{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:18:34Z","timestamp":1793387914030,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271323"],"award-info":[{"award-number":["81271323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371182"],"award-info":[{"award-number":["31371182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s12035-016-0249-9","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T02:49:06Z","timestamp":1479091746000},"page":"7762-7776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1\/ICAM-1 Interaction in a Mouse Model of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"54","author":[{"given":"Zhan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Bei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"249_CR1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00702-010-0428-1","volume":"117","author":"L Qian","year":"2010","unstructured":"Qian L, Flood PM, Hong JS (2010) Neuroinflammation is a key player in Parkinson\u2019s disease and a prime target for therapy. J Neural Transm 117:971\u2013979","journal-title":"J Neural Transm"},{"key":"249_CR2","first-page":"182","volume":"119","author":"V Brochard","year":"2009","unstructured":"Brochard V, Combadi\u00e8re B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D et al (2009) Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119:182\u2013192","journal-title":"J Clin Invest"},{"key":"249_CR3","doi-asserted-by":"crossref","first-page":"e1376","DOI":"10.1371\/journal.pone.0001376","volume":"3","author":"EJ Benner","year":"2008","unstructured":"Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, Tsiperson V, Nemachek C, Ciborowski P et al (2008) Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One 3:e1376","journal-title":"PLoS One"},{"key":"249_CR4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","volume":"448","author":"T Korn","year":"2007","unstructured":"Korn T, Bettelli E, Gao W, Awasthi A, J\u00e4ger A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484\u2013487","journal-title":"Nature"},{"key":"249_CR5","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","volume":"361","author":"P Miossec","year":"2009","unstructured":"Miossec P, Korn T, Kuchroo VK (2009) Interleukin-17 and type 17 helper T cells. N Engl J Med 361:888\u2013898","journal-title":"N Engl J Med"},{"key":"249_CR6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","volume":"13","author":"M Noack","year":"2014","unstructured":"Noack M, Miossec P (2014) Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 13:668\u2013677","journal-title":"Autoimmun Rev"},{"key":"249_CR7","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1523\/JNEUROSCI.23-15-06181.2003","volume":"23","author":"HM Gao","year":"2003","unstructured":"Gao HM, Liu B, Hong JS (2003) Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 23:6181\u20136187","journal-title":"J Neurosci"},{"key":"249_CR8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","volume":"8","author":"ML Block","year":"2007","unstructured":"Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57\u201369","journal-title":"Nat Rev Neurosci"},{"key":"249_CR9","doi-asserted-by":"crossref","first-page":"e57307","DOI":"10.1371\/journal.pone.0057307","volume":"8","author":"J Zimmermann","year":"2013","unstructured":"Zimmermann J, Krauthausen M, Hofer MJ, Heneka MT, Campbell IL, M\u00fcller M (2013) CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia. PLoS One 8:e57307","journal-title":"PLoS One"},{"key":"249_CR10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00401-015-1402-7","volume":"129","author":"A Waisman","year":"2015","unstructured":"Waisman A, Hauptmann J, Regen T (2015) The role of IL-17 in CNS diseases. Acta Neuropathol 129:625\u2013637","journal-title":"Acta Neuropathol"},{"key":"249_CR11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bjp.0707167","volume":"150","author":"PS Whitton","year":"2007","unstructured":"Whitton PS (2007) Inflammation as a causative factor in the aetiology of Parkinson\u2019s disease. Br J Pharmacol 150:963\u2013976","journal-title":"Br J Pharmacol"},{"key":"249_CR12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","volume":"129","author":"S Amor","year":"2010","unstructured":"Amor S, Puentes F, Baker D, van der Valk P (2010) Inflammation in neurodegenerative diseases. Immunology 129:154\u2013169","journal-title":"Immunology"},{"key":"249_CR13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.it.2009.09.003","volume":"31","author":"SH Appel","year":"2010","unstructured":"Appel SH, Beers DR, Henkel JS (2010) T cell-microglial dialogue in Parkinson\u2019s disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol 31:7\u201317","journal-title":"Trends Immunol"},{"key":"249_CR14","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140:918\u2013934","journal-title":"Cell"},{"key":"249_CR15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1742-2094-11-47","volume":"11","author":"RP Liu","year":"2014","unstructured":"Liu RP, Zou M, Wang JY, Zhu JJ, Lai JM, Zhou LL, Chen SF, Zhang X et al (2014) Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation 11:47","journal-title":"J Neuroinflammation"},{"key":"249_CR16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-2094-11-52","volume":"11","author":"I Russo","year":"2014","unstructured":"Russo I, Bubacco L, Greggio E (2014) LRRK2 and neuroinflammation: partners in crime in Parkinson\u2019s disease? J Neuroinflammation 11:52","journal-title":"J Neuroinflammation"},{"key":"249_CR17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneuroim.2007.11.006","volume":"194","author":"J Kawanokuchi","year":"2008","unstructured":"Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A (2008) Production and functions of IL-17 in microglia. J Neuroimmunol 194:54\u201361","journal-title":"J Neuroimmunol"},{"key":"249_CR18","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1084\/jem.20041850","volume":"201","author":"M Semmrich","year":"2005","unstructured":"Semmrich M, Smith A, Feterowski C, Beer S, Engelhardt B, Busch DH, Bartsch B, Laschinger M et al (2005) Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med 201:1987\u20131998","journal-title":"J Exp Med"},{"key":"249_CR19","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1242\/jcs.00876","volume":"116","author":"N Hogg","year":"2003","unstructured":"Hogg N, Laschinger M, Giles K, McDowall A (2003) T-cell integrins: more than just sticking points. J Cell Sci 116:4695\u20134705","journal-title":"J Cell Sci"},{"key":"249_CR20","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1073\/pnas.0502467102","volume":"102","author":"N Anikeeva","year":"2005","unstructured":"Anikeeva N, Somersalo K, Sims TN, Thomas VK, Dustin ML, Sykulev Y (2005) Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A 102:6437\u20136442","journal-title":"Proc Natl Acad Sci U S A"},{"key":"249_CR21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12950-014-0035-2","volume":"11","author":"L Jing","year":"2014","unstructured":"Jing L, Wang JG, Zhang JZ, Cao CX, Chang Y, Dong JD, Guo FY, Li PA (2014) Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury. J Inflamm (Lond) 11:35","journal-title":"J Inflamm (Lond)"},{"key":"249_CR22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/35007098","volume":"404","author":"E Bianchi","year":"2000","unstructured":"Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R (2000) Integrin LFA-1 interacts with the transcriptional coactivator JAB1 to modulate AP-1 activity. Nature 404:617\u2013621","journal-title":"Nature"},{"key":"249_CR23","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ni984","volume":"4","author":"OD Perez","year":"2003","unstructured":"Perez OD, Mitchell D, Jager GC, South S, Murriel C, McBride J, Herzenberg LA, Kinoshita S et al (2003) Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat Immunol 4:1083\u20131092","journal-title":"Nat Immunol"},{"key":"249_CR24","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/ni1103-1052","volume":"4","author":"Y Shimizu","year":"2003","unstructured":"Shimizu Y (2003) LFA-1: more than just T cell velcro. Nat Immunol 4:1052\u20131054","journal-title":"Nat Immunol"},{"key":"249_CR25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1046\/j.1471-4159.2001.00183.x","volume":"76","author":"S Przedborski","year":"2001","unstructured":"Przedborski S, Jackson-Lewis V, Naini AB, Jakowec M, Petzinger G, Miller R, Akram M (2001) The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP): a technical review of its utility and safety. J Neurochem 76:1265\u20131274","journal-title":"J Neurochem"},{"key":"249_CR26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.nbd.2006.07.019","volume":"24","author":"N Marchi","year":"2006","unstructured":"Marchi N, Guiso G, Caccia S, Rizzi M, Gagliardi B, No\u00e9 F, Ravizza T, Bassanini S et al (2006) Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development. Neurobiol Dis 24:429\u2013442","journal-title":"Neurobiol Dis"},{"key":"249_CR27","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1523\/JNEUROSCI.0143-07.2008","volume":"28","author":"HM Gao","year":"2008","unstructured":"Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM (2008) Neuroinflammation and oxidation\/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J Neurosci 28:7687\u20137698","journal-title":"J Neurosci"},{"key":"249_CR28","volume-title":"The mouse brain in stereotaxic coordinates","author":"KBJ Franklin","year":"2007","unstructured":"Franklin KBJ, Paxinos G (2007) The mouse brain in stereotaxic coordinates, Third edn. Academic Press, Elsevier, New York","edition":"Third"},{"key":"249_CR29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4049\/jimmunol.171.1.368","volume":"171","author":"F Giuliani","year":"2003","unstructured":"Giuliani F, Goodyer CG, Antel JP, Yong VW (2003) Vulnerability of human neurons to T cell-mediated cytotoxicity. J Immunol 171:368\u2013379","journal-title":"J Immunol"},{"key":"249_CR30","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/0006-2952(89)90488-7","volume":"38","author":"RS Duman","year":"1989","unstructured":"Duman RS, Terwilliger RZ, Nestler EJ, Tallman JF (1989) Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain. Biochem Pharmacol 38:1909\u20131914","journal-title":"Biochem Pharmacol"},{"key":"249_CR31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","volume":"39","author":"W Dauer","year":"2003","unstructured":"Dauer W, Przedborski S (2003) Parkinson\u2019s disease: mechanisms and models. Neuron 39:889\u2013909","journal-title":"Neuron"},{"key":"249_CR32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.10.034","volume":"197","author":"J Miklossy","year":"2006","unstructured":"Miklossy J, Doudet DD, Schwab C, Yu S, McGeer EG, McGeer PL (2006) Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Exp Neurol 197:275\u2013283","journal-title":"Exp Neurol"},{"key":"249_CR33","doi-asserted-by":"crossref","first-page":"e75786","DOI":"10.1371\/journal.pone.0075786","volume":"8","author":"J Zhang","year":"2013","unstructured":"Zhang J, Ke KF, Liu Z, Qiu YH, Peng YP (2013) Th17 cell-mediated neuroinflammation is involved in neurodegeneration of a\u03b21-42-induced Alzheimer\u2019s disease model rats. PLoS One 8:e75786","journal-title":"PLoS One"},{"key":"249_CR34","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","volume":"13","author":"H Kebir","year":"2007","unstructured":"Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N et al (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13:1173\u20131175","journal-title":"Nat Med"},{"key":"249_CR35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2010.03.004","volume":"32","author":"Z Kang","year":"2010","unstructured":"Kang Z, Altuntas CZ, Gulen MF, Liu C, Giltiay N, Qin H, Liu L, Qian W et al (2010) Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 32:414\u2013425","journal-title":"Immunity"},{"key":"249_CR36","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1073\/pnas.0400983101","volume":"101","author":"FA Verreck","year":"2004","unstructured":"Verreck FA, de Boer T, Langenberg DM, Hoeve MA, Kramer M, Vaisberg E, Kastelein R, Kolk A et al (2004) Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria. Proc Natl Acad Sci U S A 101:4560\u20134565","journal-title":"Proc Natl Acad Sci U S A"},{"key":"249_CR37","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nature01355","volume":"421","author":"DJ Cua","year":"2003","unstructured":"Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W et al (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744\u2013748","journal-title":"Nature"},{"key":"249_CR38","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nn.3505","volume":"16","author":"Z Kang","year":"2013","unstructured":"Kang Z, Wang C, Zepp J, Wu L, Sun K, Zhao J, Chandrasekharan U, DiCorleto PE et al (2013) Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. Nat Neurosci 16:1401\u20131408","journal-title":"Nat Neurosci"},{"key":"249_CR39","doi-asserted-by":"publisher","unstructured":"Zhu Y, Chen X, Liu Z, Peng YP, Qiu YH (2015) Interleukin-10 protection against lipopolysaccharide-induced neuro-inflammation and neurotoxicity in ventral mesencephalic cultures. Int J Mol Sci 17. doi: 10.3390\/ijms17010025","DOI":"10.3390\/ijms17010025"},{"key":"249_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0290-6","author":"SW Lim","year":"2016","unstructured":"Lim SW, Shiue YL, Liao JC, Wee HY, Wang CC, Chio CC, Chang CH, Hu CY et al (2016) Simvastatin therapy in the acute stage of traumatic brain injury attenuates brain trauma-induced depression-like behavior in rats by reducing neuroinflammation in the hippocampus. Neurocrit Care. doi: 10.1007\/s12028-016-0290-6","journal-title":"Neurocrit Care"},{"key":"249_CR41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuroscience.2011.07.046","volume":"194","author":"AR Carta","year":"2011","unstructured":"Carta AR, Frau L, Pisanu A, Wardas J, Spiga S, Carboni E (2011) Rosiglitazone decreases peroxisome proliferator receptor-\u03b3 levels in microglia and inhibits TNF-\u03b1 production: new evidences on neuroprotection in a progressive Parkinson\u2019s disease model. Neuroscience 194:250\u2013261","journal-title":"Neuroscience"},{"key":"249_CR42","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.0803982","volume":"182","author":"AD Reynolds","year":"2009","unstructured":"Reynolds AD, Stone DK, Mosley RL, Gendelman HE (2009) Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets. J Immunol 182:4137\u20134149","journal-title":"J Immunol"},{"key":"249_CR43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.immuni.2010.08.018","volume":"33","author":"V Siffrin","year":"2010","unstructured":"Siffrin V, Radbruch H, Glumm R, Niesner R, Paterka M, Herz J, Leuenberger T, Lehmann SM et al (2010) In vivo imaging of partially reversible Th17 cell-induced neuronal dysfunction in the course of encephalomyelitis. Immunity 33:424\u2013436","journal-title":"Immunity"},{"key":"249_CR44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ni.f.215","volume":"9","author":"M Huse","year":"2008","unstructured":"Huse M, Quann EJ, Davis MM (2008) Shouts, whispers and the kiss of death: directional secretion in T cells. Nat Immunol 9:1105\u20131111","journal-title":"Nat Immunol"},{"key":"249_CR45","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bbi.2009.09.008","volume":"24","author":"CH Nijboer","year":"2010","unstructured":"Nijboer CH, van der Kooij MA, van Bel F, Ohl F, Heijnen CJ, Kavelaars A (2010) Inhibition of the JNK\/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury. Brain Behav Immun 24:812\u2013821","journal-title":"Brain Behav Immun"},{"key":"249_CR46","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1046\/j.1471-4159.2000.0751200.x","volume":"75","author":"MS Saporito","year":"2000","unstructured":"Saporito MS, Thomas BA, Scott RW (2000) MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J Neurochem 75:1200\u20131208","journal-title":"J Neurochem"},{"key":"249_CR47","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1073\/pnas.181182298","volume":"98","author":"XG Xia","year":"2001","unstructured":"Xia XG, Harding T, Weller M, Bieneman A, Uney JB, Schulz JB (2001) Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson\u2019s disease. Proc Natl Acad Sci U S A 98:10433\u201310438","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-0249-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0249-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0249-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T10:59:33Z","timestamp":1568545173000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-0249-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["249"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-0249-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}