{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T20:18:54Z","timestamp":1783801134298,"version":"3.55.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Universal-CNPq","award":["409859\/2016-8"],"award-info":[{"award-number":["409859\/2016-8"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s12035-018-1211-9","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T13:05:27Z","timestamp":1532610327000},"page":"2606-2617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by \u03b2-Amyloid Oligomers Administered to Mice"],"prefix":"10.1007","volume":"56","author":[{"given":"Michelle Lima","family":"Garcez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielle","family":"Mina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiani","family":"Bellettini-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Pereira","family":"da Luz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Luis","family":"Schiavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Matias Carollo","family":"Macieski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda Behenck","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariandne Oliveira","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Quadros","family":"Magnus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-2743","authenticated-orcid":false,"given":"Josiane","family":"Budni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"issue":"2","key":"1211_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ncl.2017.01.006","volume":"35","author":"AL Pierce","year":"2017","unstructured":"Pierce AL, Bullain SS, Kawas CH (2017) Late-Onset Alzheimer Disease. Neurol Clin 35(2):283\u2013293. https:\/\/doi.org\/10.1016\/j.ncl.2017.01.006","journal-title":"Neurol Clin"},{"issue":"3","key":"1211_CR2","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2174\/1567205013666151218150322","volume":"13","author":"JC Vickers","year":"2016","unstructured":"Vickers JC, Mitew S, Woodhouse A, Fernandez-Martos CM, Kirkcaldie MT, Canty AJ, McCormack GH, King AE (2016) Defining the earliest pathological changes of Alzheimer\u2019s disease. Curr Alzheimer Res 13(3):281\u2013287","journal-title":"Curr Alzheimer Res"},{"issue":"12","key":"1211_CR3","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/ng.2802","volume":"45","author":"Jean-Charles Lambert","year":"2013","unstructured":"Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC et al (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat Genet 45(12):1452\u20131458. https:\/\/doi.org\/10.1038\/ng.2802","journal-title":"Nature Genetics"},{"issue":"6","key":"1211_CR4","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nrn3880","volume":"16","author":"FL Heppner","year":"2015","unstructured":"Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 16(6):358\u2013372. https:\/\/doi.org\/10.1038\/nrn3880","journal-title":"Nat Rev Neurosci"},{"issue":"25","key":"1211_CR5","doi-asserted-by":"publisher","first-page":"22122","DOI":"10.1074\/jbc.M111.236257","volume":"286","author":"CA Lasagna-Reeves","year":"2011","unstructured":"Lasagna-Reeves CA, Glabe CG, Kayed R (2011) Amyloid-\u03b2 annular protofibrils evade fibrillar fate in Alzheimer disease brain. J Biol Chem 286(25):22122\u201322130. https:\/\/doi.org\/10.1074\/jbc.M111.236257","journal-title":"J Biol Chem"},{"issue":"5","key":"1211_CR6","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.neurobiolaging.2012.10.028","volume":"34","author":"GG Borlikova","year":"2013","unstructured":"Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E et al (2013) Alzheimer brain-derived amyloid beta-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging 34(5):1315\u20131327. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2012.10.028","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1211_CR7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1523\/JNEUROSCI.1698-16.2016","volume":"37","author":"Ting Yang","year":"2017","unstructured":"Yang T, Li S, Xu H (2017) Large soluble oligomers of amyloid beta-protein from Alzheimer brain are far less neuroactive than the smaller oligomers to which they dissociate. 37 (1):152\u2013163. doi: https:\/\/doi.org\/10.1523\/jneurosci.1698-16.2017","journal-title":"The Journal of Neuroscience"},{"issue":"1, Supplement","key":"1211_CR8","doi-asserted-by":"publisher","first-page":"S76","DOI":"10.1016\/j.jalz.2013.12.010","volume":"10","author":"ST Ferreira","year":"2014","unstructured":"Ferreira ST, Clarke JR, Bomfim TR, De Felice FG (2014) Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer\u2019s disease. Alzheimers Dement 10(1, Supplement):S76\u2013S83. https:\/\/doi.org\/10.1016\/j.jalz.2013.12.010","journal-title":"Alzheimers Dement"},{"issue":"1\u20132","key":"1211_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cca.2005.06.015","volume":"364","author":"V Solfrizzi","year":"2006","unstructured":"Solfrizzi V, D'Introno A, Colacicco AM, Capurso C, Todarello O, Pellicani V, Capurso SA, Pietrarossa G et al (2006) Circulating biomarkers of cognitive decline and dementia. Clin Chim Acta 364(1\u20132):91\u2013112. https:\/\/doi.org\/10.1016\/j.cca.2005.06.015","journal-title":"Clin Chim Acta"},{"issue":"4","key":"1211_CR10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/rej.2011.1302","volume":"15","author":"LW Harries","year":"2012","unstructured":"Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM et al (2012) Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res 15(4):395\u2013404. https:\/\/doi.org\/10.1089\/rej.2011.1302","journal-title":"Rejuvenation Res"},{"issue":"1","key":"1211_CR11","doi-asserted-by":"publisher","first-page":"e30525","DOI":"10.1371\/journal.pone.0030525","volume":"7","author":"K Westin","year":"2012","unstructured":"Westin K, Buchhave P, Nielsen H, Minthon L, Janciauskiene S, Hansson O (2012) CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer\u2019s disease. PLoS One 7(1):e30525. https:\/\/doi.org\/10.1371\/journal.pone.0030525","journal-title":"PLoS One"},{"key":"1211_CR12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","volume":"32","author":"D Nayak","year":"2014","unstructured":"Nayak D, Roth TL, McGavern DB (2014) Microglia development and function. Annu Rev Immunol 32:367\u2013402. https:\/\/doi.org\/10.1146\/annurev-immunol-032713-120240","journal-title":"Annu Rev Immunol"},{"key":"1211_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.expneurol.2014.01.001","volume":"258","author":"KA Kigerl","year":"2014","unstructured":"Kigerl KA, de Rivero Vaccari JP, Dietrich WD, Popovich PG, Keane RW (2014) Pattern recognition receptors and central nervous system repair. Exp Neurol 258:5\u201316. https:\/\/doi.org\/10.1016\/j.expneurol.2014.01.001","journal-title":"Exp Neurol"},{"issue":"3","key":"1211_CR14","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.intimp.2013.09.016","volume":"17","author":"W Lin","year":"2013","unstructured":"Lin W, Ding M, Xue J, Leng W (2013) The role of TLR2\/JNK\/NF-kappaB pathway in amyloid beta peptide-induced inflammatory response in mouse NG108-15 neural cells. Int Immunopharmacol 17(3):880\u2013884. https:\/\/doi.org\/10.1016\/j.intimp.2013.09.016","journal-title":"Int Immunopharmacol"},{"key":"1211_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fimmu.2017.00187","volume":"8","author":"JM Zolezzi","year":"2017","unstructured":"Zolezzi JM, Inestrosa NC (2017) Wnt\/TLR dialog in neuroinflammation, relevance in Alzheimer\u2019s disease. Front Immunol 8:187. https:\/\/doi.org\/10.3389\/fimmu.2017.00187","journal-title":"Front Immunol"},{"issue":"2","key":"1211_CR16","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1471-4159.2007.05001.x","volume":"104","author":"ML Udan","year":"2008","unstructured":"Udan ML, Ajit D, Crouse NR, Nichols MR (2008) Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line. J Neurochem 104(2):524\u2013533. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.05001.x","journal-title":"J Neurochem"},{"issue":"3","key":"1211_CR17","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.4049\/jimmunol.1101121","volume":"188","author":"S Liu","year":"2012","unstructured":"Liu S, Liu Y, Hao W, Wolf L, Kiliaan AJ, Penke B, Rube CE, Walter J et al (2012) TLR2 is a primary receptor for Alzheimer\u2019s amyloid beta peptide to trigger neuroinflammatory activation. J Immunol 188(3):1098\u20131107. https:\/\/doi.org\/10.4049\/jimmunol.1101121","journal-title":"J Immunol"},{"issue":"7434","key":"1211_CR18","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D et al (2013) NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature 493(7434):674\u2013678. https:\/\/doi.org\/10.1038\/nature11729","journal-title":"Nature"},{"key":"1211_CR19","doi-asserted-by":"publisher","first-page":"e975","DOI":"10.1038\/cddis.2013.503","volume":"4","author":"B Parajuli","year":"2013","unstructured":"Parajuli B, Sonobe Y, Horiuchi H, Takeuchi H, Mizuno T, Suzumura A (2013) Oligomeric amyloid beta induces IL-1beta processing via production of ROS: implication in Alzheimer\u2019s disease. Cell Death Dis 4:e975. https:\/\/doi.org\/10.1038\/cddis.2013.503","journal-title":"Cell Death Dis"},{"issue":"7","key":"1211_CR20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nri3705","volume":"14","author":"MT Heneka","year":"2014","unstructured":"Heneka MT, Kummer MP, Latz E (2014) Innate immune activation in neurodegenerative disease. Nat Rev Immunol 14(7):463\u2013477. https:\/\/doi.org\/10.1038\/nri3705","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"1211_CR21","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s12035-013-8475-x","volume":"48","author":"MS Tan","year":"2013","unstructured":"Tan MS, Yu JT, Jiang T, Zhu XC, Tan L (2013) The NLRP3 inflammasome in Alzheimer\u2019s disease. Mol Neurobiol 48(3):875\u2013882. https:\/\/doi.org\/10.1007\/s12035-013-8475-x","journal-title":"Mol Neurobiol"},{"key":"1211_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12504","volume":"7","author":"MJD Daniels","year":"2016","unstructured":"Daniels MJD, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS et al (2016) Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer\u2019s disease in rodent models. Nat Commun 7:12504. https:\/\/doi.org\/10.1038\/ncomms12504","journal-title":"Nat Commun"},{"key":"1211_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fncel.2017.00063","volume":"11","author":"L Song","year":"2017","unstructured":"Song L, Pei L, Yao S, Wu Y, Shang Y (2017) NLRP3 inflammasome in neurological diseases, from functions to therapies. Front Cell Neurosci 11:63. https:\/\/doi.org\/10.3389\/fncel.2017.00063","journal-title":"Front Cell Neurosci"},{"issue":"7","key":"1211_CR24","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/77528","volume":"6","author":"M Chen","year":"2000","unstructured":"Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L et al (2000) Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 6(7):797\u2013801. https:\/\/doi.org\/10.1038\/77528","journal-title":"Nat Med"},{"issue":"11","key":"1211_CR25","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1038\/sj.npp.1301377","volume":"32","author":"Y Choi","year":"2007","unstructured":"Choi Y, Kim HS, Shin KY, Kim EM, Kim M, Kim HS, Park CH, Jeong YH et al (2007) Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer\u2019s disease models. Neuropsychopharmacology 32(11):2393\u20132404. https:\/\/doi.org\/10.1038\/sj.npp.1301377","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"1211_CR26","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1096\/fj.08-113795","volume":"23","author":"W Noble","year":"2009","unstructured":"Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH (2009) Minocycline reduces the development of abnormal tau species in models of Alzheimer\u2019s disease. FASEB J 23(3):739\u2013750. https:\/\/doi.org\/10.1096\/fj.08-113795","journal-title":"FASEB J"},{"issue":"2","key":"1211_CR27","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3233\/jad-2010-100204","volume":"21","author":"A Parachikova","year":"2010","unstructured":"Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN (2010) Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimer\u2019s Dis 21(2):527\u2013542. https:\/\/doi.org\/10.3233\/jad-2010-100204","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"3","key":"1211_CR28","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.neuroscience.2008.06.036","volume":"155","author":"R Resende","year":"2008","unstructured":"Resende R, Ferreiro E, Pereira C, Resende de Oliveira C (2008) Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death. Neuroscience 155(3):725\u2013737. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.06.036","journal-title":"Neuroscience"},{"issue":"6","key":"1211_CR29","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.neuro.2011.05.014","volume":"32","author":"AM Ruiz-Mu\u00f1oz","year":"2011","unstructured":"Ruiz-Mu\u00f1oz AM, Nieto-Escamez FA, Aznar S, Colomina MT, Sanchez-Santed F (2011) Cognitive and histological disturbances after chlorpyrifos exposure and chronic A\u03b2(1\u201342) infusions in Wistar rats. NeuroToxicology 32(6):836\u2013844. https:\/\/doi.org\/10.1016\/j.neuro.2011.05.014","journal-title":"NeuroToxicology"},{"key":"1211_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.toxicon.2013.08.059","volume":"76","author":"GM Gomes","year":"2013","unstructured":"Gomes GM, Dalmolin GD, Cordeiro MN, Gomez MV, Ferreira J, Rubin MA (2013) The selective A-type K+ current blocker Tx3-1 isolated from the Phoneutria nigriventer venom enhances memory of na\u00efve and A\u03b225-35-treated mice. Toxicon 76:23\u201327. https:\/\/doi.org\/10.1016\/j.toxicon.2013.08.059","journal-title":"Toxicon"},{"issue":"4","key":"1211_CR31","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0160-5402(86)90038-0","volume":"16","author":"SE Laursen","year":"1986","unstructured":"Laursen SE, Belknap JK (1986) Intracerebroventricular injections in mice. Some methodological refinements. J Pharmacol Methods 16(4):355\u2013357","journal-title":"J Pharmacol Methods"},{"key":"1211_CR32","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1742-2094-9-62","volume":"9","author":"MT Ferretti","year":"2012","unstructured":"Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC (2012) Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer\u2019s disease-like amyloid pathology. J Neuroinflammation 9:62. https:\/\/doi.org\/10.1186\/1742-2094-9-62","journal-title":"J Neuroinflammation"},{"key":"1211_CR33","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/fpsyt.2010.00136","volume":"1","author":"CJ Garwood","year":"2010","unstructured":"Garwood CJ, Cooper JD, Hanger DP, Noble W (2010) Anti-inflammatory impact of minocycline in a mouse model of tauopathy. Front Psychiatry 1:136. https:\/\/doi.org\/10.3389\/fpsyt.2010.00136","journal-title":"Front Psychiatry"},{"issue":"3","key":"1211_CR34","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00213-012-2722-0","volume":"223","author":"M Salehi-Sadaghiani","year":"2012","unstructured":"Salehi-Sadaghiani M, Javadi-Paydar M, Gharedaghi MH, Zandieh A, Heydarpour P, Yousefzadeh-Fard Y, Dehpour AR (2012) NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice. Psychopharmacology 223(3):345\u2013355. https:\/\/doi.org\/10.1007\/s00213-012-2722-0","journal-title":"Psychopharmacology"},{"issue":"2","key":"1211_CR35","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1006\/nlme.1997.3746","volume":"67","author":"F Dellu","year":"1997","unstructured":"Dellu F, Fauchey V, Le Moal M, Simon H (1997) Extension of a new two-trial memory task in the rat: influence of environmental context on recognition processes. Neurobiol Learn Mem 67(2):112\u2013120","journal-title":"Neurobiol Learn Mem"},{"issue":"2","key":"1211_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0169-328X(99)00193-X","volume":"71","author":"R Roesler","year":"1999","unstructured":"Roesler R, Walz R, Quevedo J, de-Paris F, Zanata SM, Graner E, Izquierdo I, Martins VR et al (1999) Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C). Brain Res Mol Brain Res 71(2):349\u2013353","journal-title":"Brain Res Mol Brain Res"},{"issue":"1","key":"1211_CR37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"key":"1211_CR38","unstructured":"Allen Institute. Allen Mouse Brain Atlas (updated 23\/04\/2016). http:\/\/mouse.brain-map.org\/static\/atlas"},{"key":"1211_CR39","volume-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2004","unstructured":"Paxinos G, Franklin KBJ (2004) The mouse brain in stereotaxic coordinates. Academic Press, San Diego"},{"issue":"1","key":"1211_CR40","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jchemneu.2011.10.001","volume":"43","author":"DK Dhull","year":"2012","unstructured":"Dhull DK, Bhateja D, Dhull RK, Padi SS (2012) Differential role of cyclooxygenase isozymes on neuronal density in hippocampus CA1 region of intracerebroventricular streptozotocin treated rat brain. J Chem Neuroanat 43(1):48\u201351. https:\/\/doi.org\/10.1016\/j.jchemneu.2011.10.001","journal-title":"J Chem Neuroanat"},{"issue":"1","key":"1211_CR41","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/jrr\/rrw065","volume":"58","author":"N Mukumoto","year":"2017","unstructured":"Mukumoto N, Nakayama M, Akasaka H, Shimizu Y, Osuga S, Miyawaki D, Yoshida K, Ejima Y et al (2017) Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy. J Radiat Res 58(1):17\u201323. https:\/\/doi.org\/10.1093\/jrr\/rrw065","journal-title":"J Radiat Res"},{"key":"1211_CR42","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cortex.2015.03.016","volume":"67","author":"S Tu","year":"2015","unstructured":"Tu S, Wong S, Hodges JR, Irish M, Piguet O, Hornberger M (2015) Lost in spatial translation\u2014a novel tool to objectively assess spatial disorientation in Alzheimer\u2019s disease and frontotemporal dementia. Cortex 67:83\u201394. https:\/\/doi.org\/10.1016\/j.cortex.2015.03.016","journal-title":"Cortex"},{"key":"1211_CR43","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cortex.2016.07.003","volume":"83","author":"D Foxe","year":"2016","unstructured":"Foxe D, Leyton CE, Hodges JR, Burrell JR, Irish M, Piguet O (2016) The neural correlates of auditory and visuospatial span in logopenic progressive aphasia and Alzheimer\u2019s disease. Cortex 83:39\u201350. https:\/\/doi.org\/10.1016\/j.cortex.2016.07.003","journal-title":"Cortex"},{"key":"1211_CR44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pnpbp.2017.03.010","volume":"77","author":"ML Garcez","year":"2017","unstructured":"Garcez ML, Mina F, Bellettini-Santos T, Carneiro FG, Luz AP, Schiavo GL, Andrighetti MS, Scheid MG et al (2017) Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid beta (1-42) in mice. Prog Neuro-Psychopharmacol Biol Psychiatry 77:23\u201331. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.03.010","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"8","key":"1211_CR45","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1097\/NEN.0b013e3181aed9e6","volume":"68","author":"MA Bruno","year":"2009","unstructured":"Bruno MA, Leon WC, Fragoso G, Mushynski WE, Almazan G, Cuello AC (2009) Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease. J Neuropathol Exp Neurol 68(8):857\u2013869. https:\/\/doi.org\/10.1097\/NEN.0b013e3181aed9e6","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"1211_CR46","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000330363","volume":"9","author":"B Biscaro","year":"2012","unstructured":"Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM (2012) Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer\u2019s disease. Neurodegener Dis 9(4):187\u2013198. https:\/\/doi.org\/10.1159\/000330363","journal-title":"Neurodegener Dis"},{"issue":"7","key":"1211_CR47","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/glia.20338","volume":"53","author":"TJ Seabrook","year":"2006","unstructured":"Seabrook TJ, Jiang L, Maier M, Lemere CA (2006) Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia 53(7):776\u2013782. https:\/\/doi.org\/10.1002\/glia.20338","journal-title":"Glia"},{"issue":"6","key":"1211_CR48","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","volume":"160","author":"Y Wang","year":"2015","unstructured":"Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gifillian S, Krishnan GM et al (2015) TREM2 lipid sensing sustains microglia response in an Alzheimer\u2019s disease model. Cell 160(6):1061\u20131071. https:\/\/doi.org\/10.1016\/j.cell.2015.01.049","journal-title":"Cell"},{"issue":"4","key":"1211_CR49","doi-asserted-by":"publisher","first-page":"e1006315","DOI":"10.1371\/journal.ppat.1006315","volume":"13","author":"Sarah A. Tursi","year":"2017","unstructured":"Tursi SA, Lee EY (2017) Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9. 13(4):e1006315. doi: https:\/\/doi.org\/10.1371\/journal.ppat.1006315","journal-title":"PLOS Pathogens"},{"key":"1211_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1742-2094-5-15","volume":"5","author":"CJ Henry","year":"2008","unstructured":"Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, Sheridan JF, Godbout JP (2008) Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation 5:15\u201315. https:\/\/doi.org\/10.1186\/1742-2094-5-15","journal-title":"J Neuroinflammation"},{"key":"1211_CR51","doi-asserted-by":"publisher","first-page":"34228","DOI":"10.1038\/srep34228","volume":"6","author":"K Shahzad","year":"2016","unstructured":"Shahzad K, Bock F, Al-Dabet MM, Gadi I, Nazir S, Wang H, Kohli S, Ranjan S et al (2016) Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy. Sci Rep 6:34228. https:\/\/doi.org\/10.1038\/srep34228","journal-title":"Sci Rep"},{"issue":"4","key":"1211_CR52","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1007\/s12035-015-9318-8","volume":"53","author":"J Li","year":"2016","unstructured":"Li J, Chen J, Mo H, Chen J, Qian C, Yan F, Gu C, Hu Q et al (2016) Minocycline protects against NLRP3 inflammasome-induced inflammation and P53-associated apoptosis in early brain injury after subarachnoid hemorrhage. Mol Neurobiol 53(4):2668\u20132678. https:\/\/doi.org\/10.1007\/s12035-015-9318-8","journal-title":"Mol Neurobiol"},{"issue":"4","key":"1211_CR53","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1159\/000452172","volume":"23","author":"Y Lu","year":"2016","unstructured":"Lu Y, Xiao G, Luo W (2016) Minocycline suppresses NLRP3 inflammasome activation in experimental ischemic stroke. Neuroimmunomodulation 23(4):230\u2013238. https:\/\/doi.org\/10.1159\/000452172","journal-title":"Neuroimmunomodulation"},{"issue":"2","key":"1211_CR54","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00011-016-1002-6","volume":"66","author":"W Chen","year":"2017","unstructured":"Chen W, Zhao M, Zhao S, Lu Q, Ni L, Zou C, Lu L, Xu X et al (2017) Activation of the TXNIP\/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline. Inflamm Res 66(2):157\u2013166. https:\/\/doi.org\/10.1007\/s00011-016-1002-6","journal-title":"Inflamm Res"},{"key":"1211_CR55","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jns.2016.10.025","volume":"371","author":"Z Wu","year":"2016","unstructured":"Wu Z, Zou X, Zhu W, Mao Y, Chen L, Zhao F (2016) Minocycline is effective in intracerebral hemorrhage by inhibition of apoptosis and autophagy. J Neurol Sci 371:88\u201395. https:\/\/doi.org\/10.1016\/j.jns.2016.10.025","journal-title":"J Neurol Sci"},{"issue":"6884","key":"1211_CR56","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/417074a","volume":"417","author":"S Zhu","year":"2002","unstructured":"Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS et al (2002) Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417(6884):74\u201378. https:\/\/doi.org\/10.1038\/417074a","journal-title":"Nature"},{"issue":"18","key":"1211_CR57","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1093\/hmg\/ddr271","volume":"20","author":"M Sancho","year":"2011","unstructured":"Sancho M, Herrera AE, Gortat A, Carbajo RJ, Pineda-Lucena A, Orzaez M, Perez-Paya E (2011) Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1. Hum Mol Genet 20(18):3545\u20133553. https:\/\/doi.org\/10.1093\/hmg\/ddr271","journal-title":"Hum Mol Genet"},{"issue":"4","key":"1211_CR58","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.pharep.2017.02.001","volume":"69","author":"H Haghi-Aminjan","year":"2017","unstructured":"Haghi-Aminjan H, Asghari MH, Goharbari MH, Abdollahi M (2017) A systematic review on potential mechanisms of minocycline in kidney diseases. Pharmacol Rep 69(4):602\u2013609. https:\/\/doi.org\/10.1016\/j.pharep.2017.02.001","journal-title":"Pharmacol Rep"},{"issue":"7590","key":"1211_CR59","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"Y He","year":"2016","unstructured":"He Y, Zeng MY, Yang D, Motro B, Nunez G (2016) NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530(7590):354\u2013357. https:\/\/doi.org\/10.1038\/nature16959","journal-title":"Nature"},{"issue":"3","key":"1211_CR60","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nri.2016.151","volume":"17","author":"A Liston","year":"2017","unstructured":"Liston A, Masters SL (2017) Homeostasis-altering molecular processes as mechanisms of inflammasome activation. Nat Rev Immunol 17(3):208\u2013214. https:\/\/doi.org\/10.1038\/nri.2016.151","journal-title":"Nat Rev Immunol"},{"key":"1211_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2017.1293766","volume":"13","author":"D Wang","year":"2017","unstructured":"Wang D, Zhang J, Jiang W, Cao Z, Zhao F, Cai T, Aschner M, Luo W (2017) The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability. Autophagy 13:1\u201314. https:\/\/doi.org\/10.1080\/15548627.2017.1293766","journal-title":"Autophagy"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1211-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1211-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1211-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T06:21:39Z","timestamp":1661667699000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1211-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,26]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1211"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1211-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,26]]},"assertion":[{"value":"4 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}