{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:42:11Z","timestamp":1777498931726,"version":"3.51.4"},"reference-count":146,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008383","name":"Stichting ParkinsonFonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008383","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NWO\/ZonMw","award":["VENI 916.12.167"],"award-info":[{"award-number":["VENI 916.12.167"]}]},{"name":"The Netherlands Brain Foundation","award":["F2014(1)-16"],"award-info":[{"award-number":["F2014(1)-16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s12035-017-0775-0","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T10:10:20Z","timestamp":1507630220000},"page":"5639-5657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Physical Exercise Modulates L-DOPA-Regulated Molecular Pathways in the MPTP Mouse Model of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"55","author":[{"given":"Cornelius J. H. M.","family":"Klemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Xicoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Poelmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas R.","family":"Bloem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard J. M.","family":"Martens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper E.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"issue":"15","key":"775_CR1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al (2008) Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23(15):2129\u20132170","journal-title":"Mov Disord"},{"issue":"12","key":"775_CR2","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/mds.26291","volume":"30","author":"FJ David","year":"2015","unstructured":"David FJ, Robichaud JA, Leurgans SE, Poon C, Kohrt WM, Goldman JG et al (2015) Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial. Mov Disord 30(12):1657\u20131663","journal-title":"Mov Disord"},{"issue":"Suppl 1","key":"775_CR3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/jnc.13691","volume":"139","author":"S Sveinbjornsdottir","year":"2016","unstructured":"Sveinbjornsdottir S (2016) The clinical symptoms of Parkinson's disease. J Neurochem 139(Suppl 1):318\u2013324","journal-title":"J Neurochem"},{"issue":"7","key":"775_CR4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM196702162760703","volume":"276","author":"GC Cotzias","year":"1967","unstructured":"Cotzias GC, Van Woert MH, Schiffer LM (1967) Aromatic amino acids and modification of parkinsonism. N Engl J Med 276(7):374\u2013379","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"775_CR5","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mds.23829","volume":"26","author":"SH Fox","year":"2011","unstructured":"Fox SH, Katzenschlager R, Lim SY, Ravina B, Seppi K, Coelho M et al (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the motor symptoms of Parkinson's disease. Mov Disord 26(Suppl 3):S2\u201341","journal-title":"Mov Disord"},{"issue":"10","key":"775_CR6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/WNR.0b013e328361dc13","volume":"24","author":"BE Fisher","year":"2013","unstructured":"Fisher BE, Li Q, Nacca A, Salem GJ, Song J, Yip J et al (2013) Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease. Neuroreport 24(10):509\u2013514","journal-title":"Neuroreport"},{"issue":"20","key":"775_CR7","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1523\/JNEUROSCI.1069-07.2007","volume":"27","author":"GM Petzinger","year":"2007","unstructured":"Petzinger GM, Walsh JP, Akopian G, Hogg E, Abernathy A, Arevalo P et al (2007) Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci Off J Soc Neurosci 27(20):5291\u20135300","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"5","key":"775_CR8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/01.jsm.0000244612.55550.7d","volume":"16","author":"AM Crizzle","year":"2006","unstructured":"Crizzle AM, Newhouse IJ (2006) Is physical exercise beneficial for persons with Parkinson's disease? Clin J Sport Med 16(5):422\u2013425","journal-title":"Clin J Sport Med"},{"issue":"7","key":"775_CR9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/jnnp.2009.174987","volume":"81","author":"T Muller","year":"2010","unstructured":"Muller T, Muhlack S (2010) Effect of exercise on reactivity and motor behaviour in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 81(7):747\u2013753","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"775_CR10","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/mds.25380","volume":"28","author":"DM Corcos","year":"2013","unstructured":"Corcos DM, Robichaud JA, David FJ, Leurgans SE, Vaillancourt DE, Poon C et al (2013) A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease. Mov Disord 28(9):1230\u20131240","journal-title":"Mov Disord"},{"issue":"7","key":"775_CR11","doi-asserted-by":"crossref","first-page":"e0181515","DOI":"10.1371\/journal.pone.0181515","volume":"12","author":"PL Wu","year":"2017","unstructured":"Wu PL, Lee M, Huang TT (2017) Effectiveness of physical activity on patients with depression and Parkinson's disease: a systematic review. PLoS One 12(7):e0181515","journal-title":"PLoS One"},{"issue":"11","key":"775_CR12","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.apmr.2012.05.015","volume":"93","author":"AL Ridgel","year":"2012","unstructured":"Ridgel AL, Peacock CA, Fickes EJ, Kim CH (2012) Active-assisted cycling improves tremor and bradykinesia in Parkinson's disease. Arch Phys Med Rehabil 93(11):2049\u20132054","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"775_CR13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/09593985.2014.972530","volume":"31","author":"M Uygur","year":"2015","unstructured":"Uygur M, Bellumori M, LeNoir K, Poole K, Pretzer-Aboff I, Knight CA (2015) Immediate effects of high-speed cycling intervals on bradykinesia in Parkinson's disease. Physiother Theory Pract 31(2):77\u201382","journal-title":"Physiother Theory Pract"},{"issue":"4","key":"775_CR14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2340\/16501977-1931","volume":"47","author":"J Marusiak","year":"2015","unstructured":"Marusiak J, Zeligowska E, Mencel J, Kisiel-Sajewicz K, Majerczak J, Zoladz JA et al (2015) Interval training-induced alleviation of rigidity and hypertonia in patients with Parkinson's disease is accompanied by increased basal serum brain-derived neurotrophic factor. J Rehabil Med 47(4):372\u2013375","journal-title":"J Rehabil Med"},{"issue":"1","key":"775_CR15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/NPT.0000000000000117","volume":"40","author":"S Klamroth","year":"2016","unstructured":"Klamroth S, Steib S, Devan S, Pfeifer K (2016) Effects of exercise therapy on postural instability in Parkinson disease: a meta-analysis. J Neurol Phys Ther 40(1):3\u201314","journal-title":"J Neurol Phys Ther"},{"issue":"2","key":"775_CR16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ctim.2015.01.010","volume":"23","author":"H Hashimoto","year":"2015","unstructured":"Hashimoto H, Takabatake S, Miyaguchi H, Nakanishi H, Naitou Y (2015) Effects of dance on motor functions, cognitive functions, and mental symptoms of Parkinson's disease: a quasi-randomized pilot trial. Complement Ther Med 23(2):210\u2013219","journal-title":"Complement Ther Med"},{"issue":"1","key":"775_CR17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/mds.26484","volume":"31","author":"GO Reynolds","year":"2016","unstructured":"Reynolds GO, Otto MW, Ellis TD, Cronin-Golomb A (2016) The therapeutic potential of exercise to improve mood, cognition, and sleep in Parkinson's disease. Mov Disord 31(1):23\u201338","journal-title":"Mov Disord"},{"issue":"1","key":"775_CR18","first-page":"19","volume":"1","author":"GE Meredith","year":"2011","unstructured":"Meredith GE, Rademacher DJ (2011) MPTP mouse models of Parkinson's disease: an update. J Park Dis 1(1):19\u201333","journal-title":"J Park Dis"},{"issue":"3\u20134","key":"775_CR19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12640-010-9168-0","volume":"18","author":"T Archer","year":"2010","unstructured":"Archer T, Fredriksson A (2010) Physical exercise attenuates MPTP-induced deficits in mice. Neurotox Res 18(3\u20134):313\u2013327","journal-title":"Neurotox Res"},{"issue":"3","key":"775_CR20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00702-010-0474-8","volume":"118","author":"A Fredriksson","year":"2011","unstructured":"Fredriksson A, Stigsdotter IM, Hurtig A, Ewalds-Kvist B, Archer T (2011) Running wheel activity restores MPTP-induced functional deficits. J Neural Transm 118(3):407\u2013420","journal-title":"J Neural Transm"},{"issue":"7","key":"775_CR21","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1460-9568.2011.07626.x","volume":"33","author":"YS Lau","year":"2011","unstructured":"Lau YS, Patki G, Das-Panja K, Le WD, Ahmad SO (2011) Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration. Eur J Neurosci 33(7):1264\u20131274","journal-title":"Eur J Neurosci"},{"issue":"1","key":"775_CR22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12640-015-9566-4","volume":"29","author":"AS Aguiar Jr","year":"2016","unstructured":"Aguiar AS Jr, Lopes SC, Tristao FS, Rial D, de Oliveira G, da Cunha C et al (2016) Exercise improves cognitive impairment and dopamine metabolism in MPTP-treated mice. Neurotox Res 29(1):118\u2013125","journal-title":"Neurotox Res"},{"key":"775_CR23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuroscience.2017.07.031","volume":"359","author":"MJ Churchill","year":"2017","unstructured":"Churchill MJ, Pflibsen L, Sconce MD, Moore C, Kim K, Meshul CK (2017) Exercise in an animal model of Parkinson's disease: Motor recovery but not restoration of the nigrostriatal pathway. Neuroscience 359:224\u2013247","journal-title":"Neuroscience"},{"issue":"3","key":"775_CR24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jnr.20162","volume":"77","author":"BE Fisher","year":"2004","unstructured":"Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul CK et al (2004) Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res 77(3):378\u2013390","journal-title":"J Neurosci Res"},{"issue":"1","key":"775_CR25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","volume":"2","author":"V Jackson-Lewis","year":"2007","unstructured":"Jackson-Lewis V, Przedborski S (2007) Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2(1):141\u2013151","journal-title":"Nat Protoc"},{"issue":"6","key":"775_CR26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3200\/JMBR.40.6.568-577","volume":"40","author":"TS Guillot","year":"2008","unstructured":"Guillot TS, Asress SA, Richardson JR, Glass JD, Miller GW (2008) Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis. J Mot Behav 40(6):568\u2013577","journal-title":"J Mot Behav"},{"key":"775_CR27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2011.02.003","volume":"1386","author":"BA Smith","year":"2011","unstructured":"Smith BA, Goldberg NR, Meshul CK (2011) Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. Brain Res 1386:70\u201380","journal-title":"Brain Res"},{"issue":"8","key":"775_CR28","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","volume":"19","author":"RJ Carter","year":"1999","unstructured":"Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP et al (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci Off J Soc Neurosci 19(8):3248\u20133257","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"1","key":"775_CR29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbr.2006.01.003","volume":"169","author":"P Klivenyi","year":"2006","unstructured":"Klivenyi P, Bende Z, Hartai Z, Penke Z, Nemeth H, Toldi J et al (2006) Behaviour changes in a transgenic model of Huntington's disease. Behav Brain Res 169(1):137\u2013141","journal-title":"Behav Brain Res"},{"issue":"2","key":"775_CR30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","volume":"141","author":"TY Pang","year":"2006","unstructured":"Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ (2006) Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. Neuroscience 141(2):569\u2013584","journal-title":"Neuroscience"},{"issue":"9","key":"775_CR31","doi-asserted-by":"crossref","first-page":"e75393","DOI":"10.1371\/journal.pone.0075393","volume":"8","author":"D Jansen","year":"2013","unstructured":"Jansen D, Zerbi V, Arnoldussen IA, Wiesmann M, Rijpma A, Fang XT et al (2013) Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AbetaPPswe-PS1dE9 mice. PLoS One 8(9):e75393","journal-title":"PLoS One"},{"issue":"1","key":"775_CR32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jnutbio.2014.08.002","volume":"26","author":"CI Janssen","year":"2015","unstructured":"Janssen CI, Zerbi V, Mutsaers MP, de Jong BS, Wiesmann M, Arnoldussen IA et al (2015) Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL\/6J mice. J Nutr Biochem 26(1):24\u201335","journal-title":"J Nutr Biochem"},{"key":"775_CR33","doi-asserted-by":"crossref","unstructured":"Carter RJ, Morton J, Dunnett SB (2001) Motor coordination and balance in rodents. Curr Protoc Neurosci 15:8.12:8.12.1\u20138.12.14","DOI":"10.1002\/0471142301.ns0812s15"},{"issue":"6","key":"775_CR34","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.neuropharm.2011.01.043","volume":"60","author":"YC Chung","year":"2011","unstructured":"Chung YC, Kim SR, Park JY, Chung ES, Park KW, Won SY et al (2011) Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation. Neuropharmacology 60(6):963\u2013974","journal-title":"Neuropharmacology"},{"key":"775_CR35","volume-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2001","unstructured":"Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates. Academic Press, San Diego"},{"issue":"7","key":"775_CR36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9(7):676\u2013682","journal-title":"Nat Methods"},{"key":"775_CR37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.nbd.2015.05.006","volume":"80","author":"NF Olde Loohuis","year":"2015","unstructured":"Olde Loohuis NF, Kole K, Glennon JC, Karel P, Van der Borg G, Van Gemert Y et al (2015) Elevated microRNA-181c and microRNA-30d levels in the enlarged amygdala of the valproic acid rat model of autism. Neurobiol Dis 80:42\u201353","journal-title":"Neurobiol Dis"},{"key":"775_CR38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/1471-2105-9-522","volume":"9","author":"WS Wu","year":"2008","unstructured":"Wu WS, Li WH (2008) Systematic identification of yeast cell cycle transcription factors using multiple data sources. BMC Bioinformatics 9:522","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"775_CR39","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s12035-015-9103-8","volume":"53","author":"CJHM Klemann","year":"2016","unstructured":"Klemann CJHM, Martens GJM, Poelmans G, Visser JE (2016) Validity of the MPTP-treated mouse as a model for Parkinson's disease. Mol Neurobiol 53(3):1625\u20131636","journal-title":"Mol Neurobiol"},{"issue":"4","key":"775_CR40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1176\/appi.ajp.2010.10070948","volume":"168","author":"G Poelmans","year":"2011","unstructured":"Poelmans G, Pauls DL, Buitelaar JK, Franke B (2011) Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder. Am J Psychiatry 168(4):365\u2013377","journal-title":"Am J Psychiatry"},{"key":"775_CR41","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1038\/tp.2013.48","volume":"3","author":"G Poelmans","year":"2013","unstructured":"Poelmans G, Franke B, Pauls DL, Glennon JC, Buitelaar JK (2013) AKAPs integrate genetic findings for autism spectrum disorders. Transl Psychiatry 3:e270","journal-title":"Transl Psychiatry"},{"key":"775_CR42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41531-017-0015-3","volume":"3","author":"C Klemann","year":"2017","unstructured":"Klemann C, Martens GJM, Sharma M, Martens MB, Isacson O, Gasser T et al (2017) Integrated molecular landscape of Parkinson's disease. NPJ Park Dis 3:14","journal-title":"NPJ Park Dis"},{"issue":"1","key":"775_CR43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nlm.2011.09.006","volume":"97","author":"K Wu","year":"2012","unstructured":"Wu K, Li S, Bodhinathan K, Meyers C, Chen W, Campbell-Thompson M et al (2012) Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology. Neurobiol Learn Mem 97(1):69\u201380","journal-title":"Neurobiol Learn Mem"},{"issue":"Database issue","key":"775_CR44","first-page":"D204","volume":"43","author":"UniProt","year":"2015","unstructured":"UniProt (2015) UniProt: a hub for protein information. Nucleic Acids Res 43(Database issue):D204\u2013D212","journal-title":"Nucleic Acids Res"},{"issue":"161","key":"775_CR45","first-page":"ra10","volume":"4","author":"CH Chen","year":"2011","unstructured":"Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW et al (2011) ER stress inhibits mTORC2 and Akt signaling through GSK-3beta-mediated phosphorylation of rictor. Sci Signal 4(161):ra10","journal-title":"Sci Signal"},{"issue":"24","key":"775_CR46","doi-asserted-by":"crossref","first-page":"14214","DOI":"10.1074\/jbc.271.24.14214","volume":"271","author":"AN Moore","year":"1996","unstructured":"Moore AN, Waxham MN, Dash PK (1996) Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex. J Biol Chem 271(24):14214\u201314220","journal-title":"J Biol Chem"},{"issue":"41","key":"775_CR47","doi-asserted-by":"crossref","first-page":"14389","DOI":"10.1523\/JNEUROSCI.3408-12.2012","volume":"32","author":"TL Beaumont","year":"2012","unstructured":"Beaumont TL, Yao B, Shah A, Kapatos G, Loeb JA (2012) Layer-specific CREB target gene induction in human neocortical epilepsy. J Neurosci Off J Soc Neurosci 32(41):14389\u201314401","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"2","key":"775_CR48","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0969-9961(03)00108-6","volume":"14","author":"E Rousselet","year":"2003","unstructured":"Rousselet E, Joubert C, Callebert J, Parain K, Tremblay L, Orieux G et al (2003) Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of parkinsonian toxin MPTP in mice. Neurobiol Dis 14(2):218\u2013228","journal-title":"Neurobiol Dis"},{"issue":"2","key":"775_CR49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/exnr.1994.1058","volume":"126","author":"U Muthane","year":"1994","unstructured":"Muthane U, Ramsay KA, Jiang H, Jackson-Lewis V, Donaldson D, Fernando S et al (1994) Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57\/bl and CD-1 mice. Exp Neurol 126(2):195\u2013204","journal-title":"Exp Neurol"},{"key":"775_CR50","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2016.01.048","volume":"616","author":"Z Guo","year":"2016","unstructured":"Guo Z, Xu S, Du N, Liu J, Huang Y, Han M (2016) Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson's disease: involvement of the dopamine system. Neurosci Lett 616:152\u2013159","journal-title":"Neurosci Lett"},{"key":"775_CR51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2016.04.015","volume":"621","author":"MS Shin","year":"2016","unstructured":"Shin MS, Jeong HY, An DI, Lee HY, Sung YH (2016) Treadmill exercise facilitates synaptic plasticity on dopaminergic neurons and fibers in the mouse model with Parkinson's disease. Neurosci Lett 621:28\u201333","journal-title":"Neurosci Lett"},{"issue":"5","key":"775_CR52","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1471-4159.2012.07837.x","volume":"122","author":"S Schumm","year":"2012","unstructured":"Schumm S, Sebban C, Cohen-Salmon C, Callebert J, Launay JM, Golmard JL et al (2012) Aging of the dopaminergic system and motor behavior in mice intoxicated with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurochem 122(5):1032\u20131046","journal-title":"J Neurochem"},{"key":"775_CR53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/neuro.24.003.2009","volume":"1","author":"G Patki","year":"2009","unstructured":"Patki G, Che Y, Lau YS (2009) Mitochondrial dysfunction in the striatum of aged chronic mouse model of Parkinson's disease. Front Aging Neurosci 1:3","journal-title":"Front Aging Neurosci"},{"issue":"8","key":"775_CR54","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1002\/stem.1708","volume":"32","author":"F L'Episcopo","year":"2014","unstructured":"L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Serapide MF et al (2014) Wnt\/beta-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease. Stem Cells 32(8):2147\u20132163","journal-title":"Stem Cells"},{"key":"775_CR55","first-page":"535","volume":"2016","author":"RL Hood","year":"1646","unstructured":"Hood RL, Liguore WA, Moore C, Pflibsen L, Meshul CK (1646) Exercise intervention increases spontaneous locomotion but fails to attenuate dopaminergic system loss in a progressive MPTP model in aged mice. Brain Res 2016:535\u2013542","journal-title":"Brain Res"},{"issue":"3\u20134","key":"775_CR56","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000113717","volume":"5","author":"M Sawada","year":"2008","unstructured":"Sawada M, Sawada H, Nagatsu T (2008) Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. Neurodegener Dis 5(3\u20134):254\u2013256","journal-title":"Neurodegener Dis"},{"issue":"2","key":"775_CR57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/jnc.13409","volume":"136","author":"AB Munoz-Manchado","year":"2016","unstructured":"Munoz-Manchado AB, Villadiego J, Romo-Madero S, Suarez-Luna N, Bermejo-Navas A, Rodriguez-Gomez JA et al (2016) Chronic and progressive Parkinson's disease MPTP model in adult and aged mice. J Neurochem 136(2):373\u2013387","journal-title":"J Neurochem"},{"issue":"4","key":"775_CR58","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jnr.20114","volume":"76","author":"MW Jakowec","year":"2004","unstructured":"Jakowec MW, Nixon K, Hogg E, McNeill T, Petzinger GM (2004) Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. J Neurosci Res 76(4):539\u2013550","journal-title":"J Neurosci Res"},{"issue":"5","key":"775_CR59","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","volume":"98","author":"M Vila","year":"2001","unstructured":"Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D et al (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98(5):2837\u20132842","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"775_CR60","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/1545968308328726","volume":"23","author":"AL Ridgel","year":"2009","unstructured":"Ridgel AL, Vitek JL, Alberts JL (2009) Forced, not voluntary, exercise improves motor function in Parkinson's disease patients. Neurorehabil Neural Repair 23(6):600\u2013608","journal-title":"Neurorehabil Neural Repair"},{"issue":"2","key":"775_CR61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbr.2010.05.009","volume":"213","author":"LM Gorton","year":"2010","unstructured":"Gorton LM, Vuckovic MG, Vertelkina N, Petzinger GM, Jakowec MW, Wood RI (2010) Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse. Behav Brain Res 213(2):253\u2013262","journal-title":"Behav Brain Res"},{"key":"775_CR62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.parkreldis.2016.01.015","volume":"24","author":"JL Alberts","year":"2016","unstructured":"Alberts JL, Phillips M, Lowe MJ, Frankemolle A, Thota A, Beall EB et al (2016) Cortical and motor responses to acute forced exercise in Parkinson's disease. Parkinsonism Relat Disord 24:56\u201362","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"775_CR63","doi-asserted-by":"crossref","first-page":"e100503","DOI":"10.1371\/journal.pone.0100503","volume":"9","author":"HF Shu","year":"2014","unstructured":"Shu HF, Yang T, Yu SX, Huang HD, Jiang LL, Gu JW et al (2014) Aerobic exercise for Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. PLoS One 9(7):e100503","journal-title":"PLoS One"},{"issue":"5","key":"775_CR64","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.0000000000000644","volume":"83","author":"EY Uc","year":"2014","unstructured":"Uc EY, Doerschug KC, Magnotta V, Dawson JD, Thomsen TR, Kline JN et al (2014) Phase I\/II randomized trial of aerobic exercise in Parkinson disease in a community setting. Neurology 83(5):413\u2013425","journal-title":"Neurology"},{"issue":"2","key":"775_CR65","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbr.2011.09.033","volume":"226","author":"DW Luchtman","year":"2012","unstructured":"Luchtman DW, Meng Q, Song C (2012) Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease. Behav Brain Res 226(2):386\u2013396","journal-title":"Behav Brain Res"},{"issue":"5","key":"775_CR66","doi-asserted-by":"crossref","first-page":"e64403","DOI":"10.1371\/journal.pone.0064403","volume":"8","author":"H Wang","year":"2013","unstructured":"Wang H, Liang X, Wang X, Luo D, Jia J, Wang X (2013) Electro-acupuncture stimulation improves spontaneous locomotor hyperactivity in MPTP intoxicated mice. PLoS One 8(5):e64403","journal-title":"PLoS One"},{"key":"775_CR67","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbr.2015.05.057","volume":"292","author":"SA Ferguson","year":"2015","unstructured":"Ferguson SA, Law CD, Sarkar S (2015) Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment. Behav Brain Res 292:68\u201378","journal-title":"Behav Brain Res"},{"issue":"4","key":"775_CR68","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0892-0362(90)90061-G","volume":"12","author":"VA Colotla","year":"1990","unstructured":"Colotla VA, Flores E, Oscos A, Meneses A, Tapia R (1990) Effects of MPTP on locomotor activity in mice. Neurotoxicol Teratol 12(4):405\u2013407","journal-title":"Neurotoxicol Teratol"},{"issue":"6","key":"775_CR69","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1023\/A:1020771211305","volume":"24","author":"LG Chia","year":"1999","unstructured":"Chia LG, Ni DR, Cheng FC, Ho YP, Kuo JS (1999) Intrastriatal injection of 5,7-dihydroxytryptamine decreased 5-HT levels in the striatum and suppressed locomotor activity in C57BL\/6 mice. Neurochem Res 24(6):719\u2013722","journal-title":"Neurochem Res"},{"issue":"1\u20132","key":"775_CR70","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.physbeh.2009.04.021","volume":"98","author":"DW Luchtman","year":"2009","unstructured":"Luchtman DW, Shao D, Song C (2009) Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease. Physiol Behav 98(1\u20132):130\u2013138","journal-title":"Physiol Behav"},{"issue":"7","key":"775_CR71","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.clinph.2007.03.010","volume":"118","author":"JE Visser","year":"2007","unstructured":"Visser JE, Voermans NC, Oude Nijhuis LB, van der Eijk M, Nijk R, Munneke M et al (2007) Quantification of trunk rotations during turning and walking in Parkinson's disease. Clin Neurophysiol 118(7):1602\u20131606","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"775_CR72","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.expneurol.2008.01.024","volume":"211","author":"SD Tabbal","year":"2008","unstructured":"Tabbal SD, Ushe M, Mink JW, Revilla FJ, Wernle AR, Hong M et al (2008) Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson disease. Exp Neurol 211(1):234\u2013242","journal-title":"Exp Neurol"},{"issue":"2","key":"775_CR73","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jnc.13214","volume":"135","author":"R Godoy","year":"2015","unstructured":"Godoy R, Noble S, Yoon K, Anisman H, Ekker M (2015) Chemogenetic ablation of dopaminergic neurons leads to transient locomotor impairments in zebrafish larvae. J Neurochem 135(2):249\u2013260","journal-title":"J Neurochem"},{"issue":"4","key":"775_CR74","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00004691-199407000-00004","volume":"11","author":"GE Alexander","year":"1994","unstructured":"Alexander GE (1994) Basal ganglia-thalamocortical circuits: their role in control of movements. J Clin Neurophysiol 11(4):420\u2013431","journal-title":"J Clin Neurophysiol"},{"issue":"8","key":"775_CR75","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00381-002-0604-1","volume":"18","author":"MT Herrero","year":"2002","unstructured":"Herrero MT, Barcia C, Navarro JM (2002) Functional anatomy of thalamus and basal ganglia. Childs Nerv Syst 18(8):386\u2013404","journal-title":"Childs Nerv Syst"},{"issue":"4","key":"775_CR76","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/1073858408317009","volume":"14","author":"R Cools","year":"2008","unstructured":"Cools R (2008) Role of dopamine in the motivational and cognitive control of behavior. Neuroscientist 14(4):381\u2013395","journal-title":"Neuroscientist"},{"key":"775_CR77","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnsys.2014.00016","volume":"8","author":"G Leisman","year":"2014","unstructured":"Leisman G, Braun-Benjamin O, Melillo R (2014) Cognitive-motor interactions of the basal ganglia in development. Front Syst Neurosci 8:16","journal-title":"Front Syst Neurosci"},{"key":"775_CR78","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuroscience.2014.10.008","volume":"282","author":"SN Haber","year":"2014","unstructured":"Haber SN (2014) The place of dopamine in the cortico-basal ganglia circuit. Neuroscience 282:248\u2013257","journal-title":"Neuroscience"},{"key":"775_CR79","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fneur.2014.00243","volume":"5","author":"H Morita","year":"2014","unstructured":"Morita H, Hass CJ, Moro E, Sudhyadhom A, Kumar R, Okun MS (2014) Pedunculopontine nucleus stimulation: where are we now and what needs to be done to move the field forward? Front Neurol 5:243","journal-title":"Front Neurol"},{"issue":"5","key":"775_CR80","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","volume":"8","author":"KR Chaudhuri","year":"2009","unstructured":"Chaudhuri KR, Schapira AH (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8(5):464\u2013474","journal-title":"Lancet Neurol"},{"issue":"4","key":"775_CR81","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.amjopharm.2010.08.002","volume":"8","author":"LD Wood","year":"2010","unstructured":"Wood LD, Neumiller JJ, Setter SM, Dobbins EK (2010) Clinical review of treatment options for select nonmotor symptoms of Parkinson's disease. Am J Geriatr Pharmacother 8(4):294\u2013315","journal-title":"Am J Geriatr Pharmacother"},{"issue":"Suppl 3","key":"775_CR82","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1002\/mds.23884","volume":"26","author":"K Seppi","year":"2011","unstructured":"Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R et al (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson's disease. Mov Disord 26(Suppl 3):S42\u2013S80","journal-title":"Mov Disord"},{"key":"775_CR83","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuropharm.2017.02.001","volume":"117","author":"S Kaska","year":"2017","unstructured":"Kaska S, Brunk R, Bali V, Kechner M, Mazei-Robison MS (2017) Deletion of Rictor in catecholaminergic neurons alters locomotor activity and ingestive behavior. Neuropharmacology 117:158\u2013170","journal-title":"Neuropharmacology"},{"issue":"3","key":"775_CR84","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/jcbfm.2012.183","volume":"33","author":"T Nozaki","year":"2013","unstructured":"Nozaki T, Sugiyama K, Yagi S, Yoshikawa E, Kanno T, Asakawa T et al (2013) Effect of subthalamic nucleus stimulation during exercise on the mesolimbocortical dopaminergic region in Parkinson's disease: a positron emission tomography study. J Cereb Blood Flow Metab 33(3):415\u2013421","journal-title":"J Cereb Blood Flow Metab"},{"issue":"Pt 5","key":"775_CR85","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/brain\/awr075","volume":"134","author":"PA MacDonald","year":"2011","unstructured":"MacDonald PA, MacDonald AA, Seergobin KN, Tamjeedi R, Ganjavi H, Provost JS et al (2011) The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI. Brain 134(Pt 5):1447\u20131463","journal-title":"Brain"},{"issue":"9","key":"775_CR86","doi-asserted-by":"crossref","first-page":"e0161935","DOI":"10.1371\/journal.pone.0161935","volume":"11","author":"W Yang","year":"2016","unstructured":"Yang W, Liu B, Huang B, Huang R, Wang L, Zhang Y et al (2016) Altered resting-state functional connectivity of the striatum in Parkinson's disease after levodopa administration. PLoS One 11(9):e0161935","journal-title":"PLoS One"},{"issue":"1","key":"775_CR87","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0091-3057(97)00581-9","volume":"60","author":"R Karler","year":"1998","unstructured":"Karler R, Calder LD, Thai DK, Bedingfield JB (1998) The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. Pharmacol Biochem Behav 60(1):237\u2013244","journal-title":"Pharmacol Biochem Behav"},{"issue":"1\u20133","key":"775_CR88","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2003.10.003","volume":"482","author":"M Matsumoto","year":"2003","unstructured":"Matsumoto M, Kanno M, Togashi H, Ueno K, Otani H, Mano Y et al (2003) Involvement of GABAA receptors in the regulation of the prefrontal cortex on dopamine release in the rat dorsolateral striatum. Eur J Pharmacol 482(1\u20133):177\u2013184","journal-title":"Eur J Pharmacol"},{"key":"775_CR89","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fncel.2015.00162","volume":"9","author":"D Jiao","year":"2015","unstructured":"Jiao D, Liu Y, Li X, Liu J, Zhao M (2015) The role of the GABA system in amphetamine-type stimulant use disorders. Front Cell Neurosci 9:162","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"775_CR90","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0006-8993(96)01170-5","volume":"749","author":"M Bubser","year":"1997","unstructured":"Bubser M, Feenstra MG, Erdtsieck-Ernste EB, Botterblom MH, Van Uum HF, Pool CW (1997) Modulatory role of catecholamines in the transsynaptic expression of c-fos in the rat medial prefrontal cortex induced by disinhibition of the mediodorsal thalamus: a study employing microdialysis and immunohistochemistry. Brain Res 749(2):214\u2013225","journal-title":"Brain Res"},{"issue":"2","key":"775_CR91","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nbd.2007.10.001","volume":"29","author":"B Picconi","year":"2008","unstructured":"Picconi B, Paille V, Ghiglieri V, Bagetta V, Barone I, Lindgren HS et al (2008) L-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation. Neurobiol Dis 29(2):327\u2013335","journal-title":"Neurobiol Dis"},{"issue":"9","key":"775_CR92","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrn2471","volume":"9","author":"P Jenner","year":"2008","unstructured":"Jenner P (2008) Molecular mechanisms of L-DOPA-induced dyskinesia. Nat Rev Neurosci 9(9):665\u2013677","journal-title":"Nat Rev Neurosci"},{"issue":"11","key":"775_CR93","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1474-4422(10)70218-0","volume":"9","author":"P Calabresi","year":"2010","unstructured":"Calabresi P, Di Filippo M, Ghiglieri V, Tambasco N, Picconi B (2010) Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap. Lancet Neurol 9(11):1106\u20131117","journal-title":"Lancet Neurol"},{"issue":"Pt 2","key":"775_CR94","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/brain\/111.2.299","volume":"111","author":"AM Gotham","year":"1988","unstructured":"Gotham AM, Brown RG, Marsden CD (1988) \u2018Frontal\u2019 cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. Brain 111(Pt 2):299\u2013321","journal-title":"Brain"},{"issue":"5","key":"775_CR95","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0028-3932(99)00103-7","volume":"38","author":"R Swainson","year":"2000","unstructured":"Swainson R, Rogers RD, Sahakian BJ, Summers BA, Polkey CE, Robbins TW (2000) Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. Neuropsychologia 38(5):596\u2013612","journal-title":"Neuropsychologia"},{"issue":"12","key":"775_CR96","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/cercor\/11.12.1136","volume":"11","author":"R Cools","year":"2001","unstructured":"Cools R, Barker RA, Sahakian BJ, Robbins TW (2001) Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. Cereb Cortex 11(12):1136\u20131143","journal-title":"Cereb Cortex"},{"issue":"1","key":"775_CR97","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/sj.npp.1301153","volume":"32","author":"R Cools","year":"2007","unstructured":"Cools R, Lewis SJ, Clark L, Barker RA, Robbins TW (2007) L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease. Neuropsychopharmacology 32(1):180\u2013189","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"775_CR98","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0028-3932(03)00117-9","volume":"41","author":"R Cools","year":"2003","unstructured":"Cools R, Barker RA, Sahakian BJ, Robbins TW (2003) L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease. Neuropsychologia 41(11):1431\u20131441","journal-title":"Neuropsychologia"},{"issue":"1","key":"775_CR99","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2012.02.006","volume":"230","author":"Y Kwak","year":"2012","unstructured":"Kwak Y, Muller ML, Bohnen NI, Dayalu P, Seidler RD (2012) L-DOPA changes ventral striatum recruitment during motor sequence learning in Parkinson's disease. Behav Brain Res 230(1):116\u2013124","journal-title":"Behav Brain Res"},{"issue":"1","key":"775_CR100","doi-asserted-by":"crossref","first-page":"e85747","DOI":"10.1371\/journal.pone.0085747","volume":"9","author":"C Nombela","year":"2014","unstructured":"Nombela C, Rittman T, Robbins TW, Rowe JB (2014) Multiple modes of impulsivity in Parkinson's disease. PLoS One 9(1):e85747","journal-title":"PLoS One"},{"key":"775_CR101","unstructured":"Calabresi P, Ghiglieri V, Mazzocchetti P, Corbelli I, Picconi B (2015) Levodopa-induced plasticity: a double-edged sword in Parkinson's disease? Philos Trans R Soc Lond B Biol Sci. 370(1672). pii: 20140184"},{"issue":"2","key":"775_CR102","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000341998","volume":"11","author":"AA Kehagia","year":"2013","unstructured":"Kehagia AA, Barker RA, Robbins TW (2013) Cognitive impairment in Parkinson's disease: the dual syndrome hypothesis. Neurodegener Dis 11(2):79\u201392","journal-title":"Neurodegener Dis"},{"issue":"14","key":"775_CR103","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/mds.25687","volume":"28","author":"DE Vaillancourt","year":"2013","unstructured":"Vaillancourt DE, Schonfeld D, Kwak Y, Bohnen NI, Seidler R (2013) Dopamine overdose hypothesis: evidence and clinical implications. Mov Disord 28(14):1920\u20131929","journal-title":"Mov Disord"},{"issue":"14","key":"775_CR104","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1007\/s00213-016-4322-x","volume":"233","author":"A Vo","year":"2016","unstructured":"Vo A, Seergobin KN, Morrow SA, MacDonald PA (2016) Levodopa impairs probabilistic reversal learning in healthy young adults. Psychopharmacology 233(14):2753\u20132763","journal-title":"Psychopharmacology"},{"issue":"3","key":"775_CR105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/mds.21346","volume":"22","author":"S Muhlack","year":"2007","unstructured":"Muhlack S, Welnic J, Woitalla D, Muller T (2007) Exercise improves efficacy of levodopa in patients with Parkinson's disease. Move Disord 22(3):427\u2013430","journal-title":"Move Disord"},{"issue":"4","key":"775_CR106","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3233\/NRE-2012-0758","volume":"30","author":"G Frazzitta","year":"2012","unstructured":"Frazzitta G, Bertotti G, Morelli M, Riboldazzi G, Pelosin E, Balbi P et al (2012) Rehabilitation improves dyskinesias in Parkinsonian patients: a pilot study comparing two different rehabilitative treatments. NeuroRehabilitation 30(4):295\u2013301","journal-title":"NeuroRehabilitation"},{"key":"775_CR107","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroscience.2013.03.039","volume":"243","author":"AS Aguiar Jr","year":"2013","unstructured":"Aguiar AS Jr, Moreira EL, Hoeller AA, Oliveira PA, Cordova FM, Glaser V et al (2013) Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience 243:46\u201353","journal-title":"Neuroscience"},{"issue":"4","key":"775_CR108","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3858\/emm.2011.43.4.026","volume":"43","author":"HJ Lee","year":"2011","unstructured":"Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ (2011) Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med 43(4):216\u2013222","journal-title":"Exp Mol Med"},{"key":"775_CR109","first-page":"186","volume":"2017","author":"Y Jang","year":"1655","unstructured":"Jang Y, Koo JH, Kwon I, Kang EB, Um HS, Soya H et al (1655) Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice. Brain Res 2017:186\u2013193","journal-title":"Brain Res"},{"key":"775_CR110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2017.05.016","volume":"356","author":"JH Koo","year":"2017","unstructured":"Koo JH, Jang YC, Hwang DJ, Um HS, Lee NH, Jung JH et al (2017) Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2\/MyD88\/NF-kappaB signaling pathway. Neuroscience 356:102\u2013113","journal-title":"Neuroscience"},{"key":"775_CR111","doi-asserted-by":"publisher","unstructured":"Koo JH, Cho JY (2017) Treadmill exercise attenuates alpha-synuclein levels by promoting mitochondrial function and autophagy possibly via SIRT1 in the chronic MPTP\/P-induced mouse model of Parkinson's disease. Neurotox Res. https:\/\/doi.org\/10.1007\/s12640-017-9770-5","DOI":"10.1007\/s12640-017-9770-5"},{"issue":"6","key":"775_CR112","doi-asserted-by":"crossref","first-page":"e513","DOI":"10.1371\/journal.pone.0000513","volume":"2","author":"MM Lima","year":"2007","unstructured":"Lima MM, Andersen ML, Reksidler AB, Vital MA, Tufik S (2007) The role of the substantia nigra pars compacta in regulating sleep patterns in rats. PLoS One 2(6):e513","journal-title":"PLoS One"},{"issue":"5","key":"775_CR113","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.smrv.2012.10.006","volume":"17","author":"MM Lima","year":"2013","unstructured":"Lima MM (2013) Sleep disturbances in Parkinson's disease: the contribution of dopamine in REM sleep regulation. Sleep Med Rev 17(5):367\u2013375","journal-title":"Sleep Med Rev"},{"issue":"3\u20134","key":"775_CR114","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neures.2012.09.005","volume":"74","author":"M Tanaka","year":"2012","unstructured":"Tanaka M, Yamaguchi E, Takahashi M, Hashimura K, Shibata T, Nakamura W et al (2012) Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neurosci Res 74(3\u20134):210\u2013215","journal-title":"Neurosci Res"},{"issue":"2","key":"775_CR115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12017-012-8214-x","volume":"15","author":"A Hayashi","year":"2013","unstructured":"Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H et al (2013) A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson's disease. NeuroMolecular Med 15(2):238\u2013251","journal-title":"NeuroMolecular Med"},{"issue":"3","key":"775_CR116","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/0004-282X20140228","volume":"73","author":"V Alatriste-Booth","year":"2015","unstructured":"Alatriste-Booth V, Rodriguez-Violante M, Camacho-Ordonez A, Cervantes-Arriaga A (2015) Prevalence and correlates of sleep disorders in Parkinson's disease: a polysomnographic study. Arq Neuropsiquiatr 73(3):241\u2013245","journal-title":"Arq Neuropsiquiatr"},{"issue":"3","key":"775_CR117","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.sleep.2013.10.016","volume":"15","author":"SJ Bolitho","year":"2014","unstructured":"Bolitho SJ, Naismith SL, Rajaratnam SM, Grunstein RR, Hodges JR, Terpening Z et al (2014) Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. Sleep Med 15(3):342\u2013347","journal-title":"Sleep Med"},{"issue":"9","key":"775_CR118","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1249\/MSS.0b013e318255cf4c","volume":"44","author":"G Wolff","year":"2012","unstructured":"Wolff G, Esser KA (2012) Scheduled exercise phase shifts the circadian clock in skeletal muscle. Med Sci Sports Exerc 44(9):1663\u20131670","journal-title":"Med Sci Sports Exerc"},{"issue":"23","key":"775_CR119","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1113\/jphysiol.2012.233676","volume":"590","author":"AM Schroeder","year":"2012","unstructured":"Schroeder AM, Truong D, Loh DH, Jordan MC, Roos KP, Colwell CS (2012) Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice. J Physiol 590(23):6213\u20136226","journal-title":"J Physiol"},{"issue":"23","key":"775_CR120","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1113\/jphysiol.2012.245308","volume":"590","author":"ME Harrington","year":"2012","unstructured":"Harrington ME (2012) Exercise strengthens circadian clocks. J Physiol 590(23):5929","journal-title":"J Physiol"},{"issue":"4","key":"775_CR121","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/jamaneurol.2013.6239","volume":"71","author":"A Videnovic","year":"2014","unstructured":"Videnovic A, Noble C, Reid KJ, Peng J, Turek FW, Marconi A et al (2014) Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol 71(4):463\u2013469","journal-title":"JAMA Neurol"},{"key":"775_CR122","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuropharm.2013.10.036","volume":"79","author":"J Bonaventura","year":"2014","unstructured":"Bonaventura J, Rico AJ, Moreno E, Sierra S, Sanchez M, Luquin N et al (2014) L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus. Neuropharmacology 79:90\u2013100","journal-title":"Neuropharmacology"},{"key":"775_CR123","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.expneurol.2013.12.021","volume":"253","author":"A Pinna","year":"2014","unstructured":"Pinna A, Bonaventura J, Farre D, Sanchez M, Simola N, Mallol J et al (2014) L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies. Exp Neurol 253:180\u2013191","journal-title":"Exp Neurol"},{"issue":"22","key":"775_CR124","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1523\/JNEUROSCI.22-22-10046.2002","volume":"22","author":"A Bilkei-Gorzo","year":"2002","unstructured":"Bilkei-Gorzo A, Racz I, Michel K, Zimmer A (2002) Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene. J Neurosci Off J Soc Neurosci 22(22):10046\u201310052","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"17","key":"775_CR125","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1097\/00001756-200312020-00015","volume":"14","author":"PB Sparling","year":"2003","unstructured":"Sparling PB, Giuffrida A, Piomelli D, Rosskopf L, Dietrich A (2003) Exercise activates the endocannabinoid system. Neuroreport 14(17):2209\u20132211","journal-title":"Neuroreport"},{"issue":"14","key":"775_CR126","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s00018-014-1575-6","volume":"71","author":"M Tantimonaco","year":"2014","unstructured":"Tantimonaco M, Ceci R, Sabatini S, Catani MV, Rossi A, Gasperi V et al (2014) Physical activity and the endocannabinoid system: an overview. Cell Mol Life Sci 71(14):2681\u20132698","journal-title":"Cell Mol Life Sci"},{"issue":"5 Suppl 1","key":"775_CR127","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1249\/01.mss.0000488168.52146.d8","volume":"48","author":"AG Brellenthin","year":"2016","unstructured":"Brellenthin AG, Crombie KM, Hillard CJ, Koltyn KF (2016) Endocannabinoid responses to exercise in low, moderate, and high active individuals: 3765 board #204 June 4, 8: 00 AM - 9: 30 AM. Med Sci Sports Exerc 48(5 Suppl 1):1052\u20131053","journal-title":"Med Sci Sports Exerc"},{"issue":"23","key":"775_CR128","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.2174\/138161208785740072","volume":"14","author":"M Filippo Di","year":"2008","unstructured":"Di Filippo M, Picconi B, Tozzi A, Ghiglieri V, Rossi A, Calabresi P (2008) The endocannabinoid system in Parkinson's disease. Curr Pharm Des 14(23):2337\u20132347","journal-title":"Curr Pharm Des"},{"issue":"5","key":"775_CR129","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1523\/JNEUROSCI.4082-10.2011","volume":"31","author":"A Tozzi","year":"2011","unstructured":"Tozzi A, de Iure A, Di Filippo M, Tantucci M, Costa C, Borsini F et al (2011) The distinct role of medium spiny neurons and cholinergic interneurons in the D(2)\/A(2)A receptor interaction in the striatum: Implications for Parkinson's disease. J Neurosci Off J Soc Neurosci 31(5):1850\u20131862","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"6","key":"775_CR130","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.brainresbull.2012.02.012","volume":"87","author":"S Farkas","year":"2012","unstructured":"Farkas S, Nagy K, Jia Z, Harkany T, Palkovits M, Donohou SR et al (2012) The decrease of dopamine D(2)\/D(3) receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB(1) cannabinoid receptors in Parkinson's disease: a preliminary autoradiographic study with the selective dopamine D(2)\/D(3) antagonist [(3)H]raclopride and the novel CB(1) inverse agonist [(1)(2)(5)I]SD7015. Brain Res Bull 87(6):504\u2013510","journal-title":"Brain Res Bull"},{"issue":"5","key":"775_CR131","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2174\/187152710793361568","volume":"9","author":"T Bisogno","year":"2010","unstructured":"Bisogno T, Di Marzo V (2010) Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders. CNS Neurol Disord Drug Targets 9(5):564\u2013573","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"2","key":"775_CR132","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/mds.23457","volume":"26","author":"V Pisani","year":"2011","unstructured":"Pisani V, Madeo G, Tassone A, Sciamanna G, Maccarrone M, Stanzione P et al (2011) Homeostatic changes of the endocannabinoid system in Parkinson's disease. Mov Disord 26(2):216\u2013222","journal-title":"Mov Disord"},{"issue":"2","key":"775_CR133","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0306-4522(94)00606-6","volume":"66","author":"AP Nisbet","year":"1995","unstructured":"Nisbet AP, Foster OJ, Kingsbury A, Eve DJ, Daniel SE, Marsden CD et al (1995) Preproenkephalin and preprotachykinin messenger RNA expression in normal human basal ganglia and in Parkinson's disease. Neuroscience 66(2):361\u2013376","journal-title":"Neuroscience"},{"issue":"2","key":"775_CR134","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/jnen\/61.2.186","volume":"61","author":"F Calon","year":"2002","unstructured":"Calon F, Birdi S, Rajput AH, Hornykiewicz O, Bedard PJ, Di Paolo T (2002) Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias. J Neuropathol Exp Neurol 61(2):186\u2013196","journal-title":"J Neuropathol Exp Neurol"},{"issue":"10","key":"775_CR135","doi-asserted-by":"crossref","first-page":"M111.009308","DOI":"10.1074\/mcp.M111.009308","volume":"10","author":"J Hanrieder","year":"2011","unstructured":"Hanrieder J, Ljungdahl A, Falth M, Mammo SE, Bergquist J, Andersson M (2011) L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry. Mol Cell Proteomics 10(10):M111.009308","journal-title":"Mol Cell Proteomics"},{"issue":"26","key":"775_CR136","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1523\/JNEUROSCI.0852-07.2007","volume":"27","author":"E Santini","year":"2007","unstructured":"Santini E, Valjent E, Usiello A, Carta M, Borgkvist A, Girault JA et al (2007) Critical involvement of cAMP\/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. J Neurosci Off J Soc Neurosci 27(26):6995\u20137005","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"1","key":"775_CR137","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1124\/pr.111.005678","volume":"65","author":"P Huot","year":"2013","unstructured":"Huot P, Johnston TH, Koprich JB, Fox SH, Brotchie JM (2013) The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease. Pharmacol Rev 65(1):171\u2013222","journal-title":"Pharmacol Rev"},{"issue":"8","key":"775_CR138","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/syn.21740","volume":"68","author":"Y Wang","year":"2014","unstructured":"Wang Y, Zhang QJ, Wang HS, Wang T, Liu J (2014) Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia. Synapse 68(8):332\u2013343","journal-title":"Synapse"},{"issue":"5","key":"775_CR139","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1523\/JNEUROSCI.3008-04.2005","volume":"25","author":"F Berrendero","year":"2005","unstructured":"Berrendero F, Mendizabal V, Robledo P, Galeote L, Bilkei-Gorzo A, Zimmer A et al (2005) Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene. J Neurosci Off J Soc Neurosci 25(5):1103\u20131112","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"3","key":"775_CR140","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1172\/JCI30413","volume":"117","author":"A Meyer-Lindenberg","year":"2007","unstructured":"Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH et al (2007) Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest 117(3):672\u2013682","journal-title":"J Clin Invest"},{"issue":"7","key":"775_CR141","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00702-009-0238-5","volume":"116","author":"H Kolsch","year":"2009","unstructured":"Kolsch H, Wagner M, Bilkei-Gorzo A, Toliat MR, Pentzek M, Fuchs A et al (2009) Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. J Neural Transm 116(7):897\u2013903","journal-title":"J Neural Transm"},{"issue":"1","key":"775_CR142","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/npp.2010.96","volume":"36","author":"MJ Frank","year":"2011","unstructured":"Frank MJ, Fossella JA (2011) Neurogenetics and pharmacology of learning, motivation, and cognition. Neuropsychopharmacology 36(1):133\u2013152","journal-title":"Neuropsychopharmacology"},{"key":"775_CR143","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnbeh.2011.00057","volume":"5","author":"C Zanettini","year":"2011","unstructured":"Zanettini C, Panlilio LV, Alicki M, Goldberg SR, Haller J, Yasar S (2011) Effects of endocannabinoid system modulation on cognitive and emotional behavior. Front Behav Neurosci 5:57","journal-title":"Front Behav Neurosci"},{"key":"775_CR144","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fnbeh.2015.00172","volume":"9","author":"M Votinov","year":"2015","unstructured":"Votinov M, Pripfl J, Windischberger C, Moser E, Sailer U, Lamm C (2015) A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning. Front Behav Neurosci 9:172","journal-title":"Front Behav Neurosci"},{"issue":"8","key":"775_CR145","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","volume":"27","author":"P Voorn","year":"2004","unstructured":"Voorn P, Vanderschuren LJ, Groenewegen HJ, Robbins TW, Pennartz CM (2004) Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci 27(8):468\u2013474","journal-title":"Trends Neurosci"},{"issue":"1","key":"775_CR146","doi-asserted-by":"crossref","first-page":"7","DOI":"10.31887\/DCNS.2016.18.1\/shaber","volume":"18","author":"SN Haber","year":"2016","unstructured":"Haber SN (2016) Corticostriatal circuitry. Dialogues Clin Neurosci 18(1):7\u201321","journal-title":"Dialogues Clin Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-017-0775-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0775-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0775-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T01:53:52Z","timestamp":1603072432000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-017-0775-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":146,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["775"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0775-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]}}}