{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:36:14Z","timestamp":1771486574095,"version":"3.50.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["AUX-PE Toxinologia"],"award-info":[{"award-number":["AUX-PE Toxinologia"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["PUCRSINFRA # 01.11.0014-00"],"award-info":[{"award-number":["PUCRSINFRA # 01.11.0014-00"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s12035-018-1049-1","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T03:19:50Z","timestamp":1523935190000},"page":"9307-9327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis"],"prefix":"10.1007","volume":"55","author":[{"given":"Rodrigo B. M.","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Greggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianina T.","family":"Venturin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaderson C.","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus V.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"1049_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ejphar.2016.06.034","volume":"788","author":"LB Bergantin","year":"2016","unstructured":"Bergantin LB, Caricati-Neto A (2016) Challenges for the pharmacological treatment of neurological and psychiatric disorders: implications of the Ca(2+)\/cAMP intracellular signalling interaction. Eur J Pharmacol 788:255\u2013260. \n                    https:\/\/doi.org\/10.1016\/j.ejphar.2016.06.034","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"1049_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2012.06.001","volume":"99","author":"S Bhat","year":"2012","unstructured":"Bhat S, Dao DT, Terrillion CE, Arad M, Smith RJ, Soldatov NM, Gould TD (2012) CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog Neurobiol 99(1):1\u201314. \n                    https:\/\/doi.org\/10.1016\/j.pneurobio.2012.06.001","journal-title":"Prog Neurobiol"},{"issue":"1","key":"1049_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrd.2015.5","volume":"15","author":"GW Zamponi","year":"2016","unstructured":"Zamponi GW (2016) Targeting voltage-gated calcium channels in neurological and psychiatric diseases. Nat Rev Drug Discov 15(1):19\u201334. \n                    https:\/\/doi.org\/10.1038\/nrd.2015.5","journal-title":"Nat Rev Drug Discov"},{"key":"1049_CR4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neuropharm.2016.10.016","volume":"127","author":"E Bourinet","year":"2016","unstructured":"Bourinet E, Zamponi GW (2016) Block of voltage-gated calcium channels by peptide toxins. Neuropharmacology 127:109\u2013115. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2016.10.016","journal-title":"Neuropharmacology"},{"key":"1049_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00116","volume":"7","author":"BL Jones","year":"2016","unstructured":"Jones BL, Smith SM (2016) Calcium-sensing receptor: a key target for extracellular calcium signaling in neurons. Front Physiol 7:116. \n                    https:\/\/doi.org\/10.3389\/fphys.2016.00116","journal-title":"Front Physiol"},{"key":"1049_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejphar.2013.11.012","volume":"739","author":"S Chakroborty","year":"2014","unstructured":"Chakroborty S, Stutzmann GE (2014) Calcium channelopathies and Alzheimer's disease: insight into therapeutic success and failures. Eur J Pharmacol 739:83\u201395. \n                    https:\/\/doi.org\/10.1016\/j.ejphar.2013.11.012","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"1049_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1385\/NMM:8:3:307","volume":"8","author":"R Felix","year":"2006","unstructured":"Felix R (2006) Calcium channelopathies. NeuroMolecular Med 8(3):307\u2013318. \n                    https:\/\/doi.org\/10.1385\/NMM:8:3:307","journal-title":"NeuroMolecular Med"},{"issue":"2","key":"1049_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00441-013-1758-8","volume":"357","author":"R Fairless","year":"2014","unstructured":"Fairless R, Williams SK, Diem R (2014) Dysfunction of neuronal calcium signalling in neuroinflammation and neurodegeneration. Cell Tissue Res 357(2):455\u2013462. \n                    https:\/\/doi.org\/10.1007\/s00441-013-1758-8","journal-title":"Cell Tissue Res"},{"key":"1049_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0262-3","volume":"12","author":"SC Hopp","year":"2015","unstructured":"Hopp SC, D'Angelo HM, Royer SE, Kaercher RM, Crockett AM, Adzovic L, Wenk GL (2015) Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation. J Neuroinflammation 12:56. \n                    https:\/\/doi.org\/10.1186\/s12974-015-0262-3","journal-title":"J Neuroinflammation"},{"issue":"3","key":"1049_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091167","volume":"9","author":"BR Huang","year":"2014","unstructured":"Huang BR, Chang PC, Yeh WL, Lee CH, Tsai CF, Lin C, Lin HY, Liu YS et al (2014) Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One 9(3):e91167. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0091167","journal-title":"PLoS One"},{"issue":"1","key":"1049_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrneurol.2016.187","volume":"13","author":"T Olsson","year":"2017","unstructured":"Olsson T, Barcellos LF, Alfredsson L (2017) Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol 13(1):25\u201336 doi:nrneurol.2016.187","journal-title":"Nat Rev Neurol"},{"issue":"Suppl 1","key":"1049_CR12","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.msard.2016.07.003","volume":"9","author":"G Giovannoni","year":"2016","unstructured":"Giovannoni G, Butzkueven H, Dhib-Jalbut S, Hobart J, Kobelt G, Pepper G, Sormani MP, Thalheim C et al (2016) Brain health: time matters in multiple sclerosis. Mult Scler Relat Disord 9(Suppl 1):S5\u2013S48. \n                    https:\/\/doi.org\/10.1016\/j.msard.2016.07.003","journal-title":"Mult Scler Relat Disord"},{"issue":"12","key":"1049_CR13","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nrneurol.2016.171","volume":"12","author":"CA Dendrou","year":"2016","unstructured":"Dendrou CA, McVean G, Fugger L (2016) Neuroinflammation\u2014using big data to inform clinical practice. Nat Rev Neurol 12(12):685\u2013698. \n                    https:\/\/doi.org\/10.1038\/nrneurol.2016.171","journal-title":"Nat Rev Neurol"},{"issue":"1\u20132","key":"1049_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jns.2015.09.346","volume":"358","author":"M Farjam","year":"2015","unstructured":"Farjam M, Zhang GX, Ciric B, Rostami A (2015) Emerging immunopharmacological targets in multiple sclerosis. J Neurol Sci 358(1\u20132):22\u201330. \n                    https:\/\/doi.org\/10.1016\/j.jns.2015.09.346","journal-title":"J Neurol Sci"},{"issue":"12","key":"1049_CR15","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/nrneurol.2015.222","volume":"11","author":"G Mandolesi","year":"2015","unstructured":"Mandolesi G, Gentile A, Musella A, Fresegna D, De Vito F, Bullitta S, Sepman H, Marfia GA et al (2015) Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis. Nat Rev Neurol 11(12):711\u2013724. \n                    https:\/\/doi.org\/10.1038\/nrneurol.2015.222","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"1049_CR16","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.msard.2014.09.002","volume":"3","author":"K O'Connell","year":"2014","unstructured":"O'Connell K, Kelly SB, Fogarty E, Duggan M, Buckley L, Hutchinson M, McGuigan C, Tubridy N (2014) Economic costs associated with an MS relapse. Mult Scler Relat Disord 3(6):678\u2013683. \n                    https:\/\/doi.org\/10.1016\/j.msard.2014.09.002","journal-title":"Mult Scler Relat Disord"},{"key":"1049_CR17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s40273-016-0468-y","volume":"35","author":"J Oliva-Moreno","year":"2016","unstructured":"Oliva-Moreno J, Trapero-Bertran M, Pena-Longobardo LM, Del Pozo-Rubio R (2016) The valuation of informal care in cost-of-illness studies: a systematic review. PharmacoEconomics 35:331\u2013345. \n                    https:\/\/doi.org\/10.1007\/s40273-016-0468-y","journal-title":"PharmacoEconomics"},{"issue":"8","key":"1049_CR18","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.it.2013.04.006","volume":"34","author":"SB Simmons","year":"2013","unstructured":"Simmons SB, Pierson ER, Lee SY, Goverman JM (2013) Modeling the heterogeneity of multiple sclerosis in animals. Trends Immunol 34(8):410\u2013422. \n                    https:\/\/doi.org\/10.1016\/j.it.2013.04.006","journal-title":"Trends Immunol"},{"issue":"11","key":"1049_CR19","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nrd2358","volume":"7","author":"RS Lopez-Diego","year":"2008","unstructured":"Lopez-Diego RS, Weiner HL (2008) Novel therapeutic strategies for multiple sclerosis\u2014a multifaceted adversary. Nat Rev Drug Discov 7(11):909\u2013925. \n                    https:\/\/doi.org\/10.1038\/nrd2358","journal-title":"Nat Rev Drug Discov"},{"issue":"43","key":"1049_CR20","doi-asserted-by":"publisher","first-page":"33294","DOI":"10.1074\/jbc.M109.089805","volume":"285","author":"N Tokuhara","year":"2010","unstructured":"Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T et al (2010) N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis. J Biol Chem 285(43):33294\u201333306. \n                    https:\/\/doi.org\/10.1074\/jbc.M109.089805","journal-title":"J Biol Chem"},{"issue":"16","key":"1049_CR21","doi-asserted-by":"publisher","first-page":"E3295","DOI":"10.1073\/pnas.1620052114","volume":"114","author":"A Schampel","year":"2017","unstructured":"Schampel A, Volovitch O, Koeniger T, Scholz CJ, Jorg S, Linker RA, Wischmeyer E, Wunsch M et al (2017) Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. Proc Natl Acad Sci U S A 114(16):E3295\u2013E3304. \n                    https:\/\/doi.org\/10.1073\/pnas.1620052114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1049_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/toxins3010017","volume":"3","author":"E Pringos","year":"2011","unstructured":"Pringos E, Vignes M, Martinez J, Rolland V (2011) Peptide neurotoxins that affect voltage-gated calcium channels: a close-up on omega-agatoxins. Toxins (Basel) 3(1):17\u201342. \n                    https:\/\/doi.org\/10.3390\/toxins3010017","journal-title":"Toxins (Basel)"},{"key":"1049_CR23","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.addr.2015.04.025","volume":"90","author":"C Zhan","year":"2015","unstructured":"Zhan C, Li C, Wei X, Lu W (2015) Toxins and derivatives in molecular pharmaceutics: drug delivery and targeted therapy. Adv Drug Deliv Rev 90:101\u2013118. \n                    https:\/\/doi.org\/10.1016\/j.addr.2015.04.025","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"1049_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/bph.13652","volume":"174","author":"R Tonello","year":"2017","unstructured":"Tonello R, Fusi C, Materazzi S, Marone IM, De Logu F, Benemei S, Goncalves MC, Coppi E et al (2017) The peptide Phalpha1beta, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice. Br J Pharmacol 174(1):57\u201369. \n                    https:\/\/doi.org\/10.1111\/bph.13652","journal-title":"Br J Pharmacol"},{"issue":"5\u20136","key":"1049_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1023\/A:1021836403433","volume":"22","author":"MV Gomez","year":"2002","unstructured":"Gomez MV, Kalapothakis E, Guatimosim C, Prado MA (2002) Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels. Cell Mol Neurobiol 22(5\u20136):579\u2013588","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"1049_CR26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.jpain.2014.02.007","volume":"15","author":"R Tonello","year":"2014","unstructured":"Tonello R, Rigo F, Gewehr C, Trevisan G, Pereira EM, Gomez MV, Ferreira J (2014) Action of Phalpha1beta, a peptide from the venom of the spider Phoneutria nigriventer, on the analgesic and adverse effects caused by morphine in mice. J Pain 15(6):619\u2013631. \n                    https:\/\/doi.org\/10.1016\/j.jpain.2014.02.007","journal-title":"J Pain"},{"issue":"1","key":"1049_CR27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1213\/ANE.0000000000000249","volume":"119","author":"F Rosa","year":"2014","unstructured":"Rosa F, Trevisan G, Rigo FK, Tonello R, Andrade EL, Cordeiro Mdo N, Calixto JB, Gomez MV et al (2014) Phalpha1beta, a peptide from the venom of the spider Phoneutria nigriventer shows antinociceptive effects after continuous infusion in a neuropathic pain model in rats. Anesth Analg 119(1):196\u2013202. \n                    https:\/\/doi.org\/10.1213\/ANE.0000000000000249","journal-title":"Anesth Analg"},{"key":"1049_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.pbb.2014.09.017","volume":"126","author":"DM Diniz","year":"2014","unstructured":"Diniz DM, de Souza AH, Pereira EM, da Silva JF, Rigo FK, Romano-Silva MA, Binda N, Castro CJ Jr et al (2014) Effects of the calcium channel blockers Phalpha1beta and omega-conotoxin MVIIA on capsaicin and acetic acid-induced visceral nociception in mice. Pharmacol Biochem Behav 126:97\u2013102. \n                    https:\/\/doi.org\/10.1016\/j.pbb.2014.09.017","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"1049_CR29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/bph.12966","volume":"172","author":"RB Silva","year":"2015","unstructured":"Silva RB, Sperotto ND, Andrade EL, Pereira TC, Leite CE, de Souza AH, Bogo MR, Morrone FB et al (2015) Spinal blockage of P\/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172(3):924\u2013939. \n                    https:\/\/doi.org\/10.1111\/bph.12966","journal-title":"Br J Pharmacol"},{"key":"1049_CR30","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.toxicon.2017.02.001","volume":"129","author":"NF Nicoletti","year":"2017","unstructured":"Nicoletti NF, Erig TC, Zanin RF, Roxo MR, Ferreira NP, Gomez MV, Morrone FB, Campos MM (2017) Pre-clinical evaluation of voltage-gated calcium channel blockers derived from the spider P. nigriventer in glioma progression. Toxicon: Off J Int Soc Toxinology 129:58\u201367. \n                    https:\/\/doi.org\/10.1016\/j.toxicon.2017.02.001","journal-title":"Toxicon: Off J Int Soc Toxinology"},{"issue":"10","key":"1049_CR31","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.3390\/toxins7104175","volume":"7","author":"PJ Duggan","year":"2015","unstructured":"Duggan PJ, Tuck KL (2015) Bioactive mimetics of conotoxins and other venom peptides. Toxins (Basel) 7(10):4175\u20134198. \n                    https:\/\/doi.org\/10.3390\/toxins7104175","journal-title":"Toxins (Basel)"},{"issue":"3","key":"1049_CR32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.msard.2012.01.003","volume":"1","author":"S Amor","year":"2012","unstructured":"Amor S, Baker D (2012) Checklist for reporting and reviewing studies of experimental animal models of multiple sclerosis and related disorders. Mult Scler Relat Disord 1(3):111\u2013115. \n                    https:\/\/doi.org\/10.1016\/j.msard.2012.01.003","journal-title":"Mult Scler Relat Disord"},{"key":"1049_CR33","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.nbd.2013.02.007","volume":"54","author":"RC Dutra","year":"2013","unstructured":"Dutra RC, Bento AF, Leite DF, Manjavachi MN, Marcon R, Bicca MA, Pesquero JB, Calixto JB (2013) The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes. Neurobiol Dis 54:82\u201393. \n                    https:\/\/doi.org\/10.1016\/j.nbd.2013.02.007","journal-title":"Neurobiol Dis"},{"issue":"15","key":"1049_CR34","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1073\/pnas.1519960113","volume":"113","author":"K Thell","year":"2016","unstructured":"Thell K, Hellinger R, Sahin E, Michenthaler P, Gold-Binder M, Haider T, Kuttke M, Liutkeviciute Z et al (2016) Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A 113(15):3960\u20133965. \n                    https:\/\/doi.org\/10.1073\/pnas.1519960113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2\u20133","key":"1049_CR35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","volume":"67","author":"JL Hylden","year":"1980","unstructured":"Hylden JL, Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur J Pharmacol 67(2\u20133):313\u2013316 doi:0014\u20132999(80)90515\u20134","journal-title":"Eur J Pharmacol"},{"key":"1049_CR36","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.intimp.2015.11.024","volume":"30","author":"H Hou","year":"2016","unstructured":"Hou H, Cao R, Miao J, Sun Y, Liu X, Song X, Guo L (2016) Fingolimod ameliorates the development of experimental autoimmune encephalomyelitis by inhibiting Akt-mTOR axis in mice. Int Immunopharmacol 30:171\u2013178. \n                    https:\/\/doi.org\/10.1016\/j.intimp.2015.11.024","journal-title":"Int Immunopharmacol"},{"key":"1049_CR37","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.neuroscience.2014.07.065","volume":"277","author":"IS Maciel","year":"2014","unstructured":"Maciel IS, Azevedo VM, Pereira TC, Bogo MR, Souza AH, Gomez MV, Campos MM (2014) The spinal inhibition of N-type voltage-gated calcium channels selectively prevents scratching behavior in mice. Neuroscience 277:794\u2013805. \n                    https:\/\/doi.org\/10.1016\/j.neuroscience.2014.07.065","journal-title":"Neuroscience"},{"issue":"9","key":"1049_CR38","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.chembiol.2012.07.016","volume":"19","author":"J Quancard","year":"2012","unstructured":"Quancard J, Bollbuck B, Janser P, Angst D, Berst F, Buehlmayer P, Streiff M, Beerli C et al (2012) A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis. Chem Biol 19(9):1142\u20131151. \n                    https:\/\/doi.org\/10.1016\/j.chembiol.2012.07.016","journal-title":"Chem Biol"},{"issue":"11","key":"1049_CR39","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.1523\/JNEUROSCI.4389-07.2008","volume":"28","author":"NL Quintao","year":"2008","unstructured":"Quintao NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM, Calixto JB (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J Neurosci 28(11):2856\u20132863. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.4389-07.2008","journal-title":"J Neurosci"},{"issue":"13","key":"1049_CR40","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3969\/j.issn","volume":"7","author":"MG Tsagareli","year":"2012","unstructured":"Tsagareli MG, Tsiklauri N, Nozadze I, Gurtskaia G (2012) Tolerance effects of non-steroidal anti-inflammatory drugs microinjected into central amygdala, periaqueductal grey, and nucleus raphe: possible cellular mechanism. Neural Regen Res 7(13):1029\u20131039. \n                    https:\/\/doi.org\/10.3969\/j.issn","journal-title":"Neural Regen Res"},{"key":"1049_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbi.2013.06.002","volume":"33","author":"RC Dutra","year":"2013","unstructured":"Dutra RC, Moreira EL, Alberti TB, Marcon R, Prediger RD, Calixto JB (2013) Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system. Brain Behav Immun 33:90\u2013101. \n                    https:\/\/doi.org\/10.1016\/j.bbi.2013.06.002","journal-title":"Brain Behav Immun"},{"issue":"1","key":"1049_CR42","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbr.2009.06.005","volume":"204","author":"FL Assini","year":"2009","unstructured":"Assini FL, Duzzioni M, Takahashi RN (2009) Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation. Behav Brain Res 204(1):206\u2013211. \n                    https:\/\/doi.org\/10.1016\/j.bbr.2009.06.005","journal-title":"Behav Brain Res"},{"issue":"2","key":"1049_CR43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/sj.bjp.0706327","volume":"146","author":"ES Fernandes","year":"2005","unstructured":"Fernandes ES, Passos GF, Campos MM, de Souza GE, Fittipaldi JF, Pesquero JL, Teixeira MM, Calixto JB (2005) Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression. Br J Pharmacol 146(2):209\u2013216. \n                    https:\/\/doi.org\/10.1038\/sj.bjp.0706327","journal-title":"Br J Pharmacol"},{"issue":"3","key":"1049_CR44","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.4049\/jimmunol.178.3.1791","volume":"178","author":"J Ochoa-Reparaz","year":"2007","unstructured":"Ochoa-Reparaz J, Riccardi C, Rynda A, Jun S, Callis G, Pascual DW (2007) Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis. J Immunol 178(3):1791\u20131799","journal-title":"J Immunol"},{"issue":"1","key":"1049_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008720","volume":"5","author":"A Rynda","year":"2010","unstructured":"Rynda A, Maddaloni M, Ochoa-Reparaz J, Callis G, Pascual DW (2010) IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE). PLoS One 5(1):e8720. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0008720","journal-title":"PLoS One"},{"key":"1049_CR46","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jnutbio.2015.09.007","volume":"27","author":"RD Freitas","year":"2016","unstructured":"Freitas RD, Costa KM, Nicoletti NF, Kist LW, Bogo MR, Campos MM (2016) Omega-3 fatty acids are able to modulate the painful symptoms associated to cyclophosphamide-induced-hemorrhagic cystitis in mice. J Nutr Biochem 27:219\u2013232. \n                    https:\/\/doi.org\/10.1016\/j.jnutbio.2015.09.007","journal-title":"J Nutr Biochem"},{"issue":"6","key":"1049_CR47","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1073\/pnas.0610544104","volume":"104","author":"CG Radu","year":"2007","unstructured":"Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON (2007) Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 104(6):1937\u20131942. \n                    https:\/\/doi.org\/10.1073\/pnas.0610544104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1049_CR48","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s11064-015-1576-3","volume":"40","author":"PP Baptista","year":"2015","unstructured":"Baptista PP, Saur L, Bagatini PB, Greggio S, Venturin GT, Vaz SP, Ferreira Kdos R, Junqueira JS et al (2015) Antidepressant effects of ketamine are not related to (1)(8)F-FDG metabolism or tyrosine hydroxylase immunoreactivity in the ventral tegmental area of Wistar rats. Neurochem Res 40(6):1153\u20131164. \n                    https:\/\/doi.org\/10.1007\/s11064-015-1576-3","journal-title":"Neurochem Res"},{"issue":"12","key":"1049_CR49","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","volume":"7","author":"ND Chiaravalloti","year":"2008","unstructured":"Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. The Lancet Neurology 7(12):1139\u20131151. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(08)70259-X","journal-title":"The Lancet Neurology"},{"key":"1049_CR50","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.intimp.2015.11.024","volume":"30","author":"H Hou","year":"2016","unstructured":"Hou H, Cao R, Miao J, Sun Y, Liu X, Song X, Guo L (2016) Fingolimod ameliorates the development of experimental autoimmune encephalomyelitis by inhibiting Akt-mTOR axis in mice. Int Immunopharmacol 30:171\u2013178. \n                    https:\/\/doi.org\/10.1016\/j.intimp.2015.11.024","journal-title":"Int Immunopharmacol"},{"key":"1049_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00104","volume":"8","author":"RM Cassidy","year":"2017","unstructured":"Cassidy RM, Tong Q (2017) Hunger and satiety gauge reward sensitivity. Front Endocrinol 8:104. \n                    https:\/\/doi.org\/10.3389\/fendo.2017.00104","journal-title":"Front Endocrinol"},{"issue":"2","key":"1049_CR52","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.cyto.2015.04.004","volume":"75","author":"J Hutcheson","year":"2015","unstructured":"Hutcheson J (2015) Adipokines influence the inflammatory balance in autoimmunity. Cytokine 75(2):272\u2013279. \n                    https:\/\/doi.org\/10.1016\/j.cyto.2015.04.004","journal-title":"Cytokine"},{"issue":"2","key":"1049_CR53","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1136\/jnnp-2016-313300","volume":"88","author":"I Kawachi","year":"2017","unstructured":"Kawachi I, Lassmann H (2017) Neurodegeneration in multiple sclerosis and neuromyelitis optica. J Neurol Neurosurg Psychiatry 88(2):137\u2013145. \n                    https:\/\/doi.org\/10.1136\/jnnp-2016-313300","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1049_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00071","volume":"4","author":"HS Domingues","year":"2016","unstructured":"Domingues HS, Portugal CC, Socodato R, Relvas JB (2016) Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair. Frontiers Cell Dev Biol 4:71. \n                    https:\/\/doi.org\/10.3389\/fcell.2016.00071","journal-title":"Frontiers Cell Dev Biol"},{"issue":"1","key":"1049_CR55","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12974-016-0678-4","volume":"13","author":"N Sinmaz","year":"2016","unstructured":"Sinmaz N, Nguyen T, Tea F, Dale RC, Brilot F (2016) Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system. J Neuroinflammation 13(1):219. \n                    https:\/\/doi.org\/10.1186\/s12974-016-0678-4","journal-title":"J Neuroinflammation"},{"issue":"4","key":"1049_CR56","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.arr.2013.05.008","volume":"12","author":"DM Sama","year":"2013","unstructured":"Sama DM, Norris CM (2013) Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction. Ageing Res Rev 12(4):982\u2013995. \n                    https:\/\/doi.org\/10.1016\/j.arr.2013.05.008","journal-title":"Ageing Res Rev"},{"key":"1049_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00168","volume":"4","author":"DH Tian","year":"2013","unstructured":"Tian DH, Perera CJ, Apostolopoulos V, Moalem-Taylor G (2013) Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Front Neurol 4:168. \n                    https:\/\/doi.org\/10.3389\/fneur.2013.00168","journal-title":"Front Neurol"},{"key":"1049_CR58","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.lfs.2017.06.018","volume":"182","author":"MR Palhares","year":"2017","unstructured":"Palhares MR, Silva JF, Rezende MJS, Santos DC, Silva-Junior CA, Borges MH, Ferreira J, Gomez MV et al (2017) Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mice. Life Sci 182:122\u2013128. \n                    https:\/\/doi.org\/10.1016\/j.lfs.2017.06.018","journal-title":"Life Sci"},{"issue":"9","key":"1049_CR59","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1111\/cas.12209","volume":"104","author":"FK Rigo","year":"2013","unstructured":"Rigo FK, Trevisan G, Rosa F, Dalmolin GD, Otuki MF, Cueto AP, de Castro Junior CJ, Romano-Silva MA et al (2013) Spider peptide Phalpha1beta induces analgesic effect in a model of cancer pain. Cancer Sci 104(9):1226\u20131230. \n                    https:\/\/doi.org\/10.1111\/cas.12209","journal-title":"Cancer Sci"},{"issue":"12","key":"1049_CR60","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1111\/bph.13930","volume":"175","author":"Nian Gong","year":"2017","unstructured":"Gong N, Park J, Luo ZD (2017) Injury-induced maladaptation and dysregulation of calcium channel alpha2 delta subunit proteins and its contribution to neuropathic pain development. Br J Pharmacol. \n                    https:\/\/doi.org\/10.1111\/bph.13930","journal-title":"British Journal of Pharmacology"},{"issue":"10","key":"1049_CR61","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.it.2016.08.001","volume":"37","author":"M Schwartz","year":"2016","unstructured":"Schwartz M, Deczkowska A (2016) Neurological disease as a failure of brain-immune crosstalk: the multiple faces of neuroinflammation. Trends Immunol 37(10):668\u2013679. \n                    https:\/\/doi.org\/10.1016\/j.it.2016.08.001","journal-title":"Trends Immunol"},{"key":"1049_CR62","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/ane.12650","volume":"134 Suppl 200","author":"P Hamalainen","year":"2016","unstructured":"Hamalainen P, Rosti-Otajarvi E (2016) Cognitive impairment in MS: rehabilitation approaches. Acta Neurol Scand 134 Suppl 200:8\u201313. \n                    https:\/\/doi.org\/10.1111\/ane.12650","journal-title":"Acta Neurol Scand"},{"key":"1049_CR63","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008427.pub3","volume":"4","author":"C Payne","year":"2017","unstructured":"Payne C, Wiffen PJ, Martin S (2017) WITHDRAWN: interventions for fatigue and weight loss in adults with advanced progressive illness. Cochrane Database Syst Rev 4:CD008427. \n                    https:\/\/doi.org\/10.1002\/14651858.CD008427.pub3","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"1049_CR64","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3109\/08820139.2016.1157811","volume":"45","author":"M Farrokhi","year":"2016","unstructured":"Farrokhi M, Dabirzadeh M, Fadaee E, Beni AA, Saadatpour Z, Rezaei A, Heidari Z (2016) Polymorphism in leptin and leptin receptor genes may modify leptin levels and represent risk factors for multiple sclerosis. Immunol Investig 45(4):328\u2013335. \n                    https:\/\/doi.org\/10.3109\/08820139.2016.1157811","journal-title":"Immunol Investig"},{"issue":"2","key":"1049_CR65","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.molmed.2015.12.001","volume":"22","author":"C Naylor","year":"2016","unstructured":"Naylor C, Petri WA Jr (2016) Leptin regulation of immune responses. Trends Mol Med 22(2):88\u201398. \n                    https:\/\/doi.org\/10.1016\/j.molmed.2015.12.001","journal-title":"Trends Mol Med"},{"issue":"1","key":"1049_CR66","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nri.2016.123","volume":"17","author":"B Becher","year":"2017","unstructured":"Becher B, Spath S, Goverman J (2017) Cytokine networks in neuroinflammation. Nat Rev Immunol 17(1):49\u201359. \n                    https:\/\/doi.org\/10.1038\/nri.2016.123","journal-title":"Nat Rev Immunol"},{"key":"1049_CR67","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jneuroim.2017.01.001","volume":"308","author":"S Perlman","year":"2017","unstructured":"Perlman S, Zhao J (2017) Roles of regulatory T cells and IL-10 in virus-induced demyelination. J Neuroimmunol 308:6\u201311. \n                    https:\/\/doi.org\/10.1016\/j.jneuroim.2017.01.001","journal-title":"J Neuroimmunol"},{"key":"1049_CR68","doi-asserted-by":"publisher","unstructured":"Balasa RI, Mihaela S, Voidazan S, Barcutean LI, Bajko Z, Hutanu A, Simu I, Maier S (2017) Natalizumab changes the peripheral profile of the Th17 panel in Ms patients: new mechanisms of action. CNS & neurological disorders drug targets. doi:\n                    https:\/\/doi.org\/10.2174\/1871527316666170807130632","DOI":"10.2174\/1871527316666170807130632"},{"key":"1049_CR69","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.2147\/NDT.S140634","volume":"13","author":"C Luo","year":"2017","unstructured":"Luo C, Jian C, Liao Y, Huang Q, Wu Y, Liu X, Zou D, Wu Y (2017) The role of microglia in multiple sclerosis. Neuropsychiatr Dis Treat 13:1661\u20131667. \n                    https:\/\/doi.org\/10.2147\/NDT.S140634","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"8","key":"1049_CR70","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.2967\/jnumed.111.102608","volume":"53","author":"D Buck","year":"2012","unstructured":"Buck D, Forschler A, Lapa C, Schuster T, Vollmar P, Korn T, Nessler S, Stadelmann C et al (2012) 18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions. J Nucl Med: Off Publ Soc Nucl Med 53(8):1269\u20131276. \n                    https:\/\/doi.org\/10.2967\/jnumed.111.102608","journal-title":"J Nucl Med: Off Publ Soc Nucl Med"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1049-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1049-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1049-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T20:24:25Z","timestamp":1555446265000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1049-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1049"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1049-1","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"1 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experimental procedures complied with the National Institutes of Health Animal Care Guidelines (NIH publications n\u00b0 80-23), and were approved by the Animal Ethics Committee of the Pontifical Catholic University of Rio Grande do Sul (PUCRS, Porto Alegre, Brazil) (protocol number 14\/00424).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}