{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:45:14Z","timestamp":1790394314418,"version":"4.1.0"},"reference-count":152,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["IT989-16"],"award-info":[{"award-number":["IT989-16"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s12035-019-01676-9","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T13:08:08Z","timestamp":1561468088000},"page":"8376-8391","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["A Systematic Review of MicroRNA Expression as Biomarker of Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"56","author":[{"given":"Soraya","family":"Herrera-Espejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Santos-Zorrozua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"\u00c1lvarez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-3031","authenticated-orcid":false,"given":"Elixabet","family":"Lopez-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1frica","family":"Garcia-Orad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"issue":"1","key":"1676_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JAD-150451","volume":"49","author":"Y Pan","year":"2016","unstructured":"Pan Y, Liu R, Terpstra E, Wang Y, Qiao F, Wang J et al (2016) Dysregulation and diagnostic potential of microRNA in Alzheimer\u2019s disease. J Alzheimers Dis 49(1):1\u201312","journal-title":"J Alzheimers Dis"},{"key":"1676_CR2","unstructured":"Disease AAs (2018). Association Alzheimer\u2019s Disease. https:\/\/www.alz.org\/global\/overview.asp . Accessed 2018."},{"issue":"4","key":"1676_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/alzrt85","volume":"3","author":"C Wattmo","year":"2011","unstructured":"Wattmo C, Wallin AK, Londos E, Minthon L (2011) Predictors of long-term cognitive outcome in Alzheimer\u2019s disease. Alzheimers Res Ther 3(4):23","journal-title":"Alzheimers Res Ther"},{"issue":"8","key":"1676_CR4","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1016\/j.neurobiolaging.2015.04.011","volume":"36","author":"R Ossenkoppele","year":"2015","unstructured":"Ossenkoppele R, Mattsson N, Teunissen CE, Barkhof F, Pijnenburg Y, Scheltens P et al (2015) Cerebrospinal fluid biomarkers and cerebral atrophy in distinct clinical variants of probable Alzheimer\u2019s disease. Neurobiol Aging 36(8):2340\u20132347","journal-title":"Neurobiol Aging"},{"issue":"2","key":"1676_CR5","doi-asserted-by":"publisher","first-page":"e89019","DOI":"10.1371\/journal.pone.0089019","volume":"9","author":"L Cui","year":"2014","unstructured":"Cui L, Li Y, Ma G, Wang Y, Cai Y, Liu S et al (2014) A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients. PLoS One 9(2):e89019","journal-title":"PLoS One"},{"issue":"7","key":"1676_CR6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1212\/WNL.0b013e3182477eed","volume":"78","author":"N Mattsson","year":"2012","unstructured":"Mattsson N, Ros\u00e9n E, Hansson O, Andreasen N, Parnetti L, Jonsson M et al (2012) Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology. 78(7):468\u2013476","journal-title":"Neurology."},{"issue":"2","key":"1676_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116(2):281\u2013297","journal-title":"Cell."},{"issue":"1","key":"1676_CR8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","volume":"19","author":"RC Friedman","year":"2009","unstructured":"Friedman RC, Farh KK, Burge CB, Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19(1):92\u2013105. https:\/\/doi.org\/10.1101\/gr.082701.108","journal-title":"Genome Res"},{"issue":"3","key":"1676_CR9","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s12185-014-1606-y","volume":"100","author":"TM Johanson","year":"2014","unstructured":"Johanson TM, Skinner JP, Kumar A, Zhan Y, Lew AM, Chong MM (2014) The role of microRNAs in lymphopoiesis. Int J Hematol 100(3):246\u2013253. https:\/\/doi.org\/10.1007\/s12185-014-1606-y","journal-title":"Int J Hematol"},{"key":"1676_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fnagi.2018.00139","volume":"10","author":"SZA Shah","year":"2018","unstructured":"Shah SZA, Zhao D, Hussain T, Sabir N, Yang L (2018) Regulation of microRNAs-mediated autophagic flux: a new regulatory avenue for neurodegenerative diseases with focus on prion diseases. Front Aging Neurosci 10:139","journal-title":"Front Aging Neurosci"},{"issue":"9","key":"1676_CR11","doi-asserted-by":"publisher","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","volume":"3","author":"S Gilad","year":"2008","unstructured":"Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N et al (2008) Serum microRNAs are promising novel biomarkers. PLoS One 3(9):e3148","journal-title":"PLoS One"},{"issue":"3","key":"1676_CR12","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3233\/JAD-161257","volume":"58","author":"M Edsbagge","year":"2017","unstructured":"Edsbagge M, Andreasson U, Ambarki K, Wikkels\u00f8 C, Eklund A, Blennow K et al (2017) Alzheimer\u2019s disease-associated cerebrospinal fluid (CSF) biomarkers do not correlate with CSF volumes or CSF production rate. J Alzheimers Dis 58(3):821\u2013828. https:\/\/doi.org\/10.3233\/JAD-161257","journal-title":"J Alzheimers Dis"},{"key":"1676_CR13","unstructured":"Web, Science o. Web of Science core collection. https:\/\/apps.webofknowledge.com\/WOS_GeneralSearch_input.do?product=WOS&SID=F3C19V4ITCwyVekjgNr&search_mode=GeneralSearch . Accessed 2019."},{"key":"1676_CR14","unstructured":"PubMed. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/ Accessed 2018."},{"issue":"5","key":"1676_CR15","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","volume":"44","author":"H Dweep","year":"2011","unstructured":"Dweep H, Sticht C, Pandey P, Gretz N (2011) miRWalk--database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes. J Biomed Inform 44(5):839\u2013847. https:\/\/doi.org\/10.1016\/j.jbi.2011.05.002","journal-title":"J Biomed Inform"},{"issue":"Database issue","key":"1676_CR16","doi-asserted-by":"publisher","first-page":"D623","DOI":"10.1093\/nar\/gkn698","volume":"37","author":"A Kamburov","year":"2009","unstructured":"Kamburov A, Wierling C, Lehrach H, Herwig R (2009) ConsensusPathDB--a database for integrating human functional interaction networks. Nucleic Acids Res 37(Database issue):D623\u2013D628. https:\/\/doi.org\/10.1093\/nar\/gkn698","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1676_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"1676_CR18","doi-asserted-by":"publisher","first-page":"D691","DOI":"10.1093\/nar\/gkq1018","volume":"39","author":"D Croft","year":"2011","unstructured":"Croft D, O'Kelly G, Wu G, Haw R, Gillespie M, Matthews L et al (2011) Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res 39(Database issue):D691\u2013D697. https:\/\/doi.org\/10.1093\/nar\/gkq1018","journal-title":"Nucleic Acids Res"},{"key":"1676_CR19","unstructured":"Biocarta. http:\/\/cgap.nci.nih.gov\/Pathways\/BioCarta_Pathways Accessed 2019."},{"key":"1676_CR20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","volume":"16","author":"H Heberle","year":"2015","unstructured":"Heberle H, Meirelles GV, da Silva FR, Telles GP, Minghim R (2015) InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC Bioinformatics 16:169. https:\/\/doi.org\/10.1186\/s12859-015-0611-3","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"1676_CR21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s12859-016-1281-5","volume":"17","author":"F Lam","year":"2016","unstructured":"Lam F, Lalansingh CM, Babaran HE, Wang Z, Prokopec SD, Fox NS et al (2016) VennDiagramWeb: a web application for the generation of highly customizable Venn and Euler diagrams. BMC Bioinformatics. 17(1):401. https:\/\/doi.org\/10.1186\/s12859-016-1281-5","journal-title":"BMC Bioinformatics."},{"key":"1676_CR22","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neurobiolaging.2017.11.007","volume":"63","author":"R Akhter","year":"2018","unstructured":"Akhter R, Shao Y, Shaw M, Formica S, Khrestian M, Leverenz JB et al (2018) Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer\u2019s disease. Neurobiol Aging 63:110\u2013119","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1676_CR23","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.1038\/s41598-018-22701-2","volume":"8","author":"A Annese","year":"2018","unstructured":"Annese A, Manzari C, Lionetti C, Picardi E, Horner DS, Chiara M et al (2018) Whole transcriptome profiling of late-onset Alzheimer\u2019s disease patients provides insights into the molecular changes involved in the disease. Sci Rep 8(1):4282\u2013018-22701-2","journal-title":"Sci Rep"},{"key":"1676_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fnagi.2018.00041","volume":"10","author":"S Kumar","year":"2018","unstructured":"Kumar S, Reddy PH (2018) MicroRNA-455-3p as a potential biomarker for Alzheimer\u2019s disease: an update. Front Aging Neurosci 10:41","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"1676_CR25","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s10571-017-0572-3","volume":"38","author":"AI Pogue","year":"2018","unstructured":"Pogue AI, Lukiw WJ (2018) Up-regulated pro-inflammatory microRNAs (miRNAs) in Alzheimer\u2019s disease (AD) and age-related macular degeneration (AMD). Cell Mol Neurobiol 38(5):1021\u20131031","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"1676_CR26","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3233\/JAD-170828","volume":"63","author":"J Zumkehr","year":"2018","unstructured":"Zumkehr J, Rodriguez-Ortiz CJ, Medeiros R, Kitazawa M (2018) Inflammatory cytokine, IL-1beta, regulates glial glutamate transporter via microRNA-181a in vitro. J Alzheimers Dis 63(3):965\u2013975","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1676_CR27","doi-asserted-by":"publisher","first-page":"10-017-0414-z","DOI":"10.1186\/s40478-017-0414-z","volume":"5","author":"N Hara","year":"2017","unstructured":"Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K et al (2017) Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer\u2019s disease. Acta Neuropathol Commun 5(1):10-017-0414-z","journal-title":"Acta Neuropathol Commun"},{"issue":"19","key":"1676_CR28","doi-asserted-by":"publisher","first-page":"3808","DOI":"10.1093\/hmg\/ddx267","volume":"26","author":"S Kumar","year":"2017","unstructured":"Kumar S, Vijayan M, Reddy PH (2017) MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer\u2019s disease. Hum Mol Genet 26(19):3808\u20133822","journal-title":"Hum Mol Genet"},{"key":"1676_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neulet.2017.09.043","volume":"661","author":"X Ma","year":"2017","unstructured":"Ma X, Liu L, Meng J (2017) MicroRNA-125b promotes neurons cell apoptosis and tau phosphorylation in Alzheimer\u2019s disease. Neurosci Lett 661:57\u201362","journal-title":"Neurosci Lett"},{"issue":"6","key":"1676_CR30","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1007\/s12035-016-0002-4","volume":"54","author":"S Moncini","year":"2017","unstructured":"Moncini S, Lunghi M, Valmadre A, Grasso M, Vescovo VD, Riva P et al (2017) The miR-15\/107 family of microRNA genes regulates CDK5R1\/p35 with implications for Alzheimer\u2019s disease pathogenesis. Mol Neurobiol 54(6):4329\u20134342","journal-title":"Mol Neurobiol"},{"issue":"167","key":"1676_CR31","first-page":"e1","volume":"50","author":"S Pichler","year":"2017","unstructured":"Pichler S, Gu W, Hartl D, Gasparoni G, Leidinger P, Keller A et al (2017) The miRNome of Alzheimer\u2019s disease: consistent downregulation of the miR-132\/212 cluster. Neurobiol Aging 50(167):e1\u2013e10","journal-title":"Neurobiol Aging"},{"issue":"9","key":"1676_CR32","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.2174\/1567205013666160314150348","volume":"13","author":"H Jesko","year":"2016","unstructured":"Jesko H, Wilkaniec A, Cieslik M, Hilgier W, Gassowska M, Lukiw WJ et al (2016) Altered arginine metabolism in cells transfected with human wild-type beta amyloid precursor protein (beta APP). Curr Alzheimer Res 13(9):1030\u20131039","journal-title":"Curr Alzheimer Res"},{"key":"1676_CR33","doi-asserted-by":"publisher","first-page":"20364","DOI":"10.1038\/srep20364","volume":"6","author":"J Moon","year":"2016","unstructured":"Moon J, Lee ST, Kong IG, Byun JI, Sunwoo JS, Shin JW et al (2016) Early diagnosis of Alzheimer\u2019s disease from elevated olfactory mucosal miR-206 level. Sci Rep 6:20364","journal-title":"Sci Rep"},{"key":"1676_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/genes7120116","volume":"7","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Alexandrov PN, Jaber V, Lukiw WJ (2016) Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer\u2019s disease (AD) is linked to deficits in a natural circular miRNA-7 sponge (circRNA; ciRS-7). Genes. 7:12. https:\/\/doi.org\/10.3390\/genes7120116","journal-title":"Genes."},{"issue":"Pt 3","key":"1676_CR35","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/brain\/awv383","volume":"139","author":"QB Zhu","year":"2016","unstructured":"Zhu QB, Unmehopa U, Bossers K, Hu YT, Verwer R, Balesar R et al (2016) MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer\u2019s disease. Brain 139(Pt 3):908\u2013921","journal-title":"Brain"},{"issue":"2","key":"1676_CR36","first-page":"1565","volume":"8","author":"X Lei","year":"2015","unstructured":"Lei X, Lei L, Zhang Z, Cheng Y (2015) Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer\u2019s disease. Int J Clin Exp Pathol 8(2):1565\u20131574","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"1676_CR37","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1172\/JCI78421","volume":"125","author":"I Santa-Maria","year":"2015","unstructured":"Santa-Maria I, Alaniz ME, Renwick N, Cela C, Fulga TA, Vactor DV et al (2015) Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. J Clin Invest 125(2):681\u2013686","journal-title":"J Clin Invest"},{"issue":"23","key":"1676_CR38","doi-asserted-by":"publisher","first-page":"6721","DOI":"10.1093\/hmg\/ddv377","volume":"24","author":"PY Smith","year":"2015","unstructured":"Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C et al (2015) miR-132\/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet 24(23):6721\u20136735","journal-title":"Hum Mol Genet"},{"key":"1676_CR39","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fnins.2015.00430","volume":"9","author":"RB Weinberg","year":"2015","unstructured":"Weinberg RB, Mufson EJ, Counts SE (2015) Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment. Front Neurosci 9:430","journal-title":"Front Neurosci"},{"issue":"15","key":"1676_CR40","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.15252\/embj.201387576","volume":"33","author":"J Banzhaf-Strathmann","year":"2014","unstructured":"Banzhaf-Strathmann J, Benito E, May S, Arzberger T, Tahirovic S, Kretzschmar H et al (2014) MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer\u2019s disease. EMBO J 33(15):1667\u20131680","journal-title":"EMBO J"},{"issue":"8","key":"1676_CR41","doi-asserted-by":"publisher","first-page":"5184","DOI":"10.1074\/jbc.M113.518241","volume":"289","author":"JM Long","year":"2014","unstructured":"Long JM, Ray B, Lahiri DK (2014) MicroRNA-339-5p down-regulates protein expression of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. J Biol Chem 289(8):5184\u20135198","journal-title":"J Biol Chem"},{"issue":"1","key":"1676_CR42","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","volume":"35","author":"M Muller","year":"2014","unstructured":"Muller M, Kuiperij HB, Claassen JA, Kusters B, Verbeek MM (2014) MicroRNAs in Alzheimer\u2019s disease: differential expression in hippocampus and cell-free cerebrospinal fluid. Neurobiol Aging 35(1):152\u2013158","journal-title":"Neurobiol Aging"},{"issue":"37","key":"1676_CR43","doi-asserted-by":"publisher","first-page":"14645","DOI":"10.1523\/JNEUROSCI.1327-13.2013","volume":"33","author":"S Absalon","year":"2013","unstructured":"Absalon S, Kochanek DM, Raghavan V, Krichevsky AM (2013) MiR-26b, upregulated in Alzheimer\u2019s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 33(37):14645\u201314659","journal-title":"J Neurosci"},{"issue":"2","key":"1676_CR44","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3233\/JAD-122350","volume":"35","author":"SS Hebert","year":"2013","unstructured":"Hebert SS, Wang W-X, Zhu Q, Nelson PT (2013) A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer\u2019s disease, dementia with Lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimers Dis 35(2):335\u2013348","journal-title":"J Alzheimers Dis"},{"issue":"10","key":"1676_CR45","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/emmm.201201974","volume":"5","author":"P Lau","year":"2013","unstructured":"Lau P, Bossers K, Janky RS, Salta E, Frigerio CS, Barbash S et al (2013) Alteration of the microRNA network during the progression of Alzheimer\u2019s disease. EMBO Mol Med 5(10):1613\u20131634","journal-title":"EMBO Mol Med"},{"issue":"15","key":"1676_CR46","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1093\/hmg\/ddt164","volume":"22","author":"HK Wong","year":"2013","unstructured":"Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C et al (2013) De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer\u2019s disease. Hum Mol Genet 22(15):3077\u20133092. https:\/\/doi.org\/10.1093\/hmg\/ddt164","journal-title":"Hum Mol Genet"},{"issue":"2","key":"1676_CR47","doi-asserted-by":"publisher","first-page":"e55276","DOI":"10.1371\/journal.pone.0055276","volume":"8","author":"H Yan","year":"2013","unstructured":"Yan H, Xu T, Zhao H, Lee KC, Wang HY, Zhang Y (2013) Isoflurane increases neuronal cell death vulnerability by downregulating miR-214. PLoS One 8(2):e55276","journal-title":"PLoS One"},{"issue":"6","key":"1676_CR48","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/WNR.0b013e32835fb6b0","volume":"24","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Bhattacharjee S, Jones BM, Dua P, Alexandrov PN, Hill JM et al (2013) Regulation of TREM2 expression by an NF-small ka, CyrillicB-sensitive miRNA-34a. Neuroreport. 24(6):318\u2013323","journal-title":"Neuroreport."},{"issue":"4","key":"1676_CR49","first-page":"365","volume":"3","author":"PN Alexandrov","year":"2012","unstructured":"Alexandrov PN, Dua P, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ (2012) MicroRNA (miRNA) speciation in Alzheimer\u2019s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int J Biochem Mol Biol 3(4):365\u2013373","journal-title":"Int J Biochem Mol Biol"},{"issue":"2","key":"1676_CR50","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ana.23588","volume":"72","author":"ST Lee","year":"2012","unstructured":"Lee ST, Chu K, Jung KH, Kim JH, Huh JY, Yoon H et al (2012) miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol 72(2):269\u2013277","journal-title":"Ann Neurol"},{"issue":"10","key":"1676_CR51","first-page":"621","volume":"23","author":"WJ Lukiw","year":"2012","unstructured":"Lukiw WJ, Alexandrov PN, Zhao Y, Hill JM, Bhattacharjee S (2012) Spreading of Alzheimer\u2019s disease inflammatory signaling through soluble micro-RNA. Neuroreport. 23(10):621\u2013626","journal-title":"Neuroreport."},{"issue":"52","key":"1676_CR52","doi-asserted-by":"publisher","first-page":"21093","DOI":"10.1073\/pnas.1112061109","volume":"108","author":"M Agostini","year":"2011","unstructured":"Agostini M, Tucci P, Killick R, Candi E, Sayan BS, di Val Cervo PR et al (2011) Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A 108(52):21093\u201321098","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1676_CR53","first-page":"156","volume":"2","author":"D Culpan","year":"2011","unstructured":"Culpan D, Kehoe PG, Love S (2011) Tumour necrosis factor-alpha (TNF-alpha) and miRNA expression in frontal and temporal neocortex in Alzheimer\u2019s disease and the effect of TNF-alpha on miRNA expression in vitro. Int J Mol Epidemiol Genet 2(2):156\u2013162","journal-title":"Int J Mol Epidemiol Genet"},{"issue":"41","key":"1676_CR54","doi-asserted-by":"publisher","first-page":"14820","DOI":"10.1523\/JNEUROSCI.3883-11.2011","volume":"31","author":"H Geekiyanage","year":"2011","unstructured":"Geekiyanage H, Chan C (2011) MicroRNA-137\/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer\u2019s disease. J Neurosci 31(41):14820\u201314830","journal-title":"J Neurosci"},{"issue":"20","key":"1676_CR55","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.1038\/emboj.2011.327","volume":"30","author":"A Zovoilis","year":"2011","unstructured":"Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P et al (2011) microRNA-34c is a novel target to treat dementias. EMBO J 30(20):4299\u20134308","journal-title":"EMBO J"},{"issue":"50","key":"1676_CR56","doi-asserted-by":"publisher","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","volume":"285","author":"JG Cui","year":"2010","unstructured":"Cui JG, Li YY, Zhao Y, Bhattacharjee S, Lukiw WJ (2010) Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. J Biol Chem 285(50):38951\u201338960","journal-title":"J Biol Chem"},{"key":"1676_CR57","doi-asserted-by":"crossref","unstructured":"Faghihi MA, Zhang M, Huang J, Modarresi F, der Brug MPV, Nalls MA et al (2010) Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol 11(5) R56\u20132010-11-5-r56","DOI":"10.1186\/gb-2010-11-5-r56"},{"issue":"2","key":"1676_CR58","doi-asserted-by":"publisher","first-page":"e8898","DOI":"10.1371\/journal.pone.0008898","volume":"5","author":"J Nunez-Iglesias","year":"2010","unstructured":"Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ (2010) Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer\u2019s disease cortex reveals altered miRNA regulation. PLoS One 5(2):e8898","journal-title":"PLoS One"},{"issue":"2","key":"1676_CR59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","volume":"459","author":"P Sethi","year":"2009","unstructured":"Sethi P, Lukiw WJ (2009) Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer\u2019s disease temporal lobe neocortex. Neurosci Lett 459(2):100\u2013104","journal-title":"Neurosci Lett"},{"issue":"1","key":"1676_CR60","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3233\/JAD-2008-14103","volume":"14","author":"JP Cogswell","year":"2008","unstructured":"Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B et al (2008) Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14(1):27\u201341","journal-title":"J Alzheimers Dis"},{"issue":"46","key":"1676_CR61","doi-asserted-by":"publisher","first-page":"31315","DOI":"10.1074\/jbc.M805371200","volume":"283","author":"WJ Lukiw","year":"2008","unstructured":"Lukiw WJ, Zhao Y, Cui JG (2008) An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem 283(46):31315\u201331322","journal-title":"J Biol Chem"},{"issue":"5","key":"1676_CR62","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1523\/JNEUROSCI.5065-07.2008","volume":"28","author":"WX Wang","year":"2008","unstructured":"Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q et al (2008) The expression of microRNA miR-107 decreases early in Alzheimer\u2019s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28(5):1213\u20131223","journal-title":"J Neurosci"},{"issue":"3","key":"1676_CR63","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/WNR.0b013e3280148e8b","volume":"18","author":"WJ Lukiw","year":"2007","unstructured":"Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer\u2019s disease hippocampus. Neuroreport. 18(3):297\u2013300","journal-title":"Neuroreport."},{"issue":"2","key":"1676_CR64","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","volume":"235","author":"H Geekiyanage","year":"2012","unstructured":"Geekiyanage H, Jicha GA, Nelson PT, Chan C (2012) Blood serum miRNA: non-invasive biomarkers for Alzheimer\u2019s disease. Exp Neurol 235(2):491\u2013496","journal-title":"Exp Neurol"},{"issue":"5","key":"1676_CR65","doi-asserted-by":"publisher","first-page":"e0197329","DOI":"10.1371\/journal.pone.0197329","volume":"13","author":"J Denk","year":"2018","unstructured":"Denk J, Oberhauser F, Kornhuber J, Wiltfang J, Fassbender K, Schroeter ML et al (2018) Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls. PLoS One 13(5):e0197329","journal-title":"PLoS One"},{"issue":"7","key":"1676_CR66","doi-asserted-by":"publisher","first-page":"e0200602","DOI":"10.1371\/journal.pone.0200602","volume":"13","author":"K Derkow","year":"2018","unstructured":"Derkow K, Rossling R, Schipke C, Kruger C, Bauer J, Fahling M et al (2018) Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer\u2019s disease. PLoS One 13(7):e0200602","journal-title":"PLoS One"},{"issue":"3","key":"1676_CR67","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3233\/JAD-180201","volume":"64","author":"IHK Dias","year":"2018","unstructured":"Dias IHK, Brown CL, Shabir K, Polidori MC, Griffiths HR (2018) miRNA 933 expression by endothelial cells is increased by 27-hydroxycholesterol and is more prevalent in plasma from dementia patients. J Alzheimers Dis 64(3):1009\u20131017","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1676_CR68","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3233\/JAD-170592","volume":"61","author":"PR Manzine","year":"2018","unstructured":"Manzine PR, Pelucchi S, Horst MA, Vale FAC, Pavarini SCI, Audano M et al (2018) MicroRNA 221 targets ADAM10 mRNA and is downregulated in Alzheimer\u2019s disease. J Alzheimers Dis 61(1):113\u2013123","journal-title":"J Alzheimers Dis"},{"key":"1676_CR69","doi-asserted-by":"crossref","unstructured":"McKeever PM, Schneider R, Taghdiri F, Weichert A, Multani N, Brown RA et al (2018) MicroRNA expression levels are altered in the cerebrospinal fluid of patients with young-onset Alzheimer\u2019s disease. Mol Neurobiol","DOI":"10.1007\/s12035-018-1032-x"},{"key":"1676_CR70","doi-asserted-by":"crossref","unstructured":"Piscopo P, Grasso M, Puopolo M, D'Acunto E, Talarico G, Crestini A et al (2018) Circulating miR-127-3p as a potential biomarker for differential diagnosis in frontotemporal dementia. J Alzheimers Dis","DOI":"10.3233\/JAD-180364"},{"issue":"2","key":"1676_CR71","first-page":"87","volume":"31","author":"TT Yang","year":"2018","unstructured":"Yang TT, Liu CG, Gao SC, Zhang Y, Wang PC (2018) The serum exosome derived microRNA-135a, \u2212193b, and \u2212384 were potential Alzheimer\u2019s disease biomarkers. Biomed Environ Sci 31(2):87\u201396","journal-title":"Biomed Environ Sci"},{"issue":"7","key":"1676_CR72","doi-asserted-by":"publisher","first-page":"5550","DOI":"10.1007\/s12035-016-0088-8","volume":"54","author":"M Cosin-Tomas","year":"2017","unstructured":"Cosin-Tomas M, Antonell A, Llado A, Alcolea D, Fortea J, Ezquerra M et al (2017) Plasma miR-34a-5p and miR-545-3p as early biomarkers of Alzheimer\u2019s disease: potential and limitations. Mol Neurobiol 54(7):5550\u20135562","journal-title":"Mol Neurobiol"},{"issue":"9","key":"1676_CR73","doi-asserted-by":"publisher","first-page":"6647","DOI":"10.1007\/s12035-016-0106-x","volume":"54","author":"A Dangla-Valls","year":"2017","unstructured":"Dangla-Valls A, Molinuevo JL, Altirriba J, Sanchez-Valle R, Alcolea D, Fortea J et al (2017) CSF microRNA profiling in Alzheimer\u2019s disease: a screening and validation study. Mol Neurobiol 54(9):6647\u20136654","journal-title":"Mol Neurobiol"},{"issue":"4","key":"1676_CR74","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3233\/JAD-170343","volume":"60","author":"R Guo","year":"2017","unstructured":"Guo R, Fan G, Zhang J, Wu C, Du Y, Ye H et al (2017) A 9-microRNA signature in serum serves as a noninvasive biomarker in early diagnosis of Alzheimer\u2019s disease. J Alzheimers Dis 60(4):1365\u20131377","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"1676_CR75","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3233\/JAD-160835","volume":"55","author":"TA Lusardi","year":"2017","unstructured":"Lusardi TA, Phillips JI, Wiedrick JT, Harrington CA, Lind B, Lapidus JA et al (2017) MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer\u2019s disease. J Alzheimers Dis 55(3):1223\u20131233","journal-title":"J Alzheimers Dis"},{"issue":"10","key":"1676_CR76","doi-asserted-by":"publisher","first-page":"16122","DOI":"10.18632\/oncotarget.15109","volume":"8","author":"S Nagaraj","year":"2017","unstructured":"Nagaraj S, Laskowska-Kaszub K, Debski KJ, Wojsiat J, Dabrowski M, Gabryelewicz T et al (2017) Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer\u2019s disease patients from non-demented subjects. Oncotarget. 8(10):16122\u201316143","journal-title":"Oncotarget."},{"issue":"2","key":"1676_CR77","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3233\/JAD-161179","volume":"57","author":"J Riancho","year":"2017","unstructured":"Riancho J, Vazquez-Higuera JL, Pozueta A, Lage C, Kazimierczak M, Bravo M et al (2017) MicroRNA profile in patients with Alzheimer\u2019s disease: analysis of miR-9-5p and miR-598 in raw and exosome enriched cerebrospinal fluid samples. J Alzheimers Dis 57(2):483\u2013491","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"1676_CR78","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1620\/tjem.242.129","volume":"242","author":"Y Wu","year":"2017","unstructured":"Wu Y, Xu J, Cheng J, Jiao D, Zhou C, Dai Y et al (2017) Lower serum levels of miR-29c-3p and miR-19b-3p as biomarkers for Alzheimer\u2019s disease. Tohoku J Exp Med 242(2):129\u2013136","journal-title":"Tohoku J Exp Med"},{"issue":"4","key":"1676_CR79","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/cbf.3184","volume":"34","author":"LH Jia","year":"2016","unstructured":"Jia LH, Liu YN (2016) Downregulated serum miR-223 servers as biomarker in Alzheimer\u2019s disease. Cell Biochem Funct 34(4):233\u2013237","journal-title":"Cell Biochem Funct"},{"issue":"5","key":"1676_CR80","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jalz.2015.12.012","volume":"12","author":"A Keller","year":"2016","unstructured":"Keller A, Backes C, Haas J, Leidinger P, Maetzler W, Deuschle C et al (2016) Validating Alzheimer\u2019s disease micro RNAs using next-generation sequencing. Alzheimers Dement 12(5):565\u2013576","journal-title":"Alzheimers Dement"},{"issue":"5","key":"1676_CR81","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1007\/s12035-015-9156-8","volume":"53","author":"M Muller","year":"2016","unstructured":"Muller M, Jakel L, Bruinsma IB, Claassen JA, Kuiperij HB, Verbeek MM (2016) MicroRNA-29a is a candidate biomarker for Alzheimer\u2019s disease in cell-free cerebrospinal fluid. Mol Neurobiol 53(5):2894\u20132899","journal-title":"Mol Neurobiol"},{"issue":"4","key":"1676_CR82","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3233\/JAD-160038","volume":"52","author":"M Muller","year":"2016","unstructured":"Muller M, Kuiperij HB, Versleijen AA, Chiasserini D, Farotti L, Baschieri F et al (2016) Validation of microRNAs in cerebrospinal fluid as biomarkers for different forms of dementia in a multicenter study. J Alzheimers Dis 52(4):1321\u20131333","journal-title":"J Alzheimers Dis"},{"key":"1676_CR83","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fncel.2016.00051","volume":"10","author":"M Ragusa","year":"2016","unstructured":"Ragusa M, Bosco P, Tamburello L, Barbagallo C, Condorelli AG, Tornitore M et al (2016) miRNAs plasma profiles in vascular dementia: biomolecular data and biomedical implications. Front Cell Neurosci 10:51","journal-title":"Front Cell Neurosci"},{"issue":"8","key":"1676_CR84","doi-asserted-by":"publisher","first-page":"5772","DOI":"10.1007\/s12035-015-9484-8","volume":"53","author":"RJ Ren","year":"2016","unstructured":"Ren RJ, Zhang YF, Dammer EB, Zhou Y, Wang LL, Liu XH et al (2016) Peripheral blood microRNA expression profiles in Alzheimer\u2019s disease: screening, validation, association with clinical phenotype and implications for molecular mechanism. Mol Neurobiol 53(8):5772\u20135781","journal-title":"Mol Neurobiol"},{"issue":"2","key":"1676_CR85","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.3892\/mmr.2016.5369","volume":"14","author":"H Xing","year":"2016","unstructured":"Xing H, Guo S, Zhang Y, Zheng Z, Wang H (2016) Upregulation of microRNA-206 enhances lipopolysaccharide-induced inflammation and release of amyloid-beta by targeting insulin-like growth factor 1 in microglia. Mol Med Rep 14(2):1357\u20131364","journal-title":"Mol Med Rep"},{"issue":"8","key":"1676_CR86","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1089\/omi.2016.0099","volume":"20","author":"SG Yilmaz","year":"2016","unstructured":"Yilmaz SG, Erdal ME, Ozge AA, Sungur MA (2016) Can peripheral microRNA expression data serve as epigenomic (upstream) biomarkers of Alzheimer\u2019s disease? OMICS 20(8):456\u2013461","journal-title":"OMICS"},{"key":"1676_CR87","doi-asserted-by":"publisher","first-page":"24566","DOI":"10.1038\/srep24566","volume":"6","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Liu C, Wang J, Li Q, Ping H, Gao S et al (2016) MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity in APPswe\/PS1dE9 mice. Sci Rep 6:24566","journal-title":"Sci Rep"},{"issue":"2","key":"1676_CR88","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3892\/etm.2016.3366","volume":"12","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Xing H, Guo S, Zheng Z, Wang H, Xu D (2016) MicroRNA-135b has a neuroprotective role via targeting of beta-site APP-cleaving enzyme 1. Exp Ther Med 12(2):809\u2013814","journal-title":"Exp Ther Med"},{"issue":"10","key":"1676_CR89","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/mp.2014.127","volume":"20","author":"L Cheng","year":"2015","unstructured":"Cheng L, Doecke JD, Sharples RA, Villemagne VL, Fowler CJ, Rembach A et al (2015) Prognostic serum miRNA biomarkers associated with Alzheimer\u2019s disease shows concordance with neuropsychological and neuroimaging assessment. Mol Psychiatry 20(10):1188\u20131196","journal-title":"Mol Psychiatry"},{"issue":"5","key":"1676_CR90","doi-asserted-by":"publisher","first-page":"e0126423","DOI":"10.1371\/journal.pone.0126423","volume":"10","author":"J Denk","year":"2015","unstructured":"Denk J, Boelmans K, Siegismund C, Lassner D, Arlt S, Jahn H (2015) MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer\u2019s disease. PLoS One 10(5):e0126423","journal-title":"PLoS One"},{"key":"1676_CR91","first-page":"625659","volume":"2015","author":"H Dong","year":"2015","unstructured":"Dong H, Li J, Huang L, Chen X, Li D, Wang T et al (2015) Serum microRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer\u2019s disease. Dis Markers 2015:625659","journal-title":"Dis Markers"},{"key":"1676_CR92","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.dadm.2015.11.004","volume":"3","author":"JR Guedes","year":"2015","unstructured":"Guedes JR, Santana I, Cunha C, Duro D, Almeida MR, Cardoso AM et al (2015) MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer\u2019s disease. Alzheimers Dement (Amst) 3:7\u201317","journal-title":"Alzheimers Dement (Amst)"},{"issue":"35","key":"1676_CR93","doi-asserted-by":"publisher","first-page":"37043","DOI":"10.18632\/oncotarget.6158","volume":"6","author":"Y Gui","year":"2015","unstructured":"Gui Y, Liu H, Zhang L, Lv W, Hu X (2015) Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget. 6(35):37043\u201337053","journal-title":"Oncotarget."},{"issue":"1","key":"1676_CR94","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3233\/JAD-140075","volume":"47","author":"AC van Harten","year":"2015","unstructured":"van Harten AC, Mulders J, Scheltens P, van der Flier WM, Oudejans CB (2015) Differential expression of microRNA in cerebrospinal fluid as a potential novel biomarker for Alzheimer\u2019s disease. J Alzheimers Dis 47(1):243\u2013252","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"1676_CR95","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4088\/JCP.13m08812","volume":"76","author":"T Wang","year":"2015","unstructured":"Wang T, Chen K, Li H, Dong S, Su N, Liu Y et al (2015) The feasibility of utilizing plasma MiRNA107 and BACE1 messenger RNA gene expression for clinical diagnosis of amnestic mild cognitive impairment. J Clin Psychiatry 76(2):135\u2013141","journal-title":"J Clin Psychiatry"},{"issue":"2","key":"1676_CR96","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.3892\/mmr.2015.3728","volume":"12","author":"G Yang","year":"2015","unstructured":"Yang G, Song Y, Zhou X, Deng Y, Liu T, Weng G et al (2015) MicroRNA-29c targets beta-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo. Mol Med Rep 12(2):3081\u20133088","journal-title":"Mol Med Rep"},{"issue":"3","key":"1676_CR97","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3892\/etm.2015.2179","volume":"9","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Li C, Sun A, Wang Y, Zhou S (2015) Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer\u2019s disease. Exp Ther Med 9(3):1013\u20131017","journal-title":"Exp Ther Med"},{"key":"1676_CR98","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnmol.2014.00002","volume":"7","author":"S Bhatnagar","year":"2014","unstructured":"Bhatnagar S, Chertkow H, Schipper HM, Yuan Z, Shetty V, Jenkins S et al (2014) Increased microRNA-34c abundance in Alzheimer\u2019s disease circulating blood plasma. Front Mol Neurosci 7:2","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"1676_CR99","doi-asserted-by":"publisher","first-page":"e94839","DOI":"10.1371\/journal.pone.0094839","volume":"9","author":"K Burgos","year":"2014","unstructured":"Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T et al (2014) Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer\u2019s and Parkinson\u2019s diseases correlate with disease status and features of pathology. PLoS One 9(5):e94839","journal-title":"PLoS One"},{"issue":"2","key":"1676_CR100","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3233\/JAD-130932","volume":"39","author":"T Kiko","year":"2014","unstructured":"Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T (2014) MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer\u2019s disease. J Alzheimers Dis 39(2):253\u2013259","journal-title":"J Alzheimers Dis"},{"key":"1676_CR101","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainres.2014.04.026","volume":"1583","author":"C geng Liu","year":"2014","unstructured":"geng Liu C, ling Wang J, Li L, xiang Xue L, qi Zhang Y, chang Wang P (2014) MicroRNA-135a and-200b, potential biomarkers for Alzheimer\u2019s disease, regulate beta secretase and amyloid precursor protein. Brain Res 1583:55\u201364","journal-title":"Brain Res"},{"issue":"1\u20132","key":"1676_CR102","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jns.2013.10.002","volume":"336","author":"L Tan","year":"2014","unstructured":"Tan L, Yu JT, Liu QY, Tan MS, Zhang W, Hu N et al (2014) Circulating miR-125b as a biomarker of Alzheimer\u2019s disease. J Neurol Sci 336(1\u20132):52\u201356","journal-title":"J Neurol Sci"},{"issue":"4","key":"1676_CR103","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3233\/JAD-132144","volume":"40","author":"L Tan","year":"2014","unstructured":"Tan L, Yu JT, Tan MS, Liu QY, Wang HF, Zhang W et al (2014) Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer\u2019s disease. J Alzheimers Dis 40(4):1017\u20131027","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"1676_CR104","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neurobiolaging.2013.08.003","volume":"35","author":"R Tiribuzi","year":"2014","unstructured":"Tiribuzi R, Crispoltoni L, Porcellati S, Lullo MD, Florenzano F, Pirro M et al (2014) miR128 up-regulation correlates with impaired amyloid beta(1-42) degradation in monocytes from patients with sporadic Alzheimer\u2019s disease. Neurobiol Aging 35(2):345\u2013356","journal-title":"Neurobiol Aging"},{"issue":"5","key":"1676_CR105","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3109\/1354750X.2013.814073","volume":"18","author":"LM Bekris","year":"2013","unstructured":"Bekris LM, Lutz F, Montine TJ, Yu CE, Tsuang D, Peskind ER et al (2013) MicroRNA in Alzheimer\u2019s disease: an exploratory study in brain, cerebrospinal fluid and plasma. Biomarkers. 18(5):455\u2013466. https:\/\/doi.org\/10.3109\/1354750X.2013.814073","journal-title":"Biomarkers."},{"issue":"24","key":"1676_CR106","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1212\/01.wnl.0000437306.37850.22","volume":"81","author":"CS Frigerio","year":"2013","unstructured":"Frigerio CS, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R et al (2013) Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology. 81(24):2103\u20132106","journal-title":"Neurology."},{"issue":"7","key":"1676_CR107","doi-asserted-by":"publisher","first-page":"e69807","DOI":"10.1371\/journal.pone.0069807","volume":"8","author":"P Kumar","year":"2013","unstructured":"Kumar P, Dezso Z, MacKenzie C, Oestreicher J, Agoulnik S, Byrne M et al (2013) Circulating miRNA biomarkers for Alzheimer\u2019s disease. PLoS One 8(7):e69807","journal-title":"PLoS One"},{"issue":"7","key":"1676_CR108","doi-asserted-by":"publisher","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","volume":"14","author":"P Leidinger","year":"2013","unstructured":"Leidinger P, Backes C, Deutscher S, Schmitt K, Mueller SC, Frese K et al (2013) A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol 14(7):R78","journal-title":"Genome Biol"},{"issue":"6","key":"1676_CR109","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nn.3113","volume":"15","author":"SM Lehmann","year":"2012","unstructured":"Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, Baumgart J et al (2012) An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 15(6):827\u2013835","journal-title":"Nat Neurosci"},{"issue":"3","key":"1676_CR110","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1089\/rej.2010.1123","volume":"14","author":"C Villa","year":"2011","unstructured":"Villa C, Fenoglio C, Riz MD, Clerici F, Marcone A, Benussi L et al (2011) Role of hnRNP-A1 and miR-590-3p in neuronal death: genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration. Rejuvenation Res 14(3):275\u2013281","journal-title":"Rejuvenation Res"},{"key":"1676_CR111","first-page":"263","volume":"1","author":"HM Schipper","year":"2007","unstructured":"Schipper HM, Maes OC, Chertkow HM, Wang E (2007) MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regul Syst Biol 1:263\u2013274","journal-title":"Gene Regul Syst Biol"},{"issue":"12","key":"1676_CR112","doi-asserted-by":"publisher","first-page":"925","DOI":"10.18632\/aging.100624","volume":"5","author":"KS Sheinerman","year":"2013","unstructured":"Sheinerman KS, Tsivinsky VG, Abdullah L, Crawford F, Umansky SR (2013) Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. Aging (Albany NY) 5(12):925\u2013938. https:\/\/doi.org\/10.18632\/aging.100624","journal-title":"Aging (Albany NY)"},{"key":"1676_CR113","doi-asserted-by":"publisher","unstructured":"Swarbrick S, Wragg N, Ghosh S, Stolzing A (2019) Systematic review of miRNA as biomarkers in Alzheimer\u2019s disease. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-019-1500-y","DOI":"10.1007\/s12035-019-1500-y"},{"key":"1676_CR114","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.clinbiochem.2018.05.020","volume":"58","author":"PD Fransquet","year":"2018","unstructured":"Fransquet PD, Ryan J (2018) Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer\u2019s disease. Clin Biochem 58:5\u201314. https:\/\/doi.org\/10.1016\/j.clinbiochem.2018.05.020","journal-title":"Clin Biochem"},{"issue":"6","key":"1676_CR115","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/jnc.12437","volume":"127","author":"JR Dickson","year":"2013","unstructured":"Dickson JR, Kruse C, Montagna DR, Finsen B, Wolfe MS (2013) Alternative polyadenylation and miR-34 family members regulate tau expression. J Neurochem 127(6):739\u2013749. https:\/\/doi.org\/10.1111\/jnc.12437","journal-title":"J Neurochem"},{"issue":"1","key":"1676_CR116","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neulet.2010.03.054","volume":"476","author":"AI Pogue","year":"2010","unstructured":"Pogue AI, Cui JG, Li YY, Zhao Y, Culicchia F, Lukiw WJ (2010) Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neurosci Lett 476(1):18\u201322. https:\/\/doi.org\/10.1016\/j.neulet.2010.03.054","journal-title":"Neurosci Lett"},{"issue":"4","key":"1676_CR117","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1515\/bmc-2016-0014","volume":"7","author":"M Basavaraju","year":"2016","unstructured":"Basavaraju M, de Lencastre A (2016) Alzheimer\u2019s disease: presence and role of microRNAs. Biomol Concepts 7(4):241\u2013252. https:\/\/doi.org\/10.1515\/bmc-2016-0014","journal-title":"Biomol Concepts"},{"key":"1676_CR118","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3389\/fgene.2012.00327","volume":"3","author":"WJ Lukiw","year":"2012","unstructured":"Lukiw WJ, Andreeva TV, Grigorenko AP, Rogaev EI (2012) Studying micro RNA function and dysfunction in Alzheimer\u2019s disease. Front Genet 3:327. https:\/\/doi.org\/10.3389\/fgene.2012.00327","journal-title":"Front Genet"},{"key":"1676_CR119","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0072-9752(07)01223-7","volume":"89","author":"DJ Selkoe","year":"2008","unstructured":"Selkoe DJ (2008) Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer\u2019s disease. Handb Clin Neurol 89:245\u2013260. https:\/\/doi.org\/10.1016\/S0072-9752(07)01223-7","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"1676_CR120","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.semcdb.2003.12.015","volume":"15","author":"M Goedert","year":"2004","unstructured":"Goedert M (2004) Tau protein and neurodegeneration. Semin Cell Dev Biol 15(1):45\u201349","journal-title":"Semin Cell Dev Biol"},{"key":"1676_CR121","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/ncrna5020035","volume":"5","author":"JA Slota","year":"2019","unstructured":"Slota JA, Booth SA (2019) MicroRNAs in neuroinflammation: implications in disease pathogenesis, biomarker discovery and therapeutic applications. Noncoding RNA 5:2. https:\/\/doi.org\/10.3390\/ncrna5020035","journal-title":"Noncoding RNA"},{"issue":"3","key":"1676_CR122","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/1073858417721150","volume":"24","author":"AD Gaudet","year":"2018","unstructured":"Gaudet AD, Fonken LK, Watkins LR, Nelson RJ, Popovich PG (2018) MicroRNAs: roles in regulating neuroinflammation. Neuroscientist. 24(3):221\u2013245. https:\/\/doi.org\/10.1177\/1073858417721150","journal-title":"Neuroscientist."},{"issue":"5","key":"1676_CR123","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","volume":"71","author":"PT Nelson","year":"2012","unstructured":"Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ et al (2012) Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71(5):362\u2013381. https:\/\/doi.org\/10.1097\/NEN.0b013e31825018f7","journal-title":"J Neuropathol Exp Neurol"},{"issue":"52","key":"1676_CR124","doi-asserted-by":"publisher","first-page":"41340","DOI":"10.1074\/jbc.M006219200","volume":"275","author":"K Spittaels","year":"2000","unstructured":"Spittaels K, Van den Haute C, Van Dorpe J, Geerts H, Mercken M, Bruynseels K et al (2000) Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem 275(52):41340\u201341349. https:\/\/doi.org\/10.1074\/jbc.M006219200","journal-title":"J Biol Chem"},{"key":"1676_CR125","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3389\/fphar.2018.00548","volume":"9","author":"B Shal","year":"2018","unstructured":"Shal B, Ding W, Ali H, Kim YS, Khan S (2018) Anti-neuroinflammatory potential of natural products in attenuation of Alzheimer\u2019s disease. Front Pharmacol 9:548. https:\/\/doi.org\/10.3389\/fphar.2018.00548","journal-title":"Front Pharmacol"},{"issue":"42","key":"1676_CR126","doi-asserted-by":"publisher","first-page":"13966","DOI":"10.1523\/JNEUROSCI.3637-10.2010","volume":"30","author":"D Piedrahita","year":"2010","unstructured":"Piedrahita D, Hern\u00e1ndez I, L\u00f3pez-Tob\u00f3n A, Fedorov D, Obara B, Manjunath BS et al (2010) Silencing of CDK5 reduces neurofibrillary tangles in transgenic Alzheimer's mice. J Neurosci 30(42):13966\u201313976","journal-title":"J Neurosci"},{"issue":"2","key":"1676_CR127","first-page":"509","volume":"10","author":"E Masliah","year":"1995","unstructured":"Masliah E (1995) Mechanisms of synaptic dysfunction in Alzheimer\u2019s disease. Histol Histopathol 10(2):509\u2013519","journal-title":"Histol Histopathol"},{"issue":"1","key":"1676_CR128","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1212\/WNL.43.1_Part_1.192","volume":"43","author":"E Masliah","year":"1993","unstructured":"Masliah E, Mallory M, Hansen L, DeTeresa R, Terry RD (1993) Quantitative synaptic alterations in the human neocortex during normal aging. Neurology. 43(1):192\u2013197","journal-title":"Neurology."},{"issue":"7","key":"1676_CR129","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/01.jnen.0000228136.58062.bf","volume":"65","author":"A Nunomura","year":"2006","unstructured":"Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA (2006) Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol 65(7):631\u2013641","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3 Pt 1","key":"1676_CR130","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1212\/WNL.42.3.631","volume":"42","author":"PV Arriagada","year":"1992","unstructured":"Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease. Neurology. 42(3 Pt 1):631\u2013639","journal-title":"Neurology."},{"issue":"8","key":"1676_CR131","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1084\/jem.20160493","volume":"213","author":"M Stanley","year":"2016","unstructured":"Stanley M, Macauley SL, Holtzman DM (2016) Changes in insulin and insulin signaling in Alzheimer\u2019s disease: cause or consequence? J Exp Med 213(8):1375\u20131385. https:\/\/doi.org\/10.1084\/jem.20160493","journal-title":"J Exp Med"},{"key":"1676_CR132","doi-asserted-by":"publisher","unstructured":"de la Monte SM, Tong M, Daiello LA, Ott BR (2019) Early-stage Alzheimer\u2019s disease is associated with simultaneous systemic and central nervous system dysregulation of insulin-linked metabolic pathways. J Alzheimers Dis. https:\/\/doi.org\/10.3233\/JAD-180906","DOI":"10.3233\/JAD-180906"},{"issue":"4","key":"1676_CR133","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1172\/JCI59903","volume":"122","author":"K Talbot","year":"2012","unstructured":"Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A et al (2012) Demonstrated brain insulin resistance in Alzheimer\u2019s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122(4):1316\u20131338. https:\/\/doi.org\/10.1172\/JCI59903","journal-title":"J Clin Invest"},{"issue":"1","key":"1676_CR134","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2165\/11597760-000000000-00000","volume":"72","author":"SM de la Monte","year":"2012","unstructured":"de la Monte SM (2012) Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer\u2019s disease. Drugs. 72(1):49\u201366. https:\/\/doi.org\/10.2165\/11597760-000000000-00000","journal-title":"Drugs."},{"issue":"3","key":"1676_CR135","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3233\/JAD-2005-8304","volume":"8","author":"EJ Rivera","year":"2005","unstructured":"Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM (2005) Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer\u2019s disease: link to brain reductions in acetylcholine. J Alzheimers Dis 8(3):247\u2013268","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"1676_CR136","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1073\/pnas.0308724101","volume":"101","author":"M Schubert","year":"2004","unstructured":"Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D et al (2004) Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 101(9):3100\u20133105. https:\/\/doi.org\/10.1073\/pnas.0308724101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1676_CR137","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2174\/156720507780362137","volume":"4","author":"S Craft","year":"2007","unstructured":"Craft S (2007) Insulin resistance and Alzheimer\u2019s disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 4(2):147\u2013152","journal-title":"Curr Alzheimer Res"},{"issue":"12","key":"1676_CR138","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1016\/j.euroneuro.2014.06.008","volume":"24","author":"SM de la Monte","year":"2014","unstructured":"de la Monte SM (2014) Type 3 diabetes is sporadic Alzheimer\u2019s disease: mini-review. Eur Neuropsychopharmacol 24(12):1954\u20131960. https:\/\/doi.org\/10.1016\/j.euroneuro.2014.06.008","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"1676_CR139","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3233\/JAD-2010-091687","volume":"20","author":"JA Luchsinger","year":"2010","unstructured":"Luchsinger JA (2010) Type 2 diabetes, related conditions, in relation and dementia: an opportunity for prevention? J Alzheimers Dis 20(3):723\u2013736. https:\/\/doi.org\/10.3233\/JAD-2010-091687","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"1676_CR140","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1007\/s00125-009-1536-z","volume":"52","author":"P Newsholme","year":"2009","unstructured":"Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Procopio J, Curi R et al (2009) Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia. 52(12):2489\u20132498. https:\/\/doi.org\/10.1007\/s00125-009-1536-z","journal-title":"Diabetologia."},{"issue":"7","key":"1676_CR141","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1096\/fj.03-0978fje","volume":"18","author":"L Ho","year":"2004","unstructured":"Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z et al (2004) Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer\u2019s disease. FASEB J 18(7):902\u2013904. https:\/\/doi.org\/10.1096\/fj.03-0978fje","journal-title":"FASEB J"},{"issue":"12","key":"1676_CR142","doi-asserted-by":"publisher","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","volume":"187","author":"M Kitazawa","year":"2011","unstructured":"Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V et al (2011) Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer\u2019s disease model. J Immunol 187(12):6539\u20136549. https:\/\/doi.org\/10.4049\/jimmunol.1100620","journal-title":"J Immunol"},{"key":"1676_CR143","first-page":"1","volume":"1","author":"D Kempuraj","year":"2016","unstructured":"Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H et al (2016) Neuroinflammation induces neurodegeneration. J Neurol Neurosurg Spine 1:1","journal-title":"J Neurol Neurosurg Spine"},{"key":"1676_CR144","doi-asserted-by":"publisher","unstructured":"Kirouac L, Rajic AJ, Cribbs DH, Padmanabhan J (2017) Activation of Ras-ERK signaling and GSK-3 by amyloid precursor protein and amyloid beta facilitates neurodegeneration in Alzheimer\u2019s disease. eNeuro. 4(2). https:\/\/doi.org\/10.1523\/ENEURO.0149-16.2017","DOI":"10.1523\/ENEURO.0149-16.2017"},{"issue":"7","key":"1676_CR145","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1590\/0004-282X20150057","volume":"73","author":"TB Bassani","year":"2015","unstructured":"Bassani TB, Vital MA, Rauh LK (2015) Neuroinflammation in the pathophysiology of Parkinson's disease and therapeutic evidence of anti-inflammatory drugs. Arq Neuropsiquiatr 73(7):616\u2013623. https:\/\/doi.org\/10.1590\/0004-282X20150057","journal-title":"Arq Neuropsiquiatr"},{"issue":"12","key":"1676_CR146","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/j.freeradbiomed.2006.08.015","volume":"41","author":"F Longpr\u00e9","year":"2006","unstructured":"Longpr\u00e9 F, Garneau P, Christen Y, Ramassamy C (2006) Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med 41(12):1781\u20131794. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2006.08.015","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1676_CR147","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","volume":"20","author":"LA O\u2019Neill","year":"1997","unstructured":"O\u2019Neill LA, Kaltschmidt C (1997) NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 20(6):252\u2013258","journal-title":"Trends Neurosci"},{"issue":"8","key":"1676_CR148","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.18632\/aging.101925","volume":"11","author":"F Marchegiani","year":"2019","unstructured":"Marchegiani F, Matacchione G, Ramini D, Marcheselli F, Recchioni R, Casoli T et al (2019) Diagnostic performance of new and classic CSF biomarkers in age-related dementias. Aging (Albany NY) 11(8):2420\u20132429. https:\/\/doi.org\/10.18632\/aging.101925","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"1676_CR149","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239\u2013259","journal-title":"Acta Neuropathol"},{"issue":"3","key":"1676_CR150","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189\u2013198","journal-title":"J Psychiatr Res"},{"issue":"3","key":"1676_CR151","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1037\/0021-843X.100.3.308","volume":"100","author":"RO Nelson-Gray","year":"1991","unstructured":"Nelson-Gray RO (1991) DSM-IV: empirical guidelines from psychometrics. J Abnorm Psychol 100(3):308\u2013315","journal-title":"J Abnorm Psychol"},{"issue":"6","key":"1676_CR152","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1515\/cclm-2017-0958","volume":"56","author":"A Kopkova","year":"2018","unstructured":"Kopkova A, Sana J, Fadrus P, Slaby O (2018) Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors. Clin Chem Lab Med 56(6):869\u2013879. https:\/\/doi.org\/10.1515\/cclm-2017-0958","journal-title":"Clin Chem Lab Med"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01676-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-01676-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01676-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T20:03:24Z","timestamp":1610049804000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-01676-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":152,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1676"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-01676-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]},"assertion":[{"value":"1 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}