{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:44:09Z","timestamp":1791384249494,"version":"4.3.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s12035-018-1379-z","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T16:55:29Z","timestamp":1539708929000},"page":"4414-4427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice"],"prefix":"10.1007","volume":"56","author":[{"given":"Sandra","family":"de la Fuente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Sansa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambika","family":"Periyakaruppiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garcera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-3102","authenticated-orcid":false,"given":"Rosa M.","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"1379_CR1","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1016\/S0140-6736(08)60921-6","volume":"371","author":"MR Lunn","year":"2008","unstructured":"Lunn MR, Wang CH (2008) Spinal muscular atrophy. Lancet 371:2120\u20132133","journal-title":"Lancet"},{"key":"1379_CR2","doi-asserted-by":"publisher","first-page":"8691","DOI":"10.1523\/JNEUROSCI.0417-15.2015","volume":"35","author":"S Tisdale","year":"2015","unstructured":"Tisdale S, Pellizzoni L (2015) Disease mechanisms and therapeutic approaches in spinal muscular atrophy. J Neurosci 35:8691\u20138700","journal-title":"J Neurosci"},{"key":"1379_CR3","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.nurx.2006.01.010","volume":"3","author":"CJ Sumner","year":"2006","unstructured":"Sumner CJ (2006) Therapeutics development for spinal muscular atrophy. NeuroRx 3:235\u2013245","journal-title":"NeuroRx"},{"key":"1379_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/nbdi.1996.0010","volume":"3","author":"TO Crawford","year":"1996","unstructured":"Crawford TO, Pardo CA (1996) The neurobiology of childhood spinal muscular atrophy. Neurobiol Dis 3:97\u2013110","journal-title":"Neurobiol Dis"},{"key":"1379_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","volume":"80","author":"S Lefebvre","year":"1995","unstructured":"Lefebvre S, Burglen L, Reboullet S, Clermont O, Burlet P, Viollet L, Benichou B, Cruaud C et al (1995) Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80:155\u2013165","journal-title":"Cell"},{"key":"1379_CR6","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","volume":"96","author":"CL Lorson","year":"1999","unstructured":"Lorson CL, Hahnen E, Androphy EJ, Wirth B (1999) A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc Natl Acad Sci U S A 96:6307\u20136311","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1379_CR7","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","volume":"8","author":"UR Monani","year":"1999","unstructured":"Monani UR, Lorson CL, Parsons DW, Prior TW, Androphy EJ, Burghes AH, McPherson JD (1999) A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2. Hum Mol Genet 8:1177\u20131183","journal-title":"Hum Mol Genet"},{"key":"1379_CR8","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/ng0797-265","volume":"16","author":"S Lefebvre","year":"1997","unstructured":"Lefebvre S, Burlet P, Liu Q, Bertrandy S, Clermont O, Munnich A, Dreyfuss G, Melki J (1997) Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet 16:265\u2013269","journal-title":"Nat Genet"},{"key":"1379_CR9","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","volume":"377","author":"RS Finkel","year":"2017","unstructured":"Finkel RS, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J, Chiriboga CA, Saito K et al (2017) Nusinersen versus sham control in infantile-onset spinal muscular atrophy. N Engl J Med 377:1723\u20131732","journal-title":"N Engl J Med"},{"key":"1379_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1517\/14728214.2015.1041375","volume":"20","author":"B Wirth","year":"2015","unstructured":"Wirth B, Barkats M, Martinat C, Sendtner M, Gillingwater TH (2015) Moving towards treatments for spinal muscular atrophy: hopes and limits. Expert Opin Emerg Drugs 20:353\u2013356","journal-title":"Expert Opin Emerg Drugs"},{"key":"1379_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2016.02.009","volume":"279","author":"ME Butchbach","year":"2016","unstructured":"Butchbach ME, Lumpkin CJ, Harris AW, Saieva L, Edwards JD, Workman E, Simard LR, Pellizzoni L et al (2016) Protective effects of butyrate-based compounds on a mouse model for spinal muscular atrophy. Exp Neurol 279:13\u201326","journal-title":"Exp Neurol"},{"key":"1379_CR12","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1093\/hmg\/ddr288","volume":"20","author":"DY Kwon","year":"2011","unstructured":"Kwon DY, Motley WW, Fischbeck KH, Burnett BG (2011) Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in mice. Hum Mol Genet 20:3667\u20133677","journal-title":"Hum Mol Genet"},{"key":"1379_CR13","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1128\/MCB.01262-08","volume":"29","author":"BG Burnett","year":"2009","unstructured":"Burnett BG, Mu\u00f1oz E, Tandon A, Kwon DY, Sumner CJ, Fischbeck KH (2009) Regulation of SMN protein stability. Mol Cell Biol 29:1107\u20131115","journal-title":"Mol Cell Biol"},{"key":"1379_CR14","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1093\/hmg\/ddi130","volume":"14","author":"LE Kernochan","year":"2005","unstructured":"Kernochan LE, Russo ML, Woodling NS, Huynh TN, Avila AM, Fischbeck KH, Sumner CJ (2005) The role of histone acetylation in SMN gene expression. Hum Mol Genet 14:1171\u20131182","journal-title":"Hum Mol Genet"},{"key":"1379_CR15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.expneurol.2016.06.032","volume":"283","author":"A Periyakaruppiah","year":"2016","unstructured":"Periyakaruppiah A, de la Fuente S, Arumugam S, Bahi N, Garcera A, Soler RM (2016) Autophagy modulators regulate survival motor neuron protein stability in motoneurons. Exp Neurol 283:287\u2013297","journal-title":"Exp Neurol"},{"key":"1379_CR16","doi-asserted-by":"publisher","first-page":"e686","DOI":"10.1038\/cddis.2013.209","volume":"4","author":"A Garcera","year":"2013","unstructured":"Garcera A, Bahi N, Periyakaruppiah A, Arumugam S, Soler RM (2013) Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro. Cell Death Dis 4:e686","journal-title":"Cell Death Dis"},{"key":"1379_CR17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.nbd.2016.01.008","volume":"88","author":"E Foran","year":"2016","unstructured":"Foran E, Kwon DY, Nofziger JH, Arnold ES, Hall MD, Fischbeck KH, Burnett BG (2016) CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy. Neurobiol Dis 88:118\u2013124","journal-title":"Neurobiol Dis"},{"key":"1379_CR18","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1152\/physrev.00029.2002","volume":"83","author":"DE Goll","year":"2003","unstructured":"Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83:731\u2013801","journal-title":"Physiol Rev"},{"key":"1379_CR19","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/ncomms2303","volume":"3","author":"T Yamashita","year":"2012","unstructured":"Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S (2012) A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nat Commun 3:1307","journal-title":"Nat Commun"},{"key":"1379_CR20","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/1097-4547(20000715)61:2<146::AID-JNR5>3.0.CO;2-C","volume":"61","author":"DC Shields","year":"2000","unstructured":"Shields DC, Schaecher KE, Hogan EL, Banik NL (2000) Calpain activity and expression increased in activated glial and inflammatory cells in penumbra of spinal cord injury lesion. J Neurosci Res 61:146\u2013150","journal-title":"J Neurosci Res"},{"key":"1379_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.02.004","volume":"105","author":"T Yamashima","year":"2013","unstructured":"Yamashima T (2013) Reconsider Alzheimer's disease by the \u2018calpain-cathepsin hypothesis\u2019\u2014a perspective review. Prog Neurobiol 105:1\u201323","journal-title":"Prog Neurobiol"},{"key":"1379_CR22","doi-asserted-by":"publisher","first-page":"12725","DOI":"10.1523\/JNEUROSCI.4619-08.2008","volume":"28","author":"CM Cowan","year":"2008","unstructured":"Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK, Hayden MR, Raymond LA (2008) Polyglutamine-modulated striatal calpain activity in YAC transgenic Huntington disease mouse model: impact on NMDA receptor function and toxicity. J Neurosci 28:12725\u201312735","journal-title":"J Neurosci"},{"key":"1379_CR23","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s12035-008-8036-x","volume":"38","author":"PS Vosler","year":"2008","unstructured":"Vosler PS, Brennan CS, Chen J (2008) Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Mol Neurobiol 38:78\u2013100","journal-title":"Mol Neurobiol"},{"key":"1379_CR24","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1093\/hmg\/ddn234","volume":"17","author":"MP Walker","year":"2008","unstructured":"Walker MP, Rajendra TK, Saieva L, Fuentes JL, Pellizzoni L, Matera AG (2008) SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. Hum Mol Genet 17:3399\u20133410","journal-title":"Hum Mol Genet"},{"key":"1379_CR25","doi-asserted-by":"publisher","first-page":"e15769","DOI":"10.1371\/journal.pone.0015769","volume":"5","author":"JL Fuentes","year":"2010","unstructured":"Fuentes JL, Strayer MS, Matera AG (2010) Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain. PLoS One 5:e15769","journal-title":"PLoS One"},{"key":"1379_CR26","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1111\/j.1471-4159.2009.06278.x","volume":"110","author":"M Gou-Fabregas","year":"2009","unstructured":"Gou-Fabregas M, Garcera A, Mincheva S, Perez-Garcia MJ, Comella JX, Soler RM (2009) Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization. J Neurochem 110:1842\u20131854","journal-title":"J Neurochem"},{"key":"1379_CR27","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.nbd.2011.02.003","volume":"42","author":"A Garcera","year":"2011","unstructured":"Garcera A, Mincheva S, Gou-Fabregas M, Caraballo-Miralles V, Llado J, Comella JX, Soler RM (2011) A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-X-L overexpression in motoneurons. Neurobiol Dis 42:415\u2013426","journal-title":"Neurobiol Dis"},{"key":"1379_CR28","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1523\/JNEUROSCI.18-04-01230.1998","volume":"18","author":"RM Soler","year":"1998","unstructured":"Soler RM, Egea J, Mintenig GM, Sanz-Rodriguez C, Iglesias M, Comella JX (1998) Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK-independent pathways. J Neurosci 18:1230\u20131239","journal-title":"J Neurosci"},{"key":"1379_CR29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/(SICI)1097-4547(19990101)55:1<119::AID-JNR13>3.0.CO;2-6","volume":"55","author":"V Arce","year":"1999","unstructured":"Arce V, Garces A, de Bovis B, Filippi P, Henderson C, Pettmann B, deLapeyriere O (1999) Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. J Neurosci Res 55:119\u2013126","journal-title":"J Neurosci Res"},{"key":"1379_CR30","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1523\/JNEUROSCI.0525-08.2008","volume":"28","author":"C Press","year":"2008","unstructured":"Press C, Milbrandt J (2008) Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci 28:4861\u20134871","journal-title":"J Neurosci"},{"key":"1379_CR31","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9:671\u2013675","journal-title":"Nat Methods"},{"key":"1379_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.expneurol.2008.02.025","volume":"212","author":"BF El-Khodor","year":"2008","unstructured":"El-Khodor BF, Edgar N, Chen A, Winberg ML, Joyce C, Brunner D, Su\u00e1rez-Fari\u00f1as M, Heyes MP (2008) Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of spinal muscular atrophy. Exp Neurol 212:29\u201343","journal-title":"Exp Neurol"},{"key":"1379_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0169-328X(97)00304-5","volume":"54","author":"E Adamec","year":"1998","unstructured":"Adamec E, Beermann ML, Nixon RA (1998) Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death. Brain Res Mol Brain Res 54:35\u201348","journal-title":"Brain Res Mol Brain Res"},{"issue":"Pt 3","key":"1379_CR34","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1042\/bj3190683","volume":"319","author":"R Nath","year":"1996","unstructured":"Nath R, Raser KJ, Stafford D, Hajimohammadreza I, Posner A, Allen H, Talanian RV, Yuen P et al (1996) Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem J 319(Pt 3):683\u2013690","journal-title":"Biochem J"},{"key":"1379_CR35","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1093\/hmg\/ddn189","volume":"17","author":"VL McGovern","year":"2008","unstructured":"McGovern VL, Gavrilina TO, Beattie CE, Burghes AH (2008) Embryonic motor axon development in the severe SMA mouse. Hum Mol Genet 17:2900\u20132909","journal-title":"Hum Mol Genet"},{"key":"1379_CR36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.nbd.2007.04.009","volume":"27","author":"ME Butchbach","year":"2007","unstructured":"Butchbach ME, Edwards JD, Burghes AH (2007) Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy. Neurobiol Dis 27:207\u2013219","journal-title":"Neurobiol Dis"},{"key":"1379_CR37","doi-asserted-by":"publisher","first-page":"13312","DOI":"10.1073\/pnas.230364197","volume":"97","author":"DA Kerr","year":"2000","unstructured":"Kerr DA, Nery JP, Traystman RJ, Chau BN, Hardwick JM (2000) Survival motor neuron protein modulates neuron-specific apoptosis. Proc Natl Acad Sci U S A 97:13312\u201313317","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1379_CR38","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1126\/science.1155085","volume":"320","author":"GE Oprea","year":"2008","unstructured":"Oprea GE, Kr\u00f6ber S, McWhorter ML, Rossoll W, M\u00fcller S, Krawczak M, Bassell GJ, Beattie CE et al (2008) Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy. Science 320:524\u2013527","journal-title":"Science"},{"key":"1379_CR39","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1096\/fj.06-7136com","volume":"21","author":"J Bergeijk van","year":"2007","unstructured":"van Bergeijk J, Rydel-K\u00f6necke K, Grothe C, Claus P (2007) The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C terminus. FASEB J 21:1492\u20131502","journal-title":"FASEB J"},{"key":"1379_CR40","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1523\/JNEUROSCI.4496-09.2010","volume":"30","author":"R Ruiz","year":"2010","unstructured":"Ruiz R, Casa\u00f1as JJ, Torres-Benito L, Cano R, Tabares L (2010) Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice. J Neurosci 30:849\u2013857","journal-title":"J Neurosci"},{"key":"1379_CR41","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1083\/jcb.200703187","volume":"179","author":"S Jablonka","year":"2007","unstructured":"Jablonka S, Beck M, Lechner BD, Mayer C, Sendtner M (2007) Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy. J Cell Biol 179:139\u2013149","journal-title":"J Cell Biol"},{"key":"1379_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nchembio.79","volume":"4","author":"A Williams","year":"2008","unstructured":"Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol 4:295\u2013305","journal-title":"Nat Chem Biol"},{"key":"1379_CR43","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1042\/BST20130134","volume":"41","author":"S Sarkar","year":"2013","unstructured":"Sarkar S (2013) Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. Biochem Soc Trans 41:1103\u20131130","journal-title":"Biochem Soc Trans"},{"key":"1379_CR44","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1038\/s41419-017-0086-4","volume":"8","author":"A Piras","year":"2017","unstructured":"Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, Puyal J, Garcera A et al (2017) Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis 8:3223","journal-title":"Cell Death Dis"},{"key":"1379_CR45","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fnmol.2016.00076","volume":"9","author":"S Oliv\u00e1n","year":"2016","unstructured":"Oliv\u00e1n S, Calvo AC, Rando A, Herrando-Grabulosa M, Manzano R, Zaragoza P, Tizzano EF, Aquilera J et al (2016) Neuroprotective effect of non-viral gene therapy treatment based on tetanus toxin C-fragment in a severe mouse model of spinal muscular atrophy. Front Mol Neurosci 9:76","journal-title":"Front Mol Neurosci"},{"key":"1379_CR46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.mcn.2014.06.006","volume":"61","author":"SK Custer","year":"2014","unstructured":"Custer SK, Androphy EJ (2014) Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy. Mol Cell Neurosci 61:133\u2013140","journal-title":"Mol Cell Neurosci"},{"key":"1379_CR47","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1172\/JCI95231","volume":"128","author":"N Rodriguez-Muela","year":"2018","unstructured":"Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL (2018) Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest 128:3008\u20133023","journal-title":"J Clin Invest"},{"key":"1379_CR48","doi-asserted-by":"publisher","first-page":"e89970","DOI":"10.1172\/jci.insight.89970","volume":"2","author":"KA Kaifer","year":"2017","unstructured":"Kaifer KA, Villal\u00f3n E, Osman EY, Glascock JJ, Arnold LL, Cornelison DD, Lorson CL (2017) Plastin-3 extends survival and reduces severity in mouse models of spinal muscular atrophy. JCI Insight 2:e89970","journal-title":"JCI Insight"},{"key":"1379_CR49","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jnc.13536","volume":"137","author":"MV Rao","year":"2016","unstructured":"Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA (2016) Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. J Neurochem 137:253\u2013265","journal-title":"J Neurochem"},{"key":"1379_CR50","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/jnc.13296","volume":"137","author":"AL Wright","year":"2016","unstructured":"Wright AL, Vissel B (2016) CAST your vote: is calpain inhibition the answer to ALS? J Neurochem 137:140\u2013141","journal-title":"J Neurochem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1379-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1379-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1379-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T19:15:51Z","timestamp":1571166951000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1379-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["1379"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1379-z","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"assertion":[{"value":"1 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}