{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:29:02Z","timestamp":1790623742448,"version":"4.1.0"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008591","name":"Fondazione Grigioni per il Morbo di Parkinson","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008591","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dote ricerca, FSE, Regione Lombardia"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s12035-016-0188-5","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T06:09:37Z","timestamp":1476770977000},"page":"6762-6774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Microtubule Destabilization Paves the Way to Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"54","author":[{"given":"D.","family":"Cartelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cappelletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"188_CR1","unstructured":"Cajal SR (1906) Nobel lecture: the structure and connexions of neurons. From Nobel Lectures, Physiology or Medicine 1901-1921, Elsevier Publishing Company, Amsterdam,1967"},{"issue":"15","key":"188_CR2","doi-asserted-by":"publisher","first-page":"R677","DOI":"10.1016\/j.cub.2015.06.020","volume":"25","author":"CH Coles","year":"2015","unstructured":"Coles CH, Bradke F (2015) Coordinating neuronal actin-microtubule dynamics. Curr Biol 25(15):R677\u201391. doi: 10.1016\/j.cub.2015.06.020","journal-title":"Curr Biol"},{"issue":"3","key":"188_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.gde.2011.01.003","volume":"21","author":"MA Tischfield","year":"2011","unstructured":"Tischfield MA, Cederquist GY, Gupta ML Jr, Engle EC (2011) Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev 21(3):286\u201394. doi: 10.1016\/j.gde.2011.01.003","journal-title":"Curr Opin Genet Dev"},{"issue":"3","key":"188_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrn3380","volume":"14","author":"S Millecamps","year":"2013","unstructured":"Millecamps S, Julien JP (2013) Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci 14(3):161\u201376. doi: 10.1038\/nrn3380","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"188_CR5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.neuron.2014.09.027","volume":"84","author":"BN Smith","year":"2014","unstructured":"Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp S, Kenna KP, Scotter EL, Kost J et al (2014) Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS. Neuron 84(2):324\u201331. doi: 10.1016\/j.neuron.2014.09.027","journal-title":"Neuron"},{"issue":"10","key":"188_CR6","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/emboj.2013.59","volume":"32","author":"S Niwa","year":"2013","unstructured":"Niwa S, Takahashi H, Hirokawa N (2013) \u03b2-Tubulin mutations that cause severe neuropathies disrupt axonal transport. EMBO J 32(10):1352\u201364. doi: 10.1038\/emboj.2013.59","journal-title":"EMBO J"},{"issue":"Pt 10","key":"188_CR7","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1093\/brain\/awt153","volume":"136","author":"PW Baas","year":"2013","unstructured":"Baas PW, Ahmad FJ (2013) Beyond taxol: microtubule-based treatment of disease and injury of the nervous system. Brain 136(Pt 10):2937\u201351. doi: 10.1093\/brain\/awt153","journal-title":"Brain"},{"issue":"4","key":"188_CR8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1083\/jcb.106.4.1205","volume":"106","author":"M Sato","year":"1988","unstructured":"Sato M, Schwartz WH, Selden SC, Pollard TD (1988) Mechanical properties of brain tubulin and microtubules. J Cell Biol 106(4):1205\u201311","journal-title":"J Cell Biol"},{"issue":"5991","key":"188_CR9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/312237a0","volume":"312","author":"T Mitchison","year":"1984","unstructured":"Mitchison T, Kirschner M (1984) Dynamic instability of microtubule growth. Nature 312(5991):237\u201342","journal-title":"Nature"},{"issue":"3","key":"188_CR10","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuron.2015.05.046","volume":"87","author":"LC Kapitein","year":"2015","unstructured":"Kapitein LC, Hoogenraad CC (2015) Building the neuronal microtubule cytoskeleton. Neuron 87(3):492\u2013506. doi: 10.1016\/j.neuron.2015.05.046","journal-title":"Neuron"},{"issue":"21","key":"188_CR11","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1073\/pnas.85.21.8335","volume":"85","author":"PW Baas","year":"1988","unstructured":"Baas PW, Deitch JS, Black MM, Banker GA (1988) Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc Natl Acad Sci U S A 85(21):8335\u20139","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"188_CR12","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1523\/JNEUROSCI.2430-15.2016","volume":"36","author":"K Wai Yau","year":"2016","unstructured":"Wai Yau K, Schatzle P, Tortosa E, Pages S, Holtmaat A, Kapitein LC, Hoogenraad CC (2016) Dendrites In vitro and in vivo contain microtubules of opposite polarity and axon formation correlates with uniform plus-end-out microtubule orientation. J Neurosci 36(4):1071\u20131085. doi: 10.1523\/JNEUROSCI.2430-15.2016","journal-title":"J Neurosci"},{"issue":"32","key":"188_CR13","doi-asserted-by":"publisher","first-page":"11370","DOI":"10.1073\/pnas.0805199105","volume":"105","author":"AC Kwan","year":"2008","unstructured":"Kwan AC, Dombeck DA, Webb WW (2008) Polarized microtubule arrays in apical dendrites and axons. Proc Natl Acad Sci U S A 105(32):11370\u20135. doi: 10.1073\/pnas.0805199105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"188_CR14","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1038\/ncomms5827","volume":"5","author":"T Kleele","year":"2014","unstructured":"Kleele T, Marinkovi\u0107 P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J et al (2014) An assay to image neuronal microtubule dynamics in mice. Nat Commun 5:4827. doi: 10.1038\/ncomms5827","journal-title":"Nat Commun"},{"issue":"4","key":"188_CR15","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.cub.2009.12.052","volume":"20","author":"LC Kapitein","year":"2009","unstructured":"Kapitein LC, Schlager MA, Kuijpers M, Wulf PS, van Spronsen M, MacKintosh FC, Hoogenraad CC (2009) Mixed microtubules steer dynein-driven cargo transport into dendrites. Curr Biol 20(4):290\u20139. doi: 10.1016\/j.cub.2009.12.052","journal-title":"Curr Biol"},{"issue":"Pt 10","key":"188_CR16","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1093\/brain\/awv234","volume":"38","author":"A McCarthy","year":"2015","unstructured":"McCarthy A, Lonergan R, Olszewska DA, O\u2019Dowd S, Cummins G, Magennis B, Fallon EM, Pender N et al (2015) Closing the tau loop: the missing tau mutation. Brain 38(Pt 10):3100\u20139. doi: 10.1093\/brain\/awv234","journal-title":"Brain"},{"issue":"12","key":"188_CR17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.tins.2014.08.004","volume":"37","author":"H Zempel","year":"2014","unstructured":"Zempel H, Mandelkow E (2014) Lost after translation: missorting of Tau protein and consequences for Alzheimer disease. Trends Neurosci 37(12):721\u201332. doi: 10.1016\/j.tins.2014.08.004","journal-title":"Trends Neurosci"},{"issue":"4","key":"188_CR18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1083\/jcb.200409058","volume":"168","author":"KJ Evans","year":"2005","unstructured":"Evans KJ, Gomes ER, Reisenweber SM, Gundersen GG, Lauring B (2005) Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. J Cell Biol 168(4):599\u2013606","journal-title":"J Cell Biol"},{"issue":"4","key":"188_CR19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1083\/jcb.201406055","volume":"206","author":"C Janke","year":"2014","unstructured":"Janke C (2014) The tubulin code: molecular components, readout mechanisms, and functions. J Cell Biol 206(4):461\u201372. doi: 10.1083\/jcb.201406055","journal-title":"J Cell Biol"},{"issue":"Pt 6","key":"188_CR20","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1242\/jcs.107.6.1529","volume":"107","author":"L Paturle-Lafanech\u00e8re","year":"1994","unstructured":"Paturle-Lafanech\u00e8re L, Manier M, Trigault N, Pirollet F, Mazarguil H, Job D (1994) Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies. J Cell Sci 107(Pt 6):1529\u201343","journal-title":"J Cell Sci"},{"issue":"6","key":"188_CR21","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.cell.2014.03.061","volume":"157","author":"A Szyk","year":"2014","unstructured":"Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N et al (2014) Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell 157(6):1405\u201315. doi: 10.1016\/j.cell.2014.03.061","journal-title":"Cell"},{"issue":"1","key":"188_CR22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.106.1.141","volume":"106","author":"S Khawaja","year":"1988","unstructured":"Khawaja S, Gundersen GG, Bulinski JC (1988) Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level. J Cell Biol 106(1):141\u20139","journal-title":"J Cell Biol"},{"issue":"7","key":"188_CR23","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1083\/jcb.200902142","volume":"185","author":"L Peris","year":"2009","unstructured":"Peris L, Wagenbach M, Lafanech\u00e8re L, Brocard J, Moore AT, Kozielski F, Job D, Wordeman L et al (2009) Motor-dependent microtubule disassembly driven by tubulin tyrosination. J Cell Biol 185(7):1159\u201366. doi: 10.1083\/jcb.200902142","journal-title":"J Cell Biol"},{"issue":"Pt 11","key":"188_CR24","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1242\/jcs.101139","volume":"125","author":"DJ Sharp","year":"2012","unstructured":"Sharp DJ, Ross JL (2012) Microtubule-severing enzymes at the cutting edge. J Cell Sci 125(Pt 11):2561\u20139. doi: 10.1242\/jcs.101139","journal-title":"J Cell Sci"},{"issue":"21","key":"188_CR25","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.cub.2006.09.014","volume":"16","author":"NA Reed","year":"2006","unstructured":"Reed NA, Cai D, Blasius TL, Jih GT, Meyhofer E, Gaertig J, Verhey KJ (2006) Microtubule acetylation promotes kinesin-1 binding and transport. Curr Biol 16(21):2166\u201372","journal-title":"Curr Biol"},{"issue":"Pt 7","key":"188_CR26","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1242\/jcs.026492","volume":"121","author":"S Dunn","year":"2008","unstructured":"Dunn S, Morrison EE, Liverpool TB, Molina-Par\u00eds C, Cross RA, Alonso MC, Peckham M (2008) Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells. J Cell Sci 121(Pt 7):1085\u201395. doi: 10.1242\/jcs.026492","journal-title":"J Cell Sci"},{"issue":"4","key":"188_CR27","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cell.2010.10.014","volume":"143","author":"K Rogowski","year":"2010","unstructured":"Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND et al (2010) A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell 143(4):564\u201378. doi: 10.1016\/j.cell.2010.10.014","journal-title":"Cell"},{"issue":"3","key":"188_CR28","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1083\/jcb.201211017","volume":"200","author":"AE Prota","year":"2013","unstructured":"Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC et al (2013) Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol 200(3):259\u201370. doi: 10.1083\/jcb.201211017","journal-title":"J Cell Biol"},{"issue":"23","key":"188_CR29","doi-asserted-by":"publisher","first-page":"14765","DOI":"10.1074\/jbc.M114.622753","volume":"290","author":"W Song","year":"2015","unstructured":"Song W, Cho Y, Watt D, Cavalli V (2015) Tubulin-tyrosine ligase (TTL)-mediated increase in tyrosinated \u03b1-tubulin in injured axons is required for retrograde injury signaling and axon regeneration. J Biol Chem 290(23):14765\u201375. doi: 10.1074\/jbc.M114.622753","journal-title":"J Biol Chem"},{"issue":"4","key":"188_CR30","doi-asserted-by":"publisher","first-page":"e5405","DOI":"10.1371\/journal.pone.0005405","volume":"4","author":"S Marcos","year":"2009","unstructured":"Marcos S, Moreau J, Backer S, Job D, Andrieux A, Bloch-Gallego E (2009) Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone. PLoS One 4(4):e5405. doi: 10.1371\/journal.pone.0005405","journal-title":"PLoS One"},{"issue":"5840","key":"188_CR31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/294477a0","volume":"294","author":"I Gozes","year":"1981","unstructured":"Gozes I, Sweadner KJ (1981) Multiple tubulin forms are expressed by a single neurone. Nature 294(5840):477\u201380","journal-title":"Nature"},{"issue":"5686","key":"188_CR32","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/276411a0","volume":"276","author":"I Gozes","year":"1978","unstructured":"Gozes I, Littauer UZ (1978) Tubulin microheterogeneity increases with rat brain maturation. Nature 276(5686):411\u20133","journal-title":"Nature"},{"issue":"12","key":"188_CR33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0962-8924(97)01168-9","volume":"7","author":"SA Lewis","year":"1997","unstructured":"Lewis SA, Tian G, Cowan NJ (1997) The alpha- and beta-tubulin folding pathways. Trends Cell Biol 7(12):479\u201384","journal-title":"Trends Cell Biol"},{"key":"188_CR34","doi-asserted-by":"publisher","unstructured":"Vemu A, Atherton J, Spector JO, Szyk A, Moores CA, Roll-Mecak A (2016) Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin. J Biol Chem. doi: 10.1074\/jbc.C116.731133","DOI":"10.1074\/jbc.C116.731133"},{"issue":"4","key":"188_CR35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/ncb2920","volume":"16","author":"M Sirajuddin","year":"2014","unstructured":"Sirajuddin M, Rice LM, Vale RD (2014) Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat Cell Biol 16(4):335\u201344. doi: 10.1038\/ncb2920","journal-title":"Nat Cell Biol"},{"issue":"11","key":"188_CR36","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/nmat4396","volume":"14","author":"L Schaedel","year":"2015","unstructured":"Schaedel L, John K, Gaillard J, Nachury MV, Blanchoin L, Th\u00e9ry M (2015) Microtubules self-repair in response to mechanical stress. Nat Mater 14(11):1156\u201363. doi: 10.1038\/nmat4396","journal-title":"Nat Mater"},{"issue":"5","key":"188_CR37","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.cell.2011.10.037","volume":"147","author":"MK Gardner","year":"2011","unstructured":"Gardner MK, Zanic M, Gell C, Bormuth V, Howard J (2011) Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe. Cell 147(5):1092\u2013103. doi: 10.1016\/j.cell.2011.10.037","journal-title":"Cell"},{"issue":"5","key":"188_CR38","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/bies.201200131","volume":"35","author":"H Bowne-Anderson","year":"2013","unstructured":"Bowne-Anderson H, Zanic M, Kauer M, Howard J (2013) Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe. Bioessays 35(5):452\u201361. doi: 10.1002\/bies.201200131","journal-title":"Bioessays"},{"issue":"14","key":"188_CR39","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.cub.2013.05.059","volume":"23","author":"CE Coombes","year":"2013","unstructured":"Coombes CE, Yamamoto A, Kenzie MR, Odde DJ, Gardner MK (2013) Evolving tip structures can explain age-dependent microtubule catastrophe. Curr Biol 23(14):1342\u20138. doi: 10.1016\/j.cub.2013.05.059","journal-title":"Curr Biol"},{"issue":"6","key":"188_CR40","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nm.2165","volume":"16","author":"JA Obeso","year":"2010","unstructured":"Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M et al (2010) Missing pieces in the Parkinson\u2019s disease puzzle. Nat Med 16(6):653\u201361. doi: 10.1038\/nm.2165","journal-title":"Nat Med"},{"issue":"11","key":"188_CR41","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","volume":"11","author":"L Klingelhoefer","year":"2015","unstructured":"Klingelhoefer L, Reichmann H (2015) Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors. Nat Rev Neurol 11(11):625\u201336. doi: 10.1038\/nrneurol.2015.197","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"188_CR42","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","volume":"39","author":"W Dauer","year":"2003","unstructured":"Dauer W, Przedborski S (2003) Parkinson\u2019s disease: mechanisms and models. Neuron 39(6):889\u2013909","journal-title":"Neuron"},{"key":"188_CR43","doi-asserted-by":"publisher","unstructured":"Pissadaki EK, Bolam JP (2013) The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson\u2019s disease. Front Comput Neurosci 13. doi: 10.3389\/fncom.2013.00013","DOI":"10.3389\/fncom.2013.00013"},{"issue":"3","key":"188_CR44","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.tins.2014.12.009","volume":"38","author":"BH Hunn","year":"2015","unstructured":"Hunn BH, Cragg SJ, Bolam JP, Spillantini MG, Wade-Martins R (2015) Impaired intracellular trafficking defines early Parkinson\u2019s disease. Trends Neurosci 38(3):178\u201388. doi: 10.1016\/j.tins.2014.12.009","journal-title":"Trends Neurosci"},{"issue":"11","key":"188_CR45","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrn1788","volume":"6","author":"M Coleman","year":"2005","unstructured":"Coleman M (2005) Axon degeneration mechanisms: commonality amid diversity. Nat Rev Neurosci 6(11):889\u201398","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"188_CR46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0896-6273(03)00429-X","volume":"39","author":"Q Zhai","year":"2003","unstructured":"Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L et al (2003) Involvement of the ubiquitin-proteasome system in the early stages of Wallerian degeneration. Neuron 39(2):217\u201325","journal-title":"Neuron"},{"issue":"34","key":"188_CR47","doi-asserted-by":"publisher","first-page":"9169","DOI":"10.1523\/JNEUROSCI.0612-07.2007","volume":"27","author":"A Ert\u00fcrk","year":"2007","unstructured":"Ert\u00fcrk A, Hellal F, Enes J, Bradke F (2007) Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci 27(34):9169\u201380. doi: 10.1523\/JNEUROSCI.0612-07.2007","journal-title":"J Neurosci"},{"issue":"6","key":"188_CR48","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1177\/1073858406293853","volume":"12","author":"J Feng","year":"2006","unstructured":"Feng J (2006) Microtubule: a common target for parkin and Parkinson\u2019s disease toxins. Neuroscientist 12(6):469\u201376. doi: 10.1177\/1073858406293853","journal-title":"Neuroscientist"},{"issue":"2","key":"188_CR49","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1042\/BST20150007","volume":"43","author":"G Cappelletti","year":"2015","unstructured":"Cappelletti G, Casagrande F, Calogero A, De Gregorio C, Pezzoli G, Cartelli D (2015) Linking microtubules to Parkinson\u2019s disease: the case of parkin. Biochem Soc Trans 43(2):292\u20136. doi: 10.1042\/BST20150007","journal-title":"Biochem Soc Trans"},{"key":"188_CR50","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0014-4827(61)90033-7","volume":"23","author":"PE Lindahl","year":"1961","unstructured":"Lindahl PE, Oberg KE (1961) The effect of rotenone on respiration and its point of attack. Exp Cell Res 23:228\u201337","journal-title":"Exp Cell Res"},{"issue":"26","key":"188_CR51","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0024-3205(85)90146-8","volume":"36","author":"WJ Nicklas","year":"1985","unstructured":"Nicklas WJ, Vyas I, Heikkila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 36(26):2503\u20138","journal-title":"Life Sci"},{"issue":"5321","key":"188_CR52","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"MH Polymeropoulos","year":"1997","unstructured":"Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H et al (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease. Science 276(5321):2045\u20137","journal-title":"Science"},{"issue":"4","key":"188_CR53","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0304-4165(78)90315-X","volume":"543","author":"LE Marshall","year":"1978","unstructured":"Marshall LE, Himes RH (1978) Rotenone inhibition of tubulin self-assembly. Biochim Biophys Acta 543(4):590\u20134","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"188_CR54","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1006\/cbir.2001.0772","volume":"25","author":"G Cappelletti","year":"2001","unstructured":"Cappelletti G, Pedrotti B, Maggioni MG, Maci R (2001) Microtubule assembly is directly affected by MPP(+)in vitro. Cell Biol Int 25(10):981\u20134","journal-title":"Cell Biol Int"},{"issue":"39","key":"188_CR55","doi-asserted-by":"publisher","first-page":"15136","DOI":"10.1073\/pnas.0807581105","volume":"105","author":"WS Choi","year":"2008","unstructured":"Choi WS, Kruse SE, Palmiter RD, Xia Z (2008) Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci U S A 105(39):15136\u201341. doi: 10.1073\/pnas.0807581105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"40","key":"188_CR56","doi-asserted-by":"crossref","first-page":"34105","DOI":"10.1074\/jbc.M503483200","volume":"280","author":"Y Ren","year":"2005","unstructured":"Ren Y, Liu W, Jiang H, Jiang Q, Feng J (2005) Selective vulnerability of dopaminergic neurons to microtubule depolymerization. J Biol Chem 280(40):34105\u201312","journal-title":"J Biol Chem"},{"issue":"4","key":"188_CR57","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1111\/j.1471-4159.2008.05526.x","volume":"106","author":"Y Liang","year":"2008","unstructured":"Liang Y, Li S, Wen C, Zhang Y, Guo Q, Wang H, Su B (2008) Intrastriatal injection of colchicine induces striatonigral degeneration in mice. J Neurochem 106(4):1815\u201327. doi: 10.1111\/j.1471-4159.2008.05526.x","journal-title":"J Neurochem"},{"issue":"21","key":"188_CR58","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1016\/j.febslet.2005.07.058","volume":"579","author":"G Cappelletti","year":"2005","unstructured":"Cappelletti G, Surrey T, Maci R (2005) The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor. FEBS Lett 579(21):4781\u20136. doi: 10.1016\/j.febslet.2005.07.058","journal-title":"FEBS Lett"},{"issue":"1","key":"188_CR59","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1471-4159.2010.06924.x","volume":"115","author":"D Cartelli","year":"2010","unstructured":"Cartelli D, Ronchi C, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G (2010) Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration. J Neurochem 115(1):247\u201358. doi: 10.1111\/j.1471-4159.2010.06924.x","journal-title":"J Neurochem"},{"key":"188_CR60","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/srep01837","volume":"3","author":"D Cartelli","year":"2013","unstructured":"Cartelli D, Casagrande F, Busceti CL, Bucci D, Molinaro G, Traficante A, Passarella D, Giavini E et al (2013) Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. Sci Rep 3:1837. doi: 10.1038\/srep01837","journal-title":"Sci Rep"},{"issue":"4","key":"188_CR61","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1600-0854.2007.00695.x","volume":"9","author":"OA Shemesh","year":"2008","unstructured":"Shemesh OA, Erez H, Ginzburg I, Spira ME (2008) Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Traffic 9(4):458\u201371. doi: 10.1111\/j.1600-0854.2007.00695.x","journal-title":"Traffic"},{"key":"188_CR62","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.expneurol.2014.04.024","volume":"257","author":"VP Patel","year":"2014","unstructured":"Patel VP, Chu CT (2014) Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson\u2019s disease. Exp Neurol 257:170\u201381. doi: 10.1016\/j.expneurol.2014.04.024","journal-title":"Exp Neurol"},{"issue":"29","key":"188_CR63","doi-asserted-by":"publisher","first-page":"7827","DOI":"10.1523\/JNEUROSCI.1644-07.2007","volume":"27","author":"M Escobar-Khondiker","year":"2007","unstructured":"Escobar-Khondiker M, H\u00f6llerhage M, Muriel MP, Champy P, Bach A, Depienne C, Respondek G, Yamada ES et al (2007) Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. J Neurosci 27(29):7827\u201337. doi: 10.1523\/JNEUROSCI.1644-07.2007","journal-title":"J Neurosci"},{"issue":"19","key":"188_CR64","doi-asserted-by":"publisher","first-page":"7212","DOI":"10.1523\/JNEUROSCI.0711-11.2011","volume":"31","author":"JS Kim-Han","year":"2011","unstructured":"Kim-Han JS, Antenor-Dorsey JA, O\u2019Malley KL (2011) The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J Neurosci 31(19):7212\u201321. doi: 10.1523\/JNEUROSCI.0711-11.2011","journal-title":"J Neurosci"},{"issue":"4","key":"188_CR65","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2004.11.008","volume":"44","author":"J Shen","year":"2004","unstructured":"Shen J (2004) Protein kinases linked to the pathogenesis of Parkinson\u2019s disease. Neuron 44(4):575\u20137","journal-title":"Neuron"},{"issue":"6676","key":"188_CR66","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"T Kitada","year":"1998","unstructured":"Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y et al (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392(6676):605\u20138","journal-title":"Nature"},{"issue":"2","key":"188_CR67","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1074\/jbc.M113.507913","volume":"289","author":"BM Law","year":"2014","unstructured":"Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK et al (2014) A direct interaction between leucine-rich repeat kinase 2 and specific \u03b2-tubulin isoforms regulates tubulin acetylation. J Biol Chem 289(2):895\u2013908. doi: 10.1074\/jbc.M113.507913","journal-title":"J Biol Chem"},{"issue":"5","key":"188_CR68","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1111\/j.1471-4159.2009.06235.x","volume":"110","author":"F Gillardon","year":"2009","unstructured":"Gillardon F (2009) Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability\u2014a point of convergence in parkinsonian neurodegeneration? J Neurochem 110(5):1514\u201322. doi: 10.1111\/j.1471-4159.2009.06235.x","journal-title":"J Neurochem"},{"key":"188_CR69","doi-asserted-by":"publisher","unstructured":"Cartelli D, Goldwurm S, Casagrande F, Pezzoli G, Cappelletti G (2012) Microtubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts. PLoS One 7(5):e37467. doi: 10.1371\/journal.pone.0037467","DOI":"10.1371\/journal.pone.0037467"},{"key":"188_CR70","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.1038\/ncomms6245","volume":"5","author":"VK Godena","year":"2014","unstructured":"Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ et al (2014) Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Nat Commun 5:5245. doi: 10.1038\/ncomms6245","journal-title":"Nat Commun"},{"issue":"6","key":"188_CR71","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.stemcr.2015.11.004","volume":"5","author":"AJ Schwab","year":"2015","unstructured":"Schwab AJ, Ebert AD (2015) Neurite aggregation and calcium dysfunction in iPSC-derived sensory neurons with Parkinson's disease-related LRRK2 G2019S mutation. Stem Cell Reports 5(6):1039\u201352. doi: 10.1016\/j.stemcr.2015.11.004","journal-title":"Stem Cell Reports"},{"issue":"8","key":"188_CR72","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1523\/JNEUROSCI.23-08-03316.2003","volume":"23","author":"Y Ren","year":"2003","unstructured":"Ren Y, Zhao J, Feng J (2003) Parkin binds to alpha\/beta tubulin and increases their ubiquitination and degradation. J Neurosci 23(8):3316\u201324","journal-title":"J Neurosci"},{"issue":"17","key":"188_CR73","doi-asserted-by":"crossref","first-page":"17154","DOI":"10.1074\/jbc.M500843200","volume":"280","author":"F Yang","year":"2005","unstructured":"Yang F, Jiang Q, Zhao J, Ren Y, Sutton MD, Feng J (2005) Parkin stabilizes microtubules through strong binding mediated by three independent domains. J Biol Chem 280(17):17154\u201362","journal-title":"J Biol Chem"},{"issue":"6","key":"188_CR74","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1074\/jbc.M806245200","volume":"284","author":"Y Ren","year":"2009","unstructured":"Ren Y, Jiang H, Yang F, Nakaso K, Feng J (2009) Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation. J Biol Chem 284(6):4009\u201317. doi: 10.1074\/jbc.M806245200","journal-title":"J Biol Chem"},{"issue":"1","key":"188_CR75","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/stem.1854","volume":"33","author":"Y Ren","year":"2015","unstructured":"Ren Y, Jiang H, Hu Z, Fan K, Wang J, Janoschka S, Wang X, Ge S et al (2015) Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons. Stem Cells 33(1):68\u201378. doi: 10.1002\/stem.1854","journal-title":"Stem Cells"},{"issue":"3","key":"188_CR76","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1074\/jbc.M102981200","volume":"277","author":"MA Alim","year":"2002","unstructured":"Alim MA, Hossain MS, Arima K, Takeda K, Izumiyama Y, Nakamura M, Kaji H, Shinoda T et al (2002) Tubulin seeds alpha-synuclein fibril formation. J Biol Chem 277(3):2112\u20137","journal-title":"J Biol Chem"},{"key":"188_CR77","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/neuro.24.005.2009","volume":"1","author":"AR Esteves","year":"2010","unstructured":"Esteves AR, Ardu\u00edno DM, Swerdlow RH, Oliveira CR, Cardoso SM (2010) Microtubule depolymerization potentiates alpha-synuclein oligomerization. Front Aging Neurosci 1:5. doi: 10.3389\/neuro.24.005.2009 , eCollection 2010","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"188_CR78","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.2353\/ajpath.2009.080503","volume":"174","author":"K Nakayama","year":"2010","unstructured":"Nakayama K, Suzuki Y, Yazawa I (2010) Microtubule depolymerization suppresses alpha-synuclein accumulation in a mouse model of multiple system atrophy. Am J Pathol 174(4):1471\u201380. doi: 10.2353\/ajpath.2009.080503","journal-title":"Am J Pathol"},{"issue":"7","key":"188_CR79","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1007\/s11033-009-9899-2","volume":"37","author":"RM Zhou","year":"2010","unstructured":"Zhou RM, Huang YX, Li XL, Chen C, Shi Q, Wang GR, Tian C, Wang ZY et al (2010) Molecular interaction of \u03b1-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells. Mol Biol Rep 37(7):3183\u201392. doi: 10.1007\/s11033-009-9899-2","journal-title":"Mol Biol Rep"},{"issue":"30","key":"188_CR80","doi-asserted-by":"publisher","first-page":"21742","DOI":"10.1074\/jbc.M113.451815","volume":"288","author":"I Prots","year":"2013","unstructured":"Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, B\u00f6hm KJ, Winner B (2013) \u03b1-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem 288(30):21742\u201354. doi: 10.1074\/jbc.M113.451815","journal-title":"J Biol Chem"},{"issue":"4","key":"188_CR81","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-2004-6412","volume":"6","author":"MA Alim","year":"2004","unstructured":"Alim MA, Ma QL, Takeda K, Aizawa T, Matsubara M, Nakamura M, Asada A, Saito T et al (2004) Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein. J Alzheimers Dis 6(4):435\u201342, discussion 443-9","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"188_CR82","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbrc.2007.02.163","volume":"356","author":"L Chen","year":"2007","unstructured":"Chen L, Jin J, Davis J, Zhou Y, Wang Y, Liu J, Lockhart PJ, Zhang J (2007) Oligomeric alpha-synuclein inhibits tubulin polymerization. Biochem Biophys Res Commun 356(3):548\u201353","journal-title":"Biochem Biophys Res Commun"},{"key":"188_CR83","doi-asserted-by":"publisher","first-page":"33289","DOI":"10.1038\/srep33289","volume":"6","author":"D Cartelli","year":"2016","unstructured":"Cartelli D, Aliverti A, Barbiroli A, Santambrogio C, Ragg EM, Casagrande FVM, Cantele F, Beltramone S et al (2016) \u03b1-Synuclein is a novel microtubule dynamase. Sci Rep 6:33289. doi: 10.1038\/srep33289","journal-title":"Sci. Rep"},{"issue":"4","key":"188_CR84","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.cell.2011.10.018","volume":"147","author":"X Wang","year":"2011","unstructured":"Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J et al (2011) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147(4):893\u2013906. doi: 10.1016\/j.cell.2011.10.018","journal-title":"Cell"},{"issue":"2","key":"188_CR85","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neurobiolaging.2012.04.008","volume":"34","author":"C Sheng","year":"2013","unstructured":"Sheng C, Heng X, Zhang G, Xiong R, Li H, Zhang S, Chen S (2013) DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth. Neurobiol Aging 34(2):489\u201398. doi: 10.1016\/j.neurobiolaging.2012.04.008","journal-title":"Neurobiol Aging"},{"issue":"6","key":"188_CR86","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00005072-198811000-00008","volume":"47","author":"PG Galloway","year":"1988","unstructured":"Galloway PG, Grundke-Iqbal I, Iqbal K, Perry G (1988) Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. J Neuropathol Exp Neurol 47(6):654\u201363","journal-title":"J Neuropathol Exp Neurol"},{"key":"188_CR87","first-page":"920","volume-title":"Handbuch der neurologie","author":"FH Lewy","year":"1912","unstructured":"Lewy FH (1912) Paralysis agitans I. Pathologische anatomie. In: Lewandowsky M (ed) Handbuch der neurologie. Springer, Berlin, pp 920\u2013933"},{"issue":"11","key":"188_CR88","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrm1742","volume":"6","author":"CA Ross","year":"2005","unstructured":"Ross CA, Poirier MA (2005) Opinion: what is the role of protein aggregation in neurodegeneration? Nat Rev Mol Cell Biol 6(11):891\u20138","journal-title":"Nat Rev Mol Cell Biol"},{"key":"188_CR89","doi-asserted-by":"publisher","unstructured":"Power JH, Barnes OL, Chegini F (2015) Lewy bodies and the mechanisms of neuronal cell death in parkinson's disease and dementia with Lewy bodies. Brain Pathol 15. doi: 10.1111\/bpa.12344","DOI":"10.1111\/bpa.12344"},{"issue":"Pt 7","key":"188_CR90","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1093\/brain\/aws133","volume":"135","author":"Y Chu","year":"2012","unstructured":"Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH (2012) Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 135(Pt 7):2058\u201373. doi: 10.1093\/brain\/aws133","journal-title":"Brain"},{"issue":"11","key":"188_CR91","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1523\/JNEUROSCI.5427-08.2009","volume":"29","author":"CY Chung","year":"2009","unstructured":"Chung CY, Koprich JB, Siddiqi H, Isacson O (2009) Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci 29(11):3365\u201373. doi: 10.1523\/JNEUROSCI.5427-08.2009","journal-title":"J Neurosci"},{"issue":"7312","key":"188_CR92","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature09324","volume":"467","author":"JS Akella","year":"2010","unstructured":"Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET et al (2010) MEC-17 is an alpha-tubulin acetyltransferase. Nature 467(7312):218\u201322. doi: 10.1038\/nature09324","journal-title":"Nature"},{"issue":"6887","key":"188_CR93","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","volume":"417","author":"C Hubbert","year":"2002","unstructured":"Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF et al (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417(6887):455\u20138","journal-title":"Nature"},{"key":"188_CR94","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1750-1326-8-7","volume":"8","author":"C Sim\u00f5es-Pires","year":"2013","unstructured":"Sim\u00f5es-Pires C, Zwick V, Nurisso A, Schenker E, Carrupt PA, Cuendet M (2013) HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Mol Neurodegener 8:7. doi: 10.1186\/1750-1326-8-7","journal-title":"Mol Neurodegener"},{"issue":"14","key":"188_CR95","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1523\/JNEUROSCI.4486-15.2016","volume":"36","author":"P Gobrecht","year":"2016","unstructured":"Gobrecht P, Andreadaki A, Diekmann H, Heskamp A, Leibinger M, Fischer D (2016) Promotion of functional nerve regeneration by inhibition of microtubule detyrosination. J Neurosci 36(14):3890\u20133902","journal-title":"J Neurosci"},{"issue":"9","key":"188_CR96","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/jnr.23394","volume":"92","author":"V Das","year":"2014","unstructured":"Das V, Sim DA, Miller JH (2014) Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture. J Neurosci Res 92(9):1155\u201366. doi: 10.1002\/jnr.23394","journal-title":"J Neurosci Res"},{"issue":"19","key":"188_CR97","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.2174\/138161212800626193","volume":"8","author":"CD Katsetos","year":"2012","unstructured":"Katsetos CD, Dr\u00e1ber P (2012) Tubulins as therapeutic targets in cancer: from bench to bedside. Curr Pharm Des 8(19):2778\u201392","journal-title":"Curr Pharm Des"},{"issue":"41","key":"188_CR98","doi-asserted-by":"publisher","first-page":"13861","DOI":"10.1523\/JNEUROSCI.3059-10.2010","volume":"30","author":"KR Brunden","year":"2010","unstructured":"Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ et al (2010) Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci 30(41):13861\u20136. doi: 10.1523\/JNEUROSCI.3059-10.2010","journal-title":"J Neurosci"},{"issue":"11","key":"188_CR99","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1523\/JNEUROSCI.4922-11.2012","volume":"32","author":"B Zhang","year":"2012","unstructured":"Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX et al (2012) The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32(11):3601\u201311. doi: 10.1523\/JNEUROSCI.4922-11.2012","journal-title":"J Neurosci"},{"issue":"6019","key":"188_CR100","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1126\/science.1201148","volume":"331","author":"F Hellal","year":"2011","unstructured":"Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D et al (2011) Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 331(6019):928\u201331. doi: 10.1126\/science.1201148","journal-title":"Science"},{"issue":"6232","key":"188_CR101","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1126\/science.aaa2958","volume":"348","author":"J Ruschel","year":"2015","unstructured":"Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C et al (2015) Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science 348(6232):347\u201352. doi: 10.1126\/science.aaa2958","journal-title":"Science"},{"issue":"3","key":"188_CR102","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.mcn.2010.12.011","volume":"46","author":"SM Fleming","year":"2011","unstructured":"Fleming SM, Mulligan CK, Richter F, Mortazavi F, Lemesre V, Frias C, Zhu C, Stewart A et al (2011) A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions. Mol Cell Neurosci 46(3):597\u2013606. doi: 10.1016\/j.mcn.2010.12.011","journal-title":"Mol Cell Neurosci"},{"issue":"5","key":"188_CR103","doi-asserted-by":"publisher","first-page":"e00065","DOI":"10.1002\/prp2.65","volume":"2","author":"I Magen","year":"2014","unstructured":"Magen I, Ostritsky R, Richter F, Zhu C, Fleming SM, Lemesre V, Stewart AJ, Morimoto BH et al (2014) Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing \u03b1-synuclein. Pharmacol Res Perspect 2(5):e00065. doi: 10.1002\/prp2.65","journal-title":"Pharmacol Res Perspect"},{"issue":"1","key":"188_CR104","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.bbadis.2013.10.003","volume":"1842","author":"AR Esteves","year":"2014","unstructured":"Esteves AR, Gozes I, Cardoso SM (2014) The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease. Biochim Biophys Acta 1842(1):7\u201321. doi: 10.1016\/j.bbadis.2013.10.003","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 1","key":"188_CR105","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.3233\/JAD-131664","volume":"40","author":"I Gozes","year":"2014","unstructured":"Gozes I, Iram T, Maryanovsky E, Arviv C, Rozenberg L, Schirer Y, Giladi E, Furman-Assaf S (2014) Novel tubulin and tau neuroprotective fragments sharing structural similarities with the drug candidate NAP (davunetide). J Alzheimers Dis 40(Suppl 1):S23\u201336. doi: 10.3233\/JAD-131664","journal-title":"J Alzheimers Dis"},{"key":"188_CR106","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nchem.401","volume":"8","author":"S Pieraccini","year":"2009","unstructured":"Pieraccini S, Saladino G, Cappelletti G, Cartelli D, Francescato P, Speranza G, Manitto P, Sironi M (2009) In silico design of tubulin-targeted antimitotic peptides. Nat Chem 8:642\u20138. doi: 10.1038\/nchem.401","journal-title":"Nat Chem"},{"key":"188_CR107","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3389\/fnins.2015.00403","volume":"9","author":"CA Lazzara","year":"2015","unstructured":"Lazzara CA, Kim YH (2015) Potential application of lithium in Parkinson's and other neurodegenerative diseases. Front Neurosci 9:403. doi: 10.3389\/fnins.2015.00403 , eCollection 2015","journal-title":"Front Neurosci"},{"issue":"Pt 5","key":"188_CR108","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1042\/BST0320799","volume":"32","author":"R Williams","year":"2004","unstructured":"Williams R, Ryves WJ, Dalton EC, Eickholt B, Shaltiel G, Agam G, Harwood AJ (2004) A molecular cell biology of lithium. Biochem Soc Trans 32(Pt 5):799\u2013802","journal-title":"Biochem Soc Trans"},{"issue":"10","key":"188_CR109","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/pro.5560051008","volume":"5","author":"J Wolff","year":"1996","unstructured":"Wolff J, Sackett DL, Knipling L (1996) Cation selective promotion of tubulin polymerization by alkali metal chlorides. Protein Sci 5(10):2020\u20138","journal-title":"Protein Sci"},{"issue":"2","key":"188_CR110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0006-291X(76)90719-1","volume":"73","author":"B Bhattacharyya","year":"1976","unstructured":"Bhattacharyya B, Wolff J (1976) Stabilization of microtubules by lithium ion. Biochem Biophys Res Commun 73(2):383\u201390","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"188_CR111","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00795-014-0076-x","volume":"48","author":"T Nakakura","year":"2015","unstructured":"Nakakura T, Asano-Hoshino A, Suzuki T, Arisawa K, Tanaka H, Sekino Y, Kiuchi Y, Kawai K et al (2015) The elongation of primary cilia via the acetylation of \u03b1-tubulin by the treatment with lithium chloride in human fibroblast KD cells. Med Mol Morpho 48(1):44\u201353. doi: 10.1007\/s00795-014-0076-x","journal-title":"Med Mol Morpho"},{"issue":"48","key":"188_CR112","doi-asserted-by":"publisher","first-page":"18746","DOI":"10.1073\/pnas.0806303105","volume":"105","author":"TK Rostovtseva","year":"2008","unstructured":"Rostovtseva TK, Sheldon KL, Hassanzadeh E, Monge C, Saks V, Bezrukov SM, Sackett DL (2008) Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proc Natl Acad Sci U S A 105(48):18746\u201351. doi: 10.1073\/pnas.0806303105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"188_CR113","doi-asserted-by":"publisher","first-page":"10192","DOI":"10.1158\/0008-5472.CAN-10-2429","volume":"70","author":"EN Maldonado","year":"2010","unstructured":"Maldonado EN, Patnaik J, Mullins MR, Lemasters JJ (2010) Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res 70(24):10192\u2013201. doi: 10.1158\/0008-5472.CAN-10-2429","journal-title":"Cancer Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-0188-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0188-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0188-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T15:43:45Z","timestamp":1657467825000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-0188-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":113,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["188"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-0188-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]}}}