{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:42:01Z","timestamp":1790534521209,"version":"4.1.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ministry of Science Research and Technology (R.O.C)","award":["MOST 105-2628-B-010-006\u2013MY3"],"award-info":[{"award-number":["MOST 105-2628-B-010-006\u2013MY3"]}]},{"name":"Ministry of Science Research and Technology (R.O.C)","award":["MOST 103-2321-B-010-016"],"award-info":[{"award-number":["MOST 103-2321-B-010-016"]}]},{"name":"Ministry of Science and Technology (R.O.C)","award":["MOST 104-2314-B-006-030-MY3"],"award-info":[{"award-number":["MOST 104-2314-B-006-030-MY3"]}]},{"name":"Ministry of Science and Technology (R.O.C)","award":["MOST 99-2628-B-006-013-MY3"],"award-info":[{"award-number":["MOST 99-2628-B-006-013-MY3"]}]},{"name":"YEN TJING LING MEDICAL FUNDATION,Taiwan","award":["CI-105-12"],"award-info":[{"award-number":["CI-105-12"]}]},{"name":"National Yang-Ming University-Far Eastern Memorial Hospital Joint Research Program","award":["#NYMU-FEMH 106DN09"],"award-info":[{"award-number":["#NYMU-FEMH 106DN09"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s12035-017-0685-1","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T06:43:32Z","timestamp":1500619412000},"page":"4811-4824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model"],"prefix":"10.1007","volume":"55","author":[{"given":"Han-Fang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Wei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-9293","authenticated-orcid":false,"given":"Hui-Ching","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"issue":"2","key":"685_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2&lt;247::AID-CNE8&gt;3.0.CO;2-2","volume":"370","author":"PM Rodier","year":"1996","unstructured":"Rodier PM, Ingram JL, Tisdale B, Nelson S, Romano J (1996) Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol 370(2):247\u2013261. doi: 10.1002\/(SICI)1096-9861(19960624)370:2&lt;247::AID-CNE8&gt;3.0.CO;2-2","journal-title":"J Comp Neurol"},{"issue":"5","key":"685_CR2","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.pcl.2008.07.005","volume":"55","author":"I Rapin","year":"2008","unstructured":"Rapin I, Tuchman RF (2008) Autism: definition, neurobiology, screening, diagnosis. Pediatr Clin N Am 55(5):1129\u20131146, viii. doi: 10.1016\/j.pcl.2008.07.005","journal-title":"Pediatr Clin N Am"},{"issue":"1","key":"685_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3109\/1547691X.2010.545086","volume":"8","author":"HV Ratajczak","year":"2011","unstructured":"Ratajczak HV (2011) Theoretical aspects of autism: causes\u2014a review. J Immunotoxicol 8(1):68\u201379. doi: 10.3109\/1547691X.2010.545086","journal-title":"J Immunotoxicol"},{"key":"685_CR4","doi-asserted-by":"publisher","first-page":"7168","DOI":"10.1038\/ncomms8168","volume":"6","author":"EJ Lee","year":"2015","unstructured":"Lee EJ, Lee H, Huang TN, Chung C, Shin W, Kim K, Koh JY, Hsueh YP et al (2015) Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation. Nat Commun 6:7168. doi: 10.1038\/ncomms8168","journal-title":"Nat Commun"},{"issue":"1","key":"685_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s10882-014-9397-x","volume":"27","author":"E Rubenstein","year":"2015","unstructured":"Rubenstein E, Wiggins LD, Lee LC (2015) A review of the differences in developmental, psychiatric, and medical endophenotypes between males and females with autism spectrum disorder. J Dev Phys Disabil 27(1):119\u2013139. doi: 10.1007\/s10882-014-9397-x","journal-title":"J Dev Phys Disabil"},{"issue":"2","key":"685_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/WCO.0b013e32835ee548","volume":"26","author":"DM Werling","year":"2013","unstructured":"Werling DM, Geschwind DH (2013) Sex differences in autism spectrum disorders. Curr Opin Neurol 26(2):146\u2013153. doi: 10.1097\/WCO.0b013e32835ee548","journal-title":"Curr Opin Neurol"},{"issue":"11","key":"685_CR7","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1038\/nn.4420","volume":"19","author":"Y Sztainberg","year":"2016","unstructured":"Sztainberg Y, Zoghbi HY (2016) Lessons learned from studying syndromic autism spectrum disorders. Nat Neurosci 19(11):1408\u20131417. doi: 10.1038\/nn.4420","journal-title":"Nat Neurosci"},{"issue":"7402","key":"685_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nature11208","volume":"486","author":"H Won","year":"2012","unstructured":"Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J, Ha S, Chung C et al (2012) Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486(7402):261\u2013265. doi: 10.1038\/nature11208","journal-title":"Nature"},{"issue":"3","key":"685_CR9","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nn.3927","volume":"18","author":"W Chung","year":"2015","unstructured":"Chung W, Choi SY, Lee E, Park H, Kang J, Choi Y, Lee D, Park SG et al (2015) Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression. Nat Neurosci 18(3):435\u2013443. doi: 10.1038\/nn.3927","journal-title":"Nat Neurosci"},{"issue":"9","key":"685_CR10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0165-6147(90)90184-A","volume":"11","author":"B Meldrum","year":"1990","unstructured":"Meldrum B, Garthwaite J (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 11(9):379\u2013387","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"685_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/2045-5380-3-11","volume":"3","author":"SG Hofmann","year":"2013","unstructured":"Hofmann SG, Wu JQ, Boettcher H (2013) D-cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders. Biol Mood Anxiety Disorders 3(1):11. doi: 10.1186\/2045-5380-3-11","journal-title":"Biol Mood Anxiety Disorders"},{"issue":"4","key":"685_CR12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.31887\/DCNS.2011.13.4\/mdavis","volume":"13","author":"M Davis","year":"2011","unstructured":"Davis M (2011) NMDA receptors and fear extinction: implications for cognitive behavioral therapy. Dialogues Clin Neurosci 13(4):463\u2013474","journal-title":"Dialogues Clin Neurosci"},{"issue":"2","key":"685_CR13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0893-133X(99)00014-7","volume":"21","author":"BN Berckel van","year":"1999","unstructured":"van Berckel BN, Evenblij CN, van Loon BJ, Maas MF, van der Geld MA, Wynne HJ, van Ree JM, Kahn RS (1999) D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: a double-blind, parallel, placebo-controlled study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 21(2):203\u2013210. doi: 10.1016\/S0893-133X(99)00014-7","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"key":"685_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.pnpbp.2013.02.017","volume":"44","author":"J Ren","year":"2013","unstructured":"Ren J, Li X, Zhang X, Li M, Wang Y, Ma Y (2013) The effects of intra-hippocampal microinfusion of D-cycloserine on fear extinction, and the expression of NMDA receptor subunit NR2B and neurogenesis in the hippocampus in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 44:257\u2013264. doi: 10.1016\/j.pnpbp.2013.02.017","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"11","key":"685_CR15","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1176\/appi.ajp.161.11.2115","volume":"161","author":"DJ Posey","year":"2004","unstructured":"Posey DJ, Kem DL, Swiezy NB, Sweeten TL, Wiegand RE, McDougle CJ (2004) A pilot study of D-cycloserine in subjects with autistic disorder. Am J Psychiatry 161(11):2115\u20132117. doi: 10.1176\/appi.ajp.161.11.2115","journal-title":"Am J Psychiatry"},{"issue":"3","key":"685_CR16","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/WNF.0000000000000033","volume":"37","author":"M Urbano","year":"2014","unstructured":"Urbano M, Okwara L, Manser P, Hartmann K, Herndon A, Deutsch SI (2014) A trial of D-cycloserine to treat stereotypies in older adolescents and young adults with autism spectrum disorder. Clin Neuropharmacol 37(3):69\u201372. doi: 10.1097\/WNF.0000000000000033","journal-title":"Clin Neuropharmacol"},{"key":"685_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13229-017-0116-1","volume":"8","author":"LK Wink","year":"2017","unstructured":"Wink LK, Minshawi NF, Shaffer RC, Plawecki MH, Posey DJ, Horn PS, Adams R, Pedapati EV et al (2017) D-cycloserine enhances durability of social skills training in autism spectrum disorder. Molecular Autism 8:2. doi: 10.1186\/s13229-017-0116-1","journal-title":"Molecular Autism"},{"key":"685_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13229-015-0062-8","volume":"7","author":"NF Minshawi","year":"2016","unstructured":"Minshawi NF, Wink LK, Shaffer R, Plawecki MH, Posey DJ, Liu H, Hurwitz S, McDougle CJ et al (2016) A randomized, placebo-controlled trial of D-cycloserine for the enhancement of social skills training in autism spectrum disorders. Molecular Autism 7:2. doi: 10.1186\/s13229-015-0062-8","journal-title":"Molecular Autism"},{"issue":"6","key":"685_CR19","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1523\/JNEUROSCI.4517-09.2010","volume":"30","author":"J Blundell","year":"2010","unstructured":"Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C, Bolliger MF, Sudhof TC et al (2010) Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience 30(6):2115\u20132129. doi: 10.1523\/JNEUROSCI.4517-09.2010","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"685_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2350-5-10","volume":"5","author":"S Ramanathan","year":"2004","unstructured":"Ramanathan S, Woodroffe A, Flodman PL, Mays LZ, Hanouni M, Modahl CB, Steinberg-Epstein R, Bocian ME et al (2004) A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC Med Genet 5:10. doi: 10.1186\/1471-2350-5-10","journal-title":"BMC Med Genet"},{"issue":"2","key":"685_CR21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1037\/0735-7044.120.2.241","volume":"120","author":"AN Mead","year":"2006","unstructured":"Mead AN, Morris HV, Dixon CI, Rulten SL, Mayne LV, Zamanillo D, Stephens DN (2006) AMPA receptor GluR2, but not GluR1, subunit deletion impairs emotional response conditioning in mice. Behav Neurosci 120(2):241\u2013248. doi: 10.1037\/0735-7044.120.2.241","journal-title":"Behav Neurosci"},{"issue":"50","key":"685_CR22","doi-asserted-by":"publisher","first-page":"E6964","DOI":"10.1073\/pnas.1512913112","volume":"112","author":"J Li","year":"2015","unstructured":"Li J, Chai A, Wang L, Ma Y, Wu Z, Yu H, Mei L, Lu L et al (2015) Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. Proc Natl Acad Sci U S A 112(50):E6964\u2013E6972. doi: 10.1073\/pnas.1512913112","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"39","key":"685_CR23","doi-asserted-by":"publisher","first-page":"15537","DOI":"10.1073\/pnas.0707484104","volume":"104","author":"M Nakamoto","year":"2007","unstructured":"Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST (2007) Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A 104(39):15537\u201315542. doi: 10.1073\/pnas.0707484104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"685_CR24","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/sj.bjp.0705541","volume":"140","author":"E Rouaud","year":"2003","unstructured":"Rouaud E, Billard JM (2003) D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol 140(6):1051\u20131056. doi: 10.1038\/sj.bjp.0705541","journal-title":"Br J Pharmacol"},{"issue":"13","key":"685_CR25","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1038\/npp.2008.30","volume":"33","author":"SC Mao","year":"2008","unstructured":"Mao SC, Lin HC, Gean PW (2008) Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 33(13):3085\u20133095. doi: 10.1038\/npp.2008.30","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"key":"685_CR26","doi-asserted-by":"publisher","unstructured":"Wu HF, Chen PS, Chen YJ, Lee CW, Chen IT, Lin HC (2016) Alleviation of N-methyl-D-aspartate receptor-dependent long-term depression via regulation of the glycogen synthase kinase-3beta pathway in the amygdala of a valproic acid-induced animal model of autism. Mol Neurobiol. doi: 10.1007\/s12035-016-0074-1","DOI":"10.1007\/s12035-016-0074-1"},{"issue":"2","key":"685_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.toxlet.2010.12.018","volume":"201","author":"KC Kim","year":"2011","unstructured":"Kim KC, Kim P, Go HS, Choi CS, Yang SI, Cheong JH, Shin CY, Ko KH (2011) The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats. Toxicol Lett 201(2):137\u2013142. doi: 10.1016\/j.toxlet.2010.12.018","journal-title":"Toxicol Lett"},{"issue":"4","key":"685_CR28","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/mrdd.20039","volume":"10","author":"JN Crawley","year":"2004","unstructured":"Crawley JN (2004) Designing mouse behavioral tasks relevant to autistic-like behaviors. Ment Retard Dev Disabil Res Rev 10(4):248\u2013258. doi: 10.1002\/mrdd.20039","journal-title":"Ment Retard Dev Disabil Res Rev"},{"issue":"3","key":"685_CR29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","volume":"14","author":"S Pellow","year":"1985","unstructured":"Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14(3):149\u2013167","journal-title":"J Neurosci Methods"},{"issue":"6","key":"685_CR30","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1037\/0735-7044.114.6.1119","volume":"114","author":"L Lacroix","year":"2000","unstructured":"Lacroix L, Spinelli S, Heidbreder CA, Feldon J (2000) Differential role of the medial and lateral prefrontal cortices in fear and anxiety. Behav Neurosci 114(6):1119\u20131130","journal-title":"Behav Neurosci"},{"issue":"22","key":"685_CR31","doi-asserted-by":"publisher","first-page":"9069","DOI":"10.1073\/pnas.0811949106","volume":"106","author":"LM Pyter","year":"2009","unstructured":"Pyter LM, Pineros V, Galang JA, McClintock MK, Prendergast BJ (2009) Peripheral tumors induce depressive-like behaviors and cytokine production and alter hypothalamic-pituitary-adrenal axis regulation. Proc Natl Acad Sci U S A 106(22):9069\u20139074. doi: 10.1073\/pnas.0811949106","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"685_CR32","doi-asserted-by":"publisher","first-page":"e59580","DOI":"10.1371\/journal.pone.0059580","volume":"8","author":"SC Mao","year":"2013","unstructured":"Mao SC, Chang CH, Wu CC, Orejarena MJ, Manzoni OJ, Gean PW (2013) Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training. PLoS One 8(3):e59580. doi: 10.1371\/journal.pone.0059580","journal-title":"PLoS One"},{"issue":"5","key":"685_CR33","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.neuron.2004.11.011","volume":"44","author":"Q Zhou","year":"2004","unstructured":"Zhou Q, Homma KJ, Poo MM (2004) Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44(5):749\u2013757. doi: 10.1016\/j.neuron.2004.11.011","journal-title":"Neuron"},{"issue":"12","key":"685_CR34","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1016\/j.bbadis.2013.08.012","volume":"1832","author":"KO Lai","year":"2013","unstructured":"Lai KO, Ip NY (2013) Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders. Biochim Biophys Acta 1832(12):2257\u20132263. doi: 10.1016\/j.bbadis.2013.08.012","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"685_CR35","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1073\/pnas.0711412105","volume":"105","author":"V Biou","year":"2008","unstructured":"Biou V, Bhattacharyya S, Malenka RC (2008) Endocytosis and recycling of AMPA receptors lacking GluR2\/3. Proc Natl Acad Sci U S A 105(3):1038\u20131043. doi: 10.1073\/pnas.0711412105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"685_CR36","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0896-6273(00)81067-3","volume":"25","author":"HY Man","year":"2000","unstructured":"Man HY, Lin JW, Ju WH, Ahmadian G, Liu L, Becker LE, Sheng M, Wang YT (2000) Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron 25(3):649\u2013662","journal-title":"Neuron"},{"issue":"3","key":"685_CR37","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0896-6273(00)81066-1","volume":"25","author":"YT Wang","year":"2000","unstructured":"Wang YT, Linden DJ (2000) Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 25(3):635\u2013647","journal-title":"Neuron"},{"issue":"5","key":"685_CR38","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1038\/sj.emboj.7600126","volume":"23","author":"G Ahmadian","year":"2004","unstructured":"Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y et al (2004) Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. EMBO J 23(5):1040\u20131050. doi: 10.1038\/sj.emboj.7600126","journal-title":"EMBO J"},{"issue":"52","key":"685_CR39","doi-asserted-by":"publisher","first-page":"20955","DOI":"10.1073\/pnas.0710548105","volume":"104","author":"J Kim","year":"2007","unstructured":"Kim J, Lee S, Park K, Hong I, Song B, Son G, Park H, Kim WR et al (2007) Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A 104(52):20955\u201320960. doi: 10.1073\/pnas.0710548105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"685_CR40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0959-4388(96)80076-6","volume":"6","author":"M Gallagher","year":"1996","unstructured":"Gallagher M, Chiba AA (1996) The amygdala and emotion. Curr Opin Neurobiol 6(2):221\u2013227","journal-title":"Curr Opin Neurobiol"},{"issue":"3","key":"685_CR41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0149-7634(00)00011-7","volume":"24","author":"S Baron-Cohen","year":"2000","unstructured":"Baron-Cohen S, Ring HA, Bullmore ET, Wheelwright S, Ashwin C, Williams SC (2000) The amygdala theory of autism. Neurosci Biobehav Rev 24(3):355\u2013364","journal-title":"Neurosci Biobehav Rev"},{"issue":"52","key":"685_CR42","doi-asserted-by":"publisher","first-page":"21180","DOI":"10.1073\/pnas.1219167110","volume":"109","author":"MG Baxter","year":"2012","unstructured":"Baxter MG, Croxson PL (2012) Facing the role of the amygdala in emotional information processing. Proc Natl Acad Sci U S A 109(52):21180\u201321181. doi: 10.1073\/pnas.1219167110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"685_CR43","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nn.3626","volume":"17","author":"TN Huang","year":"2014","unstructured":"Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ, Hsueh YP (2014) Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci 17(2):240\u2013247. doi: 10.1038\/nn.3626","journal-title":"Nat Neurosci"},{"issue":"1","key":"685_CR44","doi-asserted-by":"publisher","first-page":"e55248","DOI":"10.1371\/journal.pone.0055248","volume":"8","author":"HC Lin","year":"2013","unstructured":"Lin HC, Gean PW, Wang CC, Chan YH, Chen PS (2013) The amygdala excitatory\/inhibitory balance in a valproate-induced rat autism model. PLoS One 8(1):e55248. doi: 10.1371\/journal.pone.0055248","journal-title":"PLoS One"},{"key":"685_CR45","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fnbeh.2014.00219","volume":"8","author":"YW Chen","year":"2014","unstructured":"Chen YW, Lin HC, Ng MC, Hsiao YH, Wang CC, Gean PW, Chen PS (2014) Activation of mGluR2\/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Front Behav Neurosci 8:219. doi: 10.3389\/fnbeh.2014.00219","journal-title":"Front Behav Neurosci"},{"issue":"4","key":"685_CR46","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/sj.npp.1301453","volume":"33","author":"K Markram","year":"2008","unstructured":"Markram K, Rinaldi T, La Mendola D, Sandi C, Markram H (2008) Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacol: Off Publ Am College Neuropsychopharmacology 33(4):901\u2013912. doi: 10.1038\/sj.npp.1301453","journal-title":"Neuropsychopharmacol: Off Publ Am College Neuropsychopharmacology"},{"issue":"6114","key":"685_CR47","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1126\/science.1227764","volume":"338","author":"BJ O'Roak","year":"2012","unstructured":"O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG, Carvill G, Kumar A et al (2012) Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science 338(6114):1619\u20131622. doi: 10.1126\/science.1227764","journal-title":"Science"},{"issue":"8","key":"685_CR48","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/mp.2013.127","volume":"19","author":"EM Kenny","year":"2014","unstructured":"Kenny EM, Cormican P, Furlong S, Heron E, Kenny G, Fahey C, Kelleher E, Ennis S et al (2014) Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders. Mol Psychiatry 19(8):872\u2013879. doi: 10.1038\/mp.2013.127","journal-title":"Mol Psychiatry"},{"key":"685_CR49","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1038\/tp.2011.52","volume":"1","author":"J Tarabeux","year":"2011","unstructured":"Tarabeux J, Kebir O, Gauthier J, Hamdan FF, Xiong L, Piton A, Spiegelman D, Henrion E et al (2011) Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Transl Psychiatry 1:e55. doi: 10.1038\/tp.2011.52","journal-title":"Transl Psychiatry"},{"issue":"2","key":"685_CR50","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neulet.2012.01.061","volume":"512","author":"HJ Yoo","year":"2012","unstructured":"Yoo HJ, Cho IH, Park M, Yang SY, Kim SA (2012) Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders. Neurosci Lett 512(2):89\u201393. doi: 10.1016\/j.neulet.2012.01.061","journal-title":"Neurosci Lett"},{"key":"685_CR51","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.coph.2014.10.007","volume":"20","author":"EJ Lee","year":"2015","unstructured":"Lee EJ, Choi SY, Kim E (2015) NMDA receptor dysfunction in autism spectrum disorders. Curr Opin Pharmacol 20:8\u201313. doi: 10.1016\/j.coph.2014.10.007","journal-title":"Curr Opin Pharmacol"},{"key":"685_CR52","doi-asserted-by":"publisher","unstructured":"Lee E, Lee J, Kim E (2016) Excitation\/inhibition imbalance in animal models of autism spectrum disorders. Biol Psychiatry. doi: 10.1016\/j.biopsych.2016.05.011","DOI":"10.1016\/j.biopsych.2016.05.011"},{"issue":"7","key":"685_CR53","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/mp.2015.139","volume":"21","author":"M Pilorge","year":"2016","unstructured":"Pilorge M, Fassier C, Le Corronc H, Potey A, Bai J, De Gois S, Delaby E, Assouline B et al (2016) Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Mol Psychiatry 21(7):936\u2013945. doi: 10.1038\/mp.2015.139","journal-title":"Mol Psychiatry"},{"issue":"33","key":"685_CR54","doi-asserted-by":"publisher","first-page":"13501","DOI":"10.1073\/pnas.0704391104","volume":"104","author":"T Rinaldi","year":"2007","unstructured":"Rinaldi T, Kulangara K, Antoniello K, Markram H (2007) Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid. Proc Natl Acad Sci U S A 104(33):13501\u201313506. doi: 10.1073\/pnas.0704391104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"685_CR55","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fnmol.2015.00017","volume":"8","author":"J Kang","year":"2015","unstructured":"Kang J, Kim E (2015) Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors. Front Mol Neurosci 8:17. doi: 10.3389\/fnmol.2015.00017","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"685_CR56","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2217\/fnl.11.55","volume":"6","author":"J Dhawan","year":"2011","unstructured":"Dhawan J, Benveniste H, Luo Z, Nawrocky M, Smith SD, Biegon A (2011) A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke. Future Neurol 6(6):823\u2013834. doi: 10.2217\/fnl.11.55","journal-title":"Future Neurol"},{"issue":"1\u20133","key":"685_CR57","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ejphar.2009.11.066","volume":"629","author":"A Adeleye","year":"2010","unstructured":"Adeleye A, Shohami E, Nachman D, Alexandrovich A, Trembovler V, Yaka R, Shoshan Y, Dhawan J et al (2010) D-cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window. Eur J Pharmacol 629(1\u20133):25\u201330. doi: 10.1016\/j.ejphar.2009.11.066","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"685_CR58","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0166-2236(93)90197-T","volume":"16","author":"RC Malenka","year":"1993","unstructured":"Malenka RC, Nicoll RA (1993) NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms. Trends Neurosci 16(12):521\u2013527","journal-title":"Trends Neurosci"},{"issue":"3","key":"685_CR59","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.conb.2012.01.007","volume":"22","author":"DL Hunt","year":"2012","unstructured":"Hunt DL, Castillo PE (2012) Synaptic plasticity of NMDA receptors: mechanisms and functional implications. Curr Opin Neurobiol 22(3):496\u2013508. doi: 10.1016\/j.conb.2012.01.007","journal-title":"Curr Opin Neurobiol"},{"issue":"12","key":"685_CR60","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1038\/81823","volume":"3","author":"EC Beattie","year":"2000","unstructured":"Beattie EC, Carroll RC, Yu X, Morishita W, Yasuda H, von Zastrow M, Malenka RC (2000) Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci 3(12):1291\u20131300. doi: 10.1038\/81823","journal-title":"Nat Neurosci"},{"issue":"1","key":"685_CR61","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(01)00194-5","volume":"29","author":"W Lu","year":"2001","unstructured":"Lu W, Man H, Ju W, Trimble WS, MacDonald JF, Wang YT (2001) Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 29(1):243\u2013254","journal-title":"Neuron"},{"issue":"2","key":"685_CR62","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/mp.2015.20","volume":"21","author":"S Chanda","year":"2016","unstructured":"Chanda S, Aoto J, Lee SJ, Wernig M, Sudhof TC (2016) Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Mol Psychiatry 21(2):169\u2013177. doi: 10.1038\/mp.2015.20","journal-title":"Mol Psychiatry"},{"issue":"11","key":"685_CR63","doi-asserted-by":"publisher","first-page":"E1575","DOI":"10.1073\/pnas.1517244113","volume":"113","author":"W Li","year":"2016","unstructured":"Li W, Xu X, Pozzo-Miller L (2016) Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors. Proc Natl Acad Sci U S A 113(11):E1575\u2013E1584. doi: 10.1073\/pnas.1517244113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"685_CR64","doi-asserted-by":"publisher","first-page":"4920","DOI":"10.1073\/pnas.1102233108","volume":"108","author":"R Mejias","year":"2011","unstructured":"Mejias R, Adamczyk A, Anggono V, Niranjan T, Thomas GM, Sharma K, Skinner C, Schwartz CE et al (2011) Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proc Natl Acad Sci U S A 108(12):4920\u20134925. doi: 10.1073\/pnas.1102233108","journal-title":"Proc Natl Acad Sci U S A"},{"key":"685_CR65","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bbr.2016.12.042","volume":"321","author":"M Han","year":"2017","unstructured":"Han M, Mejias R, Chiu SL, Rose R, Adamczyk A, Huganir R, Wang T (2017) Mice lacking GRIP1\/2 show increased social interactions and enhanced phosphorylation at GluA2-S880. Behav Brain Res 321:176\u2013184. doi: 10.1016\/j.bbr.2016.12.042","journal-title":"Behav Brain Res"},{"issue":"32","key":"685_CR66","doi-asserted-by":"publisher","first-page":"10026","DOI":"10.1073\/pnas.1512786112","volume":"112","author":"HL Tan","year":"2015","unstructured":"Tan HL, Queenan BN, Huganir RL (2015) GRIP1 is required for homeostatic regulation of AMPAR trafficking. Proc Natl Acad Sci U S A 112(32):10026\u201310031. doi: 10.1073\/pnas.1512786112","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"685_CR67","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00213-013-3048-2","volume":"228","author":"TT Duan","year":"2013","unstructured":"Duan TT, Tan JW, Yuan Q, Cao J, Zhou QX, Xu L (2013) Acute ketamine induces hippocampal synaptic depression and spatial memory impairment through dopamine D1\/D5 receptors. Psychopharmacology 228(3):451\u2013461. doi: 10.1007\/s00213-013-3048-2","journal-title":"Psychopharmacology"},{"issue":"3","key":"685_CR68","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nn.2741","volume":"14","author":"P Penzes","year":"2011","unstructured":"Penzes P, Cahill ME, Jones KA, VanLeeuwen JE, Woolfrey KM (2011) Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci 14(3):285\u2013293. doi: 10.1038\/nn.2741","journal-title":"Nat Neurosci"},{"issue":"49","key":"685_CR69","doi-asserted-by":"publisher","first-page":"19553","DOI":"10.1073\/pnas.0704031104","volume":"104","author":"SK Ultanir","year":"2007","unstructured":"Ultanir SK, Kim JE, Hall BJ, Deerinck T, Ellisman M, Ghosh A (2007) Regulation of spine morphology and spine density by NMDA receptor signaling in vivo. Proc Natl Acad Sci U S A 104(49):19553\u201319558. doi: 10.1073\/pnas.0704031104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"28","key":"685_CR70","doi-asserted-by":"publisher","first-page":"7365","DOI":"10.1523\/JNEUROSCI.0956-07.2007","volume":"27","author":"VA Alvarez","year":"2007","unstructured":"Alvarez VA, Ridenour DA, Sabatini BL (2007) Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. J Neurosci 27(28):7365\u20137376. doi: 10.1523\/JNEUROSCI.0956-07.2007","journal-title":"J Neurosci"},{"issue":"1","key":"685_CR71","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1523\/JNEUROSCI.1034-10.2011","volume":"31","author":"BS Chen","year":"2011","unstructured":"Chen BS, Thomas EV, Sanz-Clemente A, Roche KW (2011) NMDA receptor-dependent regulation of dendritic spine morphology by SAP102 splice variants. J Neurosci 31(1):89\u201396. doi: 10.1523\/JNEUROSCI.1034-10.2011","journal-title":"J Neurosci"},{"key":"685_CR72","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.neuropharm.2015.02.013","volume":"93","author":"SC Gupta","year":"2015","unstructured":"Gupta SC, Yadav R, Pavuluri R, Morley BJ, Stairs DJ, Dravid SM (2015) Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity. Neuropharmacology 93:274\u2013284. doi: 10.1016\/j.neuropharm.2015.02.013","journal-title":"Neuropharmacology"},{"issue":"4","key":"685_CR73","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nn1672","volume":"9","author":"R Lamprecht","year":"2006","unstructured":"Lamprecht R, Farb CR, Rodrigues SM, LeDoux JE (2006) Fear conditioning drives profilin into amygdala dendritic spines. Nat Neurosci 9(4):481\u2013483. doi: 10.1038\/nn1672","journal-title":"Nat Neurosci"},{"issue":"3","key":"685_CR74","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/j.1460-9568.2006.04962.x","volume":"24","author":"JJ Radley","year":"2006","unstructured":"Radley JJ, Johnson LR, Janssen WG, Martino J, Lamprecht R, Hof PR, LeDoux JE, Morrison JH (2006) Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala. Eur J Neurosci 24(3):876\u2013884. doi: 10.1111\/j.1460-9568.2006.04962.x","journal-title":"Eur J Neurosci"},{"issue":"4","key":"685_CR75","doi-asserted-by":"publisher","first-page":"e94787","DOI":"10.1371\/journal.pone.0094787","volume":"9","author":"B Calabrese","year":"2014","unstructured":"Calabrese B, Saffin JM, Halpain S (2014) Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. PLoS One 9(4):e94787. doi: 10.1371\/journal.pone.0094787","journal-title":"PLoS One"},{"issue":"2","key":"685_CR76","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1385\/MN:29:2:117","volume":"29","author":"B Leuner","year":"2004","unstructured":"Leuner B, Shors TJ (2004) New spines, new memories. Mol Neurobiol 29(2):117\u2013130. doi: 10.1385\/MN:29:2:117","journal-title":"Mol Neurobiol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-017-0685-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0685-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0685-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T07:55:03Z","timestamp":1659254103000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-017-0685-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["685"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0685-1","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,21]]}}}