{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:46:31Z","timestamp":1793299591575,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26.102.190\/2009"],"award-info":[{"award-number":["E-26.102.190\/2009"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/201.174\/2014"],"award-info":[{"award-number":["E-26\/201.174\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/203.024\/2015"],"award-info":[{"award-number":["E-26\/203.024\/2015"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["470734\/2012-4"],"award-info":[{"award-number":["470734\/2012-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Neurociencia Translacional","award":["465346\/2014-6"],"award-info":[{"award-number":["465346\/2014-6"]}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Excitotoxicidade e Neuroprotecao","award":["573577\/2008-5"],"award-info":[{"award-number":["573577\/2008-5"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s12035-018-1019-7","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T04:08:28Z","timestamp":1522037308000},"page":"8668-8679","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Perinatal Asphyxia and Brain Development: Mitochondrial Damage Without Anatomical or Cellular Losses"],"prefix":"10.1007","volume":"55","author":[{"given":"Jean Pierre Mendes","family":"Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Ray\u00eae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaia","family":"Silva-Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Ribeiro Paes","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Miranda","family":"Mendonca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Rodrigues-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Szczupak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Regina Souza","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Galina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-1952","authenticated-orcid":false,"given":"Daniela","family":"Uziel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"1019_CR1","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1467-7687.2006.00499.x","volume":"9","author":"M Haan de","year":"2006","unstructured":"de Haan M, Wyatt JS, Roth S, Vargha-Khadem F, Gadian D, Mishkin M (2006) Brain and cognitive-behavioural development after asphyxia at term birth. Dev Sci 9:350\u2013358","journal-title":"Dev Sci"},{"key":"1019_CR2","unstructured":"McGuire W (2006) Perinatal asphyxia. Clin Evid 511\u2013519"},{"key":"1019_CR3","first-page":"409","volume":"83","author":"J Lawn","year":"2005","unstructured":"Lawn J, Shibuya K, Stein C (2005) No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ 83:409\u2013417","journal-title":"Bull World Health Organ"},{"key":"1019_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3109\/01050399709074979","volume":"26","author":"E Borg","year":"1997","unstructured":"Borg E (1997) Perinatal asphyxia, hypoxia, ischemia and hearing loss. An overview. Scand Audiol 26:77\u201391","journal-title":"Scand Audiol"},{"key":"1019_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/bjo.82.1.9","volume":"82","author":"BJ Crofts","year":"1998","unstructured":"Crofts BJ, King R, Johnson A (1998) The contribution of low birth weight to severe vision loss in a geographically defined population. Br J Ophthalmol 82:9\u201313","journal-title":"Br J Ophthalmol"},{"key":"1019_CR6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0887-8994(91)90060-X","volume":"7","author":"A Hill","year":"1991","unstructured":"Hill A (1991) Current concepts of hypoxic-ischemic cerebral injury in the term newborn. Pediatr Neurol 7:317\u2013325","journal-title":"Pediatr Neurol"},{"key":"1019_CR7","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1176\/appi.ajp.159.7.1080","volume":"159","author":"M Cannon","year":"2002","unstructured":"Cannon M, Jones PB, Murray RM (2002) Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry 159:1080\u20131092","journal-title":"Am J Psychiatry"},{"key":"1019_CR8","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1053\/j.semperi.2004.08.001","volume":"28","author":"R Weitzdoerfer","year":"2004","unstructured":"Weitzdoerfer R, Pollak A, Lubec B (2004) Perinatal asphyxia in the rat has lifelong effects on morphology, cognitive functions, and behavior. Semin Perinatol 28:249\u2013256","journal-title":"Semin Perinatol"},{"key":"1019_CR9","doi-asserted-by":"publisher","first-page":"S543","DOI":"10.1161\/CIR.0000000000000267","volume":"132","author":"MH Wyckoff","year":"2015","unstructured":"Wyckoff MH, Aziz K, Escobedo MB, Kapadia VS, Kattwinkel J, Perlman JM, Simon WM, Weiner GM et al (2015) Part 13: neonatal resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 132:S543\u2013S560","journal-title":"Circulation"},{"key":"1019_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(91)91041-X","volume":"543","author":"B Bjelke","year":"1991","unstructured":"Bjelke B, Andersson K, Ogren SO, Bolme P (1991) Asphyctic lesion: proliferation of tyrosine hydroxylase-immunoreactive nerve cell bodies in the rat substantia nigra and functional changes in dopamine neurotransmission. Brain Res 543:1\u20139","journal-title":"Brain Res"},{"key":"1019_CR11","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1002\/jnr.21715","volume":"86","author":"P Morales","year":"2008","unstructured":"Morales P, Fiedler JL, Andr\u00e9s S, Berrios C, Huaiqu\u00edn P, Bustamante D, Cardenas S, Parra E et al (2008) Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis. J Neurosci Res 86:2650\u20132662","journal-title":"J Neurosci Res"},{"key":"1019_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrn3174","volume":"13","author":"MA Yenari","year":"2012","unstructured":"Yenari MA, Han HS (2012) Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci 13:267\u2013278. \n                    https:\/\/doi.org\/10.1038\/nrn3174","journal-title":"Nat Rev Neurosci"},{"key":"1019_CR13","doi-asserted-by":"publisher","first-page":"e77377","DOI":"10.1371\/journal.pone.0077377","volume":"8","author":"M Castillo-Melendez","year":"2013","unstructured":"Castillo-Melendez M, Baburamani AA, Cabalag C, Yawno T, Witjaksono A, Miller SL, Walker DW (2013) Experimental modelling of the consequences of brief late gestation asphyxia on newborn lamb behaviour and brain structure. PLoS One 8:e77377","journal-title":"PLoS One"},{"key":"1019_CR14","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/glia.20420","volume":"54","author":"C Kaur","year":"2006","unstructured":"Kaur C, Sivakumar V, Zhang Y, Ling EA (2006) Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum. Glia 54:826\u2013839","journal-title":"Glia"},{"key":"1019_CR15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1006\/exnr.1997.6497","volume":"146","author":"Y Chen","year":"1997","unstructured":"Chen Y, Hillefors-Berglund M, Herrera-Marschitz M, Bjelke B, Gross J, Andersson K, von Euler G (1997) Perinatal asphyxia induces long-term changes in dopamine D1, D2, and D3 receptor binding in the rat brain. Exp Neurol 146:74\u201380","journal-title":"Exp Neurol"},{"key":"1019_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11011-012-9367-x","volume":"28","author":"SK Souza","year":"2013","unstructured":"Souza SK, Martins TL, Ferreira GD, Vinagre AS, da Silva RSM, Frizzo ME (2013) Metabolic effects of perinatal asphyxia in the rat cerebral cortex. Metab Brain Dis 28:25\u201332","journal-title":"Metab Brain Dis"},{"key":"1019_CR17","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.neuint.2011.01.021","volume":"58","author":"NR Reddy","year":"2011","unstructured":"Reddy NR, Krishnamurthy S, Chourasia TK, Kumar A, Joy KP (2011) Glutamate antagonism fails to reverse mitochondrial dysfunction in late phase of experimental neonatal asphyxia in rats. Neurochem Int 58:582\u2013590","journal-title":"Neurochem Int"},{"key":"1019_CR18","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","volume":"148","author":"J Nunnari","year":"2012","unstructured":"Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148:1145\u20131159","journal-title":"Cell"},{"key":"1019_CR19","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/00004647-199803000-00008","volume":"18","author":"E Gilland","year":"1998","unstructured":"Gilland E, Puka-Sundvall M, Hillered L, Hagberg H (1998) Mitochondrial function and energy metabolism after hypoxia-ischemia in the immature rat brain: involvement of NMDA-receptors. J Cereb Blood Flow Metab 18:297\u2013304","journal-title":"J Cereb Blood Flow Metab"},{"key":"1019_CR20","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/01.STR.20.5.674","volume":"20","author":"AA Rosenberg","year":"1989","unstructured":"Rosenberg AA, Parks JK, Murdaugh E, Parker WD Jr (1989) Mitochondrial function after asphyxia in newborn lambs. Stroke 20:674\u2013679","journal-title":"Stroke"},{"key":"1019_CR21","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000046142","volume":"23","author":"M Puka-Sundvall","year":"2001","unstructured":"Puka-Sundvall M, Gilland E, Hagberg H (2001) Cerebral hypoxia-ischemia in immature rats: involvement of mitochondrial permeability transition? Dev Neurosci 23:192\u2013197","journal-title":"Dev Neurosci"},{"key":"1019_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0165-3806(00)00111-5","volume":"125","author":"M Puka-Sundvall","year":"2000","unstructured":"Puka-Sundvall M, Wallin C, Gilland E, Hallin U, Wang X, Sandberg M, Karlsson JO, Blomgren K et al (2000) Impairment of mitochondrial respiration after cerebral hypoxia\u2013ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. Dev Brain Res 125:43\u201350","journal-title":"Dev Brain Res"},{"key":"1019_CR23","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1523\/JNEUROSCI.4526-04.2005","volume":"25","author":"S Herculano-Houzel","year":"2005","unstructured":"Herculano-Houzel S (2005) Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J Neurosci 25:2518\u20132521","journal-title":"J Neurosci"},{"key":"1019_CR24","doi-asserted-by":"publisher","first-page":"R356","DOI":"10.1152\/ajpcell.1983.244.5.C356","volume":"244","author":"CA Hansen","year":"1983","unstructured":"Hansen CA, Sidell BD (1983) Atlantic hagfish cardiac muscle: metabolic basis of tolerance to anoxia. Am J Phys 244:R356\u2013R362","journal-title":"Am J Phys"},{"key":"1019_CR25","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0014-5793(76)80434-6","volume":"68","author":"KEO \u00c5kerman","year":"1976","unstructured":"\u00c5kerman KEO, Wikstr\u00f6m MKF (1976) Safranine as a probe of the mitochondrial membrane potential. FEBS Lett 68:191\u2013197","journal-title":"FEBS Lett"},{"key":"1019_CR26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neuroscience.2011.10.025","volume":"200","author":"ACC Fonseca da","year":"2012","unstructured":"da Fonseca ACC, Rom\u00e3o L, Amaral RF et al (2012) Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells. Neuroscience 200:130\u2013141","journal-title":"Neuroscience"},{"key":"1019_CR27","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1111\/j.1471-4159.2007.04904.x","volume":"103","author":"FRS Lima","year":"2007","unstructured":"Lima FRS, Arantes CP, Muras AG, Nomizo R, Brentani RR, Martins VR (2007) Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation. J Neurochem 103:2164\u20132176","journal-title":"J Neurochem"},{"key":"1019_CR28","doi-asserted-by":"publisher","first-page":"14108","DOI":"10.1073\/pnas.0804650106","volume":"106","author":"F Bandeira","year":"2009","unstructured":"Bandeira F, Lent R, Herculano-Houzel S (2009) Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat. Proc Natl Acad Sci U S A 106:14108\u201314113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1019_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1590\/S1679-45082015AO3056","volume":"13","author":"V Machado","year":"2015","unstructured":"Machado V, Pimentel S, Pinto F, Nona J (2015) Perinatal ischemic stroke: a five-year retrospective study in a level-III maternity. Einstein 13:65\u201371","journal-title":"Einstein"},{"key":"1019_CR30","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10571-009-9492-1","volume":"30","author":"JK Frizzo","year":"2010","unstructured":"Frizzo JK, Cardoso MP, de Assis AM, Perry ML, Volont\u00e9 C, Frizzo ME (2010) Effects of acute perinatal asphyxia in the rat hippocampus. Cell Mol Neurobiol 30:683\u2013692","journal-title":"Cell Mol Neurobiol"},{"key":"1019_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00221-009-2103-z","volume":"202","author":"P Morales","year":"2010","unstructured":"Morales P, Simola N, Bustamante D, Lisboa F, Fiedler J, Gebicke-Haerter PJ, Morelli M, Tasker RA et al (2010) Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats. Exp Brain Res 202:1\u201314","journal-title":"Exp Brain Res"},{"key":"1019_CR32","doi-asserted-by":"publisher","first-page":"H558","DOI":"10.1152\/ajpheart.01275.2004","volume":"289","author":"JM Gidday","year":"2005","unstructured":"Gidday JM, Gasche YG, Copin J-C, Shah AR, Perez RS, Shapiro SD, Chan PH, Park TS (2005) Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol 289:H558\u2013H568","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1019_CR33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nri1664","volume":"5","author":"SM Allan","year":"2005","unstructured":"Allan SM, Tyrrell PJ, Rothwell NJ (2005) Interleukin-1 and neuronal injury. Nat Rev Immunol 5:629\u2013640","journal-title":"Nat Rev Immunol"},{"key":"1019_CR34","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.expneurol.2005.11.020","volume":"198","author":"W Pan","year":"2006","unstructured":"Pan W, Ding Y, Yu Y, Ohtaki H, Nakamachi T, Kastin AJ (2006) Stroke upregulates TNF\u03b1 transport across the blood\u2013brain barrier. Exp Neurol 198:222\u2013233","journal-title":"Exp Neurol"},{"key":"1019_CR35","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00019052-200102000-00014","volume":"14","author":"C Iadecola","year":"2001","unstructured":"Iadecola C, Alexander M (2001) Cerebral ischemia and inflammation. Curr Opin Neurol 14:89\u201394","journal-title":"Curr Opin Neurol"},{"key":"1019_CR36","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1161\/01.STR.0000206281.77178.ac","volume":"37","author":"MA Yenari","year":"2006","unstructured":"Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG (2006) Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke 37:1087\u20131093","journal-title":"Stroke"},{"key":"1019_CR37","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00221-007-1186-7","volume":"185","author":"N Simola","year":"2008","unstructured":"Simola N, Bustamante D, Pinna A, Pontis S, Morales P, Morelli M, Herrera-Marschitz M (2008) Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats. Exp Brain Res 185:595\u2013601","journal-title":"Exp Brain Res"},{"key":"1019_CR38","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0006-8993(00)03271-6","volume":"892","author":"Y Shibazaki","year":"2001","unstructured":"Shibazaki Y, Nakai A, Koshino T, Yokoyama K (2001) Effect of the immunosuppressant drug FK506 on neonatal cerebral mitochondrial function and energy metabolism after transient intrauterine ischemia in rats. Brain Res 892:351\u2013358","journal-title":"Brain Res"},{"key":"1019_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/01616412.1991.11739961","volume":"13","author":"S Nioka","year":"1991","unstructured":"Nioka S, Smith DS, Mayevsky A, Dobson GP, Veech RL, Subramanian H, Chance B (1991) Age dependence of steady state mitochondrial oxidative metabolism in the in vivo hypoxic dog brain. Neurol Res 13:25\u201332","journal-title":"Neurol Res"},{"key":"1019_CR40","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1046\/j.1365-201X.1996.449170000.x","volume":"156","author":"S Kuroda","year":"1996","unstructured":"Kuroda S, Katsura K-I, Tsuchidate R, Siesjo BK (1996) Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury. Acta Physiol Scand 156:149\u2013150","journal-title":"Acta Physiol Scand"},{"key":"1019_CR41","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0165-3806(00)00110-3","volume":"125","author":"M Puka-Sundvall","year":"2000","unstructured":"Puka-Sundvall M, Gajkowska B, Cholewinski M, Blomgren K, Lazarewicz JW, Hagberg H (2000) Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. Dev Brain Res 125:31\u201341","journal-title":"Dev Brain Res"},{"key":"1019_CR42","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E, Aksentijevi\u0107 D, Sundier SY, Robb EL, Logan A, Nadtochiy SM et al (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515:431\u2013435","journal-title":"Nature"},{"key":"1019_CR43","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s002210100710","volume":"138","author":"E Engidawork","year":"2001","unstructured":"Engidawork E, Loidl F, Chen Y, Kohlhauser C, Stoeckler S, Dell'Anna E, Lubec B, Lubec G et al (2001) Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia. Exp Brain Res 138:375\u2013383","journal-title":"Exp Brain Res"},{"key":"1019_CR44","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1096\/fasebj.11.6.9194529","volume":"11","author":"B Lubec","year":"1997","unstructured":"Lubec B, Mark M, Herrera-Marschitz M et al (1997) Decrease of heart protein kinase C and cyclin- dependent kinase precedes death in perinatal asphyxia of the rat. FASEB J 11:482\u2013492","journal-title":"FASEB J"},{"key":"1019_CR45","first-page":"284","volume":"45","author":"B Lubec","year":"1997","unstructured":"Lubec B, Dell\u2019Anna E, Fang-Kirchner S et al (1997) Decrease of brain protein kinase C, protein kinase a, and cyclin-dependent kinase correlating with pH precedes neuronal death in neonatal asphyxia of the rat. J Investig Med 45:284\u2013294","journal-title":"J Investig Med"},{"key":"1019_CR46","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/glia.22618","volume":"62","author":"K Rosafio","year":"2013","unstructured":"Rosafio K, Pellerin L (2013) Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1\u03b1-mediated transcriptional regulation. Glia 62:477\u2013490","journal-title":"Glia"},{"key":"1019_CR47","doi-asserted-by":"publisher","first-page":"e1486","DOI":"10.7717\/peerj.1486","volume":"3","author":"YM Lages","year":"2015","unstructured":"Lages YM, Nascimento JM, Lemos GA, Galina A, Castilho LR, Rehen SK (2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. PeerJ 3:e1486","journal-title":"PeerJ"},{"key":"1019_CR48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10863-016-9652-1","volume":"49","author":"N Mnatsakanyan","year":"2017","unstructured":"Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA (2017) Physiological roles of the mitochondrial permeability transition pore. J Bioenerg Biomembr 49:13\u201325","journal-title":"J Bioenerg Biomembr"},{"key":"1019_CR49","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1126\/science.286.5443.1347","volume":"286","author":"EA Jonas","year":"1999","unstructured":"Jonas EA, Buchanan J, Kaczmarek LK (1999) Prolonged activation of mitochondrial conductances during synaptic transmission. Science 286:1347\u20131350","journal-title":"Science"},{"key":"1019_CR50","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1073\/pnas.1217823110","volume":"110","author":"V Giorgio","year":"2013","unstructured":"Giorgio V, von Stockum S, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V et al (2013) Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A 110:5887\u20135892","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1019_CR51","doi-asserted-by":"publisher","first-page":"33982","DOI":"10.1074\/jbc.M109.020115","volume":"284","author":"V Giorgio","year":"2009","unstructured":"Giorgio V, Bisetto E, Soriano ME, Dabbeni-Sala F, Basso E, Petronilli V, Forte MA, Bernardi P et al (2009) Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex. J Biol Chem 284:33982\u201333988","journal-title":"J Biol Chem"},{"key":"1019_CR52","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.devcel.2011.08.008","volume":"21","author":"JR Hom","year":"2011","unstructured":"Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA Jr (2011) The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell 21:469\u2013478","journal-title":"Dev Cell"},{"key":"1019_CR53","doi-asserted-by":"publisher","first-page":"4901014","DOI":"10.1155\/2016\/4901014","volume":"2016","author":"E Rocha-Ferreira","year":"2016","unstructured":"Rocha-Ferreira E, Hristova M (2016) Plasticity in the neonatal brain following hypoxic-ischaemic injury. Neural Plast 2016:4901014","journal-title":"Neural Plast"},{"key":"1019_CR54","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00234-010-0674-9","volume":"52","author":"LS Vries de","year":"2010","unstructured":"de Vries LS, Groenendaal F (2010) Patterns of neonatal hypoxic\u2013ischaemic brain injury. Neuroradiology 52:555\u2013566","journal-title":"Neuroradiology"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1019-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1019-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1019-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T21:03:12Z","timestamp":1553547792000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1019-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["1019"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1019-7","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"14 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}