{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:46:11Z","timestamp":1792179971406,"version":"4.4.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Guangdong Province National Natural Science Foundation","award":["2014A030308016"],"award-info":[{"award-number":["2014A030308016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s12035-016-9793-6","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T07:43:15Z","timestamp":1456299795000},"page":"2012-2021","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["The Role of Long Noncoding RNAs in Neurodegenerative Diseases"],"prefix":"10.1007","volume":"54","author":[{"given":"Peixing","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenru","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"9793_CR1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1055\/s-0033-1360316","volume":"231","author":"KEC Gobel","year":"2014","unstructured":"Gobel KEC (2014) Neurological disorders and glaucoma - an overview. Klin Monbl Augenheilkd 231:130\u20135","journal-title":"Klin Monbl Augenheilkd"},{"issue":"52","key":"9793_CR2","doi-asserted-by":"crossref","first-page":"45093","DOI":"10.1074\/jbc.M111.310250","volume":"286","author":"M Airavaara","year":"2011","unstructured":"Airavaara M, Pletnikova O, Doyle ME et al (2011) Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem 286(52):45093\u2013102","journal-title":"J Biol Chem"},{"issue":"7443","key":"9793_CR3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nj7443-127a","volume":"496","author":"A Maxmen","year":"2013","unstructured":"Maxmen A (2013) RNA: the genome's rising stars. Nature 496(7443):127\u20139","journal-title":"Nature"},{"issue":"7291","key":"9793_CR4","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","volume":"464","author":"RA Gupta","year":"2010","unstructured":"Gupta RA, Shah N, Wang KC et al (2010) Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464(7291):1071\u20136","journal-title":"Nature"},{"key":"9793_CR5","doi-asserted-by":"crossref","unstructured":"Ma Y, Yang Y, Wang F, et al. Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt\/\u03b2-catenin signalling pathway via suppression of activator protein 2\u03b1. Gut, 2015","DOI":"10.1136\/gutjnl-2014-308392"},{"issue":"10","key":"9793_CR6","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/STROKEAHA.112.669465","volume":"43","author":"A Dharap","year":"2012","unstructured":"Dharap A, Nakka VP, Vemuganti R (2012) Effect of focal ischemia on long noncoding RNAs. Stroke 43(10):2800\u20132","journal-title":"Stroke"},{"key":"9793_CR7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fneur.2015.00050","volume":"6","author":"JA Saugstad","year":"2015","unstructured":"Saugstad JA (2015) Non-Coding RNAs in Stroke and Neuroprotection. Front Neurol 6:50","journal-title":"Front Neurol"},{"issue":"4","key":"9793_CR8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbrc.2015.04.149","volume":"462","author":"DY Lee","year":"2015","unstructured":"Lee DY, Moon J, Lee ST et al (2015) Dysregulation of long non-coding RNAs in mouse models of localization-related epilepsy. Biochem Biophys Res Commun 462(4):433\u201340","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"9793_CR9","first-page":"3979","volume":"8","author":"Y Luo","year":"2015","unstructured":"Luo Y, Li S, Teng Y et al (2015) Differential expression of FOXA1, DUSP6, and HA117 in colon segments of Hirschsprung's disease. Int J Clin Exp Pathol 8(4):3979\u201386","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"9793_CR10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/gr.4200206","volume":"16","author":"T Ravasi","year":"2006","unstructured":"Ravasi T, Suzuki H, Pang KC et al (2006) Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res 16(1):11\u20139","journal-title":"Genome Res"},{"issue":"2","key":"9793_CR11","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1073\/pnas.0706729105","volume":"105","author":"TR Mercer","year":"2008","unstructured":"Mercer TR, Dinger ME, Sunkin SM et al (2008) Specific expression of long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A 105(2):716\u201321","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6304","key":"9793_CR12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/349038a0","volume":"349","author":"CJ Brown","year":"1991","unstructured":"Brown CJ, Ballabio A, Rupert JL et al (1991) A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349(6304):38\u201344","journal-title":"Nature"},{"issue":"6322","key":"9793_CR13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/351153a0","volume":"351","author":"MS Bartolomei","year":"1991","unstructured":"Bartolomei MS, Zemel S, Tilghman SM (1991) Parental imprinting of the mouse H19 gene. Nature 351(6322):153\u20135","journal-title":"Nature"},{"issue":"5830","key":"9793_CR14","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.1138341","volume":"316","author":"PCJ Kapranov","year":"2007","unstructured":"Kapranov PCJ, Dike S (2007) ea. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316(5830):1484\u20138","journal-title":"Science"},{"issue":"2","key":"9793_CR15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1479-7364-5-2-90","volume":"5","author":"MW Wright","year":"2011","unstructured":"Wright MW, Bruford EA (2011) Naming 'junk': human non-protein coding RNA (ncRNA) gene nomenclature. Hum Genomics 5(2):90\u20138","journal-title":"Hum Genomics"},{"issue":"pt15","key":"9793_CR16","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1242\/jcs.009357","volume":"120","author":"MHT Sone","year":"2007","unstructured":"Sone MHT, Tarui H (2007) ea. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. J Cell Sci 120(pt15):2498\u2013506","journal-title":"J Cell Sci"},{"issue":"11","key":"9793_CR17","doi-asserted-by":"crossref","first-page":"e1000176","DOI":"10.1371\/journal.pcbi.1000176","volume":"4","author":"ME Dinger","year":"2008","unstructured":"Dinger ME, Pang KC, Mercer TR et al (2008) Differentiating protein-coding and noncoding RNA: challenges and ambiguities. PLoS Comput Biol 4(11):e1000176","journal-title":"PLoS Comput Biol"},{"issue":"4","key":"9793_CR18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1101\/gr.3155905","volume":"15","author":"H Kiyosawa","year":"2005","unstructured":"Kiyosawa H, Mise N, Iwase S et al (2005) Disclosing hidden transcripts: mouse natural sense-antisense transcripts tend to be poly(A) negative and nuclear localized. Genome Res 15(4):463\u201374","journal-title":"Genome Res"},{"issue":"9","key":"9793_CR19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","volume":"22","author":"T Derrien","year":"2012","unstructured":"Derrien T, Johnson R, Bussotti G et al (2012) The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 22(9):1775\u201389","journal-title":"Genome Res"},{"issue":"9","key":"9793_CR20","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1101\/gr.134767.111","volume":"22","author":"B B\u00e1nfai","year":"2012","unstructured":"B\u00e1nfai B, Jia H, Khatun J et al (2012) Long noncoding RNAs are rarely translated in two human cell lines. Genome Res 22(9):1646\u201357","journal-title":"Genome Res"},{"issue":"5","key":"9793_CR21","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1371\/journal.pbio.0050106","volume":"5","author":"MI Galindo","year":"2007","unstructured":"Galindo MI, Pueyo JI, Fouix S et al (2007) Peptides encoded by short ORFs control development and define a new eukaryotic gene family. PLoS Biol 5(5):e106","journal-title":"PLoS Biol"},{"issue":"5","key":"9793_CR22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tig.2015.03.007","volume":"31","author":"LG St","year":"2015","unstructured":"St LG, Wahlestedt C, Kapranov P (2015) The Landscape of long noncoding RNA classification. Trends Genet 31(5):239\u201351","journal-title":"Trends Genet"},{"issue":"9","key":"9793_CR23","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","volume":"22","author":"J Harrow","year":"2012","unstructured":"Harrow J, Frankish A, Gonzalez JM et al (2012) GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res 22(9):1760\u201374","journal-title":"Genome Res"},{"key":"9793_CR24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainresbull.2013.06.001","volume":"97","author":"P Wu","year":"2013","unstructured":"Wu P, Zuo X, Deng H et al (2013) Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases. Brain Res Bull 97:69\u201380","journal-title":"Brain Res Bull"},{"issue":"3","key":"9793_CR25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","volume":"10","author":"TR Mercer","year":"2009","unstructured":"Mercer TR, Dinger ME, Mattick JS (2009) Long non-coding RNAs: insights into functions. Nat Rev Genet 10(3):155\u20139","journal-title":"Nat Rev Genet"},{"issue":"7483","key":"9793_CR26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","volume":"505","author":"Y Tay","year":"2014","unstructured":"Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505(7483):344\u201352","journal-title":"Nature"},{"issue":"7414","key":"9793_CR27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","volume":"489","author":"S Djebali","year":"2012","unstructured":"Djebali S, Davis CA, Merkel A et al (2012) Landscape of transcription in human cells. Nature 489(7414):101\u20138","journal-title":"Nature"},{"issue":"4","key":"9793_CR28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","volume":"136","author":"CP Ponting","year":"2009","unstructured":"Ponting CP, Oliver PL, Reik W (2009) Evolution and functions of long noncoding RNAs. Cell 136(4):629\u201341","journal-title":"Cell"},{"issue":"13","key":"9793_CR29","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1101\/gad.1800909","volume":"23","author":"JE Wilusz","year":"2009","unstructured":"Wilusz JE, Sunwoo H, Spector DL (2009) Long noncoding RNAs: functional surprises from the RNA world. Genes Dev 23(13):1494\u2013504","journal-title":"Genes Dev"},{"key":"9793_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2014.04.002","volume":"762","author":"X Li","year":"2014","unstructured":"Li X, Wu Z, Fu X et al (2014) lncRNAs: insights into their function and mechanics in underlying disorders. Mutat Res Rev Mutat Res 762:1\u201321","journal-title":"Mutat Res Rev Mutat Res"},{"key":"9793_CR31","doi-asserted-by":"crossref","unstructured":"Roberts TC, Morris KV, Wood MJ. The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philos Trans R Soc Lond B Biol Sci, 2014,369(1652)","DOI":"10.1098\/rstb.2013.0507"},{"issue":"8","key":"9793_CR32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tig.2013.03.002","volume":"29","author":"SY Ng","year":"2013","unstructured":"Ng SY, Lin L, Soh BS et al (2013) Long noncoding RNAs in development and disease of the central nervous system. Trends Genet 29(8):461\u20138","journal-title":"Trends Genet"},{"key":"9793_CR33","doi-asserted-by":"crossref","first-page":"929042","DOI":"10.4061\/2011\/929042","volume":"2011","author":"F Modarresi","year":"2011","unstructured":"Modarresi F, Faghihi MA, Patel NS et al (2011) Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. Int J Alzheimers Dis 2011:929042","journal-title":"Int J Alzheimers Dis"},{"issue":"5","key":"9793_CR34","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/gb-2010-11-5-r56","volume":"11","author":"MA Faghihi","year":"2010","unstructured":"Faghihi MA, Zhang M, Huang J et al (2010) Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol 11(5):R56","journal-title":"Genome Biol"},{"issue":"5","key":"9793_CR35","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.celrep.2014.04.050","volume":"7","author":"MJ Kang","year":"2014","unstructured":"Kang MJ, Abdelmohsen K, Hutchison ER et al (2014) HuD regulates coding and noncoding RNA to induce APP\u2009\u2192\u2009A\u03b2 processing. Cell Rep 7(5):1401\u20139","journal-title":"Cell Rep"},{"issue":"7","key":"9793_CR36","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm1784","volume":"14","author":"MAMF Faghihi","year":"2008","unstructured":"Faghihi MAMF, Khalil AM et al (2008) ea. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med 14(7):723\u201330","journal-title":"Nat Med"},{"issue":"25","key":"9793_CR37","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.0701532104","volume":"104","author":"EHPR Mus","year":"2007","unstructured":"Mus EHPR, Tiedge H (2007) Dendritic BC200 RNA in aging and in Alzheimer's disease. Proc Natl Acad Sci U S A 104(25):10679\u201384","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9793_CR38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/BF00968788","volume":"17","author":"WJ Lukiw","year":"1992","unstructured":"Lukiw WJ, Handley P, Wong L et al (1992) BC200 RNA in normal human neocortex, non-Alzheimer dementia (NAD), and senile dementia of the Alzheimer type (AD). Neurochem Res 17(6):591\u20137","journal-title":"Neurochem Res"},{"issue":"3","key":"9793_CR39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S1461145710001008","volume":"14","author":"C Laske","year":"2011","unstructured":"Laske C, Stellos K, Hoffmann N et al (2011) Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. Int J Neuropsychopharmacol 14(3):399\u2013404","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"9793_CR40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3233\/JAD-2010-100264","volume":"21","author":"Y Zeng","year":"2010","unstructured":"Zeng Y, Zhao D, Xie CW (2010) Neurotrophins enhance CaMKII activity and rescue amyloid-\u03b2-induced deficits in hippocampal synaptic plasticity. J Alzheimers Dis 21(3):823\u201331","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"9793_CR41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.nbd.2010.09.019","volume":"41","author":"SVI Massone","year":"2011","unstructured":"Massone SVI, Fiorino G et al (2011) ea. 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease. Neurobiol Dis 41(2):308\u201317","journal-title":"Neurobiol Dis"},{"issue":"4","key":"9793_CR42","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3233\/JAD-2011-101881","volume":"24","author":"I Arisi","year":"2011","unstructured":"Arisi I, D'Onofrio M, Brandi R et al (2011) Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: mining of microarray data by logic classification and feature selection. J Alzheimers Dis 24(4):721\u201338","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"9793_CR43","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1111\/j.1460-9568.2007.05864.x","volume":"26","author":"R Parenti","year":"2007","unstructured":"Parenti R, Paratore S, Torrisi A et al (2007) A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during beta-amyloid-induced apoptosis. Eur J Neurosci 26(9):2444\u201357","journal-title":"Eur J Neurosci"},{"issue":"2","key":"9793_CR44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/humu.22239","volume":"34","author":"G Chen","year":"2013","unstructured":"Chen G, Qiu C, Zhang Q et al (2013) Genome-wide analysis of human SNPs at long intergenic noncoding RNAs. Hum Mutat 34(2):338\u201344","journal-title":"Hum Mutat"},{"issue":"6","key":"9793_CR45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/00207454.2014.944616","volume":"125","author":"XZJ Luo","year":"2015","unstructured":"Luo XZJ, Cheng Z et al (2015) ea. Lack of association of a genetic variant in the long intergenic noncoding RNA (linc01080) with Alzheimer's disease and amnestic mild cognitive impairment in Han Chinese. International Journal of Neuroscience 125(6):419\u2013423","journal-title":"International Journal of Neuroscience"},{"key":"9793_CR46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2014.02.006","volume":"17","author":"P Lau","year":"2014","unstructured":"Lau P, Frigerio CS, De Strooper B (2014) Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing Res Rev 17:43\u201353","journal-title":"Ageing Res Rev"},{"issue":"3","key":"9793_CR47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1101\/gr.087775.108","volume":"19","author":"H Sunwoo","year":"2009","unstructured":"Sunwoo H, Dinger ME, Wilusz JE et al (2009) MEN epsilon\/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res 19(3):347\u201359","journal-title":"Genome Res"},{"issue":"1","key":"9793_CR48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.celrep.2012.06.003","volume":"2","author":"B Zhang","year":"2012","unstructured":"Zhang B, Arun G, Mao YS et al (2012) The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Rep 2(1):111\u201323","journal-title":"Cell Rep"},{"issue":"44","key":"9793_CR49","doi-asserted-by":"crossref","first-page":"14708","DOI":"10.1523\/JNEUROSCI.1637-10.2010","volume":"30","author":"Y Xie","year":"2010","unstructured":"Xie Y, Hayden MR, Xu B (2010) BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice. J Neurosci 30(44):14708\u201318","journal-title":"J Neurosci"},{"issue":"5","key":"9793_CR50","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2158","volume":"30","author":"F Modarresi","year":"2012","unstructured":"Modarresi F, Faghihi MA, Lopez-Toledano MA et al (2012) Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol 30(5):453\u20139","journal-title":"Nat Biotechnol"},{"issue":"3","key":"9793_CR51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/physiolgenomics.00019.2010","volume":"41","author":"R Johnson","year":"2010","unstructured":"Johnson R, Richter N, Jauch R et al (2010) Human accelerated region 1 noncoding RNA is repressed by REST in Huntington's disease. Physiol Genomics 41(3):269\u201374","journal-title":"Physiol Genomics"},{"issue":"3","key":"9793_CR52","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.neurobiolaging.2014.11.014","volume":"36","author":"L Francelle","year":"2015","unstructured":"Francelle L, Galvan L, Gaillard MC et al (2015) Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo. Neurobiol Aging 36(3):1601, e7-16","journal-title":"Neurobiol Aging"},{"issue":"3","key":"9793_CR53","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1471-4159.2010.07126.x","volume":"116","author":"SK Michelhaugh","year":"2011","unstructured":"Michelhaugh SK, Lipovich L, Blythe J et al (2011) Mining Affymetrix microarray data for long non-coding RNAs: altered expression in the nucleus accumbens of heroin abusers. J Neurochem 116(3):459\u201366","journal-title":"J Neurochem"},{"issue":"7","key":"9793_CR54","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1101\/gr.103473.109","volume":"20","author":"T Mondal","year":"2010","unstructured":"Mondal T, Rasmussen M, Pandey GK et al (2010) Characterization of the RNA content of chromatin. Genome Res 20(7):899\u2013907","journal-title":"Genome Res"},{"issue":"2","key":"9793_CR55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/emmm.200900006","volume":"1","author":"VA Morais","year":"2009","unstructured":"Morais VA, Verstreken P, Roethig A et al (2009) Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med 1(2):99\u2013111","journal-title":"EMBO Mol Med"},{"key":"9793_CR56","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2164-8-74","volume":"8","author":"C Scheele","year":"2007","unstructured":"Scheele C, Petrovic N, Faghihi MA et al (2007) The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. BMC Genomics 8:74","journal-title":"BMC Genomics"},{"issue":"3","key":"9793_CR57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000251963","volume":"126","author":"M Chiba","year":"2009","unstructured":"Chiba M, Kiyosawa H, Hiraiwa N et al (2009) Existence of Pink1 antisense RNAs in mouse and their localization. Cytogenet Genome Res 126(3):259\u201370","journal-title":"Cytogenet Genome Res"},{"issue":"7424","key":"9793_CR58","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature11508","volume":"491","author":"C Carrieri","year":"2012","unstructured":"Carrieri C, Cimatti L, Biagioli M et al (2012) Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature 491(7424):454\u20137","journal-title":"Nature"},{"key":"9793_CR59","first-page":"114","volume":"9","author":"CFA Carrieri","year":"2015","unstructured":"Carrieri CFA, Santoro C et al (2015) Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells\u2019 differentiation in vitro and in neurochemical models of Parkinson\u2019s disease. Front Cell Neurosci 9:114","journal-title":"Front. Cell. Neurosci"},{"issue":"2","key":"9793_CR60","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","volume":"72","author":"AE Renton","year":"2011","unstructured":"Renton AE, Majounie E, Waite A et al (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72(2):257\u201368","journal-title":"Neuron"},{"issue":"2","key":"9793_CR61","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","volume":"72","author":"M DeJesus-Hernandez","year":"2011","unstructured":"DeJesus-Hernandez M, Mackenzie IR, Boeve BF et al (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72(2):245\u201356","journal-title":"Neuron"},{"issue":"51","key":"9793_CR62","doi-asserted-by":"crossref","first-page":"E4968","DOI":"10.1073\/pnas.1315438110","volume":"110","author":"T Zu","year":"2013","unstructured":"Zu T, Liu Y, Ba\u00f1ez-Coronel M et al (2013) RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proc Natl Acad Sci U S A 110(51):E4968\u201377","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9793_CR63","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00401-013-1200-z","volume":"126","author":"S Mizielinska","year":"2013","unstructured":"Mizielinska S, Lashley T, Norona FE et al (2013) C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci. Acta Neuropathol 126(6):845\u201357","journal-title":"Acta Neuropathol"},{"key":"9793_CR64","doi-asserted-by":"crossref","first-page":"E4530","DOI":"10.1073\/pnas.1318835110","volume":"110","author":"LTC Al","year":"2013","unstructured":"Al LTC (2013) Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci USA 110:E4530\u2013E4539","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"9793_CR65","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/hmg\/9.10.1543","volume":"9","author":"JP Nemes","year":"2000","unstructured":"Nemes JP, Benzow KA, Moseley ML et al (2000) The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Hum Mol Genet 9(10):1543\u201351","journal-title":"Hum Mol Genet"},{"key":"9793_CR66","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2008.07.096","volume":"1233","author":"WL Chen","year":"2008","unstructured":"Chen WL, Lin JW, Huang HJ et al (2008) SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology. Brain Res 1233:176\u201384","journal-title":"Brain Res"},{"issue":"8","key":"9793_CR67","doi-asserted-by":"crossref","first-page":"e1000600","DOI":"10.1371\/journal.pgen.1000600","volume":"5","author":"RS Daughters","year":"2009","unstructured":"Daughters RS, Tuttle DL, Gao W et al (2009) RNA gain-of-function in spinocerebellar ataxia type 8. PLoS Genet 5(8):e1000600","journal-title":"PLoS Genet"},{"issue":"11","key":"9793_CR68","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nsmb.2902","volume":"21","author":"JY Tan","year":"2014","unstructured":"Tan JY, Vance KW, Varela MA et al (2014) Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7. Nat Struct Mol Biol 21(11):955\u201361","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"9793_CR69","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.clineuro.2008.09.003","volume":"111","author":"RP Munhoz","year":"2009","unstructured":"Munhoz RP, Teive HA, Raskin S et al (2009) CTA\/CTG expansions at the SCA 8 locus in multiple system atrophy. Clin Neurol Neurosurg 111(2):208\u201310","journal-title":"Clin Neurol Neurosurg"},{"issue":"1","key":"9793_CR70","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12035-013-8416-8","volume":"48","author":"V Jindal","year":"2013","unstructured":"Jindal V (2013) Glaucoma: an extension of various chronic neurodegenerative disorders. Mol Neurobiol 48(1):186\u20139","journal-title":"Mol Neurobiol"},{"issue":"Suppl 1","key":"9793_CR71","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1097\/WNO.0000000000000293","volume":"35","author":"HV Danesh-Meyer","year":"2015","unstructured":"Danesh-Meyer HV, Levin LA (2015) Glaucoma as a neurodegenerative disease. J Neuroophthalmol 35(Suppl 1):S22\u20138","journal-title":"J Neuroophthalmol"},{"issue":"2","key":"9793_CR72","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ajo.2012.07.023","volume":"155","author":"LR Pasquale","year":"2013","unstructured":"Pasquale LR, Loomis SJ, Kang JH et al (2013) CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol 155(2):342\u2013353.e5","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"9793_CR73","doi-asserted-by":"crossref","first-page":"e33389","DOI":"10.1371\/journal.pone.0033389","volume":"7","author":"M Nakano","year":"2012","unstructured":"Nakano M, Ikeda Y, Tokuda Y et al (2012) Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PLoS One 7(3):e33389","journal-title":"PLoS One"},{"issue":"22","key":"9793_CR74","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1093\/hmg\/ddv347","volume":"24","author":"MA Hauser","year":"2015","unstructured":"Hauser MA, Aboobakar IF, Liu Y et al (2015) Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus. Hum Mol Genet 24(22):6552\u201363","journal-title":"Hum Mol Genet"},{"key":"9793_CR75","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-801105-8.00007-2","volume":"116","author":"B Guennewig","year":"2014","unstructured":"Guennewig B, Cooper AA (2014) The central role of noncoding RNA in the brain. Int Rev Neurobiol 116:153\u201394","journal-title":"Int Rev Neurobiol"},{"issue":"6","key":"9793_CR76","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4161\/rna.20482","volume":"9","author":"C Pastori","year":"2012","unstructured":"Pastori C, Wahlestedt C (2012) Involvement of long noncoding RNAs in diseases affecting the central nervous system. RNA Biol 9(6):860\u201370","journal-title":"RNA Biol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-9793-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9793-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9793-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9793-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T13:58:07Z","timestamp":1748786287000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-9793-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,24]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9793"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-9793-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,24]]}}}