{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:10:42Z","timestamp":1787688642540,"version":"build-2784847793"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81525020"],"award-info":[{"award-number":["81525020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81502033"],"award-info":[{"award-number":["81502033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81272300"],"award-info":[{"award-number":["81272300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["31570753"],"award-info":[{"award-number":["31570753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12035-017-0531-5","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T05:51:36Z","timestamp":1492494696000},"page":"15251-15266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity"],"prefix":"10.1007","volume":"62","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang-Long","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang-Ye","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"issue":"4","key":"531_CR1","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/j.1460-9568.2008.06061.x","volume":"27","author":"AB Gyorgy","year":"2008","unstructured":"Gyorgy AB, Szemes M, de Juan RC, Tarabykin V, Agoston DV (2008) SATB2 interacts with chromatin-remodeling molecules in differentiating cortical neurons. Eur J Neurosci 27(4):865\u2013873. doi:10.1111\/j.1460-9568.2008.06061.x","journal-title":"Eur J Neurosci"},{"issue":"3","key":"531_CR2","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1111\/j.1460-9568.2005.03897.x","volume":"21","author":"O Britanova","year":"2005","unstructured":"Britanova O, Akopov S, Lukyanov S, Gruss P, Tarabykin V (2005) Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Eur J Neurosci 21(3):658\u2013668. doi:10.1111\/j.1460-9568.2005.03897.x","journal-title":"Eur J Neurosci"},{"issue":"19","key":"531_CR3","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1093\/hmg\/ddg248","volume":"12","author":"DR Fitz Patrick","year":"2003","unstructured":"Fitz Patrick DR, Carr IM, McLaren L, Leek JP, Wightman P, Williamson K, Gautier P, McGill N et al (2003) Identification of SATB2 as the cleft palate gene on 2q32-q33. Hum Mol Genet 12(19):2491\u20132501. doi:10.1093\/hmg\/ddg248","journal-title":"Hum Mol Genet"},{"issue":"2","key":"531_CR4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1086\/302498","volume":"65","author":"CM Brewer","year":"1999","unstructured":"Brewer CM, Leek JP, Green AJ, Holloway S, Bonthron DT, Markham AF, FitzPatrick DR (1999) A locus for isolated cleft palate, located on human chromosome 2q32. Am J Hum Genet 65(2):387\u2013396. doi:10.1086\/302498","journal-title":"Am J Hum Genet"},{"issue":"3","key":"531_CR5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1399-0004.2008.01145.x","volume":"75","author":"DH Tegay","year":"2009","unstructured":"Tegay DH, Chan KK, Leung L, Wang C, Burkett S, Stone G, Stanyon R, Toriello HV et al (2009) Toriello-Carey syndrome in a patient with a de novo balanced translocation [46,XY,t(2;14)(q33;q22)] interrupting SATB2. Clin Genet 75(3):259\u2013264. doi:10.1111\/j.1399-0004.2008.01145.x","journal-title":"Clin Genet"},{"issue":"3","key":"531_CR6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.cell.2012.03.028","volume":"149","author":"ME Talkowski","year":"2012","unstructured":"Talkowski ME, Rosenfeld JA, Blumenthal I, Pillalamarri V, Chiang C, Heilbut A, Ernst C, Hanscom C et al (2012) Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell 149(3):525\u2013537. doi:10.1016\/j.cell.2012.03.028","journal-title":"Cell"},{"issue":"5","key":"531_CR7","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1136\/jmg.2010.084491","volume":"48","author":"M Balasubramanian","year":"2011","unstructured":"Balasubramanian M, Smith K, Basel-Vanagaite L, Feingold MF, Brock P, Gowans GC, Vasudevan PC, Cresswell L et al (2011) Case series: 2q33.1 microdeletion syndrome\u2014further delineation of the phenotype. J Med Genet 48(5):290\u2013298. doi:10.1136\/jmg.2010.084491","journal-title":"J Med Genet"},{"issue":"3","key":"531_CR8","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ejmg.2005.05.005","volume":"48","author":"G Van Buggenhout","year":"2005","unstructured":"Van Buggenhout G, Van Ravenswaaij-Arts C, Mc Maas N, Thoelen R, Vogels A, Smeets D, Salden I, Matthijs G et al (2005) The del(2)(q32.2q33) deletion syndrome defined by clinical and molecular characterization of four patients. European journal of medical genetics 48(3):276\u2013289. doi:10.1016\/j.ejmg.2005.05.005","journal-title":"European journal of medical genetics"},{"issue":"2\u20133","key":"531_CR9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ejmg.2009.01.002","volume":"52","author":"TJ de Ravel","year":"2009","unstructured":"de Ravel TJ, Balikova I, Thiry P, Vermeesch JR, Frijns JP (2009) Another patient with a de novo deletion further delineates the 2q33.1 microdeletion syndrome. European journal of medical genetics 52(2\u20133):120\u2013122. doi:10.1016\/j.ejmg.2009.01.002","journal-title":"European journal of medical genetics"},{"issue":"5","key":"531_CR10","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1002\/ajmg.a.36849","volume":"167A","author":"YA Zarate","year":"2015","unstructured":"Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O et al (2015) Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A 167A(5):1026\u20131032. doi:10.1002\/ajmg.a.36849","journal-title":"Am J Med Genet A"},{"issue":"8","key":"531_CR11","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/ejhg.2013.280","volume":"22","author":"D Docker","year":"2014","unstructured":"Docker D, Schubach M, Menzel M, Munz M, Spaich C, Biskup S, Bartholdi D (2014) Further delineation of the SATB2 phenotype. European journal of human genetics: EJHG 22(8):1034\u20131039. doi:10.1038\/ejhg.2013.280","journal-title":"European journal of human genetics: EJHG"},{"issue":"6","key":"531_CR12","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/cge.12698","volume":"89","author":"JS Lee","year":"2016","unstructured":"Lee JS, Yoo Y, Lim BC, Kim KJ, Choi M, Chae JH (2016) SATB2-associated syndrome presenting with Rett-like phenotypes. Clin Genet 89(6):728\u2013732. doi:10.1111\/cge.12698","journal-title":"Clin Genet"},{"issue":"7","key":"531_CR13","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1002\/humu.20515","volume":"28","author":"P Leoyklang","year":"2007","unstructured":"Leoyklang P, Suphapeetiporn K, Siriwan P, Desudchit T, Chaowanapanja P, Gahl WA, Shotelersuk V (2007) Heterozygous nonsense mutation SATB2 associated with cleft palate, osteoporosis, and cognitive defects. Hum Mutat 28(7):732\u2013738. doi:10.1002\/humu.20515","journal-title":"Hum Mutat"},{"issue":"3","key":"531_CR14","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.neuron.2007.12.028","volume":"57","author":"O Britanova","year":"2008","unstructured":"Britanova O, de Juan RC, Cheung A, Kwan KY, Schwark M, Gyorgy A, Vogel T, Akopov S et al (2008) Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57(3):378\u2013392. doi:10.1016\/j.neuron.2007.12.028","journal-title":"Neuron"},{"issue":"3","key":"531_CR15","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.neuron.2007.12.012","volume":"57","author":"EA Alcamo","year":"2008","unstructured":"Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Farinas I, Grosschedl R, McConnell SK (2008) Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57(3):364\u2013377. doi:10.1016\/j.neuron.2007.12.012","journal-title":"Neuron"},{"key":"531_CR16","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1038\/ncomms4708","volume":"5","author":"S Srivatsa","year":"2014","unstructured":"Srivatsa S, Parthasarathy S, Britanova O, Bormuth I, Donahoo AL, Ackerman SL, Richards LJ, Tarabykin V (2014) Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. Nat Commun 5:3708. doi:10.1038\/ncomms4708","journal-title":"Nat Commun"},{"issue":"3","key":"531_CR17","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/ana.10119","volume":"51","author":"D Bonneau","year":"2002","unstructured":"Bonneau D, Toutain A, Laquerriere A, Marret S, Saugier-Veber P, Barthez MA, Radi S, Biran-Mucignat V et al (2002) X-linked lissencephaly with absent corpus callosum and ambiguous genitalia (XLAG): clinical, magnetic resonance imaging, and neuropathological findings. Ann Neurol 51(3):340\u2013349","journal-title":"Ann Neurol"},{"issue":"3","key":"531_CR18","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/ar.22656","volume":"296","author":"Y Huang","year":"2013","unstructured":"Huang Y, Song NN, Lan W, Hu L, Su CJ, Ding YQ, Zhang L (2013) Expression of transcription factor Satb2 in adult mouse brain. Anat Rec 296(3):452\u2013461. doi:10.1002\/ar.22656","journal-title":"Anat Rec"},{"key":"531_CR19","doi-asserted-by":"publisher","first-page":"e17361","DOI":"10.7554\/eLife.17361","volume":"5","author":"C Jaitner","year":"2016","unstructured":"Jaitner C, Reddy C, Abentung A, Whittle N, Rieder D, Delekate A, Korte M, Jain G et al (2016) Satb2 determines miRNA expression and long-term memory in the adult central nervous system. elife 5:e17361","journal-title":"elife"},{"issue":"4","key":"531_CR20","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","volume":"35","author":"N Burgess","year":"2002","unstructured":"Burgess N, Maguire EA, O'Keefe J (2002) The human hippocampus and spatial and episodic memory. Neuron 35(4):625\u2013641","journal-title":"Neuron"},{"issue":"20","key":"531_CR21","doi-asserted-by":"publisher","first-page":"11280","DOI":"10.1073\/pnas.93.20.11280","volume":"93","author":"L Nyberg","year":"1996","unstructured":"Nyberg L, McIntosh AR, Cabeza R, Habib R, Houle S, Tulving E (1996) General and specific brain regions involved in encoding and retrieval of events: what, where, and when. Proc Natl Acad Sci 93(20):11280\u201311285","journal-title":"Proc Natl Acad Sci"},{"issue":"7351","key":"531_CR22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature10163","volume":"474","author":"WC Skarnes","year":"2011","unstructured":"Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M et al (2011) A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474(7351):337\u2013342. doi:10.1038\/nature10163","journal-title":"Nature"},{"issue":"1","key":"531_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/S0006-8993(98)01191-3","volume":"835","author":"EJ Nestler","year":"1999","unstructured":"Nestler EJ, Kelz MB, Chen J (1999) \u0394FosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res 835(1):10\u201317","journal-title":"Brain Res"},{"issue":"40","key":"531_CR24","doi-asserted-by":"publisher","first-page":"13773","DOI":"10.1523\/JNEUROSCI.2083-15.2015","volume":"35","author":"AL Eagle","year":"2015","unstructured":"Eagle AL, Gajewski PA, Yang M, Kechner ME, Al Masraf BS, Kennedy PJ, Wang H et al (2015) Experience-dependent induction of hippocampal \u0394FosB controls learning. J Neurosci 35(40):13773\u201313783","journal-title":"J Neurosci"},{"issue":"1","key":"531_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nn.2467","volume":"13","author":"L Madisen","year":"2010","unstructured":"Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, Ng LL, Palmiter RD et al (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133\u2013140","journal-title":"Nat Neurosci"},{"issue":"8","key":"531_CR26","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/nn.3744","volume":"17","author":"B Li","year":"2014","unstructured":"Li B, Jie W, Huang L, Wei P, Li S, Luo Z, Friedman AK, Meredith AL et al (2014) Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci 17(8):1055\u20131063. doi:10.1038\/nn.3744","journal-title":"Nat Neurosci"},{"issue":"38","key":"531_CR27","doi-asserted-by":"publisher","first-page":"8528","DOI":"10.3748\/wjg.v22.i38.8528","volume":"22","author":"Y Li","year":"2016","unstructured":"Li Y, Liu Y-H, Hu Y-Y, Chen L, Li J-M (2016) Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells. World J Gastroenterol 22(38):8528","journal-title":"World J Gastroenterol"},{"issue":"2","key":"531_CR28","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"CV Vorhees","year":"2006","unstructured":"Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1(2):848\u2013858. doi:10.1038\/nprot.2006.116","journal-title":"Nat Protoc"},{"issue":"1","key":"531_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nprot.2006.2","volume":"1","author":"RM Deacon","year":"2006","unstructured":"Deacon RM, Rawlins JN (2006) T-maze alternation in the rodent. Nat Protoc 1(1):7\u201312. doi:10.1038\/nprot.2006.2","journal-title":"Nat Protoc"},{"issue":"6","key":"531_CR30","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nm.3162","volume":"19","author":"X Cao","year":"2013","unstructured":"Cao X, Li LP, Wang Q, Wu Q, Hu HH, Zhang M, Fang YY, Zhang J et al (2013) Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med 19(6):773\u2013777. doi:10.1038\/nm.3162","journal-title":"Nat Med"},{"key":"531_CR31","unstructured":"Konsman J-P (2003) The mouse brain in stereotaxic coordinates: (Deluxe) by Paxinos G. and Franklin, KBJ, Academic Press, New York, 2001, ISBN 0\u201312-547637-X. Pergamon"},{"issue":"3","key":"531_CR32","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s12035-014-8917-0","volume":"52","author":"JH Liu","year":"2015","unstructured":"Liu JH, You QL, Wei MD, Wang Q, Luo ZY, Lin S, Huang L, Li SJ et al (2015) Social isolation during adolescence strengthens retention of fear memories and facilitates induction of late-phase long-term potentiation. Mol Neurobiol 52(3):1421\u20131429. doi:10.1007\/s12035-014-8917-0","journal-title":"Mol Neurobiol"},{"issue":"5","key":"531_CR33","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neuron.2014.10.024","volume":"84","author":"Z \u0160i\u0161kov\u00e1","year":"2014","unstructured":"\u0160i\u0161kov\u00e1 Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S et al (2014) Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer\u2019s disease. Neuron 84(5):1023\u20131033. doi:10.1016\/j.neuron.2014.10.024","journal-title":"Neuron"},{"issue":"2","key":"531_CR34","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1128\/MCB.05917-11","volume":"32","author":"MA Balamotis","year":"2012","unstructured":"Balamotis MA, Tamberg N, Woo YJ, Li J, Davy B, Kohwi-Shigematsu T, Kohwi Y (2012) Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development. Mol Cell Biol 32(2):333\u2013347. doi:10.1128\/MCB.05917-11","journal-title":"Mol Cell Biol"},{"issue":"2","key":"531_CR35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.molcel.2016.05.039","volume":"63","author":"R Jain","year":"2016","unstructured":"Jain R, Iglesias N, Moazed D (2016) Distinct functions of argonaute slicer in siRNA maturation and heterochromatin formation. Mol Cell 63(2):191\u2013205. doi:10.1016\/j.molcel.2016.05.039","journal-title":"Mol Cell"},{"issue":"1","key":"531_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/gene.1078","volume":"31","author":"E Casanova","year":"2001","unstructured":"Casanova E, Fehsenfeld S, Mantamadiotis T, Lemberger T, Greiner E, Stewart AF, Schutz G (2001) A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis 31(1):37\u201342","journal-title":"Genesis"},{"issue":"6407","key":"531_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"TV Bliss","year":"1993","unstructured":"Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407):31\u201339","journal-title":"Nature"},{"key":"531_CR38","doi-asserted-by":"publisher","unstructured":"Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R (2014) Engineering a memory with LTD and LTP. Nature 511:348\u2013352. doi:10.1038\/nature13294","DOI":"10.1038\/nature13294"},{"issue":"1","key":"531_CR39","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0896-6273(01)00194-5","volume":"29","author":"W-Y Lu","year":"2001","unstructured":"Lu W-Y, Man H-Y, Ju W, Trimble WS, MacDonald JF, Wang YT (2001) Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 29(1):243\u2013254","journal-title":"Neuron"},{"issue":"1","key":"531_CR40","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cell.2014.03.001","volume":"157","author":"ER Kandel","year":"2014","unstructured":"Kandel ER, Dudai Y, Mayford MR (2014) The molecular and systems biology of memory. Cell 157(1):163\u2013186. doi:10.1016\/j.cell.2014.03.001","journal-title":"Cell"},{"issue":"2\u20133","key":"531_CR41","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF03033816","volume":"14","author":"I Izquierdo","year":"2008","unstructured":"Izquierdo I, Bevilaqua LM, Rossato JI, Da Silva WC, Bonini J, Medina JH, Cammarota M (2008) The molecular cascades of long-term potentiation underlie memory consolidation of one-trial avoidance in the CA1 region of the dorsal hippocampus, but not in the basolateral amygdala or the neocortex. Neurotox Res 14(2\u20133):273\u2013294","journal-title":"Neurotox Res"},{"issue":"3","key":"531_CR42","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neures.2010.12.007","volume":"69","author":"H Okuno","year":"2011","unstructured":"Okuno H (2011) Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers. Neurosci Res 69(3):175\u2013186. doi:10.1016\/j.neures.2010.12.007","journal-title":"Neurosci Res"},{"issue":"27","key":"531_CR43","doi-asserted-by":"publisher","first-page":"9116","DOI":"10.1523\/JNEUROSCI.23-27-09116.2003","volume":"23","author":"A Fleischmann","year":"2003","unstructured":"Fleischmann A, Hvalby O, Jensen V, Strekalova T, Zacher C, Layer LE, Kvello A, Reschke M et al (2003) Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci 23(27):9116\u20139122","journal-title":"J Neurosci"},{"issue":"3","key":"531_CR44","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.neuron.2006.08.024","volume":"52","author":"N Plath","year":"2006","unstructured":"Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A et al (2006) Arc\/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52(3):437\u2013444. doi:10.1016\/j.neuron.2006.08.024","journal-title":"Neuron"},{"issue":"3","key":"531_CR45","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/85138","volume":"4","author":"M Jones","year":"2001","unstructured":"Jones M, Errington M, French P, Fine A, Bliss T, Garel S, Charnay P, Bozon B et al (2001) A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci 4(3):289\u2013296","journal-title":"Nat Neurosci"},{"issue":"2","key":"531_CR46","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.molbrainres.2004.05.014","volume":"132","author":"CA McClung","year":"2004","unstructured":"McClung CA, Ulery PG, Perrotti LI, Zachariou V, Berton O, Nestler EJ (2004) DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res 132(2):146\u2013154. doi:10.1016\/j.molbrainres.2004.05.014","journal-title":"Brain Res Mol Brain Res"},{"issue":"7","key":"531_CR47","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1093\/cercor\/bhr215","volume":"22","author":"L Zhang","year":"2012","unstructured":"Zhang L, Song NN, Chen JY, Huang Y, Li H, Ding YQ (2012) Satb2 is required for dendritic arborization and soma spacing in mouse cerebral cortex. Cereb Cortex 22(7):1510\u20131519. doi:10.1093\/cercor\/bhr215","journal-title":"Cereb Cortex"},{"issue":"2","key":"531_CR48","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.neuron.2007.11.034","volume":"57","author":"VH Brun","year":"2008","unstructured":"Brun VH, Leutgeb S, Wu HQ, Schwarcz R, Witter MP, Moser EI, Moser MB (2008) Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex. Neuron 57(2):290\u2013302. doi:10.1016\/j.neuron.2007.11.034","journal-title":"Neuron"},{"issue":"6061","key":"531_CR49","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1126\/science.1210125","volume":"334","author":"J Suh","year":"2011","unstructured":"Suh J, Rivest AJ, Nakashiba T, Tominaga T, Tonegawa S (2011) Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory. Science 334(6061):1415\u20131420. doi:10.1126\/science.1210125","journal-title":"Science"},{"issue":"6173","key":"531_CR50","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1126\/science.1244634","volume":"343","author":"T Kitamura","year":"2014","unstructured":"Kitamura T, Pignatelli M, Suh J, Kohara K, Yoshiki A, Abe K, Tonegawa S (2014) Island cells control temporal association memory. Science 343(6173):896\u2013901. doi:10.1126\/science.1244634","journal-title":"Science"},{"issue":"3","key":"531_CR51","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/cne.903070308","volume":"307","author":"MP Witter","year":"1991","unstructured":"Witter MP, Amaral DG (1991) Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex. J Comp Neurol 307(3):437\u2013459","journal-title":"J Comp Neurol"},{"issue":"2","key":"531_CR52","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.neuron.2014.02.031","volume":"82","author":"D Meyer","year":"2014","unstructured":"Meyer D, Bonhoeffer T, Scheuss V (2014) Balance and stability of synaptic structures during synaptic plasticity. Neuron 82(2):430\u2013443. doi:10.1016\/j.neuron.2014.02.031","journal-title":"Neuron"},{"issue":"3","key":"531_CR53","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","volume":"89","author":"Y Lu","year":"2008","unstructured":"Lu Y, Christian K, Lu B (2008) BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89(3):312\u2013323. doi:10.1016\/j.nlm.2007.08.018","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"531_CR54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neuron.2005.09.005","volume":"48","author":"A Barco","year":"2005","unstructured":"Barco A, Patterson SL, Alarcon JM, Gromova P, Mata-Roig M, Morozov A, Kandel ER (2005) Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 48(1):123\u2013137. doi:10.1016\/j.neuron.2005.09.005","journal-title":"Neuron"},{"issue":"3","key":"531_CR55","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.nlm.2007.08.012","volume":"89","author":"T Miyashita","year":"2008","unstructured":"Miyashita T, Kubik S, Lewandowski G, Guzowski JF (2008) Networks of neurons, networks of genes: an integrated view of memory consolidation. Neurobiol Learn Mem 89(3):269\u2013284","journal-title":"Neurobiol Learn Mem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0531-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-017-0531-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0531-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:02:54Z","timestamp":1761908574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-017-0531-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["531"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0531-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]},"assertion":[{"value":"1 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"This work was supported by the National Nature Science Foundation of China (Grants 81,525,020, 81,502,033, 81,272,300, 31570753, 31430032 and U1201225).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Grant Support"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}