{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:23Z","timestamp":1791499523925,"version":"4.3.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["2P30MH062261"],"award-info":[{"award-number":["2P30MH062261"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nebraska Center for Substance Abuse Research"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA035203"],"award-info":[{"award-number":["DA035203"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA040397"],"award-info":[{"award-number":["DA040397"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA041751"],"award-info":[{"award-number":["DA041751"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA044586"],"award-info":[{"award-number":["DA044586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA043138"],"award-info":[{"award-number":["DA043138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12035-018-1325-0","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T14:42:35Z","timestamp":1535380955000},"page":"3576-3590","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes"],"prefix":"10.1007","volume":"56","author":[{"given":"Susmita","family":"Sil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palsamy","family":"Periyasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-6685","authenticated-orcid":false,"given":"Shilpa","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"issue":"6","key":"1325_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nrn.2016.39","volume":"17","author":"ME Wolf","year":"2016","unstructured":"Wolf ME (2016) Synaptic mechanisms underlying persistent cocaine craving. Nat Rev Neurosci 17(6):351\u2013365. https:\/\/doi.org\/10.1038\/nrn.2016.39","journal-title":"Nat Rev Neurosci"},{"issue":"2\u20133","key":"1325_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0378-8741(81)90063-5","volume":"3","author":"G Barnett","year":"1981","unstructured":"Barnett G, Hawks R, Resnick R (1981) Cocaine pharmacokinetics in humans. J Ethnopharmacol 3(2\u20133):353\u2013366","journal-title":"J Ethnopharmacol"},{"key":"1325_CR3","unstructured":"CBHSQ CfBHSaQ (2011) Drug abuse warning network: 2011: selected tables of national estimates of drug-related emergency department visits. Substance Abuse and Mental Health Services Administration"},{"issue":"8","key":"1325_CR4","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1182\/blood-2010-10-313593","volume":"117","author":"H Yao","year":"2011","unstructured":"Yao H, Duan M, Buch S (2011) Cocaine-mediated induction of platelet-derived growth factor: Implication for increased vascular permeability. Blood 117(8):2538\u20132547. https:\/\/doi.org\/10.1182\/blood-2010-10-313593","journal-title":"Blood"},{"issue":"16","key":"1325_CR5","doi-asserted-by":"publisher","first-page":"5942","DOI":"10.1523\/JNEUROSCI.5618-10.2011","volume":"31","author":"H Yao","year":"2011","unstructured":"Yao H, Kim K, Duan M, Hayashi T, Guo M, Morgello S, Prat A, Wang J et al (2011) Cocaine hijacks sigma1 receptor to initiate induction of activated leukocyte cell adhesion molecule: implication for increased monocyte adhesion and migration in the CNS. J Neurosci 31(16):5942\u20135955. https:\/\/doi.org\/10.1523\/JNEUROSCI.5618-10.2011","journal-title":"J Neurosci"},{"issue":"4","key":"1325_CR6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s11481-011-9297-0","volume":"6","author":"S Buch","year":"2011","unstructured":"Buch S, Yao H, Guo M, Mori T, Su TP, Wang J (2011) Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction. J NeuroImmune Pharmacol 6(4):503\u2013515. https:\/\/doi.org\/10.1007\/s11481-011-9297-0","journal-title":"J NeuroImmune Pharmacol"},{"key":"1325_CR7","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.3389\/fmicb.2015.01111","volume":"6","author":"S Dash","year":"2015","unstructured":"Dash S, Balasubramaniam M, Villalta F, Dash C, Pandhare J (2015) Impact of cocaine abuse on HIV pathogenesis. Front Microbiol 6:1111. https:\/\/doi.org\/10.3389\/fmicb.2015.01111","journal-title":"Front Microbiol"},{"issue":"2","key":"1325_CR8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/pr.57.2.4","volume":"57","author":"BT Hawkins","year":"2005","unstructured":"Hawkins BT, Davis TP (2005) The blood-brain barrier\/neurovascular unit in health and disease. Pharmacol Rev 57(2):173\u2013185. https:\/\/doi.org\/10.1124\/pr.57.2.4","journal-title":"Pharmacol Rev"},{"issue":"1","key":"1325_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s11481-007-9091-1","volume":"3","author":"NK Dhillon","year":"2008","unstructured":"Dhillon NK, Peng F, Bokhari S, Callen S, Shin SH, Zhu X, Kim KJ, Buch SJ (2008) Cocaine-mediated alteration in tight junction protein expression and modulation of CCL2\/CCR2 axis across the blood-brain barrier: Implications for HIV-dementia. J NeuroImmune Pharmacol 3(1):52\u201356. https:\/\/doi.org\/10.1007\/s11481-007-9091-1","journal-title":"J NeuroImmune Pharmacol"},{"issue":"2","key":"1325_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1006\/exmp.1999.2253","volume":"66","author":"FD Kolodgie","year":"1999","unstructured":"Kolodgie FD, Wilson PS, Mergner WJ, Virmani R (1999) Cocaine-induced increase in the permeability function of human vascular endothelial cell monolayers. Exp Mol Pathol 66(2):109\u2013122. https:\/\/doi.org\/10.1006\/exmp.1999.2253","journal-title":"Exp Mol Pathol"},{"key":"1325_CR11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0074-7742(09)88011-2","volume":"88","author":"HS Sharma","year":"2009","unstructured":"Sharma HS, Muresanu D, Sharma A, Patnaik R (2009) Cocaine-induced breakdown of the blood-brain barrier and neurotoxicity. Int Rev Neurobiol 88:297\u2013334. https:\/\/doi.org\/10.1016\/S0074-7742(09)88011-2","journal-title":"Int Rev Neurobiol"},{"issue":"10","key":"1325_CR12","doi-asserted-by":"publisher","first-page":"e2414","DOI":"10.1038\/cddis.2016.319","volume":"7","author":"M Ka","year":"2016","unstructured":"Ka M, Kook YH, Liao K, Buch S, Kim WY (2016) Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons. Cell Death Dis 7(10):e2414. https:\/\/doi.org\/10.1038\/cddis.2016.319","journal-title":"Cell Death Dis"},{"issue":"8","key":"1325_CR13","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1080\/15548627.2016.1183844","volume":"12","author":"P Periyasamy","year":"2016","unstructured":"Periyasamy P, Guo ML, Buch S (2016) Cocaine induces astrocytosis through ER stress-mediated activation of autophagy. Autophagy 12(8):1310\u20131329. https:\/\/doi.org\/10.1080\/15548627.2016.1183844","journal-title":"Autophagy"},{"issue":"3","key":"1325_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.tips.2016.12.001","volume":"38","author":"J Rustenhoven","year":"2017","unstructured":"Rustenhoven J, Jansson D, Smyth LC, Dragunow M (2017) Brain pericytes as mediators of neuroinflammation. Trends Pharmacol Sci 38(3):291\u2013304. https:\/\/doi.org\/10.1016\/j.tips.2016.12.001","journal-title":"Trends Pharmacol Sci"},{"issue":"12","key":"1325_CR15","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1111\/j.1582-4934.2012.01622.x","volume":"16","author":"S Nakagawa","year":"2012","unstructured":"Nakagawa S, Castro V, Toborek M (2012) Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier. J Cell Mol Med 16(12):2950\u20132957. https:\/\/doi.org\/10.1111\/j.1582-4934.2012.01622.x","journal-title":"J Cell Mol Med"},{"key":"1325_CR16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainres.2018.04.023","volume":"1692","author":"J Matsumoto","year":"2018","unstructured":"Matsumoto J, Dohgu S, Takata F, Machida T, Bolukbasi Hatip FF, Hatip-Al-Khatib I, Yamauchi A, Kataoka Y (2018) TNF-alpha-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IkappaB-NFkappaB and JAK-STAT3 pathways. Brain Res 1692:34\u201344. https:\/\/doi.org\/10.1016\/j.brainres.2018.04.023","journal-title":"Brain Res"},{"key":"1325_CR17","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/cns.12821","volume":"24","author":"XG Liang","year":"2018","unstructured":"Liang XG, Tan C, Wang CK, Tao RR, Huang YJ, Ma KF, Fukunaga K, Huang MZ et al (2018) Myt1l induced direct reprogramming of pericytes into cholinergic neurons. CNS Neurosci Ther 24:801\u2013809. https:\/\/doi.org\/10.1111\/cns.12821","journal-title":"CNS Neurosci Ther"},{"issue":"6","key":"1325_CR18","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1177\/0271678X17740793","volume":"38","author":"WA Banks","year":"2018","unstructured":"Banks WA, Kovac A, Morofuji Y (2018) Neurovascular unit crosstalk: pericytes and astrocytes modify cytokine secretion patterns of brain endothelial cells. J Cereb Blood Flow Metab 38(6):1104\u20131118. https:\/\/doi.org\/10.1177\/0271678X17740793","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"1325_CR19","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nn.4288","volume":"19","author":"MD Sweeney","year":"2016","unstructured":"Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci 19(6):771\u2013783. https:\/\/doi.org\/10.1038\/nn.4288","journal-title":"Nat Neurosci"},{"issue":"6","key":"1325_CR20","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nm.4331","volume":"23","author":"Y Li","year":"2017","unstructured":"Li Y, Lucas-Osma AM, Black S, Bandet MV, Stephens MJ, Vavrek R, Sanelli L, Fenrich KK et al (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med 23(6):733\u2013741. https:\/\/doi.org\/10.1038\/nm.4331","journal-title":"Nat Med"},{"key":"1325_CR21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.2741\/4380","volume":"21","author":"L da Silva Meirelles","year":"2016","unstructured":"da Silva Meirelles L, Bellagamba BC, Camassola M, Nardi NB (2016) Mesenchymal stem cells and their relationship to pericytes. Front Biosci (Landmark Ed) 21:130\u2013156","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"3","key":"1325_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000362276","volume":"51","author":"PC Stapor","year":"2014","unstructured":"Stapor PC, Sweat RS, Dashti DC, Betancourt AM, Murfee WL (2014) Pericyte dynamics during angiogenesis: new insights from new identities. J Vasc Res 51(3):163\u2013174. https:\/\/doi.org\/10.1159\/000362276","journal-title":"J Vasc Res"},{"issue":"6","key":"1325_CR23","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1084\/jem.20111622","volume":"209","author":"D Proebstl","year":"2012","unstructured":"Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S (2012) Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med 209(6):1219\u20131234. https:\/\/doi.org\/10.1084\/jem.20111622","journal-title":"J Exp Med"},{"key":"1325_CR24","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3389\/fimmu.2016.00480","volume":"7","author":"R Navarro","year":"2016","unstructured":"Navarro R, Compte M, Alvarez-Vallina L, Sanz L (2016) Immune regulation by pericytes: modulating innate and adaptive immunity. Front Immunol 7:480. https:\/\/doi.org\/10.3389\/fimmu.2016.00480","journal-title":"Front Immunol"},{"issue":"2","key":"1325_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1177\/0271678X17720816","volume":"38","author":"V Castro","year":"2018","unstructured":"Castro V, Skowronska M, Lombardi J, He J, Seth N, Velichkovska M, Toborek M (2018) Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity. J Cereb Blood Flow Metab 38(2):317\u2013332. https:\/\/doi.org\/10.1177\/0271678X17720816","journal-title":"J Cereb Blood Flow Metab"},{"key":"1325_CR26","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3389\/fnmol.2017.00410","volume":"10","author":"HJ Cho","year":"2017","unstructured":"Cho HJ, Kuo AM, Bertrand L, Toborek M (2017) HIV alters gap junction-mediated intercellular communication in human brain Pericytes. Front Mol Neurosci 10:410. https:\/\/doi.org\/10.3389\/fnmol.2017.00410","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"1325_CR27","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1177\/0271678X15606149","volume":"36","author":"Y Persidsky","year":"2016","unstructured":"Persidsky Y, Hill J, Zhang M, Dykstra H, Winfield M, Reichenbach NL, Potula R, Mukherjee A et al (2016) Dysfunction of brain pericytes in chronic neuroinflammation. J Cereb Blood Flow Metab 36(4):794\u2013807. https:\/\/doi.org\/10.1177\/0271678X15606149","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"1325_CR28","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1124\/jpet.103.051292","volume":"306","author":"T Hayashi","year":"2003","unstructured":"Hayashi T, Su TP (2003) Intracellular dynamics of sigma-1 receptors (sigma(1) binding sites) in NG108-15 cells. J Pharmacol Exp Ther 306(2):726\u2013733. https:\/\/doi.org\/10.1124\/jpet.103.051292","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"1325_CR29","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/S0893-133X(01)00391-8","volume":"26","author":"P Romieu","year":"2002","unstructured":"Romieu P, Phan VL, Martin-Fardon R, Maurice T (2002) Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade. Neuropsychopharmacology 26(4):444\u2013455. https:\/\/doi.org\/10.1016\/S0893-133X(01)00391-8","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"1325_CR30","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0149-7634(02)00017-9","volume":"26","author":"T Maurice","year":"2002","unstructured":"Maurice T, Martin-Fardon R, Romieu P, Matsumoto RR (2002) Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neurosci Biobehav Rev 26(4):499\u2013527","journal-title":"Neurosci Biobehav Rev"},{"issue":"23","key":"1325_CR31","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1182\/blood-2010-01-266221","volume":"115","author":"H Yao","year":"2010","unstructured":"Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP et al (2010) Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood 115(23):4951\u20134962. https:\/\/doi.org\/10.1182\/blood-2010-01-266221","journal-title":"Blood"},{"issue":"4","key":"1325_CR32","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1586\/ecp.09.18","volume":"2","author":"RR Matsumoto","year":"2009","unstructured":"Matsumoto RR (2009) Targeting sigma receptors: novel medication development for drug abuse and addiction. Expert Rev Clin Pharmacol 2(4):351\u2013358. https:\/\/doi.org\/10.1586\/ecp.09.18","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"2","key":"1325_CR33","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","volume":"14","author":"L Yu","year":"2018","unstructured":"Yu L, Chen Y, Tooze SA (2018) Autophagy pathway: cellular and molecular mechanisms. Autophagy 14(2):207\u2013215. https:\/\/doi.org\/10.1080\/15548627.2017.1378838","journal-title":"Autophagy"},{"issue":"5","key":"1325_CR34","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1523\/JNEUROSCI.3207-14.2015","volume":"35","author":"J Fields","year":"2015","unstructured":"Fields J, Dumaop W, Eleuteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A et al (2015) HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci 35(5):1921\u20131938. https:\/\/doi.org\/10.1523\/JNEUROSCI.3207-14.2015","journal-title":"J Neurosci"},{"issue":"10","key":"1325_CR35","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.4161\/auto.29647","volume":"10","author":"MH Cho","year":"2014","unstructured":"Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, Kwon HJ, Kim HM, Kim DH et al (2014) Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 10(10):1761\u20131775. https:\/\/doi.org\/10.4161\/auto.29647","journal-title":"Autophagy"},{"issue":"2","key":"1325_CR36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/15548627.2015.1121360","volume":"12","author":"Y Cai","year":"2016","unstructured":"Cai Y, Arikkath J, Yang L, Guo ML, Periyasamy P, Buch S (2016) Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy 12(2):225\u2013244. https:\/\/doi.org\/10.1080\/15548627.2015.1121360","journal-title":"Autophagy"},{"issue":"4","key":"1325_CR37","doi-asserted-by":"publisher","first-page":"429","DOI":"10.4161\/auto.7.4.14393","volume":"7","author":"AR Winslow","year":"2011","unstructured":"Winslow AR, Rubinsztein DC (2011) The Parkinson disease protein alpha-synuclein inhibits autophagy. Autophagy 7(4):429\u2013431","journal-title":"Autophagy"},{"issue":"7","key":"1325_CR38","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1080\/15548627.2015.1052205","volume":"11","author":"ML Guo","year":"2015","unstructured":"Guo ML, Liao K, Periyasamy P, Yang L, Cai Y, Callen SE, Buch S (2015) Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Autophagy 11(7):995\u20131009. https:\/\/doi.org\/10.1080\/15548627.2015.1052205","journal-title":"Autophagy"},{"issue":"35","key":"1325_CR39","doi-asserted-by":"publisher","first-page":"11812","DOI":"10.1523\/JNEUROSCI.1139-14.2014","volume":"34","author":"F Niu","year":"2014","unstructured":"Niu F, Yao H, Zhang W, Sutliff RL, Buch S (2014) Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci 34(35):11812\u201311825. https:\/\/doi.org\/10.1523\/JNEUROSCI.1139-14.2014","journal-title":"J Neurosci"},{"key":"1325_CR40","doi-asserted-by":"publisher","first-page":"6713","DOI":"10.1007\/s12035-018-0878-2","volume":"55","author":"S Sil","year":"2018","unstructured":"Sil S, Periyasamy P, Guo ML, Callen S, Buch S (2018) Morphine-mediated brain region-specific astrocytosis involves the ER stress-autophagy axis. Mol Neurobiol 55:6713\u20136733. https:\/\/doi.org\/10.1007\/s12035-018-0878-2","journal-title":"Mol Neurobiol"},{"issue":"5","key":"1325_CR41","doi-asserted-by":"publisher","first-page":"452","DOI":"10.4161\/auto.4451","volume":"3","author":"S Kimura","year":"2007","unstructured":"Kimura S, Noda T, Yoshimori T (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3(5):452\u2013460","journal-title":"Autophagy"},{"issue":"5","key":"1325_CR42","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1520\/JFS14828J","volume":"45","author":"KS Kalasinsky","year":"2000","unstructured":"Kalasinsky KS, Bosy TZ, Schmunk GA, Ang L, Adams V, Gore SB, Smialek J, Furukawa Y et al (2000) Regional distribution of cocaine in postmortem brain of chronic human cocaine users. J Forensic Sci 45(5):1041\u20131048","journal-title":"J Forensic Sci"},{"issue":"4","key":"1325_CR43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.31887\/DCNS.2007.9.4\/pkalivas","volume":"9","author":"PW Kalivas","year":"2007","unstructured":"Kalivas PW (2007) Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity. Dialogues Clin Neurosci 9(4):389\u2013397","journal-title":"Dialogues Clin Neurosci"},{"issue":"12","key":"1325_CR44","first-page":"575","volume":"31","author":"A Prakash","year":"1993","unstructured":"Prakash A, Das G (1993) Cocaine and the nervous system. Int J Clin Pharmacol Ther Toxicol 31(12):575\u2013581","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"issue":"6","key":"1325_CR45","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1046\/j.1471-4159.1997.68062442.x","volume":"68","author":"MC Nassogne","year":"1997","unstructured":"Nassogne MC, Louahed J, Evrard P, Courtoy PJ (1997) Cocaine induces apoptosis in cortical neurons of fetal mice. J Neurochem 68(6):2442\u20132450","journal-title":"J Neurochem"},{"key":"1325_CR46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fphar.2012.00121","volume":"3","author":"SM Kousik","year":"2012","unstructured":"Kousik SM, Napier TC, Carvey PM (2012) The effects of psychostimulant drugs on blood brain barrier function and neuroinflammation. Front Pharmacol 3:121. https:\/\/doi.org\/10.3389\/fphar.2012.00121","journal-title":"Front Pharmacol"},{"issue":"6","key":"1325_CR47","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/13550280701528684","volume":"13","author":"NK Dhillon","year":"2007","unstructured":"Dhillon NK, Williams R, Peng F, Tsai YJ, Dhillon S, Nicolay B, Gadgil M, Kumar A et al (2007) Cocaine-mediated enhancement of virus replication in macrophages: implications for human immunodeficiency virus-associated dementia. J Neurovirol 13(6):483\u2013495. https:\/\/doi.org\/10.1080\/13550280701528684","journal-title":"J Neurovirol"},{"issue":"1","key":"1325_CR48","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neuint.2006.06.012","volume":"50","author":"HF Poon","year":"2007","unstructured":"Poon HF, Abdullah L, Mullan MA, Mullan MJ, Crawford FC (2007) Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells. Neurochem Int 50(1):69\u201373. https:\/\/doi.org\/10.1016\/j.neuint.2006.06.012","journal-title":"Neurochem Int"},{"issue":"7","key":"1325_CR49","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1007\/s12035-015-9377-x","volume":"53","author":"L Cao","year":"2016","unstructured":"Cao L, Walker MP, Vaidya NK, Fu M, Kumar S, Kumar A (2016) Cocaine-mediated autophagy in astrocytes involves sigma 1 receptor, PI3K, mTOR, Atg5\/7, Beclin-1 and induces type II programed cell death. Mol Neurobiol 53(7):4417\u20134430. https:\/\/doi.org\/10.1007\/s12035-015-9377-x","journal-title":"Mol Neurobiol"},{"issue":"2","key":"1325_CR50","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s12640-012-9334-7","volume":"23","author":"KH Clark","year":"2013","unstructured":"Clark KH, Wiley CA, Bradberry CW (2013) Psychostimulant abuse and neuroinflammation: emerging evidence of their interconnection. Neurotox Res 23(2):174\u2013188. https:\/\/doi.org\/10.1007\/s12640-012-9334-7","journal-title":"Neurotox Res"},{"issue":"7323","key":"1325_CR51","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nature09513","volume":"468","author":"R Daneman","year":"2010","unstructured":"Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468(7323):562\u2013566. https:\/\/doi.org\/10.1038\/nature09513","journal-title":"Nature"},{"issue":"7323","key":"1325_CR52","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature09522","volume":"468","author":"A Armulik","year":"2010","unstructured":"Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J et al (2010) Pericytes regulate the blood-brain barrier. Nature 468(7323):557\u2013561. https:\/\/doi.org\/10.1038\/nature09522","journal-title":"Nature"},{"issue":"4","key":"1325_CR53","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1215\/S1152851705000232","volume":"7","author":"G Bergers","year":"2005","unstructured":"Bergers G, Song S (2005) The role of pericytes in blood-vessel formation and maintenance. Neuro-Oncology 7(4):452\u2013464. https:\/\/doi.org\/10.1215\/S1152851705000232","journal-title":"Neuro-Oncology"},{"issue":"7219","key":"1325_CR54","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nature07383","volume":"456","author":"T Saitoh","year":"2008","unstructured":"Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T et al (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456(7219):264\u2013268. https:\/\/doi.org\/10.1038\/nature07383","journal-title":"Nature"},{"issue":"3","key":"1325_CR55","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/icb.2012.82","volume":"91","author":"SA Jones","year":"2013","unstructured":"Jones SA, Mills KH, Harris J (2013) Autophagy and inflammatory diseases. Immunol Cell Biol 91(3):250\u2013258. https:\/\/doi.org\/10.1038\/icb.2012.82","journal-title":"Immunol Cell Biol"},{"issue":"5","key":"1325_CR56","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1073\/pnas.1524860113","volume":"113","author":"P Guha","year":"2016","unstructured":"Guha P, Harraz MM, Snyder SH (2016) Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proc Natl Acad Sci U S A 113(5):1417\u20131422. https:\/\/doi.org\/10.1073\/pnas.1524860113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1325_CR57","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.tox.2013.07.016","volume":"312","author":"I Funakoshi-Hirose","year":"2013","unstructured":"Funakoshi-Hirose I, Aki T, Unuma K, Funakoshi T, Noritake K, Uemura K (2013) Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes. Toxicology 312:74\u201382. https:\/\/doi.org\/10.1016\/j.tox.2013.07.016","journal-title":"Toxicology"},{"issue":"2","key":"1325_CR58","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ceb.2011.01.003","volume":"23","author":"S Matus","year":"2011","unstructured":"Matus S, Glimcher LH, Hetz C (2011) Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr Opin Cell Biol 23(2):239\u2013252. https:\/\/doi.org\/10.1016\/j.ceb.2011.01.003","journal-title":"Curr Opin Cell Biol"},{"issue":"10","key":"1325_CR59","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1111\/j.1582-4934.2011.01374.x","volume":"15","author":"KM Doyle","year":"2011","unstructured":"Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med 15(10):2025\u20132039. https:\/\/doi.org\/10.1111\/j.1582-4934.2011.01374.x","journal-title":"J Cell Mol Med"},{"issue":"12","key":"1325_CR60","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1038\/onc.2012.174","volume":"32","author":"IA Ciechomska","year":"2013","unstructured":"Ciechomska IA, Gabrusiewicz K, Szczepankiewicz AA, Kaminska B (2013) Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine a-induced cell death. Oncogene 32(12):1518\u20131529. https:\/\/doi.org\/10.1038\/onc.2012.174","journal-title":"Oncogene"},{"issue":"5","key":"1325_CR61","doi-asserted-by":"publisher","first-page":"425","DOI":"10.2174\/157016212802138823","volume":"10","author":"S Buch","year":"2012","unstructured":"Buch S, Yao H, Guo M, Mori T, Mathias-Costa B, Singh V, Seth P, Wang J et al (2012) Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms. Curr HIV Res 10(5):425\u2013428","journal-title":"Curr HIV Res"},{"issue":"2","key":"1325_CR62","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1007\/s12035-015-9094-5","volume":"53","author":"L Yang","year":"2016","unstructured":"Yang L, Yao H, Chen X, Cai Y, Callen S, Buch S (2016) Role of sigma receptor in cocaine-mediated induction of glial fibrillary acidic protein: implications for HAND. Mol Neurobiol 53(2):1329\u20131342. https:\/\/doi.org\/10.1007\/s12035-015-9094-5","journal-title":"Mol Neurobiol"},{"key":"1325_CR63","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-3-319-50174-1_12","volume":"964","author":"Y Cai","year":"2017","unstructured":"Cai Y, Yang L, Niu F, Liao K, Buch S (2017) Role of Sigma-1 receptor in cocaine abuse and neurodegenerative disease. Adv Exp Med Biol 964:163\u2013175. https:\/\/doi.org\/10.1007\/978-3-319-50174-1_12","journal-title":"Adv Exp Med Biol"},{"issue":"47","key":"1325_CR64","doi-asserted-by":"publisher","first-page":"E6562","DOI":"10.1073\/pnas.1518894112","volume":"112","author":"SY Tsai","year":"2015","unstructured":"Tsai SY, Chuang JY, Tsai MS, Wang XF, Xi ZX, Hung JJ, Chang WC, Bonci A et al (2015) Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope. Proc Natl Acad Sci U S A 112(47):E6562\u2013E6570. https:\/\/doi.org\/10.1073\/pnas.1518894112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1325_CR65","doi-asserted-by":"publisher","first-page":"8670","DOI":"10.1038\/srep08670","volume":"5","author":"CC Nixon","year":"2015","unstructured":"Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN (2015) Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Sci Rep 5:8670. https:\/\/doi.org\/10.1038\/srep08670","journal-title":"Sci Rep"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1325-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1325-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1325-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T11:50:14Z","timestamp":1661860214000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1325-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1325"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1325-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,27]]},"assertion":[{"value":"14 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}