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It was conducted according to the principles set out in the Declaration of Helsinki. All patients and\/or close relatives gave their written informed consent to participation in the study in paper format, and a blood sample for genetic analysis was obtained from all of them. CNS tissue donors gave their informed written consent for the use of CNS tissue for research purposes. The categorization of ALS patients was performed according to their clinical features (familial or sporadic ALS forms, bulbar or spinal or respiratory onset, rate of progression, and survival time). No experiments with animals were performed in this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"MP, NM, and MJR applied for a PCT application \u201cDiazoxide for use in the treatment of amyotrophic lateral sclerosis (ALS)\u201d (Application number PCT\/EP2011\/064061). The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}