{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:33:56Z","timestamp":1768736036914,"version":"3.49.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NIA AG18031 and NIA AG038834"],"award-info":[{"award-number":["NIA AG18031 and NIA AG038834"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s12035-018-1441-x","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T10:27:33Z","timestamp":1548930453000},"page":"1531-1538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["RETRACTED ARTICLE: Aluminum in Neurological and Neurodegenerative Disease"],"prefix":"10.1007","volume":"56","author":[{"given":"Donald R. C.","family":"McLachlan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Alexandrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aileen I.","family":"Pogue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maire E.","family":"Percy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore P. A.","family":"Kruck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhide","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan M.","family":"Sharfman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J.","family":"Lukiw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"1441_CR1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1017\/S0317167100029826","volume":"16","author":"DRC McLachlan","year":"1989","unstructured":"McLachlan DRC, Lukiw WJ, Kruck TPA (1989) New evidence for an active role of aluminum in Alzheimer\u2019s disease. Can J Neurol Sci 16:490\u2013497","journal-title":"Can J Neurol Sci"},{"key":"1441_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/BF01734059","volume":"12","author":"DRC McLachlan","year":"1990","unstructured":"McLachlan DRC, Lukiw WJ, Kruck TPA (1990) Aluminum altered transcription and the pathogenesis of Alzheimer\u2019s disease. Environ Geochem Health 12:103\u2013114. \nhttps:\/\/doi.org\/10.1007\/BF01734059","journal-title":"Environ Geochem Health"},{"key":"#cr-split#-1441_CR3.1","unstructured":"Martin RB (1992) Aluminum speciation in biology Ciba Foundation Symposium 169"},{"key":"#cr-split#-1441_CR3.2","unstructured":"Aluminum in Biology and Medicine A Wiley Interscience Publication John Wiley and Sons New York (1992) pp 5-25."},{"key":"1441_CR4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/(SICI)1520-670X(1998)11:4<419::AID-JTRA12>3.0.CO;2-T","volume":"11","author":"WJ Lukiw","year":"1998","unstructured":"Lukiw WJ (1998) Aluminum and gene transcription in Alzheimer\u2019s disease and related neurodegenerative disorders. J Trace Elem Exp Med 11:419\u2013420","journal-title":"J Trace Elem Exp Med"},{"key":"1441_CR5","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1023\/A:1007627725251","volume":"25","author":"WJ Lukiw","year":"2000","unstructured":"Lukiw WJ, Bazan NG (2000) Neuroinflammatory signaling upregulation in Alzheimer\u2019s disease. Neurochem Res 25:1173\u20131184","journal-title":"Neurochem Res"},{"key":"1441_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0006-8993(02)02305-3","volume":"933","author":"A Campbell","year":"2002","unstructured":"Campbell A, Yang EY, Tsai-Turton M, Bondy SC (2002) Pro-inflammatory effects of aluminum in human glioblastoma cells. Brain Res 933:60\u201365","journal-title":"Brain Res"},{"key":"1441_CR7","first-page":"1061","volume":"317","author":"DRC McLachlan","year":"1989","unstructured":"McLachlan DRC, Lukiw WJ, Mizzen CA, Kruck TPA (1989) Chromatin structure in Alzheimer\u2019s disease: effect on 5\u2032 leader sequence for NF-L gene and role of aluminum. Prog Clin Biol Res 317:1061\u20131075","journal-title":"Prog Clin Biol Res"},{"key":"1441_CR8","first-page":"793","volume":"145","author":"DRC McLachlan","year":"1991","unstructured":"McLachlan DRC, Kruck TPA, Lukiw WJ, Krishnan SS (1991) Would decreased aluminum ingestion reduce the incidence of Alzheimer\u2019s disease? CMAJ 145:793\u2013804","journal-title":"CMAJ"},{"key":"1441_CR9","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.jinorgbio.2005.04.021","volume":"99","author":"WJ Lukiw","year":"2005","unstructured":"Lukiw WJ, Percy ME, Kruck TPA (2005) Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture. J Inorg Biochem 99:1895\u20131898","journal-title":"J Inorg Biochem"},{"key":"1441_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3233\/JAD-121909","volume":"35","author":"JR Walton","year":"2013","unstructured":"Walton JR (2013) Aluminum involvement in the progression of Alzheimer\u2019s disease. J Alzheimers Dis 35:7\u201343. \nhttps:\/\/doi.org\/10.3233\/JAD-121909","journal-title":"J Alzheimers Dis"},{"key":"1441_CR11","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3233\/JAD-132204","volume":"40","author":"JR Walton","year":"2014","unstructured":"Walton JR (2014) Chronic aluminum intake causes Alzheimer\u2019s disease: applying Sir Austin Bradford Hill\u2019s causality criteria. J Alzheimers Dis 40:765\u2013838. \nhttps:\/\/doi.org\/10.3233\/JAD-132204","journal-title":"J Alzheimers Dis"},{"key":"1441_CR12","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3389\/fneur201400262","volume":"5","author":"AI Pogue","year":"2014","unstructured":"Pogue AI, Lukiw WJ (2014) The mobilization of aluminum into the biosphere. Front Neurol 5:262. \nhttps:\/\/doi.org\/10.3389\/fneur201400262","journal-title":"Front Neurol"},{"key":"1441_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/jjinorgbio201507009","volume":"152","author":"AI Pogue","year":"2015","unstructured":"Pogue AI, Dua P, Hill JM, Lukiw WJ (2015) Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice. J Inorg Biochem 152:206\u2013209. \nhttps:\/\/doi.org\/10.1016\/jjinorgbio201507009","journal-title":"J Inorg Biochem"},{"key":"1441_CR14","doi-asserted-by":"publisher","unstructured":"Pogue AI, Jaber V, Zhao Y, Lukiw WJ (2017) Systemic inflammation in C57BL\/6J mice receiving dietary aluminum sulfate; up-regulation of the pro-inflammatory cytokines IL-6 and TNF\u03b1 C-reactive protein (CRP) and miRNA-146a in blood serum. J Alzheimers Dis Parkinsonism 7(6). \nhttps:\/\/doi.org\/10.4172\/2161-04601000403","DOI":"10.4172\/2161-04601000403"},{"key":"1441_CR15","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1089\/ars20177272","volume":"28","author":"C Garza-Lomb\u00f3","year":"2018","unstructured":"Garza-Lomb\u00f3 C, Posadas Y, Quintanar L, Gonsebatt ME, Franco R (2018) Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress. Antioxid Redox Signal 28:1669\u20131703. \nhttps:\/\/doi.org\/10.1089\/ars20177272","journal-title":"Antioxid Redox Signal"},{"key":"1441_CR16","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1021\/ac60316a019","volume":"44","author":"SS Krishnan","year":"1972","unstructured":"Krishnan SS, Gillespie KA, McLachlan DRC (1972) Determination of aluminum in biological material by atomic absorption spectrophotometry. Anal Chem 44:1469\u20131470","journal-title":"Anal Chem"},{"key":"1441_CR17","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1023\/B:CEMN.0000022773.70722.b2","volume":"24","author":"TPA Kruck","year":"2004","unstructured":"Kruck TPA, Cui JG, Percy ME, Lukiw WJ (2004) Molecular shuttle chelation: the use of ascorbate desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum. Cell Mol Neurobiol 24:443\u2013459","journal-title":"Cell Mol Neurobiol"},{"key":"1441_CR18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/bpa12333","volume":"26","author":"R Kandimalla","year":"2016","unstructured":"Kandimalla R, Vallamkondu J, Corgiat EB, Gill KD (2016) Understanding aspects of aluminum exposure in Alzheimer\u2019s disease development. Brain Pathol 26:139\u2013154. \nhttps:\/\/doi.org\/10.1111\/bpa12333","journal-title":"Brain Pathol"},{"key":"1441_CR19","first-page":"1176","volume":"74","author":"M Kawahara","year":"2016","unstructured":"Kawahara M (2016) Link between aluminum neurotoxicity and neurodegenerative disorders. Nihon Rinsho 74:1176\u20131185","journal-title":"Nihon Rinsho"},{"key":"1441_CR20","unstructured":"Barbalace K. ECAl (2018); Environmental chemistry of aluminum; \nEnvironmentalChemistry.com\n\n, 1995-2018; \nhttps:\/\/environmentalchemistry.com\/yogi\/periodic\/Al.html\n\n; last accessed 20 November 2018"},{"key":"1441_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF00490271","volume":"40","author":"U De Boni","year":"1974","unstructured":"De Boni U, Scott JW, Crapper DR (1974) Intracellular aluminum binding; a histochemical study. Histochemistry 40:31\u201337","journal-title":"Histochemistry"},{"key":"1441_CR22","first-page":"291","volume":"8","author":"WJ Lukiw","year":"1987","unstructured":"Lukiw WJ, Kruck TPA, McLachlan DRC (1987) Alterations in human linker histone-DNA binding in the presence of aluminum salts in vitro and in Alzheimer's disease. Neurotoxicology 8:291\u2013301","journal-title":"Neurotoxicology"},{"key":"1441_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0014-5793(89)80929-9","volume":"253","author":"WJ Lukiw","year":"1989","unstructured":"Lukiw WJ, Kruck TP, McLachlan DR (1989) Linker histone-DNA complexes: enhanced stability in the presence of aluminum lactate and implications for Alzheimer\u2019s disease. FEBS Lett 253:59\u201362","journal-title":"FEBS Lett"},{"key":"1441_CR24","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1021\/bi00435a043","volume":"28","author":"PR Walker","year":"1989","unstructured":"Walker PR, LeBlanc J, Sikorska M (1989) Effects of aluminum and other cations on the structure of brain and liver chromatin. Biochemistry 28:3911\u20133915. \nhttps:\/\/doi.org\/10.1021\/bi00435a043","journal-title":"Biochemistry"},{"key":"1441_CR25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1126\/science.180.4085.511","volume":"180","author":"DR Crapper","year":"1973","unstructured":"Crapper DR, Krishnan SS, Dalton AJ (1973) Brain aluminum distribution in Alzheimer\u2019s disease and experimental neurofibrillary degeneration. Science 180:511\u2013351","journal-title":"Science"},{"key":"1441_CR26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1385\/JMN:11:1:67","volume":"11","author":"WJ Lukiw","year":"1998","unstructured":"Lukiw WJ, LeBlanc HJ, Carver LA, McLachlan DRC, Bazan NG (1998) Run-on gene transcription in human neocortical nuclei inhibition by nanomolar aluminum and implications for neurodegenerative disease. J Mol Neurosci 11:67\u201378","journal-title":"J Mol Neurosci"},{"key":"1441_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3233\/JAD-2005-8204","volume":"8","author":"PN Alexandrov","year":"2005","unstructured":"Alexandrov PN, Zhao Y, Pogue AI, Tarr MA, Kruck TP, Percy ME, Cui JG, Lukiw WJ (2005) Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis 8:117\u2013127","journal-title":"J Alzheimers Dis"},{"key":"1441_CR28","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.jinorgbio.2007.06.004","volume":"101","author":"WJ Lukiw","year":"2007","unstructured":"Lukiw WJ, Pogue AI (2007) Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells. J Inorg Biochem 101:1265\u20131269","journal-title":"J Inorg Biochem"},{"key":"1441_CR29","doi-asserted-by":"publisher","first-page":"31315","DOI":"10.1074\/jbcM805371200","volume":"283","author":"WJ Lukiw","year":"2008","unstructured":"Lukiw WJ, Zhao Y, Cui JG (2008) An NF-kB-sensitive micro RNA-146a mediated inflammatory circuit in Alzheimer disease and in stressed human-brain cells. J Biol Chem 283:31315\u201331322. \nhttps:\/\/doi.org\/10.1074\/jbcM805371200","journal-title":"J Biol Chem"},{"key":"1441_CR30","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/jjinorgbio200905012","volume":"103","author":"AI Pogue","year":"2009","unstructured":"Pogue AI, Li YY, Cui JG, Zhao Y, Kruck TPA, Percy ME, Tarr MA, Lukiw WJ (2009) Characterization of an NF-kB-regulated miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. J Inorg Biochem 103:1591\u20131595. \nhttps:\/\/doi.org\/10.1016\/jjinorgbio200905012","journal-title":"J Inorg Biochem"},{"key":"1441_CR31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/jmorpho201601001","volume":"100","author":"AI Pogue","year":"2016","unstructured":"Pogue AI, Lukiw WJ (2016) Aluminum the genetic apparatus of the human CNS and Alzheimer\u2019s disease (AD). Morphologie 100:56\u201364. \nhttps:\/\/doi.org\/10.1016\/jmorpho201601001","journal-title":"Morphologie"},{"key":"1441_CR32","doi-asserted-by":"publisher","unstructured":"Pogue AI, Lukiw WJ (2016) Natural and synthetic neurotoxins in our environment: from Alzheimer\u2019s disease (AD) to autism spectrum disorder (ASD). J Alzheimers Dis Parkinsonism 6(4). \nhttps:\/\/doi.org\/10.4172\/2161-0460.1000249","DOI":"10.4172\/2161-0460.1000249"},{"key":"1441_CR33","doi-asserted-by":"publisher","unstructured":"Bhattacharjee S, Zhao Y, Hill JM, Culicchia F, Kruck TPA, Percy ME, Pogue AI, Walton JR et al (2013) Selective accumulation of aluminum in cerebral arteries in Alzheimer\u2019s disease (AD). J Inorg Biochem 126:35\u201337. \nhttps:\/\/doi.org\/10.1016\/jjinorgbio201305007","DOI":"10.1016\/jjinorgbio201305007"},{"key":"1441_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/jmrgentox201402006","volume":"766","author":"SP D'Souza","year":"2014","unstructured":"D'Souza SP, Vijayalaxmi KK, Naik P (2014) Assessment of genotoxicity of aluminium acetate in bone marrow male germ cells and fetal liver cells of Swiss albino mice. Mutat Res Genet Toxicol Environ Mutagen 766:16\u201322. \nhttps:\/\/doi.org\/10.1016\/jmrgentox201402006","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"key":"1441_CR35","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/jjinorgbio201305010","volume":"128","author":"PN Alexandrov","year":"2013","unstructured":"Alexandrov PN, Zhao Y, Jones BM, Bhattacharjee S, Lukiw WJ (2013) Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line. J Inorg Biochem 128:267\u2013269. \nhttps:\/\/doi.org\/10.1016\/jjinorgbio201305010","journal-title":"J Inorg Biochem"},{"key":"1441_CR36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/jjinorgbio201507013","volume":"152","author":"PN Alexandrov","year":"2015","unstructured":"Alexandrov PN, Kruck TP, Lukiw WJ (2015) Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive protein (CRP) in human-brain microvessel endothelial cells (hBMECs). J Inorg Biochem 152:210\u2013213. \nhttps:\/\/doi.org\/10.1016\/jjinorgbio201507013","journal-title":"J Inorg Biochem"},{"key":"1441_CR37","doi-asserted-by":"publisher","unstructured":"Zhao Y, Bhattacharjee S, Jones BM, Dua P, Alexandrov PN, Hill JM, Lukiw WJ (2013) Regulation of TREM2 expression by an NF-\u043aB-sensitive miRNA-34a. Neuroreport 24:318\u2013323. \nhttps:\/\/doi.org\/10.1097\/WNR0b013e32835fb6b0","DOI":"10.1097\/WNR0b013e32835fb6b0"},{"key":"1441_CR38","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3389\/fneur201700670","volume":"8","author":"PN Alexandrov","year":"2017","unstructured":"Alexandrov PN, Zhao Y, Jaber V, Cong L, Lukiw WJ (2017) Deficits in the proline-rich synapse-associated Shank3 protein in multiple neuropsychiatric disorders. Front Neurol 8:670. \nhttps:\/\/doi.org\/10.3389\/fneur201700670","journal-title":"Front Neurol"},{"key":"1441_CR39","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S0140-6736(89)92596-8","volume":"1","author":"WJ Lukiw","year":"1989","unstructured":"Lukiw WJ, Kruck TP, McLachlan DRC (1989) Aluminum and the nucleus of nerve cells. Lancet 1:781","journal-title":"Lancet"},{"key":"1441_CR40","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0197-4580(92)90018-S","volume":"13","author":"WJ Lukiw","year":"1992","unstructured":"Lukiw WJ, Krishnan B, Wong L, Kruck TP, Bergeron C, McLachlan DRC (1992) Nuclear compartmentalization of aluminum in Alzheimer\u2019s disease (AD). Neurobiol Aging 13:115\u2013121","journal-title":"Neurobiol Aging"},{"key":"1441_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.15761\/IFNM1000214","volume":"5","author":"PN Alexandrov","year":"2018","unstructured":"Alexandrov PN, Pogue AI, Lukiw WJ (2018) Synergism in aluminum and mercury neurotoxicity. Integr Food Nutr Metab 5:3\u20137. \nhttps:\/\/doi.org\/10.15761\/IFNM1000214","journal-title":"Integr Food Nutr Metab"},{"key":"1441_CR42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12035-013-8595-3","volume":"50","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Bhattacharjee S, Jones BM, Hill J, Dua P, Lukiw WJ (2014a) Regulation of neurotropic signaling by the inducible NF-kB-sensitive miRNA-125b in Alzheimer\u2019s disease (AD) and in primary human neuronal-glial (HNG) cells. Mol Neurobiol 50:97\u2013106. \nhttps:\/\/doi.org\/10.1007\/s12035-013-8595-3","journal-title":"Mol Neurobiol"},{"key":"1441_CR43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fneur201400167","volume":"5","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Hill JM, Bhattacharjee S, Percy ME, Pogue AI, Lukiw WJ (2014b) Aluminum-induced amyloidogenesis and impairment in the clearance of amyloid peptides from the central nervous system in Alzheimer\u2019s disease. Front Neurol 5:167. \nhttps:\/\/doi.org\/10.3389\/fneur201400167","journal-title":"Front Neurol"},{"key":"1441_CR44","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1007\/s12035-015-9105-6","volume":"53","author":"C Clement","year":"2016","unstructured":"Clement C, Hill JM, Dua P, Culicchia F, Lukiw WJ (2016) Analysis of RNA from Alzheimer\u2019s disease post-mortem brain tissues. Mol Neurobiol 53:1322\u20131328. \nhttps:\/\/doi.org\/10.1007\/s12035-015-9105-6","journal-title":"Mol Neurobiol"},{"key":"1441_CR45","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1007\/s00415-016-8308-8","volume":"264","author":"P Castro","year":"2017","unstructured":"Castro P, Zaman S, Holland A (2017) Alzheimer\u2019s disease in people with Down\u2019s syndrome: the prospects for and the challenges of developing preventative treatments. J Neurol 264:804\u2013813. \nhttps:\/\/doi.org\/10.1007\/s00415-016-8308-8","journal-title":"J Neurol"},{"key":"1441_CR46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s40120-017-0071-y","volume":"6","author":"NC Lee","year":"2017","unstructured":"Lee NC, Chien YH, Hwu WL (2017) A review of biomarkers for Alzheimer\u2019s disease in Down syndrome. Neurol Ther 6:69\u201381. \nhttps:\/\/doi.org\/10.1007\/s40120-017-0071-y","journal-title":"Neurol Ther"},{"key":"1441_CR47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/jfreeradbiomed201708024","volume":"114","author":"P Zis","year":"2018","unstructured":"Zis P, Strydom A (2018) Clinical aspects and biomarkers of Alzheimer\u2019s disease in Down syndrome. Free Radic Biol Med 114:3\u20139. \nhttps:\/\/doi.org\/10.1016\/jfreeradbiomed201708024","journal-title":"Free Radic Biol Med"},{"key":"1441_CR48","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s11255-014-0752-8","volume":"46","author":"J Mardini","year":"2014","unstructured":"Mardini J, Lavergne V, Ghannoum M (2014) Aluminum transfer during dialysis: a systematic review. Int Urol Nephrol 46:1361\u20131365. \nhttps:\/\/doi.org\/10.1007\/s11255-014-0752-8","journal-title":"Int Urol Nephrol"},{"issue":"8","key":"1441_CR49","doi-asserted-by":"publisher","first-page":"e1603","DOI":"10.7759\/cureus","volume":"9","author":"S Vadakedath","year":"2017","unstructured":"Vadakedath S, Kandi V (2017) Dialysis: a review of the mechanisms underlying complications in the management of chronic renal failure. Cureus 9(8):e1603. \nhttps:\/\/doi.org\/10.7759\/cureus","journal-title":"Cureus"},{"key":"1441_CR50","unstructured":"Walsh B, Bazan NG, Gordon WG, Lai B, Vogt S, Lukiw WJ (2005) Trace metal analysis in Alzheimer\u2019s disease tissues using high brilliance X-Ray beams; Sixth Keele Meeting on Aluminium Department of Biology University of Aveiro PORTUGAL"},{"key":"1441_CR51","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nature09267","volume":"466","author":"H Guo","year":"2010","unstructured":"Guo H, Ingolia NT, Weissman JS, Bartel DP (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466:835\u2013840. \nhttps:\/\/doi.org\/10.1038\/nature09267","journal-title":"Nature"},{"key":"1441_CR52","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3389\/fnagi201700407","volume":"9","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Cong L, Lukiw WJ (2017) Lipopolysaccharide (LPS) accumulates in neocortical neurons of Alzheimer\u2019s disease (AD) brain and impairs transcription in human neuronal-glial primary co-cultures. Front Aging Neurosci 9:407. \nhttps:\/\/doi.org\/10.3389\/fnagi201700407","journal-title":"Front Aging Neurosci"},{"key":"1441_CR53","doi-asserted-by":"publisher","first-page":"9100","DOI":"10.1007\/s12035-018-1015-y","volume":"55","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Lukiw WJ (2018) Bacteroidetes neurotoxins and inflammatory neurodegeneration. Mol Neurobiol 55:9100\u20139107. \nhttps:\/\/doi.org\/10.1007\/s12035-018-1015-y","journal-title":"Mol Neurobiol"},{"key":"1441_CR54","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jmr.2003.12.013","volume":"170","author":"PL Bryant","year":"2004","unstructured":"Bryant PL, Lukiw WJ, Gan Z, Hall RW, Butler LG (2004) High-field 196T 27Al solid-state MAS NMR of in vitro aluminated brain tissue. J Magn Reson 170:257\u2013262","journal-title":"J Magn Reson"},{"key":"1441_CR55","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pnmrs.2016.01.003","volume":"94-95","author":"Mohamed Haouas","year":"2016","unstructured":"Haouas M, Taulelle F, Martineau C (2016) Recent advances in application of 27Al NMR spectroscopy to materials science. Prog Nucl Magn Reson Spectrosc 94-95:11\u201336. \nhttps:\/\/doi.org\/10.1016\/j.pnmrs.2016.01.003","journal-title":"Progress in Nuclear Magnetic Resonance Spectroscopy"},{"issue":"8753","key":"1441_CR56","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/0140-6736(91)92978-B","volume":"337","author":"D MCLACHLAN","year":"1991","unstructured":"McLachlan DRC, Dalton AJ, Kruck TP, Bell MY, Smith WL, Kalow W, Andrews DF (1991) Intramuscular desferrioxamine in patients with Alzheimer's disease. Lancet 337:1304\u20131308. PubMed PMID:1674295.","journal-title":"The Lancet"},{"key":"1441_CR57","unstructured":"McLachlan DRC, Fraser PE, Dalton AJ (1992) Aluminum and the pathogenesis of Alzheimer's disease: a summary of evidence. Ciba Found Symp 1992:169:87\u201398."}],"updated-by":[{"DOI":"10.1007\/s12035-020-01883-9","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"record-id":"22105"},{"DOI":"10.1007\/s12035-020-01883-9","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000}}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1441-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1441-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1441-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:16:17Z","timestamp":1600283777000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1441-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,31]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1441"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1441-x","relation":{"retraction":[{"id-type":"doi","id":"10.1007\/s12035-020-01883-9","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,31]]},"assertion":[{"value":"21 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Editor-in Chief of Molecular Neurobiology has retracted this article [1] at the request of the corresponding author.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2020","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Editor-in Chief of Molecular Neurobiology has retracted this article [1] at the request of the corresponding author. This is because it significantly overlaps with their previous publication [2]. Both articles report the same results and as such this article is redundant.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2020","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Editor-in Chief of Molecular Neurobiology has retracted this article [1] at the request of the corresponding author. This is because it significantly overlaps with their previous publication [2]. Both articles report the same results and as such this article is redundant.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All acquisition, handling, experimental, and analytical procedures involving postmortem human brain tissues were carried out in an ethical manner in strict accordance with the ethics review board policies at brain and tissue donor institutions and at the Louisiana State University (LSU) Health Sciences Center. Informed consent from next of kin was obtained at brain and tissue donor institutions for all tissue samples prior to autopsy and donation; coded postmortem brain tissue samples (containing no personal identifying information of the donors) were obtained from the 18 brain and tissue banks listed in the Acknowledgements section above. The ethical use of postmortem human brain tissues and their analyses were also carried out in strict accordance with the Institutional Biosafety Committee and the Institutional Review Board Committee (IBC\/IRBC) ethical guidelines IBC#18059 and IRBC#6774 at the LSU Health Sciences Center, New Orleans LA 70112 USA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Statement"}},{"value":"Declaration of interest for all authors including financial and personal relationships with other people or organizations: none. We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. The experimental and research work in this paper was funded by the LSU Eye Center from Research to Prevent Blindness (RPB), the Louisiana Biotechnology Research Network (LBRN), the National Institutes of Health (NIH), Bethesda MD, USA and the Alzheimer Association Chicago IL, USA, and was not supported by any pro- or anti-aluminum lobby or private foundation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}