{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:23:06Z","timestamp":1790760186261,"version":"4.1.0"},"reference-count":279,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009044","name":"Technische Universit\u00e4t Kaiserslautern","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s12035-017-0806-x","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T02:47:26Z","timestamp":1509072446000},"page":"5809-5829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Trafficking in Alzheimer\u2019s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-5556","authenticated-orcid":false,"given":"Simone","family":"Eggert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Hermey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"issue":"6","key":"806_CR1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","volume":"148","author":"Y Huang","year":"2012","unstructured":"Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148(6):1204\u20131222","journal-title":"Cell"},{"issue":"4","key":"806_CR2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","volume":"120","author":"RE Tanzi","year":"2005","unstructured":"Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer\u2019s disease amyloid hypothesis: a genetic perspective. Cell 120(4):545\u2013555","journal-title":"Cell"},{"issue":"1","key":"806_CR3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuron.2006.09.001","volume":"52","author":"SA Small","year":"2006","unstructured":"Small SA, Gandy S (2006) Sorting through the cell biology of Alzheimer\u2019s disease: intracellular pathways to pathogenesis. Neuron 52(1):15\u201331","journal-title":"Neuron"},{"issue":"2","key":"806_CR4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.expneurol.2003.10.011","volume":"185","author":"GD King","year":"2004","unstructured":"King GD, Scott Turner R (2004) Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer\u2019s disease risk? Exp Neurol 185(2):208\u2013219","journal-title":"Exp Neurol"},{"issue":"12","key":"806_CR5","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/jnr.21239","volume":"85","author":"S Back","year":"2007","unstructured":"Back S et al (2007) Beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res 85(12):2580\u20132590","journal-title":"J Neurosci Res"},{"issue":"46","key":"806_CR6","doi-asserted-by":"crossref","first-page":"14534","DOI":"10.1523\/JNEUROSCI.1546-09.2009","volume":"29","author":"A Szodorai","year":"2009","unstructured":"Szodorai A et al (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci: Off J Soc Neurosci 29(46):14534\u201314544","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"17","key":"806_CR7","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1038\/emboj.2010.167","volume":"29","author":"PH Kuhn","year":"2010","unstructured":"Kuhn PH et al (2010) ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J 29(17):3020\u20133032","journal-title":"EMBO J"},{"issue":"7","key":"806_CR8","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1073\/pnas.96.7.3922","volume":"96","author":"S Lammich","year":"1999","unstructured":"Lammich S et al (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A 96(7):3922\u20133927","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 3","key":"806_CR9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1042\/bj3570787","volume":"357","author":"BE Slack","year":"2001","unstructured":"Slack BE, Ma LK, Seah CC (2001) Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme. Biochem J 357(Pt 3):787\u2013794","journal-title":"Biochem J"},{"issue":"1","key":"806_CR10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1471-4159.2010.07081.x","volume":"116","author":"SF Lichtenthaler","year":"2011","unstructured":"Lichtenthaler SF (2011) Alpha-secretase in Alzheimer\u2019s disease: molecular identity, regulation and therapeutic potential. J Neurochem 116(1):10\u201321","journal-title":"J Neurochem"},{"issue":"5","key":"806_CR11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1471-4159.2011.07248.x","volume":"117","author":"SF Lichtenthaler","year":"2011","unstructured":"Lichtenthaler SF, Haass C, Steiner H (2011) Regulated intramembrane proteolysis\u2014lessons from amyloid precursor protein processing. J Neurochem 117(5):779\u2013796","journal-title":"J Neurochem"},{"issue":"49","key":"806_CR12","doi-asserted-by":"crossref","first-page":"50647","DOI":"10.1074\/jbc.C400473200","volume":"279","author":"G Zhao","year":"2004","unstructured":"Zhao G et al (2004) Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J Biol Chem 279(49):50647\u201350650","journal-title":"J Biol Chem"},{"issue":"8","key":"806_CR13","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1021\/bi015794o","volume":"41","author":"A Weidemann","year":"2002","unstructured":"Weidemann A et al (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with notch processing. Biochemistry 41(8):2825\u20132835","journal-title":"Biochemistry"},{"issue":"9","key":"806_CR14","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/embo-reports\/kve180","volume":"2","author":"M Sastre","year":"2001","unstructured":"Sastre M et al (2001) Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of notch. EMBO Rep 2(9):835\u2013841","journal-title":"EMBO Rep"},{"issue":"38","key":"806_CR15","doi-asserted-by":"crossref","first-page":"35235","DOI":"10.1074\/jbc.C100357200","volume":"276","author":"Y Gu","year":"2001","unstructured":"Gu Y et al (2001) Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of notch. J Biol Chem 276(38):35235\u201335238","journal-title":"J Biol Chem"},{"issue":"5","key":"806_CR16","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1016\/S0021-9258(18)53650-4","volume":"268","author":"C Haass","year":"1993","unstructured":"Haass C et al (1993) Beta-amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem 268(5):3021\u20133024","journal-title":"J Biol Chem"},{"issue":"5440","key":"806_CR17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R et al (1999) Beta-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286(5440):735\u2013741","journal-title":"Science"},{"issue":"41","key":"806_CR18","doi-asserted-by":"crossref","first-page":"12787","DOI":"10.1523\/JNEUROSCI.3657-09.2009","volume":"29","author":"R Vassar","year":"2009","unstructured":"Vassar R et al (2009) The beta-secretase enzyme BACE in health and Alzheimer\u2019s disease: regulation, cell biology, function, and therapeutic potential. J Neurosci 29(41):12787\u201312794","journal-title":"J Neurosci"},{"issue":"6393","key":"806_CR19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","volume":"359","author":"C Haass","year":"1992","unstructured":"Haass C et al (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359(6393):322\u2013325","journal-title":"Nature"},{"issue":"2","key":"806_CR20","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1523\/JNEUROSCI.1575-04.2005","volume":"25","author":"Y Qi-Takahara","year":"2005","unstructured":"Qi-Takahara Y et al (2005) Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci Off J Soc Neurosci 25(2):436\u2013445","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"12","key":"806_CR21","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1074\/jbc.272.12.7977","volume":"272","author":"W Xia","year":"1997","unstructured":"Xia W et al (1997) Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 272(12):7977\u20137982","journal-title":"J Biol Chem"},{"issue":"5580","key":"806_CR22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297(5580):353\u2013356","journal-title":"Science"},{"issue":"2","key":"806_CR23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2007.10.012","volume":"131","author":"DJ Selkoe","year":"2007","unstructured":"Selkoe DJ, Wolfe MS (2007) Presenilin: running with scissors in the membrane. Cell 131(2):215\u2013221","journal-title":"Cell"},{"issue":"2","key":"806_CR24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/alzrt107","volume":"4","author":"S Weggen","year":"2012","unstructured":"Weggen S, Beher D (2012) Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer\u2019s disease. Alzheimers Res Ther 4(2):9","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"806_CR25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neurobiolaging.2004.08.002","volume":"26","author":"M Duering","year":"2005","unstructured":"Duering M et al (2005) Mean age of onset in familial Alzheimer\u2019s disease is determined by amyloid beta 42. Neurobiol Aging 26(6):785\u2013788","journal-title":"Neurobiol Aging"},{"issue":"41","key":"806_CR26","doi-asserted-by":"crossref","first-page":"13042","DOI":"10.1523\/JNEUROSCI.2362-09.2009","volume":"29","author":"M Takami","year":"2009","unstructured":"Takami M et al (2009) Gamma-secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J Neurosci: Off J Soc Neurosci 29(41):13042\u201313052","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"37","key":"806_CR27","doi-asserted-by":"crossref","first-page":"19235","DOI":"10.1074\/jbc.R116.746032","volume":"291","author":"RJ Andrew","year":"2016","unstructured":"Andrew RJ et al (2016) A Greek tragedy: the growing complexity of Alzheimer amyloid precursor protein proteolysis. J Biol Chem 291(37):19235\u201319244","journal-title":"J Biol Chem"},{"issue":"7573","key":"806_CR28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature14864","volume":"526","author":"M Willem","year":"2015","unstructured":"Willem M et al (2015) Eta-secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526(7573):443\u2013447","journal-title":"Nature"},{"issue":"11","key":"806_CR29","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/cr.2015.125","volume":"25","author":"SH Tyan","year":"2015","unstructured":"Tyan SH, Koo EH (2015) New tricks from an old dog: another synaptotoxic fragment from APP. Cell Res 25(11):1185\u20131186","journal-title":"Cell Res"},{"issue":"3","key":"806_CR30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/jb\/mvj054","volume":"139","author":"M Ahmad","year":"2006","unstructured":"Ahmad M et al (2006) Cleavage of amyloid-beta precursor protein (APP) by membrane-type matrix metalloproteinases. J Biochem 139(3):517\u2013526","journal-title":"J Biochem"},{"key":"806_CR31","first-page":"163","volume":"9","author":"K Baranger","year":"2016","unstructured":"Baranger K et al (2016) MT5-MMP promotes Alzheimer\u2019s pathogenesis in the frontal cortex of 5xFAD mice and APP trafficking in vitro. Front Mol Neurosci 9:163","journal-title":"Front Mol Neurosci"},{"issue":"7","key":"806_CR32","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","volume":"2","author":"VW Yong","year":"2001","unstructured":"Yong VW et al (2001) Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2(7):502\u2013511","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"806_CR33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","volume":"92","author":"R Visse","year":"2003","unstructured":"Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92(8):827\u2013839","journal-title":"Circ Res"},{"issue":"38","key":"806_CR34","doi-asserted-by":"crossref","first-page":"35953","DOI":"10.1074\/jbc.M103680200","volume":"276","author":"X Wang","year":"2001","unstructured":"Wang X, Pei D (2001) Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation. J Biol Chem 276(38):35953\u201335960","journal-title":"J Biol Chem"},{"issue":"5","key":"806_CR35","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1046\/j.0953-816x.2001.01462.x","volume":"13","author":"Y Sekine-Aizawa","year":"2001","unstructured":"Sekine-Aizawa Y et al (2001) Matrix metalloproteinase (MMP) system in brain: Identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci 13(5):935\u2013948","journal-title":"Eur J Neurosci"},{"key":"806_CR36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1101\/SQB.1996.061.01.058","volume":"61","author":"PJ Tienari","year":"1996","unstructured":"Tienari PJ et al (1996) Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer\u2019s disease. Cold Spring Harb Symp Quant Biol 61:575\u2013585","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"806_CR37","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1038\/ncomms9762","volume":"6","author":"Z Zhang","year":"2015","unstructured":"Zhang Z et al (2015) Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer\u2019s disease. Nat Commun 6:8762","journal-title":"Nat Commun"},{"key":"806_CR38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-016-0084-5","volume":"11","author":"C Schonherr","year":"2016","unstructured":"Schonherr C et al (2016) Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site. Mol Neurodegener 11:19","journal-title":"Mol Neurodegener"},{"issue":"1","key":"806_CR39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/BJ20141417","volume":"470","author":"F Jackle","year":"2015","unstructured":"Jackle F et al (2015) Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding. Biochem J 470(1):91\u2013103","journal-title":"Biochem J"},{"issue":"40","key":"806_CR40","doi-asserted-by":"crossref","first-page":"16131","DOI":"10.1073\/pnas.1211076109","volume":"109","author":"JL Arolas","year":"2012","unstructured":"Arolas JL et al (2012) Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane. Proc Natl Acad Sci U S A 109(40):16131\u201316136","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"40","key":"806_CR41","doi-asserted-by":"crossref","first-page":"33304","DOI":"10.1074\/jbc.M112.395608","volume":"287","author":"J Bien","year":"2012","unstructured":"Bien J et al (2012) The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species. J Biol Chem 287(40):33304\u201333313","journal-title":"J Biol Chem"},{"issue":"31","key":"806_CR42","doi-asserted-by":"crossref","first-page":"27741","DOI":"10.1074\/jbc.M111.252718","volume":"286","author":"T Jefferson","year":"2011","unstructured":"Jefferson T et al (2011) Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. J Biol Chem 286(31):27741\u201327750","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cell.2016.05.020","volume":"166","author":"R Sannerud","year":"2016","unstructured":"Sannerud R et al (2016) Restricted location of PSEN2\/gamma-secretase determines substrate specificity and generates an intracellular Abeta pool. Cell 166(1):193\u2013208","journal-title":"Cell"},{"issue":"24","key":"806_CR44","doi-asserted-by":"crossref","first-page":"12821","DOI":"10.1074\/jbc.M115.708297","volume":"291","author":"X Meckler","year":"2016","unstructured":"Meckler X, Checler F (2016) Presenilin 1 and presenilin 2 target gamma-secretase complexes to distinct cellular compartments. J Biol Chem 291(24):12821\u201312837","journal-title":"J Biol Chem"},{"issue":"4","key":"806_CR45","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1600-0854.2006.00396.x","volume":"7","author":"C Kaether","year":"2006","unstructured":"Kaether C et al (2006) Amyloid precursor protein and notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 7(4):408\u2013415","journal-title":"Traffic"},{"issue":"4","key":"806_CR46","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1074\/jbc.275.4.2568","volume":"275","author":"DM Skovronsky","year":"2000","unstructured":"Skovronsky DM et al (2000) Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J Biol Chem 275(4):2568\u20132575","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(03)00067-4","volume":"61","author":"A Rocchi","year":"2003","unstructured":"Rocchi A et al (2003) Causative and susceptibility genes for Alzheimer\u2019s disease: a review. Brain Res Bull 61(1):1\u201324","journal-title":"Brain Res Bull"},{"issue":"5","key":"806_CR48","doi-asserted-by":"crossref","first-page":"a006270","DOI":"10.1101\/cshperspect.a006270","volume":"2","author":"C Haass","year":"2012","unstructured":"Haass C et al (2012) Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2(5):a006270","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"5 Pt 2","key":"806_CR49","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1523\/JNEUROSCI.14-05-03122.1994","volume":"14","author":"GL Caporaso","year":"1994","unstructured":"Caporaso GL et al (1994) Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta\/A4 amyloid precursor protein. J Neurosci: Off J Soc Neurosci 14(5 Pt 2):3122\u20133138","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"3\u20134","key":"806_CR50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-328X(92)90109-O","volume":"15","author":"G Palacios","year":"1992","unstructured":"Palacios G et al (1992) Beta-amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons. Brain Res Mol Brain Res 15(3\u20134):195\u2013206","journal-title":"Brain Res Mol Brain Res"},{"issue":"4","key":"806_CR51","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1074\/jbc.M111.315051","volume":"287","author":"Q Guo","year":"2012","unstructured":"Guo Q et al (2012) Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem 287(4):2437\u20132445","journal-title":"J Biol Chem"},{"issue":"3","key":"806_CR52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuron.2013.05.035","volume":"79","author":"U Das","year":"2013","unstructured":"Das U et al (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 79(3):447\u2013460","journal-title":"Neuron"},{"issue":"Pt 13","key":"806_CR53","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1242\/jcs.125393","volume":"126","author":"TE Willnow","year":"2013","unstructured":"Willnow TE, Andersen OM (2013) Sorting receptor SORLA\u2014a trafficking path to avoid Alzheimer disease. J Cell Sci 126(Pt 13):2751\u20132760","journal-title":"J Cell Sci"},{"issue":"6378","key":"806_CR54","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/357500a0","volume":"357","author":"C Haass","year":"1992","unstructured":"Haass C et al (1992) Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357(6378):500\u2013503","journal-title":"Nature"},{"key":"806_CR55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.1992.tb27480.x","volume":"674","author":"GM Cole","year":"1992","unstructured":"Cole GM et al (1992) An endosomal-lysosomal pathway for degradation of amyloid precursor protein. Ann N Y Acad Sci 674:103\u2013117","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"806_CR56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1083\/jcb.200207113","volume":"160","author":"R Ehehalt","year":"2003","unstructured":"Ehehalt R et al (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160(1):113\u2013123","journal-title":"J Cell Biol"},{"issue":"11","key":"806_CR57","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1523\/JNEUROSCI.5345-07.2008","volume":"28","author":"A Schneider","year":"2008","unstructured":"Schneider A et al (2008) Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J Neurosci 28(11):2874\u20132882","journal-title":"J Neurosci"},{"issue":"8","key":"806_CR58","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1074\/jbc.270.8.3565","volume":"270","author":"A Lai","year":"1995","unstructured":"Lai A, Sisodia SS, Trowbridge IS (1995) Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. J Biol Chem 270(8):3565\u20133573","journal-title":"J Biol Chem"},{"issue":"4","key":"806_CR59","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.87.4.1561","volume":"87","author":"EH Koo","year":"1990","unstructured":"Koo EH et al (1990) Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A 87(4):1561\u20131565","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"806_CR60","doi-asserted-by":"crossref","first-page":"17268","DOI":"10.1074\/jbc.270.29.17268","volume":"270","author":"A Amaratunga","year":"1995","unstructured":"Amaratunga A, Fine RE (1995) Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve. J Biol Chem 270(29):17268\u201317272","journal-title":"J Biol Chem"},{"issue":"2","key":"806_CR61","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1471-4159.1993.tb02147.x","volume":"61","author":"PJ Morin","year":"1993","unstructured":"Morin PJ et al (1993) Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. J Neurochem 61(2):464\u2013473","journal-title":"J Neurochem"},{"issue":"4","key":"806_CR62","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1091\/mbc.11.4.1213","volume":"11","author":"C Kaether","year":"2000","unstructured":"Kaether C, Skehel P, Dotti CG (2000) Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol Biol Cell 11(4):1213\u20131224","journal-title":"Mol Biol Cell"},{"issue":"2","key":"806_CR63","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1083\/jcb.129.2.431","volume":"129","author":"T Yamazaki","year":"1995","unstructured":"Yamazaki T, Selkoe DJ, Koo EH (1995) Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J Cell Biol 129(2):431\u2013442","journal-title":"J Cell Biol"},{"issue":"7","key":"806_CR64","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1523\/JNEUROSCI.13-07-03112.1993","volume":"13","author":"A Ferreira","year":"1993","unstructured":"Ferreira A, Caceres A, Kosik KS (1993) Intraneuronal compartments of the amyloid precursor protein. J Neurosci 13(7):3112\u20133123","journal-title":"J Neurosci"},{"issue":"9","key":"806_CR65","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1021\/bi00409a043","volume":"27","author":"GS Bloom","year":"1988","unstructured":"Bloom GS et al (1988) Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide. Biochemistry 27(9):3409\u20133416","journal-title":"Biochemistry"},{"issue":"15","key":"806_CR66","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1021\/bi702445j","volume":"47","author":"SR DeBoer","year":"2008","unstructured":"DeBoer SR et al (2008) Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry 47(15):4535\u20134543","journal-title":"Biochemistry"},{"issue":"Pt 11","key":"806_CR67","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1242\/jcs.113.11.2047","volume":"113","author":"FK Gyoeva","year":"2000","unstructured":"Gyoeva FK, Bybikova EM, Minin AA (2000) An isoform of kinesin light chain specific for the Golgi complex. J Cell Sci 113(Pt 11):2047\u20132054","journal-title":"J Cell Sci"},{"issue":"22","key":"806_CR68","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1073\/pnas.88.22.10114","volume":"88","author":"JL Cyr","year":"1991","unstructured":"Cyr JL et al (1991) Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing. Proc Natl Acad Sci U S A 88(22):10114\u201310118","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"806_CR69","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1091\/mbc.9.2.333","volume":"9","author":"A Khodjakov","year":"1998","unstructured":"Khodjakov A et al (1998) A specific light chain of kinesin associates with mitochondria in cultured cells. Mol Biol Cell 9(2):333\u2013343","journal-title":"Mol Biol Cell"},{"issue":"Pt 3","key":"806_CR70","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.brainresbull.2016.06.009","volume":"126","author":"G Morfini","year":"2016","unstructured":"Morfini G et al (2016) Conventional kinesin: biochemical heterogeneity and functional implications in health and disease. Brain Res Bull 126(Pt 3):347\u2013353","journal-title":"Brain Res Bull"},{"issue":"9","key":"806_CR71","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1523\/JNEUROSCI.3089-04.2005","volume":"25","author":"O Lazarov","year":"2005","unstructured":"Lazarov O et al (2005) Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci 25(9):2386\u20132395","journal-title":"J Neurosci"},{"issue":"40","key":"806_CR72","doi-asserted-by":"crossref","first-page":"38601","DOI":"10.1074\/jbc.M304379200","volume":"278","author":"S Matsuda","year":"2003","unstructured":"Matsuda S, Matsuda Y, D'Adamio L (2003) Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem 278(40):38601\u201338606","journal-title":"J Biol Chem"},{"issue":"25","key":"806_CR73","doi-asserted-by":"crossref","first-page":"22946","DOI":"10.1074\/jbc.M212160200","volume":"278","author":"H Inomata","year":"2003","unstructured":"Inomata H et al (2003) A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278(25):22946\u201322955","journal-title":"J Biol Chem"},{"issue":"22","key":"806_CR74","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1091\/mbc.e14-06-1111","volume":"25","author":"K Chiba","year":"2014","unstructured":"Chiba K et al (2014) Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Mol Biol Cell 25(22):3569\u20133580","journal-title":"Mol Biol Cell"},{"issue":"3","key":"806_CR75","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.201302078","volume":"202","author":"MM Fu","year":"2013","unstructured":"Fu MM, Holzbaur EL (2013) JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J Cell Biol 202(3):495\u2013508","journal-title":"J Cell Biol"},{"issue":"22","key":"806_CR76","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1093\/hmg\/ddt313","volume":"22","author":"A Vagnoni","year":"2013","unstructured":"Vagnoni A et al (2013) Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or abeta production. Hum Mol Genet 22(22):4646\u20134652","journal-title":"Hum Mol Genet"},{"issue":"4","key":"806_CR77","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1460-9568.2007.05341.x","volume":"25","author":"P Rusu","year":"2007","unstructured":"Rusu P et al (2007) Axonal accumulation of synaptic markers in APP transgenic drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity. Eur J Neurosci 25(4):1079\u20131086","journal-title":"Eur J Neurosci"},{"issue":"11","key":"806_CR78","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1515\/bc.2010.129","volume":"391","author":"M Dieckmann","year":"2010","unstructured":"Dieckmann M, Dietrich MF, Herz J (2010) Lipoprotein receptors\u2014an evolutionarily ancient multifunctional receptor family. Biol Chem 391(11):1341\u20131363","journal-title":"Biol Chem"},{"issue":"6","key":"806_CR79","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0962-8924(02)02282-1","volume":"12","author":"A Nykjaer","year":"2002","unstructured":"Nykjaer A, Willnow TE (2002) The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol 12(6):273\u2013280","journal-title":"Trends Cell Biol"},{"key":"806_CR80","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fnmol.2017.00054","volume":"10","author":"T Pohlkamp","year":"2017","unstructured":"Pohlkamp T, Wasser CR, Herz J (2017) Functional roles of the interaction of APP and lipoprotein receptors. Front Mol Neurosci 10:54","journal-title":"Front Mol Neurosci"},{"issue":"4746","key":"806_CR81","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","volume":"232","author":"MS Brown","year":"1986","unstructured":"Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232(4746):34\u201347","journal-title":"Science"},{"issue":"176","key":"806_CR82","first-page":"PE12","volume":"2003","author":"P May","year":"2003","unstructured":"May P, Bock HH, Herz J (2003) Integration of endocytosis and signal transduction by lipoprotein receptors. Sci STKE 2003(176):PE12","journal-title":"Sci STKE"},{"issue":"3\u20134","key":"806_CR83","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00221-011-2876-8","volume":"217","author":"T Wagner","year":"2012","unstructured":"Wagner T, Pietrzik CU (2012) The role of lipoprotein receptors on the physiological function of APP. Exp Brain Res 217(3\u20134):377\u2013387","journal-title":"Exp Brain Res"},{"issue":"4","key":"806_CR84","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0092-8674(94)90219-4","volume":"77","author":"EG Marcusson","year":"1994","unstructured":"Marcusson EG et al (1994) The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 77(4):579\u2013586","journal-title":"Cell"},{"issue":"49","key":"806_CR85","doi-asserted-by":"crossref","first-page":"31379","DOI":"10.1074\/jbc.271.49.31379","volume":"271","author":"L Jacobsen","year":"1996","unstructured":"Jacobsen L et al (1996) Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem 271(49):31379\u201331383","journal-title":"J Biol Chem"},{"issue":"40","key":"806_CR86","doi-asserted-by":"crossref","first-page":"24761","DOI":"10.1074\/jbc.271.40.24761","volume":"271","author":"H Yamazaki","year":"1996","unstructured":"Yamazaki H et al (1996) Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J Biol Chem 271(40):24761\u201324768","journal-title":"J Biol Chem"},{"issue":"16","key":"806_CR87","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1007\/s00018-009-0043-1","volume":"66","author":"G Hermey","year":"2009","unstructured":"Hermey G (2009) The Vps10p-domain receptor family. Cell Mol Life Sci: CMLS 66(16):2677\u20132689","journal-title":"Cell Mol Life Sci: CMLS"},{"issue":"5","key":"806_CR88","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0969-2126(00)00034-4","volume":"2","author":"ID Campbell","year":"1994","unstructured":"Campbell ID, Spitzfaden C (1994) Building proteins with fibronectin type III modules. Structure 2(5):333\u2013337","journal-title":"Structure"},{"issue":"1","key":"806_CR89","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nsmb.1543","volume":"16","author":"EM Quistgaard","year":"2009","unstructured":"Quistgaard EM et al (2009) Ligands bind to sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol 16(1):96\u201398","journal-title":"Nat Struct Mol Biol"},{"issue":"48","key":"806_CR90","doi-asserted-by":"crossref","first-page":"50221","DOI":"10.1074\/jbc.M408873200","volume":"279","author":"UB Westergaard","year":"2004","unstructured":"Westergaard UB et al (2004) Functional organization of the sortilin Vps10p domain. J Biol Chem 279(48):50221\u201350229","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR91","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/mcne.2000.0937","volume":"17","author":"L Vogt","year":"2001","unstructured":"Vogt L et al (2001) Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci 17(1):151\u2013166","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"806_CR92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yexcr.2017.03.001","volume":"358","author":"IS Gul","year":"2017","unstructured":"Gul IS et al (2017) Evolution and diversity of cadherins and catenins. Exp Cell Res 358(1):3\u20139","journal-title":"Exp Cell Res"},{"issue":"3","key":"806_CR93","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/mcne.2002.1181","volume":"21","author":"G Hintsch","year":"2002","unstructured":"Hintsch G et al (2002) The calsyntenins\u2014a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci 21(3):393\u2013409","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"806_CR94","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuron.2013.07.016","volume":"80","author":"KL Pettem","year":"2013","unstructured":"Pettem KL et al (2013) The specific alpha-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development. Neuron 80(1):113\u2013128","journal-title":"Neuron"},{"issue":"6","key":"806_CR95","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/sj.emboj.7601609","volume":"26","author":"Y Araki","year":"2007","unstructured":"Araki Y et al (2007) The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J 26(6):1475\u20131486","journal-title":"EMBO J"},{"issue":"8","key":"806_CR96","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1091\/mbc.e06-02-0112","volume":"17","author":"A Konecna","year":"2006","unstructured":"Konecna A et al (2006) Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell 17(8):3651\u20133663","journal-title":"Mol Biol Cell"},{"issue":"49","key":"806_CR97","doi-asserted-by":"crossref","first-page":"49448","DOI":"10.1074\/jbc.M306024200","volume":"278","author":"Y Araki","year":"2003","unstructured":"Araki Y et al (2003) Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem 278(49):49448\u201349458","journal-title":"J Biol Chem"},{"issue":"13","key":"806_CR98","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1002\/j.1460-2075.1988.tb03306.x","volume":"7","author":"J Herz","year":"1988","unstructured":"Herz J et al (1988) Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 7(13):4119\u20134127","journal-title":"EMBO J"},{"issue":"Pt 1","key":"806_CR99","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/bj3130071","volume":"313","author":"TE Willnow","year":"1996","unstructured":"Willnow TE et al (1996) The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro. Biochem J 313(Pt 1):71\u201376","journal-title":"Biochem J"},{"issue":"2","key":"806_CR100","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.nbd.2008.04.006","volume":"31","author":"E Waldron","year":"2008","unstructured":"Waldron E et al (2008) LRP1 modulates APP trafficking along early compartments of the secretory pathway. Neurobiol Dis 31(2):188\u2013197","journal-title":"Neurobiol Dis"},{"issue":"1","key":"806_CR101","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/156720508783884675","volume":"5","author":"S Jaeger","year":"2008","unstructured":"Jaeger S, Pietrzik CU (2008) Functional role of lipoprotein receptors in Alzheimer\u2019s disease. Curr Alzheimer Res 5(1):15\u201325","journal-title":"Curr Alzheimer Res"},{"issue":"5","key":"806_CR102","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","volume":"10","author":"G Bu","year":"2009","unstructured":"Bu G (2009) Apolipoprotein E and its receptors in Alzheimer\u2019s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10(5):333\u2013344","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"806_CR103","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/1243","volume":"19","author":"D Blacker","year":"1998","unstructured":"Blacker D et al (1998) Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 19(4):357\u2013360","journal-title":"Nat Genet"},{"key":"806_CR104","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.1996.tb32598.x","volume":"802","author":"AD Roses","year":"1996","unstructured":"Roses AD (1996) Apolipoprotein E and Alzheimer\u2019s disease. A rapidly expanding field with medical and epidemiological consequences. Ann N Y Acad Sci 802:50\u201357","journal-title":"Ann N Y Acad Sci"},{"issue":"9","key":"806_CR105","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1172\/JCI11013","volume":"106","author":"DE Kang","year":"2000","unstructured":"Kang DE et al (2000) Modulation of amyloid beta-protein clearance and Alzheimer\u2019s disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest 106(9):1159\u20131166","journal-title":"J Clin Invest"},{"issue":"10","key":"806_CR106","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1074\/jbc.275.10.7410","volume":"275","author":"PG Ulery","year":"2000","unstructured":"Ulery PG et al (2000) Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer\u2019s disease. J Biol Chem 275(10):7410\u20137415","journal-title":"J Biol Chem"},{"issue":"2","key":"806_CR107","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0092-8674(95)90320-8","volume":"82","author":"MZ Kounnas","year":"1995","unstructured":"Kounnas MZ et al (1995) LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82(2):331\u2013340","journal-title":"Cell"},{"issue":"50","key":"806_CR108","doi-asserted-by":"crossref","first-page":"33556","DOI":"10.1074\/jbc.273.50.33556","volume":"273","author":"M Trommsdorff","year":"1998","unstructured":"Trommsdorff M et al (1998) Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem 273(50):33556\u201333560","journal-title":"J Biol Chem"},{"key":"806_CR109","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1749-6632.1996.tb34433.x","volume":"777","author":"R Sandbrink","year":"1996","unstructured":"Sandbrink R, Masters CL, Beyreuther K et al (1996) Ann N Y Acad Sci 777:281\u2013287","journal-title":"Ann N Y Acad Sci"},{"issue":"20","key":"806_CR110","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.febslet.2011.09.028","volume":"585","author":"W Klug","year":"2011","unstructured":"Klug W et al (2011) Phosphorylation of LRP1 regulates the interaction with Fe65. FEBS Lett 585(20):3229\u20133235","journal-title":"FEBS Lett"},{"issue":"17","key":"806_CR111","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1523\/JNEUROSCI.5451-03.2004","volume":"24","author":"CU Pietrzik","year":"2004","unstructured":"Pietrzik CU et al (2004) FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci: Off J Soc Neurosci 24(17):4259\u20134265","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"22","key":"806_CR112","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M000490200","volume":"275","author":"Y Li","year":"2000","unstructured":"Li Y et al (2000) The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. J Biol Chem 275(22):17187\u201317194","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR113","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00018-009-0171-7","volume":"67","author":"SM Reekmans","year":"2010","unstructured":"Reekmans SM et al (2010) Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cell Mol Life Sci 67(1):135\u2013145","journal-title":"Cell Mol Life Sci"},{"issue":"15","key":"806_CR114","doi-asserted-by":"crossref","first-page":"15464","DOI":"10.1074\/jbc.M500613200","volume":"280","author":"JA Cam","year":"2005","unstructured":"Cam JA et al (2005) Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. J Biol Chem 280(15):15464\u201315470","journal-title":"J Biol Chem"},{"issue":"21","key":"806_CR115","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1093\/emboj\/cdf568","volume":"21","author":"CU Pietrzik","year":"2002","unstructured":"Pietrzik CU et al (2002) The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J 21(21):5691\u20135700","journal-title":"EMBO J"},{"issue":"26","key":"806_CR116","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","volume":"269","author":"EH Koo","year":"1994","unstructured":"Koo EH, Squazzo SL (1994) Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 269(26):17386\u201317389","journal-title":"J Biol Chem"},{"key":"806_CR117","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fnmol.2017.00118","volume":"10","author":"UM Herr","year":"2017","unstructured":"Herr UM et al (2017) LRP1 modulates APP intraneuronal transport and processing in its monomeric and dimeric state. Front Mol Neurosci 10:118","journal-title":"Front Mol Neurosci"},{"key":"806_CR118","doi-asserted-by":"publisher","unstructured":"Eggert S et al (2017) Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cell Mol Life Sci. https:\/\/doi.org\/10.1007\/s00018-017-2625-7","DOI":"10.1007\/s00018-017-2625-7"},{"issue":"28","key":"806_CR119","doi-asserted-by":"crossref","first-page":"29639","DOI":"10.1074\/jbc.M313893200","volume":"279","author":"JA Cam","year":"2004","unstructured":"Cam JA et al (2004) The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. J Biol Chem 279(28):29639\u201329646","journal-title":"J Biol Chem"},{"issue":"2","key":"806_CR120","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.atherosclerosis.2011.02.030","volume":"216","author":"J Haas","year":"2011","unstructured":"Haas J et al (2011) LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE-carrying lipoproteins. Atherosclerosis 216(2):342\u2013347","journal-title":"Atherosclerosis"},{"issue":"29","key":"806_CR121","doi-asserted-by":"crossref","first-page":"17401","DOI":"10.1016\/S0021-9258(18)38172-9","volume":"265","author":"DK Strickland","year":"1990","unstructured":"Strickland DK et al (1990) Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem 265(29):17401\u201317404","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"806_CR122","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-5793(90)80530-V","volume":"276","author":"T Kristensen","year":"1990","unstructured":"Kristensen T et al (1990) Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor. FEBS Lett 276(1\u20132):151\u2013155","journal-title":"FEBS Lett"},{"issue":"31","key":"806_CR123","doi-asserted-by":"crossref","first-page":"28889","DOI":"10.1074\/jbc.M102727200","volume":"276","author":"CX Liu","year":"2001","unstructured":"Liu CX et al (2001) The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J Biol Chem 276(31):28889\u201328896","journal-title":"J Biol Chem"},{"issue":"4","key":"806_CR124","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuron.2014.08.005","volume":"83","author":"C Lane-Donovan","year":"2014","unstructured":"Lane-Donovan C, Philips GT, Herz J (2014) More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron 83(4):771\u2013787","journal-title":"Neuron"},{"issue":"18","key":"806_CR125","doi-asserted-by":"crossref","first-page":"17777","DOI":"10.1074\/jbc.M414248200","volume":"280","author":"CA Arnim von","year":"2005","unstructured":"von Arnim CA et al (2005) The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem 280(18):17777\u201317785","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR126","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.expneurol.2010.05.017","volume":"225","author":"B Einem von","year":"2010","unstructured":"von Einem B et al (2010) The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1. Exp Neurol 225(1):85\u201393","journal-title":"Exp Neurol"},{"issue":"21","key":"806_CR127","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.1074\/jbc.M201979200","volume":"277","author":"P May","year":"2002","unstructured":"May P, Reddy YK, Herz J (2002) Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem 277(21):18736\u201318743","journal-title":"J Biol Chem"},{"issue":"29","key":"806_CR128","doi-asserted-by":"crossref","first-page":"27303","DOI":"10.1074\/jbc.M413969200","volume":"280","author":"A Lleo","year":"2005","unstructured":"Lleo A et al (2005) Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem 280(29):27303\u201327309","journal-title":"J Biol Chem"},{"issue":"3","key":"806_CR129","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","volume":"43","author":"R Deane","year":"2004","unstructured":"Deane R et al (2004) LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43(3):333\u2013344","journal-title":"Neuron"},{"issue":"12","key":"806_CR130","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1172\/JCI36663","volume":"118","author":"R Deane","year":"2008","unstructured":"Deane R et al (2008) apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 118(12):4002\u20134013","journal-title":"J Clin Invest"},{"issue":"4","key":"806_CR131","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","volume":"11","author":"GW Rebeck","year":"1993","unstructured":"Rebeck GW et al (1993) Apolipoprotein E in sporadic Alzheimer\u2019s disease: allelic variation and receptor interactions. Neuron 11(4):575\u2013580","journal-title":"Neuron"},{"issue":"12","key":"806_CR132","doi-asserted-by":"crossref","first-page":"2323 e1","DOI":"10.1016\/j.neurobiolaging.2010.05.025","volume":"32","author":"T Pflanzner","year":"2011","unstructured":"Pflanzner T et al (2011) LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier. Neurobiol Aging 32(12):2323 e1\u20132323 11","journal-title":"Neurobiol Aging"},{"issue":"1","key":"806_CR133","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1172\/JCI81108","volume":"126","author":"SE Storck","year":"2016","unstructured":"Storck SE et al (2016) Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier. J Clin Invest 126(1):123\u2013136","journal-title":"J Clin Invest"},{"issue":"12","key":"806_CR134","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","volume":"106","author":"M Shibata","year":"2000","unstructured":"Shibata M et al (2000) Clearance of Alzheimer\u2019s amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106(12):1489\u20131499","journal-title":"J Clin Invest"},{"issue":"9","key":"806_CR135","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nm1635","volume":"13","author":"A Sagare","year":"2007","unstructured":"Sagare A et al (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med 13(9):1029\u20131031","journal-title":"Nat Med"},{"key":"806_CR136","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnagi.2014.00093","volume":"6","author":"T Kanekiyo","year":"2014","unstructured":"Kanekiyo T, Bu G (2014) The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease. Front Aging Neurosci 6:93","journal-title":"Front Aging Neurosci"},{"issue":"9","key":"806_CR137","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/hq0901.094500","volume":"21","author":"K Taira","year":"2001","unstructured":"Taira K et al (2001) LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. Arterioscler Thromb Vasc Biol 21(9):1501\u20131506","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"806_CR138","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1074\/jbc.272.6.3599","volume":"272","author":"CM Petersen","year":"1997","unstructured":"Petersen CM et al (1997) Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 272(6):3599\u20133605","journal-title":"J Biol Chem"},{"issue":"Pt 7","key":"806_CR139","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1242\/jcs.072538","volume":"124","author":"SC Klinger","year":"2011","unstructured":"Klinger SC et al (2011) SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. J Cell Sci 124(Pt 7):1095\u20131105","journal-title":"J Cell Sci"},{"issue":"Pt 1","key":"806_CR140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20040149","volume":"381","author":"J Gliemann","year":"2004","unstructured":"Gliemann J et al (2004) The mosaic receptor sorLA\/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochem J 381(Pt 1):203\u2013212","journal-title":"Biochem J"},{"issue":"25","key":"806_CR141","doi-asserted-by":"crossref","first-page":"22788","DOI":"10.1074\/jbc.M100857200","volume":"276","author":"L Jacobsen","year":"2001","unstructured":"Jacobsen L et al (2001) Activation and functional characterization of the mosaic receptor SorLA\/LR11. J Biol Chem 276(25):22788\u201322796","journal-title":"J Biol Chem"},{"issue":"8","key":"806_CR142","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1128\/MCB.00917-15","volume":"36","author":"JV Larsen","year":"2016","unstructured":"Larsen JV et al (2016) Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover. Mol Cell Biol 36(8):1272\u20131286","journal-title":"Mol Cell Biol"},{"key":"806_CR143","doi-asserted-by":"publisher","unstructured":"Larsen JV, Petersen CM (2017) SorLA and CLC:CLF-1-dependent downregulation of CNTFRalpha as demonstrated by western blotting, inhibition of lysosomal enzymes, and immunocytochemistry. J Vis Exp. https:\/\/doi.org\/10.3791\/55019","DOI":"10.3791\/55019"},{"issue":"8","key":"806_CR144","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/bi052120v","volume":"45","author":"OM Andersen","year":"2006","unstructured":"Andersen OM et al (2006) Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA\/LR11. Biochemistry 45(8):2618\u20132628","journal-title":"Biochemistry"},{"issue":"6","key":"806_CR145","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1074\/jbc.M114.619940","volume":"290","author":"A Mehmedbasic","year":"2015","unstructured":"Mehmedbasic A et al (2015) SorLA complement-type repeat domains protect the amyloid precursor protein against processing. J Biol Chem 290(6):3359\u20133376","journal-title":"J Biol Chem"},{"issue":"2","key":"806_CR146","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1523\/JNEUROSCI.3882-05.2006","volume":"26","author":"R Spoelgen","year":"2006","unstructured":"Spoelgen R et al (2006) Interaction of the cytosolic domains of sorLA\/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci: Off J Soc Neurosci 26(2):418\u2013428","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"223","key":"806_CR147","doi-asserted-by":"crossref","first-page":"223ra20","DOI":"10.1126\/scitranslmed.3007747","volume":"6","author":"S Caglayan","year":"2014","unstructured":"Caglayan S et al (2014) Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer\u2019s disease mutation. Science translational medicine 6(223):223ra20","journal-title":"Science translational medicine"},{"issue":"3","key":"806_CR148","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nsmb.2954","volume":"22","author":"Y Kitago","year":"2015","unstructured":"Kitago Y et al (2015) Structural basis for amyloidogenic peptide recognition by sorLA. Nat Struct Mol Biol 22(3):199\u2013206","journal-title":"Nat Struct Mol Biol"},{"issue":"1\u20132","key":"806_CR149","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0925-4773(97)00177-9","volume":"70","author":"I Hermans-Borgmeyer","year":"1998","unstructured":"Hermans-Borgmeyer I et al (1998) Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. Mech Dev 70(1\u20132):65\u201376","journal-title":"Mech Dev"},{"issue":"5","key":"806_CR150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00401-016-1615-4","volume":"132","author":"OM Andersen","year":"2016","unstructured":"Andersen OM, Rudolph IM, Willnow TE (2016) Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease. Acta Neuropathol 132(5):653\u2013665","journal-title":"Acta Neuropathol"},{"issue":"8","key":"806_CR151","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archneur.61.8.1200","volume":"61","author":"CR Scherzer","year":"2004","unstructured":"Scherzer CR et al (2004) Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 61(8):1200\u20131205","journal-title":"Arch Neurol"},{"issue":"38","key":"806_CR152","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1073\/pnas.0503689102","volume":"102","author":"OM Andersen","year":"2005","unstructured":"Andersen OM et al (2005) Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 102(38):13461\u201313466","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"806_CR153","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1128\/MCB.00628-13","volume":"33","author":"T Burgert","year":"2013","unstructured":"Burgert T et al (2013) SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol 33(21):4308\u20134320","journal-title":"Mol Cell Biol"},{"issue":"1","key":"806_CR154","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1523\/JNEUROSCI.2371-12.2013","volume":"33","author":"C Gustafsen","year":"2013","unstructured":"Gustafsen C et al (2013) Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci: Off J Soc Neurosci 33(1):64\u201371","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"13","key":"806_CR155","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1111\/febs.13758","volume":"283","author":"SC Klinger","year":"2016","unstructured":"Klinger SC et al (2016) Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells. FEBS J 283(13):2476\u20132493","journal-title":"FEBS J"},{"issue":"2","key":"806_CR156","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/BJ20051364","volume":"395","author":"G Hermey","year":"2006","unstructured":"Hermey G et al (2006) Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members. Biochem J 395(2):285\u2013293","journal-title":"Biochem J"},{"issue":"21","key":"806_CR157","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1074\/jbc.M601660200","volume":"281","author":"C Bohm","year":"2006","unstructured":"Bohm C et al (2006) SorLA signaling by regulated intramembrane proteolysis. J Biol Chem 281(21):14547\u201314553","journal-title":"J Biol Chem"},{"issue":"19","key":"806_CR158","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1128\/MCB.00815-07","volume":"27","author":"MS Nielsen","year":"2007","unstructured":"Nielsen MS et al (2007) Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol 27(19):6842\u20136851","journal-title":"Mol Cell Biol"},{"issue":"45","key":"806_CR159","doi-asserted-by":"crossref","first-page":"32956","DOI":"10.1074\/jbc.M705073200","volume":"282","author":"V Schmidt","year":"2007","unstructured":"Schmidt V et al (2007) SorLA\/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem 282(45):32956\u201332964","journal-title":"J Biol Chem"},{"issue":"14","key":"806_CR160","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1091\/mbc.e12-01-0014","volume":"23","author":"JH Herskowitz","year":"2012","unstructured":"Herskowitz JH et al (2012) GGA1-mediated endocytic traffic of LR11\/SorLA alters APP intracellular distribution and amyloid-beta production. Mol Biol Cell 23(14):2645\u20132657","journal-title":"Mol Biol Cell"},{"issue":"1\u20133","key":"806_CR161","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0014-5793(01)03299-9","volume":"511","author":"L Jacobsen","year":"2002","unstructured":"Jacobsen L et al (2002) The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett 511(1\u20133):155\u2013158","journal-title":"FEBS Lett"},{"issue":"37","key":"806_CR162","doi-asserted-by":"crossref","first-page":"12703","DOI":"10.1523\/JNEUROSCI.0427-15.2015","volume":"35","author":"SB Dumanis","year":"2015","unstructured":"Dumanis SB et al (2015) Distinct functions for anterograde and retrograde sorting of SORLA in amyloidogenic processes in the brain. J Neurosci: Off J Soc Neurosci 35(37):12703\u201312713","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"4","key":"806_CR163","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1523\/JNEUROSCI.2272-11.2012","volume":"32","author":"AW Fjorback","year":"2012","unstructured":"Fjorback AW et al (2012) Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci: Off J Soc Neurosci 32(4):1467\u20131480","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"1","key":"806_CR164","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ncb2374","volume":"14","author":"PJ Cullen","year":"2011","unstructured":"Cullen PJ, Korswagen HC (2011) Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol 14(1):29\u201337","journal-title":"Nat Cell Biol"},{"issue":"20","key":"806_CR165","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1073\/pnas.0802545105","volume":"105","author":"A Muhammad","year":"2008","unstructured":"Muhammad A et al (2008) Retromer deficiency observed in Alzheimer\u2019s disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A 105(20):7327\u20137332","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"806_CR166","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.201105109","volume":"195","author":"L Wen","year":"2011","unstructured":"Wen L et al (2011) VPS35 haploinsufficiency increases Alzheimer\u2019s disease neuropathology. J Cell Biol 195(5):765\u2013779","journal-title":"J Cell Biol"},{"issue":"3","key":"806_CR167","doi-asserted-by":"crossref","first-page":"a006312","DOI":"10.1101\/cshperspect.a006312","volume":"2","author":"DM Holtzman","year":"2012","unstructured":"Holtzman DM, Herz J, Bu G (2012) Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med 2(3):a006312","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"1","key":"806_CR168","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/emboj.2011.352","volume":"31","author":"V Schmidt","year":"2012","unstructured":"Schmidt V et al (2012) Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer\u2019s disease. EMBO J 31(1):187\u2013200","journal-title":"EMBO J"},{"issue":"30","key":"806_CR169","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1523\/JNEUROSCI.0206-16.2016","volume":"36","author":"TY Huang","year":"2016","unstructured":"Huang TY et al (2016) SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein. J Neurosci: Off J Soc Neurosci 36(30):7996\u20138011","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"10","key":"806_CR170","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nsmb.3290","volume":"23","author":"T Clairfeuille","year":"2016","unstructured":"Clairfeuille T et al (2016) A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. Nat Struct Mol Biol 23(10):921\u2013932","journal-title":"Nat Struct Mol Biol"},{"issue":"4","key":"806_CR171","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1083\/jcb.201004060","volume":"190","author":"BE Lauffer","year":"2010","unstructured":"Lauffer BE et al (2010) SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J Cell Biol 190(4):565\u2013574","journal-title":"J Cell Biol"},{"issue":"1","key":"806_CR172","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1086\/498851","volume":"78","author":"A Grupe","year":"2006","unstructured":"Grupe A et al (2006) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet 78(1):78\u201388","journal-title":"Am J Hum Genet"},{"issue":"3","key":"806_CR173","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/humu.20953","volume":"30","author":"X Liang","year":"2009","unstructured":"Liang X et al (2009) Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10. Hum Mutat 30(3):463\u2013471","journal-title":"Hum Mutat"},{"issue":"1","key":"806_CR174","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ana.22308","volume":"69","author":"C Reitz","year":"2011","unstructured":"Reitz C et al (2011) SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer\u2019s disease risk. Ann Neurol 69(1):47\u201364","journal-title":"Ann Neurol"},{"key":"806_CR175","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2012.01.067","volume":"1448","author":"HF Wang","year":"2012","unstructured":"Wang HF et al (2012) SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer\u2019s disease in a northern Han Chinese population. Brain Res 1448:111\u2013116","journal-title":"Brain Res"},{"issue":"5","key":"806_CR176","doi-asserted-by":"crossref","first-page":"e63621","DOI":"10.1371\/journal.pone.0063621","volume":"8","author":"W Xu","year":"2013","unstructured":"Xu W et al (2013) The genetic variation of SORCS1 is associated with late-onset Alzheimer\u2019s disease in Chinese Han population. PLoS One 8(5):e63621","journal-title":"PLoS One"},{"issue":"2","key":"806_CR177","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/bbrc.1999.1822","volume":"266","author":"G Hermey","year":"1999","unstructured":"Hermey G et al (1999) Identification and characterization of SorCS, a third member of a novel receptor family. Biochem Biophys Res Commun 266(2):347\u2013351","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"806_CR178","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neuron.2015.08.007","volume":"87","author":"JN Savas","year":"2015","unstructured":"Savas JN et al (2015) The sorting receptor SorCS1 regulates trafficking of neurexin and AMPA receptors. Neuron 87(4):764\u2013780","journal-title":"Neuron"},{"issue":"6288","key":"806_CR179","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1126\/science.aaf2397","volume":"352","author":"L Traunmuller","year":"2016","unstructured":"Traunmuller L et al (2016) Control of neuronal synapse specification by a highly dedicated alternative splicing program. Science 352(6288):982\u2013986","journal-title":"Science"},{"issue":"39","key":"806_CR180","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.3872-10.2010","volume":"30","author":"RF Lane","year":"2010","unstructured":"Lane RF et al (2010) Diabetes-associated SorCS1 regulates Alzheimer\u2019s amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci: Off J Soc Neurosci 30(39):13110\u201313115","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"1","key":"806_CR181","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/jnc.13221","volume":"135","author":"G Hermey","year":"2015","unstructured":"Hermey G et al (2015) SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport. J Neurochem 135(1):60\u201375","journal-title":"J Neurochem"},{"issue":"6","key":"806_CR182","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1046\/j.1471-4159.2004.02286.x","volume":"88","author":"G Hermey","year":"2004","unstructured":"Hermey G et al (2004) The three sorCS genes are differentially expressed and regulated by synaptic activity. J Neurochem 88(6):1470\u20131476","journal-title":"J Neurochem"},{"issue":"1","key":"806_CR183","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00001756-200101220-00014","volume":"12","author":"G Hermey","year":"2001","unstructured":"Hermey G, Schaller HC, Hermans-Borgmeyer I (2001) Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse. Neuroreport 12(1):29\u201332","journal-title":"Neuroreport"},{"issue":"15","key":"806_CR184","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1002\/cne.23606","volume":"522","author":"S Oetjen","year":"2014","unstructured":"Oetjen S et al (2014) Spatiotemporal expression analysis of the growth factor receptor SorCS3. J Comp Neurol 522(15):3386\u20133402","journal-title":"J Comp Neurol"},{"issue":"10","key":"806_CR185","doi-asserted-by":"crossref","first-page":"e24588","DOI":"10.1371\/journal.pone.0024588","volume":"6","author":"C Reitz","year":"2011","unstructured":"Reitz C et al (2011) Impact of genetic variation in SORCS1 on memory retention. PLoS One 6(10):e24588","journal-title":"PLoS One"},{"issue":"9","key":"806_CR186","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1074\/jbc.M210851200","volume":"278","author":"G Hermey","year":"2003","unstructured":"Hermey G et al (2003) Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. J Biol Chem 278(9):7390\u20137396","journal-title":"J Biol Chem"},{"issue":"6","key":"806_CR187","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1600-0854.2008.00731.x","volume":"9","author":"MS Nielsen","year":"2008","unstructured":"Nielsen MS et al (2008) Different motifs regulate trafficking of SorCS1 isoforms. Traffic 9(6):980\u2013994","journal-title":"Traffic"},{"issue":"10","key":"806_CR188","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1600-0854.2012.01396.x","volume":"13","author":"B Doray","year":"2012","unstructured":"Doray B et al (2012) Do GGA adaptors bind internal DXXLL motifs? Traffic 13(10):1315\u20131325","journal-title":"Traffic"},{"issue":"6","key":"806_CR189","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/ng1796","volume":"38","author":"SM Clee","year":"2006","unstructured":"Clee SM et al (2006) Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nat Genet 38(6):688\u2013693","journal-title":"Nat Genet"},{"issue":"7","key":"806_CR190","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.2337\/db06-1677","volume":"56","author":"MO Goodarzi","year":"2007","unstructured":"Goodarzi MO et al (2007) SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes 56(7):1922\u20131929","journal-title":"Diabetes"},{"issue":"3","key":"806_CR191","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1534\/genetics.106.062208","volume":"174","author":"C Granhall","year":"2006","unstructured":"Granhall C et al (2006) High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals <800 kb in the species-conserved Niddm1i of the GK rat. Genetics 174(3):1565\u20131572","journal-title":"Genetics"},{"issue":"2","key":"806_CR192","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/db09-0653","volume":"59","author":"AD Paterson","year":"2010","unstructured":"Paterson AD et al (2010) A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Diabetes 59(2):539\u2013549","journal-title":"Diabetes"},{"issue":"41","key":"806_CR193","doi-asserted-by":"crossref","first-page":"26273","DOI":"10.1074\/jbc.273.41.26273","volume":"273","author":"J Mazella","year":"1998","unstructured":"Mazella J et al (1998) The 100-kDa neurotensin receptor is gp95\/sortilin, a non-G-protein-coupled receptor. J Biol Chem 273(41):26273\u201326276","journal-title":"J Biol Chem"},{"issue":"4","key":"806_CR194","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/cne.10708","volume":"461","author":"P Sarret","year":"2003","unstructured":"Sarret P et al (2003) Distribution of NTS3 receptor\/sortilin mRNA and protein in the rat central nervous system. J Comp Neurol 461(4):483\u2013505","journal-title":"J Comp Neurol"},{"issue":"2","key":"806_CR195","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0169-328X(99)00022-4","volume":"65","author":"I Hermans-Borgmeyer","year":"1999","unstructured":"Hermans-Borgmeyer I et al (1999) Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Brain Res Mol Brain Res 65(2):216\u2013219","journal-title":"Brain Res Mol Brain Res"},{"issue":"3","key":"806_CR196","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/emboj\/18.3.595","volume":"18","author":"C Munck Petersen","year":"1999","unstructured":"Munck Petersen C et al (1999) Propeptide cleavage conditions sortilin\/neurotensin receptor-3 for ligand binding. EMBO J 18(3):595\u2013604","journal-title":"EMBO J"},{"issue":"5","key":"806_CR197","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.febslet.2004.12.088","volume":"579","author":"UB Westergaard","year":"2005","unstructured":"Westergaard UB et al (2005) SorCS3 does not require propeptide cleavage to bind nerve growth factor. FEBS Lett 579(5):1172\u20131176","journal-title":"FEBS Lett"},{"issue":"2","key":"806_CR198","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/BJ20130386","volume":"457","author":"JV Larsen","year":"2014","unstructured":"Larsen JV et al (2014) Human sorCS1 binds sortilin and hampers its cellular functions. Biochem J 457(2):277\u2013288","journal-title":"Biochem J"},{"issue":"6977","key":"806_CR199","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature02319","volume":"427","author":"A Nykjaer","year":"2004","unstructured":"Nykjaer A et al (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427(6977):843\u2013848","journal-title":"Nature"},{"issue":"22","key":"806_CR200","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1523\/JNEUROSCI.5123-04.2005","volume":"25","author":"HK Teng","year":"2005","unstructured":"Teng HK et al (2005) ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci: Off J Soc Neurosci 25(22):5455\u20135463","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"17","key":"806_CR201","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1128\/MCB.00274-10","volume":"30","author":"JV Larsen","year":"2010","unstructured":"Larsen JV et al (2010) Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130\/leukemia inhibitory factor receptor beta heterodimer. Mol Cell Biol 30(17):4175\u20134187","journal-title":"Mol Cell Biol"},{"issue":"13","key":"806_CR202","doi-asserted-by":"crossref","first-page":"8832","DOI":"10.1074\/jbc.274.13.8832","volume":"274","author":"MS Nielsen","year":"1999","unstructured":"Nielsen MS et al (1999) Sortilin\/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem 274(13):8832\u20138836","journal-title":"J Biol Chem"},{"issue":"38","key":"806_CR203","doi-asserted-by":"crossref","first-page":"25920","DOI":"10.1074\/jbc.M802721200","volume":"283","author":"SK Nilsson","year":"2008","unstructured":"Nilsson SK et al (2008) Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem 283(38):25920\u201325927","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR204","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1523\/JNEUROSCI.2425-12.2013","volume":"33","author":"AS Carlo","year":"2013","unstructured":"Carlo AS et al (2013) The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-beta peptide in the brain. J Neurosci: Off J Soc Neurosci 33(1):358\u2013370","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"Pt 14","key":"806_CR205","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1242\/jcs.009654","volume":"120","author":"MN Seaman","year":"2007","unstructured":"Seaman MN (2007) Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval. J Cell Sci 120(Pt 14):2378\u20132389","journal-title":"J Cell Sci"},{"issue":"3","key":"806_CR206","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-0854.2007.00686.x","volume":"9","author":"M Mari","year":"2008","unstructured":"Mari M et al (2008) SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic 9(3):380\u2013393","journal-title":"Traffic"},{"issue":"2","key":"806_CR207","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbrc.2008.06.021","volume":"373","author":"M Canuel","year":"2008","unstructured":"Canuel M et al (2008) Sortilin mediates the lysosomal targeting of cathepsins D and H. Biochem Biophys Res Commun 373(2):292\u2013297","journal-title":"Biochem Biophys Res Commun"},{"issue":"5123","key":"806_CR208","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder EH et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families. Science 261(5123):921\u2013923","journal-title":"Science"},{"issue":"5","key":"806_CR209","doi-asserted-by":"crossref","first-page":"e63049","DOI":"10.1371\/journal.pone.0063049","volume":"8","author":"M Yang","year":"2013","unstructured":"Yang M et al (2013) The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking. PLoS One 8(5):e63049","journal-title":"PLoS One"},{"issue":"20","key":"806_CR210","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1038\/sj.emboj.7600824","volume":"24","author":"P Soba","year":"2005","unstructured":"Soba P et al (2005) Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J 24(20):3624\u20133634","journal-title":"EMBO J"},{"issue":"Pt 5","key":"806_CR211","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jcs.109.5.991","volume":"109","author":"EH Koo","year":"1996","unstructured":"Koo EH et al (1996) Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci 109(Pt 5):991\u2013998","journal-title":"J Cell Sci"},{"issue":"3","key":"806_CR212","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2010.01.015","volume":"18","author":"PV Burgos","year":"2010","unstructured":"Burgos PV et al (2010) Sorting of the Alzheimer\u2019s disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell 18(3):425\u2013436","journal-title":"Dev Cell"},{"key":"806_CR213","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1038\/tp.2013.13","volume":"3","author":"C Reitz","year":"2013","unstructured":"Reitz C et al (2013) Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Transl Psychiatry 3:e256","journal-title":"Transl Psychiatry"},{"issue":"3","key":"806_CR214","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2010.01.023","volume":"471","author":"EJ Mufson","year":"2010","unstructured":"Mufson EJ et al (2010) Preservation of cortical sortilin protein levels in MCI and Alzheimer\u2019s disease. Neurosci Lett 471(3):129\u2013133","journal-title":"Neurosci Lett"},{"key":"806_CR215","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnana.2017.00045","volume":"11","author":"X Hu","year":"2017","unstructured":"Hu X et al (2017) Sortilin fragments deposit at senile plaques in human cerebrum. Front Neuroanat 11:45","journal-title":"Front Neuroanat"},{"issue":"14","key":"806_CR216","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1074\/jbc.M110.170217","volume":"286","author":"GM Finan","year":"2011","unstructured":"Finan GM, Okada H, Kim TW (2011) BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem 286(14):12602\u201312616","journal-title":"J Biol Chem"},{"issue":"2","key":"806_CR217","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jnc.12383","volume":"127","author":"K Saadipour","year":"2013","unstructured":"Saadipour K et al (2013) Amyloid beta(1)(\u2212)(4)(2) (Abeta(4)(2)) up-regulates the expression of sortilin via the p75(NTR)\/RhoA signaling pathway. J Neurochem 127(2):152\u2013162","journal-title":"J Neurochem"},{"issue":"6","key":"806_CR218","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1471-4159.2011.07623.x","volume":"120","author":"J Tan","year":"2012","unstructured":"Tan J, Evin G (2012) Beta-site APP-cleaving enzyme 1 trafficking and Alzheimer\u2019s disease pathogenesis. J Neurochem 120(6):869\u2013880","journal-title":"J Neurochem"},{"key":"806_CR219","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-1-3","volume":"1","author":"AC Nyborg","year":"2006","unstructured":"Nyborg AC et al (2006) Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol Neurodegener 1:3","journal-title":"Mol Neurodegener"},{"issue":"1","key":"806_CR220","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1091\/mbc.e06-01-0014","volume":"18","author":"K Horiuchi","year":"2007","unstructured":"Horiuchi K et al (2007) Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell 18(1):176\u2013188","journal-title":"Mol Biol Cell"},{"issue":"34","key":"806_CR221","doi-asserted-by":"crossref","first-page":"29556","DOI":"10.1074\/jbc.M111.219675","volume":"286","author":"SF Evans","year":"2011","unstructured":"Evans SF et al (2011) Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. J Biol Chem 286(34):29556\u201329567","journal-title":"J Biol Chem"},{"issue":"5","key":"806_CR222","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0006-291X(02)02564-0","volume":"298","author":"V Navarro","year":"2002","unstructured":"Navarro V, Vincent JP, Mazella J (2002) Shedding of the luminal domain of the neurotensin receptor-3\/sortilin in the HT29 cell line. Biochem Biophys Res Commun 298(5):760\u2013764","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"806_CR223","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/CIRCULATIONAHA.110.976613","volume":"123","author":"L Qi","year":"2011","unstructured":"Qi L et al (2011) Genetic risk score and risk of myocardial infarction in Hispanics. Circulation 123(4):374\u2013380","journal-title":"Circulation"},{"issue":"9","key":"806_CR224","doi-asserted-by":"crossref","first-page":"e46385","DOI":"10.1371\/journal.pone.0046385","volume":"7","author":"F Takeuchi","year":"2012","unstructured":"Takeuchi F et al (2012) Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals. PLoS One 7(9):e46385","journal-title":"PLoS One"},{"issue":"5","key":"806_CR225","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jjcc.2014.02.012","volume":"64","author":"P Arvind","year":"2014","unstructured":"Arvind P et al (2014) CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort. J Cardiol 64(5):339\u2013346","journal-title":"J Cardiol"},{"issue":"14","key":"806_CR226","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1093\/hmg\/ddt141","volume":"22","author":"GT Jones","year":"2013","unstructured":"Jones GT et al (2013) A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet 22(14):2941\u20132947","journal-title":"Hum Mol Genet"},{"issue":"3","key":"806_CR227","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/jhg.2012.124","volume":"58","author":"JY Lee","year":"2013","unstructured":"Lee JY et al (2013) A genome-wide association study of a coronary artery disease risk variant. J Hum Genet 58(3):120\u2013126","journal-title":"J Hum Genet"},{"issue":"3","key":"806_CR228","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/eurheartj\/ehr225","volume":"33","author":"A Angelakopoulou","year":"2012","unstructured":"Angelakopoulou A et al (2012) Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: cardiovascular biomarker genetics collaboration. Eur Heart J 33(3):393\u2013407","journal-title":"Eur Heart J"},{"issue":"3","key":"806_CR229","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2796.2006.01687.x","volume":"260","author":"MJ Stampfer","year":"2006","unstructured":"Stampfer MJ (2006) Cardiovascular disease and Alzheimer\u2019s disease: common links. J Intern Med 260(3):211\u2013223","journal-title":"J Intern Med"},{"issue":"4","key":"806_CR230","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3233\/JAD-160319","volume":"53","author":"CH Andersson","year":"2016","unstructured":"Andersson CH et al (2016) A genetic variant of the sortilin 1 gene is associated with reduced risk of Alzheimer\u2019s disease. J Alzheimers Dis: JAD 53(4):1353\u20131363","journal-title":"J Alzheimers Dis: JAD"},{"issue":"9","key":"806_CR231","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/WNR.0b013e3283619f43","volume":"24","author":"F Zeng","year":"2013","unstructured":"Zeng F et al (2013) No association of SORT1 gene polymorphism with sporadic Alzheimer\u2019s disease in the Chinese Han population. Neuroreport 24(9):464\u2013468","journal-title":"Neuroreport"},{"issue":"4","key":"806_CR232","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/mp.2012.14","volume":"18","author":"JC Lambert","year":"2013","unstructured":"Lambert JC et al (2013) Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer\u2019s disease. Mol Psychiatry 18(4):461\u2013470","journal-title":"Mol Psychiatry"},{"issue":"5","key":"806_CR233","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","volume":"43","author":"AC Naj","year":"2011","unstructured":"Naj AC et al (2011) Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease. Nat Genet 43(5):436\u2013441","journal-title":"Nat Genet"},{"issue":"9","key":"806_CR234","doi-asserted-by":"crossref","first-page":"e1004606","DOI":"10.1371\/journal.pgen.1004606","volume":"10","author":"GW Beecham","year":"2014","unstructured":"Beecham GW et al (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer\u2019s disease and related dementias. PLoS Genet 10(9):e1004606","journal-title":"PLoS Genet"},{"issue":"10","key":"806_CR235","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/hmg\/ddq079","volume":"19","author":"CA Reynolds","year":"2010","unstructured":"Reynolds CA et al (2010) Analysis of lipid pathway genes indicates association of sequence variation near SREBF1\/TOM1L2\/ATPAF2 with dementia risk. Hum Mol Genet 19(10):2068\u20132078","journal-title":"Hum Mol Genet"},{"issue":"2","key":"806_CR236","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","volume":"39","author":"E Rogaeva","year":"2007","unstructured":"Rogaeva E et al (2007) The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39(2):168\u2013177","journal-title":"Nat Genet"},{"issue":"3","key":"806_CR237","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s12031-011-9622-3","volume":"45","author":"ME Ward","year":"2011","unstructured":"Ward ME, Miller BL (2011) Potential mechanisms of progranulin-deficient FTLD. J Mol Neurosci: MN 45(3):574\u2013582","journal-title":"J Mol Neurosci: MN"},{"issue":"8","key":"806_CR238","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrneurol.2012.117","volume":"8","author":"R Rademakers","year":"2012","unstructured":"Rademakers R, Neumann M, Mackenzie IR (2012) Advances in understanding the molecular basis of frontotemporal dementia. Nat Rev Neurol 8(8):423\u2013434","journal-title":"Nat Rev Neurol"},{"issue":"Suppl 5","key":"806_CR239","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1002\/ana.10572","volume":"54","author":"T Bird","year":"2003","unstructured":"Bird T et al (2003) Epidemiology and genetics of frontotemporal dementia\/Pick\u2019s disease. Ann Neurol 54(Suppl 5):S29\u2013S31","journal-title":"Ann Neurol"},{"issue":"4","key":"806_CR240","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuron.2010.09.034","volume":"68","author":"F Hu","year":"2010","unstructured":"Hu F et al (2010) Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 68(4):654\u2013667","journal-title":"Neuron"},{"issue":"6","key":"806_CR241","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ajhg.2010.11.002","volume":"87","author":"MM Carrasquillo","year":"2010","unstructured":"Carrasquillo MM et al (2010) Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. Am J Hum Genet 87(6):890\u2013897","journal-title":"Am J Hum Genet"},{"issue":"6","key":"806_CR242","doi-asserted-by":"crossref","first-page":"e21023","DOI":"10.1371\/journal.pone.0021023","volume":"6","author":"Y Zheng","year":"2011","unstructured":"Zheng Y et al (2011) C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking. PLoS One 6(6):e21023","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"806_CR243","first-page":"S35","volume":"33","author":"TF Gendron","year":"2013","unstructured":"Gendron TF, Rademakers R, Petrucelli L (2013) TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43. J Alzheimers Dis 33(Suppl 1):S35\u2013S45","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"806_CR244","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","volume":"14","author":"M Polymenidou","year":"2011","unstructured":"Polymenidou M et al (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci 14(4):459\u2013468","journal-title":"Nat Neurosci"},{"issue":"52","key":"806_CR245","doi-asserted-by":"crossref","first-page":"21510","DOI":"10.1073\/pnas.1211577110","volume":"109","author":"M Prudencio","year":"2012","unstructured":"Prudencio M et al (2012) Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor. Proc Natl Acad Sci U S A 109(52):21510\u201321515","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"806_CR246","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.brainresrev.2006.04.005","volume":"52","author":"B Rogelj","year":"2006","unstructured":"Rogelj B et al (2006) The X11\/mint family of adaptor proteins. Brain Res Rev 52(2):305\u2013315","journal-title":"Brain Res Rev"},{"issue":"6","key":"806_CR247","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.celrep.2014.02.010","volume":"6","author":"JW Um","year":"2014","unstructured":"Um JW et al (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6(6):1096\u20131109","journal-title":"Cell Rep"},{"issue":"23","key":"806_CR248","doi-asserted-by":"crossref","first-page":"24343","DOI":"10.1074\/jbc.M401925200","volume":"279","author":"Y Araki","year":"2004","unstructured":"Araki Y et al (2004) Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem 279(23):24343\u201324354","journal-title":"J Biol Chem"},{"issue":"52","key":"806_CR249","doi-asserted-by":"crossref","first-page":"36024","DOI":"10.1074\/jbc.M109.057497","volume":"284","author":"S Hata","year":"2009","unstructured":"Hata S et al (2009) Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. J Biol Chem 284(52):36024\u201336033","journal-title":"J Biol Chem"},{"issue":"8","key":"806_CR250","doi-asserted-by":"crossref","first-page":"e43058","DOI":"10.1371\/journal.pone.0043058","volume":"7","author":"C Maruta","year":"2012","unstructured":"Maruta C et al (2012) Constitutive cleavage of the single-pass transmembrane protein alcadeinalpha prevents aberrant peripheral retention of Kinesin-1. PLoS One 7(8):e43058","journal-title":"PLoS One"},{"issue":"6","key":"806_CR251","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/ana.22343","volume":"69","author":"S Hata","year":"2011","unstructured":"Hata S et al (2011) Alternative processing of gamma-secretase substrates in common forms of mild cognitive impairment and Alzheimer\u2019s disease: evidence for gamma-secretase dysfunction. Ann Neurol 69(6):1026\u20131031","journal-title":"Ann Neurol"},{"issue":"13","key":"806_CR252","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/hmg\/dds109","volume":"21","author":"A Vagnoni","year":"2012","unstructured":"Vagnoni A et al (2012) Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Abeta production. Hum Mol Genet 21(13):2845\u20132854","journal-title":"Hum Mol Genet"},{"issue":"1","key":"806_CR253","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1001\/archneurol.2011.642","volume":"69","author":"JM Ringman","year":"2012","unstructured":"Ringman JM et al (2012) Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Arch Neurol 69(1):96\u2013104","journal-title":"Arch Neurol"},{"issue":"5","key":"806_CR254","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.ajpath.2013.01.014","volume":"182","author":"Y Uchida","year":"2013","unstructured":"Uchida Y et al (2013) Calsyntenin-3 C-terminal fragment accumulates in dystrophic neurites surrounding abeta plaques in tg2576 mouse and Alzheimer disease brains: Its neurotoxic role in mediating dystrophic neurite formation. Am J Pathol 182(5):1718\u20131726","journal-title":"Am J Pathol"},{"issue":"5","key":"806_CR255","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1600-0854.2009.00886.x","volume":"10","author":"A Ludwig","year":"2009","unstructured":"Ludwig A et al (2009) Calsyntenins mediate TGN exit of APP in a kinesin-1-dependent manner. Traffic 10(5):572\u2013589","journal-title":"Traffic"},{"issue":"Pt 7","key":"806_CR256","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1242\/jcs.075168","volume":"124","author":"A Vagnoni","year":"2011","unstructured":"Vagnoni A et al (2011) Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1. J Cell Sci 124(Pt 7):1032\u20131042","journal-title":"J Cell Sci"},{"issue":"21","key":"806_CR257","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1002\/pmic.201000384","volume":"10","author":"M Steuble","year":"2010","unstructured":"Steuble M et al (2010) Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics 10(21):3775\u20133788","journal-title":"Proteomics"},{"issue":"7","key":"806_CR258","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1600-0854.2006.00434.x","volume":"7","author":"C Goldsbury","year":"2006","unstructured":"Goldsbury C et al (2006) Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic 7(7):873\u2013888","journal-title":"Traffic"},{"issue":"6","key":"806_CR259","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1083\/jcb.200108057","volume":"156","author":"K Stamer","year":"2002","unstructured":"Stamer K et al (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156(6):1051\u20131063","journal-title":"J Cell Biol"},{"issue":"24","key":"806_CR260","doi-asserted-by":"crossref","first-page":"14761","DOI":"10.1074\/jbc.273.24.14761","volume":"273","author":"JP Borg","year":"1998","unstructured":"Borg JP et al (1998) The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J Biol Chem 273(24):14761\u201314766","journal-title":"J Biol Chem"},{"issue":"4","key":"806_CR261","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1074\/jbc.274.4.2243","volume":"274","author":"S Tomita","year":"1999","unstructured":"Tomita S et al (1999) Interaction of a neuron-specific protein containing PDZ domains with Alzheimer\u2019s amyloid precursor protein. J Biol Chem 274(4):2243\u20132254","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR262","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1091\/mbc.e07-05-0465","volume":"19","author":"P Shrivastava-Ranjan","year":"2008","unstructured":"Shrivastava-Ranjan P et al (2008) Mint3\/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer\u2019s precursor protein from the trans-Golgi network. Mol Biol Cell 19(1):51\u201364","journal-title":"Mol Biol Cell"},{"key":"806_CR263","doi-asserted-by":"publisher","unstructured":"Brunholz S et al (2011) Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp Brain Res. 217(3\u20134):353\u2013364. https:\/\/doi.org\/10.1007\/s00221-011-2870-1","DOI":"10.1007\/s00221-011-2870-1"},{"issue":"33","key":"806_CR264","doi-asserted-by":"crossref","first-page":"31261","DOI":"10.1074\/jbc.M304122200","volume":"278","author":"OM Grbovic","year":"2003","unstructured":"Grbovic OM et al (2003) Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem 278(33):31261\u201331268","journal-title":"J Biol Chem"},{"issue":"50","key":"806_CR265","doi-asserted-by":"crossref","first-page":"31783","DOI":"10.1074\/jbc.271.50.31783","volume":"271","author":"AF Ikin","year":"1996","unstructured":"Ikin AF et al (1996) Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J Biol Chem 271(50):31783\u201331786","journal-title":"J Biol Chem"},{"issue":"1","key":"806_CR266","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.conb.2010.08.016","volume":"21","author":"TJ Siddiqui","year":"2011","unstructured":"Siddiqui TJ, Craig AM (2011) Synaptic organizing complexes. Curr Opin Neurobiol 21(1):132\u2013143","journal-title":"Curr Opin Neurobiol"},{"key":"806_CR267","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1523\/JNEUROSCI.1875-16.2017","volume":"37","author":"S Schilling","year":"2017","unstructured":"Schilling S et al (2017) APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission. J Neurosci 37:5345\u20135365","journal-title":"J Neurosci"},{"key":"806_CR268","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3389\/fncel.2014.00410","volume":"8","author":"R Stahl","year":"2014","unstructured":"Stahl R et al (2014) Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci 8:410","journal-title":"Front Cell Neurosci"},{"issue":"33","key":"806_CR269","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1523\/JNEUROSCI.0180-14.2014","volume":"34","author":"F Baumkotter","year":"2014","unstructured":"Baumkotter F et al (2014) Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. J Neurosci: Off J Soc Neurosci 34(33):11159\u201311172","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"35","key":"806_CR270","doi-asserted-by":"crossref","first-page":"10788","DOI":"10.1523\/JNEUROSCI.2132-09.2009","volume":"29","author":"Z Wang","year":"2009","unstructured":"Wang Z et al (2009) Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci: Off J Soc Neurosci 29(35):10788\u201310801","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"1","key":"806_CR271","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tins.2005.11.003","volume":"29","author":"C Dean","year":"2006","unstructured":"Dean C, Dresbach T (2006) Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function. Trends Neurosci 29(1):21\u201329","journal-title":"Trends Neurosci"},{"issue":"3","key":"806_CR272","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrn2075","volume":"8","author":"MB Dalva","year":"2007","unstructured":"Dalva MB, McClelland AC, Kayser MS (2007) Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci 8(3):206\u2013220","journal-title":"Nat Rev Neurosci"},{"issue":"50","key":"806_CR273","doi-asserted-by":"crossref","first-page":"34530","DOI":"10.1074\/jbc.M114.606806","volume":"289","author":"Z Lu","year":"2014","unstructured":"Lu Z et al (2014) Calsyntenin-3 molecular architecture and interaction with neurexin 1alpha. J Biol Chem 289(50):34530\u201334542","journal-title":"J Biol Chem"},{"issue":"3 Suppl","key":"806_CR274","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2006-9S312","volume":"9","author":"SW Scheff","year":"2006","unstructured":"Scheff SW, Price DA (2006) Alzheimer\u2019s disease-related alterations in synaptic density: neocortex and hippocampus. J Alzheimers Dis: JAD 9(3 Suppl):101\u2013115","journal-title":"J Alzheimers Dis: JAD"},{"issue":"10","key":"806_CR275","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tins.2015.08.006","volume":"38","author":"SD Mhatre","year":"2015","unstructured":"Mhatre SD et al (2015) Microglial malfunction: the third rail in the development of Alzheimer\u2019s disease. Trends Neurosci 38(10):621\u2013636","journal-title":"Trends Neurosci"},{"issue":"3","key":"806_CR276","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1096\/fj.05-4873fje","volume":"20","author":"DM Thomas","year":"2006","unstructured":"Thomas DM, Francescutti-Verbeem DM, Kuhn DM (2006) Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage. FASEB J 20(3):515\u2013517","journal-title":"FASEB J"},{"issue":"4","key":"806_CR277","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","volume":"174","author":"AW Jehle","year":"2006","unstructured":"Jehle AW et al (2006) ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol 174(4):547\u2013556","journal-title":"J Cell Biol"},{"key":"806_CR278","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.conb.2015.10.004","volume":"36","author":"C Villegas-Llerena","year":"2016","unstructured":"Villegas-Llerena C et al (2016) Microglial genes regulating neuroinflammation in the progression of Alzheimer\u2019s disease. Curr Opin Neurobiol 36:74\u201381","journal-title":"Curr Opin Neurobiol"},{"issue":"3","key":"806_CR279","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3233\/JAD-151075","volume":"51","author":"KA Southam","year":"2016","unstructured":"Southam KA, Vincent AJ, Small DH (2016) Do microglia default on network maintenance in Alzheimer\u2019s disease? J Alzheimers Dis 51(3):657\u2013669","journal-title":"J Alzheimers Dis"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-017-0806-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0806-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0806-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T22:34:37Z","timestamp":1719527677000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-017-0806-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":279,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["806"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0806-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}