{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:35:30Z","timestamp":1790418930726,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Biotechnology, Govt. of India","award":["BT\/PR14241\/MED\/30\/423\/2010"],"award-info":[{"award-number":["BT\/PR14241\/MED\/30\/423\/2010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s12035-015-9667-3","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T03:06:53Z","timestamp":1452049613000},"page":"238-254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation and Neurodegeneration via Augmented Tuberous Sclerosis Complex-2 (TSC-2) Activation in Neuronal Cells"],"prefix":"10.1007","volume":"54","author":[{"given":"Premranjan","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiagarajan","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitali Madhusmita","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangnath","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arttatrana","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"key":"9667_CR1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2337\/diaclin.25.1.6","volume":"25","author":"MM Huizinga","year":"2007","unstructured":"Huizinga MM, Peltier A (2007) Painful diabetic neuropathy: a management-centered review. Clinical Diabetes 25:6\u201315","journal-title":"Clinical Diabetes"},{"key":"9667_CR2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11892-002-0119-x","volume":"2","author":"BA Perkins","year":"2002","unstructured":"Perkins BA, Bril V (2002) Diagnosis and management of diabetic neuropathy. Curr Diab Rep 2:495\u2013500","journal-title":"Curr Diab Rep"},{"key":"9667_CR3","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2337\/dc13-2610","volume":"37","author":"D Selvarajah","year":"2014","unstructured":"Selvarajah D, Wilkinson ID, Maxwell M, Davies J, Sankar A, Boland E, Gandhi R, Tracey I, Tesfaye S (2014) Magnetic resonance neuroimaging study of brain structural differences in diabetic peripheral neuropathy. Diabetes Care 37:1681\u20138","journal-title":"Diabetes Care"},{"key":"9667_CR4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","volume":"119","author":"MV Sofroniew","year":"2010","unstructured":"Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119:7\u201335","journal-title":"Acta Neuropathol"},{"key":"9667_CR5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.neuint.2013.09.010","volume":"63","author":"DP Wong","year":"2013","unstructured":"Wong DP, Chu JM, Hung VK, Lee DK, Cheng CH, Yung KK, Yue KK (2013) Modulation of endoplasmic reticulum chaperone GRP78 by high glucose in hippocampus of streptozotocin-induced diabetic mice and C6 astrocytic cells. Neurochem Int 63:551\u201360","journal-title":"Neurochem Int"},{"key":"9667_CR6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuroscience.2011.11.062","volume":"202","author":"J Wang","year":"2012","unstructured":"Wang J, Li G, Wang Z, Zhang X, Yao L, Wang F, Liu S, Yin J, Ling EA, Wang L, Hao A (2012) High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes. Neuroscience 202:58\u201368","journal-title":"Neuroscience"},{"key":"9667_CR7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biocel.2014.05.038","volume":"53","author":"P Kumar","year":"2014","unstructured":"Kumar P, Rao GN, Pal BB, Pal A (2014) Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase\/Akt and ERK1\/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells. Int J Biochem Cell Biol 53:302\u201319","journal-title":"Int J Biochem Cell Biol"},{"key":"9667_CR8","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","volume":"97","author":"B Halliwell","year":"2006","unstructured":"Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634\u201358","journal-title":"J Neurochem"},{"key":"9667_CR9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.molmed.2008.09.003","volume":"14","author":"S Chrissobolis","year":"2008","unstructured":"Chrissobolis S, Faraci FM (2008) The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med 14:495\u2013502","journal-title":"Trends Mol Med"},{"key":"9667_CR10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2337\/diabetes.53.3.795","volume":"53","author":"N Shanmugam","year":"2004","unstructured":"Shanmugam N, Gaw Gonzalo IT, Natarajan R (2004) Molecular mechanisms of high glucose-induced cyclooxygenase-2 expression in monocytes. Diabetes 53:795\u2013802","journal-title":"Diabetes"},{"key":"9667_CR11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2337\/db09-0284","volume":"59","author":"D Wei","year":"2010","unstructured":"Wei D, Li J, Shen M, Jia W, Chen N, Chen T, Su D, Tian H, Zheng S, Dai Y, Zhao A (2010) Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes 59:471\u20138","journal-title":"Diabetes"},{"key":"9667_CR12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4161\/oxim.3.6.14415","volume":"3","author":"I Afanas\u2019ev","year":"2010","unstructured":"Afanas\u2019ev I (2010) Signaling of reactive oxygen and nitrogen species in diabetes mellitus. Oxid Med Cell Longev 3:361\u201373","journal-title":"Oxid Med Cell Longev"},{"key":"9667_CR13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/ars.2006.1458","volume":"9","author":"T Nishikawa","year":"2007","unstructured":"Nishikawa T, Araki E (2007) Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications. Antioxid Redox Signal 9:343\u201353","journal-title":"Antioxid Redox Signal"},{"key":"9667_CR14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/ajprenal.00370.2007","volume":"294","author":"SL Habib","year":"2008","unstructured":"Habib SL, Riley DJ, Mahimainathan L, Bhandari B, Choudhury GG, Abboud HE (2008) Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol 294:281\u201390","journal-title":"Am J Physiol Renal Physiol"},{"key":"9667_CR15","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.2337\/db07-1579","volume":"57","author":"S Simone","year":"2008","unstructured":"Simone S, Gorin Y, Velagapudi C, Abboud HE, Habib SL (2008) Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine-DNA glycosylase. Diabetes 57:2626\u201336","journal-title":"Diabetes"},{"key":"9667_CR16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","volume":"13","author":"AR Tee","year":"2003","unstructured":"Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J (2003) Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13:1259\u201368","journal-title":"Curr Biol"},{"key":"9667_CR17","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","volume":"5","author":"Y Zhang","year":"2003","unstructured":"Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5:578\u201381","journal-title":"Nat Cell Biol"},{"key":"9667_CR18","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1038\/sj.onc.1209660","volume":"25","author":"A Freilinger","year":"2006","unstructured":"Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer SJ, Hengstschl\u00e4ger M (2006) Tuberin activates the proapoptotic molecule BAD. Oncogene 25:6467\u201379","journal-title":"Oncogene"},{"key":"9667_CR19","doi-asserted-by":"crossref","first-page":"40450","DOI":"10.1074\/jbc.M507553200","volume":"280","author":"PO Hassa","year":"2005","unstructured":"Hassa PO, Haenni SS, Buerki C, Meier NI, Lane WS, Owen H, Gersbach M, Imhof R, Hottiger MO (2005) Acetylation of poly(ADP-ribose) polymerase-1 by p300\/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem 280:40450\u201364","journal-title":"J Biol Chem"},{"key":"9667_CR20","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.2337\/db12-1374","volume":"62","author":"M Kassan","year":"2013","unstructured":"Kassan M, Choi SK, Gal\u00e1n M, Bishop A, Umezawa K, Trebak M, Belmadani S, Matrougui K (2013) Enhanced NF-\u03baB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes 62:2078\u201387","journal-title":"Diabetes"},{"key":"9667_CR21","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1158\/0008-5472.CAN-13-0588","volume":"74","author":"E Lopez-Rivera","year":"2014","unstructured":"Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso J, Sikora AG (2014) Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res 74:1067\u201378","journal-title":"Cancer Res"},{"key":"9667_CR22","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","volume":"2","author":"VW Yong","year":"2001","unstructured":"Yong VW, Power C, Forsyth P, Edwards DR (2001) Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2:502\u201311","journal-title":"Nat Rev Neurosci"},{"key":"9667_CR23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.2002.tb04439.x","volume":"971","author":"LA Sombers","year":"2002","unstructured":"Sombers LA, Colliver TL, Ewing AG (2002) Differentiated PC12 cells: a better model system for the study of the VMAT\u2019s effects on neuronal communication. Ann N Y Acad Sci 971:86\u20138","journal-title":"Ann N Y Acad Sci"},{"key":"9667_CR24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1254\/jphs.FP0071092","volume":"106","author":"L Tie","year":"2008","unstructured":"Tie L, Xu Y, Lin YH, Yao XH, Wu HL, Li YH, Shen ZF, Yu HM, Li XJ (2008) Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors. J Pharmacol Sci 106:28\u201337","journal-title":"J Pharmacol Sci"},{"key":"9667_CR25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neulet.2009.03.100","volume":"459","author":"AM Sharifi","year":"2009","unstructured":"Sharifi AM, Eslami H, Larijani B, Davoodi J (2009) Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett 459:47\u201351","journal-title":"Neurosci Lett"},{"key":"9667_CR26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2013.12.019","volume":"560","author":"WC Zhao","year":"2014","unstructured":"Zhao WC, Zhang B, Liao MJ, Zhang WX, He WY, Wang HB, Yang CX (2014) Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord. Neurosci Lett 560:81\u20135","journal-title":"Neurosci Lett"},{"key":"9667_CR27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1463-1326.2008.00987.x","volume":"11","author":"CL Allen","year":"2009","unstructured":"Allen CL, Bayraktutan U (2009) Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood\u2013brain barrier hyperpermeability. Diabetes Obes Metab 11:480\u201390","journal-title":"Diabetes Obes Metab"},{"key":"9667_CR28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/CS20040281","volume":"108","author":"MF Cury-Boaventura","year":"2005","unstructured":"Cury-Boaventura MF, Curi R (2005) Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. Clin Sci (Lond) 108:245\u201353","journal-title":"Clin Sci (Lond)"},{"key":"9667_CR29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.freeradbiomed.2009.11.011","volume":"48","author":"R Manikandan","year":"2010","unstructured":"Manikandan R, Thiagarajan R, Beulaja S, Sudhandiran G, Arumugam M (2010) Curcumin prevents free radical-mediated cataractogenesis through modulations in lens calcium. Free Radic Biol Med 48:483\u201392","journal-title":"Free Radic Biol Med"},{"key":"9667_CR30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neulet.2004.11.077","volume":"376","author":"BK Yoo","year":"2005","unstructured":"Yoo BK, Choi JW, Han BH, Kim WK, Kim HC, Ko KH (2005) Role of MAPK\/ERK1\/2 in the glucose deprivation-induced death in immunostimulated astroglia. Neurosci Lett 376:171\u20136","journal-title":"Neurosci Lett"},{"key":"9667_CR31","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.freeradbiomed.2009.09.011","volume":"47","author":"A Pal","year":"2009","unstructured":"Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R (2009) Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med 47:1640\u201351","journal-title":"Free Radic Biol Med"},{"key":"9667_CR32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jcp.20706","volume":"209","author":"YH Kim","year":"2006","unstructured":"Kim YH, Heo JS, Han HJ (2006) High glucose increase cell cycle regulatory proteins level of mouse embryonic stem cells via PI3-K\/Akt and MAPKs signal pathways. J Cell Physiol 209:94\u2013102","journal-title":"J Cell Physiol"},{"key":"9667_CR33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0923-1811(03)00006-9","volume":"31","author":"K Nakai","year":"2003","unstructured":"Nakai K, Fujii S, Yamamoto A, Igarashi J, Kubota Y, Kosaka H (2003) Effects of high glucose on NO synthesis in human keratinocyte cell line (HaCaT). J Dermatol Sci 31:211\u20138","journal-title":"J Dermatol Sci"},{"key":"9667_CR34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mrfmmm.2003.07.004","volume":"531","author":"P Fortini","year":"2003","unstructured":"Fortini P, Pascucci B, Parlanti E, D\u2019Errico M, Simonelli V, Dogliotti E (2003) 8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways. Mutat Res 531:127\u201339","journal-title":"Mutat Res"},{"key":"9667_CR35","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1073\/pnas.94.15.8010","volume":"94","author":"JP Radicella","year":"1997","unstructured":"Radicella JP, Dherin C, Desmaze C, Fox MS, Boiteux S (1997) Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94:8010\u20135","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9667_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","volume":"192","author":"JL Martindale","year":"2002","unstructured":"Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signalling for suicide and survival. J Cell Physiol 192:1\u201315","journal-title":"J Cell Physiol"},{"key":"9667_CR37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2007.9.233","volume":"9","author":"KT Kishida","year":"2007","unstructured":"Kishida KT, Klann E (2007) Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal 9:233\u201344","journal-title":"Antioxid Redox Signal"},{"key":"9667_CR38","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/aps.2010.174","volume":"32","author":"Y Quan","year":"2011","unstructured":"Quan Y, Jiang CT, Xue B, Zhu SG, Wang X (2011) High glucose stimulates TNF\u03b1 and MCP-1 expression in rat microglia via ROS and NF-\u03baB pathways. Acta Pharmacol Sin 32:188\u201393","journal-title":"Acta Pharmacol Sin"},{"key":"9667_CR39","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1136\/bjophthalmol-2013-304438","volume":"98","author":"A Samanta","year":"2014","unstructured":"Samanta A, Kumar P, Machhua S, Rao GN, Pal A (2014) Incidence of cystoid macular oedema in diabetic patients after phacoemulsification and free radical link to its pathogenesis. Br J Ophthalmol 98:1266\u201372","journal-title":"Br J Ophthalmol"},{"key":"9667_CR40","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2174\/092986706776872952","volume":"13","author":"E Tiligada","year":"2006","unstructured":"Tiligada E (2006) Nuclear translocation during the cross-talk between cellular stress, cell cycle and anticancer agents. Curr Med Chem 13:1317\u201320","journal-title":"Curr Med Chem"},{"key":"9667_CR41","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s10875-010-9507-1","volume":"31","author":"S Agrawal","year":"2011","unstructured":"Agrawal S, Gollapudi S, Su H, Gupta S (2011) Leptin activates human B cells to secrete TNF-\u03b1, IL-6, and IL-10 via JAK2\/STAT3 and p38MAPK\/ERK1\/2 signaling pathway. J Clin Immunol 31:472\u20138","journal-title":"J Clin Immunol"},{"key":"9667_CR42","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417\u201326","journal-title":"Mol Cell"},{"key":"9667_CR43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1568-7864(02)00214-8","volume":"2","author":"K Tsuruya","year":"2003","unstructured":"Tsuruya K, Furuichi M, Tominaga Y, Shinozaki M, Tokumoto M, Yoshimitsu T, Fukuda K, Kanai H, Hirakata H, Iida M, Nakabeppu Y (2003) Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. DNA Repair (Amst) 2:211\u201329","journal-title":"DNA Repair (Amst)"},{"key":"9667_CR44","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/cvr\/cvq005","volume":"86","author":"S Walsh","year":"2010","unstructured":"Walsh S, Pont\u00e9n A, Fleischmann BK, Jovinge S (2010) Cardiomyocyte cell cycle control and growth estimation in vivo\u2014an analysis based on cardiomyocyte nuclei. Cardiovasc Res 86:365\u201373","journal-title":"Cardiovasc Res"},{"key":"9667_CR45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrn1434","volume":"10","author":"JK Andersen","year":"2004","unstructured":"Andersen JK (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10:18\u201325","journal-title":"Nat Med"},{"key":"9667_CR46","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2337\/diab.46.2.S38","volume":"46","author":"PA Low","year":"1997","unstructured":"Low PA, Nickander KK, Tritschler HJ (1997) The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 46:38\u201342","journal-title":"Diabetes"},{"key":"9667_CR47","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1464-5491.1995.tb00544.x","volume":"12","author":"MJ Stevens","year":"1995","unstructured":"Stevens MJ, Feldman EL, Greene DA (1995) The aetiology of diabetic neuropathy: the combined roles of metabolic and vascular defects. Diabet Med 12:566\u201379","journal-title":"Diabet Med"},{"key":"9667_CR48","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1681\/ASN.2013080901","volume":"25","author":"MA Lanaspa","year":"2014","unstructured":"Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ (2014) Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol 25:2526\u201338","journal-title":"J Am Soc Nephrol"},{"key":"9667_CR49","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2337\/diabetes.47.6.859","volume":"47","author":"D Koya","year":"1998","unstructured":"Koya D, King GL (1998) Protein kinase C activation and the development of diabetic complications. Diabetes 47:859\u201366","journal-title":"Diabetes"},{"key":"9667_CR50","doi-asserted-by":"crossref","first-page":"12558","DOI":"10.1074\/jbc.273.20.12558","volume":"273","author":"NE Ward","year":"1998","unstructured":"Ward NE, Pierce DS, Chung SE, Gravitt KR, O\u2019Brian CA (1998) Irreversible inactivation of protein kinase C by glutathione. J Biol Chem 273:12558\u201366","journal-title":"J Biol Chem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9667-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-015-9667-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9667-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-015-9667-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:48:09Z","timestamp":1559429289000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-015-9667-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,6]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["9667"],"URL":"https:\/\/doi.org\/10.1007\/s12035-015-9667-3","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,6]]}}}