{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:51:59Z","timestamp":1787241119702,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/RLF\/Re-entry\/08\/2013"],"award-info":[{"award-number":["BT\/RLF\/Re-entry\/08\/2013"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2016\/000716"],"award-info":[{"award-number":["EMR\/2016\/000716"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12035-016-0373-6","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T03:36:26Z","timestamp":1484278586000},"page":"1019-1025","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Molecular Neuro-Pathomechanism of Neurocysticercosis: How Host Genetic Factors Influence Disease Susceptibility"],"prefix":"10.1007","volume":"55","author":[{"given":"Naina","family":"Arora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Sao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosenjit","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"373_CR1","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S1474-4422(14)70094-8","volume":"13","author":"HH Garcia","year":"2014","unstructured":"Garcia HH, Nash TE, Del Brutto OH (2014) Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13:1202\u20131215","journal-title":"Lancet Neurol"},{"key":"373_CR2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12038-008-0075-y","volume":"33","author":"KN Prasad","year":"2008","unstructured":"Prasad KN, Prasad A, Verma A, Singh AK (2008) Human cysticercosis in India: a review. J Biosciences 33:571\u2013582","journal-title":"J Biosciences"},{"key":"373_CR3","unstructured":"World Health Organization yearly report [2015] http:\/\/www.who.int\/mediacentre\/factsheets\/fs376\/en\/"},{"key":"373_CR4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4269\/ajtmh.2005.72.3","volume":"72","author":"HH Garcia","year":"2005","unstructured":"Garcia HH, Del Brutto OH, Nash TE, White AC, Tsang VCW, Gilman RH (2005) New concepts in the diagnosis and management of neurocysticercosis (Taenia solium). AmJTrop Med Hyg 72:3\u20139","journal-title":"AmJTrop Med Hyg"},{"key":"373_CR5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/clinids\/24.2.101","volume":"24","author":"AC White Jr","year":"1997","unstructured":"White AC Jr (1997) Neurocysticercosis: a major cause of neurological disease worldwide. Clin Infect Dis 24:101\u2013103","journal-title":"Clin Infect Dis"},{"key":"373_CR6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.parint.2007.12.001","volume":"55","author":"A Prasad","year":"2008","unstructured":"Prasad A, Gupta RK, Pradhan S, Tripathi M, Pandey CM, Luthara G, Prasad KN (2008) What triggers seizures in neurocysticercosis? A MRI-based study in pig farming community from a district of North India. Parasitol Int 55:166\u2013171","journal-title":"Parasitol Int"},{"key":"373_CR7","unstructured":"WHO [1983] Guidelines for surveillance prevention and control of taeniasis\/cysticercosis. World Health Organization: Geneva VPH\/83.49"},{"key":"373_CR8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.trstmh.2008.07.015","volume":"103","author":"KN Prasad","year":"2009","unstructured":"Prasad KN, Prasad A, Gupta RK, Nath K, Pradhan S, Tripathi M, Pandey CM (2009) Neurocysticercosis in patients with active epilepsy from the pig farming community of Lucknow district, North India. Trans R Soc Trop Med Hyg 103:144\u2013150","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"373_CR9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4269\/ajtmh.1995.52.145","volume":"52","author":"HH Garcia","year":"1995","unstructured":"Garcia HH, Gilman RH, Tovar MA, Flores E, Jo R, Tsang VC et al (1995) For the cysticercosis working group of Peru. Factors associated with Taenia solium cysticercosis: analysis of nine hundred forty six Peruvian neurologic patients. AmJTrop Med Hyg 52:145\u2013148","journal-title":"AmJTrop Med Hyg"},{"key":"373_CR10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0035-9203(94)90493-6","volume":"88","author":"E Sarti","year":"1994","unstructured":"Sarti E, Schantz PM, Plancarte A, Wilson M, Gutierrez OI, Aguil-era J et al (1994) Epidemiological investigation of Taenia solium taeniasis and cysticercosis in a rural village of Michoacan state, Mexico. Trans R Soc Trop Med Hyg 88:49\u201352","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"373_CR11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrg1767","volume":"7","author":"L Feuk","year":"2006","unstructured":"Feuk L, Carson AR, Scherer SW (2006) Structural variation in the human genome. Nat Rev Genet 7:85\u201397","journal-title":"Nat Rev Genet"},{"key":"373_CR12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2217\/fmb.15.37","volume":"10","author":"M Jaeger","year":"2015","unstructured":"Jaeger M, Stappers MH, Joosten LA, Gyssens IC, Netea MG (2015) Genetic variation in pattern recognition receptors: functional consequences and susceptibility to infectious disease. Future Microbiol 10:989\u20131008","journal-title":"Future Microbiol"},{"key":"373_CR13","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/1469-0691.12800","volume":"20","author":"ZD Pana","year":"2014","unstructured":"Pana ZD, Farmaki E, Roilides E (2014) Host genetics and opportunistic fungal infections. Clin Microbiol Infect 20:1254\u20131264","journal-title":"Clin Microbiol Infect"},{"key":"373_CR14","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s00439-014-1457-x","volume":"133","author":"EJ Hollox","year":"2014","unstructured":"Hollox EJ, Hoh BP (2014) Human gene copy number variation and infectious disease. Hum Genet 133:1217\u20131233","journal-title":"Hum Genet"},{"key":"373_CR15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1744-313X.1989.tb00491.x","volume":"16","author":"V Trejo","year":"1989","unstructured":"Trejo V, Talamas O, Granados G, Castro L, Rabiela MT, Sotelo J, Gorodezky C (1989) What is the significance of the presence of MHC molecules on the surface of parasites in human neurocysticercosis? J Immunogenet 16:427\u2013436","journal-title":"J Immunogenet"},{"key":"373_CR16","first-page":"85","volume":"63","author":"OH Del Brutto","year":"1991","unstructured":"Del Brutto OH, Grandos G, Talamas O, Sotelo J (1991) Genetic pattern of the HLA system HLA A, B, C, DR, DQ antigens in Mexican patients with parenchymal brain cysticercosis. Hum Biol 63:85\u201393","journal-title":"Hum Biol"},{"key":"373_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0896-6974(96)00075-8","volume":"10","author":"S Jain","year":"1997","unstructured":"Jain S, Padma MV, Kanga U, Mehra NK, Puri A, Maheswari MC (1997) Human leukocyte antigen studies in Indian probands with seizures associated with single small enhancing computed tomography lesions and seizure types in their family members. J Epilepsy 10:55\u201361","journal-title":"J Epilepsy"},{"key":"373_CR18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1528-1157.1999.tb02080.x","volume":"40","author":"S Jain","year":"1999","unstructured":"Jain S, Padma MV, Kanga U, Mehra NK, Puri A, Maheshwari MC (1999) Family studies and human leukocyte antigen class II typing in Indian probands with seizures in association with single small enhancing computed tomography lesions. Epilepsia 40:232\u2013238","journal-title":"Epilepsia"},{"key":"373_CR19","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.4049\/jimmunol.171.11.5837","volume":"171","author":"PG Thomas","year":"2003","unstructured":"Thomas PG, Carter MR, Atochina O, Da'Dara AA, Piskorska D, McGuire E, Harn DA (2003) Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism. J Immunol 171:5837\u20135841","journal-title":"J Immunol"},{"key":"373_CR20","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/intimm\/dxg108","volume":"15","author":"HS Mun","year":"2003","unstructured":"Mun HS, Aosai F, Norose K, Chen M, Piao LX, Takeuchi O et al (2003) TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. Int Immunol 15:1081\u20131087","journal-title":"Int Immunol"},{"key":"373_CR21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jneuroim.2006.07.019","volume":"181","author":"BB Mishra","year":"2006","unstructured":"Mishra BB, Mishra PK, Teale JM (2006) Expression and distribution of Toll like receptors in the brain during neurocysticercosis. J Neuroimmunol 181:46\u201356","journal-title":"J Neuroimmunol"},{"key":"373_CR22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1086\/656395","volume":"202","author":"A Verma","year":"2010","unstructured":"Verma A, Prasad KN, Gupta RK, Singh AK, Nyati KK, Rizwan A et al (2010) Toll-like receptor 4 polymorphism and its association with symptomatic neurocysticercosis. J Infect Dis 202:1219\u20131225","journal-title":"J Infect Dis"},{"key":"373_CR23","doi-asserted-by":"crossref","first-page":"16645","DOI":"10.1073\/pnas.0704828104","volume":"104","author":"B Ferwerda","year":"2007","unstructured":"Ferwerda B, McCall MB, Alonso S, Giamarellos-Bourboulis EJ, Mouktaroudi M, Izagirre N et al (2007) TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A 104:16645\u201316650","journal-title":"Proc Natl Acad Sci U S A"},{"key":"373_CR24","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1128\/IAI.69.7.4554-4560.2001","volume":"69","author":"IB Restrepo","year":"2001","unstructured":"Restrepo IB, Alvarez JI, Castano JA, Arias LF, Restrepo M, Trujillo J et al (2001) Brain granuloma in neurocysticercosis patients are associated with a Th1 and Th2 profile. Infect Immun 69:4554\u20134560","journal-title":"Infect Immun"},{"key":"373_CR25","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.ijpara.2013.07.009","volume":"43","author":"AK Singh","year":"2013","unstructured":"Singh AK, Prasad KN, Prasad A, Tripathi M, Gupta RK, Husain N (2013) Immune responses to viable and degenerative metacestodes of Taenia solium in naturally infected swine. Int J Parasitol 43:1101\u201311017","journal-title":"Int J Parasitol"},{"key":"373_CR26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jneuroim.2008.09.015","volume":"206","author":"A Prasad","year":"2009","unstructured":"Prasad A, Prasad KN, Gupta RK, Pradhan S (2009) Increased expression of ICAM-1 among symptomatic neurocysticercosis. J Neuroimmunol 206:118\u2013120","journal-title":"J Neuroimmunol"},{"key":"373_CR27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exppara.2010.11.006","volume":"127","author":"A Prasad","year":"2011","unstructured":"Prasad A, Prasad KN, Gupta RK, Tripathi S, Jha S, Paliwal VK et al (2011) Immune response to different fractions of Taenia solium cyst fluid antigens in patients with neurocysticercosis. Exp Parasitol 127:687\u2013692","journal-title":"Exp Parasitol"},{"key":"373_CR28","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/pim.12351","volume":"38","author":"J Tharmalingam","year":"2016","unstructured":"Tharmalingam J, Prabhakar AT, Gangadaran P, Dorny P, Vercruysse J, Geldhof P et al (2016) Host Th1\/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis. Parasite Immunol 38:628\u2013634","journal-title":"Parasite Immunol"},{"key":"373_CR29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/pim.12299","volume":"38","author":"A Fleury","year":"2016","unstructured":"Fleury A, Cardenas G, Adalid-Peralta L, Fragoso G, Sciutto E (2016) Immunopathology in Taenia solium neurocysticercosis. Parasite Immunol 38:147\u2013157","journal-title":"Parasite Immunol"},{"key":"373_CR30","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.micinf.2005.11.005","volume":"8","author":"A Chavarria","year":"2006","unstructured":"Chavarria A, Fleury A, Bobes RJ, Morales J, Fragoso G, Sciutoo EA (2006) Depressed peripheral cellular immune response is related to symptomatic neurocysticercosis. Microbes Infect 8:1082\u20131089","journal-title":"Microbes Infect"},{"key":"373_CR31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","volume":"346","author":"TA Springer","year":"1990","unstructured":"Springer TA (1990) Adhesion receptors of immune system. Nature 346:425\u2013434","journal-title":"Nature"},{"key":"373_CR32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","volume":"76","author":"TA Springer","year":"1994","unstructured":"Springer TA (1994) Traffic signals for the lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301\u2013314","journal-title":"Cell"},{"key":"373_CR33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-4615-2492-2_22","volume":"355","author":"P Joling","year":"1994","unstructured":"Joling P, Boom S, Johnson J, Dekker ME, van den Tweel JG, Schuurman HJ et al (1994) Domain 5 of the intercellular adhesion molecule-1 (ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells. Adv Exp Med Biol 355:131\u2013135","journal-title":"Adv Exp Med Biol"},{"key":"373_CR34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jneuroim.2014.07.018","volume":"276","author":"A Singh","year":"2014","unstructured":"Singh A, Singh AK, Singh SK, Paliwal VK, Gupta RK, Prasad KN (2014) Association of ICAM-1 K469E polymorphism with neurocysticercosis. J Neuroimmunol 276:166\u2013171","journal-title":"J Neuroimmunol"},{"key":"373_CR35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0198-8859(02)00825-X","volume":"64","author":"S Nejentsev","year":"2003","unstructured":"Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J et al (2003) Intercellular adhesion molecule- 1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol 64:345\u2013349","journal-title":"Hum Immunol"},{"key":"373_CR36","first-page":"187","volume":"8","author":"A Papa","year":"2004","unstructured":"Papa A, Danese S, Urgesi R, Grillo A, Guglielmo S, Roberto I et al (2004) Intercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease. Eur Rev Med Pharmacol Sci 8:187\u2013191","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"373_CR37","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.182.5.1231","volume":"182","author":"J Miller","year":"1995","unstructured":"Miller J, Knorr R, Ferrone M, Houdei R, Carron CP, Dustin ML (1995) Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1. J Exp Med 182:1231\u20131241","journal-title":"J Exp Med"},{"key":"373_CR38","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.95.8.4134","volume":"95","author":"JM Casasnovas","year":"1998","unstructured":"Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA (1998) A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proc Natl Acad Sci U S A 95:4134\u20134139","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"373_CR39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/ijerph13040379","volume":"13","author":"AL Hollman","year":"2016","unstructured":"Hollman AL, Tchounwou PB, Huang HC (2016) The association between gene-environment interactions and diseases involving the human GST superfamily with SNP variants. Int J Environ Res Public Health 13(4):379","journal-title":"Int J Environ Res Public Health"},{"key":"373_CR40","unstructured":"Singh A, Prasad KN, Singh AK, Singh SK, Gupta KK, Paliwal VK et al (2016) Human glutathione S-transferase enzyme gene polymorphisms and their association with neurocysticercosis. Mol Neurobiol 2016"},{"key":"373_CR41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1073\/pnas.0506803102","volume":"103","author":"FP Mockenhaupt","year":"2006","unstructured":"Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, Eckert J et al (2006) Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A 103:177\u2013182","journal-title":"Proc Natl Acad Sci U S A"},{"key":"373_CR42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4269\/ajtmh.1995.52.145","volume":"52","author":"Garcia HH, Gilman RH, Tovar MA, Flores E, Jo R, Tsang VC, Diaz F, Torres P, Miranda E for the cysticercosis working group of Peru","year":"1995","unstructured":"Garcia HH, Gilman RH, Tovar MA, Flores E, Jo R, Tsang VC, Diaz F, Torres P, Miranda E for the cysticercosis working group of Peru (1995) Factors associated with Taenia solium cysticercosis: analysis of nine hundred forty six Peruvian neurologic patients. AmJTrop Med Hyg 52:145\u2013148","journal-title":"AmJTrop Med Hyg"},{"key":"373_CR43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4269\/ajtmh.1992.46.677","volume":"46","author":"E Sarti","year":"1992","unstructured":"Sarti E, Schantz PM, Plancarte A, Wilson M, Gutierrez O, Aguilera J, Roberts J, Flisser A (1992) Prevalence and risk factors for Taenia solium taeniasis and cysticercosis in humans and pigs in a village in Morelos, Mexico. AmJTrop Med Hyg 46:677\u2013685","journal-title":"AmJTrop Med Hyg"},{"key":"373_CR44","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1212\/01.wnl.0000168828.83461.09","volume":"65","author":"SM Montano","year":"2005","unstructured":"Montano SM, Villaran MV, Ylquimiche L, Figueroa JJ, Rodriguez S, Bautista CT et al (2005) Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology 65:229\u2013233","journal-title":"Neurology"},{"key":"373_CR45","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.trstmh.2007.04.019","volume":"101","author":"KN Prasad","year":"2007","unstructured":"Prasad KN, Prasad A, Gupta RK, Pandey CM, Singh U (2007) Prevalence and associated risk factors of Taenia solium taeniasis in a rural pig farming community of North India. Trans R Soc Trop Med Hyg 101:1241\u20131247","journal-title":"Trans R Soc Trop Med Hyg"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-0373-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0373-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-0373-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T09:49:58Z","timestamp":1568713798000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-0373-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["373"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-0373-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}