{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:34:18Z","timestamp":1790836458469,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"MTA-ELTE NAP B","award":["KTIA NAP_13-2-2014-0004"],"award-info":[{"award-number":["KTIA NAP_13-2-2014-0004"]}]},{"name":"MTA-ELTA NAP B","award":["KTIA NAP_13-2-2014-0004"],"award-info":[{"award-number":["KTIA NAP_13-2-2014-0004"]}]},{"name":"MTA-TTK NAP B","award":["KTIA_NAP_13-2-2015-0003"],"award-info":[{"award-number":["KTIA_NAP_13-2-2015-0003"]}]},{"name":"MTA-TTK NAP B","award":["KTIA_NAP_13-2-2015-0003"],"award-info":[{"award-number":["KTIA_NAP_13-2-2015-0003"]}]},{"name":"MTA-TTK NAP B","award":["KTIA_NAP_13-2-2015-0003"],"award-info":[{"award-number":["KTIA_NAP_13-2-2015-0003"]}]},{"name":"FIEK","award":["FIEK_16-1-2016-0005"],"award-info":[{"award-number":["FIEK_16-1-2016-0005"]}]},{"name":"FIEK","award":["FIEK_16-1-2016-0005"],"award-info":[{"award-number":["FIEK_16-1-2016-0005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s12035-018-0955-6","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T18:18:01Z","timestamp":1519409881000},"page":"7839-7857","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP\/PS1 Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-457X","authenticated-orcid":false,"given":"Katalin","family":"V\u00f6lgyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Badics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J.","family":"Sialana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Guly\u00e1ssy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina Brigitta","family":"Udvari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Kis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Drahos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Lubec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin Adrienna","family":"K\u00e9kesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"955_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2174\/1389203716666151102104653","volume":"17","author":"B Penke","year":"2016","unstructured":"Penke B, Bogar F, Fulop L (2016) Protein folding and misfolding, endoplasmic reticulum stress in neurodegenerative diseases: in trace of novel drug targets. Curr Protein Pept Sci 17:169\u2013182","journal-title":"Curr Protein Pept Sci"},{"key":"955_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/alzrt226","volume":"5","author":"EY Hayden","year":"2013","unstructured":"Hayden EY, Teplow DB (2013) Amyloid beta-protein oligomers and Alzheimer\u2019s disease. Alzheimers Res Ther 5:60","journal-title":"Alzheimers Res Ther"},{"key":"955_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrm2101","volume":"8","author":"C Haass","year":"2007","unstructured":"Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer\u2019s amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101\u2013112","journal-title":"Nat Rev Mol Cell Biol"},{"key":"955_CR4","doi-asserted-by":"publisher","first-page":"E2077","DOI":"10.1073\/pnas.1208635109","volume":"109","author":"RW Choy","year":"2012","unstructured":"Choy RW, Cheng Z, Schekman R (2012) Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid beta (Abeta) production in the trans-Golgi network. Proc Natl Acad Sci U S A 109:E2077\u2013E2082","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR5","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/S0021-9258(19)39106-9","volume":"265","author":"JE Vance","year":"1990","unstructured":"Vance JE (1990) Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 265:7248\u20137256","journal-title":"J Biol Chem"},{"key":"955_CR6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrn2168","volume":"8","author":"FM LaFerla","year":"2007","unstructured":"LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer\u2019s disease. Nat Rev Neurosci 8:499\u2013509","journal-title":"Nat Rev Neurosci"},{"key":"955_CR7","first-page":"11","volume":"10","author":"N Soejima","year":"2013","unstructured":"Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T et al (2013) Intracellular accumulation of toxic turn amyloid-beta is associated with endoplasmic reticulum stress in Alzheimer\u2019s disease. Curr Alzheimer Res 10:11\u201320","journal-title":"Curr Alzheimer Res"},{"key":"955_CR8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.gde.2016.04.006","volume":"38","author":"E Area-Gomez","year":"2016","unstructured":"Area-Gomez E, Schon EA (2016) Mitochondria-associated ER membranes and Alzheimer disease. Curr Opin Genet Dev 38:90\u201396","journal-title":"Curr Opin Genet Dev"},{"key":"955_CR9","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1038\/emboj.2012.202","volume":"31","author":"E Area-Gomez","year":"2012","unstructured":"Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M et al (2012) Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J 31:4106\u20134123","journal-title":"EMBO J"},{"key":"955_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mcn.2012.07.011","volume":"55","author":"EA Schon","year":"2013","unstructured":"Schon EA, Area-Gomez E (2013) Mitochondria-associated ER membranes in Alzheimer disease. Mol Cell Neurosci 55:26\u201336","journal-title":"Mol Cell Neurosci"},{"key":"955_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tcb.2008.12.002","volume":"19","author":"T Hayashi","year":"2009","unstructured":"Hayashi T, Rizzuto R, Hajnoczky G, Su TP (2009) MAM: more than just a housekeeper. Trends Cell Biol 19:81\u201388","journal-title":"Trends Cell Biol"},{"key":"955_CR12","doi-asserted-by":"crossref","first-page":"27494","DOI":"10.1016\/S0021-9258(18)47012-3","volume":"269","author":"AE Rusinol","year":"1994","unstructured":"Rusinol AE, Cui Z, Chen MH, Vance JE (1994) A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem 269:27494\u201327502","journal-title":"J Biol Chem"},{"key":"955_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0079-6603(03)75003-X","volume":"75","author":"JE Vance","year":"2003","unstructured":"Vance JE (2003) Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism. Prog Nucleic Acid Res Mol Biol 75:69\u2013111","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"955_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.molcel.2010.06.029","volume":"39","author":"G Csordas","year":"2010","unstructured":"Csordas G, Varnai P, Golenar T, Roy S, Purkins G, Schneider TG, Balla T, Hajnoczky G (2010) Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol Cell 39:121\u2013132","journal-title":"Mol Cell"},{"key":"955_CR15","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/pnas.1300677110","volume":"110","author":"L Hedskog","year":"2013","unstructured":"Hedskog L, Pinho CM, Filadi R, Ronnback A, Hertwig L, Wiehager B, Larssen P, Gellhaar S et al (2013) Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer\u2019s disease and related models. Proc Natl Acad Sci U S A 110:7916\u20137921","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR16","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.2353\/ajpath.2009.090219","volume":"175","author":"E Area-Gomez","year":"2009","unstructured":"Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE et al (2009) Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol 175:1810\u20131816","journal-title":"Am J Pathol"},{"key":"955_CR17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/jnr.10389","volume":"70","author":"R Castellani","year":"2002","unstructured":"Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME et al (2002) Role of mitochondrial dysfunction in Alzheimer\u2019s disease. J Neurosci Res 70:357\u2013360","journal-title":"J Neurosci Res"},{"key":"955_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.18071\/isz.68.0222","volume":"68","author":"A Szarka","year":"2015","unstructured":"Szarka A (2015) The role of beta-amyloid and mitochondrial dysfunction in the pathogenesis of Alzheimer\u2019s disease. Ideggyogy Sz 68:222\u2013228","journal-title":"Ideggyogy Sz"},{"key":"955_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.0009-9163.2004.00280.x","volume":"66","author":"CL Wellington","year":"2004","unstructured":"Wellington CL (2004) Cholesterol at the crossroads: Alzheimer\u2019s disease and lipid metabolism. Clin Genet 66:1\u201316","journal-title":"Clin Genet"},{"key":"955_CR20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1749-6632.1991.tb00190.x","volume":"640","author":"S Hoyer","year":"1991","unstructured":"Hoyer S (1991) Abnormalities of glucose metabolism in Alzheimer\u2019s disease. Ann N Y Acad Sci 640:53\u201358","journal-title":"Ann N Y Acad Sci"},{"issue":"Suppl 1","key":"955_CR21","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1097\/00002093-200000001-00008","volume":"14","author":"H Akiyama","year":"2000","unstructured":"Akiyama H, Arai T, Kondo H, Tanno E, Haga C, Ikeda K (2000) Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis Assoc Disord 14(Suppl 1):S47\u2013S53","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"955_CR22","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1073\/pnas.1100735108","volume":"108","author":"E Zampese","year":"2011","unstructured":"Zampese E, Fasolato C, Kipanyula MJ, Bortolozzi M, Pozzan T, Pizzo P (2011) Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc Natl Acad Sci U S A 108:2777\u20132782","journal-title":"Proc Natl Acad Sci U S A"},{"key":"955_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","volume":"63","author":"J Kim","year":"2009","unstructured":"Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimer\u2019s disease. Neuron 63:287\u2013303","journal-title":"Neuron"},{"key":"955_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.tins.2016.01.008","volume":"39","author":"S Paillusson","year":"2016","unstructured":"Paillusson S, Stoica R, Gomez-Suaga P, Lau DH, Mueller S, Miller T, Miller CC (2016) There\u2019s something wrong with my MAM; the ER-mitochondria axis and neurodegenerative diseases. Trends Neurosci 39:146\u2013157","journal-title":"Trends Neurosci"},{"key":"955_CR25","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.bbrc.2011.12.022","volume":"417","author":"M Fujimoto","year":"2012","unstructured":"Fujimoto M, Hayashi T, Su TP (2012) The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria. Biochem Biophys Res Commun 417:635\u2013639","journal-title":"Biochem Biophys Res Commun"},{"key":"955_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","volume":"17","author":"JL Jankowsky","year":"2001","unstructured":"Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17:157\u2013165","journal-title":"Biomol Eng"},{"key":"955_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/hmg\/ddh019","volume":"13","author":"JL Jankowsky","year":"2004","unstructured":"Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK et al (2004) Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13:159\u2013170","journal-title":"Hum Mol Genet"},{"key":"955_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","volume":"6","author":"RS Reiserer","year":"2007","unstructured":"Reiserer RS, Harrison FE, Syverud DC, McDonald MP (2007) Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer\u2019s disease. Genes Brain Behav 6:54\u201365","journal-title":"Genes Brain Behav"},{"key":"955_CR29","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1007\/s12035-015-9682-4","volume":"54","author":"K Volgyi","year":"2017","unstructured":"Volgyi K, Haden K, Kis V, Gulyassy P, Badics K, Gyorffy BA, Simor A, Szabo Z et al (2017) Mitochondrial proteome changes correlating with beta-amyloid accumulation. Mol Neurobiol 54:2060\u20132078","journal-title":"Mol Neurobiol"},{"key":"955_CR30","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1038\/nprot.2009.151","volume":"4","author":"MR Wieckowski","year":"2009","unstructured":"Wieckowski MR, Giorgi C, Lebiedzinska M, Duszynski J, Pinton P (2009) Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc 4:1582\u20131590","journal-title":"Nat Protoc"},{"key":"955_CR31","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1002\/pmic.201600234","volume":"16","author":"FJ Sialana","year":"2016","unstructured":"Sialana FJ, Gulyassy P, Majek P, Sjostedt E, Kis V, Muller AC, Rudashevskaya EL, Mulder J et al (2016) Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels. Proteomics 16:2911\u20132920","journal-title":"Proteomics"},{"key":"955_CR32","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1002\/pmic.200401063","volume":"5","author":"LL Manza","year":"2005","unstructured":"Manza LL, Stamer SL, Ham AJ, Codreanu SG, Liebler DC (2005) Sample preparation and digestion for proteomic analyses using spin filters. Proteomics 5:1742\u20131745","journal-title":"Proteomics"},{"key":"955_CR33","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth.1322","volume":"6","author":"JR Wisniewski","year":"2009","unstructured":"Wisniewski JR, Zougman A, Nagaraj N, Mann M (2009) Universal sample preparation method for proteome analysis. Nat Methods 6:359\u2013362","journal-title":"Nat Methods"},{"key":"955_CR34","doi-asserted-by":"publisher","first-page":"4110","DOI":"10.1021\/ac504689z","volume":"87","author":"JR Wisniewski","year":"2015","unstructured":"Wisniewski JR, Gaugaz FZ (2015) Fast and sensitive total protein and peptide assays for proteomic analysis. Anal Chem 87:4110\u20134116","journal-title":"Anal Chem"},{"key":"955_CR35","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1074\/mcp.T500030-MCP200","volume":"4","author":"JV Olsen","year":"2005","unstructured":"Olsen JV, de Godoy LM, Li G, Macek B, Mortensen P, Pesch R, Makarov A, Lange O et al (2005) Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics 4:2010\u20132021","journal-title":"Mol Cell Proteomics"},{"key":"955_CR36","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","volume":"20","author":"DN Perkins","year":"1999","unstructured":"Perkins DN, Pappin DJ, Creasy DM, Cottrell JS (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20:3551\u20133567","journal-title":"Electrophoresis"},{"key":"955_CR37","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/nmeth1113","volume":"4","author":"L Kall","year":"2007","unstructured":"Kall L, Canterbury JD, Weston J, Noble WS, MacCoss MJ (2007) Semi-supervised learning for peptide identification from shotgun proteomics datasets. Nat Methods 4:923\u2013925","journal-title":"Nat Methods"},{"key":"955_CR38","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1021\/acs.jproteome.6b00407","volume":"15","author":"J Veit","year":"2016","unstructured":"Veit J, Sachsenberg T, Chernev A, Aicheler F, Urlaub H, Kohlbacher O (2016) LFQProfiler and RNP(xl): open-source tools for label-free quantification and protein-RNA cross-linking integrated into proteome discoverer. J Proteome Res 15:3441\u20133448","journal-title":"J Proteome Res"},{"key":"955_CR39","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1002\/pmic.201400515","volume":"15","author":"M Pathan","year":"2015","unstructured":"Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM et al (2015) FunRich: an open access standalone functional enrichment and interaction network analysis tool. Proteomics 15:2597\u20132601","journal-title":"Proteomics"},{"key":"955_CR40","doi-asserted-by":"publisher","first-page":"5518","DOI":"10.1074\/jbc.M111.312280","volume":"287","author":"DW Reid","year":"2012","unstructured":"Reid DW, Nicchitta CV (2012) Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. J Biol Chem 287:5518\u20135527","journal-title":"J Biol Chem"},{"key":"955_CR41","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.neurobiolaging.2007.12.005","volume":"30","author":"S Hauptmann","year":"2009","unstructured":"Hauptmann S, Scherping I, Drose S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A et al (2009) Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30:1574\u20131586","journal-title":"Neurobiol Aging"},{"key":"955_CR42","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.biocel.2012.04.023","volume":"44","author":"JJ Hoozemans","year":"2012","unstructured":"Hoozemans JJ, Scheper W (2012) Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration. Int J Biochem Cell Biol 44:1295\u20131298","journal-title":"Int J Biochem Cell Biol"},{"key":"955_CR43","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1248\/bpb.35.269","volume":"35","author":"M Kaneko","year":"2012","unstructured":"Kaneko M, Saito R, Okuma Y, Nomura Y (2012) Possible involvement of ubiquitin ligase HRD1 insolubilization in amyloid beta generation. Biol Pharm Bull 35:269\u2013272","journal-title":"Biol Pharm Bull"},{"key":"955_CR44","doi-asserted-by":"publisher","first-page":"32240","DOI":"10.1074\/jbc.M603106200","volume":"281","author":"M Hiltunen","year":"2006","unstructured":"Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ et al (2006) Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem 281:32240\u201332253","journal-title":"J Biol Chem"},{"key":"955_CR45","doi-asserted-by":"publisher","first-page":"35689","DOI":"10.1074\/jbc.M111.243147","volume":"286","author":"ES Stieren","year":"2011","unstructured":"Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, Barral JM, Boehning D (2011) Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. J Biol Chem 286:35689\u201335698","journal-title":"J Biol Chem"},{"key":"955_CR46","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1128\/MCB.17.9.5317","volume":"17","author":"DD Mosser","year":"1997","unstructured":"Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B (1997) Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17:5317\u20135327","journal-title":"Mol Cell Biol"},{"key":"955_CR47","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1600-0854.2010.01149.x","volume":"12","author":"J Viswanathan","year":"2011","unstructured":"Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ et al (2011) Alzheimer\u2019s disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12:330\u2013348","journal-title":"Traffic"},{"key":"955_CR48","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1126\/science.1067389","volume":"295","author":"PK Auluck","year":"2002","unstructured":"Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson\u2019s disease. Science 295:865\u2013868","journal-title":"Science"},{"key":"955_CR49","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nsmb.1591","volume":"16","author":"FU Hartl","year":"2009","unstructured":"Hartl FU, Hayer-Hartl M (2009) Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol 16:574\u2013581","journal-title":"Nat Struct Mol Biol"},{"key":"955_CR50","doi-asserted-by":"crossref","unstructured":"Yoo BC, Seidl R, Cairns N, Lubec G (1999) Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease. J Neural Transm Suppl 57:315\u201322","DOI":"10.1007\/978-3-7091-6380-1_22"},{"key":"955_CR51","doi-asserted-by":"crossref","unstructured":"Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B (1997) Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17(9):5317\u20135327","DOI":"10.1128\/MCB.17.9.5317"},{"key":"955_CR52","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/jcp.22903","volume":"227","author":"G Verma","year":"2012","unstructured":"Verma G, Datta M (2012) The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death. J Cell Physiol 227:1791\u20131795","journal-title":"J Cell Physiol"},{"key":"955_CR53","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","volume":"11","author":"HO Rashid","year":"2015","unstructured":"Rashid HO, Yadav RK, Kim HR, Chae HJ (2015) ER stress: autophagy induction, inhibition and selection. Autophagy 11:1956\u20131977","journal-title":"Autophagy"},{"key":"955_CR54","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/sj.emboj.7600559","volume":"24","author":"T Simmen","year":"2005","unstructured":"Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH et al (2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J 24:717\u2013729","journal-title":"EMBO J"},{"key":"955_CR55","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.bbabio.2006.05.007","volume":"1757","author":"G Lenaz","year":"2006","unstructured":"Lenaz G, Fato R, Genova ML, Bergamini C, Bianchi C, Biondi A (2006) Mitochondrial complex I: structural and functional aspects. Biochim Biophys Acta 1757:1406\u20131420","journal-title":"Biochim Biophys Acta"},{"key":"955_CR56","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ncb2422","volume":"14","author":"L Liu","year":"2012","unstructured":"Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C et al (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 14:177\u2013185","journal-title":"Nat Cell Biol"},{"key":"955_CR57","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1161\/CIRCRESAHA.112.265819","volume":"111","author":"DA Kubli","year":"2012","unstructured":"Kubli DA, Gustafsson AB (2012) Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res 111:1208\u20131221","journal-title":"Circ Res"},{"key":"955_CR58","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","volume":"9","author":"CC Liu","year":"2013","unstructured":"Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9:106\u2013118","journal-title":"Nat Rev Neurol"},{"key":"955_CR59","doi-asserted-by":"publisher","first-page":"30538","DOI":"10.1074\/jbc.M114.600833","volume":"289","author":"LM Tai","year":"2014","unstructured":"Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR et al (2014) Amyloid-beta pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. J Biol Chem 289:30538\u201330555","journal-title":"J Biol Chem"},{"key":"955_CR60","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3233\/JAD-132543","volume":"43","author":"B Schreiner","year":"2015","unstructured":"Schreiner B, Hedskog L, Wiehager B, Ankarcrona M (2015) Amyloid-beta peptides are generated in mitochondria-associated endoplasmic reticulum membranes. J Alzheimers Dis 43:369\u2013374","journal-title":"J Alzheimers Dis"},{"key":"955_CR61","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1074\/jbc.M607831200","volume":"282","author":"WS Kim","year":"2007","unstructured":"Kim WS, Rahmanto AS, Kamili A, Rye KA, Guillemin GJ, Gelissen IC, Jessup W, Hill AF et al (2007) Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation. J Biol Chem 282:2851\u20132861","journal-title":"J Biol Chem"},{"key":"955_CR62","doi-asserted-by":"publisher","first-page":"e0155400","DOI":"10.1371\/journal.pone.0155400","volume":"11","author":"O Sano","year":"2016","unstructured":"Sano O, Tsujita M, Shimizu Y, Kato R, Kobayashi A, Kioka N, Remaley AT, Michikawa M et al (2016) ABCG1 and ABCG4 suppress gamma-secretase activity and amyloid beta production. PLoS One 11:e0155400","journal-title":"PLoS One"},{"key":"955_CR63","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.biochi.2012.09.025","volume":"95","author":"V Leoni","year":"2013","unstructured":"Leoni V, Caccia C (2013) 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases. Biochimie 95:595\u2013612","journal-title":"Biochimie"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-0955-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-0955-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-0955-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T20:46:18Z","timestamp":1660509978000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-0955-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["955"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-0955-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,22]]},"assertion":[{"value":"16 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}