{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:45:32Z","timestamp":1793731532872,"version":"4.6.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of Gansu, China","award":["No. 1506RJZA222"],"award-info":[{"award-number":["No. 1506RJZA222"]}]},{"name":"Lanzhou Science and Technology Bureau Project","award":["2015-2-55"],"award-info":[{"award-number":["2015-2-55"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s12035-016-9740-6","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T02:04:06Z","timestamp":1453946646000},"page":"1254-1262","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Exogenous Neural Stem Cells Transplantation as a Potential Therapy for Photothrombotic Ischemia Stroke in Kunming Mice Model"],"prefix":"10.1007","volume":"54","author":[{"given":"Boru","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junning","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"9740_CR1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuropharm.2008.05.031","volume":"55","author":"RW Flynn","year":"2008","unstructured":"Flynn RW, MacWalter RS, Doney AS (2008) The cost of cerebral ischaemia. Neuropharmacology 55:250\u2013256","journal-title":"Neuropharmacology"},{"key":"9740_CR2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbadis.2009.09.003","volume":"1802","author":"NR Sims","year":"2010","unstructured":"Sims NR, Muyderman H (2010) Mitochondria, oxidative metabolism and cell death in stroke. Biochim Biophys Acta 1802:80\u201391","journal-title":"Biochim Biophys Acta"},{"key":"9740_CR3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","volume":"67","author":"MA Moskowitz","year":"2010","unstructured":"Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron 67:181\u2013198","journal-title":"Neuron"},{"key":"9740_CR4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1479-5876-8-77","volume":"8","author":"C Sun","year":"2010","unstructured":"Sun C, Zhang H, Li J et al (2010) Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. J Transl Med 8:77","journal-title":"J Transl Med"},{"key":"9740_CR5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.neuropharm.2008.01.005","volume":"55","author":"KP Doyle","year":"2008","unstructured":"Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55:310\u2013318","journal-title":"Neuropharmacology"},{"key":"9740_CR6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1747-4949.2008.00187.x","volume":"3","author":"CL Allen","year":"2008","unstructured":"Allen CL, Bayraktutan U (2008) Risk factors for ischaemic stroke. Int J Stroke 3:105\u2013116","journal-title":"Int J Stroke"},{"key":"9740_CR7","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.STR.0000229883.72010.e4","volume":"37","author":"GJ Hankey","year":"2006","unstructured":"Hankey GJ (2006) Potential new risk factors for ischemic stroke: what is their potential? Stroke 37:2181\u20132188","journal-title":"Stroke"},{"key":"9740_CR8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/01.STR.0000116869.64771.5A","volume":"35","author":"CM Lawes","year":"2004","unstructured":"Lawes CM, Bennett DA, Feigin VL, Rodgers A (2004) Blood pressure and stroke: an overview of published reviews. Stroke 35:1024","journal-title":"Stroke"},{"key":"9740_CR9","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.2337\/diacare.27.12.2836","volume":"27","author":"CM Lawes","year":"2004","unstructured":"Lawes CM, Parag V, Bennett DA et al (2004) Blood glucose and risk of cardiovascular disease in the Asia Pacific region. Diabetes Care 27:2836\u20132842","journal-title":"Diabetes Care"},{"key":"9740_CR10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa061894","volume":"355","author":"P Amarenco","year":"2006","unstructured":"Amarenco P, Bogousslavsky J, Callahan A 3rd et al (2006) High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 355:549\u2013559","journal-title":"N Engl J Med"},{"key":"9740_CR11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/tc.8.2.156","volume":"8","author":"R Bonita","year":"1999","unstructured":"Bonita R, Duncan J, Truelsen T, Jackson RT, Beaglehole R (1999) Passive smoking as well as active smoking increases the risk of acute stroke. Tob Control 8:156\u2013160","journal-title":"Tob Control"},{"key":"9740_CR12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","volume":"346","author":"SA Bernard","year":"2002","unstructured":"Bernard SA, Gray TW, Buist MD et al (2002) Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346:557\u2013563","journal-title":"N Engl J Med"},{"key":"9740_CR13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1179\/016164105X25261","volume":"27","author":"KR Wagner","year":"2005","unstructured":"Wagner KR, Zuccarello M (2005) Local brain hypothermia for neuroprotection in stroke treatment and aneurysm repair. Neurol Res 27:238\u2013245","journal-title":"Neurol Res"},{"key":"9740_CR14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0165-0173(99)00013-2","volume":"30","author":"I Semkova","year":"1999","unstructured":"Semkova I, Krieglstein J (1999) Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors. Brain Res Brain Res Rev 30:176\u2013188","journal-title":"Brain Res Brain Res Rev"},{"key":"9740_CR15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3171\/2009.2.JNS081199","volume":"111","author":"L Fletcher","year":"2009","unstructured":"Fletcher L, Kohli S, Sprague SM et al (2009) Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation. J Neurosurg 111:164\u2013170","journal-title":"J Neurosurg"},{"key":"9740_CR16","doi-asserted-by":"crossref","first-page":"0491","DOI":"10.1016\/S1474-4422(09)70061-4","volume":"8","author":"ZG Zhang","year":"2009","unstructured":"Zhang ZG, Chopp M (2009) Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol 8:0491\u20130500","journal-title":"Lancet Neurol"},{"key":"9740_CR17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1474-4422(09)70202-9","volume":"8","author":"P Koch","year":"2009","unstructured":"Koch P, Kokaia Z, Lindvall O, Brustle O (2009) Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling. Lancet Neurol 8:819\u2013829","journal-title":"Lancet Neurol"},{"key":"9740_CR18","doi-asserted-by":"crossref","unstructured":"Deacon RM (2013) Measuring the strength of mice. J Vis Exp","DOI":"10.3791\/2610"},{"key":"9740_CR19","doi-asserted-by":"crossref","unstructured":"Labat-gest V, Tomasi S (2013) Photothrombotic ischemia: a minimally invasive and reproducible photochemical cortical lesion model for mouse stroke studies. J Vis Exp","DOI":"10.3791\/50370"},{"key":"9740_CR20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1089\/hum.2006.17.693","volume":"17","author":"DJ Watson","year":"2006","unstructured":"Watson DJ, Walton RM, Magnitsky SG et al (2006) Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Hum Gene Ther 17:693\u2013704","journal-title":"Hum Gene Ther"},{"key":"9740_CR21","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJMra043666","volume":"353","author":"N Sanai","year":"2005","unstructured":"Sanai N, Alvarez-Buylla A, Berger MS (2005) Neural stem cells and the origin of gliomas. N Engl J Med 353:811\u2013822","journal-title":"N Engl J Med"},{"key":"9740_CR22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1517\/14728222.2013.766170","volume":"17","author":"R Karki","year":"2013","unstructured":"Karki R, Mariani M, Andreoli M et al (2013) betaIII-Tubulin: biomarker of taxane resistance or drug target? Expert Opin Ther Targets 17:461\u2013472","journal-title":"Expert Opin Ther Targets"},{"key":"9740_CR23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0022-510X(78)90107-7","volume":"35","author":"CM Jacque","year":"1978","unstructured":"Jacque CM, Vinner C, Kujas M et al (1978) Determination of glial fibrillary acidic protein (GFAP) in human brain tumors. J Neurol Sci 35:147\u2013155","journal-title":"J Neurol Sci"},{"key":"9740_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(80)91090-2","volume":"200","author":"U Roessmann","year":"1980","unstructured":"Roessmann U, Velasco ME, Sindely SD, Gambetti P (1980) Glial fibrillary acidic protein (GFAP) in ependymal cells during development. An immunocytochemical study. Brain Res 200:13\u201321","journal-title":"Brain Res"},{"key":"9740_CR25","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","volume":"8","author":"A Arvidsson","year":"2002","unstructured":"Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O (2002) Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8:963\u2013970","journal-title":"Nat Med"},{"key":"9740_CR26","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ana.10393","volume":"52","author":"JM Parent","year":"2002","unstructured":"Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM (2002) Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 52:802\u2013813","journal-title":"Ann Neurol"},{"issue":"8","key":"9740_CR27","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/jcbfm.2010.66","volume":"30","author":"DW Howells","year":"2010","unstructured":"Howells DW, Porritt MJ, Rewell SS, O\u2019Collins V, Sena ES, van der Worp HB, Traystman RJ, Macleod MR (2010) Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia. J Cereb Blood Flow Metab 30(8):1412\u20131431","journal-title":"J Cereb Blood Flow Metab"},{"key":"9740_CR28","first-page":"3445","volume":"9","author":"F Fluri","year":"2015","unstructured":"Fluri F, Schuhmann MK, Kleinschnitz C (2015) Animal models of ischemic stroke and their application in clinical research. Drug Des Devel Ther 9:3445\u20133454","journal-title":"Drug Des Devel Ther"},{"issue":"4","key":"9740_CR29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/archneur.65.4.452","volume":"65","author":"O Einstein","year":"2008","unstructured":"Einstein O, Ben-Hur T (2008) The changing face of neural stem cell therapy in neurologic diseases. Arch Neurol 65(4):452\u2013456","journal-title":"Arch Neurol"},{"key":"9740_CR30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nbd.2014.05.014","volume":"69","author":"C Vandeputte","year":"2014","unstructured":"Vandeputte C, Reumers V, Aelvoet SA et al (2014) Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiol Dis 69:144\u2013155","journal-title":"Neurobiol Dis"},{"issue":"1","key":"9740_CR31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.scr.2008.06.002","volume":"2","author":"E Akesson","year":"2009","unstructured":"Akesson E, Wolmer-Solberg N, Cederarv M, Falci S, Odeberg J (2009) Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte response. Stem Cell Res 2(1):56\u201367","journal-title":"Stem Cell Res"},{"key":"9740_CR32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12975-011-0100-6","volume":"2","author":"Z Kokaia","year":"2011","unstructured":"Kokaia Z, Darsalia V (2011) Neural stem cell-based therapy for ischemic stroke. Transl Stroke Res 2:272\u2013278","journal-title":"Transl Stroke Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9740-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-9740-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9740-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9740-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:48:12Z","timestamp":1559429292000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-9740-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,28]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["9740"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-9740-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,28]]}}}