{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:33:31Z","timestamp":1772120011577,"version":"3.50.1"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31-DA03689"],"award-info":[{"award-number":["F31-DA03689"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32-DA007288"],"award-info":[{"award-number":["T32-DA007288"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01-DA033342A"],"award-info":[{"award-number":["R01-DA033342A"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50-DA015369"],"award-info":[{"award-number":["P50-DA015369"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01-DA046476"],"award-info":[{"award-number":["R01-DA046476"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01-DA042852"],"award-info":[{"award-number":["R01-DA042852"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS098772"],"award-info":[{"award-number":["R01-NS098772"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12035-019-01711-9","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T03:03:36Z","timestamp":1564369416000},"page":"346-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking"],"prefix":"10.1007","volume":"57","author":[{"given":"William C.","family":"Buchta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubin","family":"Moutal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Hines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Garcia-Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander C. W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kalivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-4436","authenticated-orcid":false,"given":"Arthur C.","family":"Riegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"issue":"45","key":"1711_CR1","doi-asserted-by":"publisher","first-page":"10867","DOI":"10.1523\/JNEUROSCI.1821-17.2017","volume":"37","author":"Y Dong","year":"2017","unstructured":"Dong Y, Taylor JR, Wolf ME, Shaham Y (2017) Circuit and synaptic plasticity mechanisms of drug relapse. J Neurosci 37(45):10867\u201310876. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.1821-17.2017","journal-title":"J Neurosci"},{"issue":"11","key":"1711_CR2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nrn3119","volume":"12","author":"RZ Goldstein","year":"2011","unstructured":"Goldstein RZ, Volkow ND (2011) Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12(11):652\u2013669. \nhttps:\/\/doi.org\/10.1038\/nrn3119","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"1711_CR3","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1176\/appi.ajp.159.10.1642","volume":"159","author":"RZ Goldstein","year":"2002","unstructured":"Goldstein RZ, Volkow ND (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159(10):1642\u20131652. \nhttps:\/\/doi.org\/10.1176\/appi.ajp.159.10.1642","journal-title":"Am J Psychiatry"},{"issue":"Pt a","key":"1711_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.brainres.2015.02.003","volume":"1628","author":"WC Buchta","year":"2015","unstructured":"Buchta WC, Riegel AC (2015) Chronic cocaine disrupts mesocortical learning mechanisms. Brain Res 1628(Pt a):88\u2013103. \nhttps:\/\/doi.org\/10.1016\/j.brainres.2015.02.003","journal-title":"Brain Res"},{"issue":"4","key":"1711_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.neuron.2008.06.020","volume":"59","author":"S Pulipparacharuvil","year":"2008","unstructured":"Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D et al (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59(4):621\u2013633. \nhttps:\/\/doi.org\/10.1016\/j.neuron.2008.06.020","journal-title":"Neuron"},{"issue":"6","key":"1711_CR6","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nn.3094","volume":"15","author":"DM Dietz","year":"2012","unstructured":"Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS et al (2012) Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci 15(6):891\u2013896. \nhttps:\/\/doi.org\/10.1038\/nn.3094","journal-title":"Nat Neurosci"},{"issue":"9","key":"1711_CR7","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/tra.12295","volume":"16","author":"LM DePoy","year":"2015","unstructured":"DePoy LM, Gourley SL (2015) Synaptic cytoskeletal plasticity in the prefrontal cortex following psychostimulant exposure. Traffic 16(9):919\u2013940. \nhttps:\/\/doi.org\/10.1111\/tra.12295","journal-title":"Traffic"},{"issue":"17","key":"1711_CR8","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.1523\/JNEUROSCI.2767-17.2018","volume":"38","author":"J Parrilla-Carrero","year":"2018","unstructured":"Parrilla-Carrero J, Buchta WC, Goswamee P, Culver O, McKendrick G, Harlan B, Moutal A, Penrod R et al (2018) Restoration of Kv7 channel-mediated inhibition reduces cued-reinstatement of cocaine seeking. J Neurosci 38(17):4212\u20134229. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.2767-17.2018","journal-title":"J Neurosci"},{"issue":"5","key":"1711_CR9","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/ejn.13159","volume":"43","author":"KD Lominac","year":"2016","unstructured":"Lominac KD, Quadir SG, Barrett HM, McKenna CL, Schwartz LM, Ruiz PN, Wroten MG, Campbell RR et al (2016) Prefrontal glutamate correlates of methamphetamine sensitization and preference. Eur J Neurosci 43(5):689\u2013702. \nhttps:\/\/doi.org\/10.1111\/ejn.13159","journal-title":"Eur J Neurosci"},{"key":"1711_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neuropharm.2015.10.038","volume":"102","author":"CB Shin","year":"2016","unstructured":"Shin CB, Serchia MM, Shahin JR, Ruppert-Majer MA, Kippin TE, Szumlinski KK (2016) Incubation of cocaine-craving relates to glutamate over-flow within ventromedial prefrontal cortex. Neuropharmacology 102:103\u2013110. \nhttps:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.038","journal-title":"Neuropharmacology"},{"key":"1711_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.neuropharm.2017.10.024","volume":"128","author":"CB Shin","year":"2018","unstructured":"Shin CB, Templeton TJ, Chiu AS, Kim J, Gable ES, Vieira PA, Kippin TE, Szumlinski KK (2018) Endogenous glutamate within the prelimbic and infralimbic cortices regulates the incubation of cocaine-seeking in rats. Neuropharmacology 128:293\u2013300. \nhttps:\/\/doi.org\/10.1016\/j.neuropharm.2017.10.024","journal-title":"Neuropharmacology"},{"issue":"3","key":"1711_CR12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/adb.12249","volume":"21","author":"B Gonzalez","year":"2016","unstructured":"Gonzalez B, Rivero-Echeto C, Muniz JA, Cadet JL, Garcia-Rill E, Urbano FJ, Bisagno V (2016) Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1\/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex. Addict Biol 21(3):589\u2013602. \nhttps:\/\/doi.org\/10.1111\/adb.12249","journal-title":"Addict Biol"},{"issue":"11","key":"1711_CR13","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/syn.20797","volume":"64","author":"K Kurokawa","year":"2010","unstructured":"Kurokawa K, Shibasaki M, Ohkuma S (2010) Methamphetamine-induced up-regulation of alpha2\/delta subunit of voltage-gated calcium channels is regulated by DA receptors. Synapse 64(11):822\u2013828. \nhttps:\/\/doi.org\/10.1002\/syn.20797","journal-title":"Synapse"},{"issue":"3","key":"1711_CR14","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.neuroscience.2009.07.017","volume":"163","author":"M Shibasaki","year":"2009","unstructured":"Shibasaki M, Kurokawa K, Ohkuma S (2009) Role of alpha2\/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization. Neuroscience 163(3):731\u2013734. \nhttps:\/\/doi.org\/10.1016\/j.neuroscience.2009.07.017","journal-title":"Neuroscience"},{"issue":"6540","key":"1711_CR15","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/376509a0","volume":"376","author":"Y Goshima","year":"1995","unstructured":"Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM (1995) Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature 376(6540):509\u2013514. \nhttps:\/\/doi.org\/10.1038\/376509a0","journal-title":"Nature"},{"issue":"45","key":"1711_CR16","doi-asserted-by":"publisher","first-page":"31375","DOI":"10.1074\/jbc.M109.009951","volume":"284","author":"JM Brittain","year":"2009","unstructured":"Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R (2009) An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. J Biol Chem 284(45):31375\u201331390. \nhttps:\/\/doi.org\/10.1074\/jbc.M109.009951","journal-title":"J Biol Chem"},{"issue":"1","key":"1711_CR17","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.1471-4159.2009.06140.x","volume":"110","author":"AC Boudreau","year":"2009","unstructured":"Boudreau AC, Ferrario CR, Glucksman MJ, Wolf ME (2009) Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. J Neurochem 110(1):363\u2013377. \nhttps:\/\/doi.org\/10.1111\/j.1471-4159.2009.06140.x","journal-title":"J Neurochem"},{"issue":"1","key":"1711_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/mp.2016.12","volume":"22","author":"F Liu","year":"2017","unstructured":"Liu F, Laguesse S, Legastelois R, Morisot N, Ben Hamida S, Ron D (2017) mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. Mol Psychiatry 22(1):89\u2013101. \nhttps:\/\/doi.org\/10.1038\/mp.2016.12","journal-title":"Mol Psychiatry"},{"issue":"1","key":"1711_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cell.2004.11.012","volume":"120","author":"T Yoshimura","year":"2005","unstructured":"Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K (2005) GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120(1):137\u2013149. \nhttps:\/\/doi.org\/10.1016\/j.cell.2004.11.012","journal-title":"Cell"},{"key":"1711_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuroscience.2018.04.002","volume":"381","author":"A Moutal","year":"2018","unstructured":"Moutal A, Sun L, Yang X, Li W, Cai S, Luo S, Khanna R (2018) CRMP2-neurofibromin interface drives NF1-related pain. Neuroscience 381:79\u201390. \nhttps:\/\/doi.org\/10.1016\/j.neuroscience.2018.04.002","journal-title":"Neuroscience"},{"issue":"1","key":"1711_CR21","doi-asserted-by":"publisher","first-page":"e565","DOI":"10.1097\/PR9.0000000000000565","volume":"1","author":"A Moutal","year":"2016","unstructured":"Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R (2016) Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Rep 1(1):e565. \nhttps:\/\/doi.org\/10.1097\/PR9.0000000000000565","journal-title":"Pain Rep"},{"issue":"11","key":"1711_CR22","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1097\/j.pain.0000000000001026","volume":"158","author":"A Moutal","year":"2017","unstructured":"Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, Bellampalli SS, Chew LA et al (2017) Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors. Pain 158(11):2203\u20132221. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000001026","journal-title":"Pain"},{"key":"1711_CR23","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1242\/jcs.053280","volume":"23","author":"XX Chi","year":"2009","unstructured":"Chi XX, Schmutzler BS, Brittain JM, Hingtgen CM, Nicol GD, Khanna R (2009) Regulation of N-type voltage-gated calcium (CaV2.2) channels and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. J Cell Sci 23:4351\u20134362","journal-title":"J Cell Sci"},{"issue":"5","key":"1711_CR24","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/adb.12653","volume":"24","author":"Sami Ben Hamida","year":"2018","unstructured":"Ben Hamida S, Laguesse S, Morisot N, Park JH, Phuamluong K, Berger AL, Park KD, Ron D (2018) Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking. Addict Biol. \nhttps:\/\/doi.org\/10.1111\/adb.12653","journal-title":"Addiction Biology"},{"issue":"1","key":"1711_CR25","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/mp.2017.252","volume":"23","author":"F Liu","year":"2018","unstructured":"Liu F, Laguesse S, Legastelois R, Morisot N, Ben Hamida S, Ron D (2018) mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. Mol Psychiatry 23(1):164. \nhttps:\/\/doi.org\/10.1038\/mp.2017.252","journal-title":"Mol Psychiatry"},{"issue":"2","key":"1711_CR26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/mp.2008.53","volume":"15","author":"NS Tannu","year":"2010","unstructured":"Tannu NS, Howell LL, Hemby SE (2010) Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration. Mol Psychiatry 15(2):185\u2013203. \nhttps:\/\/doi.org\/10.1038\/mp.2008.53","journal-title":"Mol Psychiatry"},{"issue":"7","key":"1711_CR27","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/pmic.200600595","volume":"7","author":"T Iwazaki","year":"2007","unstructured":"Iwazaki T, McGregor IS, Matsumoto I (2007) Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitization. Proteomics 7(7):1131\u20131139. \nhttps:\/\/doi.org\/10.1002\/pmic.200600595","journal-title":"Proteomics"},{"issue":"5","key":"1711_CR28","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1021\/pr800029h","volume":"7","author":"FH Kobeissy","year":"2008","unstructured":"Kobeissy FH, Warren MW, Ottens AK, Sadasivan S, Zhang Z, Gold MS, Wang KK (2008) Psychoproteomic analysis of rat cortex following acute methamphetamine exposure. J Proteome Res 7(5):1971\u20131983. \nhttps:\/\/doi.org\/10.1021\/pr800029h","journal-title":"J Proteome Res"},{"issue":"7","key":"1711_CR29","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1097\/j.pain.0000000000000147","volume":"156","author":"L Francois-Moutal","year":"2015","unstructured":"Francois-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W et al (2015) A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain 156(7):1247\u20131264. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000000147","journal-title":"Pain"},{"issue":"7","key":"1711_CR30","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.biopsych.2016.08.033","volume":"81","author":"S Spencer","year":"2017","unstructured":"Spencer S, Garcia-Keller C, Roberts-Wolfe D, Heinsbroek JA, Mulvaney M, Sorrell A, Kalivas PW (2017) Cocaine use reverses striatal plasticity produced during cocaine seeking. Biol Psychiatry 81(7):616\u2013624. \nhttps:\/\/doi.org\/10.1016\/j.biopsych.2016.08.033","journal-title":"Biol Psychiatry"},{"key":"1711_CR31","doi-asserted-by":"publisher","first-page":"100022","DOI":"10.1016\/j.ynpai.2018.07.003","volume":"5","author":"Aubin Moutal","year":"2019","unstructured":"Moutal A, Luo S, Largent-Milnes TM, Vanderah TW, Khanna R (2019) Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiol Pain 5. doi:\nhttps:\/\/doi.org\/10.1016\/j.ynpai.2018.07.003","journal-title":"Neurobiology of Pain"},{"issue":"7","key":"1711_CR32","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1097\/j.pain.0000000000001524","volume":"160","author":"Rajesh Khanna","year":"2019","unstructured":"Khanna R, Yu J, Yang X, Moutal A, Chefdeville A, Gokhale V, Shuja Z, Chew LA et al (2019) Targeting the CaValpha-CaVbeta interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy. Pain. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000001524","journal-title":"PAIN"},{"issue":"7","key":"1711_CR33","doi-asserted-by":"publisher","first-page":"5241","DOI":"10.1007\/s12035-018-1445-6","volume":"56","author":"Jie Yu","year":"2018","unstructured":"Yu J, Moutal A, Dorame A, Bellampalli SS, Chefdeville A, Kanazawa I, Pham NYN, Park KD et al (2018) Phosphorylated CRMP2 regulates spinal nociceptive neurotransmission. Mol Neurobiol. \nhttps:\/\/doi.org\/10.1007\/s12035-018-1445-6","journal-title":"Molecular Neurobiology"},{"issue":"12","key":"1711_CR34","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1097\/j.pain.0000000000001002","volume":"158","author":"A Moutal","year":"2017","unstructured":"Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, Francois-Moutal L, Chew LA et al (2017) CRISPR\/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain 158(12):2301\u20132319. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000001002","journal-title":"Pain"},{"issue":"5","key":"1711_CR35","doi-asserted-by":"publisher","first-page":"4403","DOI":"10.1007\/s12035-017-0653-9","volume":"55","author":"A Moutal","year":"2018","unstructured":"Moutal A, Villa LS, Yeon SK, Householder KT, Park KD, Sirianni RW, Khanna R (2018) CRMP2 phosphorylation drives glioblastoma cell proliferation. Mol Neurobiol 55(5):4403\u20134416. \nhttps:\/\/doi.org\/10.1007\/s12035-017-0653-9","journal-title":"Mol Neurobiol"},{"issue":"11","key":"1711_CR36","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1038\/mp.2017.117","volume":"23","author":"A Moutal","year":"2018","unstructured":"Moutal A, Dustrude ET, Largent-Milnes TM, Vanderah TW, Khanna M, Khanna R (2018) Blocking CRMP2 SUMOylation reverses neuropathic pain. Mol Psychiatry 23(11):2119\u20132121. \nhttps:\/\/doi.org\/10.1038\/mp.2017.117","journal-title":"Mol Psychiatry"},{"issue":"12","key":"1711_CR37","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1111\/bph.13737","volume":"175","author":"A Moutal","year":"2018","unstructured":"Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, Francois-Moutal L, Perez-Miller S et al (2018) Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides. Br J Pharmacol 175(12):2244\u20132260. \nhttps:\/\/doi.org\/10.1111\/bph.13737","journal-title":"Br J Pharmacol"},{"issue":"2","key":"1711_CR38","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/j.pain.0000000000000767","volume":"158","author":"MM Ibrahim","year":"2017","unstructured":"Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP et al (2017) Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain 158(2):347\u2013360. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000000767","journal-title":"Pain"},{"issue":"52","key":"1711_CR39","doi-asserted-by":"publisher","first-page":"E8443","DOI":"10.1073\/pnas.1610531113","volume":"113","author":"ET Dustrude","year":"2016","unstructured":"Dustrude ET, Moutal A, Yang X, Wang Y, Khanna M, Khanna R (2016) Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. Proc Natl Acad Sci U S A 113(52):E8443\u2013E8452. \nhttps:\/\/doi.org\/10.1073\/pnas.1610531113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"1711_CR40","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1097\/j.pain.0000000000000555","volume":"157","author":"A Moutal","year":"2016","unstructured":"Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD et al (2016) (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain 157(7):1448\u20131463. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000000555","journal-title":"Pain"},{"issue":"17","key":"1711_CR41","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1158\/0008-5472.CAN-14-0631","volume":"75","author":"A Moutal","year":"2015","unstructured":"Moutal A, Honnorat J, Massoma P, Desormeaux P, Bertrand C, Malleval C, Watrin C, Chounlamountri N et al (2015) CRMP5 controls glioblastoma cell proliferation and survival through notch-dependent signaling. Cancer Res 75(17):3519\u20133528. \nhttps:\/\/doi.org\/10.1158\/0008-5472.CAN-14-0631","journal-title":"Cancer Res"},{"issue":"3","key":"1711_CR42","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s12035-015-9141-2","volume":"53","author":"A Moutal","year":"2016","unstructured":"Moutal A, Francois-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD et al (2016) (S)-Lacosamide binding to collapsin response mediator protein 2 (CRMP2) regulates CaV2.2 activity by subverting its phosphorylation by Cdk5. Mol Neurobiol 53(3):1959\u20131976. \nhttps:\/\/doi.org\/10.1007\/s12035-015-9141-2","journal-title":"Mol Neurobiol"},{"key":"1711_CR43","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3389\/fncel.2014.00471","volume":"8","author":"A Moutal","year":"2014","unstructured":"Moutal A, Francois-Moutal L, Brittain JM, Khanna M, Khanna R (2014) Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides. Front Cell Neurosci 8:471. \nhttps:\/\/doi.org\/10.3389\/fncel.2014.00471","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"1711_CR44","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/19336950.2017.1299838","volume":"11","author":"ET Dustrude","year":"2017","unstructured":"Dustrude ET, Perez-Miller S, Francois-Moutal L, Moutal A, Khanna M, Khanna R (2017) A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function. Channels 11(4):316\u2013328. \nhttps:\/\/doi.org\/10.1080\/19336950.2017.1299838","journal-title":"Channels"},{"issue":"10","key":"1711_CR45","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1097\/j.pain.0000000000001294","volume":"159","author":"L Francois-Moutal","year":"2018","unstructured":"Francois-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S et al (2018) Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain. Pain 159(10):2115\u20132127. \nhttps:\/\/doi.org\/10.1097\/j.pain.0000000000001294","journal-title":"Pain"},{"issue":"40","key":"1711_CR46","doi-asserted-by":"publisher","first-page":"27393","DOI":"10.1074\/jbc.M109.000240","volume":"284","author":"Y Uchida","year":"2009","unstructured":"Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y (2009) Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem 284(40):27393\u201327401","journal-title":"J Biol Chem"},{"issue":"19","key":"1711_CR47","doi-asserted-by":"publisher","first-page":"13265","DOI":"10.1074\/jbc.M807664200","volume":"284","author":"M Varrin-Doyer","year":"2009","unstructured":"Varrin-Doyer M, Vincent P, Cavagna S, Auvergnon N, Noraz N, Rogemond V, Honnorat J, Moradi-Ameli M et al (2009) Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem 284(19):13265\u201313276","journal-title":"J Biol Chem"},{"issue":"3","key":"1711_CR48","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00213-013-3120-y","volume":"229","author":"JM Bossert","year":"2013","unstructured":"Bossert JM, Marchant NJ, Calu DJ, Shaham Y (2013) The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research. Psychopharmacology 229(3):453\u2013476. \nhttps:\/\/doi.org\/10.1007\/s00213-013-3120-y","journal-title":"Psychopharmacology"},{"issue":"1\u20132","key":"1711_CR49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00213-002-1224-x","volume":"168","author":"Y Shaham","year":"2003","unstructured":"Shaham Y, Shalev U, Lu L, de Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168(1\u20132):3\u201320. \nhttps:\/\/doi.org\/10.1007\/s00213-002-1224-x","journal-title":"Psychopharmacology"},{"key":"1711_CR50","doi-asserted-by":"publisher","first-page":"100022","DOI":"10.1016\/j.ynpai.2018.07.003","volume":"5","author":"A Moutal","year":"2018","unstructured":"Moutal A, Luo S, Largent-Milnes TM, Vanderah TW, Khanna R (2018) Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiol Pain 5:100022. \nhttps:\/\/doi.org\/10.1016\/j.ynpai.2018.07.003","journal-title":"Neurobiol Pain"},{"issue":"16","key":"1711_CR51","doi-asserted-by":"publisher","first-page":"5649","DOI":"10.1523\/JNEUROSCI.4564-13.2014","volume":"34","author":"HW Shen","year":"2014","unstructured":"Shen HW, Scofield MD, Boger H, Hensley M, Kalivas PW (2014) Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse. J Neurosci 34(16):5649\u20135657. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.4564-13.2014","journal-title":"J Neurosci"},{"issue":"15","key":"1711_CR52","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.1523\/JNEUROSCI.3997-14.2015","volume":"35","author":"M D\u2019Arco","year":"2015","unstructured":"D\u2019Arco M, Margas W, Cassidy JS, Dolphin AC (2015) The upregulation of alpha2delta-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons. J Neurosci 35(15):5891\u20135903. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.3997-14.2015","journal-title":"J Neurosci"},{"issue":"7401","key":"1711_CR53","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nature11033","volume":"486","author":"MB Hoppa","year":"2012","unstructured":"Hoppa MB, Lana B, Margas W, Dolphin AC, Ryan TA (2012) alpha2delta expression sets presynaptic calcium channel abundance and release probability. Nature 486(7401):122\u2013125. \nhttps:\/\/doi.org\/10.1038\/nature11033","journal-title":"Nature"},{"issue":"38","key":"1711_CR54","doi-asserted-by":"publisher","first-page":"12856","DOI":"10.1523\/JNEUROSCI.2700-10.2010","volume":"30","author":"A Tran-Van-Minh","year":"2010","unstructured":"Tran-Van-Minh A, Dolphin AC (2010) The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2. J Neurosci 30(38):12856\u201312867. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.2700-10.2010","journal-title":"J Neurosci"},{"issue":"25","key":"1711_CR55","doi-asserted-by":"publisher","first-page":"8605","DOI":"10.1523\/JNEUROSCI.1204-13.2014","volume":"34","author":"S Spencer","year":"2014","unstructured":"Spencer S, Brown RM, Quintero GC, Kupchik YM, Thomas CA, Reissner KJ, Kalivas PW (2014) alpha2delta-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse. J Neurosci 34(25):8605\u20138611. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.1204-13.2014","journal-title":"J Neurosci"},{"issue":"9","key":"1711_CR56","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1073\/pnas.0708930105","volume":"105","author":"J Hendrich","year":"2008","unstructured":"Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A et al (2008) Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A 105(9):3628\u20133633. \nhttps:\/\/doi.org\/10.1073\/pnas.0708930105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1711_CR57","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","volume":"139","author":"C Eroglu","year":"2009","unstructured":"Eroglu C, Allen NJ, Susman MW, O\u2019Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB et al (2009) Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell 139(2):380\u2013392. \nhttps:\/\/doi.org\/10.1016\/j.cell.2009.09.025","journal-title":"Cell"},{"issue":"31","key":"1711_CR58","doi-asserted-by":"publisher","first-page":"23973","DOI":"10.1074\/jbc.M001032200","volume":"275","author":"N Arimura","year":"2000","unstructured":"Arimura N, Inagaki N, Chihara K, Menager C, Nakamura N, Amano M, Iwamatsu A, Goshima Y et al (2000) Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. J Biol Chem 275(31):23973\u201323980. \nhttps:\/\/doi.org\/10.1074\/jbc.M001032200","journal-title":"J Biol Chem"},{"issue":"Pt 23","key":"1711_CR59","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1242\/jcs.053280","volume":"122","author":"XX Chi","year":"2009","unstructured":"Chi XX, Schmutzler BS, Brittain JM, Wang Y, Hingtgen CM, Nicol GD, Khanna R (2009) Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. J Cell Sci 122(Pt 23):4351\u20134362. \nhttps:\/\/doi.org\/10.1242\/jcs.053280","journal-title":"J Cell Sci"},{"issue":"3","key":"1711_CR60","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1471-4159.2008.05794.x","volume":"108","author":"J Schumann","year":"2009","unstructured":"Schumann J, Michaeli A, Yaka R (2009) Src-protein tyrosine kinases are required for cocaine-induced increase in the expression and function of the NMDA receptor in the ventral tegmental area. J Neurochem 108(3):697\u2013706. \nhttps:\/\/doi.org\/10.1111\/j.1471-4159.2008.05794.x","journal-title":"J Neurochem"},{"issue":"5","key":"1711_CR61","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s00213-018-4865-0","volume":"235","author":"A Belin-Rauscent","year":"2018","unstructured":"Belin-Rauscent A, Lacoste J, Hermine O, Moussy A, Everitt BJ, Belin D (2018) Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats. Psychopharmacology 235(5):1545\u20131556. \nhttps:\/\/doi.org\/10.1007\/s00213-018-4865-0","journal-title":"Psychopharmacology"},{"issue":"10","key":"1711_CR62","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1038\/npp.2017.90","volume":"42","author":"JM Otis","year":"2017","unstructured":"Otis JM, Mueller D (2017) Reversal of cocaine-associated synaptic plasticity in medial prefrontal cortex parallels elimination of memory retrieval. Neuropsychopharmacology 42(10):2000\u20132010. \nhttps:\/\/doi.org\/10.1038\/npp.2017.90","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"1711_CR63","doi-asserted-by":"publisher","first-page":"ENEURO.0308","DOI":"10.1523\/ENEURO.0308-17.2017","volume":"4","author":"JI Pena-Bravo","year":"2017","unstructured":"Pena-Bravo JI, Reichel CM, Lavin A (2017) Abstinence from cocaine-induced conditioned place preference produces discrete changes in glutamatergic synapses onto deep layer 5\/6 neurons from prelimbic and infralimbic cortices. eNeuro 4(6):ENEURO.0308\u2013ENEU17.2017. \nhttps:\/\/doi.org\/10.1523\/ENEURO.0308-17.2017","journal-title":"eNeuro"},{"issue":"4","key":"1711_CR64","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1523\/JNEUROSCI.2257-16.2016","volume":"37","author":"H Ruan","year":"2017","unstructured":"Ruan H, Yao WD (2017) Cocaine promotes coincidence detection and lowers induction threshold during Hebbian associative synaptic potentiation in prefrontal cortex. J Neurosci 37(4):986\u2013997. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.2257-16.2016","journal-title":"J Neurosci"},{"issue":"43","key":"1711_CR65","doi-asserted-by":"publisher","first-page":"37778","DOI":"10.1074\/jbc.M111.255455","volume":"286","author":"JM Brittain","year":"2011","unstructured":"Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H et al (2011) Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2). J Biol Chem 286(43):37778\u201337792. \nhttps:\/\/doi.org\/10.1074\/jbc.M111.255455","journal-title":"J Biol Chem"},{"issue":"6384","key":"1711_CR66","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.aao2300","volume":"360","author":"H Abe","year":"2018","unstructured":"Abe H, Jitsuki S, Nakajima W, Murata Y, Jitsuki-Takahashi A, Katsuno Y, Tada H, Sano A et al (2018) CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage. Science 360(6384):50\u201357. \nhttps:\/\/doi.org\/10.1126\/science.aao2300","journal-title":"Science"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01711-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-01711-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01711-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T19:46:37Z","timestamp":1595879197000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-01711-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,29]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["1711"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-01711-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/533083","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,29]]},"assertion":[{"value":"26 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All methods used followed National Institutes of Health guidelines for care of laboratory animals and were approved by the Medical University of South Carolina Internal Animal Care and Use Committee.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare they have no conflict of interest. W.C.B. is currently employed as a Medical Writer and Consultant at Whitsell Innovations, Inc.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}