{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:22:49Z","timestamp":1793766169486,"version":"4.6.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Huazhong University of Science and technology innovation fund","award":["0118530238"],"award-info":[{"award-number":["0118530238"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571286"],"award-info":[{"award-number":["81571286"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571138"],"award-info":[{"award-number":["81571138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s12035-016-9924-0","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T08:46:19Z","timestamp":1463733979000},"page":"3652-3664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Delayed Treatment with Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice"],"prefix":"10.1007","volume":"54","author":[{"given":"Jian-Cheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"key":"9924_CR1","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","volume":"371","author":"GA Donnan","year":"2008","unstructured":"Donnan GA, Fisher M, Macleod M, Davis SM (2008) Stroke. Lancet 371:1612\u20131623","journal-title":"Lancet"},{"key":"9924_CR2","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","volume":"129","author":"AS Go","year":"2014","unstructured":"Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES et al (2014) Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association. Circulation 129:e28\u2013e292","journal-title":"Circulation"},{"key":"9924_CR3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCOUTCOMES.111.000095","volume":"6","author":"LH Schwamm","year":"2013","unstructured":"Schwamm LH, Ali SF, Reeves MJ, Smith EE, Saver JL, Messe S, Bhatt DL, Grau-Sepulveda MV et al (2013) Temporal trends in patient characteristics and treatment with intravenous thrombolysis among acute ischemic stroke patients at Get With The Guidelines-Stroke hospitals. Circ Cardiovasc Qual Outcomes 6:543\u2013549","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"9924_CR4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2183\/pjab.88.88","volume":"88","author":"Y Suzuki","year":"2012","unstructured":"Suzuki Y, Miyoshi N, Isemura M (2012) Health-promoting effects of green tea. Proc Jpn Acad Ser B Phys Biol Sci 88:88\u2013101","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"9924_CR5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0091-7435(92)90041-F","volume":"21","author":"HN Graham","year":"1992","unstructured":"Graham HN (1992) Green tea composition, consumption, and polyphenol chemistry. Prev Med 21:334\u2013350","journal-title":"Prev Med"},{"key":"9924_CR6","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","volume":"82","author":"BN Singh","year":"2011","unstructured":"Singh BN, Shankar S, Srivastava RK (2011) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82:1807\u20131821","journal-title":"Biochem Pharmacol"},{"key":"9924_CR7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10787-015-0236-1","volume":"23","author":"M Afzal","year":"2015","unstructured":"Afzal M, Safer AM, Menon M (2015) Green tea polyphenols and their potential role in health and disease. Inflammopharmacology 23:151\u2013161","journal-title":"Inflammopharmacology"},{"key":"9924_CR8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3892\/mmr.2013.1778","volume":"9","author":"C Yao","year":"2014","unstructured":"Yao C, Zhang J, Liu G, Chen F, Lin Y (2014) Neuroprotection by (\u2212)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress. Mol Med Rep 9:69\u201376","journal-title":"Mol Med Rep"},{"key":"9924_CR9","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s11064-015-1647-5","volume":"40","author":"F Zhang","year":"2015","unstructured":"Zhang F, Li N, Jiang L, Chen L, Huang M (2015) Neuroprotective effects of (\u2212)-epigallocatechin-3-gallate against focal cerebral ischemia\/reperfusion injury in rats through attenuation of inflammation. Neurochem Res 40:1691\u20131698","journal-title":"Neurochem Res"},{"key":"9924_CR10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s11064-007-9494-7","volume":"33","author":"W Xie","year":"2008","unstructured":"Xie W, Ramakrishna N, Wieraszko A, Hwang YW (2008) Promotion of neuronal plasticity by (\u2212)-epigallocatechin-3-gallate. Neurochem Res 33:776\u2013783","journal-title":"Neurochem Res"},{"key":"9924_CR11","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1523\/JNEUROSCI.0914-07.2007","volume":"27","author":"H Praag van","year":"2007","unstructured":"van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M et al (2007) Plant-derived flavanol (\u2212)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci 27:5869\u20135878","journal-title":"J Neurosci"},{"key":"9924_CR12","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/mnfr.201200035","volume":"56","author":"Y Wang","year":"2012","unstructured":"Wang Y, Li M, Xu X, Song M, Tao H, Bai Y (2012) Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis. Mol Nutr Food Res 56:1292\u20131303","journal-title":"Mol Nutr Food Res"},{"key":"9924_CR13","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00702-011-0764-9","volume":"119","author":"T Itoh","year":"2012","unstructured":"Itoh T, Imano M, Nishida S, Tsubaki M, Mizuguchi N, Hashimoto S, Ito A, Satou T (2012) (\u2212)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury. J Neural Transm (Vienna) 119:877\u2013890","journal-title":"J Neural Transm (Vienna)"},{"key":"9924_CR14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuroscience.2014.06.001","volume":"274","author":"J Zhang","year":"2014","unstructured":"Zhang J, Mao X, Zhou T, Cheng X, Lin Y (2014) IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice. Neuroscience 274:419\u2013428","journal-title":"Neuroscience"},{"key":"9924_CR15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2014.07.002","volume":"1582","author":"J Zhang","year":"2014","unstructured":"Zhang J, Wu Y, Weng Z, Zhou T, Feng T, Lin Y (2014) Glycyrrhizin protects brain against ischemia-reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway. Brain Res 1582:176\u2013186","journal-title":"Brain Res"},{"key":"9924_CR16","doi-asserted-by":"crossref","first-page":"e46326","DOI":"10.1371\/journal.pone.0046326","volume":"7","author":"F Sun","year":"2012","unstructured":"Sun F, Wang X, Mao X, Xie L, Jin K (2012) Ablation of neurogenesis attenuates recovery of motor function after focal cerebral ischemia in middle-aged mice. PLoS One 7:e46326","journal-title":"PLoS One"},{"key":"9924_CR17","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/brain\/aws075","volume":"135","author":"K Gertz","year":"2012","unstructured":"Gertz K, Kronenberg G, Kalin RE, Baldinger T, Werner C, Balkaya M, Eom GD, Hellmann-Regen J et al (2012) Essential role of interleukin-6 in post-stroke angiogenesis. Brain 135:1964\u20131980","journal-title":"Brain"},{"key":"9924_CR18","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1038\/emm.2013.134","volume":"45","author":"J Song","year":"2013","unstructured":"Song J, Cho KJ, Cheon SY, Kim SH, Park KA, Lee WT, Lee JE (2013) Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury. Exp Mol Med 45:e69","journal-title":"Exp Mol Med"},{"key":"9924_CR19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbi.2014.03.013","volume":"40","author":"JA Shin","year":"2014","unstructured":"Shin JA, Lim SM, Jeong SI, Kang JL, Park EM (2014) Noggin improves ischemic brain tissue repair and promotes alternative activation of microglia in mice. Brain Behav Immun 40:143\u2013154","journal-title":"Brain Behav Immun"},{"key":"9924_CR20","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI58644","volume":"122","author":"RM Ransohoff","year":"2012","unstructured":"Ransohoff RM, Brown MA (2012) Innate immunity in the central nervous system. J Clin Invest 122:1164\u20131171","journal-title":"J Clin Invest"},{"key":"9924_CR21","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/glia.20810","volume":"57","author":"P Thored","year":"2009","unstructured":"Thored P, Heldmann U, Gomes-Leal W, Gisler R, Darsalia V, Taneera J, Nygren JM, Jacobsen SE et al (2009) Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia 57:835\u2013849","journal-title":"Glia"},{"key":"9924_CR22","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","volume":"43","author":"X Hu","year":"2012","unstructured":"Hu X, Li P, Guo Y, Wang H, Leak RK, Chen S, Gao Y, Chen J (2012) Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 43:3063\u20133070","journal-title":"Stroke"},{"key":"9924_CR23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/STROKEAHA.114.006864","volume":"46","author":"C Brifault","year":"2015","unstructured":"Brifault C, Gras M, Liot D, May V, Vaudry D, Wurtz O (2015) Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing m2 microglia\/macrophage polarization. Stroke 46:520\u2013528","journal-title":"Stroke"},{"key":"9924_CR24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.celrep.2013.12.016","volume":"6","author":"D Xu","year":"2014","unstructured":"Xu D, Zhang F, Wang Y, Sun Y, Xu Z (2014) Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Rep 6:104\u2013116","journal-title":"Cell Rep"},{"key":"9924_CR25","doi-asserted-by":"crossref","first-page":"44913","DOI":"10.1074\/jbc.M111.310052","volume":"286","author":"D Zhang","year":"2011","unstructured":"Zhang D, Guo M, Zhang W, Lu XY (2011) Adiponectin stimulates proliferation of adult hippocampal neural stem\/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)\/glycogen synthase kinase 3beta (GSK-3beta)\/beta-catenin signaling cascade. J Biol Chem 286:44913\u201344920","journal-title":"J Biol Chem"},{"key":"9924_CR26","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1002\/jnr.22495","volume":"88","author":"C Zhang","year":"2010","unstructured":"Zhang C, Chopp M, Cui Y, Wang L, Zhang R, Zhang L, Lu M, Szalad A et al (2010) Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res 88:3275\u20133281","journal-title":"J Neurosci Res"},{"key":"9924_CR27","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1523\/JNEUROSCI.5597-09.2010","volume":"30","author":"AI Rosa","year":"2010","unstructured":"Rosa AI, Goncalves J, Cortes L, Bernardino L, Malva JO, Agasse F (2010) The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem\/progenitor cells. J Neurosci 30:4573\u20134584","journal-title":"J Neurosci"},{"key":"9924_CR28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1634\/stemcells.2008-0226","volume":"27","author":"C Nicoleau","year":"2009","unstructured":"Nicoleau C, Benzakour O, Agasse F, Thiriet N, Petit J, Prestoz L, Roger M, Jaber M et al (2009) Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. Stem Cells 27:408\u2013419","journal-title":"Stem Cells"},{"key":"9924_CR29","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","volume":"8","author":"A Arvidsson","year":"2002","unstructured":"Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O (2002) Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8:963\u2013970","journal-title":"Nat Med"},{"key":"9924_CR30","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ana.10393","volume":"52","author":"JM Parent","year":"2002","unstructured":"Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM (2002) Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 52:802\u2013813","journal-title":"Ann Neurol"},{"key":"9924_CR31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","volume":"24","author":"P Thored","year":"2006","unstructured":"Thored P, Arvidsson A, Cacci E, Ahlenius H, Kallur T, Darsalia V, Ekdahl CT, Kokaia Z et al (2006) Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 24:739\u2013747","journal-title":"Stem Cells"},{"key":"9924_CR32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.10555","volume":"53","author":"J Chen","year":"2003","unstructured":"Chen J, Zhang ZG, Li Y, Wang Y, Wang L, Jiang H, Zhang C, Lu M et al (2003) Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 53:743\u2013751","journal-title":"Ann Neurol"},{"key":"9924_CR33","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.neuroscience.2008.05.056","volume":"155","author":"N Shioda","year":"2008","unstructured":"Shioda N, Han F, Morioka M, Fukunaga K (2008) Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase\/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia. Neuroscience 155:876\u2013887","journal-title":"Neuroscience"},{"key":"9924_CR34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/stem.1503","volume":"32","author":"W Fan","year":"2014","unstructured":"Fan W, Dai Y, Xu H, Zhu X, Cai P, Wang L, Sun C, Hu C et al (2014) Caspase-3 modulates regenerative response after stroke. Stem Cells 32:473\u2013486","journal-title":"Stem Cells"},{"key":"9924_CR35","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1523\/JNEUROSCI.3095-08.2009","volume":"29","author":"C Gregorian","year":"2009","unstructured":"Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M et al (2009) Pten deletion in adult neural stem\/progenitor cells enhances constitutive neurogenesis. J Neurosci 29:1874\u20131886","journal-title":"J Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-9924-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9924-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9924-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9924-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T00:02:28Z","timestamp":1567900948000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-9924-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,20]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["9924"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-9924-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,20]]}}}