{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:14:12Z","timestamp":1790187252936,"version":"4.1.0"},"reference-count":163,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["Universal 2016"],"award-info":[{"award-number":["Universal 2016"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s12035-017-0842-6","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T07:51:47Z","timestamp":1516002707000},"page":"6687-6699","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Carnosic Acid as a Promising Agent in Protecting Mitochondria of Brain Cells"],"prefix":"10.1007","volume":"55","author":[{"given":"Marcos Roberto","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"842_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.phytochem.2014.12.026","volume":"115","author":"S Birti\u0107","year":"2015","unstructured":"Birti\u0107 S, Dussort P, Pierre FX, Bily AC, Roller M (2015) Carnosic acid. Phytochemistry 115:9\u201319. https:\/\/doi.org\/10.1016\/j.phytochem.2014.12.026","journal-title":"Phytochemistry"},{"key":"842_CR2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2013.07.022","volume":"65","author":"T Satoh","year":"2013","unstructured":"Satoh T, McKercher SR, Lipton SA (2013) Nrf2\/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med 65:645\u2013657. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.07.022","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"842_CR3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.foodchem.2008.01.058","volume":"110","author":"N Erkan","year":"2008","unstructured":"Erkan N, Ayranci G, Ayranci E (2008) Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol. Food Chem 110(1):76\u201382. https:\/\/doi.org\/10.1016\/j.foodchem.2008.01.058","journal-title":"Food Chem"},{"issue":"1","key":"842_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1021\/jf9026487","volume":"58","author":"L P\u00e9rez-Fons","year":"2010","unstructured":"P\u00e9rez-Fons L, Garz\u00f3n MT, Micol V (2010) Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order. J Agric Food Chem 58(1):161\u2013171. https:\/\/doi.org\/10.1021\/jf9026487","journal-title":"J Agric Food Chem"},{"issue":"9","key":"842_CR5","doi-asserted-by":"publisher","first-page":"6155","DOI":"10.1007\/s12035-015-9519-1","volume":"53","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR (2016) The dietary components carnosic acid and carnosol as neuroprotective agents: a mechanistic view. Mol Neurobiol 53(9):6155\u20136168. https:\/\/doi.org\/10.1007\/s12035-015-9519-1","journal-title":"Mol Neurobiol"},{"issue":"2","key":"842_CR6","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s11130-011-0233-5","volume":"66","author":"EH Doolaege","year":"2011","unstructured":"Doolaege EH, Raes K, De Vos F, Verh\u00e9 R, De Smet S (2011) Absorption, distribution and elimination of carnosic acid, a natural antioxidant from Rosmarinus officinalis, in rats. Plant Foods Hum Nutr 66(2):196\u2013202. https:\/\/doi.org\/10.1007\/s11130-011-0233-5","journal-title":"Plant Foods Hum Nutr"},{"key":"842_CR7","doi-asserted-by":"publisher","unstructured":"Romo Vaquero M, Garc\u00eda Villalba R, Larrosa M, Y\u00e1\u00f1ez-Gasc\u00f3n MJ, Fromentin E, Flanagan J, Roller M, Tom\u00e1s-Barber\u00e1n FA et al (2013) Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. Mol Nutr Food Res 57:1834\u20131846. https:\/\/doi.org\/10.1002\/mnfr.201300052","DOI":"10.1002\/mnfr.201300052"},{"issue":"1","key":"842_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/srep22632","volume":"6","author":"K Kang","year":"2016","unstructured":"Kang K, Tarchick MJ, Yu X, Beight C, Bu P, Yu M (2016) Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa. Sci Rep 6(1):22632. https:\/\/doi.org\/10.1038\/srep22632","journal-title":"Sci Rep"},{"key":"842_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.expneurol.2014.11.008","volume":"264","author":"DM Miller","year":"2015","unstructured":"Miller DM, Singh IN, Wang JA, Hall ED (2015) Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice. Exp Neurol 264:103\u2013110. https:\/\/doi.org\/10.1016\/j.expneurol.2014.11.008","journal-title":"Exp Neurol"},{"key":"842_CR10","doi-asserted-by":"publisher","unstructured":"Ozarowski M, Mikolajczak PL, Bogacz A, Gryszczynska A, Kujawska M, Jodynis-Liebert J, Piasecka A, Napieczynska H et al (2013) Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia 91:261\u2013271. https:\/\/doi.org\/10.1016\/j.fitote.2013.09.012","DOI":"10.1016\/j.fitote.2013.09.012"},{"key":"842_CR11","doi-asserted-by":"publisher","unstructured":"Farr SA, Niehoff ML, Ceddia MA, Herrlinger KA, Lewis BJ, Feng S, Welleford A, Butterfield DA et al (2016) Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice. Physiol Behav 165:328\u2013338. https:\/\/doi.org\/10.1016\/j.physbeh.2016.08.013","DOI":"10.1016\/j.physbeh.2016.08.013"},{"key":"842_CR12","doi-asserted-by":"publisher","unstructured":"Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T et al (2015) Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. J Neurochem 133(6):898\u2013908. https:\/\/doi.org\/10.1111\/jnc.13074","DOI":"10.1111\/jnc.13074"},{"issue":"8","key":"842_CR13","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1002\/jps.22528","volume":"100","author":"SR Vaka","year":"2011","unstructured":"Vaka SR, Murthy SN, Repka MA, Nagy T (2011) Upregulation of endogenous neurotrophin levels in the brain by intranasal administration of carnosic acid. J Pharm Sci 100(8):3139\u20133145. https:\/\/doi.org\/10.1002\/jps.22528","journal-title":"J Pharm Sci"},{"issue":"1","key":"842_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3109\/1061186X.2012.725405","volume":"21","author":"SR Vaka","year":"2013","unstructured":"Vaka SR, Shivakumar HN, Repka MA, Murthy SN (2013) Formulation and evaluation of carnosic acid nanoparticulate system for upregulation of neurotrophins in the brain upon intranasal administration. J Drug Target 21(1):44\u201353. https:\/\/doi.org\/10.3109\/1061186X.2012.725405","journal-title":"J Drug Target"},{"issue":"1-4","key":"842_CR15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/biof.5520250103","volume":"25","author":"ML Genova","year":"2005","unstructured":"Genova ML, Bianchi C, Lenaz G (2005) Supercomplex organization of the mitochondrial respiratory chain and the role of the coenzyme Q pool: pathophysiological implications. Biofactors 25(1-4):5\u201320. https:\/\/doi.org\/10.1002\/biof.5520250103","journal-title":"Biofactors"},{"key":"842_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-94-007-2869-1_1","volume":"942","author":"S Papa","year":"2012","unstructured":"Papa S, Martino PL, Capitanio G, Gaballo A, De Rasmo D, Signorile A, Petruzzella V (2012) The oxidative phosphorylation system in mammalian mitochondria. Adv Exp Med Biol 942:3\u201337. https:\/\/doi.org\/10.1007\/978-94-007-2869-1_1","journal-title":"Adv Exp Med Biol"},{"key":"842_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/nrendo.2017.80","volume":"13","author":"MC Petersen","year":"2017","unstructured":"Petersen MC, Vatner DF, Shulman GI (2017) Regulation of hepatic glucose metabolism in health and disease. Nat Rev Endocrinol 13:572\u2013587. https:\/\/doi.org\/10.1038\/nrendo.2017.80","journal-title":"Nat Rev Endocrinol"},{"issue":"6-7","key":"842_CR18","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bbabio.2010.05.005","volume":"1797","author":"L Contreras","year":"2010","unstructured":"Contreras L, Drago I, Zampese E, Pozzan T (2010) Mitochondria: the calcium connection. Biochim Biophys Acta 1797(6-7):607\u2013618. https:\/\/doi.org\/10.1016\/j.bbabio.2010.05.005","journal-title":"Biochim Biophys Acta"},{"key":"842_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1385\/MN:31:1-3:043","volume":"31","author":"GE Gibson","year":"2005","unstructured":"Gibson GE, Blass JP, Beal MF, Bunik V (2005) The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol Neurobiol 31:43\u201363","journal-title":"Mol Neurobiol"},{"key":"842_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/15216540152845911","volume":"52","author":"H Sch\u00e4gger","year":"2001","unstructured":"Sch\u00e4gger H (2001) Respiratory chain supercomplexes. IUBMB Life 52:119\u2013128","journal-title":"IUBMB Life"},{"issue":"8","key":"842_CR21","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.tibs.2015.05.006","volume":"40","author":"SE Babbitt","year":"2015","unstructured":"Babbitt SE, Sutherland MC, San Francisco B, Mendez DL, Kranz RG (2015) Mitochondrial cytochrome c biogenesis: no longer an enigma. Trends Biochem Sci 40(8):446\u2013455. https:\/\/doi.org\/10.1016\/j.tibs.2015.05.006","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"842_CR22","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1042\/BST20160139","volume":"45","author":"PR Rich","year":"2017","unstructured":"Rich PR (2017) Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies. Biochem Soc Trans 45(3):813\u2013829. https:\/\/doi.org\/10.1042\/BST20160139","journal-title":"Biochem Soc Trans"},{"key":"842_CR23","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/biof.168","volume":"37","author":"ML Genova","year":"2011","unstructured":"Genova ML, Lenaz G (2011) New developments on the functions of coenzyme Q in mitochondria. Biofactors 37:330\u2013354","journal-title":"Biofactors"},{"issue":"6","key":"842_CR24","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","volume":"14","author":"M B\u00e9langer","year":"2011","unstructured":"B\u00e9langer M, Allaman I, Magistretti PJ (2011) Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 14(6):724\u2013738. https:\/\/doi.org\/10.1016\/j.cmet.2011.08.016","journal-title":"Cell Metab"},{"key":"842_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mito.2014.03.003","volume":"15","author":"NJ Bergen Van","year":"2014","unstructured":"Van Bergen NJ, Blake RE, Crowston JG, Trounce IA (2014) Oxidative phosphorylation measurement in cell lines and tissues. Mitochondrion 15:24\u201333. https:\/\/doi.org\/10.1016\/j.mito.2014.03.003","journal-title":"Mitochondrion"},{"issue":"4","key":"842_CR26","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","volume":"86","author":"PJ Magistretti","year":"2015","unstructured":"Magistretti PJ, Allaman I (2015) A cellular perspective on brain energy metabolism and functional imaging. Neuron 86(4):883\u2013901. https:\/\/doi.org\/10.1016\/j.neuron.2015.03.035","journal-title":"Neuron"},{"key":"842_CR27","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.bbabio.2006.03.017","volume":"1757","author":"Y Tsujimoto","year":"2006","unstructured":"Tsujimoto Y, Nakagawa T, Shimizu S (2006) Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta 1757:1297\u20131300","journal-title":"Biochim Biophys Acta"},{"issue":"6203","key":"842_CR28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250256","volume":"345","author":"DR Green","year":"2014","unstructured":"Green DR, Galluzzi L, Kroemer G (2014) Metabolic control of cell death. Science 345(6203):1250256. https:\/\/doi.org\/10.1126\/science.1250256","journal-title":"Science"},{"issue":"8","key":"842_CR29","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/ncb3005","volume":"16","author":"L Galluzzi","year":"2014","unstructured":"Galluzzi L, Bravo-San Pedro JM, Kroemer G (2014) Organelle-specific initiation of cell death. Nat Cell Biol 16(8):728\u2013736. https:\/\/doi.org\/10.1038\/ncb3005","journal-title":"Nat Cell Biol"},{"issue":"2-3","key":"842_CR30","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0300-9084(02)01374-3","volume":"84","author":"C Cand\u00e9","year":"2002","unstructured":"Cand\u00e9 C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, Kroemer G (2002) Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie 84(2-3):215\u2013222. https:\/\/doi.org\/10.1016\/S0300-9084(02)01374-3","journal-title":"Biochimie"},{"key":"842_CR31","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1016\/j.febslet.2007.05.038","volume":"581","author":"B Turk","year":"2007","unstructured":"Turk B, Stoka V (2007) Protease signalling in cell death: caspases versus cysteine cathepsins. FEBS Lett 581:2761\u20132767","journal-title":"FEBS Lett"},{"issue":"1-3","key":"842_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1385\/MN:31:1-3:081","volume":"31","author":"M Naoi","year":"2005","unstructured":"Naoi M, Maruyama W, Shamoto-Nagai M, Yi H, Akao Y, Tanaka M (2005) Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders. Mol Neurobiol 31(1-3):81\u201393. https:\/\/doi.org\/10.1385\/MN:31:1-3:081","journal-title":"Mol Neurobiol"},{"key":"842_CR33","doi-asserted-by":"publisher","first-page":"11168","DOI":"10.1073\/pnas.94.21.11168","volume":"94","author":"LJ Yan","year":"1997","unstructured":"Yan LJ, Levine RL, Sohal RS (1997) Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A 94:11168\u201311172","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1464","key":"842_CR34","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1098\/rstb.2005.1764","volume":"360","author":"L Tretter","year":"2005","unstructured":"Tretter L, Adam-Vizi V (2005) Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. Philos Trans R Soc Lond Ser B Biol Sci 360(1464):2335\u20132345. https:\/\/doi.org\/10.1098\/rstb.2005.1764","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"842_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3109\/10715762.2010.534163","volume":"45","author":"AL McLain","year":"2011","unstructured":"McLain AL, Szweda PA, Szweda LI (2011) \u03b1-Ketoglutarate dehydrogenase: a mitochondrial redox sensor. Free Radic Res 45:29\u201336. https:\/\/doi.org\/10.3109\/10715762.2010.534163","journal-title":"Free Radic Res"},{"key":"842_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/273947","volume":"2012","author":"K Smolkov\u00e1","year":"2012","unstructured":"Smolkov\u00e1 K, Je\u017eek P (2012) The role of mitochondrial NADPH-dependent isocitrate dehydrogenase in cancer cells. Int J Cell Biol 2012:273947. https:\/\/doi.org\/10.1155\/2012\/273947","journal-title":"Int J Cell Biol"},{"key":"842_CR37","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/PL00005371","volume":"359","author":"N Pizzinat","year":"1999","unstructured":"Pizzinat N, Copin N, Vindis C, Parini A, Cambon C (1999) Reactive oxygen species production by monoamine oxidases in intact cells. Naunyn Schmiedeberg's Arch Pharmacol 359:428\u2013431","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"842_CR38","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1385\/MN:27:3:325","volume":"27","author":"GC Brown","year":"2003","unstructured":"Brown GC, Bal-Price A (2003) Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 27:325\u2013355","journal-title":"Mol Neurobiol"},{"key":"842_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.mito.2009.12.142","volume":"10","author":"PB Pun","year":"2010","unstructured":"Pun PB, Lu J, Kan EM, Moochhala S (2010) Gases in the mitochondria. Mitochondrion 10:83\u201393. https:\/\/doi.org\/10.1016\/j.mito.2009.12.142","journal-title":"Mitochondrion"},{"key":"842_CR40","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.mito.2013.01.008","volume":"13","author":"P Venditti","year":"2013","unstructured":"Venditti P, Di Stefano L, Di Meo S (2013) Mitochondrial metabolism of reactive oxygen species. Mitochondrion 13:71\u201382. https:\/\/doi.org\/10.1016\/j.mito.2013.01.008","journal-title":"Mitochondrion"},{"issue":"5","key":"842_CR41","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.mito.2010.05.014","volume":"10","author":"ME Witte","year":"2010","unstructured":"Witte ME, Geurts JJ, de Vries HE, van der Valk P, van Horssen J (2010) Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration? Mitochondrion 10(5):411\u2013418. https:\/\/doi.org\/10.1016\/j.mito.2010.05.014","journal-title":"Mitochondrion"},{"issue":"8","key":"842_CR42","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2174\/1568026615666150827095102","volume":"16","author":"HM Wilkins","year":"2016","unstructured":"Wilkins HM, Swerdlow RH (2016) Relationships between mitochondria and neuroinflammation: implications for Alzheimer's disease. Curr Top Med Chem 16(8):849\u2013857","journal-title":"Curr Top Med Chem"},{"key":"842_CR43","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.mito.2015.02.001","volume":"21","author":"NP Mena","year":"2015","unstructured":"Mena NP, Urrutia PJ, Lourido F, Carrasco CM, N\u00fa\u00f1ez MT (2015) Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders. Mitochondrion 21:92\u2013105. https:\/\/doi.org\/10.1016\/j.mito.2015.02.001","journal-title":"Mitochondrion"},{"key":"842_CR44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","volume":"4","author":"H Sies","year":"2015","unstructured":"Sies H (2015) Oxidative stress: a concept in redox biology and medicine. Redox Biol 4:180\u2013183. https:\/\/doi.org\/10.1016\/j.redox.2015.01.002","journal-title":"Redox Biol"},{"key":"842_CR45","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","volume":"86","author":"H Sies","year":"2017","unstructured":"Sies H, Berndt C, Jones DP (2017) Oxidative stress. Annu Rev Biochem 86:715\u2013748. https:\/\/doi.org\/10.1146\/annurev-biochem-061516-045037","journal-title":"Annu Rev Biochem"},{"issue":"1-2","key":"842_CR46","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","volume":"30","author":"SC Lu","year":"2009","unstructured":"Lu SC (2009) Regulation of glutathione synthesis. Mol Asp Med 30(1-2):42\u201359. https:\/\/doi.org\/10.1016\/j.mam.2008.05.005","journal-title":"Mol Asp Med"},{"key":"842_CR47","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1006\/mgme.2000.3063","volume":"71","author":"DJ O'Donovan","year":"2000","unstructured":"O'Donovan DJ, Fernandes CJ (2000) Mitochondrial glutathione and oxidative stress: implications for pulmonary oxygen toxicity in premature infants. Mol Genet Metab 71:352\u2013358","journal-title":"Mol Genet Metab"},{"issue":"5","key":"842_CR48","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","volume":"1830","author":"SC Lu","year":"2013","unstructured":"Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta 1830(5):3143\u20133153. https:\/\/doi.org\/10.1016\/j.bbagen.2012.09.008","journal-title":"Biochim Biophys Acta"},{"key":"842_CR49","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s12035-014-8705-x","volume":"50","author":"G Morris","year":"2014","unstructured":"Morris G, Anderson G, Dean O, Berk M, Galecki P, Martin-Subero M, Maes M (2014) The glutathione system: a new drug target in neuroimmune disorders. Mol Neurobiol 50:1059\u20131084. https:\/\/doi.org\/10.1007\/s12035-014-8705-x","journal-title":"Mol Neurobiol"},{"key":"842_CR50","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","volume":"47","author":"FR Jornayvaz","year":"2010","unstructured":"Jornayvaz FR, Shulman GI (2010) Regulation of mitochondrial biogenesis. Essays Biochem 47:69\u201384. https:\/\/doi.org\/10.1042\/bse0470069","journal-title":"Essays Biochem"},{"issue":"12a","key":"842_CR51","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1101\/gad.7.12a.2431","volume":"7","author":"CA Virbasius","year":"1993","unstructured":"Virbasius CA, Virbasius JV, Scarpulla RC (1993) NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev 7(12a):2431\u20132445. https:\/\/doi.org\/10.1101\/gad.7.12a.2431","journal-title":"Genes Dev"},{"key":"842_CR52","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1101\/gad.7.3.380","volume":"7","author":"JV Virbasius","year":"1993","unstructured":"Virbasius JV, Virbasius CA, Scarpulla RC (1993) Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Genes Dev 7:380\u2013392","journal-title":"Genes Dev"},{"key":"842_CR53","doi-asserted-by":"publisher","first-page":"9013","DOI":"10.1074\/jbc.M212923200","volume":"278","author":"SN Schreiber","year":"2003","unstructured":"Schreiber SN, Knutti D, Brogli K, Uhlmann T, Kralli A (2003) The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J Biol Chem 278:9013\u20139018","journal-title":"J Biol Chem"},{"issue":"8","key":"842_CR54","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1128\/MCB.8.8.3496","volume":"8","author":"RP Fisher","year":"1988","unstructured":"Fisher RP, Clayton DA (1988) Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol 8(8):3496\u20133509. https:\/\/doi.org\/10.1128\/MCB.8.8.3496","journal-title":"Mol Cell Biol"},{"issue":"3","key":"842_CR55","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.tibs.2007.01.003","volume":"32","author":"J Asin-Cayuela","year":"2007","unstructured":"Asin-Cayuela J, Gustafsson CM (2007) Mitochondrial transcription and its regulation in mammalian cells. Trends Biochem Sci 32(3):111\u2013117. https:\/\/doi.org\/10.1016\/j.tibs.2007.01.003","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"842_CR56","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.dnarep.2010.07.009","volume":"9","author":"C Canugovi","year":"2010","unstructured":"Canugovi C, Maynard S, Bayne AC, Sykora P, Tian J, de Souza-Pinto NC, Croteau DL, Bohr VA (2010) The mitochondrial transcription factor A functions in mitochondrial base excision repair. DNA Repair (Amst) 9(10):1080\u20131089. https:\/\/doi.org\/10.1016\/j.dnarep.2010.07.009","journal-title":"DNA Repair (Amst)"},{"key":"842_CR57","doi-asserted-by":"publisher","unstructured":"Cant\u00f3 C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P et al (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458(7241):1056\u20131060. https:\/\/doi.org\/10.1038\/nature07813","DOI":"10.1038\/nature07813"},{"key":"842_CR58","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/cns.12655","volume":"23","author":"M Golpich","year":"2017","unstructured":"Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A (2017) Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment. CNS Neurosci Ther 23:5\u201322. https:\/\/doi.org\/10.1111\/cns.12655","journal-title":"CNS Neurosci Ther"},{"issue":"11","key":"842_CR59","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1161\/01.RES.0000338597.71702.ad","volume":"103","author":"CA Piantadosi","year":"2008","unstructured":"Piantadosi CA, Carraway MS, Babiker A, Suliman HB (2008) Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103(11):1232\u20131240. https:\/\/doi.org\/10.1161\/01.RES.0000338597.71702.ad","journal-title":"Circ Res"},{"issue":"19","key":"842_CR60","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1101\/gad.269894.115","volume":"29","author":"GW Dorn 2nd","year":"2015","unstructured":"Dorn GW 2nd, Vega RB, Kelly DP (2015) Mitochondrial biogenesis and dynamics in the developing and diseased heart. Genes Dev 29(19):1981\u20131991. https:\/\/doi.org\/10.1101\/gad.269894.115","journal-title":"Genes Dev"},{"issue":"4","key":"842_CR61","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.bbamcr.2010.08.007","volume":"1813","author":"E Deas","year":"2011","unstructured":"Deas E, Wood NW, Plun-Favreau H (2011) Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta 1813(4):623\u2013633. https:\/\/doi.org\/10.1016\/j.bbamcr.2010.08.007","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"842_CR62","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrd4023","volume":"12","author":"PA Andreux","year":"2013","unstructured":"Andreux PA, Houtkooper RH, Auwerx J (2013) Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov 12(6):465\u2013483. https:\/\/doi.org\/10.1038\/nrd4023","journal-title":"Nat Rev Drug Discov"},{"key":"842_CR63","doi-asserted-by":"publisher","first-page":"780179","DOI":"10.1155\/2014\/780179","volume":"2014","author":"P Picone","year":"2014","unstructured":"Picone P, Nuzzo D, Caruana L, Scafidi V, Di Carlo M (2014) Mitochondrial dysfunction: different routes to Alzheimer's disease therapy. Oxidative Med Cell Longev 2014:780179\u2013780111. https:\/\/doi.org\/10.1155\/2014\/780179","journal-title":"Oxidative Med Cell Longev"},{"issue":"3","key":"842_CR64","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s12640-017-9766-1","volume":"32","author":"M Jodeiri Farshbaf","year":"2017","unstructured":"Jodeiri Farshbaf M, Ghaedi K (2017) Huntington's disease and mitochondria. Neurotox Res IN PRESS doi 32(3):518\u2013529. https:\/\/doi.org\/10.1007\/s12640-017-9766-1","journal-title":"Neurotox Res IN PRESS doi"},{"key":"842_CR65","doi-asserted-by":"publisher","first-page":"5507","DOI":"10.2174\/138161282035140911142118","volume":"20","author":"T Valero","year":"2014","unstructured":"Valero T (2014) Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des 20:5507\u20135509","journal-title":"Curr Pharm Des"},{"key":"842_CR66","doi-asserted-by":"publisher","unstructured":"Ito YA, Di Polo A (2017) Mitochondrial dynamics, transport, and quality control: a bottleneck for retinal ganglion cell viability in optic neuropathies. Mitochondrion IN PRESS. doi: https:\/\/doi.org\/10.1016\/j.mito.2017.08.014","DOI":"10.1016\/j.mito.2017.08.014"},{"key":"842_CR67","doi-asserted-by":"publisher","unstructured":"Rodolfo C, Campello S, Cecconi F (2017) Mitophagy in neurodegenerative diseases. Neurochem Int IN PRESS. doi: https:\/\/doi.org\/10.1016\/j.neuint.2017.08.004","DOI":"10.1016\/j.neuint.2017.08.004"},{"key":"842_CR68","doi-asserted-by":"publisher","unstructured":"Chiang S, Kalinowski DS, Jansson PJ, Richardson DR, Huang ML (2017) Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia Neurochem Int IN PRESS. doi: https:\/\/doi.org\/10.1016\/j.neuint.2017.08.002","DOI":"10.1016\/j.neuint.2017.08.002"},{"key":"842_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3292087","volume":"2017","author":"BN VanderVeen","year":"2017","unstructured":"VanderVeen BN, Fix DK, Carson JA (2017) Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation. Oxidative Med Cell Longev 2017:3292087. https:\/\/doi.org\/10.1155\/2017\/3292087","journal-title":"Oxidative Med Cell Longev"},{"issue":"10","key":"842_CR70","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1101\/gad.262758.115","volume":"29","author":"TM Durcan","year":"2015","unstructured":"Durcan TM, Fon EA (2015) The three \u2018P\u2019s of mitophagy: PARKIN, PINK1, and post-translational modifications. Genes Dev 29(10):989\u2013999. https:\/\/doi.org\/10.1101\/gad.262758.115","journal-title":"Genes Dev"},{"issue":"2","key":"842_CR71","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cmet.2014.12.011","volume":"21","author":"M Song","year":"2015","unstructured":"Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd (2015) Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab 21(2):273\u2013285. https:\/\/doi.org\/10.1016\/j.cmet.2014.12.011","journal-title":"Cell Metab"},{"issue":"45","key":"842_CR72","doi-asserted-by":"publisher","first-page":"15927","DOI":"10.1073\/pnas.0407043101","volume":"101","author":"S Cipolat","year":"2004","unstructured":"Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A 101(45):15927\u201315932. https:\/\/doi.org\/10.1073\/pnas.0407043101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"28","key":"842_CR73","doi-asserted-by":"publisher","first-page":"26185","DOI":"10.1074\/jbc.M503062200","volume":"280","author":"H Chen","year":"2005","unstructured":"Chen H, Chomyn A, Chan DC (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280(28):26185\u201326192. https:\/\/doi.org\/10.1074\/jbc.M503062200","journal-title":"J Biol Chem"},{"key":"842_CR74","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S1097-2765(00)80391-3","volume":"4","author":"AM Labrousse","year":"1999","unstructured":"Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM (1999) C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 4:815\u2013826","journal-title":"Mol Cell"},{"key":"842_CR75","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1083\/jcb.200209015","volume":"160","author":"ED Wong","year":"2003","unstructured":"Wong ED, Wagner JA, Scott SV, Okreglak V, Holewinske TJ, Cassidy-Stone A, Nunnari J (2003) The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J Cell Biol 160:303\u2013311","journal-title":"J Cell Biol"},{"issue":"7","key":"842_CR76","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrn2417","volume":"9","author":"AB Knott","year":"2008","unstructured":"Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E (2008) Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9(7):505\u2013518. https:\/\/doi.org\/10.1038\/nrn2417","journal-title":"Nat Rev Neurosci"},{"issue":"1-2","key":"842_CR77","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mito.2006.12.002","volume":"7","author":"J Fukae","year":"2007","unstructured":"Fukae J, Mizuno Y, Hattori N (2007) Mitochondrial dysfunction in Parkinson\u2019s disease. Mitochondrion 7(1-2):58\u201362. https:\/\/doi.org\/10.1016\/j.mito.2006.12.002","journal-title":"Mitochondrion"},{"key":"842_CR78","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.tiv.2017.06.008","volume":"43","author":"P Goswami","year":"2017","unstructured":"Goswami P, Joshi N, Singh S (2017) Neurodegenerative signaling factors and mechanisms in Parkinson\u2019s pathology. Toxicol in Vitro 43:104\u2013112. https:\/\/doi.org\/10.1016\/j.tiv.2017.06.008","journal-title":"Toxicol in Vitro"},{"key":"842_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00508","volume":"8","author":"HM Wilkins","year":"2017","unstructured":"Wilkins HM, Weidling IW, Ji Y, Swerdlow RH (2017) Mitochondria-derived damage-associated molecular patterns in neurodegeneration. Front Immunol 8:508. https:\/\/doi.org\/10.3389\/fimmu.2017.00508","journal-title":"Front Immunol"},{"issue":"2","key":"842_CR80","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s12035-010-8150-4","volume":"43","author":"IP Castro de","year":"2011","unstructured":"de Castro IP, Martins LM, Loh SH (2011) Mitochondrial quality control and Parkinson\u2019s disease: a pathway unfolds. Mol Neurobiol 43(2):80\u201386. https:\/\/doi.org\/10.1007\/s12035-010-8150-4","journal-title":"Mol Neurobiol"},{"issue":"2","key":"842_CR81","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1007\/s12035-014-8740-7","volume":"51","author":"AC Fonseca","year":"2015","unstructured":"Fonseca AC, Moreira PI, Oliveira CR, Cardoso SM, Pinton P, Pereira CF (2015) Amyloid-beta disrupts calcium and redox homeostasis in brain endothelial cells. Mol Neurobiol 51(2):610\u2013622. https:\/\/doi.org\/10.1007\/s12035-014-8740-7","journal-title":"Mol Neurobiol"},{"issue":"5","key":"842_CR82","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1007\/s12035-015-9188-0","volume":"53","author":"N Brustovetsky","year":"2016","unstructured":"Brustovetsky N (2016) Mutant huntingtin and elusive defects in oxidative metabolism and mitochondrial calcium handling. Mol Neurobiol 53(5):2944\u20132953. https:\/\/doi.org\/10.1007\/s12035-015-9188-0","journal-title":"Mol Neurobiol"},{"issue":"8","key":"842_CR83","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1007\/s12035-016-0117-7","volume":"54","author":"H Hu","year":"2016","unstructured":"Hu H, Tan CC, Tan L, Yu JT (2016) A Mitocentric view of Alzheimer\u2019s disease. Mol Neurobiol 54(8):6046\u20136060. https:\/\/doi.org\/10.1007\/s12035-016-0117-7","journal-title":"Mol Neurobiol"},{"key":"842_CR84","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2525967","volume":"2017","author":"Z Liu","year":"2017","unstructured":"Liu Z, Zhou T, Ziegler AC, Dimitrion P, Zuo L (2017) Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications. Oxidative Med Cell Longev 2017:2525967. https:\/\/doi.org\/10.1155\/2017\/2525967","journal-title":"Oxidative Med Cell Longev"},{"key":"842_CR85","first-page":"459","volume":"17","author":"AA Saraiva","year":"1985","unstructured":"Saraiva AA, Borges MM, Madeira MD, Tavares MA, Paula-Barbosa MM (1985) Mitochondrial abnormalities in cortical dendrites from patients with Alzheimer\u2019s disease. J Submicrosc Cytol 17:459\u2013464","journal-title":"J Submicrosc Cytol"},{"key":"842_CR86","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1212\/WNL.40.8.1302","volume":"40","author":"WD Parker Jr","year":"1990","unstructured":"Parker WD Jr, Filley CM, Parks JK (1990) Cytochrome oxidase deficiency in Alzheimer\u2019s disease. Neurology 40:1302\u20131303","journal-title":"Neurology"},{"key":"842_CR87","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.redox.2017.04.010","volume":"12","author":"HM Wilkins","year":"2017","unstructured":"Wilkins HM, Koppel SJ, Bothwell R, Mahnken J, Burns JM, Swerdlow RH (2017) Platelet cytochrome oxidase and citrate synthase activities in APOE \u03b54 carrier and non-carrier Alzheimer\u2019s disease patients. Redox Biol 12:828\u2013832. https:\/\/doi.org\/10.1016\/j.redox.2017.04.010","journal-title":"Redox Biol"},{"key":"842_CR88","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7205747","volume":"2016","author":"N Asiimwe","year":"2016","unstructured":"Asiimwe N, Yeo SG, Kim MS, Jung J, Jeong NY (2016) Nitric oxide: exploring the contextual link with Alzheimer\u2019s disease. Oxidative Med Cell Longev 2016:7205747. https:\/\/doi.org\/10.1155\/2016\/7205747","journal-title":"Oxidative Med Cell Longev"},{"issue":"4","key":"842_CR89","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3233\/JAD-160726","volume":"57","author":"Q Cai","year":"2017","unstructured":"Cai Q, Tammineni P (2017) Mitochondrial aspects of synaptic dysfunction in Alzheimer\u2019s disease. J Alzheimers Dis 57(4):1087\u20131103. https:\/\/doi.org\/10.3233\/JAD-160726","journal-title":"J Alzheimers Dis"},{"key":"842_CR90","doi-asserted-by":"publisher","unstructured":"Gibson GE, Thakkar A (2017) Mitochondria\/metabolic reprogramming in the formation of neurons from peripheral cells: cause or consequence and the implications to their utility. Neurochem Int IN PRESS. doi: https:\/\/doi.org\/10.1016\/j.neuint.2017.06.007","DOI":"10.1016\/j.neuint.2017.06.007"},{"key":"842_CR91","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/jnc.13696","volume":"139 Suppl 1","author":"D Toulorge","year":"2016","unstructured":"Toulorge D, Schapira AH, Hajj R (2016) Molecular changes in the postmortem parkinsonian brain. J Neurochem 139 Suppl 1:27\u201358. https:\/\/doi.org\/10.1111\/jnc.13696","journal-title":"J Neurochem"},{"issue":"6","key":"842_CR92","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1111\/j.1471-4159.1985.tb07192.x","volume":"44","author":"WA Brennan Jr","year":"1985","unstructured":"Brennan WA Jr, Bird ED, Aprille JR (1985) Regional mitochondrial respiratory activity in Huntington\u2019s disease brain. J Neurochem 44(6):1948\u20131950. https:\/\/doi.org\/10.1111\/j.1471-4159.1985.tb07192.x","journal-title":"J Neurochem"},{"key":"842_CR93","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/ana.410430321","volume":"43","author":"J Arenas","year":"1998","unstructured":"Arenas J, Campos Y, Ribacoba R, Mart\u00edn MA, Rubio JC, Ablanedo P, Cabello A (1998) Complex I defect in muscle from patients with Huntington\u2019s disease. Ann Neurol 43:397\u2013400","journal-title":"Ann Neurol"},{"issue":"9","key":"842_CR94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160384","volume":"11","author":"NN Naseri","year":"2016","unstructured":"Naseri NN, Bonica J, Xu H, Park LC, Arjomand J, Chen Z, Gibson GE (2016) Novel metabolic abnormalities in the tricarboxylic acid cycle in peripheral cells from Huntington\u2019s disease patients. PLoS One 11(9):e0160384. https:\/\/doi.org\/10.1371\/journal.pone.0160384","journal-title":"PLoS One"},{"key":"842_CR95","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/898393","volume":"2015","author":"M Vav\u00e1kov\u00e1","year":"2015","unstructured":"Vav\u00e1kov\u00e1 M, \u010eura\u010dkov\u00e1 Z, Trebatick\u00e1 J (2015) Markers of oxidative stress and neuroprogression in depression disorder. Oxidative Med Cell Longev 2015:898393. https:\/\/doi.org\/10.1155\/2015\/898393","journal-title":"Oxidative Med Cell Longev"},{"issue":"6","key":"842_CR96","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/1570159X14666160229114755","volume":"14","author":"Y Bansal","year":"2016","unstructured":"Bansal Y, Kuhad A (2016) Mitochondrial dysfunction in depression. Curr Neuropharmacol 14(6):610\u2013618. https:\/\/doi.org\/10.2174\/1570159X14666160229114755","journal-title":"Curr Neuropharmacol"},{"key":"842_CR97","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.neubiorev.2016.06.040","volume":"68","author":"G Scaini","year":"2016","unstructured":"Scaini G, Rezin GT, Carvalho AF, Streck EL, Berk M, Quevedo J (2016) Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications. Neurosci Biobehav Rev 68:694\u2013713. https:\/\/doi.org\/10.1016\/j.neubiorev.2016.06.040","journal-title":"Neurosci Biobehav Rev"},{"key":"842_CR98","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.schres.2017.05.003","volume":"187","author":"KH Flippo","year":"2017","unstructured":"Flippo KH, Strack S (2017) An emerging role for mitochondrial dynamics in schizophrenia. Schizophr Res 187:26\u201332. https:\/\/doi.org\/10.1016\/j.schres.2017.05.003","journal-title":"Schizophr Res"},{"key":"842_CR99","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.mito.2009.08.009","volume":"9","author":"G Cannino","year":"2009","unstructured":"Cannino G, Ferruggia E, Luparello C, Rinaldi AM (2009) Cadmium and mitochondria. Mitochondrion 9:377\u2013384. https:\/\/doi.org\/10.1016\/j.mito.2009.08.009","journal-title":"Mitochondrion"},{"key":"842_CR100","doi-asserted-by":"publisher","first-page":"140267","DOI":"10.1155\/2015\/140267","volume":"2015","author":"MR Oliveira de","year":"2015","unstructured":"de Oliveira MR (2015) Vitamin A and retinoids as mitochondrial toxicants. Oxidative Med Cell Longev 2015:140267\u2013140213. https:\/\/doi.org\/10.1155\/2015\/140267","journal-title":"Oxidative Med Cell Longev"},{"issue":"6","key":"842_CR101","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3109\/10715762.2014.899694","volume":"48","author":"T Blanco-Ayala","year":"2014","unstructured":"Blanco-Ayala T, And\u00e9rica-Romero AC, Pedraza-Chaverri J (2014) New insights into antioxidant strategies against paraquat toxicity. Free Radic Res 48(6):623\u2013640. https:\/\/doi.org\/10.3109\/10715762.2014.899694","journal-title":"Free Radic Res"},{"key":"842_CR102","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neuint.2015.12.006","volume":"92","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Jardim FR (2016) Cocaine and mitochondria-related signaling in the brain: a mechanistic view and future directions. Neurochem Int 92:58\u201366. https:\/\/doi.org\/10.1016\/j.neuint.2015.12.006","journal-title":"Neurochem Int"},{"issue":"3","key":"842_CR103","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s12640-016-9692-7","volume":"31","author":"AK Maiti","year":"2017","unstructured":"Maiti AK, Saha NC, More SS, Panigrahi AK, Paul G (2017) Neuroprotective efficacy of mitochondrial antioxidant MitoQ in suppressing peroxynitrite-mediated mitochondrial dysfunction inflicted by lead toxicity in the rat brain. Neurotox Res 31(3):358\u2013372. https:\/\/doi.org\/10.1007\/s12640-016-9692-7","journal-title":"Neurotox Res"},{"issue":"2","key":"842_CR104","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/biof.197","volume":"38","author":"H Atamna","year":"2012","unstructured":"Atamna H, Mackey J, Dhahbi JM (2012) Mitochondrial pharmacology: electron transport chain bypass as strategies to treat mitochondrial dysfunction. Biofactors 38(2):158\u2013166. https:\/\/doi.org\/10.1002\/biof.197","journal-title":"Biofactors"},{"issue":"5","key":"842_CR105","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.biotechadv.2012.09.005","volume":"31","author":"J Gruber","year":"2013","unstructured":"Gruber J, Fong S, Chen CB, Yoong S, Pastorin G, Schaffer S, Cheah I, Halliwell B (2013) Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnol Adv 31(5):563\u2013592. https:\/\/doi.org\/10.1016\/j.biotechadv.2012.09.005","journal-title":"Biotechnol Adv"},{"issue":"4","key":"842_CR106","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/biof.1093","volume":"39","author":"DM Kasote","year":"2013","unstructured":"Kasote DM, Hegde MV, Katyare SS (2013) Mitochondrial dysfunction in psychiatric and neurological diseases: cause(s), consequence(s), and implications of antioxidant therapy. Biofactors 39(4):392\u2013406. https:\/\/doi.org\/10.1002\/biof.1093","journal-title":"Biofactors"},{"key":"842_CR107","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/14737175.2016.1205488","volume":"17","author":"S Cardoso","year":"2017","unstructured":"Cardoso S, Sei\u00e7a RM, Moreira PI (2017) Mitochondria as a target for neuroprotection: implications for Alzheimer\u2019s disease. Expert Rev Neurother 17:77\u201391","journal-title":"Expert Rev Neurother"},{"key":"842_CR108","doi-asserted-by":"publisher","unstructured":"Tucker D, Lu Y, Zhang Q (2017) From mitochondrial function to neuroprotection-an emerging role for methylene blue. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-017-0712-2","DOI":"10.1007\/s12035-017-0712-2"},{"key":"842_CR109","doi-asserted-by":"publisher","unstructured":"Salvatori I, Valle C, Ferri A, Carr\u00ec MT (2017) SIRT3 and mitochondrial metabolism in neurodegenerative diseases. Neurochem Int IN PRESS. doi: https:\/\/doi.org\/10.1016\/j.neuint.2017.04.012","DOI":"10.1016\/j.neuint.2017.04.012"},{"issue":"19","key":"842_CR110","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.2174\/0929867324666170316114452","volume":"24","author":"EK Fetisova","year":"2017","unstructured":"Fetisova EK, Chernyak BV, Korshunova GA, Muntyan MS, Skulachev VP (2017) Mitochondria-targeted antioxidants as a prospective therapeutic strategy for multiple sclerosis. Curr Med Chem 24(19):2086\u20132114. https:\/\/doi.org\/10.2174\/0929867324666170316114452","journal-title":"Curr Med Chem"},{"key":"842_CR111","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.phrs.2015.08.021","volume":"100","author":"MR Oliveira de","year":"2015","unstructured":"de Oliveira MR, Nabavi SF, Habtemariam S, Erdogan Orhan I, Daglia M, Nabavi SM (2015) The effects of baicalein and baicalin on mitochondrial function and dynamics: a review. Pharmacol Res 100:296\u2013308. https:\/\/doi.org\/10.1016\/j.phrs.2015.08.021","journal-title":"Pharmacol Res"},{"key":"842_CR112","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.phrs.2015.12.027","volume":"104","author":"MR Oliveira","year":"2016","unstructured":"Oliveira MR, Nabavi SF, Daglia M, Rastrelli L, Nabavi SM (2016) Epigallocatechin gallate and mitochondria\u2014a story of life and death. Pharmacol Res 104:70\u201385. https:\/\/doi.org\/10.1016\/j.phrs.2015.12.027","journal-title":"Pharmacol Res"},{"issue":"5","key":"842_CR113","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.biotechadv.2015.12.014","volume":"34","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Nabavi SM, Braidy N, Setzer WN, Ahmed T, Nabavi SF (2016) Quercetin and the mitochondria: a mechanistic view. Biotechnol Adv 34(5):532\u2013549. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.12.014","journal-title":"Biotechnol Adv"},{"key":"842_CR114","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.biotechadv.2016.04.004","volume":"34","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Jardim FR, Setzer WN, Nabavi SM, Nabavi SF (2016) Curcumin, mitochondrial biogenesis, and mitophagy: exploring recent data and indicating future needs. Biotechnol Adv 34:813\u2013826. https:\/\/doi.org\/10.1016\/j.biotechadv.2016.04.004","journal-title":"Biotechnol Adv"},{"issue":"4","key":"842_CR115","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.bbagen.2016.01.017","volume":"1860","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Nabavi SF, Manayi A, Daglia M, Hajheydari Z, Nabavi SM (2016) Resveratrol and the mitochondria: from triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view. Biochim Biophys Acta 1860(4):727\u2013745. https:\/\/doi.org\/10.1016\/j.bbagen.2016.01.017","journal-title":"Biochim Biophys Acta"},{"key":"842_CR116","doi-asserted-by":"publisher","unstructured":"Jardim FR, de Rossi FT, Nascimento MX, da Silva Barros RG, Borges PA, Prescilio IC, de Oliveira MR (2017) Resveratrol and brain mitochondria: a review. Mol Neurobiol IN PRESS. doi: https:\/\/doi.org\/10.1007\/s12035-017-0448-z","DOI":"10.1007\/s12035-017-0448-z"},{"key":"842_CR117","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mito.2016.05.005","volume":"29","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR (2016) Evidence for genistein as a mitochondriotropic molecule. Mitochondrion 29:35\u201344. https:\/\/doi.org\/10.1016\/j.mito.2016.05.005","journal-title":"Mitochondrion"},{"key":"842_CR118","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/biof.1256","volume":"42","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR (2016) Phloretin-induced cytoprotective effects on mammalian cells: a mechanistic view and future directions. Biofactors 42:13\u201340","journal-title":"Biofactors"},{"key":"842_CR119","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tifs.2017.06.019","volume":"67","author":"MR Oliveira de","year":"2017","unstructured":"de Oliveira MR, Nabavi SF, Nabavi SM, Jardim FR (2017) Omega-3 polyunsaturated fatty acids and mitochondria, back to the future. Trends Food Sci Technol 67:76\u201392. https:\/\/doi.org\/10.1016\/j.tifs.2017.06.019","journal-title":"Trends Food Sci Technol"},{"key":"842_CR120","doi-asserted-by":"publisher","unstructured":"Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R, Wang L, Tsuruga K et al (2015) Carnosic acid attenuates apoptosis induced by amyloid-\u03b2 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells. Neurosci Res 94:1\u20139. https:\/\/doi.org\/10.1016\/j.neures.2014.12.003","DOI":"10.1016\/j.neures.2014.12.003"},{"issue":"4","key":"842_CR121","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1007\/s12035-016-9873-7","volume":"54","author":"CY Lin","year":"2017","unstructured":"Lin CY, Tsai CW (2017) Carnosic acid attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells by inducing autophagy through an enhanced interaction of Parkin and Beclin1. Mol Neurobiol 54(4):2813\u20132822. https:\/\/doi.org\/10.1007\/s12035-016-9873-7","journal-title":"Mol Neurobiol"},{"issue":"9","key":"842_CR122","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1021\/tx300171u","volume":"25","author":"JH Chen","year":"2012","unstructured":"Chen JH, Ou HP, Lin CY, Lin FJ, Wu CR, Chang SW, Tsai CW (2012) Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis. Chem Res Toxicol 25(9):1893\u20131901. https:\/\/doi.org\/10.1021\/tx300171u","journal-title":"Chem Res Toxicol"},{"key":"842_CR123","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.cbi.2015.11.003","volume":"242","author":"MR Oliveira de","year":"2015","unstructured":"de Oliveira MR, Ferreira GC, Schuck PF, Dal Bosco SM (2015) Role for the PI3K\/Akt\/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Chem Biol Interact 242:396\u2013406. https:\/\/doi.org\/10.1016\/j.cbi.2015.11.003","journal-title":"Chem Biol Interact"},{"key":"842_CR124","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.tiv.2015.12.005","volume":"32","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Ferreira GC, Schuck PF (2016) Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: role for PI3K\/Akt\/Nrf2 pathway. Toxicol in Vitro 32:41\u201354. https:\/\/doi.org\/10.1016\/j.tiv.2015.12.005","journal-title":"Toxicol in Vitro"},{"key":"842_CR125","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s12640-016-9620-x","volume":"30","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Peres A, Ferreira GC, Schuck PF, Bosco SM (2016) Carnosic acid affords mitochondrial protection in chlorpyrifos-treated Sh-Sy5y cells. Neurotox Res 30:367\u2013379. https:\/\/doi.org\/10.1007\/s12640-016-9620-x","journal-title":"Neurotox Res"},{"key":"842_CR126","doi-asserted-by":"publisher","unstructured":"de Oliveira MR, da Costa Ferreira G, Peres A, Bosco SM (2017) Carnosic acid suppresses the H2O2-induced mitochondria-related bioenergetics disturbances and redox impairment in SH-SY5Y cells: role for Nrf2. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-016-0372-7","DOI":"10.1007\/s12035-016-0372-7"},{"key":"842_CR127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2012.12.011","volume":"57","author":"DM Miller","year":"2013","unstructured":"Miller DM, Singh IN, Wang JA, Hall ED (2013) Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo. Free Radic Biol Med 57:1\u20139. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.12.011","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"842_CR128","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3233\/JAD-121711","volume":"34","author":"M Balietti","year":"2013","unstructured":"Balietti M, Giorgetti B, Casoli T, Solazzi M, Tamagnini F, Burattini C, Aicardi G, Fattoretti P (2013) Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer\u2019s disease. J Alzheimers Dis 34(4):887\u2013896. https:\/\/doi.org\/10.3233\/JAD-121711","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"842_CR129","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1242\/jcs.171017","volume":"130","author":"KH Flippo","year":"2017","unstructured":"Flippo KH, Strack S (2017) Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci 130(4):671\u2013681. https:\/\/doi.org\/10.1242\/jcs.171017","journal-title":"J Cell Sci"},{"issue":"12","key":"842_CR130","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1089\/ars.2010.3445","volume":"14","author":"IF Sevrioukova","year":"2011","unstructured":"Sevrioukova IF (2011) Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal 14(12):2545\u20132579. https:\/\/doi.org\/10.1089\/ars.2010.3445","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"842_CR131","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/physrev.00013.2006","volume":"87","author":"G Kroemer","year":"2007","unstructured":"Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87(1):99\u2013163. https:\/\/doi.org\/10.1152\/physrev.00013.2006","journal-title":"Physiol Rev"},{"issue":"9","key":"842_CR132","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nrm2952","volume":"11","author":"SW Tait","year":"2010","unstructured":"Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11(9):621\u2013632. https:\/\/doi.org\/10.1038\/nrm2952","journal-title":"Nat Rev Mol Cell Biol"},{"key":"842_CR133","doi-asserted-by":"publisher","unstructured":"Covill-Cooke C, Howden JH, Birsa N, Kittler JT (2017) Ubiquitination at the mitochondria in neuronal health and disease. Neurochem Int IN PRESS. doi: https:\/\/doi.org\/10.1016\/j.neuint.2017.07.003","DOI":"10.1016\/j.neuint.2017.07.003"},{"issue":"5","key":"842_CR134","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1074\/jbc.M408244200","volume":"280","author":"JM Lluis","year":"2005","unstructured":"Lluis JM, Morales A, Blasco C, Colell A, Mari M, Garcia-Ruiz C, Fernandez-Checa JC (2005) Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia. J Biol Chem 280(5):3224\u20133232. https:\/\/doi.org\/10.1074\/jbc.M408244200","journal-title":"J Biol Chem"},{"issue":"3","key":"842_CR135","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1111\/j.1471-4159.2008.05460.x","volume":"106","author":"SG Jarrett","year":"2008","unstructured":"Jarrett SG, Milder JB, Liang LP, Patel M (2008) The ketogenic diet increases mitochondrial glutathione levels. J Neurochem 106(3):1044\u20131051. https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05460.x","journal-title":"J Neurochem"},{"issue":"11","key":"842_CR136","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1089\/ARS.2009.2695","volume":"11","author":"M Mar\u00ed","year":"2009","unstructured":"Mar\u00ed M, Morales A, Colell A, Garc\u00eda-Ruiz C, Fern\u00e1ndez-Checa JC (2009) Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal 11(11):2685\u20132700. https:\/\/doi.org\/10.1089\/ARS.2009.2695","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"842_CR137","doi-asserted-by":"publisher","first-page":"5961","DOI":"10.1007\/s12035-016-0100-3","volume":"54","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Peres A, Ferreira GC, Schuck PF, Gama CS, Bosco SM (2016) Carnosic acid protects mitochondria of human neuroblastoma SH-SY5Y cells exposed to Paraquat through activation of the Nrf2\/HO-1 Axis. Mol Neurobiol 54(8):5961\u20135972. https:\/\/doi.org\/10.1007\/s12035-016-0100-3","journal-title":"Mol Neurobiol"},{"key":"842_CR138","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","volume":"50","author":"R Gozzelino","year":"2010","unstructured":"Gozzelino R, Jeney V, Soares MP (2010) Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50:323\u2013354. https:\/\/doi.org\/10.1146\/annurev.pharmtox.010909.105600","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"842_CR139","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1089\/ars.2013.5746","volume":"21","author":"VO Kaminskyy","year":"2014","unstructured":"Kaminskyy VO, Zhivotovsky B (2014) Free radicals in cross talk between autophagy and apoptosis. Antioxid Redox Signal 21(1):86\u2013102. https:\/\/doi.org\/10.1089\/ars.2013.5746","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"842_CR140","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/sj.cdd.4402135","volume":"14","author":"M Ott","year":"2007","unstructured":"Ott M, Zhivotovsky B, Orrenius S (2007) Role of cardiolipin in cytochrome c release from mitochondria. Cell Death Differ 14(7):1243\u20131247. https:\/\/doi.org\/10.1038\/sj.cdd.4402135","journal-title":"Cell Death Differ"},{"issue":"9","key":"842_CR141","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.tcb.2016.04.006","volume":"26","author":"V Izzo","year":"2016","unstructured":"Izzo V, Bravo-San Pedro JM, Sica V, Kroemer G, Galluzzi L (2016) Mitochondrial permeability transition: new findings and persisting uncertainties. Trends Cell Biol 26(9):655\u2013667. https:\/\/doi.org\/10.1016\/j.tcb.2016.04.006","journal-title":"Trends Cell Biol"},{"issue":"5","key":"842_CR142","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1515\/hsz-2015-0295","volume":"397","author":"N Esteras","year":"2016","unstructured":"Esteras N, Dinkova-Kostova AT, Abramov AY (2016) Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function. Biol Chem 397(5):383\u2013400. https:\/\/doi.org\/10.1515\/hsz-2015-0295","journal-title":"Biol Chem"},{"key":"842_CR143","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","volume":"1","author":"KM Holmstr\u00f6m","year":"2016","unstructured":"Holmstr\u00f6m KM, Kostov RV, Dinkova-Kostova AT (2016) The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol 1:80\u201391. https:\/\/doi.org\/10.1016\/j.cotox.2016.10.002","journal-title":"Curr Opin Toxicol"},{"key":"842_CR144","doi-asserted-by":"publisher","unstructured":"Holmstr\u00f6m KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M et al (2013) Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biol Open 2(8):761\u2013770. https:\/\/doi.org\/10.1242\/bio.20134853","DOI":"10.1242\/bio.20134853"},{"issue":"3","key":"842_CR145","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1042\/BJ20130863","volume":"457","author":"MH Ludtmann","year":"2014","unstructured":"Ludtmann MH, Angelova PR, Zhang Y, Abramov AY, Dinkova-Kostova AT (2014) Nrf2 affects the efficiency of mitochondrial fatty acid oxidation. Biochem J 457(3):415\u2013424. https:\/\/doi.org\/10.1042\/BJ20130863","journal-title":"Biochem J"},{"key":"842_CR146","doi-asserted-by":"publisher","unstructured":"East DA, Fagiani F, Crosby J, Georgakopoulos ND, Bertrand H, Schaap M, Fowkes A, Wells G et al (2014) PMI: a \u0394\u03a8m independent pharmacological regulator of mitophagy. Chem Biol 21(11):1585\u20131596. https:\/\/doi.org\/10.1016\/j.chembiol.2014.09.019","DOI":"10.1016\/j.chembiol.2014.09.019"},{"issue":"8","key":"842_CR147","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1096\/fj.05-4204fje","volume":"20","author":"DP Converso","year":"2006","unstructured":"Converso DP, Taill\u00e9 C, Carreras MC, Jaitovich A, Poderoso JJ, Boczkowski J (2006) HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism. FASEB J 20(8):1236\u20131238. https:\/\/doi.org\/10.1096\/fj.05-4204fje","journal-title":"FASEB J"},{"key":"842_CR148","doi-asserted-by":"publisher","unstructured":"Bindu S, Pal C, Dey S, Goyal M, Alam A, Iqbal MS, Dutta S, Sarkar S et al (2011) Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury. J Biol Chem 286(45):39387\u201339402. https:\/\/doi.org\/10.1074\/jbc.M111.279893","DOI":"10.1074\/jbc.M111.279893"},{"key":"842_CR149","doi-asserted-by":"publisher","unstructured":"Bolisetty S, Traylor A, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD et al (2013) Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells. Am J Physiol Renal Physiol 305(3):F255\u2013F264. https:\/\/doi.org\/10.1152\/ajprenal.00160.2013","DOI":"10.1152\/ajprenal.00160.2013"},{"key":"842_CR150","doi-asserted-by":"publisher","unstructured":"Chen D, Jin Z, Zhang J, Jiang L, Chen K, He X, Song Y, Ke J et al (2016) HO-1 protects against hypoxia\/reoxygenation-induced mitochondrial dysfunction in H9c2 cardiomyocytes. PLoS One 11(5):e0153587. https:\/\/doi.org\/10.1371\/journal.pone.0153587","DOI":"10.1371\/journal.pone.0153587"},{"key":"842_CR151","doi-asserted-by":"crossref","unstructured":"Hull TD, Boddu R, Guo L, Tisher CC, Traylor AM, Patel B, Joseph R, Prabhu SD et al (2016) Heme oxygenase-1 regulates mitochondrial quality control in the heart. JCI Insight 1:e85817","DOI":"10.1172\/jci.insight.85817"},{"key":"842_CR152","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.redox.2013.07.004","volume":"2","author":"S Bansal","year":"2013","unstructured":"Bansal S, Biswas G, Avadhani NG (2013) Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity. Redox Biol 2:273\u2013283. https:\/\/doi.org\/10.1016\/j.redox.2013.07.004","journal-title":"Redox Biol"},{"key":"842_CR153","doi-asserted-by":"publisher","unstructured":"Richetin K, Moulis M, Millet A, Arr\u00e0zola MS, Andraini T, Hua J, Davezac N, Roybon L et al (2017) Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer\u2019s disease. Neurobiol Dis 102:113\u2013124. https:\/\/doi.org\/10.1016\/j.nbd.2017.03.002","DOI":"10.1016\/j.nbd.2017.03.002"},{"key":"842_CR154","doi-asserted-by":"publisher","unstructured":"Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, Maruyama A, Yamamoto M et al (2010) Role of Nrf2 and p62\/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. J Biochem 147(1):73\u201381. https:\/\/doi.org\/10.1093\/jb\/mvp149","DOI":"10.1093\/jb\/mvp149"},{"key":"842_CR155","doi-asserted-by":"publisher","unstructured":"de Oliveira MR, de Bittencourt Brasil F, F\u00fcrstenau CR (2017) Sulforaphane promotes mitochondrial protection in SH-SY5Y cells exposed to hydrogen peroxide by an Nrf2-dependent mechanism. Mol Neurobiol IN PRESS doi: https:\/\/doi.org\/10.1007\/s12035-017-0684-2","DOI":"10.1007\/s12035-017-0684-2"},{"key":"842_CR156","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1111\/j.1471-4159.2009.06394.x","volume":"111","author":"A Tarozzi","year":"2009","unstructured":"Tarozzi A, Morroni F, Merlicco A, Hrelia S, Angeloni C, Cantelli-Forti G, Hrelia P (2009) Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. J Neurochem 111:1161\u20131171. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.06394.x","journal-title":"J Neurochem"},{"issue":"6","key":"842_CR157","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1021\/acs.chemrestox.5b00067","volume":"28","author":"C Angeloni","year":"2015","unstructured":"Angeloni C, Malaguti M, Rizzo B, Barbalace MC, Fabbri D, Hrelia S (2015) Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity. Chem Res Toxicol 28(6):1234\u20131245. https:\/\/doi.org\/10.1021\/acs.chemrestox.5b00067","journal-title":"Chem Res Toxicol"},{"issue":"10","key":"842_CR158","doi-asserted-by":"publisher","first-page":"7858","DOI":"10.1007\/s12035-016-0267-7","volume":"54","author":"MR Oliveira de","year":"2017","unstructured":"de Oliveira MR, F\u00fcrstenau CR, de Souza ICC, da Costa Ferreira G (2017) Tanshinone I attenuates the effects of a challenge with H2O2 on the functions of tricarboxylic acid cycle and respiratory chain in SH-SY5Y cells. Mol Neurobiol 54(10):7858\u20137868. https:\/\/doi.org\/10.1007\/s12035-016-0267-7","journal-title":"Mol Neurobiol"},{"key":"842_CR159","doi-asserted-by":"publisher","unstructured":"de Oliveira MR, da Costa Ferreira G, Brasil FB, Peres A (2017) Pinocembrin suppresses H2O2-induced mitochondrial dysfunction by a mechanism dependent on the Nrf2\/HO-1 Axis in SH-SY5Y cells. Mol Neurobiol IN PRESS. doi: https:\/\/doi.org\/10.1007\/s12035-016-0380-7","DOI":"10.1007\/s12035-016-0380-7"},{"issue":"11","key":"842_CR160","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1007\/s11064-017-2376-8","volume":"42","author":"MR Oliveira de","year":"2017","unstructured":"de Oliveira MR, Brasil FB, Andrade CMB (2017) Naringenin attenuates H2O2-induced mitochondrial dysfunction by an Nrf2-dependent mechanism in SH-SY5Y cells. Neurochem Res 42(11):3341\u20133350. https:\/\/doi.org\/10.1007\/s11064-017-2376-8","journal-title":"Neurochem Res"},{"key":"842_CR161","doi-asserted-by":"publisher","unstructured":"Wang Y, Miao Y, Mir AZ, Cheng L, Wang L, Zhao L, Cui Q, Zhao W et al (2016) Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2\/HO-1 pathway in SH-SY5Y cells. J Neurol Sci 368:223\u2013230. https:\/\/doi.org\/10.1016\/j.jns.2016.07.010","DOI":"10.1016\/j.jns.2016.07.010"},{"key":"842_CR162","doi-asserted-by":"publisher","unstructured":"Cortese K, Daga A, Monticone M, Tavella S, Stefanelli A, Aiello C, Bisio A, Bellese G et al (2016) Carnosic acid induces proteasomal degradation of cyclin B1, RB and SOX2 along with cell growth arrest and apoptosis in GBM cells. Phytomedicine 23(7):679\u2013685. https:\/\/doi.org\/10.1016\/j.phymed.2016.03.007","DOI":"10.1016\/j.phymed.2016.03.007"},{"key":"842_CR163","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1007\/s11064-011-0573-4","volume":"36","author":"CW Tsai","year":"2011","unstructured":"Tsai CW, Lin CY, Lin HH, Chen JH (2011) Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells. Neurochem Res 36:2442\u20132451. https:\/\/doi.org\/10.1007\/s11064-011-0573-4","journal-title":"Neurochem Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-017-0842-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0842-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-017-0842-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T13:57:54Z","timestamp":1660312674000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-017-0842-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":163,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["842"],"URL":"https:\/\/doi.org\/10.1007\/s12035-017-0842-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,15]]},"assertion":[{"value":"13 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The author declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}