{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:20:34Z","timestamp":1769264434716,"version":"3.49.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["CNPq Edital Universal 2016"],"award-info":[{"award-number":["CNPq Edital Universal 2016"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s12035-018-1222-6","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T15:35:57Z","timestamp":1531323357000},"page":"2174-2184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of the Nrf2\/HO-1 Axis Suppresses the Mitochondria-Related Protection Promoted by Gastrodin in Human Neuroblastoma Cells Exposed to Paraquat"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-6605","authenticated-orcid":false,"given":"Marcos Roberto","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via","family":"de Bittencourt Brasil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Ribas","family":"F\u00fcrstenau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"1222_CR1","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neuron.2012.08.019","volume":"75","author":"JJ Harris","year":"2012","unstructured":"Harris JJ, Jolivet R, Attwell D (2012) Synaptic energy use and supply. Neuron 75:762\u2013777. https:\/\/doi.org\/10.1016\/j.neuron.2012.08.019","journal-title":"Neuron"},{"key":"1222_CR2","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","volume":"86","author":"PJ Magistretti","year":"2015","unstructured":"Magistretti PJ, Allaman I (2015) A cellular perspective on brain energy metabolism and functional imaging. Neuron 86:883\u2013901. https:\/\/doi.org\/10.1016\/j.neuron.2015.03.035","journal-title":"Neuron"},{"key":"1222_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj2840001","volume":"284","author":"GC Brown","year":"1992","unstructured":"Brown GC (1992) Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J 284:1\u201313","journal-title":"Biochem J"},{"key":"1222_CR4","doi-asserted-by":"publisher","first-page":"e690","DOI":"10.1371\/journal.pone.0000690","volume":"2","author":"RJ Mailloux","year":"2007","unstructured":"Mailloux RJ, B\u00e9riault R, Lemire J, Singh R, Ch\u00e9nier DR, Hamel RD, Appanna VD (2007) The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS One 2:e690","journal-title":"PLoS One"},{"key":"1222_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-94-007-2869-1_1","volume":"942","author":"S Papa","year":"2012","unstructured":"Papa S, Martino PL, Capitanio G, Gaballo A, De Rasmo D, Signorile A, Petruzzella V (2012) The oxidative phosphorylation system in mammalian mitochondria. Adv Exp Med Biol 942:3\u201337. https:\/\/doi.org\/10.1007\/978-94-007-2869-1_1","journal-title":"Adv Exp Med Biol"},{"key":"1222_CR6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1023\/A:1022402915431","volume":"29","author":"F Capuano","year":"1997","unstructured":"Capuano F, Guerrieri F, Papa S (1997) Oxidative phosphorylation enzymes in normal and neoplastic cell growth. J Bioenerg Biomembr 29:379\u2013384","journal-title":"J Bioenerg Biomembr"},{"key":"1222_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/biof.5520250103","volume":"25","author":"ML Genova","year":"2005","unstructured":"Genova ML, Bianchi C, Lenaz G (2005) Supercomplex organization of the mitochondrial respiratory chain and the role of the Coenzyme Q pool: pathophysiological implications. Biofactors 25:5\u201320","journal-title":"Biofactors"},{"key":"1222_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s10540-007-9033-4","volume":"27","author":"G Solaini","year":"2007","unstructured":"Solaini G, Sgarbi G, Lenaz G, Baracca A (2007) Evaluating mitochondrial membrane potential in cells. Biosci Rep 27:11\u201321. https:\/\/doi.org\/10.1007\/s10540-007-9033-4","journal-title":"Biosci Rep"},{"key":"1222_CR9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0021-9258(19)57189-7","volume":"217","author":"B Chance","year":"1955","unstructured":"Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. I Kinetics of oxygen utilization. J Biol Chem 217:383\u2013393","journal-title":"J Biol Chem"},{"key":"1222_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1385\/MN:31:1-3:043","volume":"31","author":"GE Gibson","year":"2005","unstructured":"Gibson GE, Blass JP, Beal MF, Bunik V (2005) The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol Neurobiol 31:43\u201363","journal-title":"Mol Neurobiol"},{"key":"1222_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1385\/MN:31:1-3:081","volume":"31","author":"M Naoi","year":"2005","unstructured":"Naoi M, Maruyama W, Shamoto-Nagai M, Yi H, Akao Y, Tanaka M (2005) Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders. Mol Neurobiol 31:81\u201393","journal-title":"Mol Neurobiol"},{"key":"1222_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mam.2004.02.005","volume":"25","author":"E Cadenas","year":"2004","unstructured":"Cadenas E (2004) Mitochondrial free radical production and cell signaling. Mol Asp Med 25:17\u201326. https:\/\/doi.org\/10.1016\/j.mam.2004.02.005","journal-title":"Mol Asp Med"},{"key":"1222_CR13","doi-asserted-by":"publisher","first-page":"8735","DOI":"10.1074\/jbc.R113.544635","volume":"289","author":"H Sies","year":"2014","unstructured":"Sies H (2014) Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem 289:8735\u20138741. https:\/\/doi.org\/10.1074\/jbc.R113.544635","journal-title":"J Biol Chem"},{"key":"1222_CR14","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","volume":"86","author":"H Sies","year":"2017","unstructured":"Sies H, Berndt C, Jones DP (2017) Oxidative stress. Annu Rev Biochem 86:715\u2013748. https:\/\/doi.org\/10.1146\/annurev-biochem-061516-045037","journal-title":"Annu Rev Biochem"},{"key":"1222_CR15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.mito.2007.06.001","volume":"7","author":"H Atamna","year":"2007","unstructured":"Atamna H, Frey WH 2nd (2007) Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer\u2019s disease. Mitochondrion 7:297\u2013310. https:\/\/doi.org\/10.1016\/j.mito.2007.06.001","journal-title":"Mitochondrion"},{"key":"1222_CR16","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s12035-010-8113-9","volume":"41","author":"Z Gu","year":"2010","unstructured":"Gu Z, Nakamura T, Lipton SA (2010) Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol 41:55\u201372. https:\/\/doi.org\/10.1007\/s12035-010-8113-9","journal-title":"Mol Neurobiol"},{"key":"1222_CR17","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12035-012-8352-z","volume":"47","author":"W Ahmad","year":"2013","unstructured":"Ahmad W (2013) Overlapped metabolic and therapeutic links between Alzheimer and diabetes. Mol Neurobiol 47:399\u2013424. https:\/\/doi.org\/10.1007\/s12035-012-8352-z","journal-title":"Mol Neurobiol"},{"key":"1222_CR18","doi-asserted-by":"publisher","first-page":"140267","DOI":"10.1155\/2015\/140267","volume":"2015","author":"MR Oliveira de","year":"2015","unstructured":"de Oliveira MR (2015) Vitamin A and retinoids as mitochondrial toxicants. Oxidative Med Cell Longev 2015:140267\u2013140213. https:\/\/doi.org\/10.1155\/2015\/140267","journal-title":"Oxidative Med Cell Longev"},{"key":"1222_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.toxlet.2016.07.001","volume":"258","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR (2016) Fluoxetine and the mitochondria: a review of the toxicological aspects. Toxicol Lett 258:185\u2013191. https:\/\/doi.org\/10.1016\/j.toxlet.2016.07.001","journal-title":"Toxicol Lett"},{"key":"1222_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neuint.2015.12.006","volume":"92","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Jardim FR (2016) Cocaine and mitochondria-related signaling in the brain: a mechanistic view and future directions. Neurochem Int 92:58\u201366. https:\/\/doi.org\/10.1016\/j.neuint.2015.12.006","journal-title":"Neurochem Int"},{"key":"1222_CR21","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1007\/s12035-015-9515-5","volume":"53","author":"C Cadonic","year":"2016","unstructured":"Cadonic C, Sabbir MG, Albensi BC (2016) Mechanisms of mitochondrial dysfunction in Alzheimer\u2019s disease. Mol Neurobiol 53:6078\u20136090. https:\/\/doi.org\/10.1007\/s12035-015-9515-5","journal-title":"Mol Neurobiol"},{"key":"1222_CR22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.tox.2017.07.013","volume":"391","author":"C Blajszczak","year":"2017","unstructured":"Blajszczak C, Bonini MG (2017) Mitochondria targeting by environmental stressors: implications for redox cellular signaling. Toxicology 391:84\u201389. https:\/\/doi.org\/10.1016\/j.tox.2017.07.013","journal-title":"Toxicology"},{"key":"1222_CR23","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1007\/s12035-016-0140-8","volume":"54","author":"M Rodr\u00edguez-Arribas","year":"2017","unstructured":"Rodr\u00edguez-Arribas M, Yakhine-Diop SMS, Pedro JMB, G\u00f3mez-Suaga P, G\u00f3mez-S\u00e1nchez R, Mart\u00ednez-Chac\u00f3n G, Fuentes JM, Gonz\u00e1lez-Polo RA et al (2017) Mitochondria-associated membranes (MAMs): overview and its role in Parkinson\u2019s disease. Mol Neurobiol 54:6287\u20136303. https:\/\/doi.org\/10.1007\/s12035-016-0140-8","journal-title":"Mol Neurobiol"},{"key":"1222_CR24","doi-asserted-by":"publisher","first-page":"13291","DOI":"10.1074\/jbc.R900010200","volume":"284","author":"T Nguyen","year":"2009","unstructured":"Nguyen T, Nioi P, Pickett CB (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284:13291\u201313295. https:\/\/doi.org\/10.1074\/jbc.R900010200","journal-title":"J Biol Chem"},{"key":"1222_CR25","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.freeradbiomed.2004.04.033","volume":"37","author":"T Nguyen","year":"2004","unstructured":"Nguyen T, Yang CS, Pickett CB (2004) The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 37:433\u2013441","journal-title":"Free Radic Biol Med"},{"key":"1222_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev.pharmtox.43.100901.140229","volume":"43","author":"T Nguyen","year":"2003","unstructured":"Nguyen T, Sherratt PJ, Pickett CB (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43:233\u2013260","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1222_CR27","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.bbamcr.2008.05.024","volume":"1783","author":"W Li","year":"2008","unstructured":"Li W, Yu S, Liu T, Kim JH, Blank V, Li H, Kong AN (2008) Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif. Biochim Biophys Acta 1783:1847\u20131856. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.05.024","journal-title":"Biochim Biophys Acta"},{"key":"1222_CR28","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1021\/tx050217c","volume":"18","author":"AT Dinkova-Kostova","year":"2005","unstructured":"Dinkova-Kostova AT, Holtzclaw WD, Kensler TW (2005) The role of Keap1 in cellular protective responses. Chem Res Toxicol 18:1779\u20131791. https:\/\/doi.org\/10.1021\/tx050217c","journal-title":"Chem Res Toxicol"},{"key":"1222_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbagen.2005.10.010","volume":"1760","author":"D Toroser","year":"2006","unstructured":"Toroser D, Yarian CS, Orr WC, Sohal RS (2006) Mechanisms of gamma-glutamylcysteine ligase regulation. Biochim Biophys Acta 1760:233\u2013244. https:\/\/doi.org\/10.1016\/j.bbagen.2005.10.010","journal-title":"Biochim Biophys Acta"},{"key":"1222_CR30","doi-asserted-by":"publisher","first-page":"6102","DOI":"10.1046\/j.1432-1327.2000.01701.x","volume":"267","author":"ES Arn\u00e9r","year":"2000","unstructured":"Arn\u00e9r ES, Holmgren A (2000) Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem 267:6102\u20136109","journal-title":"Eur J Biochem"},{"key":"1222_CR31","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s12035-012-8282-9","volume":"46","author":"S Schaffer","year":"2012","unstructured":"Schaffer S, Asseburg H, Kuntz S, Muller WE, Eckert GP (2012) Effects of polyphenols on brain ageing and Alzheimer\u2019s disease: focus on mitochondria. Mol Neurobiol 46:161\u2013178. https:\/\/doi.org\/10.1007\/s12035-012-8282-9","journal-title":"Mol Neurobiol"},{"key":"1222_CR32","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1124\/pr.117.014753","volume":"70","author":"A Cuadrado","year":"2018","unstructured":"Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, Ghezzi P, Le\u00f3n R et al (2018) Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach. Pharmacol Rev 70:348\u2013383. https:\/\/doi.org\/10.1124\/pr.117.014753","journal-title":"Pharmacol Rev"},{"key":"1222_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.mam.2011.10.007","volume":"32","author":"V Calabrese","year":"2011","unstructured":"Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ (2011) Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Asp Med 32:279\u2013304. https:\/\/doi.org\/10.1016\/j.mam.2011.10.007","journal-title":"Mol Asp Med"},{"key":"1222_CR34","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3844\/ajptsp.2008.152.159","volume":"3","author":"JA Baur","year":"2008","unstructured":"Baur JA, Sinclair DA (2008) What is xenohormesis? Am J Pharmacol Toxicol 3:152\u2013159. https:\/\/doi.org\/10.3844\/ajptsp.2008.152.159","journal-title":"Am J Pharmacol Toxicol"},{"key":"1222_CR35","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/biof.22","volume":"35","author":"V Calabrese","year":"2009","unstructured":"Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ (2009) Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis. Biofactors 35:146\u2013160. https:\/\/doi.org\/10.1002\/biof.22","journal-title":"Biofactors"},{"key":"1222_CR36","doi-asserted-by":"publisher","first-page":"877","DOI":"10.2174\/138161210790883615","volume":"16","author":"V Calabrese","year":"2010","unstructured":"Calabrese V, Cornelius C, Trovato A, Cavallaro M, Mancuso C, Di Rienzo L, Condorelli D, De Lorenzo A et al (2010) The hormetic role of dietary antioxidants in free radical-related diseases. Curr Pharm Des 16:877\u2013883","journal-title":"Curr Pharm Des"},{"key":"1222_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/biof.1256","volume":"42","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR (2016) Phloretin-induced cytoprotective effects on mammalian cells: a mechanistic view and future directions. Biofactors 42:13\u201340. https:\/\/doi.org\/10.1002\/biof.1256","journal-title":"Biofactors"},{"key":"1222_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mito.2016.05.005","volume":"29","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR (2016) Evidence for genistein as a mitochondriotropic molecule. Mitochondrion 29:35\u201344. https:\/\/doi.org\/10.1016\/j.mito.2016.05.005","journal-title":"Mitochondrion"},{"key":"1222_CR39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.bbagen.2016.01.017","volume":"1860","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Nabavi SF, Manayi A, Daglia M, Hajheydari Z, Nabavi SM (2016) Resveratrol and the mitochondria: from triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view. Biochim Biophys Acta 1860:727\u2013745. https:\/\/doi.org\/10.1016\/j.bbagen.2016.01.017","journal-title":"Biochim Biophys Acta"},{"key":"1222_CR40","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.biotechadv.2015.12.014","volume":"34","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Nabavi SM, Braidy N, Setzer WN, Ahmed T, Nabavi SF (2016) Quercetin and the mitochondria: a mechanistic view. Biotechnol Adv 34:532\u2013549. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.12.014","journal-title":"Biotechnol Adv"},{"key":"1222_CR41","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.phrs.2015.08.021","volume":"100","author":"MR Oliveira de","year":"2015","unstructured":"de Oliveira MR, Nabavi SF, Habtemariam S, Erdogan Orhan I, Daglia M, Nabavi SM (2015) The effects of baicalein and baicalin on mitochondrial function and dynamics: a review. Pharmacol Res 100:296\u2013308. https:\/\/doi.org\/10.1016\/j.phrs.2015.08.021","journal-title":"Pharmacol Res"},{"key":"1222_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.phrs.2015.12.027","volume":"104","author":"MR Oliveira","year":"2016","unstructured":"Oliveira MR, Nabavi SF, Daglia M, Rastrelli L, Nabavi SM (2016) Epigallocatechin gallate and mitochondria\u2014a story of life and death. Pharmacol Res 104:70\u201385. https:\/\/doi.org\/10.1016\/j.phrs.2015.12.027","journal-title":"Pharmacol Res"},{"key":"1222_CR43","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1007\/s12035-017-0448-z","volume":"55","author":"FR Jardim","year":"2018","unstructured":"Jardim FR, de Rossi FT, Nascimento MX, da Silva Barros RG, Borges PA, Prescilio IC, de Oliveira MR (2018) Resveratrol and brain mitochondria: a review. Mol Neurobiol 55:2085\u20132101. https:\/\/doi.org\/10.1007\/s12035-017-0448-z","journal-title":"Mol Neurobiol"},{"key":"1222_CR44","doi-asserted-by":"publisher","unstructured":"de Oliveira MR (2018) Carnosic acid as a promising agent in protecting mitochondria of brain cells. Mol Neurobiol (IN PRESS) https:\/\/doi.org\/10.1007\/s12035-017-0842-6","DOI":"10.1007\/s12035-017-0842-6"},{"key":"1222_CR45","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s12035-016-0380-7","volume":"55","author":"MR Oliveira de","year":"2018","unstructured":"de Oliveira MR, da Costa Ferreira G, Brasil FB, Peres A (2018) Pinocembrin suppresses H2O2-induced mitochondrial dysfunction by a mechanism dependent on the Nrf2\/HO-1 axis in SH-SY5Y cells. Mol Neurobiol 55:989\u20131003. https:\/\/doi.org\/10.1007\/s12035-016-0380-7","journal-title":"Mol Neurobiol"},{"key":"1222_CR46","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1007\/s12035-016-9839-9","volume":"54","author":"T Ahmed","year":"2017","unstructured":"Ahmed T, Javed S, Javed S, Tariq A, \u0160amec D, Tejada S, Nabavi SF, Braidy N et al (2017) Resveratrol and Alzheimer\u2019s disease: mechanistic insights. Mol Neurobiol 54:2622\u20132635. https:\/\/doi.org\/10.1007\/s12035-016-9839-9","journal-title":"Mol Neurobiol"},{"key":"1222_CR47","doi-asserted-by":"publisher","first-page":"814058","DOI":"10.1155\/2013\/814058","volume":"2013","author":"HT Chung","year":"2013","unstructured":"Chung HT, Ryter SW, Kim HP (2013) Heme oxygenase-1 as a novel metabolic player. Oxidative Med Cell Longev 2013:814058\u2013814052. https:\/\/doi.org\/10.1155\/2013\/814058","journal-title":"Oxidative Med Cell Longev"},{"key":"1222_CR48","doi-asserted-by":"publisher","first-page":"69075","DOI":"10.18632\/oncotarget.11923","volume":"7","author":"L Vanella","year":"2016","unstructured":"Vanella L, Barbagallo I, Tibullo D, Forte S, Zappal\u00e0 A, Li Volti G (2016) The non-canonical functions of the heme oxygenases. Oncotarget 7:69075\u201369086. https:\/\/doi.org\/10.18632\/oncotarget.11923","journal-title":"Oncotarget"},{"key":"1222_CR49","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1089\/ars.2007.1807","volume":"9","author":"R Ollinger","year":"2007","unstructured":"Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH (2007) Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal 9:2175\u20132185","journal-title":"Antioxid Redox Signal"},{"key":"1222_CR50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3164\/jcbn.2008029","volume":"42","author":"HO Pae","year":"2008","unstructured":"Pae HO, Kim EC, Chung HT (2008) Integrative survival response evoked by heme oxygenase-1 and heme metabolites. J Clin Biochem Nutr 42:197\u2013203. https:\/\/doi.org\/10.3164\/jcbn.2008029","journal-title":"J Clin Biochem Nutr"},{"key":"1222_CR51","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.tem.2017.11.005","volume":"29","author":"L Rochette","year":"2018","unstructured":"Rochette L, Zeller M, Cottin Y, Vergely C (2018) Redox functions of heme oxygenase-1 and biliverdin reductase in diabetes. Trends Endocrinol Metab 29:74\u201385. https:\/\/doi.org\/10.1016\/j.tem.2017.11.005","journal-title":"Trends Endocrinol Metab"},{"key":"1222_CR52","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.molmed.2006.06.007","volume":"12","author":"FH Bach","year":"2006","unstructured":"Bach FH (2006) Carbon monoxide: from the origin of life to molecular medicine. Trends Mol Med 12:348\u2013350","journal-title":"Trends Mol Med"},{"key":"1222_CR53","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1:a001651. https:\/\/doi.org\/10.1101\/cshperspect.a001651","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1222_CR54","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1476-4598-12-86","volume":"12","author":"B Hoesel","year":"2013","unstructured":"Hoesel B, Schmid JA (2013) The complexity of NF-\u03baB signaling in inflammation and cancer. Mol Cancer 12:86. https:\/\/doi.org\/10.1186\/1476-4598-12-86","journal-title":"Mol Cancer"},{"key":"1222_CR55","doi-asserted-by":"publisher","first-page":"5961","DOI":"10.1007\/s12035-016-0100-3","volume":"54","author":"MR Oliveira de","year":"2017","unstructured":"de Oliveira MR, Peres A, Ferreira GC, Schuck PF, Gama CS, Bosco SMD (2017) Carnosic acid protects mitochondria of human neuroblastoma SH-SY5Y cells exposed to Paraquat through activation of the Nrf2\/HO-1Axis. Mol Neurobiol 54:5961\u20135972. https:\/\/doi.org\/10.1007\/s12035-016-0100-3","journal-title":"Mol Neurobiol"},{"key":"1222_CR56","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1080\/14786410601081997","volume":"21","author":"XD Yang","year":"2007","unstructured":"Yang XD, Zhu J, Yang R, Liu JP, Li L, Zhang HB (2007) Phenolic constituents from the rhizomes of Gastrodia elata. Nat Prod Res 21:180\u2013186. https:\/\/doi.org\/10.1080\/14786410601081997","journal-title":"Nat Prod Res"},{"key":"1222_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00024","volume":"9","author":"Y Liu","year":"2018","unstructured":"Liu Y, Gao J, Peng M, Meng H, Ma H, Cai P, Xu Y, Zhao Q et al (2018) A review on central nervous system effects of gastrodin. Front Pharmacol 9:24. https:\/\/doi.org\/10.3389\/fphar.2018.00024","journal-title":"Front Pharmacol"},{"key":"1222_CR58","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s12031-018-1027-0","volume":"64","author":"MR Oliveira de","year":"2018","unstructured":"de Oliveira MR, Brasil FB, F\u00fcrstenau CR (2018) Evaluation of the mitochondria-related redox and bioenergetics effects of gastrodin in SH-SY5Y cells exposed to hydrogen peroxide. J Mol Neurosci 64:242\u2013251. https:\/\/doi.org\/10.1007\/s12031-018-1027-0","journal-title":"J Mol Neurosci"},{"key":"1222_CR59","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3109\/10715762.2014.899694","volume":"48","author":"T Blanco-Ayala","year":"2014","unstructured":"Blanco-Ayala T, And\u00e9rica-Romero AC, Pedraza-Chaverri J (2014) New insights into antioxidant strategies against paraquat toxicity. Free Radic Res 48:623\u2013640. https:\/\/doi.org\/10.3109\/10715762.2014.899694","journal-title":"Free Radic Res"},{"key":"1222_CR60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0300-483X(02)00382-7","volume":"180","author":"ZE Suntres","year":"2002","unstructured":"Suntres ZE (2002) Role of antioxidants in paraquat toxicity. Toxicology 180:65\u201377","journal-title":"Toxicology"},{"key":"1222_CR61","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/jbt.20348","volume":"24","author":"JM Mor\u00e1n","year":"2010","unstructured":"Mor\u00e1n JM, Ortiz-Ortiz MA, Ruiz-Mesa LM, Fuentes JM (2010) Nitric oxide in paraquat-mediated toxicity: a review. J Biochem Mol Toxicol 24:402\u2013409. https:\/\/doi.org\/10.1002\/jbt.20348","journal-title":"J Biochem Mol Toxicol"},{"key":"1222_CR62","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.freeradbiomed.2015.08.021","volume":"89","author":"EL Robb","year":"2015","unstructured":"Robb EL, Gawel JM, Aksentijevi\u0107 D, Cochem\u00e9 HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA et al (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic Biol Med 89:883\u2013894. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.08.021","journal-title":"Free Radic Biol Med"},{"key":"1222_CR63","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.tiv.2015.12.005","volume":"32","author":"MR Oliveira de","year":"2016","unstructured":"de Oliveira MR, Ferreira GC, Schuck PF (2016) Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: role for PI3K\/Akt\/Nrf2 pathway. Toxicol in Vitro 32:41\u201354. https:\/\/doi.org\/10.1016\/j.tiv.2015.12.005","journal-title":"Toxicol in Vitro"},{"key":"1222_CR64","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.1007\/s12035-016-0009-x","volume":"54","author":"MR Oliveira de","year":"2017","unstructured":"de Oliveira MR, Schuck PF, Bosco SMD (2017) Tanshinone I induces mitochondrial protection through an Nrf2-dependent mechanism in Paraquat-treated human neuroblastoma SH-SY5Y cells. Mol Neurobiol 54:4597\u20134608. https:\/\/doi.org\/10.1007\/s12035-016-0009-x","journal-title":"Mol Neurobiol"},{"key":"1222_CR65","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363","journal-title":"J Immunol Methods"},{"key":"1222_CR66","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s11064-016-2140-5","volume":"42","author":"MR Oliveira de","year":"2017","unstructured":"de Oliveira MR, Peres A, Ferreira GC (2017) Pinocembrin attenuates mitochondrial dysfunction in human neuroblastoma SH-SY5Y cells exposed to methylglyoxal: role for the Erk1\/2-Nrf2 signaling pathway. Neurochem Res 42:1057\u20131072. https:\/\/doi.org\/10.1007\/s11064-016-2140-5","journal-title":"Neurochem Res"},{"key":"1222_CR67","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s11064-018-2495-x","volume":"43","author":"MR Oliveira de","year":"2018","unstructured":"de Oliveira MR, Andrade CMB, F\u00fcrstenau CR (2018) Naringenin exerts anti-inflammatory effects in Paraquat-treated SH-SY5Y cells through a mechanism associated with the Nrf2\/HO-1 axis. Neurochem Res 43:894\u2013903. https:\/\/doi.org\/10.1007\/s11064-018-2495-x","journal-title":"Neurochem Res"},{"key":"1222_CR68","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1007\/s12035-017-0389-6","volume":"55","author":"MR Oliveira de","year":"2018","unstructured":"de Oliveira MR, de Souza ICC, F\u00fcrstenau CR (2018) Carnosic acid induces anti-inflammatory effects in Paraquat-treated SH-SY5Y cells through a mechanism involving a crosstalk between the Nrf2\/HO-1 axis and NF-\u03baB. Mol Neurobiol 55:890\u2013897. https:\/\/doi.org\/10.1007\/s12035-017-0389-6","journal-title":"Mol Neurobiol"},{"key":"1222_CR69","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10571-013-0006-9","volume":"34","author":"K Wang","year":"2014","unstructured":"Wang K, Zhu L, Zhu X, Zhang K, Huang B, Zhang J, Zhang Y, Zhu L et al (2014) Protective effect of paeoniflorin on A\u03b225-35-induced SH-SY5Y cell injury by preventing mitochondrial dysfunction. Cell Mol Neurobiol 34:227\u2013234. https:\/\/doi.org\/10.1007\/s10571-013-0006-9","journal-title":"Cell Mol Neurobiol"},{"key":"1222_CR70","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/abbi.1996.0146","volume":"328","author":"JJ Poderoso","year":"1996","unstructured":"Poderoso JJ, Carreras MC, Lisdero C, Riob\u00f3 N, Sch\u00f6pfer F, Boveris A (1996) Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys 328:85\u201392","journal-title":"Arch Biochem Biophys"},{"key":"1222_CR71","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1021\/tx00026a012","volume":"5","author":"CP LeBel","year":"1992","unstructured":"LeBel CP, Ischiropoulos H, Bondy SC (1992) Evaluation of the probe 2\u2032,7\u2032-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227\u2013231","journal-title":"Chem Res Toxicol"},{"key":"1222_CR72","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1002\/jnr.22543","volume":"89","author":"A Quesada","year":"2011","unstructured":"Quesada A, Ogi J, Schultz J, Handforth A (2011) C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase C\u03f5\/Nrf2 pathway. J Neurosci Res 89:394\u2013405. https:\/\/doi.org\/10.1002\/jnr.22543","journal-title":"J Neurosci Res"},{"key":"1222_CR73","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s10571-014-0128-8","volume":"35","author":"X Jin","year":"2015","unstructured":"Jin X, Liu Q, Jia L, Li M, Wang X (2015) Pinocembrin attenuates 6-OHDA-induced neuronal cell death through Nrf2\/ARE pathway in SH-SY5Y cells. Cell Mol Neurobiol 35:323\u2013333. https:\/\/doi.org\/10.1007\/s10571-014-0128-8","journal-title":"Cell Mol Neurobiol"},{"key":"1222_CR74","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuint.2014.06.003","volume":"75","author":"G Jiang","year":"2014","unstructured":"Jiang G, Hu Y, Liu L, Cai J, Peng C, Li Q (2014) Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK\/Nrf2 pathway in human dopaminergic cells. Neurochem Int 75:79\u201388. https:\/\/doi.org\/10.1016\/j.neuint.2014.06.003","journal-title":"Neurochem Int"},{"key":"1222_CR75","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.lfs.2014.08.004","volume":"114","author":"XL Wang","year":"2014","unstructured":"Wang XL, Xing GH, Hong B, Li XM, Zou Y, Zhang XJ, Dong MX (2014) Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: involvement of ERK1\/2-Nrf2 signaling pathway. Life Sci 114:77\u201385. https:\/\/doi.org\/10.1016\/j.lfs.2014.08.004","journal-title":"Life Sci"},{"key":"1222_CR76","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s11064-015-1513-5","volume":"40","author":"Z Peng","year":"2015","unstructured":"Peng Z, Wang S, Chen G, Cai M, Liu R, Deng J, Liu J, Zhang T et al (2015) Gastrodin alleviates cerebral ischemic damage in mice by improving anti-oxidant and anti-inflammation activities and inhibiting apoptosis pathway. Neurochem Res 40:661\u2013673. https:\/\/doi.org\/10.1007\/s11064-015-1513-5","journal-title":"Neurochem Res"},{"key":"1222_CR77","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/ptr.5541","volume":"30","author":"LL Qu","year":"2016","unstructured":"Qu LL, Yu B, Li Z, Jiang WX, Jiang JD, Kong WJ (2016) Gastrodin ameliorates oxidative stress and proinflammatory response in nonalcoholic fatty liver disease through the AMPK\/Nrf2 pathway. Phytother Res 30:402\u2013411. https:\/\/doi.org\/10.1002\/ptr.5541","journal-title":"Phytother Res"},{"key":"1222_CR78","doi-asserted-by":"publisher","first-page":"32147","DOI":"10.18632\/oncotarget.16740","volume":"8","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Zhou J, Song D, Sun Y, Liao C, Jiang X (2017) Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway. Oncotarget 8:32147\u201332156. https:\/\/doi.org\/10.18632\/oncotarget.16740","journal-title":"Oncotarget"},{"key":"1222_CR79","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.mito.2016.07.003","volume":"30","author":"M Picard","year":"2016","unstructured":"Picard M, Wallace DC, Burelle Y (2016) The rise of mitochondria in medicine. Mitochondrion 30:105\u2013116. https:\/\/doi.org\/10.1016\/j.mito.2016.07.003","journal-title":"Mitochondrion"},{"key":"1222_CR80","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/BF02816111","volume":"9","author":"K Iqbal","year":"1994","unstructured":"Iqbal K, Alonso AC, Gong CX, Khatoon S, Singh TJ, Grundke-Iqbal I (1994) Mechanism of neurofibrillary degeneration in Alzheimer\u2019s disease. Mol Neurobiol 9:119\u2013123","journal-title":"Mol Neurobiol"},{"key":"1222_CR81","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jns.2007.06.024","volume":"262","author":"A Elbaz","year":"2007","unstructured":"Elbaz A, Tranchant C (2007) Epidemiologic studies of environmental exposures in Parkinson\u2019s disease. J Neurol Sci 262:37\u201344","journal-title":"J Neurol Sci"},{"key":"1222_CR82","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1172\/JCI45364","volume":"121","author":"I Munoz-Sanjuan","year":"2011","unstructured":"Munoz-Sanjuan I, Bates GP (2011) The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease. J Clin Invest 121:476\u2013483. https:\/\/doi.org\/10.1172\/JCI45364","journal-title":"J Clin Invest"},{"key":"1222_CR83","doi-asserted-by":"publisher","first-page":"S299","DOI":"10.1007\/s00415-011-6040-y","volume":"258","author":"JB Schulz","year":"2011","unstructured":"Schulz JB, Gerlach M, Gille G, Kuhn W, M\u00fcngersdorf M, Riederer P, S\u00fcdmeyer M, Ludolph A (2011) Basic science in Parkinson\u2019s disease: its impact on clinical practice. J Neurol 258:S299\u2013S306. https:\/\/doi.org\/10.1007\/s00415-011-6040-y","journal-title":"J Neurol"},{"key":"1222_CR84","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.phrs.2018.03.010","volume":"131","author":"V Shoshan-Barmatz","year":"2018","unstructured":"Shoshan-Barmatz V, Nahon-Crystal E, Shteinfer-Kuzmine A, Gupta R (2018) VDAC1, mitochondrial dysfunction, and Alzheimer\u2019s disease. Pharmacol Res 131:87\u2013101. https:\/\/doi.org\/10.1016\/j.phrs.2018.03.010","journal-title":"Pharmacol Res"},{"key":"1222_CR85","doi-asserted-by":"publisher","first-page":"9326454","DOI":"10.1155\/2017\/9326454","volume":"2017","author":"M Kourti","year":"2017","unstructured":"Kourti M, Jiang WG, Cai J (2017) Aspects of carbon monoxide in form of CO-releasing molecules used in cancer treatment: more light on the way. Oxidative Med Cell Longev 2017:9326454. https:\/\/doi.org\/10.1155\/2017\/9326454","journal-title":"Oxidative Med Cell Longev"},{"key":"1222_CR86","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.phrs.2018.01.008","volume":"129","author":"K Magierowska","year":"2018","unstructured":"Magierowska K, Brzozowski T, Magierowski M (2018) Emerging role of carbon monoxide in regulation of cellular pathways and in the maintenance of gastric mucosal integrity. Pharmacol Res 129:56\u201364. https:\/\/doi.org\/10.1016\/j.phrs.2018.01.008","journal-title":"Pharmacol Res"},{"key":"1222_CR87","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.biotechadv.2017.12.012","volume":"36","author":"M Battino","year":"2018","unstructured":"Battino M, Giampieri F, Pistollato F, Sureda A, de Oliveira MR, Pittal\u00e0 V, Fallarino F, Nabavi SF et al (2018) Nrf2 as regulator of innate immunity: a molecular Swiss army knife! Biotechnol Adv 36:358\u2013370. https:\/\/doi.org\/10.1016\/j.biotechadv.2017.12.012","journal-title":"Biotechnol Adv"},{"key":"1222_CR88","doi-asserted-by":"publisher","unstructured":"de Oliveira MR, Brasil FB, F\u00fcrstenau CR (2018) Sulforaphane attenuated the pro-inflammatory state induced by hydrogen peroxide in SH-SY5Y cells through the Nrf2\/HO-1 signaling pathway. Neurotox Res (IN PRESS) https:\/\/doi.org\/10.1007\/s12640-018-9881-7","DOI":"10.1007\/s12640-018-9881-7"},{"key":"1222_CR89","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/S0753-3322(02)00205-6","volume":"56","author":"A Scalbert","year":"2002","unstructured":"Scalbert A, Morand C, Manach C, R\u00e9m\u00e9sy C (2002) Absorption and metabolism of polyphenols in the gut and impact on health. Biomed Pharmacother 56:276\u2013282","journal-title":"Biomed Pharmacother"},{"key":"1222_CR90","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1039\/c7fo00574a","volume":"8","author":"D Angelino","year":"2017","unstructured":"Angelino D, Cossu M, Marti A, Zanoletti M, Chiavaroli L, Brighenti F, Del Rio D, Martini D (2017) Bioaccessibility and bioavailability of phenolic compounds in bread: a review. Food Funct 8:2368\u20132393. https:\/\/doi.org\/10.1039\/c7fo00574a","journal-title":"Food Funct"},{"key":"1222_CR91","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/bph.13708","volume":"174","author":"K Goszcz","year":"2017","unstructured":"Goszcz K, Duthie GG, Stewart D, Leslie SJ, Megson IL (2017) Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response? Br J Pharmacol 174:1209\u20131225. https:\/\/doi.org\/10.1111\/bph.13708","journal-title":"Br J Pharmacol"},{"key":"1222_CR92","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1242\/bio.20134853","volume":"2","author":"KM Holmstr\u00f6m","year":"2013","unstructured":"Holmstr\u00f6m KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M et al (2013) Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biol Open 2:761\u2013770. https:\/\/doi.org\/10.1242\/bio.20134853","journal-title":"Biol Open"},{"key":"1222_CR93","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1042\/BJ20130863","volume":"457","author":"MH Ludtmann","year":"2014","unstructured":"Ludtmann MH, Angelova PR, Zhang Y, Abramov AY, Dinkova-Kostova AT (2014) Nrf2 affects the efficiency of mitochondrial fatty acid oxidation. Biochem J 457:415\u2013424. https:\/\/doi.org\/10.1042\/BJ20130863","journal-title":"Biochem J"},{"key":"1222_CR94","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","volume":"39","author":"JD Hayes","year":"2014","unstructured":"Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39:199\u2013218. https:\/\/doi.org\/10.1016\/j.tibs.2014.02.002","journal-title":"Trends Biochem Sci"},{"key":"1222_CR95","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","volume":"1","author":"KM Holmstr\u00f6m","year":"2016","unstructured":"Holmstr\u00f6m KM, Kostov RV, Dinkova-Kostova AT (2016) The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol 1:80\u201391. https:\/\/doi.org\/10.1016\/j.cotox.2016.10.002","journal-title":"Curr Opin Toxicol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1222-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1222-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1222-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T07:23:55Z","timestamp":1661585035000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1222-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":95,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1222"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1222-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]},"assertion":[{"value":"27 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}