{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:24:46Z","timestamp":1758403486564,"version":"3.37.3"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T00:00:00Z","timestamp":1534550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"European Union's Horizon 2020 research and innovation program, Future Emerging Technologies (FET) open","award":["686841"],"award-info":[{"award-number":["686841"]}]},{"name":"European Union's Horizon 2020 research and innovation program, Future Emerging Technologies (FET) open","award":["686841"],"award-info":[{"award-number":["686841"]}]},{"name":"European Union's Horizon 2020 research and innovation program, Future Emerging Technologies (FET) open","award":["686841"],"award-info":[{"award-number":["686841"]}]},{"name":"Intramural Program of the National Institute of Allergy and Infectious Diseases, NIH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12035-018-1311-6","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T14:58:24Z","timestamp":1534604304000},"page":"3393-3403","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells"],"prefix":"10.1007","volume":"56","author":[{"given":"Dennis","family":"Paliga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Raudzus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-2655","authenticated-orcid":false,"given":"Rolf","family":"Heumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,18]]},"reference":[{"issue":"5","key":"1311_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1210\/edrv.20.5.0378","volume":"20","author":"V Giguere","year":"1999","unstructured":"Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20(5):689\u2013725. https:\/\/doi.org\/10.1210\/edrv.20.5.0378","journal-title":"Endocr Rev"},{"issue":"41","key":"1311_CR2","doi-asserted-by":"publisher","first-page":"69731","DOI":"10.18632\/oncotarget.19227","volume":"8","author":"J Liu","year":"2017","unstructured":"Liu J, Wang GH, Duan YH, Dai Y, Bao Y, Hu M, Zhou YQ, Li M et al (2017) Modulation of the Nur77-Bcl-2 apoptotic pathway by p38alpha MAPK. Oncotarget 8(41):69731\u201369745. https:\/\/doi.org\/10.18632\/oncotarget.19227","journal-title":"Oncotarget"},{"issue":"4","key":"1311_CR3","doi-asserted-by":"publisher","first-page":"626","DOI":"10.7150\/jca.17579","volume":"8","author":"M Yi","year":"2017","unstructured":"Yi M, Yang J, Li W, Li X, Xiong W, McCarthy JB, Li G, Xiang B (2017) The NOR1\/OSCP1 proteins in cancer: from epigenetic silencing to functional characterization of a novel tumor suppressor. J Cancer 8(4):626\u2013635. https:\/\/doi.org\/10.7150\/jca.17579","journal-title":"J Cancer"},{"issue":"9","key":"1311_CR4","doi-asserted-by":"publisher","first-page":"5876","DOI":"10.1007\/s12035-015-9477-7","volume":"53","author":"XB Wei","year":"2016","unstructured":"Wei XB, Gao HM, Zou J, Liu X, Chen D, Liao JC, Xu YQ, Ma L et al (2016) Contra-directional coupling of Nur77 and Nurr1 in neurodegeneration: a novel mechanism for memantine-induced anti-inflammation and anti-mitochondrial impairment. Mol Neurobiol 53(9):5876\u20135892. https:\/\/doi.org\/10.1007\/s12035-015-9477-7","journal-title":"Mol Neurobiol"},{"issue":"1\u20132","key":"1311_CR5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.pneurobio.2005.09.001","volume":"77","author":"J Jankovic","year":"2005","unstructured":"Jankovic J, Chen S, Le WD (2005) The role of Nurr1 in the development of dopaminergic neurons and Parkinson\u2019s disease. Prog Neurobiol 77(1\u20132):128\u2013138. https:\/\/doi.org\/10.1016\/j.pneurobio.2005.09.001","journal-title":"Prog Neurobiol"},{"issue":"7","key":"1311_CR6","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1073\/pnas.95.7.4013","volume":"95","author":"O Saucedo-Cardenas","year":"1998","unstructured":"Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ, DeMayo F, Burbach JPH, Conneely OM (1998) Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A 95(7):4013\u20134018. https:\/\/doi.org\/10.1073\/pnas.95.7.4013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"1311_CR7","doi-asserted-by":"publisher","first-page":"12747","DOI":"10.1073\/pnas.1534900100","volume":"100","author":"GA Castelo-Branco","year":"2003","unstructured":"Castelo-Branco GA, Wagner J, Rodriguez FJ, Kele J, Sousa K, Rawal N, Pasolli HA, Fuchs E et al (2003) Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A 100(22):12747\u201312752. https:\/\/doi.org\/10.1073\/pnas.1534900100","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1311_CR8","doi-asserted-by":"publisher","first-page":"a008888","DOI":"10.1101\/cshperspect.a008888","volume":"2","author":"C Klein","year":"2012","unstructured":"Klein C, Westenberger A (2012) Genetics of Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2(1):a008888. https:\/\/doi.org\/10.1101\/cshperspect.a008888","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"3","key":"1311_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/cne.10261","volume":"450","author":"Y Chu","year":"2002","unstructured":"Chu Y, Kompoliti K, Cochran EJ, Mufson EJ, Kordower JH (2002) Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. J Comp Neurol 450(3):203\u2013214. https:\/\/doi.org\/10.1002\/cne.10261","journal-title":"J Comp Neurol"},{"issue":"4","key":"1311_CR10","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.bbrc.2016.12.034","volume":"482","author":"W Liu","year":"2017","unstructured":"Liu W, Gao Y, Chang N (2017) Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson\u2019s disease models. Biochem Biophys Res Commun 482(4):1312\u20131319. https:\/\/doi.org\/10.1016\/j.bbrc.2016.12.034","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"1311_CR11","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/cns.12536","volume":"22","author":"J Dong","year":"2016","unstructured":"Dong J, Li S, Mo JL, Cai HB, Le WD (2016) Nurr1-based therapies for Parkinson\u2019s disease. CNS Neurosci Ther 22(5):351\u2013359. https:\/\/doi.org\/10.1111\/cns.12536","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"1311_CR12","doi-asserted-by":"publisher","first-page":"510","DOI":"10.15252\/emmm.201404610","volume":"7","author":"SM Oh","year":"2015","unstructured":"Oh SM, Chang MY, Song JJ, Rhee YH, Joe EH, Lee HS, Yi SH, Lee SH (2015) Combined Nurr1 and Foxa2 roles in the therapy of Parkinson\u2019s disease. EMBO Mol Med 7(5):510\u2013525. https:\/\/doi.org\/10.15252\/emmm.201404610","journal-title":"EMBO Mol Med"},{"issue":"7","key":"1311_CR13","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.18632\/oncotarget.7191","volume":"7","author":"J Wang","year":"2016","unstructured":"Wang J, Bi W, Zhao W, Varghese M, Koch RJ, Walker RH, Chandraratna RA, Sanders ME et al (2016) Selective brain penetrable Nurr1 transactivator for treating Parkinson\u2019s disease. Oncotarget 7(7):7469\u20137479. https:\/\/doi.org\/10.18632\/oncotarget.7191","journal-title":"Oncotarget"},{"key":"1311_CR14","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/B978-0-12-382219-2.00282-9","volume-title":"Handbook of Proteolytic Enzymes","author":"Stephen H. Leppla","year":"2013","unstructured":"Leppla SH (2013) Chapter 281 - Anthrax lethal factor A2 - Rawlings, Neil D. In: Salvesen G (ed) Handbook of proteolytic enzymes. Academic Press, pp 1257\u20131261. https:\/\/doi.org\/10.1016\/B978-0-12-382219-2.00282-9"},{"issue":"1","key":"1311_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/toxins5010001","volume":"5","author":"SH Liu","year":"2013","unstructured":"Liu SH, Zhang Y, Hoover B, Leppla SH (2013) The receptors that mediate the direct lethality of anthrax toxin. Toxins 5(1):1\u20138. https:\/\/doi.org\/10.3390\/toxins5010001","journal-title":"Toxins"},{"issue":"3","key":"1311_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jmb.2009.07.037","volume":"392","author":"AF Kintzer","year":"2009","unstructured":"Kintzer AF, Thoren KL, Sterling HJ, Dong KC, Feld GK, Tang II, Zhang TT, Williams ER et al (2009) The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol 392(3):614\u2013629. https:\/\/doi.org\/10.1016\/j.jmb.2009.07.037","journal-title":"J Mol Biol"},{"issue":"31","key":"1311_CR17","doi-asserted-by":"publisher","first-page":"18626","DOI":"10.1074\/jbc.270.31.18626","volume":"270","author":"J Zhao","year":"1995","unstructured":"Zhao J, Milne JC, Collier RJ (1995) Effect of anthrax toxin\u2019s lethal factor on ion channels formed by the protective antigen. J Biol Chem 270(31):18626\u201318630. https:\/\/doi.org\/10.1074\/jbc.270.31.18626","journal-title":"J Biol Chem"},{"issue":"7553","key":"1311_CR18","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nature14247","volume":"521","author":"J Jiang","year":"2015","unstructured":"Jiang J, Pentelute BL, Collier RJ, Zhou ZH (2015) Atomic structure of anthrax protective antigen pore elucidates toxin translocation. Nature 521(7553):545\u2013549. https:\/\/doi.org\/10.1038\/nature14247","journal-title":"Nature"},{"issue":"5","key":"1311_CR19","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/j.1365-2958.2011.07770.x","volume":"81","author":"AG Tamayo","year":"2011","unstructured":"Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR (2011) GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol 81(5):1390\u20131401. https:\/\/doi.org\/10.1111\/j.1365-2958.2011.07770.x","journal-title":"Mol Microbiol"},{"issue":"22","key":"1311_CR20","doi-asserted-by":"crossref","first-page":"15542","DOI":"10.1016\/S0021-9258(19)49569-0","volume":"267","author":"N Arora","year":"1992","unstructured":"Arora N, Klimpel KR, Singh Y, Leppla SH (1992) Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin-a are potent cytotoxins which are translocated to the cytosol of mammalian-cells. J Biol Chem 267(22):15542\u201315548","journal-title":"J Biol Chem"},{"issue":"5","key":"1311_CR21","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1016\/S0021-9258(18)53698-X","volume":"268","author":"N Arora","year":"1993","unstructured":"Arora N, Leppla SH (1993) Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides. J Biol Chem 268(5):3334\u20133341","journal-title":"J Biol Chem"},{"issue":"2","key":"1311_CR22","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1086\/338448","volume":"185","author":"H Cao","year":"2002","unstructured":"Cao H, Agrawal D, Kushner N, Touzjian N, Essex M, Lu Y (2002) Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol. J Infect Dis 185(2):244\u2013251. https:\/\/doi.org\/10.1086\/338448","journal-title":"J Infect Dis"},{"issue":"11","key":"1311_CR23","doi-asserted-by":"publisher","first-page":"6652","DOI":"10.1073\/pnas.1131930100","volume":"100","author":"N Kushner","year":"2003","unstructured":"Kushner N, Zhang D, Touzjian N, Essex M, Lieberman J, Lu YC (2003) A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen. Proc Natl Acad Sci U S A 100(11):6652\u20136657. https:\/\/doi.org\/10.1073\/pnas.1131930100","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"32","key":"1311_CR24","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.1016\/j.vaccine.2005.03.022","volume":"23","author":"K McEvers","year":"2005","unstructured":"McEvers K, Elrefaei M, Norris P, Deeks S, Martin J, Lu Y, Cao H (2005) Modified anthrax fusion proteins deliver HIV antigens through MHC class I and II pathways. Vaccine 23(32):4128\u20134135. https:\/\/doi.org\/10.1016\/j.vaccine.2005.03.022","journal-title":"Vaccine"},{"issue":"6","key":"1311_CR25","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1128\/Iai.01718-07","volume":"76","author":"CA Shaw","year":"2008","unstructured":"Shaw CA, Starnbach MN (2008) Both CD4(+) and CD8(+) T cells respond to antigens fused to anthrax lethal toxin. Infect Immun 76(6):2603\u20132611. https:\/\/doi.org\/10.1128\/Iai.01718-07","journal-title":"Infect Immun"},{"issue":"1","key":"1311_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1515\/bmc-2016-0030","volume":"8","author":"A Pichler","year":"2017","unstructured":"Pichler A, Fatouros C, Lee H, Eisenhardt N (2017) SUMO conjugation - a mechanistic view. Biomol Concepts 8(1):13\u201336. https:\/\/doi.org\/10.1515\/bmc-2016-0030","journal-title":"Biomol Concepts"},{"issue":"1","key":"1311_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1110\/ps.051812706","volume":"15","author":"JG Marblestone","year":"2006","unstructured":"Marblestone JG, Edavettal SC, Lim Y, Lim P, Zuo X, Butt TR (2006) Comparison of SUMO fusion technology with traditional gene fusion systems: enhanced expression and solubility with SUMO. Protein Sci 15(1):182\u2013189. https:\/\/doi.org\/10.1110\/ps.051812706","journal-title":"Protein Sci"},{"key":"1311_CR28","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0076-6879(05)99051-4","volume":"399","author":"A Varshavsky","year":"2005","unstructured":"Varshavsky A (2005) Ubiquitin fusion technique and related methods. Methods Enzymol 399:777\u2013799. https:\/\/doi.org\/10.1016\/S0076-6879(05)99051-4","journal-title":"Methods Enzymol"},{"issue":"6","key":"1311_CR29","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.molcel.2006.02.008","volume":"21","author":"PS Brzovic","year":"2006","unstructured":"Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE (2006) A UbcH5\/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol Cell 21(6):873\u2013880. https:\/\/doi.org\/10.1016\/j.molcel.2006.02.008","journal-title":"Mol Cell"},{"issue":"1","key":"1311_CR30","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","volume":"18","author":"CT Rueden","year":"2017","unstructured":"Rueden CT, Schindelin J, Hiner MC, DeZonia BE, Walter AE, Arena ET, Eliceiri KW (2017) ImageJ2: ImageJ for the next generation of scientific image data. BMC Bioinformatics 18(1):529. https:\/\/doi.org\/10.1186\/s12859-017-1934-z","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"1311_CR31","doi-asserted-by":"publisher","first-page":"e00201","DOI":"10.1128\/mBio.00201-13","volume":"4","author":"C Bachran","year":"2013","unstructured":"Bachran C, Morley T, Abdelazim S, Fattah RJ, Liu S, Leppla SH (2013) Anthrax toxin-mediated delivery of the Pseudomonas exotoxin A enzymatic domain to the cytosol of tumor cells via cleavable ubiquitin fusions. MBio 4(3):e00201\u2013e00213. https:\/\/doi.org\/10.1128\/mBio.00201-13","journal-title":"MBio"},{"key":"1311_CR32","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev.biochem.73.011303.074118","volume":"73","author":"ES Johnson","year":"2004","unstructured":"Johnson ES (2004) Protein modification by SUMO. Annu Rev Biochem 73:355\u2013382. https:\/\/doi.org\/10.1146\/annurev.biochem.73.011303.074118","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"1311_CR33","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1111\/j.1460-9568.2007.05457.x","volume":"25","author":"K Chakrabarty","year":"2007","unstructured":"Chakrabarty K, Serchov T, Mann SA, Dietzel ID, Heumann R (2007) Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. Eur J Neurosci 25(7):1971\u20131981. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05457.x","journal-title":"Eur J Neurosci"},{"issue":"4","key":"1311_CR34","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/jnr.490260405","volume":"26","author":"PP Michel","year":"1990","unstructured":"Michel PP, Hefti F (1990) Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture. J Neurosci Res 26(4):428\u2013435. https:\/\/doi.org\/10.1002\/jnr.490260405","journal-title":"J Neurosci Res"},{"key":"1311_CR35","doi-asserted-by":"publisher","first-page":"260","DOI":"10.12688\/f1000research.10100.1","volume":"6","author":"WH Oertel","year":"2017","unstructured":"Oertel WH (2017) Recent advances in treating Parkinson\u2019s disease. F1000Res 6:260. https:\/\/doi.org\/10.12688\/f1000research.10100.1","journal-title":"F1000Res"},{"issue":"2","key":"1311_CR36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1001\/archneurol.2010.260","volume":"68","author":"JM Bronstein","year":"2011","unstructured":"Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS et al (2011) Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol 68(2):165. https:\/\/doi.org\/10.1001\/archneurol.2010.260","journal-title":"Arch Neurol"},{"issue":"4","key":"1311_CR37","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/jnc.12751","volume":"130","author":"R Heumann","year":"2014","unstructured":"Heumann R, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Colin R, Garcia-Montes JR, Simola N, Morelli M (2014) Dyskinesia in Parkinson\u2019s disease: mechanisms and current non-pharmacological interventions. J Neurochem 130(4):472\u2013489. https:\/\/doi.org\/10.1111\/jnc.12751","journal-title":"J Neurochem"},{"issue":"1","key":"1311_CR38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5966\/sctm.2014-0078","volume":"4","author":"J Muller","year":"2015","unstructured":"Muller J, Ossig C, Greiner JF, Hauser S, Fauser M, Widera D, Kaltschmidt C, Storch A et al (2015) Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats. Stem Cells Transl Med 4(1):31\u201343. https:\/\/doi.org\/10.5966\/sctm.2014-0078","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"1311_CR39","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ijdevneu.2012.10.007","volume":"31","author":"X Tan","year":"2013","unstructured":"Tan X, Zhang L, Qin J, Tian M, Zhu H, Dong C, Zhao H, Jin G (2013) Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of parkinsonian rats. Int J Dev Neurosci 31(1):82\u201387. https:\/\/doi.org\/10.1016\/j.ijdevneu.2012.10.007","journal-title":"Int J Dev Neurosci"},{"issue":"11","key":"1311_CR40","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.3727\/096368914X685078","volume":"24","author":"TL Ko","year":"2015","unstructured":"Ko TL, Fu YY, Shih YH, Lin YH, Ko MH, Fu TW, Lin TY, Hsiao HS et al (2015) A high-efficiency induction of dopaminergic cells from human umbilical mesenchymal stem cells for the treatment of hemiparkinsonian rats. Cell Transplant 24(11):2251\u20132262. https:\/\/doi.org\/10.3727\/096368914X685078","journal-title":"Cell Transplant"},{"issue":"7359","key":"1311_CR41","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nature10284","volume":"476","author":"M Caiazzo","year":"2011","unstructured":"Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D, Sotnikova TD, Menegon A et al (2011) Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476(7359):224\u2013227. https:\/\/doi.org\/10.1038\/nature10284","journal-title":"Nature"},{"issue":"28","key":"1311_CR42","doi-asserted-by":"publisher","first-page":"17401","DOI":"10.1074\/jbc.M114.629808","volume":"290","author":"MS Lim","year":"2015","unstructured":"Lim MS, Chang MY, Kim SM, Yi SH, Suh-Kim H, Jung SJ, Kim MJ, Kim JH et al (2015) Generation of dopamine neurons from rodent fibroblasts through the expandable neural precursor cell stage. J Biol Chem 290(28):17401\u201317414. https:\/\/doi.org\/10.1074\/jbc.M114.629808","journal-title":"J Biol Chem"},{"issue":"5","key":"1311_CR43","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nrg1066","volume":"4","author":"CE Thomas","year":"2003","unstructured":"Thomas CE, Ehrhardt A, Kay MA (2003) Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4(5):346\u2013358. https:\/\/doi.org\/10.1038\/nrg1066","journal-title":"Nat Rev Genet"},{"issue":"3","key":"1311_CR44","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/j.1471-4159.2007.05204.x","volume":"105","author":"F Nagel","year":"2008","unstructured":"Nagel F, Falkenburger BH, Tonges L, Kowsky S, Poppelmeyer C, Schulz JB, Bahr M, Dietz GP (2008) Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson\u2019s disease. J Neurochem 105(3):853\u2013864. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.05204.x","journal-title":"J Neurochem"},{"issue":"4","key":"1311_CR45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.bbrc.2015.02.166","volume":"459","author":"F Mirakhori","year":"2015","unstructured":"Mirakhori F, Zeynali B, Rassouli H, Salekdeh GH, Baharvand H (2015) Direct conversion of human fibroblasts into dopaminergic neural progenitor-like cells using TAT-mediated protein transduction of recombinant factors. Biochem Biophys Res Commun 459(4):655\u2013661. https:\/\/doi.org\/10.1016\/j.bbrc.2015.02.166","journal-title":"Biochem Biophys Res Commun"},{"key":"1311_CR46","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.peptides.2016.11.011","volume":"87","author":"A Bolhassani","year":"2017","unstructured":"Bolhassani A, Jafarzade BS, Mardani G (2017) In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides. Peptides 87:50\u201363. https:\/\/doi.org\/10.1016\/j.peptides.2016.11.011","journal-title":"Peptides"},{"key":"1311_CR47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bcp.2017.04.009","volume":"142","author":"GL Beilhartz","year":"2017","unstructured":"Beilhartz GL, Sugiman-Marangos SN, Melnyk RA (2017) Repurposing bacterial toxins for intracellular delivery of therapeutic proteins. Biochem Pharmacol 142:13\u201320. https:\/\/doi.org\/10.1016\/j.bcp.2017.04.009","journal-title":"Biochem Pharmacol"},{"issue":"32","key":"1311_CR48","doi-asserted-by":"publisher","first-page":"33534","DOI":"10.18632\/oncotarget.5214","volume":"6","author":"EW Martin","year":"2015","unstructured":"Martin EW, Buzza MS, Driesbaugh KH, Liu S, Fortenberry YM, Leppla SH, Antalis TM (2015) Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden. Oncotarget 6(32):33534\u201333553. https:\/\/doi.org\/10.18632\/oncotarget.5214","journal-title":"Oncotarget"},{"issue":"7","key":"1311_CR49","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/toxins8070197","volume":"8","author":"Christopher Bachran","year":"2016","unstructured":"Bachran C, Leppla SH (2016) Tumor targeting and drug delivery by anthrax toxin. Toxins (Basel) 8(7). https:\/\/doi.org\/10.3390\/toxins8070197","journal-title":"Toxins"},{"issue":"1","key":"1311_CR50","doi-asserted-by":"publisher","first-page":"13194","DOI":"10.1038\/s41598-017-13469-y","volume":"7","author":"WPR Verdurmen","year":"2017","unstructured":"Verdurmen WPR, Mazlami M, Pluckthun A (2017) A quantitative comparison of cytosolic delivery via different protein uptake systems. Sci Rep 7(1):13194. https:\/\/doi.org\/10.1038\/s41598-017-13469-y","journal-title":"Sci Rep"},{"issue":"3","key":"1311_CR51","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s12031-011-9642-z","volume":"46","author":"JB Eells","year":"2012","unstructured":"Eells JB, Wilcots J, Sisk S, Guo-Ross SX (2012) NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes. J Mol Neurosci 46(3):545\u2013553. https:\/\/doi.org\/10.1007\/s12031-011-9642-z","journal-title":"J Mol Neurosci"},{"issue":"4","key":"1311_CR52","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.neuint.2010.01.005","volume":"56","author":"H No","year":"2010","unstructured":"No H, Bang Y, Lim J, Kim SS, Choi HS, Choi HJ (2010) Involvement of induction and mitochondrial targeting of orphan nuclear receptor Nur77 in 6-OHDA-induced SH-SY5Y cell death. Neurochem Int 56(4):620\u2013626. https:\/\/doi.org\/10.1016\/j.neuint.2010.01.005","journal-title":"Neurochem Int"},{"key":"1311_CR53","doi-asserted-by":"publisher","first-page":"ARTN 34403","DOI":"10.1038\/srep34403","volume":"6","author":"HM Gao","year":"2016","unstructured":"Gao HM, Chen ZY, Fu YM, Yang XY, Weng RH, Wang R, Lu JJ, Pan MQ et al (2016) Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress. Sci Rep Uk 6:ARTN 34403. https:\/\/doi.org\/10.1038\/srep34403","journal-title":"Sci Rep Uk"},{"issue":"11","key":"1311_CR54","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrneurol.2013.209","volume":"9","author":"M Decressac","year":"2013","unstructured":"Decressac M, Volakakis N, Bjorklund A, Perlmann T (2013) NURR1 in Parkinson disease--from pathogenesis to therapeutic potential. Nat Rev Neurol 9(11):629\u2013636. https:\/\/doi.org\/10.1038\/nrneurol.2013.209","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"1311_CR55","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1046\/j.1471-4159.2003.01671.x","volume":"85","author":"KS Kim","year":"2003","unstructured":"Kim KS, Kim CH, Hwang DY, Seo H, Chung S, Hong SJ, Lim JK, Anderson T et al (2003) Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J Neurochem 85(3):622\u2013634","journal-title":"J Neurochem"},{"issue":"12","key":"1311_CR56","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/syn.20449","volume":"61","author":"QJ Li","year":"2007","unstructured":"Li QJ, Tang YM, Liu J, Zhou DY, Li XP, Xiao SH, Jian DX, Xing YG (2007) Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene. Synapse 61(12):971\u2013977. https:\/\/doi.org\/10.1002\/syn.20449","journal-title":"Synapse"},{"issue":"22","key":"1311_CR57","doi-asserted-by":"publisher","first-page":"12531","DOI":"10.1073\/pnas.93.22.12531","volume":"93","author":"JD Ballard","year":"1996","unstructured":"Ballard JD, Collier RJ, Starnbach MN (1996) Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc Natl Acad Sci U S A 93(22):12531\u201312534. https:\/\/doi.org\/10.1073\/pnas.93.22.12531","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1311_CR58","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/IAI.66.2.615-619.1998","volume":"66","author":"JD Ballard","year":"1998","unstructured":"Ballard JD, Doling AM, Beauregard K, Collier RJ, Starnbach MN (1998) Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin. Infect Immun 66(2):615\u2013619","journal-title":"Infect Immun"},{"issue":"3","key":"1311_CR59","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.cell.2015.03.028","volume":"161","author":"DS D'Astolfo","year":"2015","unstructured":"D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H et al (2015) Efficient intracellular delivery of native proteins. Cell 161(3):674\u2013690. https:\/\/doi.org\/10.1016\/j.cell.2015.03.028","journal-title":"Cell"},{"issue":"8","key":"1311_CR60","doi-asserted-by":"publisher","first-page":"5506","DOI":"10.1074\/jbc.M112.439190","volume":"288","author":"AJ Garcia-Yague","year":"2013","unstructured":"Garcia-Yague AJ, Rada P, Rojo AI, Lastres-Becker I, Cuadrado A (2013) Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. J Biol Chem 288(8):5506\u20135517. https:\/\/doi.org\/10.1074\/jbc.M112.439190","journal-title":"J Biol Chem"},{"issue":"5","key":"1311_CR61","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.cell.2010.11.026","volume":"143","author":"S Creton","year":"2010","unstructured":"Creton S, Jentsch S (2010) Snapshot: the SUMO system. Cell 143(5):848\u2013 e841. https:\/\/doi.org\/10.1016\/j.cell.2010.11.026","journal-title":"Cell"},{"issue":"4","key":"1311_CR62","doi-asserted-by":"publisher","first-page":"e381","DOI":"10.1371\/journal.pone.0000381","volume":"2","author":"A Catic","year":"2007","unstructured":"Catic A, Misaghi S, Korbel GA, Ploegh HL (2007) ElaD, a deubiquitinating protease expressed by E. coli. PLoS One 2(4):e381. https:\/\/doi.org\/10.1371\/journal.pone.0000381","journal-title":"PLoS One"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1311-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1311-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1311-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T19:23:24Z","timestamp":1661801004000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1311-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,18]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1311"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1311-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"type":"print","value":"0893-7648"},{"type":"electronic","value":"1559-1182"}],"subject":[],"published":{"date-parts":[[2018,8,18]]},"assertion":[{"value":"16 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}