{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:55Z","timestamp":1786982215146,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Biotechnology, Ministry of Science and Technology"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s12035-019-01680-z","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T17:02:37Z","timestamp":1561654957000},"page":"8420-8434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurotrophic Factors Mediated Activation of Astrocytes Ameliorate Memory Loss by Amyloid Clearance after Transplantation of Lineage Negative Stem Cells"],"prefix":"10.1007","volume":"56","author":[{"given":"P.","family":"Bali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Banik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nehru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-3532","authenticated-orcid":false,"given":"Akshay","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"issue":"3","key":"1680_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1756285609102724","volume":"2","author":"KL Lanctot","year":"2009","unstructured":"Lanctot KL, Rajaram RD, Herrmann N (2009) Therapy for Alzheimer\u2019s disease: how effective are current treatments? Ther Adv Neurol Disord 2(3):163\u2013180. \n                    https:\/\/doi.org\/10.1177\/1756285609102724","journal-title":"Ther Adv Neurol Disord"},{"issue":"5","key":"1680_CR2","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nm1239","volume":"11","author":"MH Tuszynski","year":"2005","unstructured":"Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A et al (2005) A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 11(5):551\u2013555. \n                    https:\/\/doi.org\/10.1038\/nm1239","journal-title":"Nat Med"},{"key":"1680_CR3","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.trci.2018.09.003","volume":"4","author":"SI Liyanage","year":"2018","unstructured":"Liyanage SI, Santos C, Weaver DF (2018) The hidden variables problem in Alzheimer\u2019s disease clinical trial design. Alzheimers Dement (N Y) 4:628\u2013635. \n                    https:\/\/doi.org\/10.1016\/j.trci.2018.09.003","journal-title":"Alzheimers Dement (N Y)"},{"key":"1680_CR4","doi-asserted-by":"publisher","unstructured":"Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Carter A, Casey DC, Charlson FJ, Chen AZ, Coggeshall M (2016) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388(10053):1545\u20131602. \n                    https:\/\/doi.org\/10.1016\/s0140-6736(16)31678-6","DOI":"10.1016\/s0140-6736(16)31678-6"},{"issue":"23","key":"1680_CR5","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1111\/bph.14030","volume":"174","author":"SH Kim","year":"2017","unstructured":"Kim SH, Kandiah N, Hsu JL, Suthisisang C, Udommongkol C, Dash A (2017) Beyond symptomatic effects: potential of donepezil as a neuroprotective agent and disease modifier in. Alzheimer Dis 174(23):4224\u20134232. \n                    https:\/\/doi.org\/10.1111\/bph.14030","journal-title":"Alzheimer Dis"},{"key":"1680_CR6","doi-asserted-by":"publisher","unstructured":"Birks J (2006) Cholinesterase inhibitors for Alzheimer\u2019s disease. Cochrane Database Syst Rev (1):Cd005593. \n                    https:\/\/doi.org\/10.1002\/14651858.cd005593","DOI":"10.1002\/14651858.cd005593"},{"issue":"2","key":"1680_CR7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3233\/jad-170424","volume":"60","author":"T Kishi","year":"2017","unstructured":"Kishi T, Matsunaga S, Oya K, Nomura I, Ikuta T, Iwata N (2017) Memantine for Alzheimer\u2019s disease: an updated systematic review and meta-analysis. J Alzheimers Dis 60(2):401\u2013425. \n                    https:\/\/doi.org\/10.3233\/jad-170424","journal-title":"J Alzheimers Dis"},{"issue":"7631","key":"1680_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nature.2016.21045","volume":"540","author":"A Abbott","year":"2016","unstructured":"Abbott A, Dolgin E (2016) Failed Alzheimer\u2019s trial does not kill leading theory of disease. Nature 540(7631):15\u201316. \n                    https:\/\/doi.org\/10.1038\/nature.2016.21045","journal-title":"Nature"},{"issue":"2","key":"1680_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1586\/eci.11.93","volume":"8","author":"BP Imbimbo","year":"2012","unstructured":"Imbimbo BP, Ottonello S, Frisardi V, Solfrizzi V, Greco A, Seripa D, Pilotto A, Panza F (2012) Solanezumab for the treatment of mild-to-moderate Alzheimer\u2019s disease. Expert Rev Clin Immunol 8(2):135\u2013149. \n                    https:\/\/doi.org\/10.1586\/eci.11.93","journal-title":"Expert Rev Clin Immunol"},{"issue":"4","key":"1680_CR10","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3233\/jad-150136","volume":"47","author":"A Banik","year":"2015","unstructured":"Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y et al (2015) Translation of pre-clinical studies into successful clinical trials for Alzheimer\u2019s disease: what are the roadblocks and how can they be overcome? J Alzheimers Dis 47(4):815\u2013843. \n                    https:\/\/doi.org\/10.3233\/jad-150136","journal-title":"J Alzheimers Dis"},{"issue":"85","key":"1680_CR11","doi-asserted-by":"publisher","first-page":"35581","DOI":"10.18632\/oncotarget.26272","volume":"9","author":"GS Chiu","year":"2018","unstructured":"Chiu GS, Boukelmoune N, Chiang ACA, Peng B, Rao V, Kingsley C, Liu HL, Kavelaars A et al (2018) Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice. Oncotarget 9(85):35581\u201335597. \n                    https:\/\/doi.org\/10.18632\/oncotarget.26272","journal-title":"Oncotarget"},{"key":"1680_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13024-015-0035-6","volume":"10","author":"IS Lee","year":"2015","unstructured":"Lee IS, Jung K, Kim IS, Lee H, Kim M, Yun S, Hwang K, Shin JE et al (2015) Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener 10:38. \n                    https:\/\/doi.org\/10.1186\/s13024-015-0035-6","journal-title":"Mol Neurodegener"},{"key":"1680_CR13","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3389\/fnbeh.2018.00222","volume":"12","author":"P Bali","year":"2018","unstructured":"Bali P, Bammidi S, Banik A, Nehru B, Anand A (2018) CD34 and CD117 stemness of lineage-negative cells reverses memory loss induced by amyloid beta in mouse model. Front Behav Neurosci 12:222. \n                    https:\/\/doi.org\/10.3389\/fnbeh.2018.00222","journal-title":"Front Behav Neurosci"},{"issue":"2","key":"1680_CR14","doi-asserted-by":"publisher","first-page":"208","DOI":"10.2174\/1567205013666160314145347","volume":"14","author":"P Bali","year":"2017","unstructured":"Bali P, Lahiri DK, Banik A, Nehru B, Anand A (2017) Potential for stem cells therapy in Alzheimer\u2019s disease: do neurotrophic factors play critical role? Curr Alzheimer Res 14(2):208\u2013220","journal-title":"Curr Alzheimer Res"},{"key":"1680_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bbr.2015.05.014","volume":"291","author":"A Banik","year":"2015","unstructured":"Banik A, Prabhakar S, Kalra J, Anand A (2015) Effect of human umbilical cord blood derived lineage negative stem cells transplanted in amyloid-beta induced cognitive impaired mice. Behavioral brain research 291:46\u201359. \n                    https:\/\/doi.org\/10.1016\/j.bbr.2015.05.014","journal-title":"Behavioral brain research"},{"issue":"1","key":"1680_CR16","doi-asserted-by":"publisher","first-page":"14289","DOI":"10.1038\/s41598-018-32715-5","volume":"8","author":"MS Aydin","year":"2018","unstructured":"Aydin MS, Yigit EN, Vatandaslar E, Erdogan E, Ozturk G (2018) Transfer and integration of breast milk stem cells to the brain of suckling pups. Sci Rep 8(1):14289. \n                    https:\/\/doi.org\/10.1038\/s41598-018-32715-5","journal-title":"Sci Rep"},{"issue":"3","key":"1680_CR17","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/ajmg.b.30607","volume":"147","author":"Z Chen","year":"2008","unstructured":"Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC (2008) Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer\u2019s disease. Am J Med Genet B Neuropsychiatr Genet 147(3):363\u2013369. \n                    https:\/\/doi.org\/10.1002\/ajmg.b.30607","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"3","key":"1680_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s12031-018-1100-8","volume":"65","author":"Y Du","year":"2018","unstructured":"Du Y, Wu HT, Qin XY, Cao C, Liu Y, Cao ZZ, Cheng Y (2018) Postmortem brain, cerebrospinal fluid, and blood neurotrophic factor levels in. Alzheimers Dis 65(3):289\u2013300. \n                    https:\/\/doi.org\/10.1007\/s12031-018-1100-8","journal-title":"Alzheimers Dis"},{"issue":"2","key":"1680_CR19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3233\/jad-150172","volume":"46","author":"OV Forlenza","year":"2015","unstructured":"Forlenza OV, Miranda AS, Guimar I, Talib LL, Diniz BS, Gattaz WF, Teixeira AL (2015) Decreased neurotrophic support is associated with cognitive decline in non-demented subjects. J Alzheimers Dis 46(2):423\u2013429. \n                    https:\/\/doi.org\/10.3233\/jad-150172","journal-title":"J Alzheimers Dis"},{"issue":"32","key":"1680_CR20","doi-asserted-by":"publisher","first-page":"13594","DOI":"10.1073\/pnas.0901402106","volume":"106","author":"M Blurton-Jones","year":"2009","unstructured":"Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Muller FJ, Loring JF, Yamasaki TR, Poon WW et al (2009) Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A 106(32):13594\u201313599. \n                    https:\/\/doi.org\/10.1073\/pnas.0901402106","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1680_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.pharmthera.2013.01.004","volume":"138","author":"SJ Allen","year":"2013","unstructured":"Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 138(2):155\u2013175. \n                    https:\/\/doi.org\/10.1016\/j.pharmthera.2013.01.004","journal-title":"Pharmacol Ther"},{"issue":"2","key":"1680_CR22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3233\/jad-2009-1146","volume":"18","author":"G Straten","year":"2009","unstructured":"Straten G, Eschweiler GW, Maetzler W, Laske C, Leyhe T (2009) Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer\u2019s disease and normal controls. J Alzheimers Dis 18(2):331\u2013337. \n                    https:\/\/doi.org\/10.3233\/jad-2009-1146","journal-title":"J Alzheimers Dis"},{"issue":"52","key":"1680_CR23","doi-asserted-by":"publisher","first-page":"45093","DOI":"10.1074\/jbc.M111.310250","volume":"286","author":"M Airavaara","year":"2011","unstructured":"Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR (2011) Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem 286(52):45093\u201345102. \n                    https:\/\/doi.org\/10.1074\/jbc.M111.310250","journal-title":"J Biol Chem"},{"key":"1680_CR24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuropharm.2014.01.037","volume":"81","author":"S Revilla","year":"2014","unstructured":"Revilla S, Sunol C, Garcia-Mesa Y, Gimenez-Llort L, Sanfeliu C, Cristofol R (2014) Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain. Neuropharmacology 81:55\u201363. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2014.01.037","journal-title":"Neuropharmacology"},{"issue":"11","key":"1680_CR25","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/cns.12312","volume":"20","author":"S Revilla","year":"2014","unstructured":"Revilla S, Ursulet S, Alvarez-Lopez MJ, Castro-Freire M, Perpina U, Garcia-Mesa Y, Bortolozzi A, Gimenez-Llort L et al (2014) Lenti-GDNF gene therapy protects against Alzheimer\u2019s disease-like neuropathology in 3xTg-AD mice and MC65 cells. CNS Neurosci Ther 20(11):961\u2013972. \n                    https:\/\/doi.org\/10.1111\/cns.12312","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"1680_CR26","doi-asserted-by":"publisher","first-page":"e1643","DOI":"10.1371\/journal.pone.0001643","volume":"3","author":"CL Esposito","year":"2008","unstructured":"Esposito CL, D\u2019Alessio A, de Franciscis V, Cerchia L (2008) A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation. PLoS One 3(2):e1643. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0001643","journal-title":"PLoS One"},{"issue":"5","key":"1680_CR27","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.cytogfr.2015.07.007","volume":"26","author":"S Pasquin","year":"2015","unstructured":"Pasquin S, Sharma M, Gauchat JF (2015) Ciliary neurotrophic factor (CNTF): new facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. Cytokine Growth Factor Rev 26(5):507\u2013515. \n                    https:\/\/doi.org\/10.1016\/j.cytogfr.2015.07.007","journal-title":"Cytokine Growth Factor Rev"},{"issue":"11","key":"1680_CR28","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1002\/neu.480251110","volume":"25","author":"M Sendtner","year":"1994","unstructured":"Sendtner M, Carroll P, Holtmann B, Hughes RA, Thoenen H (1994) Ciliary neurotrophic factor. J Neurobiol 25(11):1436\u20131453. \n                    https:\/\/doi.org\/10.1002\/neu.480251110","journal-title":"J Neurobiol"},{"issue":"9","key":"1680_CR29","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1523\/jneurosci.3574-07.2008","volume":"28","author":"P Yang","year":"2008","unstructured":"Yang P, Arnold SA, Habas A, Hetman M, Hagg T (2008) Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice. J Neurosci 28(9):2231\u20132241. \n                    https:\/\/doi.org\/10.1523\/jneurosci.3574-07.2008","journal-title":"J Neurosci"},{"issue":"4","key":"1680_CR30","doi-asserted-by":"publisher","first-page":"S227","DOI":"10.1016\/j.jalz.2010.05.736","volume":"6","author":"J Blanchard","year":"2010","unstructured":"Blanchard J, Iqbal K, Grundke-Iqbal I (2010) Chronic treatment with a CNTF peptide enhances neuronal plasticity and alleviates cognitive impairment in 3xTgAD mice. Alzheimers Dement 6(4):S227\u2013S228","journal-title":"Alzheimers Dement"},{"issue":"22","key":"1680_CR31","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.1523\/jneurosci.4182-09.2010","volume":"30","author":"P Garcia","year":"2010","unstructured":"Garcia P, Youssef I, Utvik JK, Florent-Bechard S, Barthelemy V, Malaplate-Armand C, Kriem B, Stenger C et al (2010) Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer\u2019s disease. J Neurosci 30(22):7516\u20137527. \n                    https:\/\/doi.org\/10.1523\/jneurosci.4182-09.2010","journal-title":"J Neurosci"},{"issue":"27","key":"1680_CR32","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.1523\/jneurosci.0174-07.2007","volume":"27","author":"C Escartin","year":"2007","unstructured":"Escartin C, Pierre K, Colin A, Brouillet E, Delzescaux T, Guillermier M, Dhenain M, Deglon N et al (2007) Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. J Neurosci 27(27):7094\u20137104. \n                    https:\/\/doi.org\/10.1523\/jneurosci.0174-07.2007","journal-title":"J Neurosci"},{"issue":"1","key":"1680_CR33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/glia.22735","volume":"63","author":"JL Seidel","year":"2015","unstructured":"Seidel JL, Faideau M, Aiba I, Pannasch U, Escartin C, Rouach N, Bonvento G, Shuttleworth CW (2015) Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance. Glia 63(1):91\u2013103. \n                    https:\/\/doi.org\/10.1002\/glia.22735","journal-title":"Glia"},{"issue":"6185","key":"1680_CR34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/335070a0","volume":"335","author":"SM Hughes","year":"1988","unstructured":"Hughes SM, Lillien LE, Raff MC, Rohrer H, Sendtner M (1988) Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Nature 335(6185):70\u201373. \n                    https:\/\/doi.org\/10.1038\/335070a0","journal-title":"Nature"},{"issue":"2","key":"1680_CR35","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0165-3806(96)00180-0","volume":"98","author":"MA Kahn","year":"1997","unstructured":"Kahn MA, Ellison JA, Chang RP, Speight GJ, de Vellis J (1997) CNTF induces GFAP in a S-100 alpha brain cell population: the pattern of CNTF-alpha R suggests an indirect mode of action. Brain Res Dev Brain Res 98(2):221\u2013233","journal-title":"Brain Res Dev Brain Res"},{"issue":"2","key":"1680_CR36","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/exnr.1997.6735","volume":"150","author":"SN Hudgins","year":"1998","unstructured":"Hudgins SN, Levison SW (1998) Ciliary neurotrophic factor stimulates astroglial hypertrophy in vivo and in vitro. Exp Neurol 150(2):171\u2013182. \n                    https:\/\/doi.org\/10.1006\/exnr.1997.6735","journal-title":"Exp Neurol"},{"issue":"1","key":"1680_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2012.04.021","volume":"236","author":"DR Thal","year":"2012","unstructured":"Thal DR (2012) The role of astrocytes in amyloid beta-protein toxicity and clearance. Exp Neurol 236(1):1\u20135. \n                    https:\/\/doi.org\/10.1016\/j.expneurol.2012.04.021","journal-title":"Exp Neurol"},{"issue":"2","key":"1680_CR38","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0896-6273(00)80853-3","volume":"24","author":"L Minichiello","year":"1999","unstructured":"Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp HP et al (1999) Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24(2):401\u2013414","journal-title":"Neuron"},{"issue":"1","key":"1680_CR39","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/1098-2396(200010)38:1<102::Aid-syn11>3.0.Co;2-k","volume":"38","author":"T Saarelainen","year":"2000","unstructured":"Saarelainen T, Pussinen R, Koponen E, Alhonen L, Wong G, Sirvio J, Castren E (2000) Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP. Synapse (N Y) 38(1):102\u2013104. \n                    https:\/\/doi.org\/10.1002\/1098-2396(200010)38:1<102::Aid-syn11>3.0.Co;2-k","journal-title":"Synapse (N Y)"},{"issue":"6","key":"1680_CR40","doi-asserted-by":"publisher","first-page":"e0131525","DOI":"10.1371\/journal.pone.0131525","volume":"10","author":"L Zhang","year":"2015","unstructured":"Zhang L, Fang Y, Xu Y, Lian Y, Xie N, Wu T, Zhang H, Sun L et al (2015) Curcumin Improves Amyloid beta-Peptide (1\u201342) Induced spatial memory deficits through BDNF-ERK signaling pathway. PLoS One 10(6):e0131525. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0131525","journal-title":"PLoS One"},{"key":"1680_CR41","doi-asserted-by":"publisher","unstructured":"Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182(3):311\u2013322. \n                    https:\/\/doi.org\/10.1002\/(sici)1097-4652(200003)182:3<311::aid-jcp1>3.0.co;2-9","DOI":"10.1002\/(sici)1097-4652(200003)182:3<311::aid-jcp1>3.0.co;2-9"},{"issue":"1","key":"1680_CR42","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1365-2184.1992.tb01435.x","volume":"25","author":"S Bruno","year":"1992","unstructured":"Bruno S, Darzynkiewicz Z (1992) Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif 25(1):31\u201340","journal-title":"Cell Prolif"},{"key":"1680_CR43","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev.neuro.26.041002.131421","volume":"26","author":"RA Segal","year":"2003","unstructured":"Segal RA (2003) Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci 26:299\u2013330. \n                    https:\/\/doi.org\/10.1146\/annurev.neuro.26.041002.131421","journal-title":"Annu Rev Neurosci"},{"issue":"5","key":"1680_CR44","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1172\/jci43992","volume":"121","author":"M Cazorla","year":"2011","unstructured":"Cazorla M, Premont J, Mann A, Girard N, Kellendonk C, Rognan D (2011) Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest 121(5):1846\u20131857. \n                    https:\/\/doi.org\/10.1172\/jci43992","journal-title":"J Clin Invest"},{"key":"1680_CR45","doi-asserted-by":"publisher","unstructured":"Oberheim NA, Goldman SA, Nedergaard M (2012) Heterogeneity of astrocytic form and function. Methods in molecular biology (Clifton, NJ) 814:23\u201345. \n                    https:\/\/doi.org\/10.1007\/978-1-61779-452-0_3","DOI":"10.1007\/978-1-61779-452-0_3"},{"issue":"2","key":"1680_CR46","doi-asserted-by":"publisher","first-page":"139","DOI":"10.2174\/157015906776359577","volume":"4","author":"T Niikura","year":"2006","unstructured":"Niikura T, Tajima H, Kita Y (2006) Neuronal cell death in Alzheimer\u2019s disease and a neuroprotective factor, humanin. Curr Neuropharmacol 4(2):139\u2013147","journal-title":"Curr Neuropharmacol"},{"key":"1680_CR47","doi-asserted-by":"publisher","unstructured":"Nishizaki T (2018) Fe(3+) Facilitates Endocytic Internalization of Extracellular Abeta1\u201342 and Enhances Abeta1\u201342-Induced Caspase-3\/Caspase-4 Activation and Neuronal Cell Death. Mol Neurobiol. \n                    https:\/\/doi.org\/10.1007\/s12035-018-1408-y","DOI":"10.1007\/s12035-018-1408-y"},{"issue":"2\u20133","key":"1680_CR48","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1006\/jsbi.2000.4274","volume":"130","author":"S Varadarajan","year":"2000","unstructured":"Varadarajan S, Yatin S, Aksenova M, Butterfield DA (2000) Review: Alzheimer\u2019s amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130(2\u20133):184\u2013208. \n                    https:\/\/doi.org\/10.1006\/jsbi.2000.4274","journal-title":"J Struct Biol"},{"key":"1680_CR49","unstructured":"Parker Jr WD, Davis RE (1997) Primary mitochondrial DNA defects as a causative event in Alzheimer\u2019s disease. Mitochondria and free radicals in neurodegenerative diseases. Wiley-Liss, New York, pp 319\u2013333"},{"issue":"11","key":"1680_CR50","first-page":"2070","volume":"19","author":"DW Qu","year":"2015","unstructured":"Qu DW, Liu Y, Wang L, Xiong Y, Zhang CL, Gao DS (2015) Glial cell line-derived neurotrophic factor promotes proliferation of neuroglioma cells by up-regulation of cyclins PCNA and Ki-67. Eur Rev Med Pharmacol Sci 19(11):2070\u20132075","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1\u20132","key":"1680_CR51","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0169-328X(03)00286-9","volume":"116","author":"J Jiao","year":"2003","unstructured":"Jiao J, Kaur N, Lu B, Reeves SA, Halvorsen SW (2003) Initiation and maintenance of CNTF-Jak\/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors. Brain Res Mol Brain Res 116(1\u20132):135\u2013146","journal-title":"Brain Res Mol Brain Res"},{"issue":"12","key":"1680_CR52","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1111\/j.1460-9568.2006.05230.x","volume":"24","author":"SG Leaver","year":"2006","unstructured":"Leaver SG, Cui Q, Bernard O, Harvey AR (2006) Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice. Eur J Neurosci 24(12):3323\u20133332. \n                    https:\/\/doi.org\/10.1111\/j.1460-9568.2006.05230.x","journal-title":"Eur J Neurosci"},{"issue":"4","key":"1680_CR53","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/glia.10048","volume":"37","author":"C Dallner","year":"2002","unstructured":"Dallner C, Woods AG, Deller T, Kirsch M, Hofmann HD (2002) CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain. Glia 37(4):374\u2013378","journal-title":"Glia"},{"issue":"7","key":"1680_CR54","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41593-018-0175-4","volume":"21","author":"J Park","year":"2018","unstructured":"Park J, Wetzel I, Marriott I, Dreau D, D\u2019Avanzo C, Kim DY, Tanzi RE, Cho H (2018) A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer\u2019s disease. Nat Neurosci 21(7):941\u2013951. \n                    https:\/\/doi.org\/10.1038\/s41593-018-0175-4","journal-title":"Nat Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01680-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-01680-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01680-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T19:32:54Z","timestamp":1593113574000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-01680-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1680"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-01680-z","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,27]]},"assertion":[{"value":"2 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}