{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:38:33Z","timestamp":1771501113737,"version":"3.50.1"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2010_BN_MXM_006"],"award-info":[{"award-number":["2010_BN_MXM_006"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2012_WBSSY4_006"],"award-info":[{"award-number":["2012_WBSSY4_006"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009886","name":"Apulia Region","doi-asserted-by":"crossref","award":["FIR 2014-2015"],"award-info":[{"award-number":["FIR 2014-2015"]}],"id":[{"id":"10.13039\/501100009886","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009886","name":"Apulia Region","doi-asserted-by":"crossref","award":["FIR 2014-2015"],"award-info":[{"award-number":["FIR 2014-2015"]}],"id":[{"id":"10.13039\/501100009886","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Recent evidence pointed out that the prevalence of depression has reached epidemic proportions in last decades. This increase has been linked to many environmental factors, among these the influence of dietary factors has gained great attention. In particular, it has been reported that low n-3 polyunsaturated fatty acid (n-3 PUFA) intake in diet is correlated to the development of depressive and anxiety-like symptoms. Furthermore, maternal malnutrition is a widely accepted risk factor for developing mental illness in later adulthood; among others, depression has been strongly associated to this event. On the other hand, we have previously found that acute intracerebral injection of the soluble beta amyloid 1\u201342 (A\u03b2<jats:sub>1\u201342<\/jats:sub>) peptide induces a depressive-like behavior in rats, associated to altered hypothalamic\u2013pituitary-adrenal (HPA) axis activation and reduced cortical serotonin and neurotrophin levels. The aim of the present work was to study the effect of pre- and post-natal (5\u00a0weeks post-weaning) exposure to diets differently enriched in n-3, n-6, as well as n-6\/n-3 PUFA balanced, on immobility time displayed on the forced swimming test (FST), along with neuroendocrine quantification in offspring rats. Results showed that n-6 PUFA-enriched diet increased depressive- and anxiety-like behaviors, as shown by the elevation in the immobility time in the FST test and self-grooming in the open field test. Those effects were accompanied by reduced cortical serotonin, high plasmatic corticosterone and hypothalamic corticotropin-releasing factor levels. Finally, enhanced plasmatic A\u03b2<jats:sub>1\u201342<\/jats:sub> levels after n-6 PUFA diet and reduced plasmatic A\u03b2<jats:sub>1\u201342<\/jats:sub> levels after n-3 PUFA were found. Taken together, our data indicate that A\u03b2<jats:sub>1\u201342<\/jats:sub> might be crucially involved in behavioral alterations found after n-6 rich PUFA diet and strongly endorse the protective role of n-3 and the detrimental effect of improper n-6 PUFA diet consumption.<\/jats:p>","DOI":"10.1007\/s12035-016-9809-2","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T07:43:29Z","timestamp":1456731809000},"page":"2079-2089","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Lifelong Nutritional Omega-3 Deficiency Evokes Depressive-Like State Through Soluble Beta Amyloid"],"prefix":"10.1007","volume":"54","author":[{"given":"Maria Grazia","family":"Morgese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Mhillaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Schiavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Trabace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"9809_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000327785","volume":"102","author":"AP Simopoulos","year":"2011","unstructured":"Simopoulos AP (2011) Importance of the omega-6\/omega-3 balance in health and disease: evolutionary aspects of diet. World Rev Nutr Diet 102:10\u201321. doi:10.1159\/000327785","journal-title":"World Rev Nutr Diet"},{"key":"9809_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000192755","volume":"99","author":"AP Simopoulos","year":"2009","unstructured":"Simopoulos AP (2009) Omega-6\/omega-3 essential fatty acids: biological effects. World Rev Nutr Diet 99:1\u201316. doi:10.1159\/000192755","journal-title":"World Rev Nutr Diet"},{"key":"9809_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000235706","volume":"100","author":"AP Simopoulos","year":"2009","unstructured":"Simopoulos AP (2009) Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. World Rev Nutr Diet 100:1\u201321. doi:10.1159\/000235706","journal-title":"World Rev Nutr Diet"},{"issue":"6 Suppl","key":"9809_CR4","doi-asserted-by":"crossref","first-page":"1467S","DOI":"10.1093\/ajcn\/83.6.1467S","volume":"83","author":"LM Arterburn","year":"2006","unstructured":"Arterburn LM, Hall EB, Oken H (2006) Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 83(6 Suppl):1467S\u20131476S","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"9809_CR5","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0301-0082(95)00016-O","volume":"46","author":"H Katsuki","year":"1995","unstructured":"Katsuki H, Okuda S (1995) Arachidonic acid as a neurotoxic and neurotrophic substance. Prog Neurobiol 46(6):607\u2013636","journal-title":"Prog Neurobiol"},{"key":"9809_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0079-6123(08)63215-X","volume":"118","author":"NG Bazan","year":"1998","unstructured":"Bazan NG (1998) The neuromessenger platelet-activating factor in plasticity and neurodegeneration. Prog Brain Res 118:281\u2013291","journal-title":"Prog Brain Res"},{"issue":"6244","key":"9809_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/341739a0","volume":"341","author":"JH Williams","year":"1989","unstructured":"Williams JH, Errington ML, Lynch MA, Bliss TV (1989) Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus. Nature 341(6244):739\u2013742. doi:10.1038\/341739a0","journal-title":"Nature"},{"issue":"6486","key":"9809_CR8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/370216a0","volume":"370","author":"M Hattori","year":"1994","unstructured":"Hattori M, Adachi H, Tsujimoto M, Arai H, Inoue K (1994) Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. Nature 370(6486):216\u2013218. doi:10.1038\/370216a0","journal-title":"Nature"},{"issue":"4","key":"9809_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/mnfr.200900201","volume":"54","author":"SC Heinrichs","year":"2010","unstructured":"Heinrichs SC (2010) Dietary omega-3 fatty acid supplementation for optimizing neuronal structure and function. Mol Nutr Food Res 54(4):447\u2013456. doi:10.1002\/mnfr.200900201","journal-title":"Mol Nutr Food Res"},{"issue":"6","key":"9809_CR10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1051\/rnd:2004063","volume":"44","author":"JM Alessandri","year":"2004","unstructured":"Alessandri JM, Guesnet P, Vancassel S, Astorg P, Denis I, Langelier B, Aid S, Poumes-Ballihaut C et al (2004) Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. Reprod Nutr Dev 44(6):509\u2013538","journal-title":"Reprod Nutr Dev"},{"issue":"2","key":"9809_CR11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ajcn\/82.2.281","volume":"82","author":"JC McCann","year":"2005","unstructured":"McCann JC, Ames BN (2005) Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 82(2):281\u2013295","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"9809_CR12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nn.2736","volume":"14","author":"M Lafourcade","year":"2011","unstructured":"Lafourcade M, Larrieu T, Mato S, Duffaud A, Sepers M, Matias I, De Smedt-Peyrusse V, Labrousse VF et al (2011) Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci 14(3):345\u2013350. doi:10.1038\/nn.2736","journal-title":"Nat Neurosci"},{"key":"9809_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2015.04.008","author":"EL Sullivan","year":"2015","unstructured":"Sullivan EL, Riper KM, Lockard R, Valleau JC (2015) Maternal high-fat diet programming of the neuroendocrine system and behavior. Horm Behav. doi:10.1016\/j.yhbeh.2015.04.008","journal-title":"Horm Behav"},{"issue":"3","key":"9809_CR14","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1159\/000430229","volume":"37","author":"UE Lang","year":"2015","unstructured":"Lang UE, Beglinger C, Schweinfurth N, Walter M, Borgwardt S (2015) Nutritional aspects of depression. Cell Physiol Biochem 37(3):1029\u20131043. doi:10.1159\/000430229","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"9809_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/07315724.2010.10719836","volume":"29","author":"M Lucas","year":"2010","unstructured":"Lucas M, Kirmayer LJ, Dery S, Dewailly E (2010) Erythrocyte n-3 is inversely correlated with serious psychological distress among the Inuit: data from the Nunavik health survey. J Am Coll Nutr 29(3):211\u2013221","journal-title":"J Am Coll Nutr"},{"issue":"5\u20136","key":"9809_CR16","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.plefa.2009.10.004","volume":"81","author":"BM Ross","year":"2009","unstructured":"Ross BM (2009) Omega-3 polyunsaturated fatty acids and anxiety disorders. Prostaglandins Leukot Essent Fat Acids 81(5\u20136):309\u2013312. doi:10.1016\/j.plefa.2009.10.004","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"issue":"4","key":"9809_CR17","doi-asserted-by":"publisher","first-page":"450","DOI":"10.2174\/1871527311312040003","volume":"12","author":"B Levant","year":"2013","unstructured":"Levant B (2013) N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence. CNS Neurol Disord Drug Targets 12(4):450\u2013459","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"8","key":"9809_CR18","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.jnutbio.2011.04.018","volume":"23","author":"Y Park","year":"2012","unstructured":"Park Y, Moon HJ, Kim SH (2012) N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test. J Nutr Biochem 23(8):924\u2013928. doi:10.1016\/j.jnutbio.2011.04.018","journal-title":"J Nutr Biochem"},{"issue":"7","key":"9809_CR19","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.4088\/JCP.v68n0712","volume":"68","author":"PY Lin","year":"2007","unstructured":"Lin PY, Su KP (2007) A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry 68(7):1056\u20131061","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"9809_CR20","doi-asserted-by":"publisher","first-page":"e96905","DOI":"10.1371\/journal.pone.0096905","volume":"9","author":"G Grosso","year":"2014","unstructured":"Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F (2014) Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One 9(5):e96905. doi:10.1371\/journal.pone.0096905","journal-title":"PLoS One"},{"issue":"5","key":"9809_CR21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1177\/0269881115581093","volume":"29","author":"A Cleare","year":"2015","unstructured":"Cleare A, Pariante CM, Young AH, Anderson IM, Christmas D, Cowen PJ, Dickens C, Ferrier IN et al (2015) Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol 29(5):459\u2013525. doi:10.1177\/0269881115581093","journal-title":"J Psychopharmacol"},{"issue":"8","key":"9809_CR22","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/j.1476-5381.2010.00669.x","volume":"159","author":"M Colaianna","year":"2010","unstructured":"Colaianna M, Tucci P, Zotti M, Morgese MG, Schiavone S, Govoni S, Cuomo V, Trabace L (2010) Soluble beta amyloid(1\u201342): a critical player in producing behavioural and biochemical changes evoking depressive-related state? Br J Pharmacol 159(8):1704\u20131715","journal-title":"Br J Pharmacol"},{"issue":"4","key":"9809_CR23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/j.1476-5381.2010.00948.x","volume":"161","author":"N Pomara","year":"2010","unstructured":"Pomara N, Sidtis JJ (2010) Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targets. Br J Pharmacol 161(4):768\u2013770","journal-title":"Br J Pharmacol"},{"issue":"5","key":"9809_CR24","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1001\/archpsyc.65.5.542","volume":"65","author":"X Sun","year":"2008","unstructured":"Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Rosenberg I, Mwamburi DM et al (2008) Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry 65(5):542\u2013550","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"9809_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neuropharm.2011.07.014","volume":"62","author":"BS McEwen","year":"2012","unstructured":"McEwen BS, Eiland L, Hunter RG, Miller MM (2012) Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 62(1):3\u201312. doi:10.1016\/j.neuropharm.2011.07.014","journal-title":"Neuropharmacology"},{"issue":"5","key":"9809_CR26","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s11745-010-3523-z","volume":"46","author":"A Harauma","year":"2011","unstructured":"Harauma A, Moriguchi T (2011) Dietary n-3 fatty acid deficiency in mice enhances anxiety induced by chronic mild stress. Lipids 46(5):409\u2013416. doi:10.1007\/s11745-010-3523-z","journal-title":"Lipids"},{"issue":"10","key":"9809_CR27","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0022-2275(20)32220-3","volume":"42","author":"A Ikemoto","year":"2001","unstructured":"Ikemoto A, Ohishi M, Sato Y, Hata N, Misawa Y, Fujii Y, Okuyama H (2001) Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. J Lipid Res 42(10):1655\u20131663","journal-title":"J Lipid Res"},{"issue":"4\u20135","key":"9809_CR28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.plefa.2006.07.006","volume":"75","author":"I Fedorova","year":"2006","unstructured":"Fedorova I, Salem N Jr (2006) Omega-3 fatty acids and rodent behavior. Prostaglandins Leukot Essent Fat Acids 75(4\u20135):271\u2013289. doi:10.1016\/j.plefa.2006.07.006","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"issue":"1","key":"9809_CR29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5498\/wjp.v5.i1.15","volume":"5","author":"RK McNamara","year":"2015","unstructured":"McNamara RK, Vannest JJ, Valentine CJ (2015) Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: mechanisms and implications for psychopathology. World J Psychiatry 5(1):15\u201334. doi:10.5498\/wjp.v5.i1.15","journal-title":"World J Psychiatry"},{"issue":"8","key":"9809_CR30","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1194\/jlr.M300079-JLR200","volume":"44","author":"S Aid","year":"2003","unstructured":"Aid S, Vancassel S, Poumes-Ballihaut C, Chalon S, Guesnet P, Lavialle M (2003) Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. J Lipid Res 44(8):1545\u20131551. doi:10.1194\/jlr.M300079-JLR200","journal-title":"J Lipid Res"},{"issue":"2","key":"9809_CR31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.biopsych.2006.03.021","volume":"61","author":"LM Monteggia","year":"2007","unstructured":"Monteggia LM, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S, Parada LF, Nestler EJ (2007) Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry 61(2):187\u2013197","journal-title":"Biol Psychiatry"},{"issue":"3","key":"9809_CR32","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0149-7634(01)00011-2","volume":"25","author":"E Choleris","year":"2001","unstructured":"Choleris E, Thomas AW, Kavaliers M, Prato FS (2001) A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci Biobehav Rev 25(3):235\u2013260","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"9809_CR33","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229(2):327\u2013336","journal-title":"Arch Int Pharmacodyn Ther"},{"issue":"4\u20135","key":"9809_CR34","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","volume":"29","author":"JF Cryan","year":"2005","unstructured":"Cryan JF, Valentino RJ, Lucki I (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29(4\u20135):547\u2013569","journal-title":"Neurosci Biobehav Rev"},{"key":"9809_CR35","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bbi.2014.03.021","volume":"41","author":"C Madore","year":"2014","unstructured":"Madore C, Nadjar A, Delpech JC, Sere A, Aubert A, Portal C, Joffre C, Laye S (2014) Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes. Brain Behav Immun 41:22\u201331. doi:10.1016\/j.bbi.2014.03.021","journal-title":"Brain Behav Immun"},{"issue":"1\u20133","key":"9809_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","volume":"463","author":"L Prut","year":"2003","unstructured":"Prut L, Belzung C (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463(1\u20133):3\u201333","journal-title":"Eur J Pharmacol"},{"issue":"Suppl","key":"9809_CR37","doi-asserted-by":"publisher","first-page":"S157","DOI":"10.1007\/BF02637069","volume":"31","author":"PB Adams","year":"1996","unstructured":"Adams PB, Lawson S, Sanigorski A, Sinclair AJ (1996) Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 31(Suppl):S157\u2013161","journal-title":"Lipids"},{"issue":"2","key":"9809_CR38","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.euroneuro.2005.07.005","volume":"16","author":"P Green","year":"2006","unstructured":"Green P, Hermesh H, Monselise A, Marom S, Presburger G, Weizman A (2006) Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder. Eur Neuropsychopharmacol 16(2):107\u2013113. doi:10.1016\/j.euroneuro.2005.07.005","journal-title":"Eur Neuropsychopharmacol"},{"key":"9809_CR39","doi-asserted-by":"publisher","first-page":"e437","DOI":"10.1038\/tp.2014.77","volume":"4","author":"T Larrieu","year":"2014","unstructured":"Larrieu T, Hilal ML, Fourrier C, De Smedt-Peyrusse V, Sans N, Capuron L, Laye S (2014) Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion. Transl Psychiatry 4:e437. doi:10.1038\/tp.2014.77","journal-title":"Transl Psychiatry"},{"issue":"3","key":"9809_CR40","doi-asserted-by":"publisher","first-page":"437","DOI":"10.4161\/epi.27558","volume":"9","author":"GJ Boersma","year":"2014","unstructured":"Boersma GJ, Lee RS, Cordner ZA, Ewald ER, Purcell RH, Moghadam AA, Tamashiro KL (2014) Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats. Epigenetics 9(3):437\u2013447. doi:10.4161\/epi.27558","journal-title":"Epigenetics"},{"issue":"1","key":"9809_CR41","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0006-8993(98)01010-5","volume":"813","author":"MJ Schaaf","year":"1998","unstructured":"Schaaf MJ, de Jong J, de Kloet ER, Vreugdenhil E (1998) Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res 813(1):112\u2013120","journal-title":"Brain Res"},{"issue":"3","key":"9809_CR42","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3109\/10253890009001124","volume":"3","author":"MJ Schaaf","year":"2000","unstructured":"Schaaf MJ, De Kloet ER, Vreugdenhil E (2000) Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation. Stress 3(3):201\u2013208","journal-title":"Stress"},{"issue":"11","key":"9809_CR43","doi-asserted-by":"publisher","first-page":"e7704","DOI":"10.1371\/journal.pone.0007704","volume":"4","author":"N Sarrazin","year":"2009","unstructured":"Sarrazin N, Di Blasi F, Roullot-Lacarriere V, Rouge-Pont F, Le Roux A, Costet P, Revest JM, Piazza PV (2009) Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors. PLoS One 4(11):e7704. doi:10.1371\/journal.pone.0007704","journal-title":"PLoS One"},{"issue":"2","key":"9809_CR44","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/PSY.0b013e31820ad12b","volume":"73","author":"C Stetler","year":"2011","unstructured":"Stetler C, Miller GE (2011) Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom Med 73(2):114\u2013126. doi:10.1097\/PSY.0b013e31820ad12b","journal-title":"Psychosom Med"},{"issue":"4","key":"9809_CR45","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.biopsych.2004.11.038","volume":"57","author":"WA Carlezon Jr","year":"2005","unstructured":"Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF (2005) Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry 57(4):343\u2013350. doi:10.1016\/j.biopsych.2004.11.038","journal-title":"Biol Psychiatry"},{"issue":"1","key":"9809_CR46","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ejphar.2009.10.022","volume":"626","author":"F Caraci","year":"2010","unstructured":"Caraci F, Copani A, Nicoletti F, Drago F (2010) Depression and Alzheimer\u2019s disease: neurobiological links and common pharmacological targets. Eur J Pharmacol 626(1):64\u201371. doi:10.1016\/j.ejphar.2009.10.022","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"9809_CR47","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/jnr.1229","volume":"66","author":"A Sometani","year":"2001","unstructured":"Sometani A, Kataoka H, Nitta A, Fukumitsu H, Nomoto H, Furukawa S (2001) Transforming growth factor-beta1 enhances expression of brain-derived neurotrophic factor and its receptor, TrkB, in neurons cultured from rat cerebral cortex. J Neurosci Res 66(3):369\u2013376","journal-title":"J Neurosci Res"},{"issue":"2","key":"9809_CR48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jad.2005.07.008","volume":"88","author":"AM Myint","year":"2005","unstructured":"Myint AM, Leonard BE, Steinbusch HW, Kim YK (2005) Th1, Th2, and Th3 cytokine alterations in major depression. J Affect Disord 88(2):167\u2013173. doi:10.1016\/j.jad.2005.07.008","journal-title":"J Affect Disord"},{"issue":"10","key":"9809_CR49","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.jnutbio.2013.03.005","volume":"24","author":"V Tomasdottir","year":"2013","unstructured":"Tomasdottir V, Vikingsson A, Freysdottir J, Hardardottir I (2013) Dietary fish oil reduces the acute inflammatory response and enhances resolution of antigen-induced peritonitis. J Nutr Biochem 24(10):1758\u20131765. doi:10.1016\/j.jnutbio.2013.03.005","journal-title":"J Nutr Biochem"},{"issue":"2","key":"9809_CR50","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/jcp.10298","volume":"196","author":"M Hida","year":"2003","unstructured":"Hida M, Fujita H, Ishikura K, Omori S, Hoshiya M, Awazu M (2003) Eicosapentaenoic acid inhibits PDGF-induced mitogenesis and cyclin D1 expression via TGF-beta in mesangial cells. J Cell Physiol 196(2):293\u2013300. doi:10.1002\/jcp.10298","journal-title":"J Cell Physiol"},{"issue":"5","key":"9809_CR51","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.pnpbp.2009.11.001","volume":"34","author":"MN Hill","year":"2010","unstructured":"Hill MN, McEwen BS (2010) Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids. Prog Neuro-Psychopharmacol Biol Psychiatry 34(5):791\u2013797. doi:10.1016\/j.pnpbp.2009.11.001","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"13","key":"9809_CR52","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1038\/npp.2009.114","volume":"34","author":"MN Hill","year":"2009","unstructured":"Hill MN, McLaughlin RJ, Morrish AC, Viau V, Floresco SB, Hillard CJ, Gorzalka BB (2009) Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology 34(13):2733\u20132745. doi:10.1038\/npp.2009.114","journal-title":"Neuropsychopharmacology"},{"issue":"51","key":"9809_CR53","doi-asserted-by":"publisher","first-page":"18620","DOI":"10.1073\/pnas.0509591102","volume":"102","author":"G Gobbi","year":"2005","unstructured":"Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T, Morgese MG et al (2005) Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci U S A 102(51):18620\u201318625. doi:10.1073\/pnas.0509591102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"9809_CR54","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/nm803","volume":"9","author":"S Kathuria","year":"2003","unstructured":"Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontini A, Mor M, Tarzia G et al (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9(1):76\u201381. doi:10.1038\/nm803","journal-title":"Nat Med"},{"key":"9809_CR55","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.bbr.2012.09.053","volume":"237","author":"RJ McLaughlin","year":"2013","unstructured":"McLaughlin RJ, Hill MN, Dang SS, Wainwright SR, Galea LA, Hillard CJ, Gorzalka BB (2013) Upregulation of CB(1) receptor binding in the ventromedial prefrontal cortex promotes proactive stress-coping strategies following chronic stress exposure. Behav Brain Res 237:333\u2013337. doi:10.1016\/j.bbr.2012.09.053","journal-title":"Behav Brain Res"},{"issue":"1","key":"9809_CR56","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/BF02245592","volume":"121","author":"MJ Detke","year":"1995","unstructured":"Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 121(1):66\u201372","journal-title":"Psychopharmacology"},{"issue":"6","key":"9809_CR57","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1096\/fj.14-268342","volume":"29","author":"RP Patrick","year":"2015","unstructured":"Patrick RP, Ames BN (2015) Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB J 29(6):2207\u20132222. doi:10.1096\/fj.14-268342","journal-title":"FASEB J"},{"key":"9809_CR58","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1159\/000059774","volume":"88","author":"PC Calder","year":"2001","unstructured":"Calder PC (2001) omega 3 polyunsaturated fatty acids, inflammation and immunity. World Rev Nutr Diet 88:109\u2013116","journal-title":"World Rev Nutr Diet"},{"issue":"1 Suppl","key":"9809_CR59","doi-asserted-by":"crossref","first-page":"343S","DOI":"10.1093\/ajcn\/71.1.343s","volume":"71","author":"MJ James","year":"2000","unstructured":"James MJ, Gibson RA, Cleland LG (2000) Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71(1 Suppl):343S\u2013348S","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"9809_CR60","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1017\/S0029665113001031","volume":"72","author":"PC Calder","year":"2013","unstructured":"Calder PC (2013) n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions. Proc Nutr Soc 72(3):326\u2013336. doi:10.1017\/S0029665113001031","journal-title":"Proc Nutr Soc"},{"issue":"23","key":"9809_CR61","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.1016\/j.febslet.2011.08.033","volume":"585","author":"MB Graeber","year":"2011","unstructured":"Graeber MB, Li W, Rodriguez ML (2011) Role of microglia in CNS inflammation. FEBS Lett 585(23):3798\u20133805. doi:10.1016\/j.febslet.2011.08.033","journal-title":"FEBS Lett"},{"issue":"1","key":"9809_CR62","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.bbr.2012.02.001","volume":"230","author":"S Blazevic","year":"2012","unstructured":"Blazevic S, Colic L, Culig L, Hranilovic D (2012) Anxiety-like behavior and cognitive flexibility in adult rats perinatally exposed to increased serotonin concentrations. Behav Brain Res 230(1):175\u2013181. doi:10.1016\/j.bbr.2012.02.001","journal-title":"Behav Brain Res"},{"issue":"8","key":"9809_CR63","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1073\/pnas.1416866112","volume":"112","author":"BD Sachs","year":"2015","unstructured":"Sachs BD, Ni JR, Caron MG (2015) Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress. Proc Natl Acad Sci U S A 112(8):2557\u20132562. doi:10.1073\/pnas.1416866112","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"9809_CR64","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1471-4159.2009.06345.x","volume":"111","author":"B Haenisch","year":"2009","unstructured":"Haenisch B, Bilkei-Gorzo A, Caron MG, Bonisch H (2009) Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J Neurochem 111(2):403\u2013416. doi:10.1111\/j.1471-4159.2009.06345.x","journal-title":"J Neurochem"},{"issue":"1","key":"9809_CR65","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuint.2009.09.006","volume":"56","author":"G Mathieu","year":"2010","unstructured":"Mathieu G, Denis S, Langelier B, Denis I, Lavialle M, Vancassel S (2010) DHA enhances the noradrenaline release by SH-SY5Y cells. Neurochem Int 56(1):94\u2013100. doi:10.1016\/j.neuint.2009.09.006","journal-title":"Neurochem Int"},{"issue":"4","key":"9809_CR66","doi-asserted-by":"publisher","first-page":"342","DOI":"10.2174\/1570159X12666140828220938","volume":"12","author":"D Braun","year":"2014","unstructured":"Braun D, Madrigal JL, Feinstein DL (2014) Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications. Curr Neuropharmacol 12(4):342\u2013352. doi:10.2174\/1570159X12666140828220938","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"9809_CR67","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1471-4159.2010.06622.x","volume":"113","author":"SE Counts","year":"2010","unstructured":"Counts SE, Mufson EJ (2010) Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity. J Neurochem 113(3):649\u2013660. doi:10.1111\/j.1471-4159.2010.06622.x","journal-title":"J Neurochem"},{"issue":"1","key":"9809_CR68","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3233\/JAD-141062","volume":"44","author":"X Liu","year":"2015","unstructured":"Liu X, Ye K, Weinshenker D (2015) Norepinephrine protects against amyloid-beta toxicity via TrkB. J Alzheimers Dis 44(1):251\u2013260. doi:10.3233\/JAD-141062","journal-title":"J Alzheimers Dis"},{"issue":"13","key":"9809_CR69","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1073\/pnas.0909586107","volume":"107","author":"MT Heneka","year":"2010","unstructured":"Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J et al (2010) Locus ceruleus controls Alzheimer\u2019s disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107(13):6058\u20136063","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"9809_CR70","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3233\/JAD-130131","volume":"35","author":"E Hjorth","year":"2013","unstructured":"Hjorth E, Zhu M, Toro VC, Vedin I, Palmblad J, Cederholm T, Freund-Levi Y, Faxen-Irving G et al (2013) Omega-3 fatty acids enhance phagocytosis of Alzheimer\u2019s disease-related amyloid-beta42 by human microglia and decrease inflammatory markers. J Alzheimers Dis 35(4):697\u2013713. doi:10.3233\/JAD-130131","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"9809_CR71","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.4049\/jimmunol.0803612","volume":"182","author":"JM Sanz","year":"2009","unstructured":"Sanz JM, Chiozzi P, Idzko M, Falzoni S, Fellin S, Trabace L, Di Virgilio F (2009) Activation of microglia by amyloid \u03b2 requires P2X7 receptor expression. J Immunol 182(7):4378\u20134385","journal-title":"J Immunol"},{"issue":"1","key":"9809_CR72","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1176\/appi.ajp.162.1.175","volume":"162","author":"AJ Thomas","year":"2005","unstructured":"Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O\u2019Brien JT (2005) Increase in interleukin-1beta in late-life depression. Am J Psychiatry 162(1):175\u2013177. doi:10.1176\/appi.ajp.162.1.175","journal-title":"Am J Psychiatry"},{"issue":"15","key":"9809_CR73","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.2174\/13816128113199990502","volume":"20","author":"RS Osorio","year":"2014","unstructured":"Osorio RS, Gumb T, Pomara N (2014) Soluble amyloid-beta levels and late-life depression. Curr Pharm Des 20(15):2547\u20132554","journal-title":"Curr Pharm Des"},{"issue":"7","key":"9809_CR74","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/sj.mp.4002055","volume":"13","author":"I Goshen","year":"2008","unstructured":"Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R (2008) Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13(7):717\u2013728. doi:10.1038\/sj.mp.4002055","journal-title":"Mol Psychiatry"},{"issue":"1","key":"9809_CR75","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/ajcn\/63.1.116","volume":"63","author":"GE Caughey","year":"1996","unstructured":"Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ (1996) The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 63(1):116\u2013122","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"9809_CR76","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1194\/jlr.M300217-JLR200","volume":"44","author":"C Song","year":"2003","unstructured":"Song C, Li X, Leonard BE, Horrobin DF (2003) Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. J Lipid Res 44(10):1984\u20131991. doi:10.1194\/jlr.M300217-JLR200","journal-title":"J Lipid Res"},{"key":"9809_CR77","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.1038\/srep06777","volume":"4","author":"SM Cho","year":"2014","unstructured":"Cho SM, Kim HV, Lee S, Kim HY, Kim W, Kim TS, Kim DJ, Kim Y (2014) Correlations of amyloid-beta concentrations between CSF and plasma in acute Alzheimer mouse model. Sci Rep 4:6777. doi:10.1038\/srep06777","journal-title":"Sci Rep"},{"issue":"23","key":"9809_CR78","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1212\/WNL.0b013e318258f7c2","volume":"78","author":"Y Gu","year":"2012","unstructured":"Gu Y, Schupf N, Cosentino SA, Luchsinger JA, Scarmeas N (2012) Nutrient intake and plasma beta-amyloid. Neurology 78(23):1832\u20131840. doi:10.1212\/WNL.0b013e318258f7c2","journal-title":"Neurology"},{"issue":"15","key":"9809_CR79","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.2174\/13816128113199990500","volume":"20","author":"MG Morgese","year":"2014","unstructured":"Morgese MG, Tucci P, Colaianna M, Zotti M, Cuomo V, Schiavone S, Trabace L (2014) Modulatory activity of soluble beta amyloid on HPA axis function in rats. Curr Pharm Des 20(15):2539\u20132546","journal-title":"Curr Pharm Des"},{"issue":"9","key":"9809_CR80","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1002\/gps.1763","volume":"22","author":"N Pomara","year":"2007","unstructured":"Pomara N, Sidtis J (2007) Possible therapeutic implication of Abeta disturbances in depression. Int J Geriatr Psychiatry 22(9):931\u2013932. doi:10.1002\/gps.1763","journal-title":"Int J Geriatr Psychiatry"},{"issue":"10","key":"9809_CR81","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1097\/JGP.0b013e3180547091","volume":"15","author":"P Gudmundsson","year":"2007","unstructured":"Gudmundsson P, Skoog I, Waern M, Blennow K, Palsson S, Rosengren L, Gustafson D (2007) The relationship between cerebrospinal fluid biomarkers and depression in elderly women. Am J Geriatr Psychiatr 15(10):832\u2013838. doi:10.1097\/JGP.0b013e3180547091","journal-title":"Am J Geriatr Psychiatr"},{"issue":"1","key":"9809_CR82","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1006\/bbrc.1995.2103","volume":"213","author":"M Chen","year":"1995","unstructured":"Chen M, Inestrosa NC, Ross GS, Fernandez HL (1995) Platelets are the primary source of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 213(1):96\u2013103. doi:10.1006\/bbrc.1995.2103","journal-title":"Biochem Biophys Res Commun"},{"issue":"1\u20132","key":"9809_CR83","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jns.2005.09.002","volume":"240","author":"K Tang","year":"2006","unstructured":"Tang K, Hynan LS, Baskin F, Rosenberg RN (2006) Platelet amyloid precursor protein processing: a bio-marker for Alzheimer\u2019s disease. J Neurol Sci 240(1\u20132):53\u201358. doi:10.1016\/j.jns.2005.09.002","journal-title":"J Neurol Sci"},{"issue":"3","key":"9809_CR84","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neulet.2007.09.023","volume":"427","author":"V Giedraitis","year":"2007","unstructured":"Giedraitis V, Sundelof J, Irizarry MC, Garevik N, Hyman BT, Wahlund LO, Ingelsson M, Lannfelt L (2007) The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer\u2019s disease. Neurosci Lett 427(3):127\u2013131. doi:10.1016\/j.neulet.2007.09.023","journal-title":"Neurosci Lett"},{"issue":"10","key":"9809_CR85","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1001\/archpedi.162.10.981","volume":"162","author":"ET Liem","year":"2008","unstructured":"Liem ET, Sauer PJ, Oldehinkel AJ, Stolk RP (2008) Association between depressive symptoms in childhood and adolescence and overweight in later life: review of the recent literature. Arch Pediatr Adolesc Med 162(10):981\u2013988. doi:10.1001\/archpedi.162.10.981","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"9809_CR86","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1542\/peds.107.5.1049","volume":"107","author":"DS Pine","year":"2001","unstructured":"Pine DS, Goldstein RB, Wolk S, Weissman MM (2001) The association between childhood depression and adulthood body mass index. Pediatrics 107(5):1049\u20131056","journal-title":"Pediatrics"},{"issue":"3","key":"9809_CR87","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3233\/JAD-130719","volume":"38","author":"WB Grant","year":"2014","unstructured":"Grant WB (2014) Trends in diet and Alzheimer\u2019s disease during the nutrition transition in Japan and developing countries. J Alzheimers Dis 38(3):611\u2013620. doi:10.3233\/JAD-130719","journal-title":"J Alzheimers Dis"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-016-9809-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9809-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9809-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9809-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T20:22:14Z","timestamp":1630614134000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-016-9809-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,29]]},"references-count":87,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9809"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-9809-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,29]]},"assertion":[{"value":"9 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Procedures involving animals and their care were conducted in conformity with the institutional guidelines of the Italian Ministry of Health (D.L. 26\/2014), the Guide for the Care and Use of Mammals in Neuroscience and Behavioral Research (National Research Council 2004), the Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. All procedures involving animals were conducted in accordance to ARRIVE guidelines. Animal welfare was daily monitored through the entire period of experimental procedures. No signs of distress were evidenced, anyway all efforts were made to minimize the number of animals used and their suffering.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict Interest"}}]}}