volume":"46","author":"WT Regenold","year":"2012","unstructured":"Regenold WT, Pratt M, Nekkalapu S, Shapiro PS, Kristian T, Fiskum G (2012) Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: implications for brain energy metabolism and neurotrophic signaling. J Psychiatr Res 46(1):95\u2013104","journal-title":"J Psychiatr Res"},{"issue":"2","key":"9617_CR80","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12035-013-8497-4","volume":"48","author":"G Oxenkrug","year":"2013","unstructured":"Oxenkrug G (2013) Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways. Mol Neurobiol 48(2):294\u2013301","journal-title":"Mol Neurobiol"},{"issue":"1","key":"9617_CR81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/mp.2014.163","volume":"20","author":"PW Gold","year":"2015","unstructured":"Gold PW (2015) The organization of the stress system and its dysregulation in depressive illness. Mol Psychiatry 20(1):32\u201347","journal-title":"Mol Psychiatry"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9617-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9617-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9617-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9617-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T14:03:37Z","timestamp":1567433017000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-015-9617-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["9617"],"URL":"https:\/\/doi.org\/10.1007\/s12035-015-9617-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}