{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:56:15Z","timestamp":1789692975306,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81225008"],"award-info":[{"award-number":["81225008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81161120496"],"award-info":[{"award-number":["81161120496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91332112"],"award-info":[{"award-number":["91332112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91332114"],"award-info":[{"award-number":["91332114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1405222"],"award-info":[{"award-number":["U1405222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AG021173"],"award-info":[{"award-number":["R01AG021173"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AG038710"],"award-info":[{"award-number":["R01AG038710"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AG044420"],"award-info":[{"award-number":["R01AG044420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01NS046673"],"award-info":[{"award-number":["R01NS046673"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2015Y4008"],"award-info":[{"award-number":["2015Y4008"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xiamen University President Fund","award":["20720150170"],"award-info":[{"award-number":["20720150170"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s12035-016-9997-9","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T09:34:08Z","timestamp":1466588048000},"page":"4189-4200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death"],"prefix":"10.1007","volume":"54","author":[{"given":"Qiuyang","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-wu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"9997_CR1","doi-asserted-by":"publisher","unstructured":"Green DR, Llambi F (2015) Cell death signaling. Cold Spring Harbor perspectives in biology 7 (12). doi:\n                    10.1101\/cshperspect.a006080","DOI":"10.1101\/cshperspect.a006080"},{"issue":"6","key":"9997_CR2","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s10495-006-6712-8","volume":"11","author":"N Hail Jr","year":"2006","unstructured":"Hail N Jr, Carter BZ, Konopleva M, Andreeff M (2006) Apoptosis effector mechanisms: a requiem performed in different keys. Apoptosis 11(6):889\u2013904. doi:\n                    10.1007\/s10495-006-6712-8","journal-title":"Apoptosis"},{"issue":"7","key":"9997_CR3","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/S0002-9343(00)00370-3","volume":"108","author":"C Rust","year":"2000","unstructured":"Rust C, Gores GJ (2000) Apoptosis and liver disease. Am J Med 108(7):567\u2013574","journal-title":"Am J Med"},{"issue":"31","key":"9997_CR4","doi-asserted-by":"publisher","first-page":"4058","DOI":"10.2174\/092986709789378206","volume":"16","author":"P Caroppi","year":"2009","unstructured":"Caroppi P, Sinibaldi F, Fiorucci L, Santucci R (2009) Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein. Curr Med Chem 16(31):4058\u20134065","journal-title":"Curr Med Chem"},{"issue":"1","key":"9997_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2005.03.021","volume":"39","author":"SJ van Wijk","year":"2005","unstructured":"van Wijk SJ, Hageman GJ (2005) Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia\/reperfusion. Free Radic Biol Med 39(1):81\u201390. doi:\n                    10.1016\/j.freeradbiomed.2005.03.021","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"9997_CR6","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147(4):728\u2013741. doi:\n                    10.1016\/j.cell.2011.10.026","journal-title":"Cell"},{"key":"9997_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","volume":"43","author":"C He","year":"2009","unstructured":"He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67\u201393. doi:\n                    10.1146\/annurev-genet-102808-114910","journal-title":"Annu Rev Genet"},{"issue":"52","key":"9997_CR8","doi-asserted-by":"publisher","first-page":"37298","DOI":"10.1074\/jbc.C700195200","volume":"282","author":"T Hanada","year":"2007","unstructured":"Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y (2007) The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 282(52):37298\u201337302. doi:\n                    10.1074\/jbc.C700195200","journal-title":"J Biol Chem"},{"issue":"6","key":"9997_CR9","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cell.2014.11.006","volume":"159","author":"L Galluzzi","year":"2014","unstructured":"Galluzzi L, Pietrocola F, Levine B, Kroemer G (2014) Metabolic control of autophagy. Cell 159(6):1263\u20131276. doi:\n                    10.1016\/j.cell.2014.11.006","journal-title":"Cell"},{"key":"9997_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fncel.2015.00381","volume":"9","author":"C Wilson","year":"2015","unstructured":"Wilson C, Gonzalez-Billault C (2015) Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking. Front Cell Neurosci 9:381. doi:\n                    10.3389\/fncel.2015.00381","journal-title":"Front Cell Neurosci"},{"key":"9997_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fnana.2015.00091","volume":"9","author":"J Blesa","year":"2015","unstructured":"Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR (2015) Oxidative stress and Parkinson\u2019s disease. Front Neuroanat 9:91. doi:\n                    10.3389\/fnana.2015.00091","journal-title":"Front Neuroanat"},{"issue":"4","key":"9997_CR12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","volume":"24","author":"GH Kim","year":"2015","unstructured":"Kim GH, Kim JE, Rhie SJ, Yoon S (2015) The role of oxidative stress in neurodegenerative diseases. Exp Neurobiol 24(4):325\u2013340. doi:\n                    10.5607\/en.2015.24.4.325","journal-title":"Exp Neurobiol"},{"issue":"1","key":"9997_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1006\/bbrc.1999.1481","volume":"264","author":"GC Elson","year":"1999","unstructured":"Elson GC, de Coignac AB, Aubry JP, Delneste Y, Magistrelli G, Holzwarth J, Bonnefoy JY, Gauchat JF (1999) BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. Biochem Biophys Res Commun 264(1):55\u201362. doi:\n                    10.1006\/bbrc.1999.1481","journal-title":"Biochem Biophys Res Commun"},{"issue":"27","key":"9997_CR14","doi-asserted-by":"publisher","first-page":"20664","DOI":"10.1074\/jbc.M109.055608","volume":"285","author":"S Ullrich","year":"2010","unstructured":"Ullrich S, Munch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (2010) The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J Biol Chem 285(27):20664\u201320674. doi:\n                    10.1074\/jbc.M109.055608","journal-title":"J Biol Chem"},{"issue":"5","key":"9997_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.ygeno.2005.12.009","volume":"87","author":"O Mannherz","year":"2006","unstructured":"Mannherz O, Mertens D, Hahn M, Lichter P (2006) Functional screening for proapoptotic genes by reverse transfection cell array technology. Genomics 87(5):665\u2013672. doi:\n                    10.1016\/j.ygeno.2005.12.009","journal-title":"Genomics"},{"issue":"4","key":"9997_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/emboj.2013.8","volume":"32","author":"E Boada-Romero","year":"2013","unstructured":"Boada-Romero E, Letek M, Fleischer A, Pallauf K, Ramon-Barros C, Pimentel-Muinos FX (2013) TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. EMBO J 32(4):566\u2013582. doi:\n                    10.1038\/emboj.2013.8","journal-title":"EMBO J"},{"issue":"5","key":"9997_CR17","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/nprot.2007.135","volume":"2","author":"J Luo","year":"2007","unstructured":"Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH et al (2007) A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc 2(5):1236\u20131247. doi:\n                    10.1038\/nprot.2007.135","journal-title":"Nat Protoc"},{"issue":"2","key":"9997_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1172\/JCI200317638","volume":"111","author":"H Ischiropoulos","year":"2003","unstructured":"Ischiropoulos H, Beckman JS (2003) Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest 111(2):163\u2013169. doi:\n                    10.1172\/jci17638","journal-title":"J Clin Invest"},{"issue":"6","key":"9997_CR19","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1211\/0022357041172961","volume":"56","author":"M Kajta","year":"2004","unstructured":"Kajta M (2004) Apoptosis in the central nervous system: mechanisms and protective strategies. Pol J Pharmacol 56(6):689\u2013700","journal-title":"Pol J Pharmacol"},{"issue":"5","key":"9997_CR20","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.neuint.2012.11.009","volume":"62","author":"S Manzanero","year":"2013","unstructured":"Manzanero S, Santro T, Arumugam TV (2013) Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury. Neurochem Int 62(5):712\u2013718. doi:\n                    10.1016\/j.neuint.2012.11.009","journal-title":"Neurochem Int"},{"key":"9997_CR21","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1038\/ncomms2910","volume":"4","author":"CL Cusack","year":"2013","unstructured":"Cusack CL, Swahari V, Hampton Henley W, Michael Ramsey J, Deshmukh M (2013) Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning. Nat Commun 4:1876. doi:\n                    10.1038\/ncomms2910","journal-title":"Nat Commun"},{"issue":"7232","key":"9997_CR22","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/nature07767","volume":"457","author":"A Nikolaev","year":"2009","unstructured":"Nikolaev A, McLaughlin T, O\u2019Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457(7232):981\u2013989. doi:\n                    10.1038\/nature07767","journal-title":"Nature"},{"issue":"49","key":"9997_CR23","doi-asserted-by":"publisher","first-page":"17540","DOI":"10.1523\/JNEUROSCI.3012-12.2012","volume":"32","author":"DJ Simon","year":"2012","unstructured":"Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O\u2019Leary DD, Hannoush RN et al (2012) A caspase cascade regulating developmental axon degeneration. J Neurosci 32(49):17540\u201317553. doi:\n                    10.1523\/jneurosci.3012-12.2012","journal-title":"J Neurosci"},{"issue":"2","key":"9997_CR24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0896-6273(03)00601-9","volume":"40","author":"J Yuan","year":"2003","unstructured":"Yuan J, Lipinski M, Degterev A (2003) Diversity in the mechanisms of neuronal cell death. Neuron 40(2):401\u2013413","journal-title":"Neuron"},{"key":"9997_CR25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1146\/annurev-cellbio-100913-013038","volume":"31","author":"MM Riccomagno","year":"2015","unstructured":"Riccomagno MM, Kolodkin AL (2015) Sculpting neural circuits by axon and dendrite pruning. Annu Rev Cell Dev Biol 31:779\u2013805. doi:\n                    10.1146\/annurev-cellbio-100913-013038","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"5","key":"9997_CR26","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1523\/JNEUROSCI.3121-13.2014","volume":"34","author":"A Erturk","year":"2014","unstructured":"Erturk A, Wang Y, Sheng M (2014) Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J Neurosci 34(5):1672\u20131688. doi:\n                    10.1523\/jneurosci.3121-13.2014","journal-title":"J Neurosci"},{"issue":"5","key":"9997_CR27","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.cell.2010.03.053","volume":"141","author":"Z Li","year":"2010","unstructured":"Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M (2010) Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 141(5):859\u2013871. doi:\n                    10.1016\/j.cell.2010.03.053","journal-title":"Cell"},{"issue":"10","key":"9997_CR28","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1038\/sj.npp.1301642","volume":"33","author":"GL Dalton","year":"2008","unstructured":"Dalton GL, Wang YT, Floresco SB, Phillips AG (2008) Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear. Neuropsychopharmacology 33(10):2416\u20132426. doi:\n                    10.1038\/sj.npp.1301642","journal-title":"Neuropsychopharmacology"},{"issue":"52","key":"9997_CR29","doi-asserted-by":"publisher","first-page":"20955","DOI":"10.1073\/pnas.0710548105","volume":"104","author":"J Kim","year":"2007","unstructured":"Kim J, Lee S, Park K, Hong I, Song B, Son G, Park H, Kim WR et al (2007) Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A 104(52):20955\u201320960. doi:\n                    10.1073\/pnas.0710548105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6789","key":"9997_CR30","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/35016089","volume":"405","author":"HK Lee","year":"2000","unstructured":"Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405(6789):955\u2013959. doi:\n                    10.1038\/35016089","journal-title":"Nature"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-016-9997-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9997-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9997-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-016-9997-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T16:26:50Z","timestamp":1589732810000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-016-9997-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,21]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["9997"],"URL":"https:\/\/doi.org\/10.1007\/s12035-016-9997-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,21]]},"assertion":[{"value":"22 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}