{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:08:17Z","timestamp":1790795297408,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5R01AG042890"],"award-info":[{"award-number":["5R01AG042890"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Amon Carter Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12035-018-1248-9","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T17:28:38Z","timestamp":1534526918000},"page":"3341-3355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies"],"prefix":"10.1007","volume":"56","author":[{"given":"Michele M.","family":"Comerota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batbayar","family":"Tumurbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakez","family":"Kayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Taglialatela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"1248_CR1","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","volume":"27","author":"GM Shankar","year":"2007","unstructured":"Shankar GM, Bloodgood BL, Townsend M et al (2007) Natural oligomers of the Alzheimer amyloid- protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27:2866\u20132875. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.4970-06.2007","journal-title":"J Neurosci"},{"key":"1248_CR2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/alzrt217","volume":"5","author":"ME Orr","year":"2013","unstructured":"Orr ME, Oddo S (2013) Autophagic\/lysosomal dysfunction in Alzheimer\u2019s disease. Alzheimers Res Ther 5:53. \n                    https:\/\/doi.org\/10.1186\/alzrt217","journal-title":"Alzheimers Res Ther"},{"key":"1248_CR3","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bbadis.2013.09.010","volume":"1842","author":"RH Swerdlow","year":"2014","unstructured":"Swerdlow RH, Burns JM, Khan SM (2014) The Alzheimer\u2019s disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta (BBA) - Mol Basis Dis 1842:1219\u20131231. \n                    https:\/\/doi.org\/10.1016\/j.bbadis.2013.09.010","journal-title":"Biochim Biophys Acta (BBA) - Mol Basis Dis"},{"key":"1248_CR4","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, Khoury JE et al (2015) Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol 14:388\u2013405. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(15)70016-5","journal-title":"Lancet Neurol"},{"key":"1248_CR5","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/science.1074069","volume":"298","author":"DJ Selkoe","year":"2002","unstructured":"Selkoe DJ (2002) Alzheimer\u2019s disease is a synaptic failure. Science 298:789\u2013791. \n                    https:\/\/doi.org\/10.1126\/science.1074069","journal-title":"Science"},{"key":"1248_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15295","volume":"8","author":"L Zhou","year":"2017","unstructured":"Zhou L, McInnes J, Wierda K et al (2017) Tau association with synaptic vesicles causes presynaptic dysfunction. Nat Commun 8:15295. \n                    https:\/\/doi.org\/10.1038\/ncomms15295","journal-title":"Nat Commun"},{"key":"1248_CR7","doi-asserted-by":"publisher","unstructured":"F\u00e1 M, Puzzo D, Piacentini R et al (2016) Extracellular tau oligomers produce an immediate impairment of LTP and memory. Sci Rep 6. \n                    https:\/\/doi.org\/10.1038\/srep19393","DOI":"10.1038\/srep19393"},{"key":"1248_CR8","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","volume":"60","author":"P Giannakopoulos","year":"2003","unstructured":"Giannakopoulos P, Herrmann FR, Bussi\u00e8re T et al (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease. Neurology 60:1495\u20131500","journal-title":"Neurology"},{"key":"1248_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239\u2013259. \n                    https:\/\/doi.org\/10.1007\/BF00308809","journal-title":"Acta Neuropathol (Berl)"},{"key":"1248_CR10","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1096\/fj.11-199851","volume":"26","author":"CA Lasagna-Reeves","year":"2012","unstructured":"Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U et al (2012) Identification of oligomers at early stages of tau aggregation in Alzheimer\u2019s disease. FASEB J 26:1946\u20131959. \n                    https:\/\/doi.org\/10.1096\/fj.11-199851","journal-title":"FASEB J"},{"key":"1248_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neures.2005.11.009","volume":"54","author":"S Maeda","year":"2006","unstructured":"Maeda S, Sahara N, Saito Y et al (2006) Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer\u2019s disease. Neurosci Res 54:197\u2013201. \n                    https:\/\/doi.org\/10.1016\/j.neures.2005.11.009","journal-title":"Neurosci Res"},{"key":"1248_CR12","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.15252\/embj.201797724","volume":"36","author":"C Li","year":"2017","unstructured":"Li C, G\u00f6tz J (2017) Somatodendritic accumulation of tau in Alzheimer\u2019s disease is promoted by Fyn-mediated local protein translation. EMBO J 36:3120\u20133138. \n                    https:\/\/doi.org\/10.15252\/embj.201797724","journal-title":"EMBO J"},{"key":"1248_CR13","doi-asserted-by":"publisher","first-page":"14234","DOI":"10.1523\/JNEUROSCI.1523-15.2015","volume":"35","author":"M Usenovic","year":"2015","unstructured":"Usenovic M, Niroomand S, Drolet RE et al (2015) Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells. J Neurosci 35:14234\u201314250. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.1523-15.2015","journal-title":"J Neurosci"},{"key":"1248_CR14","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","volume":"82","author":"DW Sanders","year":"2014","unstructured":"Sanders DW, Kaufman SK, DeVos SL et al (2014) Distinct tau prion strains propagate in cells and mice and define different Tauopathies. Neuron 82:1271\u20131288. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2014.04.047","journal-title":"Neuron"},{"key":"1248_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/alzrt232","volume":"6","author":"S Purushothuman","year":"2014","unstructured":"Purushothuman S, Johnstone DM, Nandasena C et al (2014) Photobiomodulation with near infrared light mitigates Alzheimer\u2019s disease-related pathology in cerebral cortex \u2013 Evidence from two transgenic mouse models. Alzheimers Res Ther 6:2. \n                    https:\/\/doi.org\/10.1186\/alzrt232","journal-title":"Alzheimers Res Ther"},{"key":"1248_CR16","doi-asserted-by":"publisher","first-page":"15997","DOI":"10.1073\/pnas.0808084105","volume":"105","author":"LM Ittner","year":"2008","unstructured":"Ittner LM, Fath T, Ke YD et al (2008) Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci 105:15997\u201316002. \n                    https:\/\/doi.org\/10.1073\/pnas.0808084105","journal-title":"Proc Natl Acad Sci"},{"key":"1248_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jphotobiol.2013.02.015","volume":"123","author":"SL Grillo","year":"2013","unstructured":"Grillo SL, Duggett NA, Ennaceur A, Chazot PL (2013) Non-invasive infra-red therapy (1072nm) reduces \u03b2-amyloid protein levels in the brain of an Alzheimer\u2019s disease mouse model, TASTPM. J Photochem Photobiol B 123:13\u201322. \n                    https:\/\/doi.org\/10.1016\/j.jphotobiol.2013.02.015","journal-title":"J Photochem Photobiol B"},{"key":"1248_CR18","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3233\/JAD-2010-100894","volume":"23","author":"L De Taboada","year":"2011","unstructured":"De Taboada L, Yu J, El-Amouri S et al (2011) Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice. J Alzheimeraposs Dis 23:521\u2013535. \n                    https:\/\/doi.org\/10.3233\/JAD-2010-100894","journal-title":"J Alzheimeraposs Dis"},{"key":"1248_CR19","doi-asserted-by":"publisher","first-page":"15012","DOI":"10.1038\/s41598-017-15357-x","volume":"7","author":"MM Comerota","year":"2017","unstructured":"Comerota MM, Krishnan B, Taglialatela G (2017) Near infrared light decreases synaptic vulnerability to amyloid beta oligomers. Sci Rep 7:15012. \n                    https:\/\/doi.org\/10.1038\/s41598-017-15357-x","journal-title":"Sci Rep"},{"key":"1248_CR20","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","volume":"86","author":"C Andorfer","year":"2003","unstructured":"Andorfer C, Kress Y, Espinoza M et al (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86:582\u2013590","journal-title":"J Neurochem"},{"key":"1248_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1006\/nbdi.1999.0279","volume":"7","author":"K Duff","year":"2000","unstructured":"Duff K, Knight H, Refolo LM et al (2000) Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis 7:87\u201398. \n                    https:\/\/doi.org\/10.1006\/nbdi.1999.0279","journal-title":"Neurobiol Dis"},{"key":"1248_CR22","doi-asserted-by":"publisher","first-page":"S97","DOI":"10.3233\/JAD-132477","volume":"40","author":"DL Castillo-Carranza","year":"2014","unstructured":"Castillo-Carranza DL, Gerson JE, Sengupta U et al (2014) Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau Oligomeric seeds. J Alzheimers Dis 40:S97\u2013S111. \n                    https:\/\/doi.org\/10.3233\/JAD-132477","journal-title":"J Alzheimers Dis"},{"key":"1248_CR23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD et al (2003) Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409\u2013421","journal-title":"Neuron"},{"key":"1248_CR24","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1096\/fj.12-220889","volume":"27","author":"UK Jinwal","year":"2013","unstructured":"Jinwal UK, Akoury E, Abisambra JF et al (2013) Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J 27:1450\u20131459. \n                    https:\/\/doi.org\/10.1096\/fj.12-220889","journal-title":"FASEB J"},{"key":"1248_CR25","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s13311-014-0320-z","volume":"12","author":"LG Friedman","year":"2015","unstructured":"Friedman LG, Qureshi YH, Yu WH (2015) Promoting Autophagic clearance: viable therapeutic targets in Alzheimer\u2019s disease. Neurotherapeutics 12:94\u2013108. \n                    https:\/\/doi.org\/10.1007\/s13311-014-0320-z","journal-title":"Neurotherapeutics"},{"key":"1248_CR26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","volume":"140","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313\u2013326. \n                    https:\/\/doi.org\/10.1016\/j.cell.2010.01.028","journal-title":"Cell"},{"key":"1248_CR27","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/ana.410300410","volume":"30","author":"RD Terry","year":"1991","unstructured":"Terry RD, Masliah E, Salmon DP et al (1991) Physical basis of cognitive alterations in alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572\u2013580. \n                    https:\/\/doi.org\/10.1002\/ana.410300410","journal-title":"Ann Neurol"},{"key":"1248_CR28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1750-1326-6-39","volume":"6","author":"CA Lasagna-Reeves","year":"2011","unstructured":"Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U et al (2011) Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener 6:39. \n                    https:\/\/doi.org\/10.1186\/1750-1326-6-39","journal-title":"Mol Neurodegener"},{"key":"1248_CR29","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s40478-014-0146-2","volume":"2","author":"H-C Tai","year":"2014","unstructured":"Tai H-C, Wang BY, Serrano-Pozo A et al (2014) Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer\u2019s disease. Acta Neuropathol Commun 2:146. \n                    https:\/\/doi.org\/10.1186\/s40478-014-0146-2","journal-title":"Acta Neuropathol Commun"},{"key":"1248_CR30","doi-asserted-by":"publisher","first-page":"P603","DOI":"10.1016\/j.jalz.2017.07.249","volume":"13","author":"SN Fontaine","year":"2017","unstructured":"Fontaine SN, Nation G, Meier SE, Abisambra JF (2017) Tau oligomers mediate ribosomal dysfunction at the synapse. Alzheimers Dement 13:P603. \n                    https:\/\/doi.org\/10.1016\/j.jalz.2017.07.249","journal-title":"Alzheimers Dement"},{"key":"1248_CR31","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF00308912","volume":"80","author":"A Delacourte","year":"1990","unstructured":"Delacourte A, Flament S, Dibe EM et al (1990) Pathological proteins tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer\u2019s disease. Demonstration with a panel of antibodies against tau proteins. Acta Neuropathol (Berl) 80:111\u2013117","journal-title":"Acta Neuropathol (Berl)"},{"key":"1248_CR32","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.tins.2014.08.004","volume":"37","author":"H Zempel","year":"2014","unstructured":"Zempel H, Mandelkow E (2014) Lost after translation: missorting of tau protein and consequences for Alzheimer disease. Trends Neurosci 37:721\u2013732. \n                    https:\/\/doi.org\/10.1016\/j.tins.2014.08.004","journal-title":"Trends Neurosci"},{"key":"1248_CR33","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.neuroscience.2010.04.037","volume":"169","author":"HN Dawson","year":"2010","unstructured":"Dawson HN, Cantillana V, Jansen M et al (2010) Loss of tau elicits axonal degeneration in a mouse model of Alzheimer\u2019s disease. Neuroscience 169:516\u2013531. \n                    https:\/\/doi.org\/10.1016\/j.neuroscience.2010.04.037","journal-title":"Neuroscience"},{"key":"1248_CR34","doi-asserted-by":"publisher","unstructured":"Mirbaha H, Chen D, Morazova OA et al (2018) Inert and seed-competent tau monomers suggest structural origins of aggregation. eLife 7. \n                    https:\/\/doi.org\/10.7554\/eLife.36584","DOI":"10.7554\/eLife.36584"},{"key":"1248_CR35","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.bcp.2011.06.039","volume":"82","author":"HR Parri","year":"2011","unstructured":"Parri HR, Hernandez CM, Dineley KT (2011) Research update: alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer\u2019s disease. Biochem Pharmacol 82:931\u2013942. \n                    https:\/\/doi.org\/10.1016\/j.bcp.2011.06.039","journal-title":"Biochem Pharmacol"},{"key":"1248_CR36","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.neuron.2013.06.036","volume":"79","author":"JW Um","year":"2013","unstructured":"Um JW, Kaufman AC, Kostylev M et al (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer A\u03b2 oligomer bound to cellular prion protein. Neuron 79:887\u2013902. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2013.06.036","journal-title":"Neuron"},{"key":"1248_CR37","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1126\/science.1079469","volume":"300","author":"R Kayed","year":"2003","unstructured":"Kayed R (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486\u2013489. \n                    https:\/\/doi.org\/10.1126\/science.1079469","journal-title":"Science"},{"key":"1248_CR38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1089\/pho.2010.2789","volume":"28","author":"T Karu","year":"2010","unstructured":"Karu T (2010) Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg 28:159\u2013160. \n                    https:\/\/doi.org\/10.1089\/pho.2010.2789","journal-title":"Photomed Laser Surg"},{"key":"1248_CR39","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.3233\/JAD-170398","volume":"59","author":"MB Evgen\u2019ev","year":"2017","unstructured":"Evgen\u2019ev MB, Krasnov GS, Nesterova IV et al (2017) Molecular mechanisms underlying neuroprotective effect of intranasal administration of human Hsp70 in mouse model of Alzheimer\u2019s disease. J Alzheimers Dis 59:1415\u20131426. \n                    https:\/\/doi.org\/10.3233\/JAD-170398","journal-title":"J Alzheimers Dis"},{"key":"1248_CR40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12079-014-0243-9","volume":"8","author":"RK Leak","year":"2014","unstructured":"Leak RK (2014) Heat shock proteins in neurodegenerative disorders and aging. J Cell Commun Signal 8:293\u2013310. \n                    https:\/\/doi.org\/10.1007\/s12079-014-0243-9","journal-title":"J Cell Commun Signal"},{"key":"1248_CR41","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.chembiol.2016.04.014","volume":"23","author":"ZT Young","year":"2016","unstructured":"Young ZT, Rauch JN, Assimon VA et al (2016) Stabilizing the Hsp70-tau complex promotes turnover in models of Tauopathy. Cell Chem Biol 23:992\u20131001. \n                    https:\/\/doi.org\/10.1016\/j.chembiol.2016.04.014","journal-title":"Cell Chem Biol"},{"key":"1248_CR42","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1021\/acschembio.7b01039","volume":"13","author":"F Kundel","year":"2018","unstructured":"Kundel F, De S, Flagmeier P et al (2018) Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity. ACS Chem Biol 13:636\u2013646. \n                    https:\/\/doi.org\/10.1021\/acschembio.7b01039","journal-title":"ACS Chem Biol"},{"key":"1248_CR43","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/S0960-9822(01)00487-0","volume":"11","author":"J Demand","year":"2001","unstructured":"Demand J, Alberti S, Patterson C, H\u00f6hfeld J (2001) Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone\/proteasome coupling. Curr Biol CB 11:1569\u20131577","journal-title":"Curr Biol CB"},{"key":"1248_CR44","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jneumeth.2016.01.006","volume":"261","author":"W Franklin","year":"2016","unstructured":"Franklin W, Taglialatela G (2016) A method to determine insulin responsiveness in synaptosomes isolated from frozen brain tissue. J Neurosci Methods 261:128\u2013134. \n                    https:\/\/doi.org\/10.1016\/j.jneumeth.2016.01.006","journal-title":"J Neurosci Methods"},{"key":"1248_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002472","volume":"14","author":"YO Ali","year":"2016","unstructured":"Ali YO, Allen HM, Yu L et al (2016) NMNAT2:HSP90 complex mediates Proteostasis in Proteinopathies. PLoS Biol 14:e1002472. \n                    https:\/\/doi.org\/10.1371\/journal.pbio.1002472","journal-title":"PLoS Biol"},{"key":"1248_CR46","doi-asserted-by":"publisher","first-page":"10039","DOI":"10.1021\/bi1016233","volume":"49","author":"CA Lasagna-Reeves","year":"2010","unstructured":"Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Mu\u00f1oz MJ et al (2010) Preparation and characterization of neurotoxic tau oligomers. Biochemistry (Mosc) 49:10039\u201310041. \n                    https:\/\/doi.org\/10.1021\/bi1016233","journal-title":"Biochemistry (Mosc)"},{"key":"1248_CR47","doi-asserted-by":"publisher","unstructured":"Dineley KT, Kayed R, Neugebauer V et al (2010) Amyloid-\u03b2 oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice. J Neurosci Res. \n                    https:\/\/doi.org\/10.1002\/jnr.22445","DOI":"10.1002\/jnr.22445"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1248-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T13:27:24Z","timestamp":1589894844000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1248-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,17]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1248"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1248-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,17]]},"assertion":[{"value":"8 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}