{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:58:12Z","timestamp":1769731092124,"version":"3.49.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS040408"],"award-info":[{"award-number":["NS040408"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s12035-018-1046-4","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T09:34:04Z","timestamp":1523352844000},"page":"9057-9074","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome"],"prefix":"10.1007","volume":"55","author":[{"given":"Kristen R.","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S. C.","family":"Louis Sam Titus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh R.","family":"D\u2019Mello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"1046_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/O10-112","volume":"89","author":"NL Adkins","year":"2011","unstructured":"Adkins NL, Georgel PT (2011) MeCP2: Structure and function. Biochem Cell Biol (Can) 89:1\u201311","journal-title":"Biochem Cell Biol (Can)"},{"key":"1046_CR2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1146\/annurev-cellbio-092910-154121","volume":"27","author":"J Guy","year":"2011","unstructured":"Guy J, Cheval H, Selfridge J, Bird A (2011) The role of MeCP2 in the brain. Annu Rev Cell Dev Biol (U S) 27:631\u2013652","journal-title":"Annu Rev Cell Dev Biol (U S)"},{"key":"1046_CR3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1139\/O08-115","volume":"87","author":"KC Hite","year":"2009","unstructured":"Hite KC, Adams VH, Hansen JC (2009) Recent advances in MeCP2 structure and function. Biochem Cell Biol (Can) 87:219\u2013227","journal-title":"Biochem Cell Biol (Can)"},{"key":"1046_CR4","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.molmed.2014.03.004","volume":"20","author":"J Ausio","year":"2014","unstructured":"Ausio J, Martinez de Paz A, Esteller M (2014) MeCP2: The long trip from a chromatin protein to neurological disorders. Trends Mol Med (Engl) 20:487\u2013498","journal-title":"Trends Mol Med (Engl)"},{"key":"1046_CR5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","volume":"56","author":"M Chahrour","year":"2007","unstructured":"Chahrour M, Zoghbi HY (2007) The story of rett syndrome: From clinic to neurobiology. Neuron (U S) 56:422\u2013437","journal-title":"Neuron (U S)"},{"key":"1046_CR6","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1172\/JCI78167","volume":"125","author":"LM Lombardi","year":"2015","unstructured":"Lombardi LM, Baker SA, Zoghbi HY (2015) MECP2 disorders: From the clinic to mice and back. J Clin Invest (U S) 125:2914\u20132923","journal-title":"J Clin Invest (U S)"},{"key":"1046_CR7","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1007\/s10803-013-1796-9","volume":"43","author":"SU Peters","year":"2013","unstructured":"Peters SU, Hundley RJ, Wilson AK, Carvalho CM, Lupski JR, Ramocki MB (2013) Brief report: Regression timing and associated features in MECP2 duplication syndrome. J Autism Dev Disord 43:2484\u20132490","journal-title":"J Autism Dev Disord"},{"key":"1046_CR8","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/ajmg.a.33184","volume":"152A","author":"MB Ramocki","year":"2010","unstructured":"Ramocki MB, Tavyev YJ, Peters SU (2010) The MECP2 duplication syndrome. Am J Med Genet A (U S) 152A:1079\u20131088","journal-title":"Am J Med Genet A (U S)"},{"key":"1046_CR9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000329580","volume":"2","author":"H Van Esch","year":"2012","unstructured":"Van Esch H (2012) MECP2 duplication syndrome. Mol Syndromol 2:128\u2013136","journal-title":"Mol Syndromol"},{"key":"1046_CR10","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1093\/hmg\/dds132","volume":"21","author":"B Tang","year":"2012","unstructured":"Tang B, Becanovic K, Desplats PA, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR et al (2012a) Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: Implications for transcriptional dysregulation in Huntington disease. Hum Mol Genet (Engl) 21:3097\u20133111","journal-title":"Hum Mol Genet (Engl)"},{"key":"1046_CR11","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/ejhg.2008.208","volume":"17","author":"D Lugtenberg","year":"2009","unstructured":"Lugtenberg D, Kleefstra T, Oudakker AR, Nillesen WM, Yntema HG, Tzschach A, Raynaud M, Rating D et al (2009) Structural variation in Xq28: MECP2 duplications in 1% of patients with unexplained XLMR and in 2% of male patients with severe encephalopathy. Eur J Hum Genet (Engl) 17:444\u2013453","journal-title":"Eur J Hum Genet (Engl)"},{"key":"1046_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.braindev.2012.07.010","volume":"35","author":"S Shimada","year":"2013","unstructured":"Shimada S, Okamoto N, Ito M, Arai Y, Momosaki K, Togawa M, Maegaki Y, Sugawara M et al (2013) MECP2 duplication syndrome in both genders. Brain Dev (Neth) 35:411\u2013419","journal-title":"Brain Dev (Neth)"},{"key":"1046_CR13","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1086\/444549","volume":"77","author":"H Van Esch","year":"2005","unstructured":"Van Esch H, Bauters M, Ignatius J, Jansen M, Raynaud M, Hollanders K, Lugtenberg D, Bienvenu T et al (2005) Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am J Hum Genet (U S) 77:442\u2013453","journal-title":"Am J Hum Genet (U S)"},{"key":"1046_CR14","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1093\/hmg\/ddh282","volume":"13","author":"AL Collins","year":"2004","unstructured":"Collins AL, Levenson JM, Vilaythong AP, Richman R, Armstrong DL, Noebels JL, David Sweatt J, Zoghbi HY (2004) Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet (Engl) 13:2679\u20132689","journal-title":"Hum Mol Genet (Engl)"},{"key":"1046_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4061\/2010\/573138","volume":"2010","author":"T Jaworski","year":"2010","unstructured":"Jaworski T, Kugler S, Van Leuven F (2010) Modeling of tau-mediated synaptic and neuronal degeneration in alzheimer's disease. Int J Alzheimers Dis (Engl) 2010:1\u201310. https:\/\/doi.org\/10.4061\/2010\/573138","journal-title":"Int J Alzheimers Dis (Engl)"},{"key":"1046_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007280","volume":"4","author":"T Jaworski","year":"2009","unstructured":"Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, Borghgraef P, Devijver H et al (2009) AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. PLoS One (U S) 4:e7280","journal-title":"PLoS One (U S)"},{"key":"1046_CR17","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/nm.3951","volume":"21","author":"SW Min","year":"2015","unstructured":"Min SW et al (2015) Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med (U S) 21:1154\u20131162","journal-title":"Nat Med (U S)"},{"key":"1046_CR18","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1523\/JNEUROSCI.3410-10.2011","volume":"31","author":"L Wang","year":"2011","unstructured":"Wang L, Colodner KJ, Feany MB (2011) Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an alexander disease model. J Neurosci (U S) 31:2868\u20132877","journal-title":"J Neurosci (U S)"},{"issue":"42","key":"1046_CR19","doi-asserted-by":"publisher","first-page":"35444","DOI":"10.1074\/jbc.M112.394544","volume":"287","author":"Farah H. Bardai","year":"2012","unstructured":"Bardai FH, Price V, Zaayman M, Wang L, D'Mello SR (2012) Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. J Biol Chem (U S) 287:35444\u201335453","journal-title":"Journal of Biological Chemistry"},{"issue":"29","key":"1046_CR20","doi-asserted-by":"publisher","first-page":"11833","DOI":"10.1523\/JNEUROSCI.5831-12.2013","volume":"33","author":"F. H. Bardai","year":"2013","unstructured":"Bardai FH, Verma P, Smith C, Rawat V, Wang L, D'Mello SR (2013) Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity. J Neurosci (U S) 33:11833\u201311838","journal-title":"Journal of Neuroscience"},{"key":"1046_CR21","doi-asserted-by":"publisher","first-page":"34569","DOI":"10.1074\/jbc.M114.576397","volume":"289","author":"J Norwood","year":"2014","unstructured":"Norwood J, Franklin JM, Sharma D, D'Mello SR (2014) Histone deacetylase 3 is necessary for proper brain development. J Biol Chem (U S) 289:34569\u201334582","journal-title":"J Biol Chem (U S)"},{"key":"1046_CR22","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/dneu.20637","volume":"68","author":"N Majdzadeh","year":"2008","unstructured":"Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D'Mello SR (2008) HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev Neurobiol (U S) 68:1076\u20131092","journal-title":"Dev Neurobiol (U S)"},{"key":"1046_CR23","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1111\/j.1460-9568.2008.06491.x","volume":"28","author":"HM Chen","year":"2008","unstructured":"Chen HM, Wang L, D'Mello SR (2008) A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci (Fr) 28:2003\u20132016","journal-title":"Eur J Neurosci (Fr)"},{"key":"1046_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ejpn.2011.07.011","volume":"16","author":"SS Tang","year":"2012","unstructured":"Tang SS, Fernandez D, Lazarou LP, Singh R, Fallon P (2012b) MECP2 triplication in 3 brothers - a rarely described cause of familial neurological regression in boys. Eur J Paediatr Neurol (Engl) 16:209\u2013212","journal-title":"Eur J Paediatr Neurol (Engl)"},{"key":"1046_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nrn2151","volume":"8","author":"BJ Molyneaux","year":"2007","unstructured":"Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD (2007) Neuronal subtype specification in the cerebral cortex. Nat Rev Neurosci (Engl) 8:427\u2013437","journal-title":"Nat Rev Neurosci (Engl)"},{"key":"1046_CR26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrn3886","volume":"16","author":"NL Cerminara","year":"2015","unstructured":"Cerminara NL, Lang EJ, Sillitoe RV, Apps R (2015) Redefining the cerebellar cortex as an assembly of non-uniform purkinje cell microcircuits. Nat Rev Neurosci (Engl) 16:79\u201393","journal-title":"Nat Rev Neurosci (Engl)"},{"key":"1046_CR27","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/ncpneuro0355","volume":"2","author":"NJ Maragakis","year":"2006","unstructured":"Maragakis NJ, Rothstein JD (2006) Mechanisms of disease: Astrocytes in neurodegenerative disease. Nat Clin Pract Neurol (Engl) 2:679\u2013689","journal-title":"Nat Clin Pract Neurol (Engl)"},{"key":"1046_CR28","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.nbd.2006.09.014","volume":"25","author":"LP Bjornsen","year":"2007","unstructured":"Bjornsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC (2007) Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures. Neurobiol Dis (U S) 25:319\u2013330","journal-title":"Neurobiol Dis (U S)"},{"key":"1046_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nn.4184","volume":"19","author":"S Robel","year":"2016","unstructured":"Robel S, Sontheimer H (2016) Glia as drivers of abnormal neuronal activity. Nat Neurosci (U S) 19:28\u201333","journal-title":"Nat Neurosci (U S)"},{"issue":"2","key":"1046_CR30","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.febslet.2012.11.033","volume":"587","author":"Chlo\u00e9 Del\u00e9pine","year":"2012","unstructured":"Del\u00e9pine C, Nectoux J, Bahi-Buisson N, Chelly J, Bienvenu T (2013) MeCP2 deficiency is associated with impaired microtubule stability. (Germany) FEBS Lett 587:245\u2013253","journal-title":"FEBS Letters"},{"issue":"5","key":"1046_CR31","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/jnr.23001","volume":"90","author":"Juliette Nectoux","year":"2012","unstructured":"Nectoux J, Florian C, Delepine C, Bahi-Buisson N, Khelfaoui M, Reibel S, Chelly J, Bienvenu T (2012) Altered microtubule dynamics in Mecp2-deficient astrocytes.J Neurosci Res (U S) 90:990\u2013998","journal-title":"Journal of Neuroscience Research"},{"key":"1046_CR32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s12035-011-8193-1","volume":"44","author":"K Papanikolopoulou","year":"2011","unstructured":"Papanikolopoulou K, Skoulakis EM (2011) The power and richness of modelling tauopathies in drosophila. Mol Neurobiol (U S) 44:122\u2013133","journal-title":"Mol Neurobiol (U S)"},{"key":"1046_CR33","doi-asserted-by":"publisher","first-page":"e2449","DOI":"10.1038\/cddis.2016.329","volume":"7","author":"XY Sun","year":"2016","unstructured":"Sun XY, Tuo QZ, Liuyang ZY, Xie AJ, Feng XL, Yan X, Qiu M, Li S et al (2016) Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell Death Dis (Engl) 7:e2449","journal-title":"Cell Death Dis (Engl)"},{"key":"1046_CR34","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1126\/science.1062382","volume":"293","author":"CW Wittmann","year":"2001","unstructured":"Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB (2001a) Tauopathy in drosophila: Neurodegeneration without neurofibrillary tangles. Science (U S) 293:711\u2013714","journal-title":"Science (U S)"},{"key":"1046_CR35","first-page":"e1687","volume":"118","author":"MJ Friez","year":"2006","unstructured":"Friez MJ, Jones JR, Clarkson K, Lubs H, Abuelo D, Bier JA, Pai S, Simensen R et al (2006) Recurrent infections, hypotonia, and mental retardation caused by duplication of MECP2 and adjacent region in Xq28. Pediatrics (U S) 118:e1687\u2013e1695","journal-title":"Pediatrics (U S)"},{"key":"1046_CR36","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/(SICI)1096-8628(19990730)85:3<243::AID-AJMG11>3.0.CO;2-E","volume":"85","author":"H Lubs","year":"1999","unstructured":"Lubs H, Abidi F, Bier JA, Abuelo D, Ouzts L, Voeller K, Fennell E, Stevenson RE et al (1999) XLMR syndrome characterized by multiple respiratory infections, hypertelorism, severe CNS deterioration and early death localizes to distal Xq28. Am J Med Genet (U S) 85:243\u2013248","journal-title":"Am J Med Genet (U S)"},{"key":"1046_CR37","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00431-010-1144-4","volume":"169","author":"W Reardon","year":"2010","unstructured":"Reardon W, Donoghue V, Murphy AM, King MD, Mayne PD, Horn N, Birk Moller L (2010) Progressive cerebellar degenerative changes in the severe mental retardation syndrome caused by duplication of MECP2 and adjacent loci on Xq28. Eur J Pediatr (Germany) 169:941\u2013949","journal-title":"Eur J Pediatr (Germany)"},{"key":"1046_CR38","doi-asserted-by":"publisher","first-page":"19518","DOI":"10.1523\/JNEUROSCI.1745-13.2013","volume":"33","author":"M Jiang","year":"2013","unstructured":"Jiang M, Ash RT, Baker SA, Suter B, Ferguson A, Park J, Rudy J, Torsky SP et al (2013) Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome. J Neurosci (U S) 33:19518\u201319533","journal-title":"J Neurosci (U S)"},{"key":"1046_CR39","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1093\/hmg\/ddp181","volume":"18","author":"S Ben-Shachar","year":"2009","unstructured":"Ben-Shachar S, Chahrour M, Thaller C, Shaw CA, Zoghbi HY (2009) Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus. Hum Mol Genet (Engl) 18:2431\u20132442","journal-title":"Hum Mol Genet (Engl)"},{"key":"1046_CR40","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1126\/science.1153252","volume":"320","author":"M Chahrour","year":"2008","unstructured":"Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (U S) 320:1224\u20131229","journal-title":"Science (U S)"},{"key":"1046_CR41","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/ng.1066","volume":"44","author":"RC Samaco","year":"2012","unstructured":"Samaco RC, Mandel-Brehm C, McGraw CM, Shaw CA, McGill BE, Zoghbi HY (2012) Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome. Nat Genet (U S) 44:206\u2013211","journal-title":"Nat Genet (U S)"},{"key":"1046_CR42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1474-4422(03)00301-6","volume":"2","author":"A Messing","year":"2003","unstructured":"Messing A, Brenner M (2003) Alexander disease: GFAP mutations unify young and old. Lancet Neurol (Engl) 2:75","journal-title":"Lancet Neurol (Engl)"},{"key":"1046_CR43","doi-asserted-by":"publisher","first-page":"5017","DOI":"10.1523\/JNEUROSCI.5384-11.2012","volume":"32","author":"A Messing","year":"2012","unstructured":"Messing A, Brenner M, Feany MB, Nedergaard M, Goldman JE (2012) Alexander disease. J Neurosci (U S) 32:5017\u20135023","journal-title":"J Neurosci (U S)"},{"key":"1046_CR44","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/j.1440-1789.2011.01268.x","volume":"32","author":"T Yoshida","year":"2012","unstructured":"Yoshida T, Nakagawa M (2012) Clinical aspects and pathology of alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation. Neuropathology (Aust) 32:440\u2013446","journal-title":"Neuropathology (Aust)"},{"key":"1046_CR45","doi-asserted-by":"publisher","first-page":"11162","DOI":"10.1523\/JNEUROSCI.3260-06.2006","volume":"26","author":"TL Hagemann","year":"2006","unstructured":"Hagemann TL, Connor JX, Messing A (2006) Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response. J Neurosci (U S) 26:11162\u201311173","journal-title":"J Neurosci (U S)"},{"key":"1046_CR46","volume":"5","author":"PL Jany","year":"2013","unstructured":"Jany PL, Hagemann TL, Messing A (2013) GFAP expression as an indicator of disease severity in mouse models of alexander disease. ASN Neuro (Engl) 5:e00109","journal-title":"ASN Neuro (Engl)"},{"key":"1046_CR47","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/glia.20486","volume":"55","author":"KF Tanaka","year":"2007","unstructured":"Tanaka KF, Takebayashi H, Yamazaki Y, Ono K, Naruse M, Iwasato T, Itohara S, Kato H et al (2007) Murine model of alexander disease: Analysis of GFAP aggregate formation and its pathological significance. Glia (U S) 55:617\u2013631","journal-title":"Glia (U S)"},{"key":"1046_CR48","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1002\/glia.22893","volume":"63","author":"HR Minkel","year":"2015","unstructured":"Minkel HR, Anwer TZ, Arps KM, Brenner M, Olsen ML (2015) Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II alexander disease. Glia (U S) 63:2285\u20132297","journal-title":"Glia (U S)"},{"key":"1046_CR49","doi-asserted-by":"publisher","first-page":"7439","DOI":"10.1523\/JNEUROSCI.4506-12.2013","volume":"33","author":"AA Sosunov","year":"2013","unstructured":"Sosunov AA, Guilfoyle E, Wu X, McKhann GM 2nd, Goldman JE (2013) Phenotypic conversions of \u201cprotoplasmic\u201d to \u201creactive\u201d astrocytes in alexander disease. J Neurosci (U S) 33:7439\u20137450","journal-title":"J Neurosci (U S)"},{"key":"1046_CR50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/NEN.0b013e3181d3cb52","volume":"69","author":"R Tian","year":"2010","unstructured":"Tian R, Wu X, Hagemann TL, Sosunov AA, Messing A, McKhann GM, Goldman JE (2010) Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes. J Neuropathol Exp Neurol (U S) 69:335\u2013345","journal-title":"J Neuropathol Exp Neurol (U S)"},{"key":"1046_CR51","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1083\/jcb.200908164","volume":"187","author":"H Ilieva","year":"2009","unstructured":"Ilieva H, Polymenidou M, Cleveland DW (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol (U S) 187:761\u2013772","journal-title":"J Cell Biol (U S)"},{"key":"1046_CR52","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.conb.2012.03.009","volume":"22","author":"JC McGann","year":"2012","unstructured":"McGann JC, Lioy DT, Mandel G (2012) Astrocytes conspire with neurons during progression of neurological disease. Curr Opin Neurobiol (Engl) 22:850\u2013858","journal-title":"Curr Opin Neurobiol (Engl)"},{"key":"1046_CR53","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.expneurol.2015.03.029","volume":"274","author":"M Sun","year":"2015","unstructured":"Sun M, Chen L (2015) Studying tauopathies in drosophila: A fruitful model. Exp Neurol 274:52\u201357","journal-title":"Exp Neurol"},{"key":"1046_CR54","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1111\/ejn.12251","volume":"37","author":"J Boehm","year":"2013","unstructured":"Boehm J (2013) A \u2018danse macabre\u2019: Tau and fyn in STEP with amyloid beta to facilitate induction of synaptic depression and excitotoxicity. Eur J Neurosci (Fr) 37:1925\u20131930","journal-title":"Eur J Neurosci (Fr)"},{"key":"1046_CR55","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1472-8206.1996.tb00585.x","volume":"10","author":"P Couratier","year":"1996","unstructured":"Couratier P, Lesort M, Terro F, Dussartre C, Hugon J (1996) NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures. Fundam Clin Pharmacol (Engl) 10:344\u2013349","journal-title":"Fundam Clin Pharmacol (Engl)"},{"key":"1046_CR56","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/(SICI)1097-4547(19970801)49:3<309::AID-JNR6>3.0.CO;2-G","volume":"49","author":"F Esclaire","year":"1997","unstructured":"Esclaire F, Lesort M, Blanchard C, Hugon J (1997) Glutamate toxicity enhances tau gene expression in neuronal cultures. J Neurosci Res (U S) 49:309\u2013318","journal-title":"J Neurosci Res (U S)"},{"key":"1046_CR57","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/0006-8993(92)90476-P","volume":"572","author":"P Sindou","year":"1992","unstructured":"Sindou P, Couratier P, Barthe D, Hugon J (1992) A dose-dependent increase of tau immunostaining is produced by glutamate toxicity in primary neuronal cultures. Brain Res (Neth) 572:242\u2013246","journal-title":"Brain Res (Neth)"},{"key":"1046_CR58","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1097\/00001756-199306000-00057","volume":"4","author":"M Pizzi","year":"1993","unstructured":"Pizzi M, Valerio A, Ribola M, Spano PF, Memo M (1993) A tau antisense oligonucleotide decreases neurone sensitivity to excitotoxic injury. Neuroreport (Engl) 4:823\u2013826","journal-title":"Neuroreport (Engl)"},{"key":"1046_CR59","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1111\/j.1460-9568.1995.tb01156.x","volume":"7","author":"M Pizzi","year":"1995","unstructured":"Pizzi M, Valerio A, Arrighi V, Galli P, Belloni M, Ribola M, Alberici A, Spano P et al (1995) Inhibition of glutamate-induced neurotoxicity by a tau antisense oligonucleotide in primary culture of rat cerebellar granule cells. Eur J Neurosci (Fr) 7:1603\u20131613","journal-title":"Eur J Neurosci (Fr)"},{"key":"1046_CR60","doi-asserted-by":"publisher","first-page":"e115765","DOI":"10.1371\/journal.pone.0115765","volume":"9","author":"JS Cheng","year":"2014","unstructured":"Cheng JS, Craft R, Yu GQ, Ho K, Wang X, Mohan G, Mangnitsky S, Ponnusamy R et al (2014) Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PLoS One (U S) 9:e115765","journal-title":"PLoS One (U S)"},{"key":"1046_CR61","volume":"2012","author":"YD Ke","year":"2012","unstructured":"Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J, Ittner A, Ittner LM (2012) Lessons from tau-deficient mice. Int J Alzheimers Dis (U S) 2012:873270","journal-title":"Int J Alzheimers Dis (U S)"},{"key":"1046_CR62","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.neuron.2011.04.009","volume":"70","author":"M Morris","year":"2011","unstructured":"Morris M, Maeda S, Vossel K, Mucke L (2011) The many faces of tau. Neuron (U S) 70:410\u2013426","journal-title":"Neuron (U S)"},{"key":"1046_CR63","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1126\/science.1141736","volume":"316","author":"ED Roberson","year":"2007","unstructured":"Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ et al (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an alzheimer's disease mouse model. Science (U S) 316:750\u2013754","journal-title":"Science (U S)"},{"key":"1046_CR64","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1523\/JNEUROSCI.2610-10.2011","volume":"31","author":"OA Shipton","year":"2011","unstructured":"Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP et al (2011) Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci (U S) 31:1688\u20131692","journal-title":"J Neurosci (U S)"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1046-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1046-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1046-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T20:15:00Z","timestamp":1660853700000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1046-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1046"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1046-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"assertion":[{"value":"20 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}