{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:55:01Z","timestamp":1773795301568,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T00:00:00Z","timestamp":1490400000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2014M3A9B6069339"],"award-info":[{"award-number":["NRF-2014M3A9B6069339"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI13C18200000"],"award-info":[{"award-number":["HI13C18200000"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s12035-017-0468-8","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T03:36:32Z","timestamp":1490412992000},"page":"2320-2332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia"],"prefix":"10.1007","volume":"55","author":[{"given":"Bhakta Prasad","family":"Gaire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yeul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerold","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-gyu","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Woong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,25]]},"reference":[{"issue":"1","key":"468_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bbalip.2012.07.015","volume":"1831","author":"JW Choi","year":"2013","unstructured":"Choi JW, Chun J (2013) Lysophospholipids and their receptors in the central nervous system. Biochim Biophys Acta 1831(1):20\u201332. doi:\n10.1016\/j.bbalip.2012.07.015","journal-title":"Biochim Biophys Acta"},{"issue":"15","key":"468_CR2","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.1111\/bph.12678","volume":"171","author":"Y Kihara","year":"2014","unstructured":"Kihara Y, Maceyka M, Spiegel S, Chun J (2014) Lysophospholipid receptor nomenclature review: IUPHAR review 8. Br J Pharmacol 171(15):3575\u20133594. doi:\n10.1111\/bph.12678","journal-title":"Br J Pharmacol"},{"issue":"5","key":"468_CR3","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/ana.22426","volume":"69","author":"JA Cohen","year":"2011","unstructured":"Cohen JA, Chun J (2011) Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Ann Neurol 69(5):759\u2013777. doi:\n10.1002\/ana.22426","journal-title":"Ann Neurol"},{"issue":"9","key":"468_CR4","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/jamaneurol.2014.1065","volume":"71","author":"Y Fu","year":"2014","unstructured":"Fu Y, Hao J, Zhang N, Ren L, Sun N, Li YJ, Yan Y, Huang D et al (2014) Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study. JAMA Neurol 71(9):1092\u20131101. doi:\n10.1001\/jamaneurol.2014.1065","journal-title":"JAMA Neurol"},{"issue":"2","key":"468_CR5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bbrc.2009.08.142","volume":"389","author":"B Czech","year":"2009","unstructured":"Czech B, Pfeilschifter W, Mazaheri-Omrani N, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A et al (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun 389(2):251\u2013256. doi:\n10.1016\/j.bbrc.2009.08.142","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"468_CR6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1161\/STROKEAHA.109.568899","volume":"41","author":"Y Hasegawa","year":"2010","unstructured":"Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH (2010) Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke 41(2):368\u2013374. doi:\n10.1161\/STROKEAHA.109.568899","journal-title":"Stroke"},{"issue":"11","key":"468_CR7","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1161\/STROKEAHA.113.002880","volume":"44","author":"P Kraft","year":"2013","unstructured":"Kraft P, Gob E, Schuhmann MK, Gobel K, Deppermann C, Thielmann I, Herrmann AM, Lorenz K et al (2013) FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke 44(11):3202\u20133210. doi:\n10.1161\/STROKEAHA.113.002880","journal-title":"Stroke"},{"key":"468_CR8","doi-asserted-by":"publisher","first-page":"492659","DOI":"10.1155\/2015\/492659","volume":"2015","author":"E Moon","year":"2015","unstructured":"Moon E, Han JE, Jeon S, Ryu JH, Choi JW, Chun J (2015) Exogenous S1P exposure potentiates ischemic stroke damage that is reduced possibly by inhibiting S1P receptor signaling. Mediat Inflamm 2015:492659. doi:\n10.1155\/2015\/492659","journal-title":"Mediat Inflamm"},{"key":"468_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.brainresbull.2016.04.004","volume":"124","author":"M Nazari","year":"2016","unstructured":"Nazari M, Keshavarz S, Rafati A, Namavar MR, Haghani M (2016) Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia. Brain Res Bull 124:95\u2013102. doi:\n10.1016\/j.brainresbull.2016.04.004","journal-title":"Brain Res Bull"},{"issue":"8","key":"468_CR10","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/nm.1999","volume":"15","author":"T Shichita","year":"2009","unstructured":"Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y et al (2009) Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med 15(8):946\u2013950. doi:\n10.1038\/nm.1999","journal-title":"Nat Med"},{"issue":"1","key":"468_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/ana.22186","volume":"69","author":"Y Wei","year":"2011","unstructured":"Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T et al (2011) Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol 69(1):119\u2013129. doi:\n10.1002\/ana.22186","journal-title":"Ann Neurol"},{"issue":"6","key":"468_CR12","doi-asserted-by":"publisher","first-page":"F1516","DOI":"10.1152\/ajprenal.00311.2005","volume":"290","author":"AS Awad","year":"2006","unstructured":"Awad AS (2006) Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol 290(6):F1516\u2013F1524. doi:\n10.1152\/ajprenal.00311.2005","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"468_CR13","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/ki.2013.345","volume":"85","author":"A Ham","year":"2013","unstructured":"Ham A, Kim M, Kim JY, Brown KM, Fruttiger M, D'Agati VD, Thomas Lee H (2013) Selective deletion of the endothelial sphingosine-1-phosphate 1 receptor exacerbates kidney ischemia\u2013reperfusion injury. Kidney Int 85(4):807\u2013823. doi:\n10.1038\/ki.2013.345","journal-title":"Kidney Int"},{"issue":"9","key":"468_CR14","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1038\/sj.ki.5000360","volume":"69","author":"YH Lien","year":"2006","unstructured":"Lien YH, Yong KC, Cho C, Igarashi S, Lai LW (2006) S1P1-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney Int 69(9):1601\u20131608. doi:\n10.1038\/sj.ki.5000360","journal-title":"Kidney Int"},{"issue":"5","key":"468_CR15","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s12975-013-0260-7","volume":"4","author":"Y Hasegawa","year":"2013","unstructured":"Hasegawa Y, Suzuki H, Altay O, Rolland W, Zhang JH (2013) Role of the sphingosine metabolism pathway on neurons against experimental cerebral ischemia in rats. Transl Stroke Res 4(5):524\u2013532. doi:\n10.1007\/s12975-013-0260-7","journal-title":"Transl Stroke Res"},{"issue":"2","key":"468_CR16","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1073\/pnas.1014154108","volume":"108","author":"JW Choi","year":"2010","unstructured":"Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC et al (2010) FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A 108(2):751\u2013756. doi:\n10.1073\/pnas.1014154108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"468_CR17","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1161\/STROKEAHA.115.012236","volume":"47","author":"N Sun","year":"2016","unstructured":"Sun N, Shen Y, Han W, Shi K, Wood K, Fu Y, Hao J, Liu Q et al (2016) Selective sphingosine-1-phosphate receptor 1 modulation attenuates experimental intracerebral hemorrhage. Stroke 47(7):1899\u20131906. doi:\n10.1161\/STROKEAHA.115.012236","journal-title":"Stroke"},{"issue":"3","key":"468_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1096\/fj.03-0910fje","volume":"18","author":"MH Graler","year":"2004","unstructured":"Graler MH, Goetzl EJ (2004) The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J 18(3):551\u2013553. doi:\n10.1096\/fj.03-0910fje","journal-title":"FASEB J"},{"issue":"12","key":"468_CR19","doi-asserted-by":"publisher","first-page":"9082","DOI":"10.1074\/jbc.M610318200","volume":"282","author":"ML Oo","year":"2007","unstructured":"Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T (2007) Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem 282(12):9082\u20139089. doi:\n10.1074\/jbc.M610318200","journal-title":"J Biol Chem"},{"key":"468_CR20","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.1038\/ncomms7416","volume":"6","author":"C Nussbaum","year":"2015","unstructured":"Nussbaum C, Bannenberg S, Keul P, Gr\u00e4ler MH, Gon\u00e7alves-de-Albuquerque CF, Korhonen H, von Wnuck LK, Heusch G et al (2015) Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun 6:6416. doi:\n10.1038\/ncomms7416","journal-title":"Nat Commun"},{"issue":"1","key":"468_CR21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s12035-014-8996-y","volume":"53","author":"JE Han","year":"2016","unstructured":"Han JE, Lee EJ, Moon E, Ryu JH, Choi JW, Kim HS (2016) Matrix metalloproteinase-8 is a novel pathogenetic factor in focal cerebral ischemia. Mol Neurobiol 53(1):231\u2013239. doi:\n10.1007\/s12035-014-8996-y","journal-title":"Mol Neurobiol"},{"issue":"11","key":"468_CR22","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.chembiol.2006.09.017","volume":"13","author":"S Pan","year":"2006","unstructured":"Pan S, Mi Y, Pally C, Beerli C, Chen A, Guerini D, Hinterding K, Nuesslein-Hildesheim B et al (2006) A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol 13(11):1227\u20131234. doi:\n10.1016\/j.chembiol.2006.09.017","journal-title":"Chem Biol"},{"issue":"3","key":"468_CR23","doi-asserted-by":"publisher","first-page":"e0120203","DOI":"10.1371\/journal.pone.0120203","volume":"10","author":"BP Gaire","year":"2015","unstructured":"Gaire BP, Kwon OW, Park SH, Chun KH, Kim SY, Shin DY, Choi JW (2015) Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One 10(3):e0120203. doi:\n10.1371\/journal.pone.0120203","journal-title":"PLoS One"},{"issue":"11","key":"468_CR24","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1007\/s11064-015-1714-y","volume":"40","author":"KS Cho","year":"2015","unstructured":"Cho KS, Lee EJ, Kim JN, Choi JW, Kim HY, Han SH, Ryu JH, Cheong JH et al (2015) Proteinase 3 induces neuronal cell death through microglial activation. Neurochem Res 40(11):2242\u20132251. doi:\n10.1007\/s11064-015-1714-y","journal-title":"Neurochem Res"},{"issue":"11","key":"468_CR25","doi-asserted-by":"publisher","first-page":"3608","DOI":"10.1161\/STROKEAHA.109.557439","volume":"40","author":"F Boscia","year":"2009","unstructured":"Boscia F, Gala R, Pannaccione A, Secondo A, Scorziello A, Di Renzo G, Annunziato L (2009) NCX1 expression and functional activity increase in microglia invading the infarct core. Stroke 40(11):3608\u20133617. doi:\n10.1161\/STROKEAHA.109.557439","journal-title":"Stroke"},{"issue":"5","key":"468_CR26","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.STR.32.5.1208","volume":"32","author":"D Ito","year":"2001","unstructured":"Ito D, Tanaka K, Suzuki S, Dembo T, Fukuuchi Y (2001) Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke 32(5):1208\u20131215","journal-title":"Stroke"},{"issue":"3","key":"468_CR27","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/jcbfm.2013.217","volume":"34","author":"HX Chu","year":"2014","unstructured":"Chu HX, Kim HA, Lee S, Moore JP, Chan CT, Vinh A, Gelderblom M, Arumugam TV et al (2014) Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia. J Cereb Blood Flow Metab 34(3):450\u2013459. doi:\n10.1038\/jcbfm.2013.217","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"468_CR28","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00702-005-0409-y","volume":"113","author":"B Engelhardt","year":"2006","unstructured":"Engelhardt B (2006) Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm (Vienna) 113(4):477\u2013485. doi:\n10.1007\/s00702-005-0409-y","journal-title":"J Neural Transm (Vienna)"},{"issue":"5","key":"468_CR29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.CIR.94.5.939","volume":"94","author":"PJ Lindsberg","year":"1996","unstructured":"Lindsberg PJ, Carpen O, Paetau A, Karjalainen-Lindsberg ML, Kaste M (1996) Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. Circulation 94(5):939\u2013945","journal-title":"Circulation"},{"issue":"3","key":"468_CR30","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.intimp.2010.10.005","volume":"11","author":"K Chiba","year":"2011","unstructured":"Chiba K, Kataoka H, Seki N, Shimano K, Koyama M, Fukunari A, Sugahara K, Sugita T (2011) Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-beta in mouse experimental autoimmune encephalomyelitis. Int Immunopharmacol 11(3):366\u2013372. doi:\n10.1016\/j.intimp.2010.10.005","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"468_CR31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3892\/br.2012.48","volume":"1","author":"A Chen","year":"2013","unstructured":"Chen A, Xiong LJ, Tong Y, Mao M (2013) The neuroprotective roles of BDNF in hypoxic ischemic brain injury. Biomed Rep 1(2):167\u2013176. doi:\n10.3892\/br.2012.48","journal-title":"Biomed Rep"},{"issue":"35","key":"468_CR32","doi-asserted-by":"publisher","first-page":"14230","DOI":"10.1073\/pnas.1206093109","volume":"109","author":"R Deogracias","year":"2012","unstructured":"Deogracias R, Yazdani M, Dekkers MP, Guy J, Ionescu MC, Vogt KE, Barde YA (2012) Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. Proc Natl Acad Sci U S A 109(35):14230\u201314235. doi:\n10.1073\/pnas.1206093109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"468_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.11.006","author":"S O'Sullivan","year":"2016","unstructured":"O'Sullivan S, Dev KK (2016) Sphingosine-1-phosphate receptor therapies: advances in clinical trials for CNS-related diseases. Neuropharmacology. doi:\n10.1016\/j.neuropharm.2016.11.006","journal-title":"Neuropharmacology"},{"issue":"2","key":"468_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1124\/jpet.107.127183","volume":"323","author":"CA Foster","year":"2007","unstructured":"Foster CA, Howard LM, Schweitzer A, Persohn E, Hiestand PC, Balatoni B, Reuschel R, Beerli C et al (2007) Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J Pharmacol Exp Ther 323(2):469\u2013475. doi:\n10.1124\/jpet.107.127183","journal-title":"J Pharmacol Exp Ther"},{"issue":"7","key":"468_CR35","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.4049\/jimmunol.1102261","volume":"189","author":"G Galicia-Rosas","year":"2012","unstructured":"Galicia-Rosas G, Pikor N, Schwartz JA, Rojas O, Jian A, Summers-Deluca L, Ostrowski M, Nuesslein-Hildesheim B et al (2012) A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a Plasmacytoid dendritic cell-dependent manner. J Immunol 189(7):3700\u20133706. doi:\n10.4049\/jimmunol.1102261","journal-title":"J Immunol"},{"issue":"1","key":"468_CR36","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.neuroscience.2009.12.020","volume":"166","author":"D Nayak","year":"2010","unstructured":"Nayak D, Huo Y, Kwang WXT, Pushparaj PN, Kumar SD, Ling EA, Dheen ST (2010) Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience 166(1):132\u2013144. doi:\n10.1016\/j.neuroscience.2009.12.020","journal-title":"Neuroscience"},{"issue":"2","key":"468_CR37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.pbb.2012.08.025","volume":"103","author":"F Gao","year":"2012","unstructured":"Gao F, Liu Y, Li X, Wang Y, Wei D, Jiang W (2012) Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model. Pharmacol Biochem Behav 103(2):187\u2013196. doi:\n10.1016\/j.pbb.2012.08.025","journal-title":"Pharmacol Biochem Behav"},{"key":"468_CR38","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12974-015-0308-6","volume":"12","author":"R Cipriani","year":"2015","unstructured":"Cipriani R, Chara JC, Rodriguez-Antiguedad A, Matute C (2015) FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation 12:86. doi:\n10.1186\/s12974-015-0308-6","journal-title":"J Neuroinflammation"},{"issue":"1\u20132","key":"468_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jneuroim.2012.12.005","volume":"256","author":"H Noda","year":"2013","unstructured":"Noda H, Takeuchi H, Mizuno T, Suzumura A (2013) Fingolimod phosphate promotes the neuroprotective effects of microglia. J Neuroimmunol 256(1\u20132):13\u201318. doi:\n10.1016\/j.jneuroim.2012.12.005","journal-title":"J Neuroimmunol"},{"issue":"12","key":"468_CR40","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1002\/glia.22890","volume":"63","author":"T Sawano","year":"2015","unstructured":"Sawano T, Watanabe F, Ishiguchi M, Doe N, Furuyama T, Inagaki S (2015) Effect of Sema4D on microglial function in middle cerebral artery occlusion mice. Glia 63(12):2249\u20132259. doi:\n10.1002\/glia.22890","journal-title":"Glia"},{"issue":"5","key":"468_CR41","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1189\/jlb.1109766","volume":"87","author":"R Jin","year":"2010","unstructured":"Jin R, Yang G, Li G (2010) Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 87(5):779\u2013789. doi:\n10.1189\/jlb.1109766","journal-title":"J Leukoc Biol"},{"issue":"22","key":"468_CR42","doi-asserted-by":"publisher","first-page":"20026","DOI":"10.1074\/jbc.M109218200","volume":"277","author":"H Kanazawa","year":"2002","unstructured":"Kanazawa H, Ohsawa K, Sasaki Y, Kohsaka S, Imai Y (2002) Macrophage\/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma-dependent pathway. J Biol Chem 277(22):20026\u201320032. doi:\n10.1074\/jbc.M109218200","journal-title":"J Biol Chem"},{"issue":"Pt 12","key":"468_CR43","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1093\/brain\/awt287","volume":"136","author":"T Li","year":"2013","unstructured":"Li T, Pang S, Yu Y, Wu X, Guo J, Zhang S (2013) Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain 136(Pt 12):3578\u20133588. doi:\n10.1093\/brain\/awt287","journal-title":"Brain"},{"issue":"2","key":"468_CR44","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/glia.20159","volume":"50","author":"R Ladeby","year":"2005","unstructured":"Ladeby R, Wirenfeldt M, Dalmau I, Gregersen R, Garcia-Ovejero D, Babcock A, Owens T, Finsen B (2005) Proliferating resident microglia express the stem cell antigen CD34 in response to acute neural injury. Glia 50(2):121\u2013131. doi:\n10.1002\/glia.20159","journal-title":"Glia"},{"issue":"12","key":"468_CR45","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/nn2014","volume":"10","author":"B Ajami","year":"2007","unstructured":"Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 10(12):1538\u20131543. doi:\n10.1038\/nn2014","journal-title":"Nat Neurosci"},{"issue":"11","key":"468_CR46","doi-asserted-by":"publisher","first-page":"e27881","DOI":"10.1371\/journal.pone.0027881","volume":"6","author":"GE Barreto","year":"2011","unstructured":"Barreto GE, Sun X, Xu L, Giffard RG (2011) Astrocyte proliferation following stroke in the mouse depends on distance from the infarct. PLoS One 6(11):e27881. doi:\n10.1371\/journal.pone.0027881","journal-title":"PLoS One"},{"issue":"49","key":"468_CR47","doi-asserted-by":"publisher","first-page":"16467","DOI":"10.1523\/JNEUROSCI.2582-14.2014","volume":"34","author":"D Yang","year":"2014","unstructured":"Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH et al (2014) Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci 34(49):16467\u201316481. doi:\n10.1523\/JNEUROSCI.2582-14.2014","journal-title":"J Neurosci"},{"issue":"2","key":"468_CR48","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s12031-011-9496-4","volume":"44","author":"H Jiao","year":"2011","unstructured":"Jiao H, Wang Z, Liu Y, Wang P, Xue Y (2011) Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood\u2013brain barrier in a focal cerebral ischemic insult. J Mol Neurosci 44(2):130\u2013139. doi:\n10.1007\/s12031-011-9496-4","journal-title":"J Mol Neurosci"},{"issue":"7","key":"468_CR49","doi-asserted-by":"publisher","first-page":"e70124","DOI":"10.1371\/journal.pone.0070124","volume":"8","author":"R Brunkhorst","year":"2013","unstructured":"Brunkhorst R, Kanaan N, Koch A, Ferreiros N, Mirceska A, Zeiner P, Mittelbronn M, Derouiche A et al (2013) FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke. PLoS One 8(7):e70124. doi:\n10.1371\/journal.pone.0070124","journal-title":"PLoS One"},{"issue":"4","key":"468_CR50","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2174\/1567202613666160823152446","volume":"13","author":"MK Schuhmann","year":"2016","unstructured":"Schuhmann MK, Krstic M, Kleinschnitz C, Fluri F (2016) Fingolimod (FTY720) reduces cortical infarction and neurological deficits during ischemic stroke through potential maintenance of microvascular patency. Curr Neurovasc Res 13(4):277\u2013282","journal-title":"Curr Neurovasc Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-017-0468-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0468-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0468-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T23:06:42Z","timestamp":1520291202000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-017-0468-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,25]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["468"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0468-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,25]]}}}