{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:36:14Z","timestamp":1790627774992,"version":"4.1.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Japan Society for the Promotion of Science and Core-to-Core Program, LISA Carnot institute, National Institute of Applied Sciences-Lyon and the French Ministry of Education and Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s12035-018-1139-0","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T09:52:50Z","timestamp":1527846770000},"page":"986-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Targeting the Brain with a Neuroprotective Omega-3 Fatty Acid to Enhance Neurogenesis in Hypoxic Condition in Culture"],"prefix":"10.1007","volume":"56","author":[{"given":"Amanda","family":"Lo Van","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Sakayori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayssa","family":"Hachem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounir","family":"Belkouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Picq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Fourmaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lagarde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Osumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-5983","authenticated-orcid":false,"given":"Nathalie","family":"Bernoud-Hubac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"issue":"9356","key":"1139_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0140-6736(03)12468-3","volume":"361","author":"Frank Thies","year":"2003","unstructured":"Thies F, Garry JMC, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, et al. (2003) Mechanisms of disease association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 361:477\u2013485 . doi: \nhttps:\/\/doi.org\/10.1016\/S0140-6736(03)12468-3","journal-title":"The Lancet"},{"key":"1139_CR2","doi-asserted-by":"crossref","unstructured":"Colussi G, Catena C, Dialti V, Mos L, Sechi AL (2014) Effects of the consumption of fish meals on the carotid intimamedia thickness in patients with hypertension: a prospective study. J Atheroscler Thromb 941\u2013956 . doi: DN\/JST.JSTAGE\/jat\/22921 [pii]","DOI":"10.5551\/jat.22921"},{"key":"1139_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.bbalip.2009.01.012","volume":"1791","author":"M Hashimoto","year":"2009","unstructured":"Hashimoto M, Shahdat HM, Katakura M, Tanabe Y, Gamoh S, Miwa K, Shimada T, Shido O (2009) Effects of docosahexaenoic acid on in vitro amyloid beta peptide 25-35 fibrillation. Biochim Biophys Acta 1791:289\u2013296. \nhttps:\/\/doi.org\/10.1016\/j.bbalip.2009.01.012","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"1139_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2174\/156720211795495349","volume":"8","author":"Fabien Chauveau","year":"2011","unstructured":"Chauveau F, Cho T-H, Perez M, Guichardant M, Riou A, Aguettaz P, Picq M, Lagarde M, et al. (2011) Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. Curr Neurovasc Res 8:95\u2013102 . doi: \nhttps:\/\/doi.org\/10.2174\/156720211795495349","journal-title":"Current Neurovascular Research"},{"key":"1139_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1051\/rnd:2005001","volume":"45","author":"G Young","year":"2005","unstructured":"Young G, Conquer J (2005) Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev 45:1\u201328","journal-title":"Reprod Nutr Dev"},{"key":"1139_CR6","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2165\/00003495-200565080-00002","volume":"65","author":"M Peet","year":"2005","unstructured":"Peet M, Stokes C (2005) Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs 65:1051\u20131059","journal-title":"Drugs"},{"key":"1139_CR7","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1093\/ajcn\/86.5.1486","volume":"86","author":"X Gao","year":"2007","unstructured":"Gao X, Chen H, Fung TT, Logroscino G, Schwarzschild MA, Hu FB, Ascherio A (2007) Prospective study of dietary pattern and risk of Parkinson disease. Am J Clin Nutr 86:1486\u20131494","journal-title":"Am J Clin Nutr"},{"key":"1139_CR8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1161\/01.STR.0000149620.74770.2e","volume":"36","author":"L Belayev","year":"2005","unstructured":"Belayev L, Marcheselli VL, Khoutorova L, Rodriguez de Turco EB, Busto R, Ginsberg MD, Bazan NG (2005) Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke 36:118\u2013123. \nhttps:\/\/doi.org\/10.1161\/01.STR.0000149620.74770.2e","journal-title":"Stroke"},{"key":"1139_CR9","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1161\/STROKEAHA.109.555979","volume":"40","author":"L Belayev","year":"2009","unstructured":"Belayev L, Khoutorova L, Atkins KD, Bazan NG (2009) Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke 40:3121\u20133126. \nhttps:\/\/doi.org\/10.1161\/STROKEAHA.109.555979","journal-title":"Stroke"},{"key":"1139_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.pestbp.2011.02.012.Investigations","volume":"338","author":"S-H Hong","year":"2014","unstructured":"Hong S-H, Belayev L, Khoutorova L, Obenaus A, Bazan NG (2014) Docosahexaenoic acid confers enduring neuroprotection in experimental stroke. J Neurol Sci 338:135\u2013141. \nhttps:\/\/doi.org\/10.1016\/j.pestbp.2011.02.012.Investigations","journal-title":"J Neurol Sci"},{"key":"1139_CR11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.plefa.2007.10.019","volume":"77","author":"F Calon","year":"2007","unstructured":"Calon F, Cole G (2007) Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot Essent Fatty Acids 77:287\u2013293. \nhttps:\/\/doi.org\/10.1016\/j.plefa.2007.10.019","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1139_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.plefa.2009.01.004","volume":"80","author":"JT Brenna","year":"2009","unstructured":"Brenna JT, Salem N, Sinclair AJ, Cunnane SC (2009) Alpha-linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fat Acids 80:85\u201391. \nhttps:\/\/doi.org\/10.1016\/j.plefa.2009.01.004","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"1139_CR13","first-page":"R1273","volume":"267","author":"F Thies","year":"1994","unstructured":"Thies F, Pillon C, Moliere P, Lagarde M, Lecerf J (1994) Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. Am J Phys 267:R1273\u2013R1279","journal-title":"Am J Phys"},{"key":"1139_CR14","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1046\/j.1471-4159.1999.0720338.x","volume":"72","author":"N Bernoud","year":"1999","unstructured":"Bernoud N, Fenart L, Moli\u00e8re P, Dehouck MP, Lagarde M, Cecchelli R, Lecerf J (1999) Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid. J Neurochem 72:338\u2013345. \nhttps:\/\/doi.org\/10.1046\/j.1471-4159.1999.0720338.x","journal-title":"J Neurochem"},{"key":"1139_CR15","first-page":"173","volume":"88","author":"M Lagarde","year":"2001","unstructured":"Lagarde M, Bernoud N, Thies F, Brossard N, Lemaitre-Delaunay D, Croset M, Lecerf J (2001) Lysophosphatidylcholine as a carrier of docosahexaenoic acid to target tissues. J Mol Neurosci 88:173\u2013177","journal-title":"J Mol Neurosci"},{"issue":"7501","key":"1139_CR16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature13241","volume":"509","author":"Long N. Nguyen","year":"2014","unstructured":"Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh ELK, et al. (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509:503\u2013506 . doi: \nhttps:\/\/doi.org\/10.1038\/nature13241","journal-title":"Nature"},{"key":"1139_CR17","doi-asserted-by":"publisher","first-page":"9383","DOI":"10.1074\/jbc.M116.721035","volume":"291","author":"DQY Quek","year":"2016","unstructured":"Quek DQY, Nguyen LN, Fan H, Silver DL (2016) Structural insights into the transport mechanism of the human sodium-dependent Lysophosphatidylcholine transporter MFSD2A. J Biol Chem 291:9383\u20139394. \nhttps:\/\/doi.org\/10.1074\/jbc.M116.721035","journal-title":"J Biol Chem"},{"key":"1139_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-11766-0","volume":"7","author":"D Sugasini","year":"2017","unstructured":"Sugasini D, Thomas R, Yalagala PCR, Tai LM, Subbaiah PV (2017) Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice. Sci Rep 7:1\u201311. \nhttps:\/\/doi.org\/10.1038\/s41598-017-11766-0","journal-title":"Sci Rep"},{"issue":"5","key":"1139_CR19","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1007\/s12035-015-9228-9","volume":"53","author":"Mayssa Hachem","year":"2015","unstructured":"Hachem M, G\u00e9lo\u00ebn A, Lo Van A, Fourmaux B, Fenart L, Gosselet F, Da Silva P, Breton G, et al. (2016) Efficient docosahexaenoic acid uptake by the brain from a structured phospholipid. Mol Neurobiol 53:3205\u20133215. doi: \nhttps:\/\/doi.org\/10.1007\/s12035-015-9228-9","journal-title":"Molecular Neurobiology"},{"key":"1139_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.plefa.2014.01.005","volume":"92","author":"M Lagarde","year":"2015","unstructured":"Lagarde M, Hachem M, Bernoud-Hubac N, Picq M, V\u00e9ricel E, Guichardant M (2015) Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain. Prostaglandins Leukot Essent Fat Acids 92:63\u201365. \nhttps:\/\/doi.org\/10.1016\/j.plefa.2014.01.005","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"1139_CR21","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.1523\/JNEUROSCI.13-08-03510.1993","volume":"13","author":"M Goldberg","year":"1993","unstructured":"Goldberg M, Choi W (1993) Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci 13:3510\u20133524","journal-title":"J Neurosci"},{"issue":"5","key":"1139_CR22","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1523\/JNEUROSCI.4043-13.2014","volume":"34","author":"M. Zhang","year":"2014","unstructured":"Zhang M, Wang S, Mao L, Leak RK, Shi Y, Zhang W, Hu X, Sun B, et al. (2014) Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. J Neurosci 34:1903\u20131915 . doi: \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.4043-13.2014","journal-title":"Journal of Neuroscience"},{"key":"1139_CR23","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.biochi.2016.07.011","volume":"130","author":"A Lo Van","year":"2016","unstructured":"Lo Van A, Sakayori N, Hachem M, Belkouch M, Picq M, Lagarde M, Osumi N, Bernoud-Hubac N (2016) Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases. Biochimie 130:163\u2013167. \nhttps:\/\/doi.org\/10.1016\/j.biochi.2016.07.011","journal-title":"Biochimie"},{"key":"1139_CR24","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.bbalip.2010.08.002","volume":"1801","author":"G Bannenberg","year":"2010","unstructured":"Bannenberg G, Serhan CN (2010) Specialized pro-resolving lipid mediators in the inflammatory response: an update. Biochim Biophys Acta 1801:1260\u20131273. \nhttps:\/\/doi.org\/10.1016\/j.bbalip.2010.08.002","journal-title":"Biochim Biophys Acta"},{"key":"1139_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","volume":"19","author":"M Spite","year":"2014","unstructured":"Spite M, Cl\u00e0ria J, Serhan CN (2014) Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab 19:21\u201336. \nhttps:\/\/doi.org\/10.1016\/j.cmet.2013.10.006","journal-title":"Cell Metab"},{"key":"1139_CR26","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1016\/j.febslet.2009.10.004","volume":"583","author":"P Chen","year":"2009","unstructured":"Chen P, Fenet B, Michaud S, Tomczyk N, V\u00e9ricel E, Lagarde M, Guichardant M (2009) Full characterization of PDX, a neuroprotectin\/protectin D1 isomer, which inhibits blood platelet aggregation. FEBS Lett 583:3478\u20133484. \nhttps:\/\/doi.org\/10.1016\/j.febslet.2009.10.004","journal-title":"FEBS Lett"},{"key":"1139_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1196\/annals.1344.011","volume":"1053","author":"NG Bazan","year":"2005","unstructured":"Bazan NG, Marcheselli VL, Cole-Edwards K (2005) Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Ann N Y Acad Sci 1053:137\u2013147. \nhttps:\/\/doi.org\/10.1196\/annals.1344.011","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"1139_CR28","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.4049\/jimmunol.176.3.1848","volume":"176","author":"Charles N. Serhan","year":"2006","unstructured":"Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, et al. (2006) Anti-inflammatory actions of neuroprotectin D1\/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol 176:1848\u20131859","journal-title":"The Journal of Immunology"},{"key":"1139_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.plefa.2010.02.003","volume":"82","author":"BD Levy","year":"2010","unstructured":"Levy BD (2010) Resolvins and protectins: natural pharmacophores for resolution biology. Prostaglandins Leukot Essent Fatty Acids 82:327\u2013332. \nhttps:\/\/doi.org\/10.1016\/j.plefa.2010.02.003","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1139_CR30","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1096\/fj.10-161836","volume":"25","author":"P Chen","year":"2011","unstructured":"Chen P, V\u00e9ricel E, Lagarde M, Guichardant M (2011) Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. FASEB J 25:382\u2013388. \nhttps:\/\/doi.org\/10.1096\/fj.10-161836","journal-title":"FASEB J"},{"key":"1139_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11745-013-3863-6","volume":"49","author":"M Liu","year":"2014","unstructured":"Liu M, Boussetta T, Makni-Maalej K, Fay M, Driss F, El-Benna J, Lagarde M, Guichardant M (2014) Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. Lipids 49:49\u201357. \nhttps:\/\/doi.org\/10.1007\/s11745-013-3863-6","journal-title":"Lipids"},{"key":"1139_CR32","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1159\/000381474.A","volume":"53","author":"M Zhu","year":"2016","unstructured":"Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm A-C, Serhan CN, Schultzberg M (2016) Pro-resolving lipid mediators improve neuronal survival and increase A\u03b242 phagocytosis. Mol Neurobiol 53:2733\u20132749. \nhttps:\/\/doi.org\/10.1159\/000381474.A","journal-title":"Mol Neurobiol"},{"key":"1139_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-01603-9","volume":"7","author":"TW Jung","year":"2017","unstructured":"Jung TW, Kim HC, Abd El-Aty AM, Jeong JH (2017) Protectin DX ameliorates palmitate-or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPAR\u03b1-dependent pathway in mice. Sci Rep 7:1\u20139. \nhttps:\/\/doi.org\/10.1038\/s41598-017-01603-9","journal-title":"Sci Rep"},{"key":"1139_CR34","doi-asserted-by":"publisher","first-page":"S199","DOI":"10.1007\/BF02637076","volume":"31","author":"LL Holte","year":"1996","unstructured":"Holte LL, Separovic F, Gawrisch K (1996) Nuclear magnetic resonance investigation of hydrocarbon chain packing in bilayers of polyunsaturated phospholipids. Lipids 31:S199\u2013S203","journal-title":"Lipids"},{"key":"1139_CR35","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0304-4157(84)90005-4","volume":"779","author":"CD Stubbs","year":"1984","unstructured":"Stubbs CD, Smith AD (1984) The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta 779:89\u2013137","journal-title":"Biochim Biophys Acta"},{"key":"1139_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-006-0164-x","volume":"293","author":"M Hashimoto","year":"2006","unstructured":"Hashimoto M, Hossain S, Shido O (2006) Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. Mol Cell Biochem 293:1\u20138","journal-title":"Mol Cell Biochem"},{"key":"1139_CR37","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/(SICI)1097-4547(19990615)56:6<565::AID-JNR2>3.0.CO;2-H","volume":"56","author":"S Yehuda","year":"1999","unstructured":"Yehuda S, Rabinovitz S, Mostofsky DI (1999) Essential fatty acids are mediators of brain biochemistry and cognitive functions. J Neurosci Res 56:565\u2013570","journal-title":"J Neurosci Res"},{"key":"1139_CR38","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.plefa.2003.12.011","volume":"70","author":"LA Horrocks","year":"2004","unstructured":"Horrocks LA, Farooqui AA (2004) Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukot Essent Fatty Acids 70:361\u2013372","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1139_CR39","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/j.1365-2443.2011.01527.x","volume":"16","author":"N Sakayori","year":"2011","unstructured":"Sakayori N, Maekawa M, Numayama-Tsuruta K, Katura T, Moriya T, Osumi N (2011) Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem\/progenitor cells. Genes Cells 16:778\u2013790. \nhttps:\/\/doi.org\/10.1111\/j.1365-2443.2011.01527.x","journal-title":"Genes Cells"},{"key":"1139_CR40","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001.Adult","volume":"70","author":"G Ming","year":"2011","unstructured":"Ming G, Song H (2011) Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70:687\u2013702. \nhttps:\/\/doi.org\/10.1016\/j.neuron.2011.05.001.Adult","journal-title":"Neuron"},{"key":"1139_CR41","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1098\/rstb.2006.1887","volume":"361","author":"U Shivraj Sohur","year":"2006","unstructured":"Shivraj Sohur U, Emsley JG, Mitchell BD, Macklis JD (2006) Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells. Philos Trans R Soc B Biol Sci 361:1477\u20131497. \nhttps:\/\/doi.org\/10.1098\/rstb.2006.1887","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"1139_CR42","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.neuroscience.2006.01.021","volume":"139","author":"E Kawakita","year":"2006","unstructured":"Kawakita E, Hashimoto M, Shido O (2006) Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 139:991\u2013997. \nhttps:\/\/doi.org\/10.1016\/j.neuroscience.2006.01.021","journal-title":"Neuroscience"},{"key":"1139_CR43","doi-asserted-by":"publisher","first-page":"11370","DOI":"10.1073\/pnas.0904835106","volume":"106","author":"C He","year":"2009","unstructured":"He C, Qu X, Cui L, Wang J, Kang JX (2009) Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A 106:11370\u201311375. \nhttps:\/\/doi.org\/10.1073\/pnas.0904835106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1139_CR44","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1553558","volume":"255","author":"BA Reynolds","year":"1992","unstructured":"Reynolds BA, Weiss S (1992) Nervous system generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707\u20131710","journal-title":"Science"},{"issue":"2","key":"1139_CR45","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/stem.2246","volume":"34","author":"Nobuyuki Sakayori","year":"2015","unstructured":"Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H et al. (2016) Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites. Stem Cells 34:470\u2013482 . doi: \nhttps:\/\/doi.org\/10.1002\/stem.2246","journal-title":"STEM CELLS"},{"key":"1139_CR46","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.neuroscience.2009.02.057","volume":"160","author":"M Katakura","year":"2009","unstructured":"Katakura M, Hashimoto M, Shahdat HM, Gamoh S, Okui T, Matsuzaki K, Shido O (2009) Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. Neuroscience 160:651\u2013660. \nhttps:\/\/doi.org\/10.1016\/j.neuroscience.2009.02.057","journal-title":"Neuroscience"},{"key":"1139_CR47","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1093\/jn\/130.12.3028","volume":"130","author":"JH Song","year":"2000","unstructured":"Song JH, Fujimoto K, Miyazawa T (2000) Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. J Nutr 130:3028\u20133033","journal-title":"J Nutr"},{"key":"1139_CR48","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.1073\/pnas.0402531101","volume":"101","author":"PK Mukherjee","year":"2004","unstructured":"Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A 101:8491\u20138496. \nhttps:\/\/doi.org\/10.1073\/pnas.0402531101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1139_CR49","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3177\/jnsv.54.501","volume":"54","author":"S Hiratsuka","year":"2008","unstructured":"Hiratsuka S, Ishihara K, Kitagawa T, Wada S, Yokogoshi H (2008) Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice. J Nutr Sci Vitaminol (Tokyo) 54:501\u2013506. \nhttps:\/\/doi.org\/10.3177\/jnsv.54.501","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"1139_CR50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0021-9150(00)00523-2","volume":"155","author":"JH Song","year":"2001","unstructured":"Song JH, Miyazawa T (2001) Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. Atherosclerosis 155:9\u201318. \nhttps:\/\/doi.org\/10.1016\/S0021-9150(00)00523-2","journal-title":"Atherosclerosis"},{"key":"1139_CR51","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1172\/JCI25420","volume":"115","author":"WJ Lukiw","year":"2005","unstructured":"Lukiw WJ, Cui J-G, Marcheselli VL, Bodker M, Botkjaer A, Gotlinger K, Serhan CN, Bazan NG (2005) A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 115:2774\u20132783. \nhttps:\/\/doi.org\/10.1172\/JCI25420","journal-title":"J Clin Invest"},{"issue":"44","key":"1139_CR52","doi-asserted-by":"publisher","first-page":"43807","DOI":"10.1074\/jbc.M305841200","volume":"278","author":"Victor L. Marcheselli","year":"2003","unstructured":"Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K, Musto A, Hardy M, Gimenez JM, et al. (2003) Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 278:43807\u201343817 . doi: \nhttps:\/\/doi.org\/10.1074\/jbc.M305841200","journal-title":"Journal of Biological Chemistry"},{"key":"1139_CR53","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1471-4159.2011.07606.x","volume":"120","author":"G Begum","year":"2012","unstructured":"Begum G, Kintner D, Liu Y, Cramer SW, Sun D (2012) DHA inhibits ER ca 2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem 120:622\u2013630. \nhttps:\/\/doi.org\/10.1111\/j.1471-4159.2011.07606.x","journal-title":"J Neurochem"},{"key":"1139_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/490476","volume":"2013","author":"M Katakura","year":"2013","unstructured":"Katakura M, Hashimoto M, Okui T (2013) Omega-3 polyunsaturated fatty acids enhance neuronal differentiation in cultured rat neural stem cells. Stem Cells Int 2013:1\u20139. \nhttps:\/\/doi.org\/10.1155\/2013\/490476","journal-title":"Stem Cells Int"},{"key":"1139_CR55","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0896-6273(00)00086-6","volume":"28","author":"X Qian","year":"2000","unstructured":"Qian X, Shen Q, Goderie SK, He W, Capela A, Davis AA, Temple S (2000) Timing of CNS cell generation. Neuron 28:69\u201380. \nhttps:\/\/doi.org\/10.1016\/S0896-6273(00)00086-6","journal-title":"Neuron"},{"issue":"12","key":"1139_CR56","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1634\/stemcells.2008-0293","volume":"26","author":"Yohei Okada","year":"2008","unstructured":"Okada Y, Matsumoto A, Shimazaki T, Enoki R, Koizumi A, Ishii S, Itoyama Y, Sobue G, et al. (2008) Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem\/progenitor cells. Stem Cells 26:3086\u20133098 . doi: \nhttps:\/\/doi.org\/10.1634\/stemcells.2008-0293","journal-title":"STEM CELLS"},{"key":"1139_CR57","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0022-3476(05)81247-8","volume":"120","author":"M Martinez","year":"1992","unstructured":"Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120:129\u2013138. \nhttps:\/\/doi.org\/10.1016\/S0022-3476(05)81247-8","journal-title":"J Pediatr"},{"key":"1139_CR58","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0378-3782(80)90015-8","volume":"4","author":"MT Clandinin","year":"1980","unstructured":"Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW (1980) Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 4:121\u2013129. \nhttps:\/\/doi.org\/10.1016\/0378-3782(80)90015-8","journal-title":"Early Hum Dev"},{"key":"1139_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0163-7827(00)00017-5","volume":"40","author":"L Lauritzen","year":"2001","unstructured":"Lauritzen L, Hansen HS, J\u00f8rgensen MH, Michaelsen KF (2001) The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40:1\u201394. \nhttps:\/\/doi.org\/10.1016\/S0163-7827(00)00017-5","journal-title":"Prog Lipid Res"},{"key":"1139_CR60","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1634\/stemcells.2006-0726","volume":"25","author":"B Hattiangady","year":"2007","unstructured":"Hattiangady B, Shuai B, Cai J, Coksaygan T, Rao MS, Shetty AK (2007) Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus. Stem Cells 25:2104\u20132117. \nhttps:\/\/doi.org\/10.1634\/stemcells.2006-0726","journal-title":"Stem Cells"},{"key":"1139_CR61","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.conb.2005.08.003","volume":"15","author":"DK Ma","year":"2005","unstructured":"Ma DK, Ming GL, Song H (2005) Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Curr Opin Neurobiol 15:514\u2013520. \nhttps:\/\/doi.org\/10.1016\/j.conb.2005.08.003","journal-title":"Curr Opin Neurobiol"},{"issue":"6","key":"1139_CR62","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/ana.410430608","volume":"43","author":"Tiina Sairanen","year":"1998","unstructured":"Sairanen T, Ristimaki A, Paetau A, Kaste M, Lindsberg PJ, Karjalainen-lindsberg M (1998) Cyclooxygenase-2 is induced globally in infarcted human Brian. Ann Neurol 738\u2013747","journal-title":"Annals of Neurology"},{"key":"1139_CR63","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00401-002-0590-0","volume":"104","author":"H Tomimoto","year":"2002","unstructured":"Tomimoto H, Shibata M, Ihara M, Akiguchi I, Ohtani R, Budka H (2002) A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. Acta Neuropathol 104:601\u2013607. \nhttps:\/\/doi.org\/10.1007\/s00401-002-0590-0","journal-title":"Acta Neuropathol"},{"key":"1139_CR64","doi-asserted-by":"publisher","first-page":"H1249","DOI":"10.1152\/ajpheart.1995.268.3.H1249","volume":"268","author":"T Ohtsuki","year":"1995","unstructured":"Ohtsuki T, Matsumoto M, Hayashi Y, Yamamoto K, Kitagawa K, Ogawa S, Yamamoto S, Kamada T (1995) Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. Am J Physiol Heart Circ Physiol 268:H1249\u2013H1257","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1139_CR65","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1038\/sj.bjp.0704189","volume":"133","author":"P Ciceri","year":"2001","unstructured":"Ciceri P, Rabuffetti M, Monopoli A, Nicosia S (2001) Production of leukotrienes in a model of focal cerebral ischaemia in the rat. Br J Pharmacol 133:1323\u20131329. \nhttps:\/\/doi.org\/10.1038\/sj.bjp.0704189","journal-title":"Br J Pharmacol"},{"issue":"2","key":"1139_CR66","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/01.STR.18.2.490","volume":"18","author":"M Usui","year":"1987","unstructured":"Usui M, Asano T, Takakura K, Model O, Instruments M, Ka-Y (1987) Identification and quantitative analysis of hydroxy-eicosatetraenoic acids in rat brains exposed to regional ischemia. Stroke 18:490\u2013494","journal-title":"Stroke"},{"key":"1139_CR67","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1194\/jlr.M053058","volume":"56","author":"L Sun","year":"2015","unstructured":"Sun L, Xu Y-W, Han J, Liang H, Wang N, Cheng Y (2015) 12\/15-lipoxygenase metabolites of arachidonic acid activate PPAR\u03b3: A possible neuroprotective effect in ischemic brain. J Lipid Res 56:502\u2013514. \nhttps:\/\/doi.org\/10.1194\/jlr.M053058","journal-title":"J Lipid Res"},{"key":"1139_CR68","doi-asserted-by":"publisher","first-page":"4754","DOI":"10.1007\/s12035-015-9355-3","volume":"53","author":"T Yagami","year":"2016","unstructured":"Yagami T, Koma H, Yamamoto Y (2016) Pathophysiological roles of cyclooxygenases and prostaglandins in the central nervous system. Mol Neurobiol 53:4754\u20134771. \nhttps:\/\/doi.org\/10.1007\/s12035-015-9355-3","journal-title":"Mol Neurobiol"},{"key":"1139_CR69","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijcard.2015.01.043","volume":"183","author":"H-J Lin","year":"2015","unstructured":"Lin H-J, Chen S-T, Wu H-Y, Hsu H-C, Chen M-F, Lee Y-T, Wu K-Y, Chien K-L (2015) Urinary biomarkers of oxidative and nitrosative stress and the risk for incident stroke: a nested case-control study from a community-based cohort. Int J Cardiol 183:214\u2013220. \nhttps:\/\/doi.org\/10.1016\/j.ijcard.2015.01.043","journal-title":"Int J Cardiol"},{"issue":"5","key":"1139_CR70","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1046\/j.1471-4159.2000.0752178.x","volume":"75","author":"Vladimir A. Tyurin","year":"2002","unstructured":"Tyurin VA, Tyurina YY, Borisenko GG, Sokolova T V, Ritov VB, Quinn PJ, Rose M, Kochanek P, et al. (2000) Oxidative stress following traumatic brain injury in rats: quantitation of biomarkers and detection of free radical intermediates. J Neurochem 75:2178\u20132189 . doi: \nhttps:\/\/doi.org\/10.1046\/j.1471-4159.2000.0752178.x","journal-title":"Journal of Neurochemistry"},{"issue":"3","key":"1139_CR71","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1161\/01.STR.0000055763.76479.E6","volume":"34","author":"Sonia Brault","year":"2003","unstructured":"Brault S, Martinez-Bermudez AK, Marrache AM, Gobeil F, Hou X, Beauchamp M, Quiniou C, Almazan G, et al. (2003) Selective neuromicrovascular endothelial cell death by 8-iso-prostaglandin f2: possible role in ischemic brain injury. Stroke 34:776\u2013782 . doi: \nhttps:\/\/doi.org\/10.1161\/01.STR.0000055763.76479.E6","journal-title":"Stroke"},{"key":"1139_CR72","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neures.2010.11.010","volume":"69","author":"J Yokose","year":"2011","unstructured":"Yokose J, Ishizuka T, Yoshida T, Aoki J, Koyanagi Y, Yawo H (2011) Lineage analysis of newly generated neurons in organotypic culture of rat hippocampus. Neurosci Res 69:223\u2013233. \nhttps:\/\/doi.org\/10.1016\/j.neures.2010.11.010","journal-title":"Neurosci Res"},{"key":"1139_CR73","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/cne.10675","volume":"460","author":"AG Dayer","year":"2003","unstructured":"Dayer AG, Ford AA, Cleaver KM, Yassaee M, Cameron HA (2003) Short-term and long-term survival of new neurons in the rat dentate gyrus. J Comp Neurol 460:563\u2013572. \nhttps:\/\/doi.org\/10.1002\/cne.10675","journal-title":"J Comp Neurol"},{"issue":"6","key":"1139_CR74","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/jnr.21036","volume":"84","author":"Tsutomu Sasaki","year":"2006","unstructured":"Sasaki T, Kitagawa K, Yagita Y, Sugiura S, Omura-Matsuoka E, Tanaka S, Matsushita K, Okano H, et al. (2006) Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus. J Neurosci Res 84:1187\u20131196 . doi: \nhttps:\/\/doi.org\/10.1002\/jnr.21036","journal-title":"Journal of Neuroscience Research"},{"issue":"9","key":"1139_CR75","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jnutbio.2008.06.014","volume":"20","author":"Hung-Chuan Pan","year":"2009","unstructured":"Pan HC, Kao TK, Ou YC, Yang DY, Yen YJ, Wang CC, Chuang YH, Liao SL, et al. (2009) Protective effect of docosahexaenoic acid against brain injury in ischemic rats. J Nutr Biochem 20:715\u2013725 . doi: \nhttps:\/\/doi.org\/10.1016\/j.jnutbio.2008.06.014","journal-title":"The Journal of Nutritional Biochemistry"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1139-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1139-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1139-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T05:25:14Z","timestamp":1579843514000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1139-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1139"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1139-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,1]]},"assertion":[{"value":"14 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}