{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:48:25Z","timestamp":1772632105973,"version":"3.50.1"},"reference-count":110,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 509 TPA10; FA 159\/14-1"],"award-info":[{"award-number":["SFB 509 TPA10; FA 159\/14-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["GSC 98\/1, Research School, Ruhr-University Bochum"],"award-info":[{"award-number":["GSC 98\/1, Research School, Ruhr-University Bochum"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004079","name":"Konrad-Adenauer-Stiftung","doi-asserted-by":"publisher","award":["200520593"],"award-info":[{"award-number":["200520593"]}],"id":[{"id":"10.13039\/501100004079","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s12035-018-1376-2","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T16:32:32Z","timestamp":1539361952000},"page":"4322-4345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation and Progressive Glaucomatous Neurodegeneration"],"prefix":"10.1007","volume":"56","author":[{"given":"Jacqueline","family":"Reinhard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Wiemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie C.","family":"Joachim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Palmhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Woestmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Denecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory P.","family":"Downey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-8259","authenticated-orcid":false,"given":"Andreas","family":"Faissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"issue":"11","key":"1376_CR1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121(11):2081\u20132090. \n                    https:\/\/doi.org\/10.1016\/j.ophtha.2014.05.013","journal-title":"Ophthalmology"},{"key":"1376_CR2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev.neuro.051508.135728","volume":"35","author":"RW Nickells","year":"2012","unstructured":"Nickells RW, Howell GR, Soto I, John SW (2012) Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu Rev Neurosci 35:153\u2013179. \n                    https:\/\/doi.org\/10.1146\/annurev.neuro.051508.135728","journal-title":"Annu Rev Neurosci"},{"issue":"36","key":"1376_CR3","doi-asserted-by":"publisher","first-page":"13352","DOI":"10.1073\/pnas.0405479101","volume":"101","author":"MF Cordeiro","year":"2004","unstructured":"Cordeiro MF, Guo L, Luong V, Harding G, Wang W, Jones HE, Moss SE, Sillito AM et al (2004) Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration. Proc Natl Acad Sci U S A 101(36):13352\u201313356. \n                    https:\/\/doi.org\/10.1073\/pnas.0405479101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt B","key":"1376_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejpb.2015.04.029","volume":"95","author":"BM Braunger","year":"2015","unstructured":"Braunger BM, Fuchshofer R, Tamm ER (2015) The aqueous humor outflow pathways in glaucoma: a unifying concept of disease mechanisms and causative treatment. Eur J Pharm Biopharm 95(Pt B):173\u2013181. \n                    https:\/\/doi.org\/10.1016\/j.ejpb.2015.04.029","journal-title":"Eur J Pharm Biopharm"},{"issue":"5","key":"1376_CR5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/IJG.0b013e31818c6ef6","volume":"18","author":"EC Johnson","year":"2009","unstructured":"Johnson EC, Morrison JC (2009) Friend or foe? Resolving the impact of glial responses in glaucoma. J Glaucoma 18(5):341\u2013353. \n                    https:\/\/doi.org\/10.1097\/IJG.0b013e31818c6ef6","journal-title":"J Glaucoma"},{"issue":"3","key":"1376_CR6","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1167\/iovs.08-2717","volume":"50","author":"G Tezel","year":"2009","unstructured":"Tezel G (2009) The role of glia, mitochondria, and the immune system in glaucoma. Invest Ophthalmol Vis Sci 50(3):1001\u20131012. \n                    https:\/\/doi.org\/10.1167\/iovs.08-2717","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"1376_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.coph.2012.09.013","volume":"13","author":"G Tezel","year":"2013","unstructured":"Tezel G (2013) Immune regulation toward immunomodulation for neuroprotection in glaucoma. Curr Opin Pharmacol 13(1):23\u201331. \n                    https:\/\/doi.org\/10.1016\/j.coph.2012.09.013","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"1376_CR8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/00055735-200404000-00003","volume":"15","author":"G Tezel","year":"2004","unstructured":"Tezel G, Wax MB (2004) The immune system and glaucoma. Curr Opin Ophthalmol 15(2):80\u201384","journal-title":"Curr Opin Ophthalmol"},{"issue":"10","key":"1376_CR9","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1167\/iovs.10-5289","volume":"51","author":"G Tezel","year":"2010","unstructured":"Tezel G, Yang X, Luo C, Kain AD, Powell DW, Kuehn MH, Kaplan HJ (2010) Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci 51(10):5071\u20135082. \n                    https:\/\/doi.org\/10.1167\/iovs.10-5289","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1376_CR10","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0092-8674(00)81357-4","volume":"87","author":"NK Tonks","year":"1996","unstructured":"Tonks NK, Neel BG (1996) From form to function: signaling by protein tyrosine phosphatases. Cell 87(3):365\u2013368","journal-title":"Cell"},{"key":"1376_CR11","doi-asserted-by":"crossref","unstructured":"den Hertog J (1999) Protein-tyrosine phosphatases in development. Mech Dev 85 (1\u20132):3\u201314.","DOI":"10.1016\/S0925-4773(99)00089-1"},{"issue":"6","key":"1376_CR12","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.cell.2004.05.018","volume":"117","author":"A Alonso","year":"2004","unstructured":"Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J et al (2004) Protein tyrosine phosphatases in the human genome. Cell 117(6):699\u2013711. \n                    https:\/\/doi.org\/10.1016\/j.cell.2004.05.018","journal-title":"Cell"},{"issue":"2","key":"1376_CR13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ydbio.2017.03.023","volume":"428","author":"AJ Hale","year":"2017","unstructured":"Hale AJ, Ter Steege E, den Hertog J (2017) Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease. Dev Biol 428(2):283\u2013292. \n                    https:\/\/doi.org\/10.1016\/j.ydbio.2017.03.023","journal-title":"Dev Biol"},{"issue":"1","key":"1376_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrc2980","volume":"11","author":"SG Julien","year":"2011","unstructured":"Julien SG, Dube N, Hardy S, Tremblay ML (2011) Inside the human cancer tyrosine phosphatome. Nat Rev Cancer 11(1):35\u201349. \n                    https:\/\/doi.org\/10.1038\/nrc2980","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"1376_CR15","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nrm2039","volume":"7","author":"NK Tonks","year":"2006","unstructured":"Tonks NK (2006) Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol 7(11):833\u2013846. \n                    https:\/\/doi.org\/10.1038\/nrm2039","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1376_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nri1530","volume":"5","author":"T Mustelin","year":"2005","unstructured":"Mustelin T, Vang T, Bottini N (2005) Protein tyrosine phosphatases and the immune response. Nat Rev Immunol 5(1):43\u201357. \n                    https:\/\/doi.org\/10.1038\/nri1530","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"1376_CR17","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/s00018-003-3123-7","volume":"60","author":"S Paul","year":"2003","unstructured":"Paul S, Lombroso PJ (2003) Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci 60(11):2465\u20132482. \n                    https:\/\/doi.org\/10.1007\/s00018-003-3123-7","journal-title":"Cell Mol Life Sci"},{"key":"1376_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.semcdb.2014.09.006","volume":"37","author":"AW Stoker","year":"2015","unstructured":"Stoker AW (2015) RPTPs in axons, synapses and neurology. Semin Cell Dev Biol 37:90\u201397. \n                    https:\/\/doi.org\/10.1016\/j.semcdb.2014.09.006","journal-title":"Semin Cell Dev Biol"},{"issue":"3","key":"1376_CR19","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.neuroscience.2008.01.016","volume":"152","author":"A Horvat-Brocker","year":"2008","unstructured":"Horvat-Brocker A, Reinhard J, Illes S, Paech T, Zoidl G, Harroch S, Distler C, Knyazev P et al (2008) Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina. Neuroscience 152(3):618\u2013645. \n                    https:\/\/doi.org\/10.1016\/j.neuroscience.2008.01.016","journal-title":"Neuroscience"},{"issue":"3\u20134","key":"1376_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00221-009-1963-6","volume":"199","author":"J Reinhard","year":"2009","unstructured":"Reinhard J, Horvat-Brocker A, Illes S, Zaremba A, Knyazev P, Ullrich A, Faissner A (2009) Protein tyrosine phosphatases expression during development of mouse superior colliculus. Exp Brain Res 199(3\u20134):279\u2013297. \n                    https:\/\/doi.org\/10.1007\/s00221-009-1963-6","journal-title":"Exp Brain Res"},{"issue":"7","key":"1376_CR21","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1073\/pnas.89.7.2980","volume":"89","author":"M Gu","year":"1992","unstructured":"Gu M, Warshawsky I, Majerus PW (1992) Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. Proc Natl Acad Sci U S A 89(7):2980\u20132984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"1376_CR22","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1182\/blood-2010-08-302711","volume":"117","author":"X Huang","year":"2011","unstructured":"Huang X, Gschweng E, Van Handel B, Cheng D, Mikkola HK, Witte ON (2011) Regulated expression of microRNAs-126\/126* inhibits erythropoiesis from human embryonic stem cells. Blood 117(7):2157\u20132165. \n                    https:\/\/doi.org\/10.1182\/blood-2010-08-302711","journal-title":"Blood"},{"issue":"13","key":"1376_CR23","doi-asserted-by":"publisher","first-page":"4354","DOI":"10.1182\/blood-2003-04-1308","volume":"102","author":"MJ Xu","year":"2003","unstructured":"Xu MJ, Sui X, Zhao R, Dai C, Krantz SB, Zhao ZJ (2003) PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells. Blood 102(13):4354\u20134360. \n                    https:\/\/doi.org\/10.1182\/blood-2003-04-1308","journal-title":"Blood"},{"issue":"9","key":"1376_CR24","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/ncb1164","volume":"6","author":"H Huynh","year":"2004","unstructured":"Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E et al (2004) Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol 6(9):831\u2013839. \n                    https:\/\/doi.org\/10.1038\/ncb1164","journal-title":"Nat Cell Biol"},{"issue":"20","key":"1376_CR25","doi-asserted-by":"publisher","first-page":"15170","DOI":"10.1074\/jbc.M608682200","volume":"282","author":"K Saito","year":"2007","unstructured":"Saito K, Williams S, Bulankina A, Honing S, Mustelin T (2007) Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins. J Biol Chem 282(20):15170\u201315178. \n                    https:\/\/doi.org\/10.1074\/jbc.M608682200","journal-title":"J Biol Chem"},{"issue":"11","key":"1376_CR26","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1084\/jem.20051108","volume":"202","author":"Y Wang","year":"2005","unstructured":"Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P et al (2005) Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med 202(11):1587\u20131597. \n                    https:\/\/doi.org\/10.1084\/jem.20051108","journal-title":"J Exp Med"},{"issue":"12","key":"1376_CR27","doi-asserted-by":"publisher","first-page":"6661","DOI":"10.4049\/jimmunol.171.12.6661","volume":"171","author":"H Huynh","year":"2003","unstructured":"Huynh H, Wang X, Li W, Bottini N, Williams S, Nika K, Ishihara H, Godzik A et al (2003) Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. J Immunol 171(12):6661\u20136671","journal-title":"J Immunol"},{"issue":"Suppl 1","key":"1376_CR28","doi-asserted-by":"publisher","first-page":"11866","DOI":"10.1073\/pnas.1834200100","volume":"100","author":"KA D\u2019Amour","year":"2003","unstructured":"D\u2019Amour KA, Gage FH (2003) Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proc Natl Acad Sci U S A 100(Suppl 1):11866\u201311872. \n                    https:\/\/doi.org\/10.1073\/pnas.1834200100","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"46","key":"1376_CR29","doi-asserted-by":"publisher","first-page":"23895","DOI":"10.1074\/jbc.M116.728550","volume":"291","author":"D Zhang","year":"2016","unstructured":"Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G (2016) The protein tyrosine phosphatase MEG2 regulates the transport and signal transduction of tropomyosin receptor kinase a. J Biol Chem 291(46):23895\u201323905. \n                    https:\/\/doi.org\/10.1074\/jbc.M116.728550","journal-title":"J Biol Chem"},{"issue":"4","key":"1376_CR30","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2217\/17460875.3.4.399","volume":"3","author":"AJ Curwin","year":"2008","unstructured":"Curwin AJ, McMaster CR (2008) Structure and function of the enigmatic Sec14 domain-containing proteins and the etiology of human disease. Future Lipidol 3(4):399\u2013410. \n                    https:\/\/doi.org\/10.2217\/17460875.3.4.399","journal-title":"Future Lipidol"},{"key":"1376_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00140","volume":"10","author":"S Reinehr","year":"2016","unstructured":"Reinehr S, Reinhard J, Gandej M, Kuehn S, Noristani R, Faissner A, Dick HB, Joachim SC (2016) Simultaneous complement response via lectin pathway in retina and optic nerve in an experimental autoimmune glaucoma model. Front Cell Neurosci 10:140. \n                    https:\/\/doi.org\/10.3389\/fncel.2016.00140","journal-title":"Front Cell Neurosci"},{"key":"1376_CR32","doi-asserted-by":"publisher","first-page":"43470","DOI":"10.1038\/srep43470","volume":"7","author":"J Reinhard","year":"2017","unstructured":"Reinhard J, Renner M, Wiemann S, Shakoor DA, Stute G, Dick HB, Faissner A, Joachim SC (2017) Ischemic injury leads to extracellular matrix alterations in retina and optic nerve. Sci Rep 7:43470. \n                    https:\/\/doi.org\/10.1038\/srep43470","journal-title":"Sci Rep"},{"issue":"2","key":"1376_CR33","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00441-014-2050-2","volume":"359","author":"V Luft","year":"2015","unstructured":"Luft V, Reinhard J, Shibuya M, Fischer KD, Faissner A (2015) The guanine nucleotide exchange factor Vav3 regulates differentiation of progenitor cells in the developing mouse retina. Cell Tissue Res 359(2):423\u2013440. \n                    https:\/\/doi.org\/10.1007\/s00441-014-2050-2","journal-title":"Cell Tissue Res"},{"issue":"9","key":"1376_CR34","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","volume":"30","author":"MW Pfaffl","year":"2002","unstructured":"Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30(9):e36","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"1376_CR35","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L et al (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5(10):R80. \n                    https:\/\/doi.org\/10.1186\/gb-2004-5-10-r80","journal-title":"Genome Biol"},{"issue":"2","key":"1376_CR36","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4(2):249\u2013264. \n                    https:\/\/doi.org\/10.1093\/biostatistics\/4.2.249","journal-title":"Biostatistics"},{"issue":"4","key":"1376_CR37","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1167\/iovs.13-13372","volume":"55","author":"H Schmid","year":"2014","unstructured":"Schmid H, Renner M, Dick HB, Joachim SC (2014) Loss of inner retinal neurons after retinal ischemia in rats. Invest Ophthalmol Vis Sci 55(4):2777\u20132787. \n                    https:\/\/doi.org\/10.1167\/iovs.13-13372","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"1376_CR38","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1111\/jcmm.12909","volume":"20","author":"S Reinehr","year":"2016","unstructured":"Reinehr S, Reinhard J, Wiemann S, Stute G, Kuehn S, Woestmann J, Dick HB, Faissner A et al (2016) Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model. J Cell Mol Med 20(11):2122\u20132137. \n                    https:\/\/doi.org\/10.1111\/jcmm.12909","journal-title":"J Cell Mol Med"},{"issue":"2","key":"1376_CR39","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","volume":"31","author":"M Almasieh","year":"2012","unstructured":"Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31(2):152\u2013181. \n                    https:\/\/doi.org\/10.1016\/j.preteyeres.2011.11.002","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"1376_CR40","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1167\/iovs.08-3267","volume":"50","author":"FM Nadal-Nicolas","year":"2009","unstructured":"Nadal-Nicolas FM, Jimenez-Lopez M, Sobrado-Calvo P, Nieto-Lopez L, Canovas-Martinez I, Salinas-Navarro M, Vidal-Sanz M, Agudo M (2009) Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. Invest Ophthalmol Vis Sci 50(8):3860\u20133868. \n                    https:\/\/doi.org\/10.1167\/iovs.08-3267","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"1376_CR41","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1073\/pnas.93.2.596","volume":"93","author":"M Xiang","year":"1996","unstructured":"Xiang M, Zhou H, Nathans J (1996) Molecular biology of retinal ganglion cells. Proc Natl Acad Sci U S A 93(2):596\u2013601","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"1376_CR42","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/glia.20516","volume":"55","author":"DM Inman","year":"2007","unstructured":"Inman DM, Horner PJ (2007) Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia 55(9):942\u2013953. \n                    https:\/\/doi.org\/10.1002\/glia.20516","journal-title":"Glia"},{"key":"1376_CR43","doi-asserted-by":"publisher","first-page":"2954721","DOI":"10.1155\/2016\/2954721","volume":"2016","author":"R Hoz de","year":"2016","unstructured":"de Hoz R, Rojas B, Ramirez AI, Salazar JJ, Gallego BI, Trivino A, Ramirez JM (2016) Retinal macroglial responses in health and disease. Biomed Res Int 2016:2954721. \n                    https:\/\/doi.org\/10.1155\/2016\/2954721","journal-title":"Biomed Res Int"},{"issue":"1","key":"1376_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000328979","volume":"227","author":"A Bringmann","year":"2012","unstructured":"Bringmann A, Wiedemann P (2012) Muller glial cells in retinal disease. Ophthalmologica 227(1):1\u201319. \n                    https:\/\/doi.org\/10.1159\/000328979","journal-title":"Ophthalmologica"},{"issue":"9\u201310","key":"1376_CR45","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.imbio.2010.05.010","volume":"215","author":"M Karlstetter","year":"2010","unstructured":"Karlstetter M, Ebert S, Langmann T (2010) Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology 215(9\u201310):685\u2013691. \n                    https:\/\/doi.org\/10.1016\/j.imbio.2010.05.010","journal-title":"Immunobiology"},{"issue":"6","key":"1376_CR46","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1189\/jlb.0207114","volume":"81","author":"T Langmann","year":"2007","unstructured":"Langmann T (2007) Microglia activation in retinal degeneration. J Leukoc Biol 81(6):1345\u20131351. \n                    https:\/\/doi.org\/10.1189\/jlb.0207114","journal-title":"J Leukoc Biol"},{"key":"1376_CR47","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","volume":"45","author":"M Karlstetter","year":"2015","unstructured":"Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, Langmann T (2015) Retinal microglia: just bystander or target for therapy? Prog Retin Eye Res 45:30\u201357. \n                    https:\/\/doi.org\/10.1016\/j.preteyeres.2014.11.004","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"1376_CR48","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1167\/iovs.03-1123","volume":"45","author":"F Ahmed","year":"2004","unstructured":"Ahmed F, Brown KM, Stephan DA, Morrison JC, Johnson EC, Tomarev SI (2004) Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. Invest Ophthalmol Vis Sci 45(4):1247\u20131258","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1376_CR49","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.exer.2006.03.002","volume":"83","author":"MH Kuehn","year":"2006","unstructured":"Kuehn MH, Kim CY, Ostojic J, Bellin M, Alward WL, Stone EM, Sakaguchi DS, Grozdanic SD et al (2006) Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp Eye Res 83(3):620\u2013628. \n                    https:\/\/doi.org\/10.1016\/j.exer.2006.03.002","journal-title":"Exp Eye Res"},{"issue":"2","key":"1376_CR50","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.exer.2008.04.012","volume":"87","author":"MH Kuehn","year":"2008","unstructured":"Kuehn MH, Kim CY, Jiang B, Dumitrescu AV, Kwon YH (2008) Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Exp Eye Res 87(2):89\u201395. \n                    https:\/\/doi.org\/10.1016\/j.exer.2008.04.012","journal-title":"Exp Eye Res"},{"issue":"3","key":"1376_CR51","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1167\/iovs.05-0830","volume":"47","author":"K Stasi","year":"2006","unstructured":"Stasi K, Nagel D, Yang X, Wang RF, Ren L, Podos SM, Mittag T, Danias J (2006) Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. Invest Ophthalmol Vis Sci 47(3):1024\u20131029. \n                    https:\/\/doi.org\/10.1167\/iovs.05-0830","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1376_CR52","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/978-1-4419-5635-4_7","volume":"703","author":"L Ren","year":"2010","unstructured":"Ren L, Danias J (2010) A role for complement in glaucoma? Adv Exp Med Biol 703:95\u2013104. \n                    https:\/\/doi.org\/10.1007\/978-1-4419-5635-4_7","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"1376_CR53","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1172\/JCI44646","volume":"121","author":"GR Howell","year":"2011","unstructured":"Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL et al (2011) Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest 121(4):1429\u20131444. \n                    https:\/\/doi.org\/10.1172\/JCI44646","journal-title":"J Clin Invest"},{"issue":"15\u201316","key":"1376_CR54","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/j.molimm.2011.07.012","volume":"48","author":"P Jha","year":"2011","unstructured":"Jha P, Banda H, Tytarenko R, Bora PS, Bora NS (2011) Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma. Mol Immunol 48(15\u201316):2151\u20132158. \n                    https:\/\/doi.org\/10.1016\/j.molimm.2011.07.012","journal-title":"Mol Immunol"},{"key":"1376_CR55","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1742-2094-10-76","volume":"10","author":"GR Howell","year":"2013","unstructured":"Howell GR, Soto I, Ryan M, Graham LC, Smith RS, John SW (2013) Deficiency of complement component 5 ameliorates glaucoma in DBA\/2J mice. J Neuroinflammation 10:76. \n                    https:\/\/doi.org\/10.1186\/1742-2094-10-76","journal-title":"J Neuroinflammation"},{"issue":"6","key":"1376_CR56","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/00061198-199912000-00011","volume":"8","author":"SW John","year":"1999","unstructured":"John SW, Anderson MG, Smith RS (1999) Mouse genetics: a tool to help unlock the mechanisms of glaucoma. J Glaucoma 8(6):400\u2013412","journal-title":"J Glaucoma"},{"issue":"4","key":"1376_CR57","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/01.ijg.0000169395.47921.02","volume":"14","author":"RN Weinreb","year":"2005","unstructured":"Weinreb RN, Lindsey JD (2005) The importance of models in glaucoma research. J Glaucoma 14(4):302\u2013304","journal-title":"J Glaucoma"},{"issue":"4","key":"1376_CR58","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.exer.2008.12.002","volume":"88","author":"SJ McKinnon","year":"2009","unstructured":"McKinnon SJ, Schlamp CL, Nickells RW (2009) Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res 88(4):816\u2013824. \n                    https:\/\/doi.org\/10.1016\/j.exer.2008.12.002","journal-title":"Exp Eye Res"},{"issue":"5","key":"1376_CR59","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/IJG.0b013e3181405d4f","volume":"16","author":"IH Pang","year":"2007","unstructured":"Pang IH, Clark AF (2007) Rodent models for glaucoma retinopathy and optic neuropathy. J Glaucoma 16(5):483\u2013505. \n                    https:\/\/doi.org\/10.1097\/IJG.0b013e3181405d4f","journal-title":"J Glaucoma"},{"issue":"4","key":"1376_CR60","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/gim.2014.95","volume":"17","author":"K Schil Van","year":"2015","unstructured":"Van Schil K, Meire F, Karlstetter M, Bauwens M, Verdin H, Coppieters F, Scheiffert E, Van Nechel C et al (2015) Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion. Genet Med 17(4):291\u2013299. \n                    https:\/\/doi.org\/10.1038\/gim.2014.95","journal-title":"Genet Med"},{"issue":"6","key":"1376_CR61","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/OPX.0b013e31817841e5","volume":"85","author":"W Cheung","year":"2008","unstructured":"Cheung W, Guo L, Cordeiro MF (2008) Neuroprotection in glaucoma: drug-based approaches. Optom Vis Sci 85(6):406\u2013416. \n                    https:\/\/doi.org\/10.1097\/OPX.0b013e31817841e5","journal-title":"Optom Vis Sci"},{"issue":"24","key":"1376_CR62","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1016\/S0042-6989(97)00047-3","volume":"37","author":"NJ Sucher","year":"1997","unstructured":"Sucher NJ, Lipton SA, Dreyer EB (1997) Molecular basis of glutamate toxicity in retinal ganglion cells. Vis Res 37(24):3483\u20133493. \n                    https:\/\/doi.org\/10.1016\/S0042-6989(97)00047-3","journal-title":"Vis Res"},{"issue":"5","key":"1376_CR63","doi-asserted-by":"publisher","first-page":"e0126859","DOI":"10.1371\/journal.pone.0126859","volume":"10","author":"C Ehlken","year":"2015","unstructured":"Ehlken C, Grundel B, Michels D, Junker B, Stahl A, Schlunck G, Hansen LL, Feltgen N et al (2015) Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion. PLoS One 10(5):e0126859. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0126859","journal-title":"PLoS One"},{"key":"1376_CR64","first-page":"796","volume":"19","author":"Q Zhang","year":"2013","unstructured":"Zhang Q, Jiang Y, Toutounchian JJ, Soderland C, Yates CR, Steinle JJ (2013) Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions. Mol Vis 19:796\u2013803","journal-title":"Mol Vis"},{"issue":"4","key":"1376_CR65","doi-asserted-by":"publisher","first-page":"e93788","DOI":"10.1371\/journal.pone.0093788","volume":"9","author":"Y Jiang","year":"2014","unstructured":"Jiang Y, Zhang Q, Steinle JJ (2014) Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina. PLoS One 9(4):e93788. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0093788","journal-title":"PLoS One"},{"issue":"2","key":"1376_CR66","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.cyto.2014.07.004","volume":"70","author":"Y Jiang","year":"2014","unstructured":"Jiang Y, Pagadala J, Miller DD, Steinle JJ (2014) Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina. Cytokine 70(2):115\u2013119. \n                    https:\/\/doi.org\/10.1016\/j.cyto.2014.07.004","journal-title":"Cytokine"},{"issue":"6","key":"1376_CR67","doi-asserted-by":"publisher","first-page":"e65267","DOI":"10.1371\/journal.pone.0065267","volume":"8","author":"S Richter","year":"2013","unstructured":"Richter S, Morrison S, Connor T, Su J, Print CG, Ronimus RS, McGee SL, Wilson WR (2013) Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism. PLoS One 8(6):e65267. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0065267","journal-title":"PLoS One"},{"issue":"5","key":"1376_CR68","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.celrep.2012.10.009","volume":"2","author":"MM Kaminski","year":"2012","unstructured":"Kaminski MM, Sauer SW, Kaminski M, Opp S, Ruppert T, Grigaravicius P, Grudnik P, Grone HJ et al (2012) T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. Cell Rep 2(5):1300\u20131315. \n                    https:\/\/doi.org\/10.1016\/j.celrep.2012.10.009","journal-title":"Cell Rep"},{"key":"1376_CR69","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12974-015-0360-2","volume":"12","author":"W Chi","year":"2015","unstructured":"Chi W, Chen H, Li F, Zhu Y, Yin W, Zhuo Y (2015) HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-kappaB pathway in acute glaucoma. J Neuroinflammation 12:137. \n                    https:\/\/doi.org\/10.1186\/s12974-015-0360-2","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1376_CR70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1292\/jvms.10-0201","volume":"73","author":"SA Ali","year":"2011","unstructured":"Ali SA, Hosaka YZ, Uehara M (2011) Spatiotemporal distribution of chondroitin sulfate proteoglycans in the developing mouse retina and optic nerve. J Vet Med Sci 73(1):13\u201318","journal-title":"J Vet Med Sci"},{"issue":"12","key":"1376_CR71","doi-asserted-by":"publisher","first-page":"7528","DOI":"10.1167\/iovs.12-10797","volume":"53","author":"TD Keenan","year":"2012","unstructured":"Keenan TD, Clark SJ, Unwin RD, Ridge LA, Day AJ, Bishop PN (2012) Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera. Invest Ophthalmol Vis Sci 53(12):7528\u20137538. \n                    https:\/\/doi.org\/10.1167\/iovs.12-10797","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1376_CR72","first-page":"798","volume":"11","author":"RP Kirwan","year":"2005","unstructured":"Kirwan RP, Fenerty CH, Crean J, Wordinger RJ, Clark AF, O\u2019Brien CJ (2005) Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro. Mol Vis 11:798\u2013810","journal-title":"Mol Vis"},{"issue":"4","key":"1376_CR73","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/glia.20247","volume":"52","author":"RP Kirwan","year":"2005","unstructured":"Kirwan RP, Leonard MO, Murphy M, Clark AF, O\u2019Brien CJ (2005) Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells. Glia 52(4):309\u2013324. \n                    https:\/\/doi.org\/10.1002\/glia.20247","journal-title":"Glia"},{"issue":"6","key":"1376_CR74","first-page":"951","volume":"39","author":"SW John","year":"1998","unstructured":"John SW, Smith RS, Savinova OV, Hawes NL, Chang B, Turnbull D, Davisson M, Roderick TH et al (1998) Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice. Invest Ophthalmol Vis Sci 39(6):951\u2013962","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"1376_CR75","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1017\/S0952523805225130","volume":"22","author":"RT Libby","year":"2005","unstructured":"Libby RT, Anderson MG, Pang IH, Robinson ZH, Savinova OV, Cosma IM, Snow A, Wilson LA et al (2005) Inherited glaucoma in DBA\/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci 22(5):637\u2013648. \n                    https:\/\/doi.org\/10.1017\/S0952523805225130","journal-title":"Vis Neurosci"},{"issue":"10","key":"1376_CR76","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.1167\/iovs.07-0582","volume":"48","author":"M Nagaraju","year":"2007","unstructured":"Nagaraju M, Saleh M, Porciatti V (2007) IOP-dependent retinal ganglion cell dysfunction in glaucomatous DBA\/2J mice. Invest Ophthalmol Vis Sci 48(10):4573\u20134579. \n                    https:\/\/doi.org\/10.1167\/iovs.07-0582","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1\u20132","key":"1376_CR77","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/S0006-8993(97)01189-X","volume":"784","author":"S Laquis","year":"1998","unstructured":"Laquis S, Chaudhary P, Sharma SC (1998) The patterns of retinal ganglion cell death in hypertensive eyes. Brain Res 784(1\u20132):100\u2013104","journal-title":"Brain Res"},{"issue":"2","key":"1376_CR78","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.exer.2006.01.025","volume":"83","author":"JH Urcola","year":"2006","unstructured":"Urcola JH, Hernandez M, Vecino E (2006) Three experimental glaucoma models in rats: comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death. Exp Eye Res 83(2):429\u2013437. \n                    https:\/\/doi.org\/10.1016\/j.exer.2006.01.025","journal-title":"Exp Eye Res"},{"issue":"1","key":"1376_CR79","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1167\/iovs.09-5115","volume":"52","author":"H Chen","year":"2011","unstructured":"Chen H, Wei X, Cho KS, Chen G, Sappington R, Calkins DJ, Chen DF (2011) Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. Invest Ophthalmol Vis Sci 52(1):36\u201344. \n                    https:\/\/doi.org\/10.1167\/iovs.09-5115","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1376_CR80","first-page":"913","volume":"28","author":"HA Quigley","year":"1987","unstructured":"Quigley HA, Sanchez RM, Dunkelberger GR, L\u2019Hernault NL, Baginski TA (1987) Chronic glaucoma selectively damages large optic nerve fibers. Invest Ophthalmol Vis Sci 28(6):913\u2013920","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1376_CR81","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1167\/iovs.08-2517","volume":"50","author":"J Battista","year":"2009","unstructured":"Battista J, Badcock DR, McKendrick AM (2009) Spatial summation properties for magnocellular and parvocellular pathways in glaucoma. Invest Ophthalmol Vis Sci 50(3):1221\u20131226. \n                    https:\/\/doi.org\/10.1167\/iovs.08-2517","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"1376_CR82","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1350-9462(03)00026-0","volume":"22","author":"YH Yucel","year":"2003","unstructured":"Yucel YH, Zhang Q, Weinreb RN, Kaufman PL, Gupta N (2003) Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res 22(4):465\u2013481","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"1376_CR83","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1083\/jcb.200506099","volume":"171","author":"TC Jakobs","year":"2005","unstructured":"Jakobs TC, Libby RT, Ben Y, John SW, Masland RH (2005) Retinal ganglion cell degeneration is topological but not cell type specific in DBA\/2J mice. J Cell Biol 171(2):313\u2013325. \n                    https:\/\/doi.org\/10.1083\/jcb.200506099","journal-title":"J Cell Biol"},{"issue":"22","key":"1376_CR84","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1523\/JNEUROSCI.16-22-07193.1996","volume":"16","author":"RW Williams","year":"1996","unstructured":"Williams RW, Strom RC, Rice DS, Goldowitz D (1996) Genetic and environmental control of variation in retinal ganglion cell number in mice. J Neurosci 16(22):7193\u20137205","journal-title":"J Neurosci"},{"issue":"1","key":"1376_CR85","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","volume":"18","author":"HA Quigley","year":"1999","unstructured":"Quigley HA (1999) Neuronal death in glaucoma. Prog Retin Eye Res 18(1):39\u201357","journal-title":"Prog Retin Eye Res"},{"issue":"46","key":"1376_CR86","doi-asserted-by":"publisher","first-page":"11903","DOI":"10.1523\/JNEUROSCI.3020-06.2006","volume":"26","author":"V Senatorov","year":"2006","unstructured":"Senatorov V, Malyukova I, Fariss R, Wawrousek EF, Swaminathan S, Sharan SK, Tomarev S (2006) Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice. J Neurosci 26(46):11903\u201311914. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.3020-06.2006","journal-title":"J Neurosci"},{"issue":"4","key":"1376_CR87","first-page":"995","volume":"7","author":"M Rogalinska","year":"2002","unstructured":"Rogalinska M (2002) Alterations in cell nuclei during apoptosis. Cell Mol Biol Lett 7(4):995\u20131018","journal-title":"Cell Mol Biol Lett"},{"issue":"5","key":"1376_CR88","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1167\/iovs.12-9483h","volume":"53","author":"RW Nickells","year":"2012","unstructured":"Nickells RW (2012) The cell and molecular biology of glaucoma: mechanisms of retinal ganglion cell death. Invest Ophthalmol Vis Sci 53(5):2476\u20132481. \n                    https:\/\/doi.org\/10.1167\/iovs.12-9483h","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1376_CR89","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1136\/bjo.84.3.303","volume":"84","author":"JE Morgan","year":"2000","unstructured":"Morgan JE, Uchida H, Caprioli J (2000) Retinal ganglion cell death in experimental glaucoma. Br J Ophthalmol 84(3):303\u2013310","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"1376_CR90","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/00061198-200208000-00015","volume":"11","author":"JE Morgan","year":"2002","unstructured":"Morgan JE (2002) Retinal ganglion cell shrinkage in glaucoma. J Glaucoma 11(4):365\u2013370","journal-title":"J Glaucoma"},{"issue":"12","key":"1376_CR91","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.1167\/iovs.02-1101","volume":"44","author":"J Danias","year":"2003","unstructured":"Danias J, Lee KC, Zamora MF, Chen B, Shen F, Filippopoulos T, Su Y, Goldblum D et al (2003) Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA\/2NNia glaucomatous mice: comparison with RGC loss in aging C57\/BL6 mice. Invest Ophthalmol Vis Sci 44(12):5151\u20135162","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1376_CR92","first-page":"1272","volume":"12","author":"HR Pelzel","year":"2006","unstructured":"Pelzel HR, Schlamp CL, Poulsen GL, Ver Hoeve JA, Nork TM, Nickells RW (2006) Decrease of cone opsin mRNA in experimental ocular hypertension. Mol Vis 12:1272\u20131282","journal-title":"Mol Vis"},{"issue":"4","key":"1376_CR93","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/bjo.85.4.397","volume":"85","author":"IM Velten","year":"2001","unstructured":"Velten IM, Korth M, Horn FK (2001) The a-wave of the dark adapted electroretinogram in glaucomas: are photoreceptors affected? Br J Ophthalmol 85(4):397\u2013402","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"1376_CR94","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.exer.2010.09.001","volume":"91","author":"P Heiduschka","year":"2010","unstructured":"Heiduschka P, Julien S, Schuettauf F, Schnichels S (2010) Loss of retinal function in aged DBA\/2J mice\u2014new insights into retinal neurodegeneration. Exp Eye Res 91(5):779\u2013783. \n                    https:\/\/doi.org\/10.1016\/j.exer.2010.09.001","journal-title":"Exp Eye Res"},{"issue":"9","key":"1376_CR95","doi-asserted-by":"publisher","first-page":"6059","DOI":"10.1167\/iovs.14-14421","volume":"55","author":"L Fernandez-Sanchez","year":"2014","unstructured":"Fernandez-Sanchez L, de Sevilla Muller LP, Brecha NC, Cuenca N (2014) Loss of outer retinal neurons and circuitry alterations in the DBA\/2J mouse. Invest Ophthalmol Vis Sci 55(9):6059\u20136072. \n                    https:\/\/doi.org\/10.1167\/iovs.14-14421","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"1376_CR96","first-page":"431","volume":"41","author":"EC Johnson","year":"2000","unstructured":"Johnson EC, Deppmeier LM, Wentzien SK, Hsu I, Morrison JC (2000) Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest Ophthalmol Vis Sci 41(2):431\u2013442","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"1376_CR97","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/glia.20000","volume":"47","author":"E Woldemussie","year":"2004","unstructured":"Woldemussie E, Wijono M, Ruiz G (2004) Muller cell response to laser-induced increase in intraocular pressure in rats. Glia 47(2):109\u2013119. \n                    https:\/\/doi.org\/10.1002\/glia.20000","journal-title":"Glia"},{"issue":"1","key":"1376_CR98","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.exer.2005.01.012","volume":"81","author":"A Kanamori","year":"2005","unstructured":"Kanamori A, Nakamura M, Nakanishi Y, Yamada Y, Negi A (2005) Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucoma. Exp Eye Res 81(1):48\u201356. \n                    https:\/\/doi.org\/10.1016\/j.exer.2005.01.012","journal-title":"Exp Eye Res"},{"issue":"7","key":"1376_CR99","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/glia.20962","volume":"58","author":"JL Son","year":"2010","unstructured":"Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N (2010) Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia 58(7):780\u2013789. \n                    https:\/\/doi.org\/10.1002\/glia.20962","journal-title":"Glia"},{"issue":"1\u20132","key":"1376_CR100","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0162-3109(00)80301-X","volume":"49","author":"U Kishore","year":"2000","unstructured":"Kishore U, Reid KB (2000) C1q: structure, function, and receptors. Immunopharmacology 49(1\u20132):159\u2013170","journal-title":"Immunopharmacology"},{"issue":"1","key":"1376_CR101","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12974-017-0814-9","volume":"14","author":"MI Fonseca","year":"2017","unstructured":"Fonseca MI, Chu SH, Hernandez MX, Fang MJ, Modarresi L, Selvan P, MacGregor GR, Tenner AJ (2017) Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. J Neuroinflammation 14(1):48. \n                    https:\/\/doi.org\/10.1186\/s12974-017-0814-9","journal-title":"J Neuroinflammation"},{"issue":"6","key":"1376_CR102","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","volume":"131","author":"B Stevens","year":"2007","unstructured":"Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK et al (2007) The classical complement cascade mediates CNS synapse elimination. Cell 131(6):1164\u20131178. \n                    https:\/\/doi.org\/10.1016\/j.cell.2007.10.036","journal-title":"Cell"},{"key":"1376_CR103","first-page":"1588","volume":"17","author":"C Luo","year":"2011","unstructured":"Luo C, Chen M, Xu H (2011) Complement gene expression and regulation in mouse retina and retinal pigment epithelium\/choroid. Mol Vis 17:1588\u20131597","journal-title":"Mol Vis"},{"issue":"7638","key":"1376_CR104","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Munch AE et al (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638):481\u2013487. \n                    https:\/\/doi.org\/10.1038\/nature21029","journal-title":"Nature"},{"issue":"11","key":"1376_CR105","doi-asserted-by":"publisher","first-page":"e0142199","DOI":"10.1371\/journal.pone.0142199","volume":"10","author":"R Kumari","year":"2015","unstructured":"Kumari R, Astafurov K, Genis A, Danias J (2015) Differential effects of C1qa ablation on glaucomatous damage in two sexes in DBA\/2NNia mice. PLoS One 10(11):e0142199. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0142199","journal-title":"PLoS One"},{"issue":"19","key":"1376_CR106","doi-asserted-by":"publisher","first-page":"E3839","DOI":"10.1073\/pnas.1608769114","volume":"114","author":"JM Harder","year":"2017","unstructured":"Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS et al (2017) Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A 114(19):E3839\u2013E3848. \n                    https:\/\/doi.org\/10.1073\/pnas.1608769114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1376_CR107","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13024-016-0089-0","volume":"11","author":"SM Silverman","year":"2016","unstructured":"Silverman SM, Kim BJ, Howell GR, Miller J, John SW, Wordinger RJ, Clark AF (2016) C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia\/reperfusion injury. Mol Neurodegener 11:24. \n                    https:\/\/doi.org\/10.1186\/s13024-016-0089-0","journal-title":"Mol Neurodegener"},{"key":"1376_CR108","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13024-016-0091-6","volume":"11","author":"PA Williams","year":"2016","unstructured":"Williams PA, Tribble JR, Pepper KW, Cross SD, Morgan BP, Morgan JE, John SW, Howell GR (2016) Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma. Mol Neurodegener 11:26. \n                    https:\/\/doi.org\/10.1186\/s13024-016-0091-6","journal-title":"Mol Neurodegener"},{"issue":"20","key":"1376_CR109","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1016\/S0042-6989(02)00188-8","volume":"42","author":"F Schuettauf","year":"2002","unstructured":"Schuettauf F, Quinto K, Naskar R, Zurakowski D (2002) Effects of anti-glaucoma medications on ganglion cell survival: the DBA\/2J mouse model. Vis Res 42(20):2333\u20132337","journal-title":"Vis Res"},{"issue":"2","key":"1376_CR110","doi-asserted-by":"publisher","first-page":"e9050","DOI":"10.1371\/journal.pone.0009050","volume":"5","author":"K Fujikawa","year":"2010","unstructured":"Fujikawa K, Iwata T, Inoue K, Akahori M, Kadotani H, Fukaya M, Watanabe M, Chang Q et al (2010) VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans. PLoS One 5(2):e9050. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0009050","journal-title":"PLoS One"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1376-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1376-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1376-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T19:26:14Z","timestamp":1570821974000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1376-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,12]]},"references-count":110,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["1376"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1376-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,12]]},"assertion":[{"value":"15 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All animal experiments were conducted in compliance with the \u201cAssociation for Research and Vision and Ophthalmology\u201d statement for the use of animals in ophthalmic and vision research and were approved by the ethics committee for animal experiments by the state North-Rhine Westphalia, Germany. The study was supervised by the animal welfare commissioner of the Ruhr-University Bochum. All efforts were made to reduce the number of animals in the experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}