{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T21:18:08Z","timestamp":1774300688900,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471163"],"award-info":[{"award-number":["81471163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300489"],"award-info":[{"award-number":["81300489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National \u201c973\u201d project","award":["2013CB945404"],"award-info":[{"award-number":["2013CB945404"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s12035-016-0164-0","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T08:04:54Z","timestamp":1475741094000},"page":"6304-6316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["MARK2\/Par1b Insufficiency Attenuates DVL Gene Transcription via Histone Deacetylation in Lumbosacral Spina Bifida"],"prefix":"10.1007","volume":"54","author":[{"given":"Shuyuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoling","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengrong","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"issue":"21","key":"164_CR1","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1242\/dev.128.21.4189","volume":"128","author":"C Kiecker","year":"2001","unstructured":"Kiecker C, Niehrs C (2001) A morphogen gradient of Wnt\/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 128(21):4189\u20134201","journal-title":"Development"},{"issue":"5","key":"164_CR2","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.devcel.2005.09.011","volume":"9","author":"C Kimura-Yoshida","year":"2005","unstructured":"Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I (2005) Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell 9(5):639\u2013650. doi: 10.1016\/j.devcel.2005.09.011","journal-title":"Dev Cell"},{"issue":"5580","key":"164_CR3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1126\/science.1074192","volume":"297","author":"A Chenn","year":"2002","unstructured":"Chenn A, Walsh CA (2002) Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297(5580):365\u2013369. doi: 10.1126\/science.1074192","journal-title":"Science"},{"issue":"12","key":"164_CR4","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1242\/dev.01165","volume":"131","author":"Y Hirabayashi","year":"2004","unstructured":"Hirabayashi Y, Itoh Y, Tabata H, Nakajima K, Akiyama T, Masuyama N, Gotoh Y (2004) The Wnt\/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131(12):2791\u20132801. doi: 10.1242\/dev.01165","journal-title":"Development"},{"issue":"1","key":"164_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.devcel.2011.06.011","volume":"21","author":"RS Gray","year":"2011","unstructured":"Gray RS, Roszko I, Solnica-Krezel L (2011) Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell 21(1):120\u2013133. doi: 10.1016\/j.devcel.2011.06.011","journal-title":"Dev Cell"},{"issue":"20","key":"164_CR6","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1242\/dev.02068","volume":"132","author":"JB Wallingford","year":"2005","unstructured":"Wallingford JB, Habas R (2005) The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132(20):4421\u20134436. doi: 10.1242\/dev.02068","journal-title":"Development"},{"key":"164_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0070-2153(05)72002-0","volume":"72","author":"CC Malbon","year":"2006","unstructured":"Malbon CC, Wang HY (2006) Dishevelled: a mobile scaffold catalyzing development. Curr Top Dev Biol 72:153\u2013166. doi: 10.1016\/S0070-2153(05)72002-0","journal-title":"Curr Top Dev Biol"},{"issue":"1\u20132","key":"164_CR8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4773(96)00549-7","volume":"58","author":"J Klingensmith","year":"1996","unstructured":"Klingensmith J, Yang Y, Axelrod JD, Beier DR, Perrimon N, Sussman DJ (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev 58(1\u20132):15\u201326","journal-title":"Mech Dev"},{"issue":"2","key":"164_CR9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1101\/gr.5.2.116","volume":"5","author":"N Lijam","year":"1995","unstructured":"Lijam N, Sussman DJ (1995) Organization and promoter analysis of the mouse dishevelled-1 gene. Genome Res 5(2):116\u2013124","journal-title":"Genome Res"},{"issue":"2","key":"164_CR10","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1006\/geno.1997.4713","volume":"42","author":"MV Semenov","year":"1997","unstructured":"Semenov MV, Snyder M (1997) Human dishevelled genes constitute a DHR-containing multigene family. Genomics 42(2):302\u2013310. doi: 10.1006\/geno.1997.4713","journal-title":"Genomics"},{"issue":"3","key":"164_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/(SICI)1097-0177(199611)207:3<253::AID-AJA2>3.0.CO;2-G","volume":"207","author":"M Tsang","year":"1996","unstructured":"Tsang M, Lijam N, Yang Y, Beier DR, Wynshaw-Boris A, Sussman DJ (1996) Isolation and characterization of mouse dishevelled-3. Dev Dyn 207(3):253\u2013262. doi: 10.1002\/(SICI)1097-0177(199611)207:3<253::AID-AJA2>3.0.CO;2-G","journal-title":"Dev Dyn"},{"issue":"22","key":"164_CR12","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1101\/gad.1957710","volume":"24","author":"L Grumolato","year":"2010","unstructured":"Grumolato L, Liu G, Mong P, Mudbhary R, Biswas R, Arroyave R, Vijayakumar S, Economides AN, Aaronson SA (2010) Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev 24(22):2517\u20132530. doi: 10.1101\/gad.1957710","journal-title":"Genes Dev"},{"issue":"2","key":"164_CR13","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1242\/dev.013540","volume":"135","author":"X Zeng","year":"2008","unstructured":"Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X (2008) Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation\/activation via frizzled, dishevelled and axin functions. Development 135(2):367\u2013375. doi: 10.1242\/dev.013540","journal-title":"Development"},{"issue":"50","key":"164_CR14","doi-asserted-by":"publisher","first-page":"52703","DOI":"10.1074\/jbc.M408675200","volume":"279","author":"E Torban","year":"2004","unstructured":"Torban E, Wang HJ, Groulx N, Gros P (2004) Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem 279(50):52703\u201352713. doi: 10.1074\/jbc.M408675200","journal-title":"J Biol Chem"},{"issue":"6","key":"164_CR15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1590\/S0102-86502007000600007","volume":"22","author":"PR Quemelo","year":"2007","unstructured":"Quemelo PR, Lourenco CM, Peres LC (2007) Teratogenic effect of retinoic acid in Swiss mice. Acta Cir Bras 22(6):451\u2013456","journal-title":"Acta Cir Bras"},{"issue":"9","key":"164_CR16","doi-asserted-by":"publisher","first-page":"4352","DOI":"10.3390\/ijerph10094352","volume":"10","author":"A Imbard","year":"2013","unstructured":"Imbard A, Benoist JF, Blom HJ (2013) Neural tube defects, folic acid and methylation. Int J Environ Res Public Health 10(9):4352\u20134389. doi: 10.3390\/ijerph10094352","journal-title":"Int J Environ Res Public Health"},{"key":"164_CR17","doi-asserted-by":"publisher","unstructured":"Wallingford JB, Niswander LA, Shaw GM, Finnell RH (2013) The continuing challenge of understanding, preventing, and treating neural tube defects. Science 339. doi: 10.1126\/science.1222002","DOI":"10.1126\/science.1222002"},{"issue":"8","key":"164_CR18","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S1474-4422(13)70110-8","volume":"12","author":"AJ Copp","year":"2013","unstructured":"Copp AJ, Stanier P, Greene ND (2013) Neural tube defects: recent advances, unsolved questions, and controversies. Lancet Neurol 12(8):799\u2013810. doi: 10.1016\/S1474-4422(13)70110-8","journal-title":"Lancet Neurol"},{"issue":"36","key":"164_CR19","doi-asserted-by":"publisher","first-page":"12843","DOI":"10.1073\/pnas.0501963102","volume":"102","author":"M Carter","year":"2005","unstructured":"Carter M, Chen X, Slowinska B, Minnerath S, Glickstein S, Shi L, Campagne F, Weinstein H, Ross ME (2005) Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci U S A 102(36):12843\u201312848. doi: 10.1073\/pnas.0501963102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6803","key":"164_CR20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/35035124","volume":"407","author":"KI Pinson","year":"2000","unstructured":"Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407(6803):535\u2013538. doi: 10.1038\/35035124","journal-title":"Nature"},{"issue":"12","key":"164_CR21","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1242\/dev.076067","volume":"139","author":"CI Wu","year":"2012","unstructured":"Wu CI, Hoffman JA, Shy BR, Ford EM, Fuchs E, Nguyen H, Merrill BJ (2012) Function of Wnt\/beta-catenin in counteracting Tcf3 repression through the Tcf3-beta-catenin interaction. Development 139(12):2118\u20132129. doi: 10.1242\/dev.076067","journal-title":"Development"},{"issue":"1","key":"164_CR22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1242\/dev.101550","volume":"141","author":"T Zhao","year":"2014","unstructured":"Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ (2014) Beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development 141(1):148\u2013157. doi: 10.1242\/dev.101550","journal-title":"Development"},{"issue":"24","key":"164_CR23","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1242\/dev.00164","volume":"129","author":"NS Hamblet","year":"2002","unstructured":"Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A (2002) Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129(24):5827\u20135838","journal-title":"Development"},{"issue":"11","key":"164_CR24","doi-asserted-by":"publisher","first-page":"e1000259","DOI":"10.1371\/journal.pgen.1000259","volume":"4","author":"SL Etheridge","year":"2008","unstructured":"Etheridge SL, Ray S, Li S, Hamblet NS, Lijam N, Tsang M, Greer J, Kardos N, Wang J, Sussman DJ, Chen P, Wynshaw-Boris A (2008) Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4(11):e1000259. doi: 10.1371\/journal.pgen.1000259","journal-title":"PLoS Genet"},{"issue":"23","key":"164_CR25","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1056\/NEJMc0910820","volume":"362","author":"YP Lei","year":"2010","unstructured":"Lei YP, Zhang T, Li H, BL W, Jin L, Wang HY (2010) VANGL2 mutations in human cranial neural-tube defects. N Engl J Med 362(23):2232\u20132235. doi: 10.1056\/NEJMc0910820","journal-title":"N Engl J Med"},{"issue":"14","key":"164_CR26","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1056\/NEJMoa060651","volume":"356","author":"Z Kibar","year":"2007","unstructured":"Kibar Z, Torban E, McDearmid JR, Reynolds A, Berghout J, Mathieu M, Kirillova I, De Marco P, Merello E, Hayes JM, Wallingford JB, Drapeau P, Capra V, Gros P (2007) Mutations in VANGL1 associated with neural-tube defects. N Engl J Med 356(14):1432\u20131437. doi: 10.1056\/NEJMoa060651","journal-title":"N Engl J Med"},{"issue":"1","key":"164_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/bdra.23305","volume":"103","author":"E Merello","year":"2015","unstructured":"Merello E, Mascelli S, Raso A, Piatelli G, Consales A, Cama A, Kibar Z, Capra V, Marco PD (2015) Expanding the mutational spectrum associated to neural tube defects: literature revision and description of novel VANGL1 mutations. Birth Defects Res A Clin Mol Teratol 103(1):51\u201361. doi: 10.1002\/bdra.23305","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"8","key":"164_CR28","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/bdra.23255","volume":"100","author":"P De Marco","year":"2014","unstructured":"De Marco P, Merello E, Piatelli G, Cama A, Kibar Z, Capra V (2014) Planar cell polarity gene mutations contribute to the etiology of human neural tube defects in our population. Birth Defects Res A Clin Mol Teratol 100(8):633\u2013641. doi: 10.1002\/bdra.23255","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"164_CR29","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s12031-012-9871-9","volume":"49","author":"P De Marco","year":"2013","unstructured":"De Marco P, Merello E, Consales A, Piatelli G, Cama A, Kibar Z, Capra V (2013) Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. J Mol Neurosci 49(3):582\u2013588. doi: 10.1007\/s12031-012-9871-9","journal-title":"J Mol Neurosci"},{"issue":"7","key":"164_CR30","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/bdra.23157","volume":"97","author":"E Merello","year":"2013","unstructured":"Merello E, Kibar Z, Allache R, Piatelli G, Cama A, Capra V, De Marco P (2013) Rare missense variants in DVL1, one of the human counterparts of the Drosophila dishevelled gene, do not confer increased risk for neural tube defects. Birth Defects Res A Clin Mol Teratol 97(7):452\u2013455. doi: 10.1002\/bdra.23157","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"4","key":"164_CR31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)80844-2","volume":"101","author":"K Kemphues","year":"2000","unstructured":"Kemphues K (2000) PARsing embryonic polarity. Cell 101(4):345\u2013348","journal-title":"Cell"},{"issue":"Suppl 1","key":"164_CR32","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/S0925-4773(03)00107-2","volume":"119","author":"O Ossipova","year":"2002","unstructured":"Ossipova O, He X, Green J (2002) Molecular cloning and developmental expression of Par-1\/MARK homologues XPar-1A and XPar-1B from Xenopus laevis. Mech Dev 119(Suppl 1):S143\u2013S148","journal-title":"Mech Dev"},{"issue":"21","key":"164_CR33","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1038\/sj.emboj.7600381","volume":"23","author":"M Kusakabe","year":"2004","unstructured":"Kusakabe M, Nishida E (2004) The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC. EMBO J 23(21):4190\u20134201. doi: 10.1038\/sj.emboj.7600381","journal-title":"EMBO J"},{"issue":"7","key":"164_CR34","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/35083016","volume":"3","author":"TQ Sun","year":"2001","unstructured":"Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT (2001) PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol 3(7):628\u2013636. doi: 10.1038\/35083016","journal-title":"Nat Cell Biol"},{"issue":"6","key":"164_CR35","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.devcel.2005.04.011","volume":"8","author":"O Ossipova","year":"2005","unstructured":"Ossipova O, Dhawan S, Sokol S, Green JB (2005) Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell 8(6):829\u2013841. doi: 10.1016\/j.devcel.2005.04.011","journal-title":"Dev Cell"},{"issue":"19","key":"164_CR36","doi-asserted-by":"publisher","first-page":"7086","DOI":"10.1128\/MCB.00231-06","volume":"26","author":"F Dequiedt","year":"2006","unstructured":"Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R (2006) New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol 26(19):7086\u20137102. doi: 10.1128\/MCB.00231-06","journal-title":"Mol Cell Biol"},{"issue":"10","key":"164_CR37","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/bdra.20397","volume":"79","author":"X Gu","year":"2007","unstructured":"Gu X, Lin L, Zheng X, Zhang T, Song X, Wang J, Li X, Li P, Chen G, Wu J, Wu L, Liu J (2007) High prevalence of NTDs in Shanxi Province: a combined epidemiological approach. Birth Defects Res A Clin Mol Teratol 79(10):702\u2013707. doi: 10.1002\/bdra.20397","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"164_CR38","doi-asserted-by":"publisher","first-page":"e54492","DOI":"10.1371\/journal.pone.0054492","volume":"8","author":"X Chen","year":"2013","unstructured":"Chen X, Shen Y, Gao Y, Zhao H, Sheng X, Zou J, Lip V, Xie H, Guo J, Shao H, Bao Y, Shen J, Niu B, Gusella JF, BL W, Zhang T (2013) Detection of copy number variants reveals association of cilia genes with neural tube defects. PLoS One 8(1):e54492. doi: 10.1371\/journal.pone.0054492","journal-title":"PLoS One"},{"issue":"50","key":"164_CR39","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1073\/pnas.1016071107","volume":"107","author":"MP Creyghton","year":"2010","unstructured":"Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R (2010) Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A 107(50):21931\u201321936. doi: 10.1073\/pnas.1016071107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"164_CR40","doi-asserted-by":"publisher","first-page":"e1001354","DOI":"10.1371\/journal.pgen.1001354","volume":"7","author":"B Guillemette","year":"2011","unstructured":"Guillemette B, Drogaris P, Lin HH, Armstrong H, Hiragami-Hamada K, Imhof A, Bonneil E, Thibault P, Verreault A, Festenstein RJ (2011) H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet 7(3):e1001354. doi: 10.1371\/journal.pgen.1001354","journal-title":"PLoS Genet"},{"issue":"5","key":"164_CR41","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1017\/S1368980008002735","volume":"12","author":"T Zhang","year":"2009","unstructured":"Zhang T, Xin R, Gu X, Wang F, Pei L, Lin L, Chen G, Wu J, Zheng X (2009) Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 12(5):680\u2013686. doi: 10.1017\/S1368980008002735","journal-title":"Public Health Nutr"},{"issue":"6","key":"164_CR42","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12263-013-0355-5","volume":"8","author":"F Wang","year":"2013","unstructured":"Wang F, Wang J, Guo J, Chen X, Guan Z, Zhao H, Xie H, Liu C, Bao Y, Zou J, Niu B, Zhang T (2013) PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case-control study in a population with relatively low folate intake. Genes Nutr 8(6):581\u2013587. doi: 10.1007\/s12263-013-0355-5","journal-title":"Genes Nutr"},{"issue":"9","key":"164_CR43","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/dneu.22170","volume":"74","author":"J Wang","year":"2014","unstructured":"Wang J, Wang X, Guan T, Xiang Q, Wang M, Zhang Z, Guan Z, Wang G, Zhu Z, Xie Q, Li G, Guo J, Wang F, Zhang Z, Niu B, Zhang T (2014) Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects. Dev Neurobiol 74(9):877\u2013893. doi: 10.1002\/dneu.22170","journal-title":"Dev Neurobiol"},{"issue":"4","key":"164_CR44","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","volume":"119","author":"RB Vega","year":"2004","unstructured":"Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN (2004) Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119(4):555\u2013566. doi: 10.1016\/j.cell.2004.10.024","journal-title":"Cell"},{"key":"164_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-213X-12-16","volume":"12","author":"A DeLaurier","year":"2012","unstructured":"DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, Postlethwait JH, Kimmel CB (2012) Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol 12:16. doi: 10.1186\/1471-213X-12-16","journal-title":"BMC Dev Biol"},{"issue":"5","key":"164_CR46","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrg3413","volume":"14","author":"JL Ronan","year":"2013","unstructured":"Ronan JL, Wu W, Crabtree GR (2013) From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet 14(5):347\u2013359. doi: 10.1038\/nrg3413","journal-title":"Nat Rev Genet"},{"issue":"4","key":"164_CR47","doi-asserted-by":"publisher","first-page":"e94348","DOI":"10.1371\/journal.pone.0094348","volume":"9","author":"JL Davila","year":"2014","unstructured":"Davila JL, Goff LA, Ricupero CL, Camarillo C, Oni EN, Swerdel MR, Toro-Ramos AJ, Li J, Hart RP (2014) A positive feedback mechanism that regulates expression of miR-9 during neurogenesis. PLoS One 9(4):e94348. doi: 10.1371\/journal.pone.0094348","journal-title":"PLoS One"},{"issue":"2","key":"164_CR48","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/labinvest.2015.145","volume":"96","author":"D Lu","year":"2016","unstructured":"Lu D, Bao D, Dong W, Liu N, Zhang X, Gao S, Ge W, Gao X, Zhang L (2016) Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway. Lab Investig 96(2):239\u2013248. doi: 10.1038\/labinvest.2015.145","journal-title":"Lab Investig"},{"issue":"2","key":"164_CR49","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/path.2643","volume":"220","author":"AJ Copp","year":"2010","unstructured":"Copp AJ, Greene ND (2010) Genetics and development of neural tube defects. J Pathol 220(2):217\u2013230. doi: 10.1002\/path.2643","journal-title":"J Pathol"},{"issue":"1","key":"164_CR50","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.2105\/AJPH.2015.302902","volume":"106","author":"CA Atta","year":"2016","unstructured":"Atta CA, Fiest KM, Frolkis AD, Jette N, Pringsheim T, St Germaine-Smith C, Rajapakse T, Kaplan GG, Metcalfe A (2016) Global birth prevalence of spina bifida by folic acid fortification status: a systematic review and meta-analysis. Am J Public Health 106(1):e24\u2013e34. doi: 10.2105\/AJPH.2015.302902","journal-title":"Am J Public Health"},{"issue":"2","key":"164_CR51","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/scd.2011.0100","volume":"21","author":"S Ichi","year":"2012","unstructured":"Ichi S, Nakazaki H, Boshnjaku V, Singh RM, Mania-Farnell B, Xi G, McLone DG, Tomita T, Mayanil CS (2012) Fetal neural tube stem cells from Pax3 mutant mice proliferate, differentiate, and form synaptic connections when stimulated with folic acid. Stem Cells Dev 21(2):321\u2013330. doi: 10.1089\/scd.2011.0100","journal-title":"Stem Cells Dev"},{"issue":"2","key":"164_CR52","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3164\/jcbn.10-47","volume":"47","author":"H Liu","year":"2010","unstructured":"Liu H, Huang GW, Zhang XM, Ren DL, XW J (2010) Folic acid supplementation stimulates notch signaling and cell proliferation in embryonic neural stem cells. J Clin Biochem Nutr 47(2):174\u2013180. doi: 10.3164\/jcbn.10-47","journal-title":"J Clin Biochem Nutr"},{"issue":"4","key":"164_CR53","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.jnutbio.2013.12.010","volume":"25","author":"M Yu","year":"2014","unstructured":"Yu M, Li W, Luo S, Zhang Y, Liu H, Gao Y, Wang X, Wilson JX, Huang G (2014) Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of PI3K\/Akt\/CREB. J Nutr Biochem 25(4):496\u2013502. doi: 10.1016\/j.jnutbio.2013.12.010","journal-title":"J Nutr Biochem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-0164-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0164-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0164-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T20:52:12Z","timestamp":1657399932000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-0164-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["164"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-0164-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,6]]}}}