{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:29:20Z","timestamp":1793759360364,"version":"4.6.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271310"],"award-info":[{"award-number":["81271310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571281"],"award-info":[{"award-number":["81571281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s12035-016-9845-y","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T15:33:38Z","timestamp":1458315218000},"page":"2498-2506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["miR-124 Regulates the Expression of BACE1 in the Hippocampus Under Chronic Cerebral Hypoperfusion"],"prefix":"10.1007","volume":"54","author":[{"given":"Xiaowen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongweiye","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"issue":"6","key":"9845_CR1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","volume":"64","author":"E Farkas","year":"2001","unstructured":"Farkas E, Luiten PG (2001) Cerebral microvascular pathology in aging and Alzheimer\u2019s disease. Prog Neurobiol 64(6):575\u2013611","journal-title":"Prog Neurobiol"},{"issue":"Suppl 1","key":"9845_CR2","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1007\/s00702-013-1129-3","volume":"122","author":"A Popa-Wagner","year":"2015","unstructured":"Popa-Wagner A, Buga AM, Popescu B, Muresanu D (2015) Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle. J Neural Transm 122(Suppl 1):S47\u2013S54. doi:\n10.1007\/s00702-013-1129-3","journal-title":"J Neural Transm"},{"issue":"3","key":"9845_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00702-004-0191-2","volume":"112","author":"K Plaschke","year":"2005","unstructured":"Plaschke K (2005) Aspects of ageing in chronic cerebral oligaemia. Mechanisms of degeneration and compensation in rat models. J Neural Transm 112(3):393\u2013413. doi:\n10.1007\/s00702-004-0191-2","journal-title":"J Neural Transm"},{"issue":"3","key":"9845_CR4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S1474-4422(04)00683-0","volume":"3","author":"JC Torre de la","year":"2004","unstructured":"de la Torre JC (2004) Is Alzheimer\u2019s disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol 3(3):184\u2013190. doi:\n10.1016\/S1474-4422(04)00683-0","journal-title":"Lancet Neurol"},{"issue":"28","key":"9845_CR5","doi-asserted-by":"publisher","first-page":"21099","DOI":"10.1074\/jbc.M002095200","volume":"275","author":"M Haniu","year":"2000","unstructured":"Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S et al (2000) Characterization of Alzheimer\u2019s beta -secretase protein BACE. A pepsin family member with unusual properties. J Biol Chem 275(28):21099\u201321106. doi:\n10.1074\/jbc.M002095200","journal-title":"J Biol Chem"},{"issue":"10","key":"9845_CR6","doi-asserted-by":"publisher","first-page":"3632","DOI":"10.1073\/pnas.0205689101","volume":"101","author":"R Li","year":"2004","unstructured":"Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L et al (2004) Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer\u2019s disease patients. Proc Natl Acad Sci U S A 101(10):3632\u20133637. doi:\n10.1073\/pnas.0205689101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6017","key":"9845_CR7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1126\/science.1191138","volume":"331","author":"S Djuranovic","year":"2011","unstructured":"Djuranovic S, Nahvi A, Green R (2011) A parsimonious model for gene regulation by miRNAs. Science 331(6017):550\u2013553. doi:\n10.1126\/science.1191138","journal-title":"Science"},{"issue":"2","key":"9845_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.nbd.2012.01.003","volume":"46","author":"C Delay","year":"2012","unstructured":"Delay C, Mandemakers W, Hebert SS (2012) MicroRNAs in Alzheimer\u2019s disease. Neurobiol Dis 46(2):285\u2013290. doi:\n10.1016\/j.nbd.2012.01.003","journal-title":"Neurobiol Dis"},{"issue":"45","key":"9845_CR9","doi-asserted-by":"publisher","first-page":"14919","DOI":"10.1523\/JNEUROSCI.1165-14.2014","volume":"34","author":"J Zhang","year":"2014","unstructured":"Zhang J, Hu M, Teng Z, Tang YP, Chen C (2014) Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer\u2019s disease. J Neurosci Off J Soc Neurosci 34(45):14919\u201314933. doi:\n10.1523\/JNEUROSCI.1165-14.2014","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"9","key":"9845_CR10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","volume":"12","author":"M Lagos-Quintana","year":"2002","unstructured":"Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002) Identification of tissue-specific microRNAs from mouse. Curr Biol 12(9):735\u2013739","journal-title":"Curr Biol"},{"issue":"26","key":"9845_CR11","doi-asserted-by":"publisher","first-page":"8879","DOI":"10.1523\/JNEUROSCI.0558-12.2012","volume":"32","author":"M Akerblom","year":"2012","unstructured":"Akerblom M, Sachdeva R, Barde I, Verp S, Gentner B, Trono D, Jakobsson J (2012) MicroRNA-124 is a subventricular zone neuronal fate determinant. J Neurosci Off J Soc Neurosci 32(26):8879\u20138889. doi:\n10.1523\/JNEUROSCI.0558-12.2012","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"1","key":"9845_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.toxlet.2011.11.032","volume":"209","author":"M Fang","year":"2012","unstructured":"Fang M, Wang J, Zhang X, Geng Y, Hu Z, Rudd JA, Ling S, Chen W et al (2012) The miR-124 regulates the expression of BACE1\/beta-secretase correlated with cell death in Alzheimer\u2019s disease. Toxicol Lett 209(1):94\u2013105. doi:\n10.1016\/j.toxlet.2011.11.032","journal-title":"Toxicol Lett"},{"issue":"3","key":"9845_CR13","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/WNR.0b013e3280148e8b","volume":"18","author":"WJ Lukiw","year":"2007","unstructured":"Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer\u2019s disease hippocampus. Neuroreport 18(3):297\u2013300. doi:\n10.1097\/WNR.0b013e3280148e8b","journal-title":"Neuroreport"},{"issue":"2","key":"9845_CR14","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1471-4159.2010.07097.x","volume":"116","author":"P Smith","year":"2011","unstructured":"Smith P, Al Hashimi A, Girard J, Delay C, Hebert SS (2011) In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem 116(2):240\u2013247. doi:\n10.1111\/j.1471-4159.2010.07097.x","journal-title":"J Neurochem"},{"issue":"7","key":"9845_CR15","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1161\/STROKEAHA.111.000613","volume":"44","author":"X Liu","year":"2013","unstructured":"Liu X, Li F, Zhao S, Luo Y, Kang J, Zhao H, Yan F, Li S et al (2013) MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke. Stroke; a journal of cerebral circulation 44(7):1973\u20131980. doi:\n10.1161\/STROKEAHA.111.000613","journal-title":"Stroke; a journal of cerebral circulation"},{"issue":"10","key":"9845_CR16","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/cns.12142","volume":"19","author":"Y Sun","year":"2013","unstructured":"Sun Y, Gui H, Li Q, Luo ZM, Zheng MJ, Duan JL, Liu X (2013) MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke. CNS Neurosci Ther 19(10):813\u2013819. doi:\n10.1111\/cns.12142","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"9845_CR17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2220\/biomedres.32.135","volume":"32","author":"H Weng","year":"2011","unstructured":"Weng H, Shen C, Hirokawa G, Ji X, Takahashi R, Shimada K, Kishimoto C, Iwai N (2011) Plasma miR-124 as a biomarker for cerebral infarction. Biomed Res 32(2):135\u2013141","journal-title":"Biomed Res"},{"issue":"11","key":"9845_CR18","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1373\/clinchem.2009.131797","volume":"55","author":"OF Laterza","year":"2009","unstructured":"Laterza OF, Lim L, Garrett-Engele PW, Vlasakova K, Muniappa N, Tanaka WK, Johnson JM, Sina JF et al (2009) Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem 55(11):1977\u20131983. doi:\n10.1373\/clinchem.2009.131797","journal-title":"Clin Chem"},{"issue":"1","key":"9845_CR19","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s12031-013-0155-9","volume":"52","author":"F Zhu","year":"2014","unstructured":"Zhu F, Liu JL, Li JP, Xiao F, Zhang ZX, Zhang L (2014) MicroRNA-124 (miR-124) regulates Ku70 expression and is correlated with neuronal death induced by ischemia\/reperfusion. J Mol Neurosci 52(1):148\u2013155. doi:\n10.1007\/s12031-013-0155-9","journal-title":"J Mol Neurosci"},{"issue":"4","key":"9845_CR20","doi-asserted-by":"publisher","first-page":"826 e831","DOI":"10.1016\/j.neurobiolaging.2011.05.027","volume":"33","author":"H Liu","year":"2012","unstructured":"Liu H, Xing A, Wang X, Liu G, Li L (2012) Regulation of beta-amyloid level in the brain of rats with cerebrovascular hypoperfusion. Neurobiol Aging 33(4):826 e831\u2013842. doi:\n10.1016\/j.neurobiolaging.2011.05.027","journal-title":"Neurobiol Aging"},{"issue":"3","key":"9845_CR21","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3233\/JAD-2010-100216","volume":"21","author":"X Wang","year":"2010","unstructured":"Wang X, Xing A, Xu C, Cai Q, Liu H, Li L (2010) Cerebrovascular hypoperfusion induces spatial memory impairment, synaptic changes, and amyloid-beta oligomerization in rats. J Alzheimers Dis 21(3):813\u2013822. doi:\n10.3233\/JAD-2010-100216","journal-title":"J Alzheimers Dis"},{"issue":"1-2","key":"9845_CR22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0006-8993(94)90394-8","volume":"653","author":"J Ni","year":"1994","unstructured":"Ni J, Ohta H, Matsumoto K, Watanabe H (1994) Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats. Brain Res 653(1-2):231\u2013236","journal-title":"Brain Res"},{"issue":"4","key":"9845_CR23","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.neuron.2012.02.003","volume":"73","author":"Y Yang","year":"2012","unstructured":"Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q et al (2012) EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron 73(4):774\u2013788. doi:\n10.1016\/j.neuron.2012.02.003","journal-title":"Neuron"},{"issue":"Suppl 4","key":"9845_CR24","doi-asserted-by":"publisher","first-page":"S411","DOI":"10.3233\/JAD-141467","volume":"42","author":"CE Wierenga","year":"2014","unstructured":"Wierenga CE, Hays CC, Zlatar ZZ (2014) Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer\u2019s disease. J Alzheimers Dis 42(Suppl 4):S411\u2013S419. doi:\n10.3233\/JAD-141467","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"9845_CR25","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/sj.jcbfm.9600259","volume":"26","author":"M Choy","year":"2006","unstructured":"Choy M, Ganesan V, Thomas DL, Thornton JS, Proctor E, King MD, van der Weerd L, Gadian DG et al (2006) The chronic vascular and haemodynamic response after permanent bilateral common carotid occlusion in newborn and adult rats. J Cereb Blood Flow Metab 26(8):1066\u20131075. doi:\n10.1038\/sj.jcbfm.9600259","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"9845_CR26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","volume":"54","author":"E Farkas","year":"2007","unstructured":"Farkas E, Luiten PG, Bari F (2007) Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev 54(1):162\u2013180. doi:\n10.1016\/j.brainresrev.2007.01.003","journal-title":"Brain Res Rev"},{"issue":"1","key":"9845_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.brainres.2006.11.035","volume":"1131","author":"T Mishima","year":"2007","unstructured":"Mishima T, Mizuguchi Y, Kawahigashi Y, Takizawa T, Takizawa T (2007) RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNS. Brain Res 1131(1):37\u201343. doi:\n10.1016\/j.brainres.2006.11.035","journal-title":"Brain Res"},{"issue":"3","key":"9845_CR28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.molcel.2007.07.015","volume":"27","author":"EV Makeyev","year":"2007","unstructured":"Makeyev EV, Zhang J, Carrasco MA, Maniatis T (2007) The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 27(3):435\u2013448. doi:\n10.1016\/j.molcel.2007.07.015","journal-title":"Mol Cell"},{"issue":"2","key":"9845_CR29","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1124\/pr.110.003707","volume":"65","author":"M Schmidt","year":"2013","unstructured":"Schmidt M, Dekker FJ, Maarsingh H (2013) Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol Rev 65(2):670\u2013709. doi:\n10.1124\/pr.110.003707","journal-title":"Pharmacol Rev"},{"issue":"5397","key":"9845_CR30","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.282.5397.2275","volume":"282","author":"H Kawasaki","year":"1998","unstructured":"Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282(5397):2275\u20132279","journal-title":"Science"},{"issue":"5","key":"9845_CR31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.tins.2010.02.001","volume":"33","author":"E Benito","year":"2010","unstructured":"Benito E, Barco A (2010) CREB\u2019s control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models. Trends Neurosci 33(5):230\u2013240. doi:\n10.1016\/j.tins.2010.02.001","journal-title":"Trends Neurosci"},{"issue":"7","key":"9845_CR32","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.cell.2004.10.032","volume":"119","author":"S Impey","year":"2004","unstructured":"Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ et al (2004) Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119(7):1041\u20131054. doi:\n10.1016\/j.cell.2004.10.032","journal-title":"Cell"},{"issue":"1","key":"9845_CR33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nsb878","volume":"10","author":"H Rehmann","year":"2003","unstructured":"Rehmann H, Prakash B, Wolf E, Rueppel A, de Rooij J, Bos JL, Wittinghofer A (2003) Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol 10(1):26\u201332. doi:\n10.1038\/nsb878","journal-title":"Nat Struct Biol"},{"issue":"1","key":"9845_CR34","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s12035-012-8355-9","volume":"47","author":"X Wang","year":"2013","unstructured":"Wang X, Wang ZH, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS et al (2013) Melatonin attenuates scopolamine-induced memory\/synaptic disorder by rescuing EPACs\/miR-124\/Egr1 pathway. Mol Neurobiol 47(1):373\u2013381. doi:\n10.1007\/s12035-012-8355-9","journal-title":"Mol Neurobiol"},{"issue":"5","key":"9845_CR35","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.neuron.2008.02.024","volume":"57","author":"Y Wen","year":"2008","unstructured":"Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marie I, Maurin T, Wang L et al (2008) Transcriptional regulation of beta-secretase by p25\/cdk5 leads to enhanced amyloidogenic processing. Neuron 57(5):680\u2013690. doi:\n10.1016\/j.neuron.2008.02.024","journal-title":"Neuron"},{"issue":"3","key":"9845_CR36","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1084\/jem.20101812","volume":"208","author":"A Courboulin","year":"2011","unstructured":"Courboulin A, Paulin R, Giguere NJ, Saksouk N, Perreault T, Meloche J, Paquet ER, Biardel S et al (2011) Role for miR-204 in human pulmonary arterial hypertension. J Exp Med 208(3):535\u2013548. doi:\n10.1084\/jem.20101812","journal-title":"J Exp Med"},{"issue":"3","key":"9845_CR37","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s12035-014-8698-5","volume":"50","author":"X Wu","year":"2014","unstructured":"Wu X, Sun J, Zhang X, Li X, Liu Z, Yang Q, Li L (2014) Epigenetic signature of chronic cerebral hypoperfusion and beneficial effects of S-adenosylmethionine in rats. Mol Neurobiol 50(3):839\u2013851. doi:\n10.1007\/s12035-014-8698-5","journal-title":"Mol Neurobiol"},{"issue":"3","key":"9845_CR38","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1750-3639.2010.00443.x","volume":"21","author":"SH Yeh","year":"2011","unstructured":"Yeh SH, Ou LC, Gean PW, Hung JJ, Chang WC (2011) Selective inhibition of early\u2014but not late\u2014expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage. Brain Pathol 21(3):249\u2013262. doi:\n10.1111\/j.1750-3639.2010.00443.x","journal-title":"Brain Pathol"},{"issue":"4","key":"9845_CR39","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/sj.cdd.4402310","volume":"15","author":"R Kulshreshtha","year":"2008","unstructured":"Kulshreshtha R, Davuluri RV, Calin GA, Ivan M (2008) A microRNA component of the hypoxic response. Cell Death Differ 15(4):667\u2013671. doi:\n10.1038\/sj.cdd.4402310","journal-title":"Cell Death Differ"},{"issue":"3","key":"9845_CR40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00424-010-0910-5","volume":"461","author":"R Pocock","year":"2011","unstructured":"Pocock R (2011) Invited review: decoding the microRNA response to hypoxia. Pflugers Arch - Eur J Physiol 461(3):307\u2013315. doi:\n10.1007\/s00424-010-0910-5","journal-title":"Pflugers Arch - Eur J Physiol"},{"issue":"4","key":"9845_CR41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4161\/epi.5.4.11684","volume":"5","author":"JA Watson","year":"2010","unstructured":"Watson JA, Watson CJ, McCann A, Baugh J (2010) Epigenetics, the epicenter of the hypoxic response. Epigenetics 5(4):293\u2013296","journal-title":"Epigenetics"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-9845-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9845-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9845-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9845-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:48:15Z","timestamp":1559429295000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-9845-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["9845"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-9845-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]}}}