{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:01:13Z","timestamp":1790949673025,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008436","name":"Ernst und Berta Grimmke Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s12035-019-01786-4","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T02:03:03Z","timestamp":1573264983000},"page":"1186-1202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intravitreal S100B Injection Triggers a Time-Dependent Microglia Response in a Pro-Inflammatory Manner in Retina and Optic Nerve"],"prefix":"10.1007","volume":"57","author":[{"given":"Pia","family":"Grotegut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kuehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Mei\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Burkhard","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-0829","authenticated-orcid":false,"given":"Stephanie C.","family":"Joachim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,9]]},"reference":[{"issue":"4","key":"1786_CR1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","volume":"40","author":"RJ Casson","year":"2012","unstructured":"Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I (2012) Definition of glaucoma: clinical and experimental concepts. Clin Exp Ophthalmol 40(4):341\u2013349","journal-title":"Clin Exp Ophthalmol"},{"issue":"5","key":"1786_CR2","first-page":"6110","volume":"51","author":"FH Grus","year":"2010","unstructured":"Grus FH, Boehm N, Beck S, Schlich M, Lossbrandt U, Pfeiffer N (2010) Autoantibody profiles in tear fluid as a diagnostic tool in glaucoma. Invest Ophthalmol Vis Sci 51(5):6110","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1786_CR3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/ceo.12864","volume":"45","author":"K Lorenz","year":"2017","unstructured":"Lorenz K, Beck S, Keilani MM, Wasielica-Poslednik J, Pfeiffer N, Grus FH (2017) Course of serum autoantibodies in patients after acute angle-closure glaucoma attack. Clin Exp Ophthalmol 45(3):280\u2013287","journal-title":"Clin Exp Ophthalmol"},{"issue":"2","key":"1786_CR4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0161-6420(00)00525-X","volume":"108","author":"MB Wax","year":"2001","unstructured":"Wax MB, Tezel G, Kawase K, Kitazawa Y (2001) Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States. Ophthalmology. 108(2):296\u2013302","journal-title":"Ophthalmology."},{"issue":"4","key":"1786_CR5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1001\/archopht.118.4.511","volume":"118","author":"G Tezel","year":"2000","unstructured":"Tezel G, Hernandez R, Wax MB (2000) Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol 118(4):511\u2013518","journal-title":"Arch Ophthalmol"},{"issue":"15","key":"1786_CR6","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.2174\/0929867323666160406121117","volume":"23","author":"ZZ Chong","year":"2016","unstructured":"Chong ZZ, Changyaleket B, Xu H, Dull RO, Schwartz DE (2016) Identifying S100B as a biomarker and a therapeutic target for brain injury and multiple diseases. Curr Med Chem 23(15):1571\u20131596","journal-title":"Curr Med Chem"},{"issue":"1","key":"1786_CR7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0021-5155(02)00627-5","volume":"47","author":"M Sakai","year":"2003","unstructured":"Sakai M, Sakai H, Nakamura Y, Fukuchi T, Sawaguchi S (2003) Immunolocalization of heat shock proteins in the retina of normal monkey eyes and monkey eyes with laser-induced glaucoma. Jpn J Ophthalmol 47(1):42\u201352","journal-title":"Jpn J Ophthalmol"},{"issue":"1","key":"1786_CR8","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/s41467-018-05681-9","volume":"9","author":"H Chen","year":"2018","unstructured":"Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML et al (2018) Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun 9(1):3209","journal-title":"Nat Commun"},{"issue":"46","key":"1786_CR9","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1523\/JNEUROSCI.3200-08.2008","volume":"28","author":"MB Wax","year":"2008","unstructured":"Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ (2008) Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci 28(46):12085\u201312096","journal-title":"J Neurosci"},{"issue":"10","key":"1786_CR10","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1167\/iovs.08-3144","volume":"50","author":"SC Joachim","year":"2009","unstructured":"Joachim SC, Grus FH, Kraft D, White-Farrar K, Barnes G, Barbeck M, Ghanaati S, Cao S et al (2009) Complex antibody profile changes in an experimental autoimmune glaucoma animal model. Invest Ophthalmol Vis Sci 50(10):4734\u20134742","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"1786_CR11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/pro.5560040416","volume":"4","author":"C Donaldson","year":"1995","unstructured":"Donaldson C, Barber KR, Kay CM, Shaw GS (1995) Human S100b protein: formation of a tetramer from synthetic calcium-binding site peptides. Protein Sci 4(4):765\u2013772","journal-title":"Protein Sci"},{"issue":"6","key":"1786_CR12","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.bbamcr.2008.11.009","volume":"1793","author":"R Donato","year":"2009","unstructured":"Donato R, Sorci G, Riuzzi F, Arcuri C, Bianchi R, Brozzi F, Tubaro C, Giambanco I (2009) S100B\u2019s double life: intracellular regulator and extracellular signal. Biochim Biophys Acta 1793(6):1008\u20131022","journal-title":"Biochim Biophys Acta"},{"key":"1786_CR13","doi-asserted-by":"crossref","first-page":"1):1","DOI":"10.4331\/wjbc.v4.i1.1","volume":"4","author":"G Sorci","year":"2013","unstructured":"Sorci G, Riuzzi F, Arcuri C, Tubaro C, Bianchi R, Giambanco I et al (2013) S100B protein in tissue development, repair and regeneration. World J Biol Chem 4:1):1\u20131)12","journal-title":"World J Biol Chem"},{"key":"1786_CR14","first-page":"d1356","volume":"7","author":"CW Heizmann","year":"2002","unstructured":"Heizmann CW, Fritz G, Schafer BW (2002) S100 proteins: structure, functions and pathology. Front Biosci 7:d1356\u2013d1368","journal-title":"Front Biosci"},{"issue":"9","key":"1786_CR15","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1074\/jbc.M110.169342","volume":"286","author":"R Bianchi","year":"2011","unstructured":"Bianchi R, Kastrisianaki E, Giambanco I, Donato R (2011) S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release. J Biol Chem 286(9):7214\u20137226","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"1786_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3940(87)90696-3","volume":"79","author":"PL McGeer","year":"1987","unstructured":"McGeer PL, Itagaki S, Tago H, McGeer EG (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett 79(1\u20132):195\u2013200","journal-title":"Neurosci Lett"},{"issue":"6","key":"1786_CR17","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1007\/s12035-015-9336-6","volume":"53","author":"A Barateiro","year":"2016","unstructured":"Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A (2016) S100B as a potential biomarker and therapeutic target in multiple sclerosis. Mol Neurobiol 53(6):3976\u20133991","journal-title":"Mol Neurobiol"},{"issue":"2","key":"1786_CR18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1471-4159.2011.07207.x","volume":"117","author":"A Villarreal","year":"2011","unstructured":"Villarreal A, Aviles Reyes RX, Angelo MF, Reines AG, Ramos AJ (2011) S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-kappaB signaling. J Neurochem 117(2):321\u2013332","journal-title":"J Neurochem"},{"issue":"7","key":"1786_CR19","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1167\/iovs.11-9101","volume":"53","author":"G Tezel","year":"2012","unstructured":"Tezel G, Yang X, Luo C, Cai J, Powell DW (2012) An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma. Invest Ophthalmol Vis Sci 53(7):4220\u20134233","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"1786_CR20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12031-014-0485-2","volume":"56","author":"C Casola","year":"2015","unstructured":"Casola C, Schiwek JE, Reinehr S, Kuehn S, Grus FH, Kramer M, Dick HB, Joachim SC (2015) S100 alone has the same destructive effect on retinal ganglion cells as in combination with HSP 27 in an autoimmune glaucoma model. J Mol Neurosci 56(1):228\u2013236","journal-title":"J Mol Neurosci"},{"issue":"1","key":"1786_CR21","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1038\/s41598-018-28183-6","volume":"8","author":"S Reinehr","year":"2018","unstructured":"Reinehr S, Reinhard J, Gandej M, Gottschalk I, Stute G, Faissner A, Dick HB, Joachim SC (2018) S100B immunization triggers NFkappaB and complement activation in an autoimmune glaucoma model. Sci Rep 8(1):9821","journal-title":"Sci Rep"},{"issue":"13","key":"1786_CR22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.micinf.2004.08.004","volume":"6","author":"T Chavakis","year":"2004","unstructured":"Chavakis T, Bierhaus A, Nawroth PP (2004) RAGE (receptor for advanced glycation end products): a central player in the inflammatory response. Microbes Infect 6(13):1219\u20131225","journal-title":"Microbes Infect"},{"issue":"1\u20132","key":"1786_CR23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jneuroim.2006.12.011","volume":"184","author":"G Ponath","year":"2007","unstructured":"Ponath G, Schettler C, Kaestner F, Voigt B, Wentker D, Arolt V et al (2007) Autocrine S100B effects on astrocytes are mediated via RAGE. J Neuroimmunol 184(1\u20132):214\u2013222","journal-title":"J Neuroimmunol"},{"key":"1786_CR24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neubiorev.2015.12.006","volume":"62","author":"R Ray","year":"2016","unstructured":"Ray R, Juranek JK, Rai V (2016) RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis. Neurosci Biobehav Rev 62:48\u201355","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"1786_CR25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2174\/1570159X12999140829152550","volume":"12","author":"L Peng","year":"2014","unstructured":"Peng L, Parpura V, Verkhratsky A (2014) EDITORIAL neuroglia as a central element of neurological diseases: an underappreciated target for therapeutic intervention. Curr Neuropharmacol 12(4):303\u2013307","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"1786_CR26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","volume":"36","author":"Y Dong","year":"2001","unstructured":"Dong Y, Benveniste EN (2001) Immune function of astrocytes. Glia. 36(2):180\u2013190","journal-title":"Glia."},{"issue":"3","key":"1786_CR27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.it.2007.01.005","volume":"28","author":"C Farina","year":"2007","unstructured":"Farina C, Aloisi F, Meinl E (2007) Astrocytes are active players in cerebral innate immunity. Trends Immunol 28(3):138\u2013145","journal-title":"Trends Immunol"},{"issue":"5","key":"1786_CR28","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2337\/diabetes.47.5.815","volume":"47","author":"E Lieth","year":"1998","unstructured":"Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D, Strother JM (1998) Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes. 47(5):815\u2013820","journal-title":"Diabetes."},{"issue":"2","key":"1786_CR29","first-page":"431","volume":"41","author":"EC Johnson","year":"2000","unstructured":"Johnson EC, Deppmeier LM, Wentzien SK, Hsu I, Morrison JC (2000) Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest Ophthalmol Vis Sci 41(2):431\u2013442","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1786_CR30","doi-asserted-by":"crossref","first-page":"2954721","DOI":"10.1155\/2016\/2954721","volume":"2016","author":"R de Hoz","year":"2016","unstructured":"de Hoz R, Rojas B, Ramirez AI, Salazar JJ, Gallego BI, Trivino A et al (2016) Retinal macroglial responses in health and disease. Biomed Res Int 2016:2954721","journal-title":"Biomed Res Int"},{"key":"1786_CR31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainresbull.2017.02.001","volume":"136","author":"E Dossi","year":"2018","unstructured":"Dossi E, Vasile F, Rouach N (2018) Human astrocytes in the diseased brain. Brain Res Bull 136:139\u2013156","journal-title":"Brain Res Bull"},{"issue":"1","key":"1786_CR32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/glia.22738","volume":"63","author":"SH Chen","year":"2015","unstructured":"Chen SH, Oyarzabal EA, Sung YF, Chu CH, Wang Q, Chen SL, Lu RB, Hong JS (2015) Microglial regulation of immunological and neuroprotective functions of astroglia. Glia. 63(1):118\u2013131","journal-title":"Glia."},{"issue":"2","key":"1786_CR33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/glia.1106","volume":"36","author":"F Aloisi","year":"2001","unstructured":"Aloisi F (2001) Immune function of microglia. Glia. 36(2):165\u2013179","journal-title":"Glia."},{"issue":"2","key":"1786_CR34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/glia.10154","volume":"40","author":"WJ Streit","year":"2002","unstructured":"Streit WJ (2002) Microglia as neuroprotective, immunocompetent cells of the CNS. Glia. 40(2):133\u2013139","journal-title":"Glia."},{"issue":"3","key":"1786_CR35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/jnr.20562","volume":"81","author":"SU Kim","year":"2005","unstructured":"Kim SU, de Vellis J (2005) Microglia in health and disease. J Neurosci Res 81(3):302\u2013313","journal-title":"J Neurosci Res"},{"key":"1786_CR36","first-page":"480739","volume":"2013","author":"G Ramesh","year":"2013","unstructured":"Ramesh G, MacLean AG, Philipp MT (2013) Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain. Mediat Inflamm 2013:480739","journal-title":"Mediat Inflamm"},{"key":"1786_CR37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fncel.2018.00312","volume":"12","author":"S Kuehn","year":"2018","unstructured":"Kuehn S, Meissner W, Grotegut P, Theiss C, Dick HB, Joachim SC (2018) Intravitreal S100B injection leads to progressive glaucoma like damage in retina and optic nerve. Front Cell Neurosci 12:312","journal-title":"Front Cell Neurosci"},{"issue":"3\u20134","key":"1786_CR38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12031-017-0978-x","volume":"63","author":"S Kuehn","year":"2017","unstructured":"Kuehn S, Rodust C, Stute G, Grotegut P, Meissner W, Reinehr S et al (2017) Concentration-dependent inner retina layer damage and optic nerve degeneration in a NMDA model. J Mol Neurosci 63(3\u20134):283\u2013299","journal-title":"J Mol Neurosci"},{"issue":"4","key":"1786_CR39","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s12031-015-0707-2","volume":"58","author":"R Noristani","year":"2016","unstructured":"Noristani R, Kuehn S, Stute G, Reinehr S, Stellbogen M, Dick HB, Joachim SC (2016) Retinal and optic nerve damage is associated with early glial responses in an experimental autoimmune glaucoma model. J Mol Neurosci 58(4):470\u2013482","journal-title":"J Mol Neurosci"},{"issue":"7","key":"1786_CR40","doi-asserted-by":"crossref","first-page":"e40616","DOI":"10.1371\/journal.pone.0040616","volume":"7","author":"SC Joachim","year":"2012","unstructured":"Joachim SC, Gramlich OW, Laspas P, Schmid H, Beck S, von Pein HD, Dick HB, Pfeiffer N et al (2012) Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens. PLoS One 7(7):e40616","journal-title":"PLoS One"},{"key":"1786_CR41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1742-2094-10-120","volume":"10","author":"L Horstmann","year":"2013","unstructured":"Horstmann L, Schmid H, Heinen AP, Kurschus FC, Dick HB, Joachim SC (2013) Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model. J Neuroinflammation 10:120","journal-title":"J Neuroinflammation"},{"issue":"5","key":"1786_CR42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/1352458506070629","volume":"12","author":"KS Shindler","year":"2006","unstructured":"Shindler KS, Guan Y, Ventura E, Bennett J, Rostami A (2006) Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Mult Scler 12(5):526\u2013532","journal-title":"Mult Scler"},{"issue":"4","key":"1786_CR43","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neurobiolaging.2008.05.017","volume":"31","author":"R Bianchi","year":"2010","unstructured":"Bianchi R, Giambanco I, Donato R (2010) S100B\/RAGE-dependent activation of microglia via NF-kappaB and AP-1 co-regulation of COX-2 expression by S100B, IL-1beta and TNF-alpha. Neurobiol Aging 31(4):665\u2013677","journal-title":"Neurobiol Aging"},{"issue":"2","key":"1786_CR44","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4049\/jimmunol.153.2.712","volume":"153","author":"JP Cogswell","year":"1994","unstructured":"Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP et al (1994) NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J Immunol 153(2):712\u2013723","journal-title":"J Immunol"},{"issue":"4","key":"1786_CR45","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.neuroscience.2006.05.008","volume":"141","author":"R Gerlach","year":"2006","unstructured":"Gerlach R, Demel G, Konig HG, Gross U, Prehn JH, Raabe A et al (2006) Active secretion of S100B from astrocytes during metabolic stress. Neuroscience. 141(4):1697\u20131701","journal-title":"Neuroscience."},{"issue":"6","key":"1786_CR46","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1471-4159.2007.04515.x","volume":"101","author":"EF Ellis","year":"2007","unstructured":"Ellis EF, Willoughby KA, Sparks SA, Chen T (2007) S100B protein is released from rat neonatal neurons, astrocytes, and microglia by in vitro trauma and anti-S100 increases trauma-induced delayed neuronal injury and negates the protective effect of exogenous S100B on neurons. J Neurochem 101(6):1463\u20131470","journal-title":"J Neurochem"},{"issue":"2","key":"1786_CR47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/glia.20184","volume":"51","author":"S Hachem","year":"2005","unstructured":"Hachem S, Aguirre A, Vives V, Marks A, Gallo V, Legraverend C (2005) Spatial and temporal expression of S100B in cells of oligodendrocyte lineage. Glia. 51(2):81\u201397","journal-title":"Glia."},{"issue":"2","key":"1786_CR48","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/jnc.14574","volume":"148","author":"F Michetti","year":"2019","unstructured":"Michetti F, D'Ambrosi N, Toesca A, Puglisi MA, Serrano A, Marchese E, Corvino V, Geloso MC (2019) The S100B story: from biomarker to active factor in neural injury. J Neurochem 148(2):168\u2013187","journal-title":"J Neurochem"},{"issue":"4","key":"1786_CR49","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1096\/fj.09-139634","volume":"24","author":"F Fang","year":"2010","unstructured":"Fang F, Lue LF, Yan S, Xu H, Luddy JS, Chen D, Walker DG, Stern DM et al (2010) RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning\/memory in a mouse model of Alzheimer's disease. FASEB J 24(4):1043\u20131055","journal-title":"FASEB J"},{"key":"1786_CR50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2019.07.045","volume":"517","author":"L Huang","year":"2019","unstructured":"Huang L, Zhang L, Liu Z, Zhao S, Xu D, Li L, Peng Q, Ai Y (2019) Pentamidine protects mice from cecal ligation and puncture-induced brain damage via inhibiting S100B\/RAGE\/NF-kappaB. Biochem Biophys Res Commun 517:221\u2013226","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1786_CR51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1189\/jlb.0306198","volume":"81","author":"R Bianchi","year":"2007","unstructured":"Bianchi R, Adami C, Giambanco I, Donato R (2007) S100B binding to RAGE in microglia stimulates COX-2 expression. J Leukoc Biol 81(1):108\u2013118","journal-title":"J Leukoc Biol"},{"issue":"2","key":"1786_CR52","doi-asserted-by":"crossref","first-page":"e89548","DOI":"10.1371\/journal.pone.0089548","volume":"9","author":"M Chen","year":"2014","unstructured":"Chen M, Glenn JV, Dasari S, McVicar C, Ward M, Colhoun L, Quinn M, Bierhaus A et al (2014) RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization. PLoS One 9(2):e89548","journal-title":"PLoS One"},{"issue":"1","key":"1786_CR53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0022-510X(92)90194-P","volume":"108","author":"HG Jenkins","year":"1992","unstructured":"Jenkins HG, Ikeda H (1992) Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve. J Neurol Sci 108(1):99\u2013104","journal-title":"J Neurol Sci"},{"issue":"1","key":"1786_CR54","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41598-018-36878-z","volume":"9","author":"DVS Costa","year":"2019","unstructured":"Costa DVS, Bon-Frauches AC, Silva A, Lima-Junior RCP, Martins CS, Leitao RFC et al (2019) 5-Fluorouracil induces enteric neuron death and glial activation during intestinal mucositis via a S100B-RAGE-NFkappaB-dependent pathway. Sci Rep 9(1):665","journal-title":"Sci Rep"},{"issue":"4","key":"1786_CR55","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0197-4580(03)00126-X","volume":"25","author":"SH Kim","year":"2004","unstructured":"Kim SH, Smith CJ, Van Eldik LJ (2004) Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiol Aging 25(4):431\u2013439","journal-title":"Neurobiol Aging"},{"key":"1786_CR56","doi-asserted-by":"crossref","first-page":"9348651","DOI":"10.1155\/2016\/9348651","volume":"2016","author":"S Piras","year":"2016","unstructured":"Piras S, Furfaro AL, Domenicotti C, Traverso N, Marinari UM, Pronzato MA et al (2016) RAGE expression and ROS generation in neurons: differentiation versus damage. Oxidative Med Cell Longev 2016:9348651","journal-title":"Oxidative Med Cell Longev"},{"issue":"1\u20133","key":"1786_CR57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12026-008-8025-1","volume":"42","author":"LA Solt","year":"2008","unstructured":"Solt LA, May MJ (2008) The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res 42(1\u20133):3\u201318","journal-title":"Immunol Res"},{"issue":"11","key":"1786_CR58","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","volume":"10","author":"UK Hanisch","year":"2007","unstructured":"Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10(11):1387\u20131394","journal-title":"Nat Neurosci"},{"issue":"2","key":"1786_CR59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/1098-1136(200102)33:2<131::AID-GLIA1012>3.0.CO;2-D","volume":"33","author":"C Adami","year":"2001","unstructured":"Adami C, Sorci G, Blasi E, Agneletti AL, Bistoni F, Donato R (2001) S100B expression in and effects on microglia. Glia. 33(2):131\u2013142","journal-title":"Glia."},{"issue":"2","key":"1786_CR60","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","volume":"53","author":"Y Tang","year":"2016","unstructured":"Tang Y, Le W (2016) Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 53(2):1181\u20131194","journal-title":"Mol Neurobiol"},{"issue":"4","key":"1786_CR61","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1\/M2 polarization and metabolic states. Br J Pharmacol 173(4):649\u2013665","journal-title":"Br J Pharmacol"},{"issue":"11\u201312","key":"1786_CR62","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00011-018-1187-y","volume":"67","author":"S Zhou","year":"2018","unstructured":"Zhou S, Zhu W, Zhang Y, Pan S, Bao J (2018) S100B promotes microglia M1 polarization and migration to aggravate cerebral ischemia. Inflamm Res 67(11\u201312):937\u2013949","journal-title":"Inflamm Res"},{"issue":"105","key":"1786_CR63","first-page":"cm1","volume":"3","author":"A Weber","year":"2010","unstructured":"Weber A, Wasiliew P, Kracht M (2010) Interleukin-1 (IL-1) pathway. Sci Signal 3(105):cm1","journal-title":"Sci Signal"},{"issue":"9","key":"1786_CR64","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1089\/089771501750451857","volume":"18","author":"O Nesic","year":"2001","unstructured":"Nesic O, Xu GY, McAdoo D, High KW, Hulsebosch C, Perez-Pol R (2001) IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury. J Neurotrauma 18(9):947\u2013956","journal-title":"J Neurotrauma"},{"issue":"3","key":"1786_CR65","first-page":"792","volume":"140","author":"Z Fan","year":"2017","unstructured":"Fan Z, Brooks DJ, Okello A, Edison P (2017) An early and late peak in microglial activation in Alzheimer\u2019s disease trajectory. Brain. 140(3):792\u2013803","journal-title":"Brain."},{"key":"1786_CR66","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fnagi.2017.00227","volume":"9","author":"EH H","year":"2017","unstructured":"H EH, Noristani HN, Perrin FE (2017) Microglia responses in acute and chronic neurological diseases: what microglia-specific transcriptomic studies taught (and did not teach) us. Front Aging Neurosci 9:227","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"1786_CR67","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.legalmed.2011.12.007","volume":"14","author":"DR Li","year":"2012","unstructured":"Li DR, Zhang F, Wang Y, Tan XH, Qiao DF, Wang HJ, Michiue T, Maeda H (2012) Quantitative analysis of GFAP- and S100 protein-immunopositive astrocytes to investigate the severity of traumatic brain injury. Legal Med 14(2):84\u201392","journal-title":"Legal Med"},{"issue":"3","key":"1786_CR68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF00218111","volume":"231","author":"H Kondo","year":"1983","unstructured":"Kondo H, Iwanaga T, Nakajima T (1983) An immunocytochemical study on the localization of S-100 protein in the retina of rats. Cell Tissue Res 231(3):527\u2013532","journal-title":"Cell Tissue Res"},{"issue":"3","key":"1786_CR69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0167-4889(96)00095-X","volume":"1313","author":"J Hu","year":"1996","unstructured":"Hu J, Van Eldik LJ (1996) S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway. Biochim Biophys Acta 1313(3):239\u2013245","journal-title":"Biochim Biophys Acta"},{"issue":"13","key":"1786_CR70","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.1074\/jbc.M805897200","volume":"284","author":"F Brozzi","year":"2009","unstructured":"Brozzi F, Arcuri C, Giambanco I, Donato R (2009) S100B protein regulates astrocyte shape and migration via interaction with Src kinase: implications for astrocyte development, activation, and tumor growth. J Biol Chem 284(13):8797\u20138811","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"1786_CR71","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jneuroim.2011.11.011","volume":"243","author":"C Reali","year":"2012","unstructured":"Reali C, Pillai R, Saba F, Cabras S, Michetti F, Sogos V (2012) S100B modulates growth factors and costimulatory molecules expression in cultured human astrocytes. J Neuroimmunol 243(1\u20132):95\u201399","journal-title":"J Neuroimmunol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01786-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-01786-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01786-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T18:56:44Z","timestamp":1695409004000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-01786-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,9]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1786"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-01786-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,9]]},"assertion":[{"value":"1 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was carried out in accordance with the recommendations of ARVO Statement for the Use of Animals in Ophthalmic and Vision Research. The protocol was approved by the animal care committee of North Rhine-Westphalia in Germany (84-02.04.2013.A442).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict Interest"}}]}}