{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:47:49Z","timestamp":1777592869887,"version":"3.51.4"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD072754"],"award-info":[{"award-number":["HD072754"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD082567"],"award-info":[{"award-number":["HD082567"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD012303"],"award-info":[{"award-number":["HD012303"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["DK063491"],"award-info":[{"award-number":["DK063491"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["CA023100"],"award-info":[{"award-number":["CA023100"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["ES010337"],"award-info":[{"award-number":["ES010337"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD084759"],"award-info":[{"award-number":["HD084759"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["GM083275"],"award-info":[{"award-number":["GM083275"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD098652"],"award-info":[{"award-number":["HD098652"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["1018024"],"award-info":[{"award-number":["1018024"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["IRP finds"],"award-info":[{"award-number":["IRP finds"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY027011"],"award-info":[{"award-number":["EY027011"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s12035-019-01781-9","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T03:02:43Z","timestamp":1573268563000},"page":"1217-1232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-5964","authenticated-orcid":false,"given":"Erica C.","family":"Pandolfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Breuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet Anh","family":"Nguyen Huu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulasi","family":"Talluri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Sora","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-4225","authenticated-orcid":false,"given":"Dorota","family":"Skowronska-Krawczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-8437","authenticated-orcid":false,"given":"Michael R.","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-0410","authenticated-orcid":false,"given":"Pamela L.","family":"Mellon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-1369","authenticated-orcid":false,"given":"Hanne M.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,9]]},"reference":[{"issue":"6","key":"1781_CR1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nn.2545","volume":"13","author":"T Shimogori","year":"2010","unstructured":"Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A et al (2010) A genomic atlas of mouse hypothalamic development. Nat Neurosci 13(6):767\u2013775. \nhttps:\/\/doi.org\/10.1038\/nn.2545","journal-title":"Nat Neurosci"},{"issue":"7124","key":"1781_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nature05453","volume":"445","author":"ES Lein","year":"2007","unstructured":"Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS et al (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445(7124):168\u2013176","journal-title":"Nature"},{"issue":"13","key":"1781_CR3","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1016\/j.celrep.2017.03.004","volume":"18","author":"R Chen","year":"2017","unstructured":"Chen R, Wu X, Jiang L, Zhang Y (2017) Single-cell RNA-Seq reveals hypothalamic cell diversity. Cell Rep 18(13):3227\u20133241. \nhttps:\/\/doi.org\/10.1016\/j.celrep.2017.03.004","journal-title":"Cell Rep"},{"issue":"5705","key":"1781_CR4","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1126\/science.1104935","volume":"306","author":"PA Gray","year":"2004","unstructured":"Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI et al (2004) Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306(5705):2255\u20132257. \nhttps:\/\/doi.org\/10.1126\/science.1104935","journal-title":"Science"},{"issue":"10","key":"1781_CR5","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/sj.ejhg.5200540","volume":"8","author":"L Pasquier","year":"2000","unstructured":"Pasquier L, Dubourg C, Blayau M, Lazaro L, Le Marec B, David V, Odent S (2000) A new mutation in the six-domain of SIX3 gene causes holoprosencephaly. Eur J Hum Genet 8(10):797\u2013800. \nhttps:\/\/doi.org\/10.1038\/sj.ejhg.5200540","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"1781_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/humu.20056","volume":"24","author":"C Dubourg","year":"2004","unstructured":"Dubourg C, Lazaro L, Pasquier L, Bendavid C, Blayau M, Le Duff F, Durou MR, Odent S et al (2004) Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: mutation review and genotype-phenotype correlations. Hum Mutat 24(1):43\u201351. \nhttps:\/\/doi.org\/10.1002\/humu.20056","journal-title":"Hum Mutat"},{"issue":"1","key":"1781_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.023416","volume":"42","author":"L Pasquier","year":"2005","unstructured":"Pasquier L, Dubourg C, Gonzales M, Lazaro L, David V, Odent S, Encha-Razavi F (2005) First occurrence of aprosencephaly\/atelencephaly and holoprosencephaly in a family with a SIX3 gene mutation and phenotype\/genotype correlation in our series of SIX3 mutations. J Med Genet 42(1):e4. \nhttps:\/\/doi.org\/10.1136\/jmg.2004.023416","journal-title":"J Med Genet"},{"issue":"1\u20132","key":"1781_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.mce.2013.06.026","volume":"377","author":"R Larder","year":"2013","unstructured":"Larder R, Kimura I, Meadows J, Clark DD, Mayo S, Mellon PL (2013) Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol 377(1\u20132):16\u201322. \nhttps:\/\/doi.org\/10.1016\/j.mce.2013.06.026","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"1781_CR9","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1210\/en.2014-1277","volume":"155","author":"HM Hoffmann","year":"2014","unstructured":"Hoffmann HM, Tamrazian A, Xie H, Perez-Millan MI, Kauffman AS, Mellon PL (2014) Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology 155(10):4043\u20134053. \nhttps:\/\/doi.org\/10.1210\/en.2014-1277","journal-title":"Endocrinology"},{"issue":"11","key":"1781_CR10","doi-asserted-by":"publisher","first-page":"8709","DOI":"10.1007\/s12035-018-1013-0","volume":"55","author":"EC Pandolfi","year":"2018","unstructured":"Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL (2018) Haploinsufficiency of SIX3 abolishes male reproductive behavior through disrupted olfactory development, and impairs female fertility through disrupted GnRH neuron migration. Mol Neurobiol 55(11):8709\u20138727. \nhttps:\/\/doi.org\/10.1007\/s12035-018-1013-0","journal-title":"Mol Neurobiol"},{"issue":"23","key":"1781_CR11","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.1242\/dev.132142","volume":"143","author":"X Geng","year":"2016","unstructured":"Geng X, Acosta S, Lagutin O, Gil H, Oliver G (2016) Six3 dosage mediates the pathogenesis of holoprosencephaly. Development 143(23):4462\u20134473. \nhttps:\/\/doi.org\/10.1242\/dev.132142","journal-title":"Development"},{"key":"1781_CR12","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000494086","volume":"109","author":"H Hoffmann","year":"2018","unstructured":"Hoffmann H, Pandolfi E, Larder R, Mellon P (2018) Haploinsufficiency of homeodomain proteins Six3, Vax1, and Otx2, causes subfertility in mice via distinct mechanisms. Neuroendocrinology 109:200\u2013207. \nhttps:\/\/doi.org\/10.1159\/000494086","journal-title":"Neuroendocrinology"},{"issue":"1","key":"1781_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.mce.2009.12.012","volume":"323","author":"SW Davis","year":"2010","unstructured":"Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, Brinkmeier ML, Raetzman LT et al (2010) Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol 323(1):4\u201319","journal-title":"Mol Cell Endocrinol"},{"key":"1781_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.mce.2016.09.031","volume":"438","author":"D Nesan","year":"2016","unstructured":"Nesan D, Kurrasch DM (2016) Genetic programs of the developing tuberal hypothalamus and potential mechanisms of their disruption by environmental factors. Mol Cell Endocrinol 438:3\u201317. \nhttps:\/\/doi.org\/10.1016\/j.mce.2016.09.031","journal-title":"Mol Cell Endocrinol"},{"issue":"16","key":"1781_CR15","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.1073\/pnas.0401149101","volume":"101","author":"M Sladek","year":"2004","unstructured":"Sladek M, Sumova A, Kovacikova Z, Bendova Z, Laurinova K, Illnerova H (2004) Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus. Proc Natl Acad Sci U S A 101(16):6231\u20136236. \nhttps:\/\/doi.org\/10.1073\/pnas.0401149101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6416","key":"1781_CR16","doi-asserted-by":"publisher","first-page":"eaau5324","DOI":"10.1126\/science.aau5324","volume":"362","author":"JR Moffitt","year":"2018","unstructured":"Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J et al (2018) Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region. Science 362(6416):eaau5324. \nhttps:\/\/doi.org\/10.1126\/science.aau5324","journal-title":"Science"},{"issue":"3","key":"1781_CR17","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.celrep.2014.03.060","volume":"7","author":"JL Bedont","year":"2014","unstructured":"Bedont JL, LeGates TA, Slat EA, Byerly MS, Wang H, Hu J, Rupp AC, Qian J et al (2014) Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Rep 7(3):609\u2013622. \nhttps:\/\/doi.org\/10.1016\/j.celrep.2014.03.060","journal-title":"Cell Rep"},{"issue":"5","key":"1781_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00360-010-0451-4","volume":"180","author":"E Challet","year":"2010","unstructured":"Challet E (2010) Interactions between light, mealtime and calorie restriction to control daily timing in mammals. J Comp Physiol B 180(5):631\u2013644. \nhttps:\/\/doi.org\/10.1007\/s00360-010-0451-4","journal-title":"J Comp Physiol B"},{"key":"1781_CR19","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/dom.12516","volume":"17 Suppl 1","author":"E Challet","year":"2015","unstructured":"Challet E (2015) Keeping circadian time with hormones. Diabetes Obes Metab 17 Suppl 1:76\u201383. \nhttps:\/\/doi.org\/10.1111\/dom.12516","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"1781_CR20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/0748730407311254","volume":"23","author":"JD Alvarez","year":"2008","unstructured":"Alvarez JD, Hansen A, Ord T, Bebas P, Chappell PE, Giebultowicz JM, Williams C, Moss S et al (2008) The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J Biol Rhythm 23(1):26\u201336. \nhttps:\/\/doi.org\/10.1177\/0748730407311254","journal-title":"J Biol Rhythm"},{"issue":"12","key":"1781_CR21","doi-asserted-by":"publisher","first-page":"E1132","DOI":"10.1073\/pnas.1217154110","volume":"110","author":"CS Moller-Levet","year":"2013","unstructured":"Moller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N et al (2013) Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A 110(12):E1132\u2013E1141. \nhttps:\/\/doi.org\/10.1073\/pnas.1217154110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"1781_CR22","doi-asserted-by":"publisher","first-page":"6457","DOI":"10.1523\/JNEUROSCI.5385-10.2011","volume":"31","author":"C VanDunk","year":"2011","unstructured":"VanDunk C, Hunter LA, Gray PA (2011) Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci 31(17):6457\u20136467. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.5385-10.2011","journal-title":"J Neurosci"},{"key":"1781_CR23","doi-asserted-by":"publisher","first-page":"813764","DOI":"10.1155\/2010\/813764","volume":"2010","author":"MM Mahoney","year":"2010","unstructured":"Mahoney MM (2010) Shift work, jet lag, and female reproduction. Int J Endocrinol 2010:813764. \nhttps:\/\/doi.org\/10.1155\/2010\/813764","journal-title":"Int J Endocrinol"},{"issue":"5","key":"1781_CR24","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/0748730414549767","volume":"29","author":"DH Loh","year":"2014","unstructured":"Loh DH, Kuljis DA, Azuma L, Wu Y, Truong D, Wang HB, Colwell CS (2014) Disrupted reproduction, estrous cycle, and circadian rhythms in female mice deficient in vasoactive intestinal peptide. J Biol Rhythm 29(5):355\u2013369. \nhttps:\/\/doi.org\/10.1177\/0748730414549767","journal-title":"J Biol Rhythm"},{"issue":"1","key":"1781_CR25","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1159\/000243163","volume":"91","author":"JR Hickok","year":"2010","unstructured":"Hickok JR, Tischkau SA (2010) In vivo circadian rhythms in gonadotropin-releasing hormone neurons. Neuroendocrinology 91(1):110\u2013120. \nhttps:\/\/doi.org\/10.1159\/000243163","journal-title":"Neuroendocrinology"},{"issue":"5","key":"1781_CR26","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1159\/000122944","volume":"29","author":"SS Mosko","year":"1979","unstructured":"Mosko SS, Moore RY (1979) Neonatal ablation of the suprachiasmatic nucleus. Effects on the development of the pituitary-gonadal axis in the female rat. Neuroendocrinology 29(5):350\u2013361","journal-title":"Neuroendocrinology"},{"issue":"6","key":"1781_CR27","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1210\/en.2007-1098","volume":"149","author":"CA Christian","year":"2008","unstructured":"Christian CA, Moenter SM (2008) Vasoactive intestinal polypeptide can excite gonadotropin-releasing hormone neurons in a manner dependent on estradiol and gated by time of day. Endocrinology 149(6):3130\u20133136","journal-title":"Endocrinology"},{"key":"1781_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fendo.2012.00060","volume":"3","author":"WP Williams 3rd","year":"2012","unstructured":"Williams WP 3rd, Kriegsfeld LJ (2012) Circadian control of neuroendocrine circuits regulating female reproductive function. Front Endocrinol 3:60. \nhttps:\/\/doi.org\/10.3389\/fendo.2012.00060","journal-title":"Front Endocrinol"},{"issue":"9","key":"1781_CR29","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1111\/j.1365-2826.2010.02045.x","volume":"22","author":"B Vida","year":"2010","unstructured":"Vida B, Deli L, Hrabovszky E, Kalamatianos T, Caraty A, Coen CW, Liposits Z, Kallo I (2010) Evidence for suprachiasmatic vasopressin neurones innervating kisspeptin neurones in the rostral periventricular area of the mouse brain: regulation by oestrogen. J Neuroendocrinol 22(9):1032\u20131039. \nhttps:\/\/doi.org\/10.1111\/j.1365-2826.2010.02045.x","journal-title":"J Neuroendocrinol"},{"issue":"7","key":"1781_CR30","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1210\/en.2014-1762","volume":"156","author":"KA Russo","year":"2015","unstructured":"Russo KA, La JL, Stephens SB, Poling MC, Padgaonkar NA, Jennings KJ, Piekarski DJ, Kauffman AS et al (2015) Circadian control of the female reproductive axis through gated responsiveness of the RFRP-3 system to VIP signaling. Endocrinology 156(7):2608\u20132618. \nhttps:\/\/doi.org\/10.1210\/en.2014-1762","journal-title":"Endocrinology"},{"issue":"12","key":"1781_CR31","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1111\/jne.12104","volume":"25","author":"BL Smarr","year":"2013","unstructured":"Smarr BL, Gile JJ, de la Iglesia HO (2013) Oestrogen-independent circadian clock gene expression in the anteroventral periventricular nucleus in female rats: possible role as an integrator for circadian and ovarian signals timing the luteinising hormone surge. J Neuroendocrinol 25(12):1273\u20131279. \nhttps:\/\/doi.org\/10.1111\/jne.12104","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"1781_CR32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1210\/en.2010-0943","volume":"152","author":"WP Williams 3rd","year":"2011","unstructured":"Williams WP 3rd, Jarjisian SG, Mikkelsen JD, Kriegsfeld LJ (2011) Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology 152(2):595\u2013606. \nhttps:\/\/doi.org\/10.1210\/en.2010-0943","journal-title":"Endocrinology"},{"issue":"12","key":"1781_CR33","doi-asserted-by":"publisher","first-page":"e12660","DOI":"10.1111\/jne.12660","volume":"30","author":"D Schafer","year":"2018","unstructured":"Schafer D, Kane G, Colledge WH, Piet R, Herbison AE (2018) Sex- and sub region-dependent modulation of arcuate kisspeptin neurones by vasopressin and vasoactive intestinal peptide. J Neuroendocrinol 30(12):e12660. \nhttps:\/\/doi.org\/10.1111\/jne.12660","journal-title":"J Neuroendocrinol"},{"issue":"9","key":"1781_CR34","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1210\/en.2016-1399","volume":"157","author":"R Piet","year":"2016","unstructured":"Piet R, Dunckley H, Lee K, Herbison AE (2016) Vasoactive intestinal peptide excites GnRH neurons in male and female mice. Endocrinology 157(9):3621\u20133630. \nhttps:\/\/doi.org\/10.1210\/en.2016-1399","journal-title":"Endocrinology"},{"issue":"17","key":"1781_CR35","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1523\/JNEUROSCI.4587-14.2015","volume":"35","author":"R Piet","year":"2015","unstructured":"Piet R, Fraissenon A, Boehm U, Herbison AE (2015) Estrogen permits vasopressin signaling in preoptic kisspeptin neurons in the female mouse. J Neurosci 35(17):6881\u20136892. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.4587-14.2015","journal-title":"J Neurosci"},{"key":"1781_CR36","first-page":"95","volume-title":"The GnRH neuron and its control","author":"HM Hoffmann","year":"2018","unstructured":"Hoffmann HM, Mellon PL (2018) Regulation of GnRH gene expression. In: Herbison AE, Plant TM (eds) The GnRH neuron and its control. Wiley Blackwell, Hoboken, pp. 95\u2013120"},{"issue":"5","key":"1781_CR37","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/wdev.187","volume":"4","author":"JL Bedont","year":"2015","unstructured":"Bedont JL, Newman EA, Blackshaw S (2015) Patterning, specification, and differentiation in the developing hypothalamus. Wiley Interdiscip Rev Dev Biol 4(5):445\u2013468. \nhttps:\/\/doi.org\/10.1002\/wdev.187","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"35","key":"1781_CR38","doi-asserted-by":"publisher","first-page":"11202","DOI":"10.1523\/JNEUROSCI.23-35-11202.2003","volume":"23","author":"PE Chappell","year":"2003","unstructured":"Chappell PE, White RS, Mellon PL (2003) Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci 23(35):11202\u201311213","journal-title":"J Neurosci"},{"key":"1781_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.yfrne.2014.09.004","volume":"36","author":"PE Forni","year":"2015","unstructured":"Forni PE, Wray S (2015) GnRH, anosmia and hypogonadotropic hypogonadism--where are we? Front Neuroendocrinol 36:165\u2013177. \nhttps:\/\/doi.org\/10.1016\/j.yfrne.2014.09.004","journal-title":"Front Neuroendocrinol"},{"issue":"23","key":"1781_CR40","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1101\/gad.13.23.3106","volume":"13","author":"M Hallonet","year":"1999","unstructured":"Hallonet M, Hollemann T, Pieler T, Gruss P (1999) Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev 13(23):3106\u20133114","journal-title":"Genes Dev"},{"issue":"23","key":"1781_CR41","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1101\/gad.13.23.3092","volume":"13","author":"S Bertuzzi","year":"1999","unstructured":"Bertuzzi S, Hindges R, Mui SH, O'Leary DD, Lemke G (1999) The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev 13(23):3092\u20133105","journal-title":"Genes Dev"},{"key":"1781_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-71301-9_1","volume":"100","author":"J Altman","year":"1986","unstructured":"Altman J, Bayer SA (1986) The development of the rat hypothalamus. Adv Anat Embryol Cell Biol 100:1\u2013178","journal-title":"Adv Anat Embryol Cell Biol"},{"issue":"2","key":"1781_CR43","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1523\/JNEUROSCI.1688-10.2011","volume":"31","author":"R Larder","year":"2011","unstructured":"Larder R, Clark DD, Miller NL, Mellon PL (2011) Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci 31(2):426\u2013438. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.1688-10.2011","journal-title":"J Neurosci"},{"issue":"1","key":"1781_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/0748730412468084","volume":"28","author":"DD Clark","year":"2013","unstructured":"Clark DD, Gorman MR, Hatori M, Meadows JD, Panda S, Mellon PL (2013) Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein six6. J Biol Rhythm 28(1):15\u201325. \nhttps:\/\/doi.org\/10.1177\/0748730412468084","journal-title":"J Biol Rhythm"},{"key":"1781_CR45","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1210\/en.2019-00113","volume":"160","author":"EC Pandolfi","year":"2019","unstructured":"Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL (2019) Deletion of the homeodomain protein Six6 from GnRH neurons decreases GnRH gene expression resulting in infertility. Endocrinology 160:2151\u20132164. \nhttps:\/\/doi.org\/10.1210\/en.2019-00113","journal-title":"Endocrinology"},{"issue":"12","key":"1781_CR46","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1523\/JNEUROSCI.2723-15.2016","volume":"36","author":"HM Hoffmann","year":"2016","unstructured":"Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, Mellon PL (2016) Deletion of Vax1 from GnRH neurons abolishes GnRH expression and leads to hypogonadism and infertility. J Neurosci 36(12):3506\u20133518. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.2723-15.2016","journal-title":"J Neurosci"},{"issue":"5","key":"1781_CR47","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1242\/dev.056465","volume":"138","author":"K Bharti","year":"2011","unstructured":"Bharti K, Gasper M, Bertuzzi S, Arnheiter H (2011) Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development 138(5):873\u2013878. \nhttps:\/\/doi.org\/10.1242\/dev.056465","journal-title":"Development"},{"issue":"4","key":"1781_CR48","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2005.08.039","volume":"123","author":"H Yoon","year":"2005","unstructured":"Yoon H, Enquist LW, Dulac C (2005) Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell 123(4):669\u2013682","journal-title":"Cell"},{"issue":"7","key":"1781_CR49","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1111\/j.1365-2826.2008.01746.x","volume":"20","author":"A Wolfe","year":"2008","unstructured":"Wolfe A, Divall S, Singh SP, Nikrodhanond AA, Baria AT, Le WW, Hoffman GE, Radovick S (2008) Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse. J Neuroendocrinol 20(7):909\u2013916","journal-title":"J Neuroendocrinol"},{"issue":"6\u20137","key":"1781_CR50","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.visres.2005.09.006","volume":"46","author":"WH Ridder 3rd","year":"2006","unstructured":"Ridder WH 3rd, Nusinowitz S (2006) The visual evoked potential in the mouse--origins and response characteristics. Vis Res 46(6\u20137):902\u2013913. \nhttps:\/\/doi.org\/10.1016\/j.visres.2005.09.006","journal-title":"Vis Res"},{"key":"1781_CR51","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.mce.2017.09.004","volume":"461","author":"HM Hoffmann","year":"2018","unstructured":"Hoffmann HM, Gong P, Tamrazian A, Mellon PL (2018) Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143\u2013154. \nhttps:\/\/doi.org\/10.1016\/j.mce.2017.09.004","journal-title":"Mol Cell Endocrinol"},{"key":"1781_CR52","doi-asserted-by":"publisher","first-page":"e03357","DOI":"10.7554\/eLife.03357","volume":"3","author":"M Hatori","year":"2014","unstructured":"Hatori M, Gill S, Mure LS, Goulding M, O'Leary DD, Panda S (2014) Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. eLife 3:e03357. \nhttps:\/\/doi.org\/10.7554\/eLife.03357","journal-title":"eLife"},{"issue":"19","key":"1781_CR53","doi-asserted-by":"publisher","first-page":"19156","DOI":"10.1074\/jbc.M502004200","volume":"280","author":"ML Givens","year":"2005","unstructured":"Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B et al (2005) Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem 280(19):19156\u201319165","journal-title":"J Biol Chem"},{"key":"1781_CR54","doi-asserted-by":"publisher","unstructured":"Hoffmann HM (2018) Determination of reproductive competence by confirming pubertal onset and performing a fertility assay in mice and rats. J Vis Exp (140):e58352. doi:\nhttps:\/\/doi.org\/10.3791\/58352","DOI":"10.3791\/58352"},{"key":"1781_CR55","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1159\/000497791","volume":"108","author":"HM Hoffmann","year":"2019","unstructured":"Hoffmann HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL (2019) Differential CRE expression in Lhrh-Cre and Gnrh-Cre alleles and the impact on fertility in Otx2-flox mice. Neuroendocrinology 108:328\u2013342. \nhttps:\/\/doi.org\/10.1159\/000497791","journal-title":"Neuroendocrinology"},{"issue":"6","key":"1781_CR56","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1242\/dev.014142","volume":"135","author":"K Bharti","year":"2008","unstructured":"Bharti K, Liu W, Csermely T, Bertuzzi S, Arnheiter H (2008) Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169\u20131178. \nhttps:\/\/doi.org\/10.1242\/dev.014142","journal-title":"Development"},{"key":"1781_CR57","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3389\/fnsys.2015.00074","volume":"9","author":"JL Bedont","year":"2015","unstructured":"Bedont JL, Blackshaw S (2015) Constructing the suprachiasmatic nucleus: a watchmaker\u2019s perspective on the central clockworks. Front Syst Neurosci 9:74. \nhttps:\/\/doi.org\/10.3389\/fnsys.2015.00074","journal-title":"Front Syst Neurosci"},{"issue":"11","key":"1781_CR58","doi-asserted-by":"publisher","first-page":"e50426","DOI":"10.1371\/journal.pone.0050426","volume":"7","author":"TF Plageman Jr","year":"2012","unstructured":"Plageman TF Jr, Lang RA (2012) Generation of an Rx-tTA: TetOp-Cre knock-in mouse line for doxycycline regulated Cre activity in the Rx expression domain. PLoS One 7(11):e50426. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0050426","journal-title":"PLoS One"},{"issue":"5","key":"1781_CR59","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3109\/07420528.2014.885528","volume":"31","author":"MS Blattner","year":"2014","unstructured":"Blattner MS, Mahoney MM (2014) Estrogen receptor 1 modulates circadian rhythms in adult female mice. Chronobiol Int 31(5):637\u2013644. \nhttps:\/\/doi.org\/10.3109\/07420528.2014.885528","journal-title":"Chronobiol Int"},{"issue":"1","key":"1781_CR60","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.yfrne.2013.11.003","volume":"35","author":"M Bailey","year":"2014","unstructured":"Bailey M, Silver R (2014) Sex differences in circadian timing systems: implications for disease. Front Neuroendocrinol 35(1):111\u2013139. \nhttps:\/\/doi.org\/10.1016\/j.yfrne.2013.11.003","journal-title":"Front Neuroendocrinol"},{"issue":"2","key":"1781_CR61","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0031-9384(91)90080-8","volume":"50","author":"DM Edgar","year":"1991","unstructured":"Edgar DM, Kilduff TS, Martin CE, Dement WC (1991) Influence of running wheel activity on free-running sleep\/wake and drinking circadian rhythms in mice. Physiol Behav 50(2):373\u2013378","journal-title":"Physiol Behav"},{"issue":"4","key":"1781_CR62","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1210\/js.2018-00228","volume":"3","author":"KJ Tonsfeldt","year":"2019","unstructured":"Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui LJ, Lee J, Mellon PL (2019) The contribution of the circadian gene Bmal1 to female fertility and the generation of the preovulatory luteinizing hormone surge. J Endocr Soc 3(4):716\u2013733. \nhttps:\/\/doi.org\/10.1210\/js.2018-00228","journal-title":"J Endocr Soc"},{"key":"1781_CR63","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-neuro-071714-034120","volume":"38","author":"JR Sanes","year":"2015","unstructured":"Sanes JR, Masland RH (2015) The types of retinal ganglion cells: current status and implications for neuronal classification. Annu Rev Neurosci 38:221\u2013246. \nhttps:\/\/doi.org\/10.1146\/annurev-neuro-071714-034120","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"1781_CR64","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1152\/japplphysiol.00836.2001","volume":"92","author":"ED Herzog","year":"2002","unstructured":"Herzog ED, Schwartz WJ (2002) A neural clockwork for encoding circadian time. J Appl Physiol 92(1):401\u2013408. \nhttps:\/\/doi.org\/10.1152\/japplphysiol.00836.2001","journal-title":"J Appl Physiol"},{"issue":"1","key":"1781_CR65","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0165-3806(82)90172-9","volume":"282","author":"WJ Crossland","year":"1982","unstructured":"Crossland WJ, Uchwat CJ (1982) Neurogenesis in the chick ventral lateral geniculate and ectomammillary nuclei: relationship of soma size to birthdate. Brain Res 282(1):33\u201346","journal-title":"Brain Res"},{"key":"1781_CR66","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.brainres.2007.12.020","volume":"1195","author":"CS Kabrita","year":"2008","unstructured":"Kabrita CS, Davis FC (2008) Development of the mouse suprachiasmatic nucleus: determination of time of cell origin and spatial arrangements within the nucleus. Brain Res 1195:20\u201327. \nhttps:\/\/doi.org\/10.1016\/j.brainres.2007.12.020","journal-title":"Brain Res"},{"issue":"11","key":"1781_CR67","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1136\/jnnp.54.11.945","volume":"54","author":"A Compston","year":"1991","unstructured":"Compston A (1991) Limiting and repairing the damage in multiple sclerosis. J Neurol Neurosurg Psychiatry 54(11):945\u2013948","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"1781_CR68","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/(SICI)1096-9861(19970811)384:4<569::AID-CNE6>3.0.CO;2-0","volume":"384","author":"EM van der Beek","year":"1997","unstructured":"van der Beek EM, Horvath TL, Wiegant VM, van den Hurk R, Buijs RM (1997) Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin-releasing hormone system: combined tracing and light and electron microscopic immunocytochemical studies. J Comp Neurol 384(4):569\u2013579","journal-title":"J Comp Neurol"},{"issue":"1\u20132","key":"1781_CR69","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0006-8993(98)00208-X","volume":"795","author":"TL Horvath","year":"1998","unstructured":"Horvath TL, Cela V, van der Beek EM (1998) Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat. Brain Res 795(1\u20132):277\u2013281","journal-title":"Brain Res"},{"issue":"9","key":"1781_CR70","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1046\/j.1365-2826.2002.00818.x","volume":"14","author":"LJ Kriegsfeld","year":"2002","unstructured":"Kriegsfeld LJ, Silver R, Gore AC, Crews D (2002) Vasoactive intestinal polypeptide contacts on gonadotropin-releasing hormone neurones increase following puberty in female rats. J Neuroendocrinol 14(9):685\u2013690","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"1781_CR71","doi-asserted-by":"publisher","first-page":"e5322","DOI":"10.1371\/journal.pone.0005322","volume":"4","author":"DR Ward","year":"2009","unstructured":"Ward DR, Dear FM, Ward IA, Anderson SI, Spergel DJ, Smith PA, Ebling FJ (2009) Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse. PLoS One 4(4):e5322. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0005322","journal-title":"PLoS One"},{"issue":"6","key":"1781_CR72","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1210\/en.2011-1857","volume":"153","author":"BL Smarr","year":"2012","unstructured":"Smarr BL, Morris E, de la Iglesia HO (2012) The dorsomedial suprachiasmatic nucleus times circadian expression of Kiss1 and the luteinizing hormone surge. Endocrinology 153(6):2839\u20132850. \nhttps:\/\/doi.org\/10.1210\/en.2011-1857","journal-title":"Endocrinology"},{"issue":"11","key":"1781_CR73","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1210\/endo.141.11.7876","volume":"141","author":"MJ Smith","year":"2000","unstructured":"Smith MJ, Jiennes L, Wise PM (2000) Localization of the VIP2 receptor protein on GnRH neurons in the female rat. Endocrinology 141(11):4317\u20134320. \nhttps:\/\/doi.org\/10.1210\/endo.141.11.7876","journal-title":"Endocrinology"},{"issue":"1","key":"1781_CR74","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1093\/humrep\/dei313","volume":"21","author":"H Dolatshad","year":"2006","unstructured":"Dolatshad H, Campbell EA, O'Hara L, Maywood ES, Hastings MH, Johnson MH (2006) Developmental and reproductive performance in circadian mutant mice. Hum Reprod 21(1):68\u201379. \nhttps:\/\/doi.org\/10.1093\/humrep\/dei313","journal-title":"Hum Reprod"},{"issue":"1","key":"1781_CR75","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1210\/endo-96-1-57","volume":"96","author":"SJ Legan","year":"1975","unstructured":"Legan SJ, Karsch FJ (1975) A daily signal for the LH surge in the rat. Endocrinology 96(1):57\u201362","journal-title":"Endocrinology"},{"issue":"4","key":"1781_CR76","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1210\/er.2009-0023","volume":"31","author":"CA Christian","year":"2010","unstructured":"Christian CA, Moenter SM (2010) The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges. Endocr Rev 31(4):544\u2013577. \nhttps:\/\/doi.org\/10.1210\/er.2009-0023","journal-title":"Endocr Rev"},{"issue":"14","key":"1781_CR77","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1242\/dev.045294","volume":"137","author":"I Conte","year":"2010","unstructured":"Conte I, Marco-Ferreres R, Beccari L, Cisneros E, Ruiz JM, Tabanera N, Bovolenta P (2010) Proper differentiation of photoreceptors and amacrine cells depends on a regulatory loop between NeuroD and Six6. Development 137(14):2307\u20132317. \nhttps:\/\/doi.org\/10.1242\/dev.045294","journal-title":"Development"},{"issue":"2","key":"1781_CR78","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ydbio.2008.12.022","volume":"327","author":"N Tetreault","year":"2009","unstructured":"Tetreault N, Champagne MP, Bernier G (2009) The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. Dev Biol 327(2):541\u2013550. \nhttps:\/\/doi.org\/10.1016\/j.ydbio.2008.12.022","journal-title":"Dev Biol"},{"issue":"5","key":"1781_CR79","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1210\/me.2010-0271","volume":"25","author":"D Diaczok","year":"2011","unstructured":"Diaczok D, DiVall S, Matsuo I, Wondisford FE, Wolfe AM, Radovick S (2011) Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism. Mol Endocrinol 25(5):833\u2013846. \nhttps:\/\/doi.org\/10.1210\/me.2010-0271","journal-title":"Mol Endocrinol"},{"issue":"9","key":"1781_CR80","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1210\/en.2016-1087","volume":"157","author":"JR Kurian","year":"2016","unstructured":"Kurian JR, Louis S, Keen KL, Wolfe A, Terasawa E, Levine JE (2016) The methylcytosine dioxygenase ten-eleven translocase-2 (tet2) enables elevated GnRH gene expression and maintenance of male reproductive function. Endocrinology 157(9):3588\u20133603. \nhttps:\/\/doi.org\/10.1210\/en.2016-1087","journal-title":"Endocrinology"},{"issue":"3","key":"1781_CR81","doi-asserted-by":"publisher","first-page":"e0119995","DOI":"10.1371\/journal.pone.0119995","volume":"10","author":"SA DiVall","year":"2015","unstructured":"DiVall SA, Herrera D, Sklar B, Wu S, Wondisford F, Radovick S, Wolfe A (2015) Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice. PLoS One 10(3):e0119995. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0119995","journal-title":"PLoS One"},{"issue":"2","key":"1781_CR82","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1210\/me.2013-1319","volume":"28","author":"HJ Novaira","year":"2014","unstructured":"Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S (2014) Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Mol Endocrinol 28(2):225\u2013238. \nhttps:\/\/doi.org\/10.1210\/me.2013-1319","journal-title":"Mol Endocrinol"},{"issue":"1","key":"1781_CR83","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1523\/JNEUROSCI.2974-10.2011","volume":"31","author":"S Wu","year":"2011","unstructured":"Wu S, Divall S, Hoffman GE, Le WW, Wagner KU, Wolfe A (2011) Jak2 is necessary for neuroendocrine control of female reproduction. J Neurosci 31(1):184\u2013192","journal-title":"J Neurosci"},{"issue":"8","key":"1781_CR84","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1172\/JCI41069","volume":"120","author":"SA Divall","year":"2010","unstructured":"Divall SA, Williams TR, Carver SE, Koch L, Bruning JC, Kahn CR, Wondisford F, Radovick S et al (2010) Divergent roles of growth factors in the GnRH regulation of puberty in mice. J Clin Invest 120(8):2900\u20132909. \nhttps:\/\/doi.org\/10.1172\/JCI41069","journal-title":"J Clin Invest"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01781-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-01781-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01781-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T01:12:31Z","timestamp":1604797951000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-01781-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,9]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1781"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-01781-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,9]]},"assertion":[{"value":"2 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}