{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:54:57Z","timestamp":1769522097759,"version":"3.49.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009531","name":"Istituto Italiano di Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12035-018-1465-2","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T13:26:16Z","timestamp":1546608376000},"page":"5392-5415","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antisense Transcription in Loci Associated to Hereditary Neurodegenerative Diseases"],"prefix":"10.1007","volume":"56","author":[{"name":"FANTOM Consortium","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Zucchelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Vatta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Calligaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Heutink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Rizzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Persichetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Kawaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Lassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Hayashizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Carninci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair R. R.","family":"Forrest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2749-2514","authenticated-orcid":false,"given":"Stefano","family":"Gustincich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"1465_CR1","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1126\/science.1112009","volume":"309","author":"S Katayama","year":"2005","unstructured":"Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC et al (2005) Antisense transcription in the mammalian transcriptome. Science 309:1564\u20131566","journal-title":"Science"},{"key":"1465_CR2","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1093\/nar\/gkh818","volume":"32","author":"J Chen","year":"2004","unstructured":"Chen J, Sun M, Kent WJ, Huang X, Xie H, Wang W, Zhou G, Shi RZ et al (2004) Over 20% of human transcripts might form sense-antisense pairs. Nucleic Acids Res 32:4812\u20134820","journal-title":"Nucleic Acids Res"},{"key":"1465_CR3","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1371\/journal.pgen.0020047","volume":"2","author":"PG Engstrom","year":"2006","unstructured":"Engstrom PG, Suzuki H, Ninomiya N, Akalin A, Sessa L, Lavorgna G, Brozzi A, Luzi L et al (2006) Complex loci in human and mouse genomes. PLoS Genet 2:e47","journal-title":"PLoS Genet"},{"key":"1465_CR4","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","volume":"22","author":"T Derrien","year":"2012","unstructured":"Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D et al (2012) The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 22:1775\u20131789","journal-title":"Genome Res"},{"key":"1465_CR5","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1101\/gr.135350.111","volume":"22","author":"J Harrow","year":"2012","unstructured":"Harrow J, Frankish A, Gonzalez JM, Tapanari E, Diekhans M, Kokocinski F, Aken BL, Barrell D et al (2012) GENCODE: the reference human genome annotation for the ENCODE Project. Genome Res 22:1760\u20131774","journal-title":"Genome Res"},{"key":"1465_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nature21374","volume":"543","author":"CC Hon","year":"2017","unstructured":"Hon CC, Ramilowski JA, Harshbarger J, Bertin N, Rackham OJ, Gough J, Denisenko E, Schmeier S et al (2017) An atlas of human long non-coding RNAs with accurate 5\u2032 ends. Nature 543:199\u2013204","journal-title":"Nature"},{"key":"1465_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.3192","volume":"47","author":"MK Iyer","year":"2015","unstructured":"Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR et al (2015) The landscape of long noncoding RNAs in the human transcriptome. Nat Genet 47:199\u2013208","journal-title":"Nat Genet"},{"key":"1465_CR8","doi-asserted-by":"publisher","first-page":"D168","DOI":"10.1093\/nar\/gku988","volume":"43","author":"XC Quek","year":"2015","unstructured":"Quek XC, Thomson DW, Maag JL, Bartonicek N, Signal B, Clark MB, Gloss BS, Dinger ME (2015) lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs. Nucleic Acids Res 43:D168\u2013D173","journal-title":"Nucleic Acids Res"},{"key":"1465_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cell.2010.09.001","volume":"143","author":"UA Orom","year":"2010","unstructured":"Orom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, Lai F, Zytnicki M et al (2010) Long noncoding RNAs with enhancer-like function in human cells. Cell 143:46\u201358","journal-title":"Cell"},{"key":"1465_CR10","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.cell.2012.03.035","volume":"149","author":"DS Cabianca","year":"2012","unstructured":"Cabianca DS, Casa V, Bodega B, Xynos A, Ginelli E, Tanaka Y, Gabellini D (2012) A long ncRNA links copy number variation to a polycomb\/trithorax epigenetic switch in FSHD muscular dystrophy. Cell 149:819\u2013831","journal-title":"Cell"},{"key":"1465_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nature19346","volume":"537","author":"JJ Kotzin","year":"2016","unstructured":"Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A et al (2016) The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 537:239\u2013243","journal-title":"Nature"},{"key":"1465_CR12","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","volume":"129","author":"JL Rinn","year":"2007","unstructured":"Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA et al (2007) Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129:1311\u20131323","journal-title":"Cell"},{"key":"1465_CR13","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/nature09819","volume":"472","author":"KC Wang","year":"2011","unstructured":"Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A et al (2011) A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 472:120\u2013124","journal-title":"Nature"},{"key":"1465_CR14","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.molcel.2009.01.026","volume":"33","author":"CM Clemson","year":"2009","unstructured":"Clemson CM, Hutchinson JN, Sara SA, Ensminger AW, Fox AH, Chess A, Lawrence JB (2009) An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell 33:717\u2013726","journal-title":"Mol Cell"},{"key":"1465_CR15","doi-asserted-by":"publisher","first-page":"456","DOI":"10.4161\/rna.23547","volume":"10","author":"T Naganuma","year":"2013","unstructured":"Naganuma T, Hirose T (2013) Paraspeckle formation during the biogenesis of long non-coding RNAs. RNA Biol 10:456\u2013461","journal-title":"RNA Biol"},{"key":"1465_CR16","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nsmb.2764","volume":"21","author":"E Hacisuleyman","year":"2014","unstructured":"Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG et al (2014) Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol 21:198\u2013206","journal-title":"Nat Struct Mol Biol"},{"key":"1465_CR17","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.molcel.2010.08.011","volume":"39","author":"V Tripathi","year":"2010","unstructured":"Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, Freier SM, Bennett CF et al (2010) The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39:925\u2013938","journal-title":"Mol Cell"},{"key":"1465_CR18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature09701","volume":"470","author":"C Gong","year":"2011","unstructured":"Gong C, Maquat LE (2011) lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3\u2019 UTRs via Alu elements. Nature 470:284\u2013288","journal-title":"Nature"},{"key":"1465_CR19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.cell.2011.09.028","volume":"147","author":"M Cesana","year":"2011","unstructured":"Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I (2011) A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 147:358\u2013369","journal-title":"Cell"},{"key":"1465_CR20","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2011.09.029","volume":"147","author":"Y Tay","year":"2011","unstructured":"Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L et al (2011) Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147:344\u2013357","journal-title":"Cell"},{"key":"1465_CR21","doi-asserted-by":"publisher","unstructured":"Wang P, Xu J, Wang Y, Cao X (2017) An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism. Science 24;358(6366):1051\u20131055. \n                    https:\/\/doi.org\/10.1126\/science.aao0409","DOI":"10.1126\/science.aao0409"},{"key":"1465_CR22","doi-asserted-by":"publisher","unstructured":"Gustincich S, Zucchelli S, Mallamaci A (2016) The Yin and Yang of nucleic acid-based therapy in the brain. Prog Neurobiol 155:194\u2013211. \n                    https:\/\/doi.org\/10.1016\/j.pneurobio.2016.11.001","DOI":"10.1016\/j.pneurobio.2016.11.001"},{"key":"1465_CR23","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nature06468","volume":"451","author":"W Yu","year":"2008","unstructured":"Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H (2008) Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451:202\u2013206","journal-title":"Nature"},{"key":"1465_CR24","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1101\/gad.455708","volume":"22","author":"M Beltran","year":"2008","unstructured":"Beltran M, Puig I, Pena C, Garcia JM, Alvarez AB, Pena R, Bonilla F, de Herreros AG (2008) A natural antisense transcript regulates Zeb2\/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev 22:756\u2013769","journal-title":"Genes Dev"},{"key":"1465_CR25","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1101\/gad.1654808","volume":"22","author":"AK Ebralidze","year":"2008","unstructured":"Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V et al (2008) PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. Genes Dev 22:2085\u20132092","journal-title":"Genes Dev"},{"key":"1465_CR26","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nsmb.3005","volume":"22","author":"I Gonzalez","year":"2015","unstructured":"Gonzalez I, Munita R, Agirre E, Dittmer TA, Gysling K, Misteli T, Luco RF (2015) A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature. Nat Struct Mol Biol 22:370\u2013376","journal-title":"Nat Struct Mol Biol"},{"key":"1465_CR27","doi-asserted-by":"publisher","first-page":"11507","DOI":"10.1074\/jbc.275.15.11507","volume":"275","author":"ML Hastings","year":"2000","unstructured":"Hastings ML, Ingle HA, Lazar MA, Munroe SH (2000) Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA. J Biol Chem 275:11507\u201311513","journal-title":"J Biol Chem"},{"key":"1465_CR28","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","volume":"142","author":"M Huarte","year":"2010","unstructured":"Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O et al (2010) A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142:409\u2013419","journal-title":"Cell"},{"key":"1465_CR29","doi-asserted-by":"publisher","first-page":"e8658","DOI":"10.1371\/journal.pone.0008658","volume":"5","author":"G Spigoni","year":"2010","unstructured":"Spigoni G, Gedressi C, Mallamaci A (2010) Regulation of Emx2 expression by antisense transcripts in murine cortico-cerebral precursors. PLoS One 5:e8658","journal-title":"PLoS One"},{"key":"1465_CR30","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/nature11508","volume":"491","author":"C Carrieri","year":"2012","unstructured":"Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I et al (2012) Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature 491:454\u2013457","journal-title":"Nature"},{"key":"1465_CR31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/ng1157","volume":"34","author":"C Tufarelli","year":"2003","unstructured":"Tufarelli C, Stanley JA, Garrick D, Sharpe JA, Ayyub H, Wood WG, Higgs DR (2003) Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease. Nat Genet 34:157\u2013165","journal-title":"Nat Genet"},{"key":"1465_CR32","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1093\/hmg\/ddm293","volume":"16","author":"PD Ladd","year":"2007","unstructured":"Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, Hagerman RJ, Tassone F et al (2007) An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals. Hum Mol Genet 16:3174\u20133187","journal-title":"Hum Mol Genet"},{"key":"1465_CR33","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nm1784","volume":"14","author":"MA Faghihi","year":"2008","unstructured":"Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G 3rd et al (2008) Expression of a noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of beta-secretase. Nat Med 14:723\u2013730","journal-title":"Nat Med"},{"key":"1465_CR34","doi-asserted-by":"publisher","first-page":"R56","DOI":"10.1186\/gb-2010-11-5-r56","volume":"11","author":"MA Faghihi","year":"2010","unstructured":"Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G 3rd et al (2010) Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol 11:R56","journal-title":"Genome Biol"},{"key":"1465_CR35","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1093\/hmg\/ddr263","volume":"20","author":"DW Chung","year":"2011","unstructured":"Chung DW, Rudnicki DD, Yu L, Margolis RL (2011) A natural antisense transcript at the Huntington\u2019s disease repeat locus regulates HTT expression. Hum Mol Genet 20:3467\u20133477","journal-title":"Hum Mol Genet"},{"key":"1465_CR36","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.neuron.2011.05.027","volume":"70","author":"BL Sopher","year":"2011","unstructured":"Sopher BL, Ladd PD, Pineda VV, Libby RT, Sunkin SM, Hurley JB, Thienes CP, Gaasterland T et al (2011) CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA. Neuron 70:1071\u20131084","journal-title":"Neuron"},{"key":"1465_CR37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1471-2164-8-74","volume":"8","author":"C Scheele","year":"2007","unstructured":"Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L et al (2007) The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. BMC Genomics 8:74","journal-title":"BMC Genomics"},{"key":"1465_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","volume":"72","author":"M DeJesus-Hernandez","year":"2011","unstructured":"DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA et al (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72:245\u2013256","journal-title":"Neuron"},{"key":"1465_CR39","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","volume":"72","author":"AE Renton","year":"2011","unstructured":"Renton AE, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H et al (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72:257\u2013268","journal-title":"Neuron"},{"key":"1465_CR40","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1126\/science.1232927","volume":"339","author":"K Mori","year":"2013","unstructured":"Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA et al (2013) The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD\/ALS. Science 339:1335\u20131338","journal-title":"Science"},{"key":"1465_CR41","doi-asserted-by":"publisher","first-page":"E4968","DOI":"10.1073\/pnas.1315438110","volume":"110","author":"T Zu","year":"2013","unstructured":"Zu T, Liu Y, Banez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB et al (2013) RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proc Natl Acad Sci U S A 110:E4968\u2013E4977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1465_CR42","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40478-016-0306-7","volume":"4","author":"P Rizzu","year":"2016","unstructured":"Rizzu P, Blauwendraat C, Heetveld S, Lynes EM, Castillo-Lizardo M, Dhingra A, Pyz E, Hobert M et al (2016) C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers. Acta Neuropathol Commun 4:37","journal-title":"Acta Neuropathol Commun"},{"key":"1465_CR43","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.nbd.2007.04.014","volume":"27","author":"JM Taylor","year":"2007","unstructured":"Taylor JM, Song YJ, Huang Y, Farrer MJ, Delatycki MB, Halliday GM, Lockhart PJ (2007) Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases. Neurobiol Dis 27:238\u2013247","journal-title":"Neurobiol Dis"},{"key":"1465_CR44","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/ng1789","volume":"38","author":"P Carninci","year":"2006","unstructured":"Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS et al (2006) Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet 38:626\u2013635","journal-title":"Nat Genet"},{"key":"1465_CR45","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/ng.375","volume":"41","author":"H Suzuki","year":"2009","unstructured":"Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T et al (2009) The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet 41:553\u2013562","journal-title":"Nat Genet"},{"key":"1465_CR46","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1101\/gr.115469.110","volume":"21","author":"M Kanamori-Katayama","year":"2011","unstructured":"Kanamori-Katayama M, Itoh M, Kawaji H, Lassmann T, Katayama S, Kojima M, Bertin N, Kaiho A et al (2011) Unamplified cap analysis of gene expression on a single-molecule sequencer. Genome Res 21:1150\u20131159","journal-title":"Genome Res"},{"key":"1465_CR47","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature12787","volume":"507","author":"R Andersson","year":"2014","unstructured":"Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X et al (2014) An atlas of active enhancers across human cell types and tissues. Nature 507:455\u2013461","journal-title":"Nature"},{"key":"1465_CR48","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1126\/science.1259418","volume":"347","author":"E Arner","year":"2015","unstructured":"Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drablos F, Lennartsson A, Ronnerblad M et al (2015) Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 347:1010\u20131014","journal-title":"Science"},{"key":"1465_CR49","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nature13182","volume":"507","author":"AR Forrest","year":"2014","unstructured":"Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassman T, Kulakovskiy IV et al (2014) A promoter-level mammalian expression atlas. Nature 507:462\u2013470","journal-title":"Nature"},{"key":"1465_CR50","doi-asserted-by":"publisher","first-page":"W147","DOI":"10.1093\/nar\/gkw419","volume":"44","author":"S Babicki","year":"2016","unstructured":"Babicki S, Arndt D, Marcu A, Liang Y, Grant JR, Maciejewski A, Wishart DS (2016) Heatmapper: web-enabled heat mapping for all. Nucleic Acids Res 44:W147\u2013W153","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 1","key":"1465_CR51","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/S1353-8020(13)70009-9","volume":"20","author":"V Bonifati","year":"2014","unstructured":"Bonifati V (2014) Genetics of Parkinson\u2019s disease\u2014state of the art, 2013. Parkinsonism Relat Disord 20(Suppl 1):S23\u2013S28","journal-title":"Parkinsonism Relat Disord"},{"key":"1465_CR52","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13059-017-1147-9","volume":"18","author":"IE Jansen","year":"2017","unstructured":"Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, Lubbe SJ, Drouet V et al (2017) Discovery and functional prioritization of Parkinson\u2019s disease candidate genes from large-scale whole exome sequencing. Genome Biol 18:22","journal-title":"Genome Biol"},{"key":"1465_CR53","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ajmg.b.32499","volume":"174","author":"AC Naj","year":"2017","unstructured":"Naj AC, Schellenberg GD, Alzheimer\u2019s Disease Genetics C (2017) Genomic variants, genes, and pathways of Alzheimer\u2019s disease: an overview. Am J Med Genet B Neuropsychiatr Genet 174:5\u201326","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"1465_CR54","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11910-016-0707-9","volume":"16","author":"DA Olszewska","year":"2016","unstructured":"Olszewska DA, Lonergan R, Fallon EM, Lynch T (2016) Genetics of frontotemporal dementia. Curr Neurol Neurosci Rep 16:107","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1465_CR55","doi-asserted-by":"crossref","unstructured":"Scott L, Dawson VL, Dawson TM (2017) Trumping neurodegeneration: targeting common pathways regulated by autosomal recessive Parkinson\u2019s disease genes. Neurol Exp","DOI":"10.1016\/j.expneurol.2017.04.008"},{"key":"1465_CR56","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.ajhg.2016.01.014","volume":"98","author":"S Lesage","year":"2016","unstructured":"Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM et al (2016) Loss of VPS13C function in autosomal-recessive Parkinsonism causes mitochondrial dysfunction and increases PINK1\/Parkin-dependent mitophagy. Am J Hum Genet 98:500\u2013513","journal-title":"Am J Hum Genet"},{"key":"1465_CR57","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ajhg.2011.06.001","volume":"89","author":"C Vilarino-Guell","year":"2011","unstructured":"Vilarino-Guell C, Wider C, Ross OA, Dachsel JC, Kachergus JM, Lincoln SJ, Soto-Ortolaza AI, Cobb SA et al (2011) VPS35 mutations in Parkinson disease. Am J Hum Genet 89:162\u2013167","journal-title":"Am J Hum Genet"},{"key":"1465_CR58","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ajhg.2011.06.008","volume":"89","author":"A Zimprich","year":"2011","unstructured":"Zimprich A, Benet-Pages A, Struhal W, Graf E, Eck SH, Offman MN, Haubenberger D, Spielberger S et al (2011) A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet 89:168\u2013175","journal-title":"Am J Hum Genet"},{"key":"1465_CR59","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13059-014-0560-6","volume":"16","author":"M Lizio","year":"2015","unstructured":"Lizio M, Harshbarger J, Shimoji H, Severin J, Kasukawa T, Sahin S, Abugessaisa I, Fukuda S et al (2015) Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol 16:22","journal-title":"Genome Biol"},{"key":"1465_CR60","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nbt.2840","volume":"32","author":"J Severin","year":"2014","unstructured":"Severin J, Lizio M, Harshbarger J, Kawaji H, Daub CO, Hayashizaki Y, Bertin N, Forrest AR (2014) Interactive visualization and analysis of large-scale sequencing datasets using ZENBU. Nat Biotechnol 32:217\u2013219","journal-title":"Nat Biotechnol"},{"key":"1465_CR61","doi-asserted-by":"publisher","first-page":"E2079","DOI":"10.1002\/humu.21459","volume":"32","author":"E Mutez","year":"2011","unstructured":"Mutez E, Lepretre F, Le Rhun E, Larvor L, Duflot A, Mouroux V, Kerckaert JP, Figeac M et al (2011) SNCA locus duplication carriers: from genetics to Parkinson disease phenotypes. Hum Mutat 32:E2079\u2013E2090","journal-title":"Hum Mutat"},{"key":"1465_CR62","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1090278","volume":"302","author":"AB Singleton","year":"2003","unstructured":"Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T et al (2003) alpha-Synuclein locus triplication causes Parkinson\u2019s disease. Science 302:841","journal-title":"Science"},{"key":"1465_CR63","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1038\/ncomms6336","volume":"5","author":"R Andersson","year":"2014","unstructured":"Andersson R, Refsing Andersen P, Valen E, Core LJ, Bornholdt J, Boyd M, Heick Jensen T, Sandelin A (2014) Nuclear stability and transcriptional directionality separate functionally distinct RNA species. Nat Commun 5:5336","journal-title":"Nat Commun"},{"key":"1465_CR64","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/ng.3142","volume":"46","author":"LJ Core","year":"2014","unstructured":"Core LJ, Martins AL, Danko CG, Waters CT, Siepel A, Lis JT (2014) Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers. Nat Genet 46:1311\u20131320","journal-title":"Nat Genet"},{"key":"1465_CR65","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/nn.4126","volume":"18","author":"G Chan","year":"2015","unstructured":"Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ et al (2015) CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci 18:1556\u20131558","journal-title":"Nat Neurosci"},{"key":"1465_CR66","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","volume":"78","author":"A Griciuc","year":"2013","unstructured":"Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH et al (2013) Alzheimer\u2019s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78:631\u2013643","journal-title":"Neuron"},{"key":"1465_CR67","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","volume":"160","author":"Y Wang","year":"2015","unstructured":"Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM et al (2015) TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model. Cell 160:1061\u20131071","journal-title":"Cell"},{"key":"1465_CR68","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1126\/science.aaf1064","volume":"351","author":"JG O\u2019Rourke","year":"2016","unstructured":"O\u2019Rourke JG, Bogdanik L, Yanez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S et al (2016) C9orf72 is required for proper macrophage and microglial function in mice. Science 351:1324\u20131329","journal-title":"Science"},{"key":"1465_CR69","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/ng.803","volume":"43","author":"P Hollingworth","year":"2011","unstructured":"Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML et al (2011) Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer\u2019s disease. Nat Genet 43:429\u2013435","journal-title":"Nat Genet"},{"key":"1465_CR70","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/ng.801","volume":"43","author":"AC Naj","year":"2011","unstructured":"Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD et al (2011) Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease. Nat Genet 43:436\u2013441","journal-title":"Nat Genet"},{"key":"1465_CR71","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","volume":"153","author":"B Zhang","year":"2013","unstructured":"Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T et al (2013) Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer\u2019s disease. Cell 153:707\u2013720","journal-title":"Cell"},{"key":"1465_CR72","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1038\/nm.2965","volume":"18","author":"J Vom Berg","year":"2012","unstructured":"Vom Berg J, Prokop S, Miller KR, Obst J, Kalin RE, Lopategui-Cabezas I, Wegner A, Mair F et al (2012) Inhibition of IL-12\/IL-23 signaling reduces Alzheimer\u2019s disease-like pathology and cognitive decline. Nat Med 18:1812\u20131819","journal-title":"Nat Med"},{"key":"1465_CR73","doi-asserted-by":"publisher","first-page":"e1006482","DOI":"10.1371\/journal.pgen.1006482","volume":"12","author":"J Plassais","year":"2016","unstructured":"Plassais J, Lagoutte L, Correard S, Paradis M, Guaguere E, Hedan B, Pommier A, Botherel N et al (2016) A point mutation in a lincRNA upstream of GDNF is associated to a canine insensitivity to pain: a spontaneous model for human sensory neuropathies. PLoS Genet 12:e1006482","journal-title":"PLoS Genet"},{"key":"1465_CR74","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13073-016-0320-1","volume":"8","author":"C Blauwendraat","year":"2016","unstructured":"Blauwendraat C, Francescatto M, Gibbs JR, Jansen IE, Simon-Sanchez J, Hernandez DG, Dillman AA, Singleton AB et al (2016) Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe. Genome Med 8:65","journal-title":"Genome Med"},{"key":"1465_CR75","doi-asserted-by":"publisher","unstructured":"Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R et al (2017) Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy. EMBO Mol Med 10(1):107\u2013120. \n                    https:\/\/doi.org\/10.15252\/emmm.201707838","DOI":"10.15252\/emmm.201707838"},{"key":"1465_CR76","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.1093\/hmg\/ddu334","volume":"23","author":"J Bras","year":"2014","unstructured":"Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA et al (2014) Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Hum Mol Genet 23:6139\u20136146","journal-title":"Hum Mol Genet"},{"key":"1465_CR77","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/ana.24664","volume":"79","author":"I Guella","year":"2016","unstructured":"Guella I, Evans DM, Szu-Tu C, Nosova E, Bortnick SF, Group SCS, Goldman JG, Dalrymple-Alford JC et al (2016) Alpha-synuclein genetic variability: a biomarker for dementia in Parkinson disease. Ann Neurol 79:991\u2013999","journal-title":"Ann Neurol"},{"key":"1465_CR78","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2158","volume":"30","author":"F Modarresi","year":"2012","unstructured":"Modarresi F, Faghihi MA, Lopez-Toledano MA, Fatemi RP, Magistri M, Brothers SP, van der Brug MP, Wahlestedt C (2012) Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol 30:453\u2013459","journal-title":"Nat Biotechnol"},{"key":"1465_CR79","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.addr.2015.05.012","volume":"87","author":"O Khorkova","year":"2015","unstructured":"Khorkova O, Hsiao J, Wahlestedt C (2015) Basic biology and therapeutic implications of lncRNA. Adv Drug Deliv Rev 87:15\u201324","journal-title":"Adv Drug Deliv Rev"},{"key":"1465_CR80","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1186\/s12864-015-2058-3","volume":"16","author":"R Calligaris","year":"2015","unstructured":"Calligaris R, Banica M, Roncaglia P, Robotti E, Finaurini S, Vlachouli C, Antonutti L, Iorio F et al (2015) Blood transcriptomics of drug-naive sporadic Parkinson\u2019s disease patients. BMC Genomics 16:876","journal-title":"BMC Genomics"},{"key":"1465_CR81","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3233\/JPD-150737","volume":"6","author":"A Hossein-Nezhad","year":"2016","unstructured":"Hossein-Nezhad A, Fatemi RP, Ahmad R, Peskind ER, Zabetian CP, Hu SC, Shi M, Wahlestedt C et al (2016) Transcriptomic profiling of extracellular RNAs present in cerebrospinal fluid identifies differentially expressed transcripts in Parkinson\u2019s disease. J Parkinsons Dis 6:109\u2013117","journal-title":"J Parkinsons Dis"},{"key":"1465_CR82","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.coph.2015.10.007","volume":"26","author":"A Simchovitz","year":"2016","unstructured":"Simchovitz A, Soreq L, Soreq H (2016) Transcriptome profiling in Parkinson\u2019s leukocytes: from early diagnostics to neuroimmune therapeutic prospects. Curr Opin Pharmacol 26:102\u2013109","journal-title":"Curr Opin Pharmacol"},{"key":"1465_CR83","doi-asserted-by":"publisher","first-page":"e1003517","DOI":"10.1371\/journal.pcbi.1003517","volume":"10","author":"L Soreq","year":"2014","unstructured":"Soreq L, Guffanti A, Salomonis N, Simchovitz A, Israel Z, Bergman H, Soreq H (2014) Long non-coding RNA and alternative splicing modulations in Parkinson\u2019s leukocytes identified by RNA sequencing. PLoS Comput Biol 10:e1003517","journal-title":"PLoS Comput Biol"},{"key":"1465_CR84","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1016\/j.neurobiolaging.2015.07.015","volume":"36","author":"X Zhou","year":"2015","unstructured":"Zhou X, Xu J (2015) Identification of Alzheimer\u2019s disease-associated long noncoding RNAs. Neurobiol Aging 36:2925\u20132931","journal-title":"Neurobiol Aging"},{"key":"1465_CR85","doi-asserted-by":"publisher","first-page":"27315","DOI":"10.1038\/srep27315","volume":"6","author":"A Indrieri","year":"2016","unstructured":"Indrieri A, Grimaldi C, Zucchelli S, Tammaro R, Gustincich S, Franco B (2016) Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo. Sci Rep 6:27315","journal-title":"Sci Rep"},{"key":"1465_CR86","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1080\/15476286.2015.1060395","volume":"12","author":"S Zucchelli","year":"2015","unstructured":"Zucchelli S, Cotella D, Takahashi H, Carrieri C, Cimatti L, Fasolo F, Jones MH, Sblattero D et al (2015) SINEUPs: a new class of natural and synthetic antisense long non-coding RNAs that activate translation. RNA Biol 12:771\u2013779","journal-title":"RNA Biol"},{"key":"1465_CR87","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fncel.2015.00174","volume":"9","author":"S Zucchelli","year":"2015","unstructured":"Zucchelli S, Fasolo F, Russo R, Cimatti L, Patrucco L, Takahashi H, Jones MH, Santoro C et al (2015) SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells. Front Cell Neurosci 9:174","journal-title":"Front Cell Neurosci"},{"key":"1465_CR88","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nrd4018","volume":"12","author":"C Wahlestedt","year":"2013","unstructured":"Wahlestedt C (2013) Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov 12:433\u2013446","journal-title":"Nat Rev Drug Discov"},{"key":"1465_CR89","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neuron.2016.11.033","volume":"93","author":"C d\u2019Ydewalle","year":"2017","unstructured":"d\u2019Ydewalle C, Ramos DM, Pyles NJ, Ng SY, Gorz M, Pilato CM, Ling K, Kong L et al (2017) The antisense transcript SMN-AS1 regulates SMN expression and is a novel therapeutic target for spinal muscular atrophy. Neuron 93:66\u201379","journal-title":"Neuron"},{"key":"1465_CR90","doi-asserted-by":"publisher","first-page":"E1509","DOI":"10.1073\/pnas.1616521114","volume":"114","author":"CJ Woo","year":"2017","unstructured":"Woo CJ, Maier VK, Davey R, Brennan J, Li G, Brothers J 2nd, Schwartz B, Gordo S et al (2017) Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy. Proc Natl Acad Sci U S A 114:E1509\u2013E1518","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1465-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-018-1465-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-018-1465-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T19:03:44Z","timestamp":1578078224000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-018-1465-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1465"],"URL":"https:\/\/doi.org\/10.1007\/s12035-018-1465-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"assertion":[{"value":"3 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}